Hypoxia and its downstream targets in DMBA induced mammary carcinoma: Protective role of Semecarpus anacardium nut extract

Chemico-Biological Interactions

Volumn 167, Issue 1, 2007, Pages 31-40

  Mathivadhani, Panneerselvam ^a   Shanthi, Palanivelu ^a   Sachdanandam, Panchanatham ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Downstream targets; HIF; Mammary carcinoma; Semecarpus anacardium

Indexed keywords

CARBONATE DEHYDRATASE IX; DIMETHYLBENZ[A]ANTHRACENE; GLUCOSE TRANSPORTER 1; GLYCOLYTIC ENZYME; HYPOXIA INDUCIBLE FACTOR 1; INDUCIBLE NITRIC OXIDE SYNTHASE; SEMECARPUS ANACARDIUM EXTRACT; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER GROWTH; CANCER MODEL; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ENDOTHELIUM CELL; ENZYME ACTIVITY; FEMALE; GENE CONTROL; HYPOXIA; NONHUMAN; PROTEIN EXPRESSION; SEMECARPUS; SEMECARPUS ANACARDIUM; TUMOR VASCULARIZATION;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANOXIA; ANTINEOPLASTIC AGENTS; CARBONIC ANHYDRASES; CARCINOGENS; CARCINOMA; ENDOTHELIAL CELLS; FEMALE; GLUCOSE TRANSPORTER TYPE 1; GLYCOLYSIS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MAMMARY NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; NITRIC OXIDE SYNTHASE TYPE II; NUTS; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SEMECARPUS; TUMOR BURDEN; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

RATTUS; SEMECARPUS ANACARDIUM;

EID: 33947172400     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2007.01.003     Document Type: Article

References (69)

