메뉴 건너뛰기




Volumn 42, Issue , 2014, Pages 10-21

Obesity and neuroinflammation: A pathway to cognitive impairment

Author keywords

Cognition; High fat diet; Hypothalamus; Inflammation; Obesity

Indexed keywords

CYTOKINE; FAT; FATTY ACID;

EID: 84908651577     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2014.04.001     Document Type: Article
Times cited : (550)

References (203)
  • 4
    • 33745447477 scopus 로고    scopus 로고
    • Executive function and the frontal lobes: a meta-analytic review
    • Alvarez J.A., Emory E. Executive function and the frontal lobes: a meta-analytic review. Neuropsychol. Rev. 2006, 16(1):17-42.
    • (2006) Neuropsychol. Rev. , vol.16 , Issue.1 , pp. 17-42
    • Alvarez, J.A.1    Emory, E.2
  • 5
    • 18744394346 scopus 로고    scopus 로고
    • The 9 year cognitive decline before dementia of the Alzheimer type: a prospective population-based study
    • Amieva H., Jacqmin-Gadda H., Orgogozo J.M., Le Carret N., Helmer C., Letenneur L., et al. The 9 year cognitive decline before dementia of the Alzheimer type: a prospective population-based study. Brain 2005, 128(Pt 5):1093-1101.
    • (2005) Brain , vol.128 , pp. 1093-1101
    • Amieva, H.1    Jacqmin-Gadda, H.2    Orgogozo, J.M.3    Le Carret, N.4    Helmer, C.5    Letenneur, L.6
  • 6
    • 79954996833 scopus 로고    scopus 로고
    • Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies
    • Anstey K.J., Cherbuin N., Budge M., Young J. Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies. Obes. Rev. 2011, 12(5):e426-e437.
    • (2011) Obes. Rev. , vol.12 , Issue.5 , pp. e426-e437
    • Anstey, K.J.1    Cherbuin, N.2    Budge, M.3    Young, J.4
  • 7
  • 9
    • 80051572053 scopus 로고    scopus 로고
    • Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes
    • Barrientos R.M., Frank M.G., Crysdale N.Y., Chapman T.R., Ahrendsen J.T., Day H.E., et al. Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes. J. Neurosci. 2011, 31(32):11578-11586.
    • (2011) J. Neurosci. , vol.31 , Issue.32 , pp. 11578-11586
    • Barrientos, R.M.1    Frank, M.G.2    Crysdale, N.Y.3    Chapman, T.R.4    Ahrendsen, J.T.5    Day, H.E.6
  • 10
    • 42249107660 scopus 로고    scopus 로고
    • Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis
    • Beydoun M.A., Beydoun H.A., Wang Y. Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis. Obes. Rev. 2008, 9(3):204-218.
    • (2008) Obes. Rev. , vol.9 , Issue.3 , pp. 204-218
    • Beydoun, M.A.1    Beydoun, H.A.2    Wang, Y.3
  • 11
    • 77953521826 scopus 로고    scopus 로고
    • Enduring consequences of maternal obesity for brain inflammation and behavior of offspring
    • Bilbo S.D., Tsang V. Enduring consequences of maternal obesity for brain inflammation and behavior of offspring. FASEB J. 2010, 24(6):2104-2115.
    • (2010) FASEB J. , vol.24 , Issue.6 , pp. 2104-2115
    • Bilbo, S.D.1    Tsang, V.2
  • 12
    • 77951948444 scopus 로고    scopus 로고
    • Childhood obesity and adult morbidities
    • Biro F.M., Wien M. Childhood obesity and adult morbidities. Am. J. Clin. Nutr. 2010, 91(5):1499S-1505S.
    • (2010) Am. J. Clin. Nutr. , vol.91 , Issue.5 , pp. 1499S-1505S
    • Biro, F.M.1    Wien, M.2
  • 13
    • 34447532118 scopus 로고    scopus 로고
    • The onset of fever: new insights into its mechanism
    • Blatteis C.M. The onset of fever: new insights into its mechanism. Prog. Brain Res. 2007, 162:3-14.
    • (2007) Prog. Brain Res. , vol.162 , pp. 3-14
    • Blatteis, C.M.1
  • 14
    • 0029417080 scopus 로고
    • Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients
    • Blum-Degen D., Muller T., Kuhn W., Gerlach M., Przuntek H., Riederer P. Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients. Neurosci. Lett. 1995, 202(1-2):17-20.
    • (1995) Neurosci. Lett. , vol.202 , Issue.1-2 , pp. 17-20
    • Blum-Degen, D.1    Muller, T.2    Kuhn, W.3    Gerlach, M.4    Przuntek, H.5    Riederer, P.6
  • 16
    • 84871027393 scopus 로고    scopus 로고
    • Cannabinoid receptor 2 signaling in peripheral immune cells modulates disease onset and severity in mouse models of Huntington's disease
    • Bouchard J., Truong J., Bouchard K., Dunkelberger D., Desrayaud S., Moussaoui S., et al. Cannabinoid receptor 2 signaling in peripheral immune cells modulates disease onset and severity in mouse models of Huntington's disease. J. Neurosci. 2012, 32(50):18259-18268.
    • (2012) J. Neurosci. , vol.32 , Issue.50 , pp. 18259-18268
    • Bouchard, J.1    Truong, J.2    Bouchard, K.3    Dunkelberger, D.4    Desrayaud, S.5    Moussaoui, S.6
  • 17
    • 84862916719 scopus 로고    scopus 로고
    • Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic-pituitary-adrenal axis
    • Braun T.P., Zhu X., Szumowski M., Scott G.D., Grossberg A.J., Levasseur P.R., et al. Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic-pituitary-adrenal axis. J. Exp. Med. 2011, 208(12):2449-2463.
    • (2011) J. Exp. Med. , vol.208 , Issue.12 , pp. 2449-2463
    • Braun, T.P.1    Zhu, X.2    Szumowski, M.3    Scott, G.D.4    Grossberg, A.J.5    Levasseur, P.R.6
  • 18
    • 84873713360 scopus 로고    scopus 로고
    • Late-life obesity is associated with smaller global and regional gray matter volumes: a voxel-based morphometric study
    • Brooks S.J., Benedict C., Burgos J., Kempton M.J., Kullberg J., Nordenskjold R., et al. Late-life obesity is associated with smaller global and regional gray matter volumes: a voxel-based morphometric study. Int. J. Obes. 2013, 37(2):230-236.
    • (2013) Int. J. Obes. , vol.37 , Issue.2 , pp. 230-236
    • Brooks, S.J.1    Benedict, C.2    Burgos, J.3    Kempton, M.J.4    Kullberg, J.5    Nordenskjold, R.6
  • 19
    • 67649421600 scopus 로고    scopus 로고
    • Modifiers of cognitive function and brain structure in middle-aged and elderly individuals with type 2 diabetes mellitus
    • Bruehl H., Wolf O.T., Sweat V., Tirsi A., Richardson S., Convit A. Modifiers of cognitive function and brain structure in middle-aged and elderly individuals with type 2 diabetes mellitus. Brain Res. 2009, 1280:186-194.
    • (2009) Brain Res. , vol.1280 , pp. 186-194
    • Bruehl, H.1    Wolf, O.T.2    Sweat, V.3    Tirsi, A.4    Richardson, S.5    Convit, A.6
  • 20
    • 84863431784 scopus 로고    scopus 로고
    • Inflammatory cause of metabolic syndrome via brain stress and NF-kappaB
    • Cai D., Liu T. Inflammatory cause of metabolic syndrome via brain stress and NF-kappaB. Aging 2012, 4(2):98-115.
    • (2012) Aging , vol.4 , Issue.2 , pp. 98-115
    • Cai, D.1    Liu, T.2
  • 21
    • 84882761023 scopus 로고    scopus 로고
    • Minocycline alleviates beta-amyloid protein and tau pathology via restraining neuroinflammation induced by diabetic metabolic disorder
    • Cai Z., Yan Y., Wang Y. Minocycline alleviates beta-amyloid protein and tau pathology via restraining neuroinflammation induced by diabetic metabolic disorder. Clin. Interv. Aging 2013, 8:1089-1095.
    • (2013) Clin. Interv. Aging , vol.8 , pp. 1089-1095
    • Cai, Z.1    Yan, Y.2    Wang, Y.3
  • 22
    • 84879065487 scopus 로고    scopus 로고
    • Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing
    • Cakir I., Cyr N.E., Perello M., Litvinov B.P., Romero A., Stuart R.C., et al. Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing. J. Biol. Chem. 2013, 288(24):17675-17688.
    • (2013) J. Biol. Chem. , vol.288 , Issue.24 , pp. 17675-17688
    • Cakir, I.1    Cyr, N.E.2    Perello, M.3    Litvinov, B.P.4    Romero, A.5    Stuart, R.C.6
  • 23
    • 84887076229 scopus 로고    scopus 로고
    • Diet-induced obesity induces endoplasmic reticulum stress and insulin resistance in the amygdala of rats
    • Castro G., C.Areias M.F., Weissmann L., Quaresma P.G., Katashima C.K., Saad M.J., et al. Diet-induced obesity induces endoplasmic reticulum stress and insulin resistance in the amygdala of rats. FEBS Open Bio 2013, 3:443-449.
    • (2013) FEBS Open Bio , vol.3 , pp. 443-449
    • Castro, G.1    C.Areias, M.F.2    Weissmann, L.3    Quaresma, P.G.4    Katashima, C.K.5    Saad, M.J.6
  • 24
    • 0030690043 scopus 로고    scopus 로고
    • Factors associated with cognitive impairment among older Italian inpatients. Gruppo Italiano di Farmacovigilanza nell'Anziano (G.I.F.A.)
    • Cattin L., Bordin P., Fonda M., Adamo C., Barbone F., Bovenzi M., et al. Factors associated with cognitive impairment among older Italian inpatients. Gruppo Italiano di Farmacovigilanza nell'Anziano (G.I.F.A.). J. Am. Geriatr. Soc. 1997, 45(11):1324-1330.
    • (1997) J. Am. Geriatr. Soc. , vol.45 , Issue.11 , pp. 1324-1330
    • Cattin, L.1    Bordin, P.2    Fonda, M.3    Adamo, C.4    Barbone, F.5    Bovenzi, M.6
  • 25
    • 79151485914 scopus 로고    scopus 로고
    • Obesity-mediated inflammation may damage the brain circuit that regulates food intake
    • Cazettes F., Cohen J.I., Yau P.L., Talbot H., Convit A. Obesity-mediated inflammation may damage the brain circuit that regulates food intake. Brain Res. 2011, 1373:101-109.
    • (2011) Brain Res. , vol.1373 , pp. 101-109
    • Cazettes, F.1    Cohen, J.I.2    Yau, P.L.3    Talbot, H.4    Convit, A.5
  • 27
    • 8344273480 scopus 로고    scopus 로고
    • Nuclear factor kappa B activation by NADPH oxidases
    • Clark R.A., Valente A.J. Nuclear factor kappa B activation by NADPH oxidases. Mech. Ageing Dev. 2004, 125(10-11):799-810.
