The preclinical phase of Alzheimer disease: A 22-year prospective study of the Framingham cohort

Archives of Neurology

Volumn 57, Issue 6, 2000, Pages 808-813

  Elias, Merrill F ^a,b   Beiser, Alexa ^d   Wolf, Philip A ^d   Au, Rhoda ^d   White, Roberta F ^c   D'Agostino, Ralph B ^a  

^a Boston University   (United States)

^b University of Maine   (United States)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; COGNITION; FEMALE; FOLLOW UP; HUMAN; LEARNING; LOGIC; LONG TERM MEMORY; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; RECALL; TASK PERFORMANCE;

EID: 0034084815     PISSN: 00039942     EISSN: None     Source Type: Journal    
DOI: 10.1001/archneur.57.6.808     Document Type: Article

References (32)

1. Bayles KA, Kaszniak AW. Communication and Cognition in normal Aging and Dementia. Boston, Mass: College-Hill Press; 1987.
2. Jacobs DM, Sano M, Dooneief G, Marder K, Bell KL, Stern Y. Neuropsychological detection and characterization ot preclinical Alzheimer's disease. Neurology. 1995;45:957-962.
3. Linn RT, Wolf PA, Bachman DL, et al. The "preclinical phase" of probable Alzheimer's disease: a 13-year prospective study of the Framingham cohort. Arch Neurol. 1995;52:485-490.
4. Almkvist O. Neuropsychological features of early Alzheimer's disease: preclinical and clinical stages. Acta Neurol Scand. 1996;93(suppl 165):63-71.
5. Masur DM, Sliwinski M, Lipton RB, Blau AD, Crystal HA. Neuropsychological prediction of dementia and the absence of dementia in healthy elderly persons. Neurology. 1994;44:1427-1432.
6. Newman SK, Warrington EK, Kennedy AM, Rossor MN. The earliest cognitive change in a person with familial Alzheimer's disease: presymptomatic neuropsychological features in a pedigree with familial Alzheimer's disease confirmed at necropsy. J Neurol Neurosurg Psychiatry. 1994;57:967-972.
7. Small BJ, Herlitz A, Fratiglioni L, Almkvist O, Bäckman L. Cognitive predictors of incident Alzheimer's disease: a prospective longitudinal study. Neuropsychology. 1997;11:413-420.
8. Fabrigoule C, Lafont S, Letenneur L, Rouch I, Dartigues JF. WAIS similarities subtest performances as predictors of dementia in elderly community residents. Brain Cogn. 1996;30:323-326.
9. Grober E, Kawas C. Learning and retention in preclinical and early Alzheimer's disease. Psychol Aging 1997;12:183-188.
10. Dartigues JF, Commenges D, Letenneur LD, et al. Cognitive predictors of dementia in elderly community residents. Neuroepitemiology. 1997;16:29-39.
11. Howieson DB, Dame A, Camicioli R, Sexton G, Payami H, Kaye JA. Cognitive markers preceding Alzheimer's dementia in the healthy oldest old. J Am Geriatr Soc. 1997;45:584-589.
12. Almkvist O, Brane G, Johanson A. Neuropsychological assessment of dementia: state of the art. Acta Neurol Scand. 1996;94(suppl 168):45-49.
13. Morris JC, McKeel DW Jr, Storandt M, et al. Very mild Alzheimer's disease: informant-based clinical, psychometric, and pathologic distinction from normal aging. Neurology. 1991;41:469-478.
14. Elias MF, Elias PK, D'Agostino RB, Silbershatz H, Wolf PA. Role of age, education, and gender on cognitive performance in the Framingham Heart Study: community-based norms. Exp Aging Res. 1997;23:201-235.
15. Farmer M, White L, Kittner S, et al. Neuropsychological test performance in Framingham: a descriptive study. Psychol Rep. 1987;60:1023-1040.
16. Wechsler D. A standardized memory scale for clinical use. J Psychol. 1945;19: 87-95.
17. Wechsler D. Manual for the Wechsler Adult Intelligence Scale. New York, NY: Psychological Corp; 1955.
18. Benton A, Hamsher KS. Multilingual Aphasia Examination. Rev ed Iowa City: University of Iowa; 1978.
19. Folstein M, Folstein SE, McHugh PR. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12:189-198.
20. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition. Washington, DC: American Psychiatric Association; 1987.
21. American Psychiatric Association. Diagnostic and Statistical Manual ot Mental Disorders, Fourth Edition. Washington, DC: American Psychiatric Association; 1994.
22. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadian EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939-944.
23. Seshadri S, Wolf PA, Beiser A, et al. Lifetime risk of dementia and Alzheimer's disease: the impact of mortality on risk estimates in the Framingham Study. Neurology. 1997;49:1498-1504.
24. Bachman DL, Wolf PA, Linn RT, et al. Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study. Neurology. 1992; 42:115-119.
25. Cox DR. Regression models and life tables. J R Stat Soc Ser B. 1972;34:187-202.
26. Hodges JR, Patterson K. Is semantic memory consistently impaired early in the course of Alzheimer's disease? neuroanatomical and diagnostic implications. Neuropsychologia. 1995;33:441-459.
27. Lezak MD. Neuropsychological Assessment. 3rd ed. New York, NY: Oxford University Press; 1995:548.
28. Kennedy A, Frackowiak R, Newman S. et al. Deficits in cerebral glucose metabolism demonstrated by positron emission tomography in individuals at risk of familial Alzheimer's disease. Neurosci Lett. 1995;186:17-20,
29. Small G, Mazziotta J, Collins M, et al. Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer's disease. JAMA. 1995;273:942-947
30. Reinman E, Caselli R, Yun L, et al. Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med. 1996;334:752-758
31. Johnson KA, Jones K, Holman BL. et al. Preclinical prediction of Alzheimer's disease using SPECT. Neurology. 1998;50:1563-1571.
32. Beach TG, Honer WG, Hughes LH. Cholinergic fiber loss associated with diffuse plaques in the non-demented elderly: the preclinical stage of Alzheimer's disease? Acta Neuropathol. 1997;93:146-153