1. Graeber T.G., Osmanian C., Jacks T., Housman D.E., Koch C.J., Lowe S.W., and Giaccia A.J. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature (London) 379 (1996) 88-91
2. Wenger R.H., and Gassmann M. Environmental Stress and Gene Regulation (1999), BIOS Scientific, Washington, DC pp. xvi and 181.
3. Forsythe J.A., Jiang B.H., Iyer N.V., Agani F., Leung S.W., Coos R.D., and Semenza G.L. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 16 (1996) 4604-4613
4. Pastorekova S., Parkkila S., Parkkila A.K., Opavsky R., Zelnik V., Saarnio J., and Pastorek J. Carbonic anhydrase IX, MN/CA IX, analysis of stomach complimentary DNA sequence and expression in human and rat alimantary tracts. Gastroenterology 112 (1997) 398-408
5. Maeda H., and Akaike T. Nitric oxide and oxygen radicals in infection, inflammation, and cancer. Biochemistry (Mosc.) 63 (1998) 854-865
6. Newsholme H.A., and Board M. Application of metabolic-control logic to fuel utilization and its significance in tumor cells. Adv. Enzyme Regul. 31 (1991) 225-246
7. Premalatha B., and Sachdanandam P. Semecarpus anacardium Linn. nut extract administration induces the in vivo antioxidant defense system in aflatoxin B1 mediated hepatocellular carcinoma. J. Ethnopharmacol. 66 (1999) 131-139
8. Indap M.A., Ambaye R.Y., and Gokhale S.V. Antitumor and pharmacological effects of the oil from Semecarpus anacardium Linn. Ind. J. Physiol. Pharmacol. 27 (1983) 83-91
9. Premalatha B. Semecarpus anacardium Linn. nuts- A boon in alternative medicine. Indian J. Exp. Biol. 38 (2000) 1177-1182
10. B. Premalatha, V. Sujatha, P. Sachdanandam, Modulating effect of Semecarpus anacardium Linn. nut extract on glucose metabolizing enzymes in aflatoxin B1-induced experimental hepatocellular carcinoma, Pharmacol. Res. 36, 187-192.
11. Sujatha V., and Sachdanandam P. Effect of Semecarpus anacardium Linn nut extract on experimental mammary carcinoma in Sprague-Dawley rats with reference to tumor marker enzymes. Pharm. Pharmacol. Commun. 6 1997 (2000) 375-379
12. Ramprasath V.R., Shanthi P., and Sachdanandam P. Evaluation of antioxidant effect of Semecarpus anacardium Linn. nut extract on the components of immune system in adjuvant arthritis. Vasc. Pharmacol. 42 (2005) 179-186
13. Formulary of Siddha Medicine, IInd edn. Published by the Indian Medical Practitioners Co-operative Pharmacy and Stores Ltd., 1972. India.
14. Welsch C.W. Factors affecting the growth of carcinogen induced rat mammary carcinomas. A review and tribute to Charles Brendon Huggins. Cancer Res. 45 (1985) 3415-3443
15. Burrows F.J., Watanabe Y., and Thorpe P.E. A murine model for antibody-directed targeting of vascular endothelial cells in solid tumors. Cancer Res. 52 (1992) 5954-5962
16. Benjamin L.E., Golijanin D., Itin A., Pode D., and Keshet E. Selective abalation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J. Clin. Invest. 103 (1999) 159-165
17. Banstrup N., Kirk J.E., and Bruni C. Hexokinase and phosphoglucoisomerase activities of aortic and pulmonary artery tissue in individual of various ages. J. Gerentol. 12 (1957) 166-170
18. King J. The Transferase Alanine and Aspartate Transaminase. In Practical Clinical Enzymology (1965), Van Nostrand Co, London pp. 121-138
19. Sauter E.R., Nesbit M., Watson J.C., Klein-Szanto A., Litwin S., and Herlyn M. Vascular endothelial growth factor is a marker of tumor invasion and metastasis in squamous cell carcinomas of the head and neck. Clin. Cancer Res. 5 (1999) 775-782
20. Weidner N., Semple J.P., Welch W.R., and Folkman J. Tumor angiogenesis and metastasis, correlation in invasive breast carcinoma. N. Engl. J. Med. 324 (1991) 1-8
21. Gasparini G., and Harris A.L. Clinical importance of the determination of tumor angiogenesis in breast carcinoma, much more than a new prognostic tool. J. Clin. Oncol. 13 (1995) 765-782
22. Semenza G.L. HIF-1 and tumor progression, pathophysiology and therapeutics. Trends Mol. Med. 8 Suppl. 4 (2002) S62-S67
23. Eugene D., Brain J., and James T. Coordinate regulation of glycolysis by hypoxia in mammalian cells. J. Cell Physiol. 118 (1984) 287-290
24. Golshani-Hebroni S.G., and Bessman S.P. Hexokinase binding to mitochondria, A basis for proliferative energy metabolism. J. Bioenerg. Biomembr. 29 (1997) 331-338
