-
2
-
-
0032558725
-
Leptin and the regulation of body weight in mammals
-
Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 (1998) 763-770
-
(1998)
Nature
, vol.395
, pp. 763-770
-
-
Friedman, J.M.1
Halaas, J.L.2
-
3
-
-
0033849777
-
Obesity and insulin resistance
-
Kahn B.B., and Flier J.S. Obesity and insulin resistance. J. Clin. Invest. 106 (2000) 473-481
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 473-481
-
-
Kahn, B.B.1
Flier, J.S.2
-
4
-
-
0030792590
-
A family of cytokine-inducible inhibitors of signaling
-
Starr R., et al. A family of cytokine-inducible inhibitors of signaling. Nature 387 (1997) 917-921
-
(1997)
Nature
, vol.387
, pp. 917-921
-
-
Starr, R.1
-
5
-
-
0030839112
-
A new protein containing an SH2 domain that inhibits JAK kinases
-
Endo T.A., et al. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387 (1997) 921-924
-
(1997)
Nature
, vol.387
, pp. 921-924
-
-
Endo, T.A.1
-
6
-
-
0030755934
-
Structure and function of a new STAT-induced STAT inhibitor
-
Naka T., et al. Structure and function of a new STAT-induced STAT inhibitor. Nature 387 (1997) 924-929
-
(1997)
Nature
, vol.387
, pp. 924-929
-
-
Naka, T.1
-
7
-
-
0034775824
-
The suppressors of cytokine signaling (SOCS)
-
Kile B.T., and Alexander W.S. The suppressors of cytokine signaling (SOCS). Cell. Mol. Life Sci. 58 (2001) 1627-1635
-
(2001)
Cell. Mol. Life Sci.
, vol.58
, pp. 1627-1635
-
-
Kile, B.T.1
Alexander, W.S.2
-
8
-
-
18744371050
-
SOCS1 participates in negative regulation of LPS responses
-
Nakagawa R., et al. SOCS1 participates in negative regulation of LPS responses. Immunity 17 (2002) 677-687
-
(2002)
Immunity
, vol.17
, pp. 677-687
-
-
Nakagawa, R.1
-
9
-
-
0034717062
-
SOCS3 is an insulin-induced negative regulator of insulin signaling
-
Emanuelli B., et al. SOCS3 is an insulin-induced negative regulator of insulin signaling. J. Biol. Chem. 275 (2000) 15985-15991
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 15985-15991
-
-
Emanuelli, B.1
-
10
-
-
17044451410
-
A new role for SOCS in insulin action
-
Krebs D.L., and Hilton D.J. A new role for SOCS in insulin action. Sci. STKE 169 (2003) PE6
-
(2003)
Sci. STKE
, vol.169
-
-
Krebs, D.L.1
Hilton, D.J.2
-
11
-
-
0031581086
-
Cloning and characterization of novel CIS family genes
-
Masuhara M., et al. Cloning and characterization of novel CIS family genes. Biochem. Biophys. Res. Commun. 239 (1997) 439-446
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.239
, pp. 439-446
-
-
Masuhara, M.1
-
12
-
-
20244389693
-
The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
-
Yasukawa H., et al. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 18 (1999) 1309-1320
-
(1999)
EMBO J.
, vol.18
, pp. 1309-1320
-
-
Yasukawa, H.1
-
13
-
-
0033828672
-
SOCS: physiological suppressors of cytokine signaling
-
Krebs D.L., and Hilton D.J. SOCS: physiological suppressors of cytokine signaling. J. Cell Sci. 113 (2000) 2813-2819
-
(2000)
J. Cell Sci.
, vol.113
, pp. 2813-2819
-
-
Krebs, D.L.1
Hilton, D.J.2
-
14
-
-
13044263097
-
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteosomal degradation
-
Zhang J.G., et al. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteosomal degradation. Proc. Natl. Acad. Sci. U S A. 96 (1999) 2071-2076
-
(1999)
Proc. Natl. Acad. Sci. U S A.