    • (2004) Mech. Ageing Dev. , vol.125 , Issue.10-11 , pp. 799-810
    • Clark, R.A.1    Valente, A.J.2
  • 28
    • 33749861878 scopus 로고    scopus 로고
    • Relation between body mass index and cognitive function in healthy middle-aged men and women
    • Cournot M., Marquie J.C., Ansiau D., Martinaud C., Fonds H., Ferrieres J., et al. Relation between body mass index and cognitive function in healthy middle-aged men and women. Neurology 2006, 67(7):1208-1214.
    • (2006) Neurology , vol.67 , Issue.7 , pp. 1208-1214
    • Cournot, M.1    Marquie, J.C.2    Ansiau, D.3    Martinaud, C.4    Fonds, H.5    Ferrieres, J.6
  • 29
    • 35648957138 scopus 로고    scopus 로고
    • Is there any relationship between obesity and mental flexibility in children?
    • Cserjesi R., Molnar D., Luminet O., Lenard L. Is there any relationship between obesity and mental flexibility in children?. Appetite 2007, 49(3):675-678.
    • (2007) Appetite , vol.49 , Issue.3 , pp. 675-678
    • Cserjesi, R.1    Molnar, D.2    Luminet, O.3    Lenard, L.4
  • 30
    • 29244462498 scopus 로고    scopus 로고
    • Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway
    • Cullinan S.B., Diehl J.A. Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway. Int. J. Biochem. Cell Biol. 2006, 38(3):317-332.
    • (2006) Int. J. Biochem. Cell Biol. , vol.38 , Issue.3 , pp. 317-332
    • Cullinan, S.B.1    Diehl, J.A.2
  • 31
    • 57149142096 scopus 로고    scopus 로고
    • Overweight and obesity in old age are not associated with greater dementia risk
    • Dahl A.K., Lopponen M., Isoaho R., Berg S., Kivela S.L. Overweight and obesity in old age are not associated with greater dementia risk. J. Am. Geriatr. Soc. 2008, 56(12):2261-2266.
    • (2008) J. Am. Geriatr. Soc. , vol.56 , Issue.12 , pp. 2261-2266
    • Dahl, A.K.1    Lopponen, M.2    Isoaho, R.3    Berg, S.4    Kivela, S.L.5
  • 32
    • 24944438230 scopus 로고    scopus 로고
    • Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
    • De Souza C.T., Araujo E.P., Bordin S., Ashimine R., Zollner R.L., Boschero A.C., et al. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 2005, 146(10):4192-4199.
    • (2005) Endocrinology , vol.146 , Issue.10 , pp. 4192-4199
    • De Souza, C.T.1    Araujo, E.P.2    Bordin, S.3    Ashimine, R.4    Zollner, R.L.5    Boschero, A.C.6
  • 33
    • 80051508807 scopus 로고    scopus 로고
    • Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline
    • Debette S., Seshadri S., Beiser A., Au R., Himali J.J., Palumbo C., et al. Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline. Neurology 2011, 77(5):461-468.
    • (2011) Neurology , vol.77 , Issue.5 , pp. 461-468
    • Debette, S.1    Seshadri, S.2    Beiser, A.3    Au, R.4    Himali, J.J.5    Palumbo, C.6
  • 34
    • 33846892751 scopus 로고    scopus 로고
    • Psychosocial and physical impairment in overweight adolescents at high risk for eating disorders
    • Doyle A.C., le Grange D., Goldschmidt A., Wilfley D.E. Psychosocial and physical impairment in overweight adolescents at high risk for eating disorders. Obesity (Silver Spring, Md) 2007, 15(1):145-154.
    • (2007) Obesity (Silver Spring, Md) , vol.15 , Issue.1 , pp. 145-154
    • Doyle, A.C.1    le Grange, D.2    Goldschmidt, A.3    Wilfley, D.E.4
  • 35
    • 27944491254 scopus 로고    scopus 로고
    • Cortisol level predicts executive and memory function in depression, symptom level predicts psychomotor speed
    • Egeland J., Lund A., Landro N.I., Rund B.R., Sundet K., Asbjornsen A., et al. Cortisol level predicts executive and memory function in depression, symptom level predicts psychomotor speed. Acta Psychiatr. Scand. 2005, 112(6):434-441.
    • (2005) Acta Psychiatr. Scand. , vol.112 , Issue.6 , pp. 434-441
    • Egeland, J.1    Lund, A.2    Landro, N.I.3    Rund, B.R.4    Sundet, K.5    Asbjornsen, A.6
  • 37
    • 0034084815 scopus 로고    scopus 로고
    • The preclinical phase of alzheimer disease: a 22-year prospective study of the Framingham Cohort
    • Elias M.F., Beiser A., Wolf P.A., Au R., White R.F., D'Agostino R.B. The preclinical phase of alzheimer disease: a 22-year prospective study of the Framingham Cohort. Arch. Neurol. 2000, 57(6):808-813.
    • (2000) Arch. Neurol. , vol.57 , Issue.6 , pp. 808-813
    • Elias, M.F.1    Beiser, A.2    Wolf, P.A.3    Au, R.4    White, R.F.5    D'Agostino, R.B.6
  • 40
    • 18844445577 scopus 로고    scopus 로고
    • Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects
    • Enzinger C., Fazekas F., Matthews P.M., Ropele S., Schmidt H., Smith S., et al. Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects. Neurology 2005, 64(10):1704-1711.
    • (2005) Neurology , vol.64 , Issue.10 , pp. 1704-1711
    • Enzinger, C.1    Fazekas, F.2    Matthews, P.M.3    Ropele, S.4    Schmidt, H.5    Smith, S.6
  • 41
    • 77954005130 scopus 로고    scopus 로고
    • Endogenous ligands of TLR2 and TLR4: agonists or assistants?
    • Erridge C. Endogenous ligands of TLR2 and TLR4: agonists or assistants?. J. Leukoc. Biol. 2010, 87(6):989-999.
    • (2010) J. Leukoc. Biol. , vol.87 , Issue.6 , pp. 989-999
    • Erridge, C.1
  • 42
    • 84869857934 scopus 로고    scopus 로고
    • Interleukin-6, a major cytokine in the central nervous system
    • Erta M., Quintana A., Hidalgo J. Interleukin-6, a major cytokine in the central nervous system. Int. J. Biol. Sci. 2012, 8(9):1254-1266.
    • (2012) Int. J. Biol. Sci. , vol.8 , Issue.9 , pp. 1254-1266
    • Erta, M.1    Quintana, A.2    Hidalgo, J.3
  • 44
    • 84883780939 scopus 로고    scopus 로고
    • Activation of the endoplasmic reticulum stress response by the amyloid-beta 1-40 peptide in brain endothelial cells
    • Fonseca A.C., Ferreiro E., Oliveira C.R., Cardoso S.M., Pereira C.F. Activation of the endoplasmic reticulum stress response by the amyloid-beta 1-40 peptide in brain endothelial cells. Biochim. Biophys. Acta 2013, 1832(12):2191-2203.
    • (2013) Biochim. Biophys. Acta , vol.1832 , Issue.12 , pp. 2191-2203
    • Fonseca, A.C.1    Ferreiro, E.2    Oliveira, C.R.3    Cardoso, S.M.4    Pereira, C.F.5
  • 45
    • 84859608708 scopus 로고    scopus 로고
    • Modifiable factors that alter the size of the hippocampus with ageing
    • Fotuhi M., Do D., Jack C. Modifiable factors that alter the size of the hippocampus with ageing. Nat. Rev. Neurol. 2012, 8(4):189-202.
    • (2012) Nat. Rev. Neurol. , vol.8 , Issue.4 , pp. 189-202
    • Fotuhi, M.1    Do, D.2    Jack, C.3
  • 47
    • 30044434035 scopus 로고    scopus 로고
    • Intracellular signalling pathways activated by leptin
    • Fruhbeck G. Intracellular signalling pathways activated by leptin. Biochem. J. 2006, 393(Pt 1):7-20.
    • (2006) Biochem. J. , vol.393 , pp. 7-20
    • Fruhbeck, G.1
  • 48
    • 44849127652 scopus 로고    scopus 로고
    • Body mass index and magnetic resonance markers of brain integrity in adults
    • Gazdzinski S., Kornak J., Weiner M.W., Meyerhoff D.J. Body mass index and magnetic resonance markers of brain integrity in adults. Ann. Neurol. 2008, 63(5):652-657.
    • (2008) Ann. Neurol. , vol.63 , Issue.5 , pp. 652-657
    • Gazdzinski, S.1    Kornak, J.2    Weiner, M.W.3    Meyerhoff, D.J.4
  • 49
    • 77950189270 scopus 로고    scopus 로고
    • BMI and neuronal integrity in healthy, cognitively normal elderly: a proton magnetic resonance spectroscopy study
    • Gazdzinski S., Millin R., Kaiser L.G., Durazzo T.C., Mueller S.G., Weiner M.W., et al. BMI and neuronal integrity in healthy, cognitively normal elderly: a proton magnetic resonance spectroscopy study. Obesity 2010, 18(4):743-748.
    • (2010) Obesity , vol.18 , Issue.4 , pp. 743-748
    • Gazdzinski, S.1    Millin, R.2    Kaiser, L.G.3    Durazzo, T.C.4    Mueller, S.G.5    Weiner, M.W.6
  • 50
    • 0005775566 scopus 로고
    • Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells
    • Goldgaber D., Harris H.W., Hla T., Maciag T., Donnelly R.J., Jacobsen J.S., et al. Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. Proc. Nat. Acad. Sci. USA 1989, 86(19):7606-7610.
    • (1989) Proc. Nat. Acad. Sci. USA , vol.86 , Issue.19 , pp. 7606-7610
    • Goldgaber, D.1    Harris, H.W.2    Hla, T.3    Maciag, T.4    Donnelly, R.J.5    Jacobsen, J.S.6
  • 51
    • 78149245073 scopus 로고    scopus 로고
    • Role of inflammation in cognitive impairment: results of observational epidemiological studies and clinical trials
    • Gorelick P.B. Role of inflammation in cognitive impairment: results of observational epidemiological studies and clinical trials. Ann. N. Y. Acad. Sci. 2010, 1207:155-162.
    • (2010) Ann. N. Y. Acad. Sci. , vol.1207 , pp. 155-162
    • Gorelick, P.B.1
  • 52
    • 80052400687 scopus 로고    scopus 로고
    • Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association
    • Gorelick P.B., Scuteri A., Black S.E., Decarli C., Greenberg S.M., Iadecola C., et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke 2011, 42(9):2672-2713.
