메뉴 건너뛰기




Volumn 8, Issue 3, 2005, Pages 269-282

Plasma Aβ42 correlates positively with increased body fat in healthy individuals

Author keywords

AD, Alzheimer's disease; APOE 4, Apolipoprotein E epsilon 4 allele; A , amyloid beta protein; BMI, body mass index; CRP, C reactive protein; FM, Fat Mass; HDL, High density lipoprotein; IL, interleukin; LDL, Low density Lipoprotein

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; BIOLOGICAL MARKER; C REACTIVE PROTEIN; HIGH DENSITY LIPOPROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PEPTIDE FRAGMENT;

EID: 33644592540     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2005-8305     Document Type: Article
Times cited : (63)

References (79)
  • 1
    • 0029671454 scopus 로고    scopus 로고
    • Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein
    • S. Bodovitz and W.L. Klein, Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein, J Biol Chem 271 (1996), 4436-4440.
    • (1996) J Biol Chem , vol.271 , pp. 4436-4440
    • Bodovitz, S.1    Klein, W.L.2
  • 2
    • 0020534878 scopus 로고
    • Secretion and hepatic extraction of insulin in nondiabetic, obese, aged subjects
    • E. Bonora, C. Coscelli and U. Butturini, Secretion and hepatic extraction of insulin in nondiabetic, obese, aged subjects, J Am Geriatr Soc 31 (1983), 333-337.
    • (1983) J Am Geriatr Soc , vol.31 , pp. 333-337
    • Bonora, E.1    Coscelli, C.2    Butturini, U.3
  • 3
    • 0020539930 scopus 로고
    • Decreased hepatic insulin extraction in subjects with mild glucose intolerance
    • E. Bonora, I. Zavaroni, C. Coscelli and U. Butturini, Decreased hepatic insulin extraction in subjects with mild glucose intolerance, Metabolism 32 (1983), 438-446.
    • (1983) Metabolism , vol.32 , pp. 438-446
    • Bonora, E.1    Zavaroni, I.2    Coscelli, C.3    Butturini, U.4
  • 5
    • 0026448114 scopus 로고
    • Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor
    • J.D. Buxbaum, M. Oishi, H.I. Chen, R. Pinkas-Kramarski, E.A. Jaffe, S.E. Gandy and P. Greengard, Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor, Proc Natl Acad Sci USA 89 (1992), 10075-10078.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10075-10078
    • Buxbaum, J.D.1    Oishi, M.2    Chen, H.I.3    Pinkas-Kramarski, R.4    Jaffe, E.A.5    Gandy, S.E.6    Greengard, P.7
  • 6
    • 0041385937 scopus 로고    scopus 로고
    • Cerebrovascular risk factors in Alzheimer's disease: Brain hemodynamics and pharmacogenomic implications
    • R. Cacabelos, L. Fernandez-Novoa, V. Lombardi, L. Corzo, V. Pichel and Y. Kubota, Cerebrovascular risk factors in Alzheimer's disease: brain hemodynamics and pharmacogenomic implications, Neurol Res 25 (2003), 567-580.
    • (2003) Neurol Res , vol.25 , pp. 567-580
    • Cacabelos, R.1    Fernandez-Novoa, L.2    Lombardi, V.3    Corzo, L.4    Pichel, V.5    Kubota, Y.6
  • 9
    • 0033566370 scopus 로고    scopus 로고
    • Lipoprotein effects on Abeta accumulation and degradation by microglia in vitro
    • G.M. Cole, W. Beech, S.A. Frautschy, J. Sigel, C. Glasgow and M.D. Ard, Lipoprotein effects on Abeta accumulation and degradation by microglia in vitro, J Neurosci Res 57 (1999), 504-520.
