CNS penetration of small molecules following local inflammation, widespread systemic inflammation or direct injury to the nervous system

Life Sciences

Volumn 85, Issue 11-12, 2009, Pages 450-456

  Lu, Peimin ^a   Gonzales, Cathy ^a   Chen, Yi ^a   Adedoyin, Adedayo ^a   Hummel, Michele ^a   Kennedy, Jeffrey D ^a   Whiteside, Garth T ^a  

^a PFIZER INC   (United States)

Author keywords

Atenolol; Blood brain barrier; Blood spinal cord barrier; Brain penetration; Morphine; Nerve injury; Oxycodone; Pain

Indexed keywords

ATENOLOL; CARRAGEENAN; EVANS BLUE; FREUND ADJUVANT; MORPHINE; OXYCODONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD SAMPLING; BRAIN CORTEX; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORPUS STRIATUM; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG PENETRATION; DRUG TISSUE LEVEL; ENCEPHALE ISOLE; LIQUID CHROMATOGRAPHY; LUMBAR SPINE; MALE; MEMBRANE PERMEABILITY; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE INJURY; NERVOUS SYSTEM INFLAMMATION; NERVOUS SYSTEM INJURY; NONHUMAN; RAT; SPINAL CORD SURGERY; SPINAL NERVE; TANDEM MASS SPECTROMETRY;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ARTHRITIS, EXPERIMENTAL; ATENOLOL; BRAIN CHEMISTRY; CARRAGEENAN; CENTRAL NERVOUS SYSTEM; EDEMA; FREUND'S ADJUVANT; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MIDDLE CEREBRAL ARTERY; MORPHINE; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SPINAL CORD; SPINAL NERVES;

RATTUS;

EID: 69349094004     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2009.07.009     Document Type: Article

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