BMI and neuronal integrity in healthy, cognitively normal elderly: A proton magnetic resonance spectroscopy study

Obesity

Volumn 18, Issue 4, 2010, Pages 743-748

  Gazdzinski, Stefan ^a   Millin, Rachel ^a   Kaiser, Lana G ^a,b   Durazzo, Timothy C ^a,b   Mueller, Susanne G ^a,b   Weiner, Michael W ^a,b,c   Meyerhoff, Dieter J ^a,b  

^a SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CHOLINE; CREATINE; DRUG DERIVATIVE; GLUTAMIC ACID; N ACETYLASPARTIC ACID; N-ACETYLASPARTATE;

AGED; ARTICLE; BODY MASS; COGNITION; FEMALE; FRONTAL LOBE; HUMAN; MALE; METABOLISM; METHODOLOGY; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OBESITY; REFERENCE VALUE;

AGED; AGED, 80 AND OVER; ASPARTIC ACID; BODY MASS INDEX; CHOLINE; COGNITION; CREATINE; FEMALE; FRONTAL LOBE; GLUTAMIC ACID; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; OVERWEIGHT; REFERENCE VALUES;

EID: 77950189270     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2009.325     Document Type: Article

References (39)

1. Ward MA, Carlsson CM, Trivedi MA, Sager MA, Johnson SC. The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study. BMC Neurol 2005;5:23.
2. Jagust W, Harvey D, Mungas D, Haan M. Central obesity and the aging brain. Arch Neurol 2005;62:1545-1548.
3. Haltia LT, Viljanen A, Parkkola R et al. Brain white matter expansion in human obesity and the recovering effect of dieting. J Clin Endocrinol Metab 2007;92:3278-3284.
4. Pannacciulli N, Del Parigi A, Chen K et al. Brain abnormalities in human obesity: a voxel-based morphometric study. Neuroimage 2006;31: 1419-1425.
5. Volkow ND, Wang GJ, Telang F et al. Inverse association between BMI and prefrontal metabolic activity in healthy adults. Obesity (Silver Spring) 2009;17:60-65.
6. Gazdzinski S, Kornak J, Weiner MW, Meyerhoff DJ. Body mass index and magnetic resonance markers of brain integrity in adults. Ann Neurol 2008;63:652-657.
7. Ross B, Bluml S. Magnetic resonance spectroscopy of the human brain. Anat Rec 2001;265:54-84.
8. Craft S. Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment. Curr Alzheimer Res 2007;4:147-152.
9. Sahin I, Alkan A, Keskin L et al. Evaluation of in vivo cerebral metabolism on proton magnetic resonance spectroscopy in patients with impaired glucose tolerance and type 2 diabetes mellitus. J Diabetes Complicat 2008;22:254-260.
10. Elias M F, Elias PK, Sullivan LM, Wolf PA, D'Agostino RB. Obesity, diabetes and cognitive deficit: The Framingham Heart Study. Neurobiol Aging 2005;26(Suppl 1):11-16.
11. Waldstein SR, Katzel LI. Interactive relations of central versus total obesity and blood pressure to cognitive function. Int J Obes (Lond) 2006;30: 201-207.
12. Gunstad J, Paul RH, Cohen RA et al. Elevated body mass index is associated with executive dysfunction in otherwise healthy adults. Compr Psychiatry 2007;48:57-61.
13. Pignatti R, Bertella L, Albani G et al. Decision-making in obesity: a study using the Gambling Task. Eat Weight Disord 2006;11: 126-132.
14. Charlton RA, McIntyre DJ, Howe FA, Morris RG, Markus HS. The relationship between white matter brain metabolites and cognition in normal aging: the GENIE study. Brain Res 2007;1164:108-116.
15. Beydoun MA, Beydoun HA, Wang Y. Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis. Obes Rev 2008;9:204-218.
16. Gustafson D, Rothenberg E, Blennow K, Steen B, Skoog I. An 18-year follow-up of overweight and risk of Alzheimer disease. Arch Intern Med 2003;163:1524-1528.