    • (1999) J Neurosci Res , vol.57 , pp. 504-520
    • Cole, G.M.1    Beech, W.2    Frautschy, S.A.3    Sigel, J.4    Glasgow, C.5    Ard, M.D.6
  • 14
    • 0031660868 scopus 로고    scopus 로고
    • Expert panel on the identification, evaluation and treatment of overweight and obesity in adults, Clinical guidelines on the identification, Evaluation, and treatment of overweight and obesity in adults
    • Expert panel on the identification, evaluation and treatment of overweight and obesity in adults, Clinical guidelines on the identification, Evaluation, and treatment of overweight and obesity in adults, Am J Clin Nutr 68 (1998), 899-917.
    • (1998) Am J Clin Nutr , vol.68 , pp. 899-917
  • 15
    • 0032575852 scopus 로고    scopus 로고
    • Expert panel on the identification, evaluation and treatment of overweight and obesity in adults, Executive summary of clinical guidelines on the identifiaction, evaluation and treatment of overweight and obesity in adults
    • Expert panel on the identification, evaluation and treatment of overweight and obesity in adults, Executive summary of clinical guidelines on the identifiaction, evaluation and treatment of overweight and obesity in adults, Arch Intern Med 158 (1998), 1855-1867.
    • (1998) Arch Intern Med , vol.158 , pp. 1855-1867
  • 17
    • 0034604248 scopus 로고    scopus 로고
    • Chronic subclinical inflammation as part of the insulin resistance syndrome: The Insulin Resistance Atherosclerosis Study (IRAS)
    • A. Festa, R. D'Agostino, Jr., G. Howard, L. Mykkanen, R.P. Tracy and S.M. Haffner, Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS), Circulation 102 (2000), 42-47.
    • (2000) Circulation , vol.102 , pp. 42-47
    • Festa, A.1    D'Agostino Jr., R.2    Howard, G.3    Mykkanen, L.4    Tracy, R.P.5    Haffner, S.M.6
  • 19
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without the use of prearative ultracentrifuge
    • W.T. Friedewald, R.I. Levy and D.S. Fredrickson, Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without the use of prearative ultracentrifuge, Clin Chem 18 (1972), 499-502.
    • (1972) Clin Chem , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 20
    • 0035871641 scopus 로고    scopus 로고
    • Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling
    • L. Gasparini, G.K. Gouras, R. Wang, R.S. Gross, M.F. Beal, P. Greengard and H. Xu, Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling, J Neurosci 21 (2001), 2561-2570.
    • (2001) J Neurosci , vol.21 , pp. 2561-2570
    • Gasparini, L.1    Gouras, G.K.2    Wang, R.3    Gross, R.S.4    Beal, M.F.5    Greengard, P.6    Xu, H.7
  • 21
    • 4644338458 scopus 로고    scopus 로고
    • Circulating mononuclear cells in the obese are in a proinflammatory state
    • H. Ghanim, A. Aljada, D. Hofmeyer, T. Syed, P. Mohanty and P. Dandona, Circulating mononuclear cells in the obese are in a proinflammatory state, Circulation 110 (2004), 1564-1571.
    • (2004) Circulation , vol.110 , pp. 1564-1571
    • Ghanim, H.1    Aljada, A.2    Hofmeyer, D.3    Syed, T.4    Mohanty, P.5    Dandona, P.6
  • 23
  • 24
    • 0141835015 scopus 로고    scopus 로고
    • Insulin resistance, inflammation, and the prediabetic state
    • S.M. Haffner, Insulin resistance, inflammation, and the prediabetic state, Am J Cardiol 92 (2003), 18J-26J.
    • (2003) Am J Cardiol , vol.92
    • Haffner, S.M.1
  • 25
    • 0031054058 scopus 로고    scopus 로고
    • Production of C-reactive protein and risk of coronary events in stable and unstable angina
    • European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group
    • F. Haverkate, S.G. Thompson, S.D. Pyke, J.R. Gallimore and M.B. Pepys, Production of C-reactive protein and risk of coronary events in stable and unstable angina. European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group, Lancet 349 (1997), 462-466.
    • (1997) Lancet , vol.349 , pp. 462-466
    • Haverkate, F.1    Thompson, S.G.2    Pyke, S.D.3    Gallimore, J.R.4    Pepys, M.B.5
  • 26
    • 0025257612 scopus 로고
    • Restriction isotyping of human apolipoprotein e by gene amplification and cleavage with HhaI
    • J.E. Hixson and D.T. Vernier, Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI, J Lipid Res 3 (1990), 545-548.