    • (2011) Stroke , vol.42 , Issue.9 , pp. 2672-2713
    • Gorelick, P.B.1    Scuteri, A.2    Black, S.E.3    Decarli, C.4    Greenberg, S.M.5    Iadecola, C.6
  • 53
    • 33947589960 scopus 로고    scopus 로고
    • The risk of dementia with increased body mass index
    • Gorospe E.C., Dave J.K. The risk of dementia with increased body mass index. Age Ageing 2007, 36(1):23-29.
    • (2007) Age Ageing , vol.36 , Issue.1 , pp. 23-29
    • Gorospe, E.C.1    Dave, J.K.2
  • 54
    • 84896267444 scopus 로고    scopus 로고
    • Improvements in hippocampal-dependent memory and microglial infiltration with calorie restriction and gastric bypass surgery, but not with vertical sleeve gastrectomy
    • Grayson B.E., Fitzgerald M.F., Hakala-Finch A.P., Ferris V.M., Begg D.P., Tong J., et al. Improvements in hippocampal-dependent memory and microglial infiltration with calorie restriction and gastric bypass surgery, but not with vertical sleeve gastrectomy. Int. J. Obes. (Lond.) 2014, 38(3):349-356.
    • (2014) Int. J. Obes. (Lond.) , vol.38 , Issue.3 , pp. 349-356
    • Grayson, B.E.1    Fitzgerald, M.F.2    Hakala-Finch, A.P.3    Ferris, V.M.4    Begg, D.P.5    Tong, J.6
  • 56
    • 84884185767 scopus 로고    scopus 로고
    • Cyclooxygenase-1-dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction
    • Griffin E.W., Skelly D.T., Murray C.L., Cunningham C. Cyclooxygenase-1-dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction. J. Neurosci. 2013, 33(38):15248-15258.
    • (2013) J. Neurosci. , vol.33 , Issue.38 , pp. 15248-15258
    • Griffin, E.W.1    Skelly, D.T.2    Murray, C.L.3    Cunningham, C.4
  • 57
    • 37849185832 scopus 로고    scopus 로고
    • Elevated body mass index is associated with executive dysfunction in otherwise healthy adults
    • Gunstad J., Paul R.H., Cohen R.A., Tate D.F., Spitznagel M.B., Gordon E. Elevated body mass index is associated with executive dysfunction in otherwise healthy adults. Compr. Psychiatry 2007, 48(1):57-61.
    • (2007) Compr. Psychiatry , vol.48 , Issue.1 , pp. 57-61
    • Gunstad, J.1    Paul, R.H.2    Cohen, R.A.3    Tate, D.F.4    Spitznagel, M.B.5    Gordon, E.6
  • 58
    • 39749196262 scopus 로고    scopus 로고
    • Body mass index and neuropsychological function in healthy children and adolescents
    • Gunstad J., Spitznagel M.B., Paul R.H., Cohen R.A., Kohn M., Luyster F.S., et al. Body mass index and neuropsychological function in healthy children and adolescents. Appetite 2008, 50(2-3):246-251.
    • (2008) Appetite , vol.50 , Issue.2-3 , pp. 246-251
    • Gunstad, J.1    Spitznagel, M.B.2    Paul, R.H.3    Cohen, R.A.4    Kohn, M.5    Luyster, F.S.6
  • 59
    • 77952411923 scopus 로고    scopus 로고
    • Longitudinal examination of obesity and cognitive function: results from the Baltimore longitudinal study of aging
    • Gunstad J., Lhotsky A., Wendell C.R., Ferrucci L., Zonderman A.B. Longitudinal examination of obesity and cognitive function: results from the Baltimore longitudinal study of aging. Neuroepidemiology 2010, 34(4):222-229.
    • (2010) Neuroepidemiology , vol.34 , Issue.4 , pp. 222-229
    • Gunstad, J.1    Lhotsky, A.2    Wendell, C.R.3    Ferrucci, L.4    Zonderman, A.B.5
  • 60
    • 33745940760 scopus 로고    scopus 로고
    • Adiposity indices and dementia
    • Gustafson D. Adiposity indices and dementia. Lancet Neurol. 2006, 5(8):713-720.
    • (2006) Lancet Neurol. , vol.5 , Issue.8 , pp. 713-720
    • Gustafson, D.1
  • 61
  • 62
    • 8844235609 scopus 로고    scopus 로고
    • A 24-year follow-up of body mass index and cerebral atrophy
    • Gustafson D., Lissner L., Bengtsson C., Bjorkelund C., Skoog I. A 24-year follow-up of body mass index and cerebral atrophy. Neurology 2004, 63(10):1876-1881.
    • (2004) Neurology , vol.63 , Issue.10 , pp. 1876-1881
    • Gustafson, D.1    Lissner, L.2    Bengtsson, C.3    Bjorkelund, C.4    Skoog, I.5
  • 63
    • 72049088762 scopus 로고    scopus 로고
    • Adiposity indicators and dementia over 32years in Sweden
    • Gustafson D.R., Backman K., Waern M., Ostling S., Guo X., Zandi P., et al. Adiposity indicators and dementia over 32years in Sweden. Neurology 2009, 73(19):1559-1566.
    • (2009) Neurology , vol.73 , Issue.19 , pp. 1559-1566
    • Gustafson, D.R.1    Backman, K.2    Waern, M.3    Ostling, S.4    Guo, X.5    Zandi, P.6
  • 64
    • 84855781454 scopus 로고    scopus 로고
    • 37 years of body mass index and dementia: observations from the prospective population study of women in Gothenburg, Sweden
    • Gustafson D.R., Backman K., Joas E., Waern M., Ostling S., Guo X., et al. 37 years of body mass index and dementia: observations from the prospective population study of women in Gothenburg, Sweden. J. Alzheimers Dis. 2012, 28(1):163-171.
    • (2012) J. Alzheimers Dis. , vol.28 , Issue.1 , pp. 163-171
    • Gustafson, D.R.1    Backman, K.2    Joas, E.3    Waern, M.4    Ostling, S.5    Guo, X.6
  • 65
    • 84877148241 scopus 로고    scopus 로고
    • Biomarkers of vascular risk, systemic inflammation, and microvascular pathology and neuropsychiatric symptoms in Alzheimer's disease
    • Hall J.R., Wiechmann A.R., Johnson L.A., Edwards M., Barber R.C., Winter A.S., et al. Biomarkers of vascular risk, systemic inflammation, and microvascular pathology and neuropsychiatric symptoms in Alzheimer's disease. J. Alzheimers Dis. 2013, 35(2):363-371.
    • (2013) J. Alzheimers Dis. , vol.35 , Issue.2 , pp. 363-371
    • Hall, J.R.1    Wiechmann, A.R.2    Johnson, L.A.3    Edwards, M.4    Barber, R.C.5    Winter, A.S.6
  • 66
    • 25844457693 scopus 로고    scopus 로고
    • Obesity
    • Haslam D.W., James W.P. Obesity. Lancet 2005, 366(9492):1197-1209.
    • (2005) Lancet , vol.366 , Issue.9492 , pp. 1197-1209
    • Haslam, D.W.1    James, W.P.2
  • 67
    • 84857501672 scopus 로고    scopus 로고
    • Obesity and the hypothalamic-pituitary-adrenal axis in adolescent girls
    • Hillman J.B., Dorn L.D., Loucks T.L., Berga S.L. Obesity and the hypothalamic-pituitary-adrenal axis in adolescent girls. Metab., Clin. Exp. 2012, 61(3):341-348.
    • (2012) Metab., Clin. Exp. , vol.61 , Issue.3 , pp. 341-348
    • Hillman, J.B.1    Dorn, L.D.2    Loucks, T.L.3    Berga, S.L.4
  • 69
    • 43249105935 scopus 로고    scopus 로고
    • Paediatric obesity: a neurodevelopmental perspective
    • Holcke M., Marcus C., Gillberg C., Fernell E. Paediatric obesity: a neurodevelopmental perspective. Acta Paediatr. 2008, 97(6):819-821.
    • (2008) Acta Paediatr. , vol.97 , Issue.6 , pp. 819-821
    • Holcke, M.1    Marcus, C.2    Gillberg, C.3    Fernell, E.4
  • 70
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil G.S. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010, 140(6):900-917.
    • (2010) Cell , vol.140 , Issue.6 , pp. 900-917
    • Hotamisligil, G.S.1
  • 71
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • Hotamisligil G.S., Shargill N.S., Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259(5091):87-91.
    • (1993) Science , vol.259 , Issue.5091 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 72
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
    • Hotamisligil G.S., Arner P., Caro J.F., Atkinson R.L., Spiegelman B.M. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J. Clin. Invest. 1995, 95(5):2409-2415.
    • (1995) J. Clin. Invest. , vol.95 , Issue.5 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 73
    • 33750153292 scopus 로고    scopus 로고
    • Attenuation of leptin and insulin signaling by SOCS proteins
    • Howard J.K., Flier J.S. Attenuation of leptin and insulin signaling by SOCS proteins. Trends Endocrinol. Metab. 2006, 17(9):365-371.
    • (2006) Trends Endocrinol. Metab. , vol.17 , Issue.9 , pp. 365-371
    • Howard, J.K.1    Flier, J.S.2
  • 74
    • 27144515872 scopus 로고    scopus 로고
    • Brain atrophy rates predict subsequent clinical conversion in normal elderly and amnestic MCI
    • Jack C.R., Shiung M.M., Weigand S.D., O'Brien P.C., Gunter J.L., Boeve B.F., et al. Brain atrophy rates predict subsequent clinical conversion in normal elderly and amnestic MCI. Neurology 2005, 65(8):1227-1231.
    • (2005) Neurology , vol.65 , Issue.8 , pp. 1227-1231
    • Jack, C.R.1    Shiung, M.M.2    Weigand, S.D.3    O'Brien, P.C.4    Gunter, J.L.5    Boeve, B.F.6
  • 75
    • 26444458863 scopus 로고    scopus 로고
    • Central obesity and the aging brain
    • Jagust W., Harvey D., Mungas D., Haan M. Central obesity and the aging brain. Arch. Neurol. 2005, 62(10):1545-1548.
    • (2005) Arch. Neurol. , vol.62 , Issue.10 , pp. 1545-1548
    • Jagust, W.1    Harvey, D.2    Mungas, D.3    Haan, M.4
  • 76
    • 84861846116 scopus 로고    scopus 로고
    • Resveratrol attenuates obesity-associated peripheral and central inflammation and improves memory deficit in mice fed a high-fat diet
    • Jeon B.T., Jeong E.A., Shin H.J., Lee Y., Lee D.H., Kim H.J., et al. Resveratrol attenuates obesity-associated peripheral and central inflammation and improves memory deficit in mice fed a high-fat diet. Diabetes 2012, 61(6):1444-1454.
    • (2012) Diabetes , vol.61 , Issue.6 , pp. 1444-1454
    • Jeon, B.T.1    Jeong, E.A.2    Shin, H.J.3    Lee, Y.4    Lee, D.H.5    Kim, H.J.6
  • 78
    • 77954955083 scopus 로고    scopus 로고
    • High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model
    • Julien C., Tremblay C., Phivilay A., Berthiaume L., Emond V., Julien P., et al. High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model. Neurobiol. Aging 2010, 31(9):1516-1531.