25. Hennipman A., van Oirschot B.A., Smits J., Rijksen G., and Staal G.E. Heterogeneity of glycolytic enzyme activity and isozyme composition of pyruvate kinase in breast cancer. Tumor Biol. 9 (1988) 178-189
26. Gudnason V., Ingvarsson S., Jonasdottir A., Andresdottir V., and Egilsson V. Isoenzyme pattern and subcellular localization of hexokinases in human breast cancer and nonpathological breast tissue. Int. J. Cancer 34 (1984) 63-66
27. Suolinna M., Buchsbaum R.N., and Racker E. The effect of flavonoid and aerobic glycolysis and growth of tumor cells. Cancer Res. 35 (1975) 1865-1872
28. Havsteen B. Flavonoids, a class of natural products of high pharmacology potency. Biochem. Pharm. 32 (1983) 1141-1148
29. Guillemin K., and Krasnow M.A. The hypoxic response, minireview huffing and HIFing. Cell 89 (1997) 9-12
30. Dales J.P., Garcia S., Carpentier S.M., Meyer L.A., Haddad O., Lavaut M.N., Allasia C., Bonnier P., and Charpin C. Overexpression of hypoxia-inducible factor HIF-1alpha predicts early relapse in breast cancer, retrospective study in a series of 745 patients. Int. J. Cancer 116 (2005) 734-739
31. Zhong H., De Marzo A.M., Laughner E., Lim M., Hilton D.A., Zagzag D., Buechler P., Isaacs W.B., Semenza G., and Simons J.W. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res. 59 (1999) 5830-5835
32. Bos R., Zhong H., Hanrahan C.H., Mommers E.C.M., Semenza G.L., Pinedo Abeloff M.D., Simons J.W., van Diest P.J., and van der Wall E. Levels of hypoxia-inducible factor-1α during breast carcinogenesis. J. Natl. Cancer Inst. 93 (2001) 309-314
33. 2-regulated prolyl hydroxylation. Science 292 (2001) 464-468
34. Tanimoto K., Makino Y., Pereira T., and Poellinger L. Mechanism of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor protein. EMBO J. 19 (2000) 4298-4309
35. Sutter C.H., Laughner E., and Semenza G.L. HIF-1α protein expressionis controlled by oxygen-ubiquitination that is disrupted by deletions and missense mutations. Proc. Natl. Acad. Sci. 97 (2000) 4748-4753
36. Chun Y.S., Lee K.H., Choi E., Bae S.Y., Yeo E.J., Huang L.E., Kim M.S., and Park J.W. Phorbol ester stimulates the nonhypoxic induction of a novel hypoxia-inducible factor 1alpha isoform, implications for tumor promotion. Cancer Res. 63 (2003) 8700-8707
37. Ellis L.M., Staley C.A., Liu W., Fleming R.Y., Parikh N.U., Bucana C.D., and Gallick G.E. Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for csrc. J. Biol. Chem. 273 (1998) 1052-1057
38. Namiki A., Brogi E., Kearney M., Kim E.A., Wu T., Couffinhal T., Varticovski L., and Isner J.M. Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells. J. Biol. Chem. 270 (1995) 31189-31195
39. Niu G., Wright K.L., Huang M., Song L., Haura E., Turkson J., Zhang S., Wang T., Sinibaldi D., Coppola D., Heller R., Ellis L.M., Karras J., Bromberg J., Pardoll D., Jove R., and Yu H. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 21 (2002) 2000-2008
40. Wei D., Le X., Zheng L., Wang L., Frey J.A., Gao A.C., Peng Z., Huang S., Xiong H.Q., Abbruzzese J.L., and Xie K. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 22 (2003) 319-329
41. Shemirani B., and Crowe D.L. Hypoxic induction of HIF-1alpha and VEGF expression in head and neck squamous cell carcinoma lines is mediated by stress activated protein kinases. Oral Oncol. 38 (2002) 251-257
42. Zundel W., Schindler C., Haas-Kogan D., Koong A., Kaper F., Chen E., Gottschalk A.R., Ryan H.E., Johnson R.S., Jefferson A.B., Stokoe D., and Giaccia A.J. Lossof PTEN facilitates HIF-1 mediated gene expression. Genes Dev. 14 (2000) 391-396
43. Fang J., Xia C., Cao Z., Zheng J.Z., Reed E., and Jiang B.-H. Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. FASEB J. 19 (2005) 342-353
44. Brown L.F., Detmar M., Claffey K., Nagy J.A., Feng D., Dvorak A.M., and Dvorak H.F. Vascular permeability factor/vascular endothelial growth factor, a multifunctional angiogenic cytokine. EXS 79 (1997) 233-269
45. Detmar M., Velasco P., Richard L., Claffey K.P., Streit M., Riccardi L., Skobe M., and Brown L.F. Expression of vascular endothelial growth factor induces an invasive phenotype in human squamous cell carcinomas. Am. J. Pathol. 156 (2000) 159-167