    • (1990) J Lipid Res , vol.3 , pp. 545-548
    • Hixson, J.E.1    Vernier, D.T.2
  • 28
    • 0029986869 scopus 로고    scopus 로고
    • Occurrence of interleukin-6 in cortical plaques of Alzheimer's disease patients may precede transformation of diffuse into neuritic plaques
    • M. Hull, M. Berger, B. Volk and J. Bauer, Occurrence of interleukin-6 in cortical plaques of Alzheimer's disease patients may precede transformation of diffuse into neuritic plaques, Ann N Y Acad Sci 777 (1996), 205-212.
    • (1996) Ann N Y Acad Sci , vol.777 , pp. 205-212
    • Hull, M.1    Berger, M.2    Volk, B.3    Bauer, J.4
  • 31
    • 8744309820 scopus 로고    scopus 로고
    • Weight reduction, but not a moderate intake of fish oil, lowers concentrations of inflammatory markers and PAI-1 antigen in obese men during the fasting and postprandial state
    • A. Jellema, J. Plat and R.P. Mensink, Weight reduction, but not a moderate intake of fish oil, lowers concentrations of inflammatory markers and PAI-1 antigen in obese men during the fasting and postprandial state, Eur J Clin Invest 34 (2004), 766-773.
    • (2004) Eur J Clin Invest , vol.34 , pp. 766-773
    • Jellema, A.1    Plat, J.2    Mensink, R.P.3
  • 32
    • 33644606810 scopus 로고    scopus 로고
    • E.P. Jonhson, American College of Sports Medicine Lippincott Williams & Wilkins, Philadelphia, 2000
    • E.P. Jonhson, American College of Sports Medicine Lippincott Williams & Wilkins, Philadelphia, 2000.
  • 33
    • 7744226116 scopus 로고    scopus 로고
    • Serum levels of interleukin-6 and C-reactive protein correlate with body mass index across the broad range of obesity
    • L. Khaodhiar, P.R. Ling, G.L. Blackburn and B.R. Bistrian, Serum levels of interleukin-6 and C-reactive protein correlate with body mass index across the broad range of obesity, JPEN J Parenter Enteral Nutr 28 (2004), 410-415.
    • (2004) JPEN J Parenter Enteral Nutr , vol.28 , pp. 410-415
    • Khaodhiar, L.1    Ling, P.R.2    Blackburn, G.L.3    Bistrian, B.R.4
  • 34
    • 0032923669 scopus 로고    scopus 로고
    • C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: Results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992
    • W. Koenig, M. Sund, M. Frohlich, H.G. Fischer, H. Lowel, A. Doring, W.L. Hutchinson and M.B. Pepys, C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992, Circulation 99 (1999), 237-242.
    • (1999) Circulation , vol.99 , pp. 237-242
    • Koenig, W.1    Sund, M.2    Frohlich, M.3    Fischer, H.G.4    Lowel, H.5    Doring, A.6    Hutchinson, W.L.7    Pepys, M.B.8
  • 35
    • 2542492541 scopus 로고    scopus 로고
    • Lipids and lipoproteins in patients with type 2 diabetes
    • R.M. Krauss, Lipids and lipoproteins in patients with type 2 diabetes, Diabetes Care 27 (2004), 1496-1504.
    • (2004) Diabetes Care , vol.27 , pp. 1496-1504
    • Krauss, R.M.1
  • 37
    • 0035399887 scopus 로고    scopus 로고
    • Insulin-degrading enzyme: Embarking on amyloid destruction
    • I.V. Kurochkin, Insulin-degrading enzyme: embarking on amyloid destruction, Trends Biochem Sci 26 (2001), 421-425.
    • (2001) Trends Biochem Sci , vol.26 , pp. 421-425
    • Kurochkin, I.V.1
  • 38
    • 0028176821 scopus 로고
    • Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme
    • I.V. Kurochkin and S. Goto, Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme, FEBS Lett 345 (1994), 33-37.