    • (2010) Neurobiol. Aging , vol.31 , Issue.9 , pp. 1516-1531
    • Julien, C.1    Tremblay, C.2    Phivilay, A.3    Berthiaume, L.4    Emond, V.5    Julien, P.6
  • 79
    • 50449105836 scopus 로고    scopus 로고
    • Diet-induced obesity and spatial cognition in young male rats
    • Jurdak N., Lichtenstein A.H., Kanarek R.B. Diet-induced obesity and spatial cognition in young male rats. Nutr. Neurosci. 2008, 11(2):48-54.
    • (2008) Nutr. Neurosci. , vol.11 , Issue.2 , pp. 48-54
    • Jurdak, N.1    Lichtenstein, A.H.2    Kanarek, R.B.3
  • 80
    • 62449261168 scopus 로고    scopus 로고
    • Total and regional adiposity and cognitive change in older adults: the Health, Aging and Body Composition (ABC) study
    • Kanaya A.M., Lindquist K., Harris T.B., Launer L., Rosano C., Satterfield S., et al. Total and regional adiposity and cognitive change in older adults: the Health, Aging and Body Composition (ABC) study. Arch. Neurol. 2009, 66(3):329-335.
    • (2009) Arch. Neurol. , vol.66 , Issue.3 , pp. 329-335
    • Kanaya, A.M.1    Lindquist, K.2    Harris, T.B.3    Launer, L.4    Rosano, C.5    Satterfield, S.6
  • 81
    • 20544474210 scopus 로고    scopus 로고
    • Pathogen recognition with Toll-like receptors
    • Kawai T., Akira S. Pathogen recognition with Toll-like receptors. Curr. Opin. Immunol. 2005, 17(4):338-344.
    • (2005) Curr. Opin. Immunol. , vol.17 , Issue.4 , pp. 338-344
    • Kawai, T.1    Akira, S.2
  • 82
    • 0025935624 scopus 로고
    • Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging
    • Kerr D.S., Campbell L.W., Applegate M.D., Brodish A., Landfield P.W. Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging. J. Neurosci. 1991, 11(5):1316-1324.
    • (1991) J. Neurosci. , vol.11 , Issue.5 , pp. 1316-1324
    • Kerr, D.S.1    Campbell, L.W.2    Applegate, M.D.3    Brodish, A.4    Landfield, P.W.5
  • 83
    • 26444463825 scopus 로고    scopus 로고
    • Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease
    • Kivipelto M., Ngandu T., Fratiglioni L., Viitanen M., Kareholt I., Winblad B., et al. Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch. Neurol. 2005, 62(10):1556-1560.
    • (2005) Arch. Neurol. , vol.62 , Issue.10 , pp. 1556-1560
    • Kivipelto, M.1    Ngandu, T.2    Fratiglioni, L.3    Viitanen, M.4    Kareholt, I.5    Winblad, B.6
  • 84
    • 70349484212 scopus 로고    scopus 로고
    • MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity
    • Kleinridders A., Schenten D., Konner A.C., Belgardt B.F., Mauer J., Okamura T., et al. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab. 2009, 10(4):249-259.
    • (2009) Cell Metab. , vol.10 , Issue.4 , pp. 249-259
    • Kleinridders, A.1    Schenten, D.2    Konner, A.C.3    Belgardt, B.F.4    Mauer, J.5    Okamura, T.6
  • 85
    • 74549158255 scopus 로고    scopus 로고
    • No retrieval-induced forgetting under stress
    • Koessler S., Engler H., Riether C., Kissler J. No retrieval-induced forgetting under stress. Psychol. Sci. 2009, 20(11):1356-1363.
    • (2009) Psychol. Sci. , vol.20 , Issue.11 , pp. 1356-1363
    • Koessler, S.1    Engler, H.2    Riether, C.3    Kissler, J.4
  • 86
    • 33645125475 scopus 로고    scopus 로고
    • Cognitive function in normal-weight, overweight, and obese older adults: an analysis of the Advanced Cognitive Training for Independent and Vital Elderly cohort
    • Kuo H.K., Jones R.N., Milberg W.P., Tennstedt S., Talbot L., Morris J.N., et al. Cognitive function in normal-weight, overweight, and obese older adults: an analysis of the Advanced Cognitive Training for Independent and Vital Elderly cohort. J. Am. Geriatr. Soc. 2006, 54(1):97-103.
    • (2006) J. Am. Geriatr. Soc. , vol.54 , Issue.1 , pp. 97-103
    • Kuo, H.K.1    Jones, R.N.2    Milberg, W.P.3    Tennstedt, S.4    Talbot, L.5    Morris, J.N.6
  • 87
    • 84876572014 scopus 로고    scopus 로고
    • Detrimental effects of diet-induced obesity on tau pathology are independent of insulin resistance in tau transgenic mice
    • Leboucher A., Laurent C., Fernandez-Gomez F.J., Burnouf S., Troquier L., Eddarkaoui S., et al. Detrimental effects of diet-induced obesity on tau pathology are independent of insulin resistance in tau transgenic mice. Diabetes 2013, 62(5):1681-1688.
    • (2013) Diabetes , vol.62 , Issue.5 , pp. 1681-1688
    • Leboucher, A.1    Laurent, C.2    Fernandez-Gomez, F.J.3    Burnouf, S.4    Troquier, L.5    Eddarkaoui, S.6
  • 88
    • 53349129897 scopus 로고    scopus 로고
    • Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation
    • Lee J.W., Lee Y.K., Yuk D.Y., Choi D.Y., Ban S.B., Oh K.W., et al. Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation. J. Neuroinflamm. 2008, 5:37.
    • (2008) J. Neuroinflamm. , vol.5 , pp. 37
    • Lee, J.W.1    Lee, Y.K.2    Yuk, D.Y.3    Choi, D.Y.4    Ban, S.B.5    Oh, K.W.6
  • 89
    • 71849089826 scopus 로고    scopus 로고
    • Plasma amyloid-beta peptide levels correlate with adipocyte amyloid precursor protein gene expression in obese individuals
    • Lee Y.H., Martin J.M., Maple R.L., Tharp W.G., Pratley R.E. Plasma amyloid-beta peptide levels correlate with adipocyte amyloid precursor protein gene expression in obese individuals. Neuroendocrinology 2009, 90(4):383-390.
    • (2009) Neuroendocrinology , vol.90 , Issue.4 , pp. 383-390
    • Lee, Y.H.1    Martin, J.M.2    Maple, R.L.3    Tharp, W.G.4    Pratley, R.E.5
  • 90
    • 0037477629 scopus 로고    scopus 로고
    • Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway
    • Lehnardt S., Massillon L., Follett P., Jensen F.E., Ratan R., Rosenberg P.A., et al. Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proc. Nat. Acad. Sci. USA 2003, 100(14):8514-8519.
    • (2003) Proc. Nat. Acad. Sci. USA , vol.100 , Issue.14 , pp. 8514-8519
    • Lehnardt, S.1    Massillon, L.2    Follett, P.3    Jensen, F.E.4    Ratan, R.5    Rosenberg, P.A.6
  • 91
    • 0036963532 scopus 로고    scopus 로고
    • Increased amyloid-levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet
    • Levin-Allerhand J.A., Lominska C.E., Smith J.D. Increased amyloid-levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet. J. Nutr. Health Aging 2002, 6(5):315-319.
    • (2002) J. Nutr. Health Aging , vol.6 , Issue.5 , pp. 315-319
    • Levin-Allerhand, J.A.1    Lominska, C.E.2    Smith, J.D.3
  • 92
    • 48749091561 scopus 로고    scopus 로고
    • Overweight is associated with decreased cognitive functioning among school-age children and adolescents
    • Li Y., Dai Q., Jackson J.C., Zhang J. Overweight is associated with decreased cognitive functioning among school-age children and adolescents. Obesity 2008, 16(8):1809-1815.
    • (2008) Obesity , vol.16 , Issue.8 , pp. 1809-1815
    • Li, Y.1    Dai, Q.2    Jackson, J.C.3    Zhang, J.4
  • 94
    • 84898041036 scopus 로고    scopus 로고
    • Neurocognitive correlates of obesity and obesity-related behaviors in children and adolescents
    • Liang J., Matheson B.E., Kaye W.H., Boutelle K.N. Neurocognitive correlates of obesity and obesity-related behaviors in children and adolescents. Int. J. Obes. 2014, 38(4):494-506.
    • (2014) Int. J. Obes. , vol.38 , Issue.4 , pp. 494-506
    • Liang, J.1    Matheson, B.E.2    Kaye, W.H.3    Boutelle, K.N.4
  • 95
    • 77957086962 scopus 로고    scopus 로고
    • Role of microglia in neurotrauma
    • Loane D.J., Byrnes K.R. Role of microglia in neurotrauma. Neurotherapeutics 2010, 7(4):366-377.
    • (2010) Neurotherapeutics , vol.7 , Issue.4 , pp. 366-377
    • Loane, D.J.1    Byrnes, K.R.2
  • 96
    • 70849120493 scopus 로고    scopus 로고
    • Recent progress in the genetics of common obesity
    • Loos R.J. Recent progress in the genetics of common obesity. Br. J. Clin. Pharmacol. 2009, 68(6):811-829.
    • (2009) Br. J. Clin. Pharmacol. , vol.68 , Issue.6 , pp. 811-829
    • Loos, R.J.1
  • 97
    • 69349094004 scopus 로고    scopus 로고
    • CNS penetration of small molecules following local inflammation, widespread systemic inflammation or direct injury to the nervous system
    • Lu P., Gonzales C., Chen Y., Adedoyin A., Hummel M., Kennedy J.D., et al. CNS penetration of small molecules following local inflammation, widespread systemic inflammation or direct injury to the nervous system. Life Sci. 2009, 85(11-12):450-456.
    • (2009) Life Sci. , vol.85 , Issue.11-12 , pp. 450-456
    • Lu, P.1    Gonzales, C.2    Chen, Y.3    Adedoyin, A.4    Hummel, M.5    Kennedy, J.D.6
  • 98
    • 80053897594 scopus 로고    scopus 로고
    • Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IkappaB kinase beta/nuclear factor-kappaB-mediated inflammatory pathways in mice
    • Lu J., Wu D.M., Zheng Y.L., Hu B., Cheng W., Zhang Z.F., et al. Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IkappaB kinase beta/nuclear factor-kappaB-mediated inflammatory pathways in mice. Brain Behav. Immun. 2011, 25(8):1658-1667.