46. Takahashi Y., Kitadai Y., Bucana C.D., Cleary K.R., and Ellis L.M. Expression of vascular endothelial growth factor and its receptor KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res. 55 (1995) 3964-3968
47. Guidi J.A., Schnitt S.J., Fishcer L., Tognazzi K., Harris J.R., Dvorak H.F., and Brown L.F. Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in patients with ductal carcinoma in situ of the breast. Cancer 15 (1997) 1945-1953
48. Detmar M., Brown L.F., Berse B., Jackman R.W., Elicker B.M., Dvorak H.F., and Claffey K.P. Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptors in human skin. J. Invest. Dermatol. 108 (1997) 263-268
49. Gerber H.P., Condorelli F., Park J., and Ferrara N. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J. Biol. Chem. 272 (1997) 23659-23667
50. Seagroves T.N., Hadsell D., McManaman J., Palmer C., Liao D., McNulty W., Welm B., Wagner K., Neville M., and Johnson R.S. HIF1α is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland. Development 130 (2003) 1713-1724
51. Fotsis T., Pepper M.S., Aktas E., Breit S., Rasku S., Adlercreutz H., Wahala K., Montesano R., and Schweigerer L. Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis. Cancer Res. 57 (1997) 2916-2921
52. Grover-Mckay M., Walsh S.A., Seftor E.A., Thomas P.A., and Jc Hendrix M. Role for glucose transporter 1 protein in human breast cancer. Pathol. Oncol. Res. 4 (1998) 115-120
53. Ito H., Duxbury M., Zinner M.J., Ashley S.W., and Whang E.E. Glucose transporter-1 gene expression is associated with pancreatic cancer invasiveness and MMP-2 activity. Surgery 136 (2004) 548-556
54. Younes M., Lechago L.V., Somoano J.R., Mosharaf M., and Lechago J. Wide expression of the human erythrocyte glucose transporter Glut1 in human cancer. Cancer Res. 56 (1996) 1164-1167
55. Merrall N.W., Plevin R., and Gould G.W. Growth factors, mitogens, oncogenes, and the regulation of glucose transport. Cell. Signal. 5 (1993) 667-675
56. Ismail-Beigi F., and Vanderburg G. Effect of GLUT1 glucose transporter overexpression on the stimulation of glucose transport in response to inhibition of oxidative phosphorylation. Arch. Biochem. Biophys. 331 (1996) 201-207
57. Datta K., Li J., Bhattacharya R., Gasparian L., Wang E., and Mukhopadhyay D. Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer. Cancer Res. 64 (2004) 456-462
58. Chen C., Pore N., Behrooz A., Ismail-Beigi F., and Maity A. Regulation of glut1 mRNA by hypoxia-inducible factor-1, Interaction between H-ras and hypoxia. J. Biol. Chem. 276 (2001) 9519-9525
59. Palmer L.A., Semenza G.L., Stoler M.H., and Johns R.A. Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. Am. J. Physiol. 274 (1998) L212-L219
60. Natarajan R., Jones D.G., Fisher B.J., Wallace T.J., Ghosh S., and Fowler A.A. Hypoxia inducible factor-1, regulation by nitric oxide in posthypoxic microvascular endothelium. Biochem. Cell Biol. 83 (2005) 597-607
61. Quintero M., Brennan P.A., Thomas G.J., and Moncada S. Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1 in cancer role of free radical formation. Cancer Res. 66 (2006) 770-774
62. 2 sensing. J. Biol. Chem. 275 (2000) 25130-25138
63. Pergola C., Rossi A., Dugo P., Cuzzocrea S., and Sautebin L. Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract. Nitric Oxide 15 (2006) 30-39
64. Watson P.H., Chia S.K., Wykoff C.C., Han C., Leek R.D., Sly W.S., Gatter K.C., Ratcliffe P., and Harris A.L. Carbonic anhydrase XII is a marker of good prognosis in invasive breast carcinoma. Br. J. Cancer 88 (2003) 1065-1070
65. Nemoto S., Takeda K., Yu Z.X., Ferrans V.J., and Finkel T. Role for mitochondrial oxidants as regulators of cellular metabolism. Mol. Cell. Biol. 20 (2000) 7311-7318
66. Fischer B., Muller B., Fischer K.G., Baur N., and Kreutz W. Acidic pH inhibits non-MHC-restricted killer cell functions. Clin. Immunol. 96 (2000) 252-263
67. Ten V.S., and Pinsky D.J. Endothelial response to hypoxia, physiologic adaptation and pathologic dysfunction. Curr. Opin. Crit. Care 8 (2002) 242-250
68. Shi Q., Abbruzzese J.L., Huang S., Fidler I.J., Xiong Q., and Xie K. Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic. Clin. Cancer Res. 5 (1999) 3711-3721
69. Tang N., Wang L., Esko J., Giordano F.J., Huang Y., Gerber H., Ferrara N., and Johnson R.S. Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 6 (2004) 485-495