    • (1994) FEBS Lett , vol.345 , pp. 33-37
    • Kurochkin, I.V.1    Goto, S.2
  • 39
    • 9844229370 scopus 로고    scopus 로고
    • Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: Cross sectional population based study
    • J. Kuusisto, K. Koivisto, L. Mykkanen, E.L. Helkala, M. Vanhanen, T. Hanninen, K. Kervinen, Y.A. Kesaniemi, P.J. Riekkinen and M. Laakso, Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study, Bmj 315 (1997), 1045-1049.
    • (1997) Bmj , vol.315 , pp. 1045-1049
    • Kuusisto, J.1    Koivisto, K.2    Mykkanen, L.3    Helkala, E.L.4    Vanhanen, M.5    Hanninen, T.6    Kervinen, K.7    Kesaniemi, Y.A.8    Riekkinen, P.J.9    Laakso, M.10
  • 40
    • 14544267750 scopus 로고    scopus 로고
    • The relationship between body composition and muscle power output in men and women with obesity
    • C.L. Lafortuna, F. Agosti, P.G. Marinone, N. Marazzi and A. Sartorio, The relationship between body composition and muscle power output in men and women with obesity, J Endocrinol Invest 27 (2004), 854-861.
    • (2004) J Endocrinol Invest , vol.27 , pp. 854-861
    • Lafortuna, C.L.1    Agosti, F.2    Marinone, P.G.3    Marazzi, N.4    Sartorio, A.5
  • 42
    • 0037345672 scopus 로고    scopus 로고
    • Expanding the association between the APOE gene and the risk of Alzheimer's disease: Possible roles for APOE promoter polymorphisms and alterations in APOE transcription
    • S.M. Laws, E. Hone, S. Gandy and R.N. Martins, Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription, J Neurochem 84 (2003), 1215-1236.
    • (2003) J Neurochem , vol.84 , pp. 1215-1236
    • Laws, S.M.1    Hone, E.2    Gandy, S.3    Martins, R.N.4
  • 43
    • 10344238086 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway
    • Y.F. Liao, B.J. Wang, H.T. Cheng, L.H. Kuo and M.S. Wolfe, Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway, J Biol Chem 279 (2004), 49523-49532.
    • (2004) J Biol Chem , vol.279 , pp. 49523-49532
    • Liao, Y.F.1    Wang, B.J.2    Cheng, H.T.3    Kuo, L.H.4    Wolfe, M.S.5
  • 44
    • 0036334166 scopus 로고    scopus 로고
    • Caloric intake and the risk of Alzheimer disease
    • J.A. Luchsinger, M.X. Tang, S. Shea and R. Mayeux, Caloric intake and the risk of Alzheimer disease, Arch Neurol 59 (2002), 1258-1263.
    • (2002) Arch Neurol , vol.59 , pp. 1258-1263
    • Luchsinger, J.A.1    Tang, M.X.2    Shea, S.3    Mayeux, R.4
  • 45
    • 5344256250 scopus 로고    scopus 로고
    • Hyperinsulinemia and risk of Alzheimer disease
    • J.A. Luchsinger, M.X. Tang, S. Shea and R. Mayeux, Hyperinsulinemia and risk of Alzheimer disease, Neurology 63 (2004), 1187-1192.
    • (2004) Neurology , vol.63 , pp. 1187-1192
    • Luchsinger, J.A.1    Tang, M.X.2    Shea, S.3    Mayeux, R.4
  • 46
    • 0242412140 scopus 로고    scopus 로고
    • Plasma A[beta]40 and A[beta]42 and Alzheimer's disease: Relation to age, mortality, and risk
    • R. Mayeux, L.S. Honig, M.X. Tang, J. Manly, Y. Stern, N. Schupf and P.D. Mehta, Plasma A[beta]40 and A[beta]42 and Alzheimer's disease: relation to age, mortality, and risk, Neurology 61 (2003), 1185-1190.