    • (2011) Brain Behav. Immun. , vol.25 , Issue.8 , pp. 1658-1667
    • Lu, J.1    Wu, D.M.2    Zheng, Y.L.3    Hu, B.4    Cheng, W.5    Zhang, Z.F.6
  • 99
    • 84888287660 scopus 로고    scopus 로고
    • Nox2-derived superoxide contributes to cerebral vascular dysfunction in diet-induced obesity
    • Lynch C.M., Kinzenbaw D.A., Chen X., Zhan S., Mezzetti E., Filosa J., et al. Nox2-derived superoxide contributes to cerebral vascular dysfunction in diet-induced obesity. Stroke 2013, 44(11):3195-3201.
    • (2013) Stroke , vol.44 , Issue.11 , pp. 3195-3201
    • Lynch, C.M.1    Kinzenbaw, D.A.2    Chen, X.3    Zhan, S.4    Mezzetti, E.5    Filosa, J.6
  • 100
    • 79959649105 scopus 로고    scopus 로고
    • Disinhibited eating in obese adolescents is associated with orbitofrontal volume reductions and executive dysfunction
    • Maayan L., Hoogendoorn C., Sweat V., Convit A. Disinhibited eating in obese adolescents is associated with orbitofrontal volume reductions and executive dysfunction. Obesity 2011, 19(7):1382-1387.
    • (2011) Obesity , vol.19 , Issue.7 , pp. 1382-1387
    • Maayan, L.1    Hoogendoorn, C.2    Sweat, V.3    Convit, A.4
  • 101
    • 79951810657 scopus 로고    scopus 로고
    • The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research?
    • MacQueen G., Frodl T. The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research?. Mol. Psychiatry 2011, 16(3):252-264.
    • (2011) Mol. Psychiatry , vol.16 , Issue.3 , pp. 252-264
    • MacQueen, G.1    Frodl, T.2
  • 102
    • 85058205901 scopus 로고    scopus 로고
    • Environmental enrichment ameliorated high-fat diet-induced Abeta deposition and memory deficit in APP transgenic mice
    • 1011 e1011-1023
    • Maesako M., Uemura K., Kubota M., Kuzuya A., Sasaki K., Asada M., et al. Environmental enrichment ameliorated high-fat diet-induced Abeta deposition and memory deficit in APP transgenic mice. Neurobiol. Aging 2012, 33(5). 1011 e1011-1023.
    • (2012) Neurobiol. Aging , vol.33 , Issue.5
    • Maesako, M.1    Uemura, K.2    Kubota, M.3    Kuzuya, A.4    Sasaki, K.5    Asada, M.6
  • 103
    • 84863310264 scopus 로고    scopus 로고
    • Exercise is more effective than diet control in preventing high fat diet-induced beta-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice
    • Maesako M., Uemura K., Kubota M., Kuzuya A., Sasaki K., Hayashida N., et al. Exercise is more effective than diet control in preventing high fat diet-induced beta-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice. J. Biol. Chem. 2012, 287(27):23024-23033.
    • (2012) J. Biol. Chem. , vol.287 , Issue.27 , pp. 23024-23033
    • Maesako, M.1    Uemura, K.2    Kubota, M.3    Kuzuya, A.4    Sasaki, K.5    Hayashida, N.6
  • 104
    • 0029120661 scopus 로고
    • Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: involvement of glucocorticoid secretion and excitatory amino acid receptors
    • Magarinos A.M., McEwen B.S. Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: involvement of glucocorticoid secretion and excitatory amino acid receptors. Neuroscience 1995, 69(1):89-98.
    • (1995) Neuroscience , vol.69 , Issue.1 , pp. 89-98
    • Magarinos, A.M.1    McEwen, B.S.2
  • 105
    • 84891824510 scopus 로고    scopus 로고
    • The effects of dietary saturated fat on basal hypothalamic neuroinflammation in rats
    • Maric T., Woodside B., Luheshi G.N. The effects of dietary saturated fat on basal hypothalamic neuroinflammation in rats. Brain Behav. Immun. 2014, 36:35-45.
    • (2014) Brain Behav. Immun. , vol.36 , pp. 35-45
    • Maric, T.1    Woodside, B.2    Luheshi, G.N.3
  • 106
    • 77950354771 scopus 로고    scopus 로고
    • Association between raised inflammatory markers and cognitive decline in elderly people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    • Marioni R.E., Strachan M.W., Reynolds R.M., Lowe G.D., Mitchell R.J., Fowkes F.G., et al. Association between raised inflammatory markers and cognitive decline in elderly people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. Diabetes 2010, 59(3):710-713.
    • (2010) Diabetes , vol.59 , Issue.3 , pp. 710-713
    • Marioni, R.E.1    Strachan, M.W.2    Reynolds, R.M.3    Lowe, G.D.4    Mitchell, R.J.5    Fowkes, F.G.6
  • 107
    • 0014435596 scopus 로고
    • Selective retention of corticosterone by limbic structures in rat brain
    • McEwen B.S., Weiss J.M., Schwartz L.S. Selective retention of corticosterone by limbic structures in rat brain. Nature 1968, 220(5170):911-912.
    • (1968) Nature , vol.220 , Issue.5170 , pp. 911-912
    • McEwen, B.S.1    Weiss, J.M.2    Schwartz, L.S.3
  • 108
    • 84855426656 scopus 로고    scopus 로고
    • Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice
    • McNay D.E., Briancon N., Kokoeva M.V., Maratos-Flier E., Flier J.S. Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. J. Clin. Invest. 2012, 122(1):142-152.
    • (2012) J. Clin. Invest. , vol.122 , Issue.1 , pp. 142-152
    • McNay, D.E.1    Briancon, N.2    Kokoeva, M.V.3    Maratos-Flier, E.4    Flier, J.S.5
  • 109
    • 58849149821 scopus 로고    scopus 로고
    • Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity
    • Milanski M., Degasperi G., Coope A., Morari J., Denis R., Cintra D.E., et al. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J. Neurosci. 2009, 29(2):359-370.
    • (2009) J. Neurosci. , vol.29 , Issue.2 , pp. 359-370
    • Milanski, M.1    Degasperi, G.2    Coope, A.3    Morari, J.4    Denis, R.5    Cintra, D.E.6
  • 110
    • 84884674647 scopus 로고    scopus 로고
    • Bariatric surgery patients exhibit improved memory function 12 months postoperatively
    • Miller L.A., Crosby R.D., Galioto R., Strain G., Devlin M.J., Wing R., et al. Bariatric surgery patients exhibit improved memory function 12 months postoperatively. Obes. Surg. 2013, 23(10):1527-1535.
    • (2013) Obes. Surg. , vol.23 , Issue.10 , pp. 1527-1535
    • Miller, L.A.1    Crosby, R.D.2    Galioto, R.3    Strain, G.4    Devlin, M.J.5    Wing, R.6
  • 111
    • 84884254622 scopus 로고    scopus 로고
    • Microglia and synapse interactions: fine tuning neural circuits and candidate molecules
    • Miyamoto A., Wake H., Moorhouse A.J., Nabekura J. Microglia and synapse interactions: fine tuning neural circuits and candidate molecules. Front. Cell. Neurosci. 2013, 7:70.
    • (2013) Front. Cell. Neurosci. , vol.7 , pp. 70
    • Miyamoto, A.1    Wake, H.2    Moorhouse, A.J.3    Nabekura, J.4
  • 112
    • 0037135258 scopus 로고    scopus 로고
    • A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning
    • Molteni R., Barnard R.J., Ying Z., Roberts C.K., Gomez-Pinilla F. A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience 2002, 112(4):803-814.
    • (2002) Neuroscience , vol.112 , Issue.4 , pp. 803-814
    • Molteni, R.1    Barnard, R.J.2    Ying, Z.3    Roberts, C.K.4    Gomez-Pinilla, F.5
  • 113
    • 0345189366 scopus 로고    scopus 로고
    • Inflammatory blockade restores adult hippocampal neurogenesis
    • Monje M.L., Toda H., Palmer T.D. Inflammatory blockade restores adult hippocampal neurogenesis. Science 2003, 302(5651):1760-1765.
    • (2003) Science , vol.302 , Issue.5651 , pp. 1760-1765
    • Monje, M.L.1    Toda, H.2    Palmer, T.D.3
  • 115
    • 52449087540 scopus 로고    scopus 로고
    • Limited Alzheimer-type neurodegeneration in experimental obesity and type 2 diabetes mellitus
    • Moroz N., Tong M., Longato L., Xu H., de la Monte S.M. Limited Alzheimer-type neurodegeneration in experimental obesity and type 2 diabetes mellitus. J. Alzheimers Dis. 2008, 15(1):29-44.
    • (2008) J. Alzheimers Dis. , vol.15 , Issue.1 , pp. 29-44
    • Moroz, N.1    Tong, M.2    Longato, L.3    Xu, H.4    de la Monte, S.M.5
  • 116
    • 77956298342 scopus 로고    scopus 로고
    • High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice. implications for decreased Nrf2 signaling
    • Morrison C.D., Pistell P.J., Ingram D.K., Johnson W.D., Liu Y., Fernandez-Kim S.O., et al. High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice. implications for decreased Nrf2 signaling. J. Neurochem. 2010, 114(6):1581-1589.
    • (2010) J. Neurochem. , vol.114 , Issue.6 , pp. 1581-1589
    • Morrison, C.D.1    Pistell, P.J.2    Ingram, D.K.3    Johnson, W.D.4    Liu, Y.5    Fernandez-Kim, S.O.6
  • 117
    • 62849098571 scopus 로고    scopus 로고
    • Alzheimer-type neuropathological changes in morbidly obese elderly individuals
    • Mrak R.E. Alzheimer-type neuropathological changes in morbidly obese elderly individuals. Clin. Neuropathol. 2009, 28(1):40-45.
    • (2009) Clin. Neuropathol. , vol.28 , Issue.1 , pp. 40-45
    • Mrak, R.E.1
  • 118
    • 33645082486 scopus 로고    scopus 로고
    • Potential inflammatory biomarkers in Alzheimer's disease
    • Mrak R.E., Griffin W.S. Potential inflammatory biomarkers in Alzheimer's disease. J. Alzheimers Dis. 2005, 8(4):369-375.
    • (2005) J. Alzheimers Dis. , vol.8 , Issue.4 , pp. 369-375
    • Mrak, R.E.1    Griffin, W.S.2
  • 119
    • 79954490068 scopus 로고    scopus 로고
    • Sex-dependent influences of obesity on cerebral white matter investigated by diffusion-tensor imaging
    • Mueller K., Anwander A., Moller H.E., Horstmann A., Lepsien J., Busse F., et al. Sex-dependent influences of obesity on cerebral white matter investigated by diffusion-tensor imaging. PLoS One 2011, 6(4):e18544.
    • (2011) PLoS One , vol.6 , Issue.4 , pp. e18544
    • Mueller, K.1    Anwander, A.2    Moller, H.E.3    Horstmann, A.4    Lepsien, J.5    Busse, F.6
  • 120
    • 33846223428 scopus 로고    scopus 로고
    • Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress
    • Nadanaka S., Okada T., Yoshida H., Mori K. Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress. Mol. Cell. Biol. 2007, 27(3):1027-1043.