17. Stewart R, Masaki K, Xue QL et al. A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study. Arch Neurol 2005;62:55-60.
18. Mueller SG, Stables L, Du AT et al. Measurements of hippocampal subfields and age-related changes with high resolution MRI at 4T. Neurobiol Aging 2007;28:719-726.
19. Zamboni M, Mazzali G, Zoico E et al. Health consequences of obesity in the elderly: a review of four unresolved questions. Int J Obes (Lond) 2005;29:1011-1029.
20. Jagust W, Gitcho A, Sun F et al. Brain imaging evidence of preclinical Alzheimer's disease in normal aging. Ann Neurol 2006;59:673-681.
21. Schuff N, Meyerhoff DJ, Mueller S et al. N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease. Adv Exp Med Biol 2006;576:241-62; discussion 361.
22. Bush G, Luu P, Posner MI. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci (Regul Ed) 2000;4:215-222.
23. Kalivas PW, Volkow ND. The neural basis of addiction: a pathology of motivation and choice. Am J Psychiatry 2005;162:1403-1413.
24. Kaiser LG, Schuff N, Cashdollar N, Weiner MW. Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T. Neurobiol Aging 2005;26:665-672.
25. Zahr NM, Mayer D, Pfefferbaum A, Sullivan EV. Low striatal glutamate levels underlie cognitive decline in the elderly: evidence from in vivo molecular spectroscopy. Cereb Cortex 2008;18:2241-2250.
26. Mueller SG, Stables L, Du AT et al. Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T. Neurobiol Aging 2007;28:719-726.
27. Matson GB. An integrated program for amplitude-modulated RF pulse generation and re-mapping with shaped gradients. Magn Reson Imaging 1994;12:1205-1225.
28. Tkác I, Starcuk Z, Choi I Y, Gruetter R. In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time. Magn Reson Med 1999;41:649-656.
29. Soher BJ, Vermathen P, Schuff N et al. Short TE in vivo (1)H MR spectroscopic imaging at 1.5 T: acquisition and automated spectral analysis. Magn Reson Imaging 2000;18:1159-1165.
30. Mader I, Seeger U, Karitzky J et al. Proton magnetic resonance spectroscopy with metabolite nulling reveals regional differences of macromolecules in normal human brain. J Magn Reson Imaging 2002;16:538-546.
31. Desikan RS, Ségonne F, Fischl B et al. An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage 2006;31:968-980.
32. Baslow MH. N-acetylaspartate in the vertebrate brain: metabolism and function. Neurochem Res 2003;28:941-953.
33. O'Neill J, Eberling JL, Schuff N et al. Method to correlate 1H MRSI and 18FDG-PET. Magn Reson Med 2000;43:244-250.
34. Volkow ND, Wang GJ, Telang F et al. Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing factors. Neuroimage 2008;42: 1537-1543.
35. Haltia LT, Rinne JO, Merisaari H et al. Effects of intravenous glucose on dopaminergic function in the human brain in vivo. Synapse 2007;61: 748-756.
36. Whitmer RA. The epidemiology of adiposity and dementia. Curr Alzheimer Res 2007;4:117-122.
37. Whitmer RA, Gustafson DR, Barrett-Connor E et al. Central obesity and increased risk of dementia more than three decades later. Neurology 2008;71:1057-1064.
38. Whitmer RA, Gunderson E P, Quesenberry CP Jr, Zhou J, Yaffe K. Body mass index in midlife and risk of Alzheimer disease and vascular dementia. Curr Alzheimer Res 2007;4:103-109.
39. Jernigan TL, Archibald SL, Fennema-Notestine C et al. Effects of age on tissues and regions of the cerebrum and cerebellum. Neurobiol Aging 2001;22:581-594.