    • (2003) Neurology , vol.61 , pp. 1185-1190
    • Mayeux, R.1    Honig, L.S.2    Tang, M.X.3    Manly, J.4    Stern, Y.5    Schupf, N.6    Mehta, P.D.7
  • 48
    • 0029811901 scopus 로고    scopus 로고
    • Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies
    • P.L. McGeer, M. Schulzer and E.G. McGeer, Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies, Neurology 47 (1996), 425-432.
    • (1996) Neurology , vol.47 , pp. 425-432
    • McGeer, P.L.1    Schulzer, M.2    McGeer, E.G.3
  • 50
    • 0033975837 scopus 로고    scopus 로고
    • Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease
    • P.D. Mehta, T. Pirttila, S.P. Mehta, E.A. Sersen, P.S. Aisen and H.M. Wisniewski, Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease, Arch Neurol 57 (2000), 100-105.
    • (2000) Arch Neurol , vol.57 , pp. 100-105
    • Mehta, P.D.1    Pirttila, T.2    Mehta, S.P.3    Sersen, E.A.4    Aisen, P.S.5    Wisniewski, H.M.6
  • 51
    • 0034594467 scopus 로고    scopus 로고
    • Decreased high-density lipoprotein cholesterol and serum apolipoprotein AI concentrations are highly correlated with the severity of Alzheimer's disease
    • A. Merched, Y. Xia, S. Visvikis, J.M. Serot and G. Siest, Decreased high-density lipoprotein cholesterol and serum apolipoprotein AI concentrations are highly correlated with the severity of Alzheimer's disease, Neurobiol Aging 21 (2000), 27-30.
    • (2000) Neurobiol Aging , vol.21 , pp. 27-30
    • Merched, A.1    Xia, Y.2    Visvikis, S.3    Serot, J.M.4    Siest, G.5
  • 52
    • 0034594467 scopus 로고    scopus 로고
    • Decreased high-density lipoprotein cholesterol and serum apolipoprotein AI concentrations are highly correlated with the severity of Alzheimer's disease HDL phospholipid: A natural inhibitor of Alzheimer's amyloid beta-fibrillogenesis?
    • A. Merched, Y. Xia, S. Visvikis, J.M. Serot, G. Siest, A.R. Koudinov, N.V. Koudinova, T.T. Berezov and Y.D. Ivanov, Decreased high-density lipoprotein cholesterol and serum apolipoprotein AI concentrations are highly correlated with the severity of Alzheimer's disease HDL phospholipid: a natural inhibitor of Alzheimer's amyloid beta-fibrillogenesis? Neurobiol Aging 21 (2000), 27-30.
    • (2000) Neurobiol Aging , vol.21 , pp. 27-30
    • Merched, A.1    Xia, Y.2    Visvikis, S.3    Serot, J.M.4    Siest, G.5    Koudinov, A.R.6    Koudinova, N.V.7    Berezov, T.T.8    Ivanov, Y.D.9
  • 53
    • 0032468707 scopus 로고    scopus 로고
    • Possible link between lipid metabolism and cerebral amyloid angiopathy in Alzheimer's disease: A role for high-density lipoproteins?
    • M. Mulder and D. Terwel, Possible link between lipid metabolism and cerebral amyloid angiopathy in Alzheimer's disease: A role for high-density lipoproteins? Haemostasis 28 (1998), 174-194.
    • (1998) Haemostasis , vol.28 , pp. 174-194
    • Mulder, M.1    Terwel, D.2
  • 54
    • 0038117796 scopus 로고    scopus 로고
    • Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
    • J. Naslund, V. Haroutunian, R. Mohs, K.L. Davis, P. Davies, P. Greengard and J.D. Buxbaum, Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline, Jama 283 (2000), 1571-1577.