    • (2007) Mol. Cell. Biol. , vol.27 , Issue.3 , pp. 1027-1043
    • Nadanaka, S.1    Okada, T.2    Yoshida, H.3    Mori, K.4
  • 121
    • 84856433589 scopus 로고    scopus 로고
    • Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010
    • Ogden C.L., Carroll M.D., Kit B.K., Flegal K.M. Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010. JAMA 2012, 307(5):483-490.
    • (2012) JAMA , vol.307 , Issue.5 , pp. 483-490
    • Ogden, C.L.1    Carroll, M.D.2    Kit, B.K.3    Flegal, K.M.4
  • 124
    • 80052633284 scopus 로고    scopus 로고
    • Synaptic pruning by microglia is necessary for normal brain development
    • Paolicelli R.C., Bolasco G., Pagani F., Maggi L., Scianni M., Panzanelli P., et al. Synaptic pruning by microglia is necessary for normal brain development. Science 2011, 333(6048):1456-1458.
    • (2011) Science , vol.333 , Issue.6048 , pp. 1456-1458
    • Paolicelli, R.C.1    Bolasco, G.2    Pagani, F.3    Maggi, L.4    Scianni, M.5    Panzanelli, P.6
  • 125
    • 84887198200 scopus 로고    scopus 로고
    • Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress
    • Patki G., Solanki N., Atrooz F., Allam F., Salim S. Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress. Brain Res. 2013, 1539:73-86.
    • (2013) Brain Res. , vol.1539 , pp. 73-86
    • Patki, G.1    Solanki, N.2    Atrooz, F.3    Allam, F.4    Salim, S.5
  • 126
    • 84871248750 scopus 로고    scopus 로고
    • Cognitive functions in middle aged individuals are related to metabolic disturbances and aerobic capacity: a cross-sectional study
    • Pedersen M., Pedersen K.K., Bruunsgaard H., Krabbe K.S., Thomsen C., Faerch K., et al. Cognitive functions in middle aged individuals are related to metabolic disturbances and aerobic capacity: a cross-sectional study. PLoS One 2012, 7(12):e51132.
    • (2012) PLoS One , vol.7 , Issue.12 , pp. e51132
    • Pedersen, M.1    Pedersen, K.K.2    Bruunsgaard, H.3    Krabbe, K.S.4    Thomsen, C.5    Faerch, K.6
  • 128
    • 0031720795 scopus 로고    scopus 로고
    • Is type II diabetes mellitus a disease of the innate immune system?
    • Pickup J.C., Crook M.A. Is type II diabetes mellitus a disease of the innate immune system?. Diabetologia 1998, 41(10):1241-1248.
    • (1998) Diabetologia , vol.41 , Issue.10 , pp. 1241-1248
    • Pickup, J.C.1    Crook, M.A.2
  • 129
    • 77249153620 scopus 로고    scopus 로고
    • Cognitive impairment following high fat diet consumption is associated with brain inflammation
    • Pistell P.J., Morrison C.D., Gupta S., Knight A.G., Keller J.N., Ingram D.K., et al. Cognitive impairment following high fat diet consumption is associated with brain inflammation. J. Neuroimmunol. 2010, 219(1-2):25-32.
    • (2010) J. Neuroimmunol. , vol.219 , Issue.1-2 , pp. 25-32
    • Pistell, P.J.1    Morrison, C.D.2    Gupta, S.3    Knight, A.G.4    Keller, J.N.5    Ingram, D.K.6
  • 130
    • 66149118129 scopus 로고    scopus 로고
    • Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet
    • Posey K.A., Clegg D.J., Printz R.L., Byun J., Morton G.J., Vivekanandan-Giri A., et al. Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am. J. Physiol. Endocrinol. Metab. 2009, 296(5):E1003-E1012.
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.296 , Issue.5 , pp. E1003-E1012
    • Posey, K.A.1    Clegg, D.J.2    Printz, R.L.3    Byun, J.4    Morton, G.J.5    Vivekanandan-Giri, A.6
  • 131
    • 84856021238 scopus 로고    scopus 로고
    • Amyloid precursor protein and proinflammatory changes are regulated in brain and adipose tissue in a murine model of high fat diet-induced obesity
    • Puig K.L., Floden A.M., Adhikari R., Golovko M.Y., Combs C.K. Amyloid precursor protein and proinflammatory changes are regulated in brain and adipose tissue in a murine model of high fat diet-induced obesity. PLoS One 2012, 7(1):e30378.
    • (2012) PLoS One , vol.7 , Issue.1 , pp. e30378
    • Puig, K.L.1    Floden, A.M.2    Adhikari, R.3    Golovko, M.Y.4    Combs, C.K.5
  • 132
    • 84888204785 scopus 로고    scopus 로고
    • Disruption of neurogenesis by hypothalamic inflammation in obesity or aging
    • Purkayastha S., Cai D. Disruption of neurogenesis by hypothalamic inflammation in obesity or aging. Rev. Endocr. Metab. Disord. 2013, 14(4):351-356.
    • (2013) Rev. Endocr. Metab. Disord. , vol.14 , Issue.4 , pp. 351-356
    • Purkayastha, S.1    Cai, D.2
  • 133
    • 38449099334 scopus 로고    scopus 로고
    • Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia
    • Qin H., Roberts K.L., Niyongere S.A., Cong Y., Elson C.O., Benveniste E.N. Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia. J. Immunol. 2007, 179(9):5966-5976.
    • (2007) J. Immunol. , vol.179 , Issue.9 , pp. 5966-5976
    • Qin, H.1    Roberts, K.L.2    Niyongere, S.A.3    Cong, Y.4    Elson, C.O.5    Benveniste, E.N.6
  • 134
    • 0031724136 scopus 로고    scopus 로고
    • Detrimental effects of chronic hypothalamic-pituitary-adrenal axis activation. From obesity to memory deficits
    • Raber J. Detrimental effects of chronic hypothalamic-pituitary-adrenal axis activation. From obesity to memory deficits. Mol. Neurobiol. 1998, 18(1):1-22.
    • (1998) Mol. Neurobiol. , vol.18 , Issue.1 , pp. 1-22
    • Raber, J.1
  • 136
    • 1842843860 scopus 로고    scopus 로고
    • Coupling endoplasmic reticulum stress to the cell death program
    • Rao R.V., Ellerby H.M., Bredesen D.E. Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ. 2004, 11(4):372-380.
    • (2004) Cell Death Differ. , vol.11 , Issue.4 , pp. 372-380
    • Rao, R.V.1    Ellerby, H.M.2    Bredesen, D.E.3
  • 137
    • 23444441331 scopus 로고    scopus 로고
    • Regional brain changes in aging healthy adults: general trends, individual differences and modifiers
    • Raz N., Lindenberger U., Rodrigue K.M., Kennedy K.M., Head D., Williamson A., et al. Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cereb. Cortex 2005, 15(11):1676-1689.
    • (2005) Cereb. Cortex , vol.15 , Issue.11 , pp. 1676-1689
    • Raz, N.1    Lindenberger, U.2    Rodrigue, K.M.3    Kennedy, K.M.4    Head, D.5    Williamson, A.6
  • 138
    • 84880679609 scopus 로고    scopus 로고
    • The relationship between executive function and obesity in children and adolescents: a systematic literature review
    • Reinert K.R., Po'e E.K., Barkin S.L. The relationship between executive function and obesity in children and adolescents: a systematic literature review. J. Obes. 2013, 2013:820956.
    • (2013) J. Obes. , vol.2013 , pp. 820956
    • Reinert, K.R.1    Po'e, E.K.2    Barkin, S.L.3
  • 139
    • 0032579752 scopus 로고    scopus 로고
    • Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6 receptor/interleukin-6 complex
    • Ringheim G.E., Szczepanik A.M., Petko W., Burgher K.L., Zhu S.Z., Chao C.C. Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6 receptor/interleukin-6 complex. Brain Res. Mol. Brain Res. 1998, 55(1):35-44.
    • (1998) Brain Res. Mol. Brain Res. , vol.55 , Issue.1 , pp. 35-44
    • Ringheim, G.E.1    Szczepanik, A.M.2    Petko, W.3    Burgher, K.L.4    Zhu, S.Z.5    Chao, C.C.6
  • 140
    • 84878524645 scopus 로고    scopus 로고
    • Pharmacological administration of the isoflavone daidzein enhances cell proliferation and reduces high fat diet-induced apoptosis and gliosis in the rat hippocampus
    • Rivera P., Perez-Martin M., Pavon F.J., Serrano A., Crespillo A., Cifuentes M., et al. Pharmacological administration of the isoflavone daidzein enhances cell proliferation and reduces high fat diet-induced apoptosis and gliosis in the rat hippocampus. PLoS One 2013, 8(5):e64750.
    • (2013) PLoS One , vol.8 , Issue.5 , pp. e64750
    • Rivera, P.1    Perez-Martin, M.2    Pavon, F.J.3    Serrano, A.4    Crespillo, A.5    Cifuentes, M.6
  • 141
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • Ron D., Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 2007, 8(7):519-529.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , Issue.7 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 142
    • 59649103005 scopus 로고    scopus 로고
    • Body mass index over the adult life course and cognition in late midlife: the Whitehall II Cohort Study
    • Sabia S., Kivimaki M., Shipley M.J., Marmot M.G., Singh-Manoux A. Body mass index over the adult life course and cognition in late midlife: the Whitehall II Cohort Study. Am. J. Clin. Nutr. 2009, 89(2):601-607.
    • (2009) Am. J. Clin. Nutr. , vol.89 , Issue.2 , pp. 601-607
    • Sabia, S.1    Kivimaki, M.2    Shipley, M.J.3    Marmot, M.G.4    Singh-Manoux, A.5
  • 143
    • 0021921612 scopus 로고
    • A mechanism for glucocorticoid toxicity in the hippocampus: increased neuronal vulnerability to metabolic insults
    • Sapolsky R.M. A mechanism for glucocorticoid toxicity in the hippocampus: increased neuronal vulnerability to metabolic insults. J. Neurosci. 1985, 5(5):1228-1232.
    • (1985) J. Neurosci. , vol.5 , Issue.5 , pp. 1228-1232
    • Sapolsky, R.M.1
  • 144
    • 0029739502 scopus 로고    scopus 로고
    • Why stress is bad for your brain
    • Sapolsky R.M. Why stress is bad for your brain. Science 1996, 273(5276):749-750.
    • (1996) Science , vol.273 , Issue.5276 , pp. 749-750
    • Sapolsky, R.M.1
  • 145
    • 0033800486 scopus 로고    scopus 로고
    • Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders
    • Sapolsky R.M. Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch. Gen. Psychiatry 2000, 57(10):925-935.