, vol.96
, pp. 2071-2076
-
-
Zhang, J.G.1
-
15
-
-
0030942844
-
The leptin receptor
-
Tartaglia L.A. The leptin receptor. J. Biol. Chem. 272 (1997) 6093-6096
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 6093-6096
-
-
Tartaglia, L.A.1
-
16
-
-
0032014178
-
Identification of SOCS-3 as a potential mediator of central leptin resistance
-
Bjorbaek C., et al. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell 4 (1998) 619-625
-
(1998)
Mol. Cell
, vol.4
, pp. 619-625
-
-
Bjorbaek, C.1
-
17
-
-
0033569730
-
The role of SOCS-3 in leptin signaling and leptin resistance
-
Bjorbaek C., et al. The role of SOCS-3 in leptin signaling and leptin resistance. J. Biol. Chem. 274 (1999) 30059-30065
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 30059-30065
-
-
Bjorbaek, C.1
-
18
-
-
0035162054
-
The role of leptin resistance in the lipid abnormalities of aging
-
Wang Z.W., et al. The role of leptin resistance in the lipid abnormalities of aging. FASEB J. 15 (2001) 108-114
-
(2001)
FASEB J.
, vol.15
, pp. 108-114
-
-
Wang, Z.W.1
-
19
-
-
0034649219
-
Leptin resistance in adipocytes in obesity: role of suppressors of cytokine signaling
-
Wang Z., et al. Leptin resistance in adipocytes in obesity: role of suppressors of cytokine signaling. Biochem. Biophys. Res. Commun. 277 (2000) 20-26
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.277
, pp. 20-26
-
-
Wang, Z.1
-
20
-
-
0034640508
-
Activation of downstream signals by the long form of the leptin receptor
-
Banks A.S., et al. Activation of downstream signals by the long form of the leptin receptor. J. Biol. Chem. 275 (2000) 14563-14572
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 14563-14572
-
-
Banks, A.S.1
-
21
-
-
0001421697
-
SOCS-3 mediates feedback inhibition of the leptin receptor via Tyr985
-
Bjorbak C., et al. SOCS-3 mediates feedback inhibition of the leptin receptor via Tyr985. J. Biol. Chem. 275 (2000) 40649-40657
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 40649-40657
-
-
Bjorbak, C.1
-
22
-
-
15444366416
-
Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3
-
Dunn S.L., et al. Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3. Mol. Endocrinol. 19 (2005) 925-938
-
(2005)
Mol. Endocrinol.
, vol.19
, pp. 925-938
-
-
Dunn, S.L.1
-
23
-
-
0033520389
-
SOCS-3 is essential in the regulation of fetal liver erythropoiesis
-
Marine J.-C., et al. SOCS-3 is essential in the regulation of fetal liver erythropoiesis. Cell 98 (1999) 617-627
-
(1999)
Cell
, vol.98
, pp. 617-627
-
-
Marine, J.-C.1
-
24
-
-
3142782772
-
Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
-
Howard J.K., et al. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat. Med. 10 (2004) 734-738
-
(2004)
Nat. Med.
, vol.10
, pp. 734-738
-
-
Howard, J.K.1
-
25
-
-
3142723983
-
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity
-
Mori H., et al. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat. Med. 10 (2004) 739-743
-
(2004)
Nat. Med.
, vol.10
, pp. 739-743
-
-
Mori, H.1
-
26
-
-
9244219587
-
Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
-
Munzberg H., et al. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145 (2004) 4880-4889
-
(2004)
Endocrinology
, vol.145
, pp. 4880-4889
-
-
Munzberg, H.1
-
27
-
-
33746537247
-
Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells
-
Kievit P., et al. Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. Cell Metab. 2 (2006) 123-132
-
(2006)
Cell Metab.
, vol.2
, pp. 123-132
-
-
Kievit, P.1
-
28
-
-
0034611732
-
Central nervous system control of food intake
-
Schwartz M.W., et al. Central nervous system control of food intake. Nature 404 (2000) 661-671
-
(2000)
Nature
, vol.404
, pp. 661-671
-
-
Schwartz, M.W.1
-
29
-
-
0034703229
-
Role of brain insulin receptor in control of body weight and reproduction
-
Bruning J.C., et al. Role of brain insulin receptor in control of body weight and reproduction. Science 289 (2000) 2122-2125
-
(2000)
Science
, vol.289
, pp. 2122-2125
-
-
Bruning, J.C.1
-
30
-
-
0033944152
-
Insulin activates ATP-sensitive K+ channels in hypothalamic neurones of lean, but not obese rats
-
Spanswick D., et al. Insulin activates ATP-sensitive K+ channels in hypothalamic neurones of lean, but not obese rats. Nat. Neurosci. 3 (2000) 757-758
-
(2000)
Nat. Neurosci.