    • (2000) Jama , vol.283 , pp. 1571-1577
    • Naslund, J.1    Haroutunian, V.2    Mohs, R.3    Davis, K.L.4    Davies, P.5    Greengard, P.6    Buxbaum, J.D.7
  • 57
    • 0034595080 scopus 로고    scopus 로고
    • High density lipoprotein inhibits assembly of amyloid beta-peptides into fibrils
    • O.F. Olesen and L. Dago, High density lipoprotein inhibits assembly of amyloid beta-peptides into fibrils, Biochem Biophys Res Commun 270 (2000), 62-66.
    • (2000) Biochem Biophys Res Commun , vol.270 , pp. 62-66
    • Olesen, O.F.1    Dago, L.2
  • 59
    • 0035691010 scopus 로고    scopus 로고
    • Genetics of interleukin 6: Implications for Alzheimer's disease
    • A. Papassotiropoulos, C. Hock and R.M. Nitsch, Genetics of interleukin 6: implications for Alzheimer's disease, Neurobiol Aging 22 (2001), 863-871.
    • (2001) Neurobiol Aging , vol.22 , pp. 863-871
    • Papassotiropoulos, A.1    Hock, C.2    Nitsch, R.M.3
  • 60
    • 0036227542 scopus 로고    scopus 로고
    • Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study
    • R. Peila, B.L. Rodriguez and L.J. Launer, Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study, Diabetes 51 (2002), 1256-1262.
    • (2002) Diabetes , vol.51 , pp. 1256-1262
    • Peila, R.1    Rodriguez, B.L.2    Launer, L.J.3
  • 63
    • 3042641994 scopus 로고    scopus 로고
    • High-sensitivity C-reactive protein, inflammation, and cardiovascular risk: From concept to clinical practice to clinical benefit
    • P.M. Ridker, High-sensitivity C-reactive protein, inflammation, and cardiovascular risk: from concept to clinical practice to clinical benefit, Am Heart J 148 (2004), S19-26.
    • (2004) Am Heart J , vol.148
    • Ridker, P.M.1
  • 68
    • 0036167595 scopus 로고    scopus 로고
    • Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia
    • E. Tarkowski, R. Issa, M. Sjogren, A. Wallin, K. Blennow, A. Tarkowski and P. Kumar, Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia, Neurobiol Aging 23 (2002), 237-243.
    • (2002) Neurobiol Aging , vol.23 , pp. 237-243
    • Tarkowski, E.1    Issa, R.2    Sjogren, M.3    Wallin, A.4    Blennow, K.5    Tarkowski, A.6    Kumar, P.7
  • 69
    • 1342300515 scopus 로고    scopus 로고
    • Clinical use of high sensitivity C-reactive protein for the prediction of adverse cardiovascular events
    • J.L. Torres and P.M. Ridker, Clinical use of high sensitivity C-reactive protein for the prediction of adverse cardiovascular events, Curr Opin Cardiol 18 (2003), 471-478.
    • (2003) Curr Opin Cardiol , vol.18 , pp. 471-478
    • Torres, J.L.1    Ridker, P.M.2
  • 70
    • 0030979827 scopus 로고    scopus 로고
    • Relationship of C-reactive protein to risk of cardiovascular disease in the elderly. Results from the Cardiovascular Health Study and the Rural Health Promotion Project
    • R.P. Tracy, R.N. Lemaitre, B.M. Psaty, D.G. Ives, R.W. Evans, M. Cushman, E.N. Meilahn and L.H. Kuller, Relationship of C-reactive protein to risk of cardiovascular disease in the elderly. Results from the Cardiovascular Health Study and the Rural Health Promotion Project, Arterioscler Thromb Vasc Biol 17 (1997), 1121-1127.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 1121-1127
    • Tracy, R.P.1    Lemaitre, R.N.2    Psaty, B.M.3    Ives, D.G.4    Evans, R.W.5    Cushman, M.6    Meilahn, E.N.7    Kuller, L.H.8
  • 71
    • 0024355499 scopus 로고
    • Defects in insulin-receptor internalization and processing in monocytes of obese subjects and obese NIDDM patients
    • V. Trischitta, A. Brunetti, A. Chiavetta, L. Benzi, V. Papa and R. Vigneri, Defects in insulin-receptor internalization and processing in monocytes of obese subjects and obese NIDDM patients, Diabetes 38 (1989), 1579-1584.