    • (2000) Arch. Gen. Psychiatry , vol.57 , Issue.10 , pp. 925-935
    • Sapolsky, R.M.1
  • 146
    • 0020646043 scopus 로고
    • Quantitative autoradiography of [3H]corticosterone receptors in rat brain
    • Sapolsky R.M., McEwen B.S., Rainbow T.C. Quantitative autoradiography of [3H]corticosterone receptors in rat brain. Brain Res. 1983, 271(2):331-334.
    • (1983) Brain Res. , vol.271 , Issue.2 , pp. 331-334
    • Sapolsky, R.M.1    McEwen, B.S.2    Rainbow, T.C.3
  • 147
    • 84875793795 scopus 로고    scopus 로고
    • Perinatal high fat diet alters glucocorticoid signaling and anxiety behavior in adulthood
    • Sasaki A., de Vega W.C., St-Cyr S., Pan P., McGowan P.O. Perinatal high fat diet alters glucocorticoid signaling and anxiety behavior in adulthood. Neuroscience 2013, 240:1-12.
    • (2013) Neuroscience , vol.240 , pp. 1-12
    • Sasaki, A.1    de Vega, W.C.2    St-Cyr, S.3    Pan, P.4    McGowan, P.O.5
  • 150
    • 68649091204 scopus 로고    scopus 로고
    • An expanded view of energy homeostasis: neural integration of metabolic, cognitive, and emotional drives to eat
    • Shin A.C., Zheng H., Berthoud H.R. An expanded view of energy homeostasis: neural integration of metabolic, cognitive, and emotional drives to eat. Physiol. Behav. 2009, 97(5):572-580.
    • (2009) Physiol. Behav. , vol.97 , Issue.5 , pp. 572-580
    • Shin, A.C.1    Zheng, H.2    Berthoud, H.R.3
  • 151
    • 84874249393 scopus 로고    scopus 로고
    • The immune system's involvement in obesity-driven type 2 diabetes
    • Shu C.J., Benoist C., Mathis D. The immune system's involvement in obesity-driven type 2 diabetes. Semin. Immunol. 2012, 24(6):436-442.
    • (2012) Semin. Immunol. , vol.24 , Issue.6 , pp. 436-442
    • Shu, C.J.1    Benoist, C.2    Mathis, D.3
  • 152
    • 33846577831 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain
    • Sokka A.L., Putkonen N., Mudo G., Pryazhnikov E., Reijonen S., Khiroug L., et al. Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain. J. Neurosci. 2007, 27(4):901-908.
    • (2007) J. Neurosci. , vol.27 , Issue.4 , pp. 901-908
    • Sokka, A.L.1    Putkonen, N.2    Mudo, G.3    Pryazhnikov, E.4    Reijonen, S.5    Khiroug, L.6
  • 153
    • 84904880636 scopus 로고    scopus 로고
    • Perinatal nutrition programs neuroimmune function long-term: mechanisms and implications
    • Spencer S.J. Perinatal nutrition programs neuroimmune function long-term: mechanisms and implications. Front. Neurosci. 2013, 7:144.
    • (2013) Front. Neurosci. , vol.7 , pp. 144
    • Spencer, S.J.1
  • 156
    • 0026463945 scopus 로고
    • Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome
    • Starkman M.N., Gebarski S.S., Berent S., Schteingart D.E. Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome. Biol. Psychiatry 1992, 32(9):756-765.
    • (1992) Biol. Psychiatry , vol.32 , Issue.9 , pp. 756-765
    • Starkman, M.N.1    Gebarski, S.S.2    Berent, S.3    Schteingart, D.E.4
  • 157
    • 12144268588 scopus 로고    scopus 로고
    • A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study
    • Stewart R., Masaki K., Xue Q.L., Peila R., Petrovitch H., White L.R., et al. A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study. Arch. Neurol. 2005, 62(1):55-60.
    • (2005) Arch. Neurol. , vol.62 , Issue.1 , pp. 55-60
    • Stewart, R.1    Masaki, K.2    Xue, Q.L.3    Peila, R.4    Petrovitch, H.5    White, L.R.6
  • 158
    • 39749137437 scopus 로고    scopus 로고
    • Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons
    • Stranahan A.M., Arumugam T.V., Cutler R.G., Lee K., Egan J.M., Mattson M.P. Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons. Nat. Neurosci. 2008, 11(3):309-317.
    • (2008) Nat. Neurosci. , vol.11 , Issue.3 , pp. 309-317
    • Stranahan, A.M.1    Arumugam, T.V.2    Cutler, R.G.3    Lee, K.4    Egan, J.M.5    Mattson, M.P.6
  • 159
    • 55549139200 scopus 로고    scopus 로고
    • Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats
    • Stranahan A.M., Norman E.D., Lee K., Cutler R.G., Telljohann R.S., Egan J.M., et al. Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus 2008, 18(11):1085-1088.
    • (2008) Hippocampus , vol.18 , Issue.11 , pp. 1085-1088
    • Stranahan, A.M.1    Norman, E.D.2    Lee, K.3    Cutler, R.G.4    Telljohann, R.S.5    Egan, J.M.6
  • 160
    • 79960563493 scopus 로고    scopus 로고
    • Diet-induced elevations in serum cholesterol are associated with alterations in hippocampal lipid metabolism and increased oxidative stress
    • Stranahan A.M., Cutler R.G., Button C., Telljohann R., Mattson M.P. Diet-induced elevations in serum cholesterol are associated with alterations in hippocampal lipid metabolism and increased oxidative stress. J. Neurochem. 2011, 118(4):611-615.
    • (2011) J. Neurochem. , vol.118 , Issue.4 , pp. 611-615
    • Stranahan, A.M.1    Cutler, R.G.2    Button, C.3    Telljohann, R.4    Mattson, M.P.5
  • 161
    • 84856521441 scopus 로고    scopus 로고
    • Anti-inflammatory effects of physical activity in relationship to improved cognitive status in humans and mouse models of Alzheimer's disease
    • Stranahan A.M., Martin B., Maudsley S. Anti-inflammatory effects of physical activity in relationship to improved cognitive status in humans and mouse models of Alzheimer's disease. Curr. Alzheimer Res. 2012, 9(1):86-92.
    • (2012) Curr. Alzheimer Res. , vol.9 , Issue.1 , pp. 86-92
    • Stranahan, A.M.1    Martin, B.2    Maudsley, S.3
  • 162
    • 58549095944 scopus 로고    scopus 로고
    • Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP×PS1 knock-in mice
    • Studzinski C.M., Li F., Bruce-Keller A.J., Fernandez-Kim S.O., Zhang L., Weidner A.M., et al. Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP×PS1 knock-in mice. J. Neurochem. 2009, 108(4):860-866.
    • (2009) J. Neurochem. , vol.108 , Issue.4 , pp. 860-866
    • Studzinski, C.M.1    Li, F.2    Bruce-Keller, A.J.3    Fernandez-Kim, S.O.4    Zhang, L.5    Weidner, A.M.6
  • 163
    • 79952264011 scopus 로고    scopus 로고
    • Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
    • Tabas I., Ron D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat. Cell Biol. 2011, 13(3):184-190.
    • (2011) Nat. Cell Biol. , vol.13 , Issue.3 , pp. 184-190
    • Tabas, I.1    Ron, D.2
  • 164
    • 39449125017 scopus 로고    scopus 로고
    • Relationship between body mass index and gray matter volume in 1428 healthy individuals
    • Taki Y., Kinomura S., Sato K., Inoue K., Goto R., Okada K., et al. Relationship between body mass index and gray matter volume in 1428 healthy individuals. Obesity 2008, 16(1):119-124.
    • (2008) Obesity , vol.16 , Issue.1 , pp. 119-124
    • Taki, Y.1    Kinomura, S.2    Sato, K.3    Inoue, K.4    Goto, R.5    Okada, K.6
  • 165
    • 0036167595 scopus 로고    scopus 로고
    • Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia
    • Tarkowski E., Issa R., Sjogren M., Wallin A., Blennow K., Tarkowski A., et al. Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia. Neurobiol. Aging 2002, 23(2):237-243.
    • (2002) Neurobiol. Aging , vol.23 , Issue.2 , pp. 237-243
    • Tarkowski, E.1    Issa, R.2    Sjogren, M.3    Wallin, A.4    Blennow, K.5    Tarkowski, A.6
  • 166
    • 77956013253 scopus 로고    scopus 로고
    • Minireview: inflammation and obesity pathogenesis: the hypothalamus heats up
    • Thaler J.P., Schwartz M.W. Minireview: inflammation and obesity pathogenesis: the hypothalamus heats up. Endocrinology 2010, 151(9):4109-4115.
    • (2010) Endocrinology , vol.151 , Issue.9 , pp. 4109-4115
    • Thaler, J.P.1    Schwartz, M.W.2
  • 168
    • 45249117903 scopus 로고    scopus 로고
    • High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice
    • Thirumangalakudi L., Prakasam A., Zhang R., Bimonte-Nelson H., Sambamurti K., Kindy M.S., et al. High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. J. Neurochem. 2008, 106(1):475-485.
    • (2008) J. Neurochem. , vol.106 , Issue.1 , pp. 475-485
    • Thirumangalakudi, L.1    Prakasam, A.2    Zhang, R.3    Bimonte-Nelson, H.4    Sambamurti, K.5    Kindy, M.S.6
  • 169
    • 0035876916 scopus 로고    scopus 로고
    • Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia
    • Tikka T.M., Koistinaho J.E. Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia. J. Immunol. 2001, 166(12):7527-7533.
    • (2001) J. Immunol. , vol.166 , Issue.12 , pp. 7527-7533
    • Tikka, T.M.1    Koistinaho, J.E.2
  • 170
    • 0035871840 scopus 로고    scopus 로고
    • Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
    • Tikka T., Fiebich B.L., Goldsteins G., Keinanen R., Koistinaho J. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J. Neurosci. 2001, 21(8):2580-2588.
    • (2001) J. Neurosci. , vol.21 , Issue.8 , pp. 2580-2588
    • Tikka, T.1    Fiebich, B.L.2    Goldsteins, G.3    Keinanen, R.4    Koistinaho, J.5
  • 171
    • 78649976052 scopus 로고    scopus 로고
    • Microglial interactions with synapses are modulated by visual experience
    • Tremblay M.E., Lowery R.L., Majewska A.K. Microglial interactions with synapses are modulated by visual experience. PLoS Biol. 2010, 8(11):e1000527.
    • (2010) PLoS Biol. , vol.8 , Issue.11 , pp. e1000527
    • Tremblay, M.E.1    Lowery, R.L.2    Majewska, A.K.3
  • 172
    • 84867581107 scopus 로고    scopus 로고
    • The association between systemic inflammation and cognitive performance in the elderly: the Sydney Memory and Ageing Study
    • Trollor J.N., Smith E., Agars E., Kuan S.A., Baune B.T., Campbell L., et al. The association between systemic inflammation and cognitive performance in the elderly: the Sydney Memory and Ageing Study. Age (Dordr) 2012, 34(5):1295-1308.
