Inflammatory Blockade Restores Adult Hippocampal Neurogenesis

Science

Volumn 302, Issue 5651, 2003, Pages 1760-1765

  Monje, Michelle L ^a   Toda, Hiroki ^a   Palmer, Theo D ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DRUG PRODUCTS; RADIATION;

NEUROGENESIS;

NEUROLOGY;

BACTERIUM LIPOPOLYSACCHARIDE; CYTOKINE; GAMMA INTERFERON; INDOMETACIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; NONSTEROID ANTIINFLAMMATORY AGENT; TUMOR NECROSIS FACTOR ALPHA;

COGNITION; CRANIUM; NEUROLOGY;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BRAIN RADIATION; CENTRAL NERVOUS SYSTEM; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DEMENTIA; DRUG EFFECT; FEMALE; HIPPOCAMPUS; INFLAMMATION; LEWY BODY; MICROGLIA; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIGENS, CD; APOPTOSIS; CELL DIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; CYTOKINE RECEPTOR GP130; CYTOKINES; DENTATE GYRUS; FEMALE; GAMMA RAYS; HIPPOCAMPUS; IN SITU NICK-END LABELING; INDOMETHACIN; INFLAMMATION; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MICE; MICROGLIA; MITOTIC INDEX; NEURONS; RATS; RATS, INBRED F344; RECEPTORS, INTERLEUKIN-6; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; STEM CELLS;

ANIMALIA; BACTERIA (MICROORGANISMS); HIPPOCAMPUS HIPPOCAMPUS;

EID: 0345189366     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1088417     Document Type: Article

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53. We thank T. Wyss-Coray for his gift of BV-2 microglial cells; 8. E. Hoyte for help with manuscript graphics; R. Malenka for use of the Pritzker Foundation confocal microscope; B. D. Hoehn and S. P. K. Samagh for technical assistance; and S. K. McConnell, W. C. Mobley, M. Tessier-Lavigne D. Schall, O. Mitrasinovic and P. G. Fisher for valuable insights. We would also like to thank C. Ekdahl, Z. Kokaia, and O. Lindvall and colleagues for their helpful discussion of parallel findings in models of epilepsy. Supported by grants MH20016-05 from the National Institutes of Mental Health, F30 NS04696701 from the National Institutes of Neurological Disorders and Stroke, and Palmer Lab Start up funds from the Department of Neurosurgery, Stanford University.