    • (1989) Diabetes , vol.38 , pp. 1579-1584
    • Trischitta, V.1    Brunetti, A.2    Chiavetta, A.3    Benzi, L.4    Papa, V.5    Vigneri, R.6
  • 72
    • 0025129231 scopus 로고
    • Serum levels of interleukin-6 are not elevated in patients with Alzheimer's disease
    • C.M. van Duijn, A. Hofman and L. Nagelkerken, Serum levels of interleukin-6 are not elevated in patients with Alzheimer's disease, Neurosci Lett 108 (1990), 350-354.
    • (1990) Neurosci Lett , vol.108 , pp. 350-354
    • Van Duijn, C.M.1    Hofman, A.2    Nagelkerken, L.3
  • 73
    • 4043088415 scopus 로고    scopus 로고
    • The role of beta amyloid in Alzheimer's disease: Still a cause of everything or the only one who got caught?
    • G. Verdile, S. Fuller, C.S. Atwood, S.M. Laws, S.E. Gandy and R.N. Martins, The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught? Pharmacol Res 50 (2004), 397-409.
    • (2004) Pharmacol Res , vol.50 , pp. 397-409
    • Verdile, G.1    Fuller, S.2    Atwood, C.S.3    Laws, S.M.4    Gandy, S.E.5    Martins, R.N.6
  • 74
    • 0038009871 scopus 로고    scopus 로고
    • Metabolic disturbances in obesity versus sleep apnoea: The importance of visceral obesity and insulin resistance
    • A.N. Vgontzas, E.O. Bixler and G.P. Chrousos, Metabolic disturbances in obesity versus sleep apnoea: the importance of visceral obesity and insulin resistance, J Intern Med 254 (2003), 32-44.
    • (2003) J Intern Med , vol.254 , pp. 32-44
    • Vgontzas, A.N.1    Bixler, E.O.2    Chrousos, G.P.3
  • 76
    • 0037072285 scopus 로고    scopus 로고
    • Interleukin-6 and risk of cognitive decline: MacArthur studies of successful aging
    • J.D. Weaver, M.H. Huang, M. Albert, T. Harris, J.W. Rowe and T.E. Seeman, Interleukin-6 and risk of cognitive decline: MacArthur studies of successful aging. Neurology 59 (2002), 371-378.
    • (2002) Neurology , vol.59 , pp. 371-378
    • Weaver, J.D.1    Huang, M.H.2    Albert, M.3    Harris, T.4    Rowe, J.W.5    Seeman, T.E.6
  • 77
    • 0025801744 scopus 로고
    • Apolipoprotein E genotyping by one-stage PCR
    • P.R. Wenham, W.H. Price and G. Blandell, Apolipoprotein E genotyping by one-stage PCR, Lancet 337 (1991), 1158-1159.
    • (1991) Lancet , vol.337 , pp. 1158-1159
    • Wenham, P.R.1    Price, W.H.2    Blandell, G.3
  • 78
    • 0035696257 scopus 로고    scopus 로고
    • Do NSAIDs prevent Alzheimer's disease? And, if so, why? The epidemiological evidence
    • P.P. Zandi and J.C. Breitner, Do NSAIDs prevent Alzheimer's disease? And, if so, why? The epidemiological evidence, Neurobiol Aging 22 (2001), 811-817.
    • (2001) Neurobiol Aging , vol.22 , pp. 811-817
    • Zandi, P.P.1    Breitner, J.C.2
  • 79
    • 4344713918 scopus 로고    scopus 로고
    • Increased cerebrospinal fluid levels of transforming growth factor-beta1 in Alzheimer's disease
    • H. Zetterberg, N. Andreasen and K. Blennow, Increased cerebrospinal fluid levels of transforming growth factor-beta1 in Alzheimer's disease, Neurosci Lett 367 (2004), 194-196.
    • (2004) Neurosci Lett , vol.367 , pp. 194-196
    • Zetterberg, H.1    Andreasen, N.2    Blennow, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.