    • (2012) Age (Dordr) , vol.34 , Issue.5 , pp. 1295-1308
    • Trollor, J.N.1    Smith, E.2    Agars, E.3    Kuan, S.A.4    Baune, B.T.5    Campbell, L.6
  • 173
    • 84903578474 scopus 로고    scopus 로고
    • Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse Hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease
    • [Epub ahead of print]
    • Tucsek Z., Toth P., Sosnowska D., Gautam T., Mitschelen M., Koller A., et al. Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse Hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease. J. Gerontol. 2013, [Epub ahead of print].
    • (2013) J. Gerontol.
    • Tucsek, Z.1    Toth, P.2    Sosnowska, D.3    Gautam, T.4    Mitschelen, M.5    Koller, A.6
  • 175
    • 33745315287 scopus 로고    scopus 로고
    • S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration
    • Uehara T., Nakamura T., Yao D., Shi Z.Q., Gu Z., Ma Y., et al. S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature 2006, 441(7092):513-517.
    • (2006) Nature , vol.441 , Issue.7092 , pp. 513-517
    • Uehara, T.1    Nakamura, T.2    Yao, D.3    Shi, Z.Q.4    Gu, Z.5    Ma, Y.6
  • 176
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • Uysal K.T., Wiesbrock S.M., Marino M.W., Hotamisligil G.S. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997, 389(6651):610-614.
    • (1997) Nature , vol.389 , Issue.6651 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 181
    • 65249157852 scopus 로고    scopus 로고
    • Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals
    • Wake H., Moorhouse A.J., Jinno S., Kohsaka S., Nabekura J. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J. Neurosci. 2009, 29(13):3974-3980.
    • (2009) J. Neurosci. , vol.29 , Issue.13 , pp. 3974-3980
    • Wake, H.1    Moorhouse, A.J.2    Jinno, S.3    Kohsaka, S.4    Nabekura, J.5
  • 182
    • 29144436439 scopus 로고    scopus 로고
    • The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study
    • Ward M.A., Carlsson C.M., Trivedi M.A., Sager M.A., Johnson S.C. The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study. BMC Neurol. 2005, 5:23.
    • (2005) BMC Neurol. , vol.5 , pp. 23
    • Ward, M.A.1    Carlsson, C.M.2    Trivedi, M.A.3    Sager, M.A.4    Johnson, S.C.5
  • 184
    • 0347985272 scopus 로고    scopus 로고
    • Obesity-induced inflammatory changes in adipose tissue
    • Wellen K.E., Hotamisligil G.S. Obesity-induced inflammatory changes in adipose tissue. J. Clin. Invest. 2003, 112(12):1785-1788.
    • (2003) J. Clin. Invest. , vol.112 , Issue.12 , pp. 1785-1788
    • Wellen, K.E.1    Hotamisligil, G.S.2
  • 185
    • 64249122725 scopus 로고    scopus 로고
    • Body adiposity in late life and risk of dementia or cognitive impairment in a longitudinal community-based study
    • West N.A., Haan M.N. Body adiposity in late life and risk of dementia or cognitive impairment in a longitudinal community-based study. J. Gerontol. A Biol. Sci. Med. Sci. 2009, 64(1):103-109.
    • (2009) J. Gerontol. A Biol. Sci. Med. Sci. , vol.64 , Issue.1 , pp. 103-109
    • West, N.A.1    Haan, M.N.2
  • 186
    • 67349276670 scopus 로고    scopus 로고
    • Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet
    • White C.L., Pistell P.J., Purpera M.N., Gupta S., Fernandez-Kim S.O., Hise T.L., et al. Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet. Neurobiol. Dis. 2009, 35(1):3-13.
    • (2009) Neurobiol. Dis. , vol.35 , Issue.1 , pp. 3-13
    • White, C.L.1    Pistell, P.J.2    Purpera, M.N.3    Gupta, S.4    Fernandez-Kim, S.O.5    Hise, T.L.6
  • 189
    • 84908628848 scopus 로고    scopus 로고
    • Obesity and overweight.
    • WHO (2013). Obesity and overweight. http://www.who.int/.
    • (2013)
  • 190
    • 84868303198 scopus 로고    scopus 로고
    • Hypothalamic dysfunction in obesity
    • Williams L.M. Hypothalamic dysfunction in obesity. Proc. Nutr. Soc. 2012, 71(4):521-533.
    • (2012) Proc. Nutr. Soc. , vol.71 , Issue.4 , pp. 521-533
    • Williams, L.M.1
  • 191
    • 28444459843 scopus 로고    scopus 로고
    • Studies of the effects of high fat diets on cognitive function in a rat model
    • Winocur G., Greenwood C.E. Studies of the effects of high fat diets on cognitive function in a rat model. Neurobiol. Aging 2005, 26(Suppl. 1):46-49.
    • (2005) Neurobiol. Aging , vol.26 , pp. 46-49
    • Winocur, G.1    Greenwood, C.E.2
  • 192
    • 84901310699 scopus 로고    scopus 로고
    • Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain
    • [Epub ahead of print]
    • Wohleb E.S., McKim D.B., Shea D.T., Powell N.D., Tarr A.J., Sheridan J.F., et al. Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain. Biol. Psychiatry 2013, [Epub ahead of print]. 10.1016/j.biopsych.2013.11.029.
    • (2013) Biol. Psychiatry
    • Wohleb, E.S.1    McKim, D.B.2    Shea, D.T.3    Powell, N.D.4    Tarr, A.J.5    Sheridan, J.F.6
  • 193
    • 84882596593 scopus 로고    scopus 로고
    • Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior
    • Wohleb E.S., Powell N.D., Godbout J.P., Sheridan J.F. Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior. J. Neurosci. 2013, 33(34):13820-13833.
    • (2013) J. Neurosci. , vol.33 , Issue.34 , pp. 13820-13833
    • Wohleb, E.S.1    Powell, N.D.2    Godbout, J.P.3    Sheridan, J.F.4
  • 194
    • 0025168942 scopus 로고
    • Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons
    • Woolley C.S., Gould E., McEwen B.S. Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons. Brain Res. 1990, 531(1-2):225-231.
    • (1990) Brain Res. , vol.531 , Issue.1-2 , pp. 225-231
    • Woolley, C.S.1    Gould, E.2    McEwen, B.S.3
  • 195
    • 0012850301 scopus 로고    scopus 로고
    • A saturated-fat diet aggravates the outcome of traumatic brain injury on hippocampal plasticity and cognitive function by reducing brain-derived neurotrophic factor
    • Wu A., Molteni R., Ying Z., Gomez-Pinilla F. A saturated-fat diet aggravates the outcome of traumatic brain injury on hippocampal plasticity and cognitive function by reducing brain-derived neurotrophic factor. Neuroscience 2003, 119(2):365-375.
    • (2003) Neuroscience , vol.119 , Issue.2 , pp. 365-375
    • Wu, A.1    Molteni, R.2    Ying, Z.3    Gomez-Pinilla, F.4
  • 196
    • 0142091830 scopus 로고    scopus 로고
    • Differential neuronal activation in the hypothalamic paraventricular nucleus and autonomic/neuroendocrine responses to I.C.V. endotoxin
    • Xia Y., Krukoff T.L. Differential neuronal activation in the hypothalamic paraventricular nucleus and autonomic/neuroendocrine responses to I.C.V. endotoxin. Neuroscience 2003, 121(1):219-231.
    • (2003) Neuroscience , vol.121 , Issue.1 , pp. 219-231
    • Xia, Y.1    Krukoff, T.L.2
  • 197
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H., Barnes G.T., Yang Q., Tan G., Yang D., Chou C.J., et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 2003, 112(12):1821-1830.
    • (2003) J. Clin. Invest. , vol.112 , Issue.12 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3    Tan, G.4    Yang, D.5    Chou, C.J.6
  • 198
    • 84867144608 scopus 로고    scopus 로고
    • Obesity and metabolic syndrome and functional and structural brain impairments in adolescence
    • Yau P.L., Castro M.G., Tagani A., Tsui W.H., Convit A. Obesity and metabolic syndrome and functional and structural brain impairments in adolescence. Pediatrics 2012, 130(4):e856-e864.
    • (2012) Pediatrics , vol.130 , Issue.4 , pp. e856-e864
    • Yau, P.L.1    Castro, M.G.2    Tagani, A.3    Tsui, W.H.4    Convit, A.5
  • 199
    • 84878767675 scopus 로고    scopus 로고
    • IL-1beta and TNF-alpha induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase
    • Ye L., Huang Y., Zhao L., Li Y., Sun L., Zhou Y., et al. IL-1beta and TNF-alpha induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase. J. Neurochem. 2013, 125(6):897-908.
    • (2013) J. Neurochem. , vol.125 , Issue.6 , pp. 897-908
    • Ye, L.1    Huang, Y.2    Zhao, L.3    Li, Y.4    Sun, L.5    Zhou, Y.6
  • 200
    • 84860707186 scopus 로고    scopus 로고
    • Relation of regional gray and white matter volumes to current BMI and future increases in BMI: a prospective MRI study
    • Yokum S., Ng J., Stice E. Relation of regional gray and white matter volumes to current BMI and future increases in BMI: a prospective MRI study. Int. J. Obes. 2012, 36(5):656-664.
    • (2012) Int. J. Obes. , vol.36 , Issue.5 , pp. 656-664
    • Yokum, S.1    Ng, J.2    Stice, E.3
  • 201
    • 11844263385 scopus 로고    scopus 로고
    • High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex
    • Zhang X., Dong F., Ren J., Driscoll M.J., Culver B. High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex. Exp. Neurol. 2005, 191(2):318-325.
    • (2005) Exp. Neurol. , vol.191 , Issue.2 , pp. 318-325
    • Zhang, X.1    Dong, F.2    Ren, J.3    Driscoll, M.J.4    Culver, B.5
  • 202
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
    • Zhang X., Zhang G., Zhang H., Karin M., Bai H., Cai D. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 2008, 135(1):61-73.
    • (2008) Cell , vol.135 , Issue.1 , pp. 61-73
    • Zhang, X.1    Zhang, G.2    Zhang, H.3    Karin, M.4    Bai, H.5    Cai, D.6
  • 203
    • 84881219156 scopus 로고    scopus 로고
    • Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: implications for studying obesity-brain interactions in mice
    • Zhang L., Dasuri K., Fernandez-Kim S.O., Bruce-Keller A.J., Freeman L.R., Pepping J.K., et al. Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: implications for studying obesity-brain interactions in mice. Biochim. Biophys. Acta 2013, 1832(9):1456-1462.
    • (2013) Biochim. Biophys. Acta , vol.1832 , Issue.9 , pp. 1456-1462
    • Zhang, L.1    Dasuri, K.2    Fernandez-Kim, S.O.3    Bruce-Keller, A.J.4    Freeman, L.R.5    Pepping, J.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.