, vol.3
, pp. 757-758
-
-
Spanswick, D.1
-
31
-
-
0031440266
-
Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
-
Spanswick D., et al. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390 (1997) 521-525
-
(1997)
Nature
, vol.390
, pp. 521-525
-
-
Spanswick, D.1
-
32
-
-
0034457883
-
In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin
-
Kim Y.B., et al. In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology 141 (2000) 2328-2339
-
(2000)
Endocrinology
, vol.141
, pp. 2328-2339
-
-
Kim, Y.B.1
-
33
-
-
0034874559
-
Insulin receptor substrate proteins and neuroendocrine function
-
Withers D.J. Insulin receptor substrate proteins and neuroendocrine function. Biochem. Soc. Trans. 29 (2001) 525-529
-
(2001)
Biochem. Soc. Trans.
, vol.29
, pp. 525-529
-
-
Withers, D.J.1
-
34
-
-
0027280156
-
Insulin stimulates the degradation of IRS-1 in 3T3-L1 adipocytes
-
Rice K.M., et al. Insulin stimulates the degradation of IRS-1 in 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 190 (1993) 961-967
-
(1993)
Biochem. Biophys. Res. Commun.
, vol.190
, pp. 961-967
-
-
Rice, K.M.1
-
35
-
-
0000085132
-
Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway
-
Sun X.J., et al. Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway. Diabetes 48 (1999) 1359-1364
-
(1999)
Diabetes
, vol.48
, pp. 1359-1364
-
-
Sun, X.J.1
-
36
-
-
0030061922
-
IRS-1 mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α and obesity-induced insulin resistance
-
Hotamisligil G.S., et al. IRS-1 mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α and obesity-induced insulin resistance. Science 271 (1996) 665-668
-
(1996)
Science
, vol.271
, pp. 665-668
-
-
Hotamisligil, G.S.1
-
37
-
-
0034708832
-
The c-Jun NH(2) terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser (307)
-
Aguirre V., et al. The c-Jun NH(2) terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser (307). J. Biol. Chem. 275 (2000) 9047-9054
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 9047-9054
-
-
Aguirre, V.1
-
38
-
-
0037073679
-
Serine phosphorylation of insulin receptor substrate-1 inhibitor kappa B kinase complex
-
Gao Z., et al. Serine phosphorylation of insulin receptor substrate-1 inhibitor kappa B kinase complex. J. Biol. Chem. 277 (2002) 48115-48121
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 48115-48121
-
-
Gao, Z.1
-
39
-
-
0035430280
-
Growth hormone induces cellular insulin resistance by uncoupling phosphatidylinositol 3-kinase and its downstream signals in 3T3-L1 adipocytes
-
Takano A., et al. Growth hormone induces cellular insulin resistance by uncoupling phosphatidylinositol 3-kinase and its downstream signals in 3T3-L1 adipocytes. Diabetes 50 (2001) 1891-1900
-
(2001)
Diabetes
, vol.50
, pp. 1891-1900
-
-
Takano, A.1
-
40
-
-
0030723979
-
Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk
-
Folli F., et al. Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk. J. Clin. Invest. 100 (1997) 2159-2169
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 2159-2169
-
-
Folli, F.1
-
41
-
-
4544256147
-
Suppressor of cytokine signaling-3 is a physiological regulator of adipocyte insulin signaling
-
Shi H., et al. Suppressor of cytokine signaling-3 is a physiological regulator of adipocyte insulin signaling. J. Biol. Chem. 279 (2004) 34733-34740
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 34733-34740
-
-
Shi, H.1
-
42
-
-
13444256225
-
Activation of SOCS-3 by resistin
-
Steppan C.M., et al. Activation of SOCS-3 by resistin. Mol. Cell. Biol. 25 (2005) 1569-1575
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 1569-1575
-
-
Steppan, C.M.1
-
43
-
-
0035854723
-
Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor
-
Mooney R.A., et al. Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. J. Biol. Chem. 276 (2001) 25889-25893
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 25889-25893
-
-
Mooney, R.A.1
-
44
-
-
0035930605
-
SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-α in the adipose tissue of obese mice
-
Emanuelli B., et al. SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-α in the adipose tissue of obese mice. J. Biol. Chem. 276 (2001) 47944-47949
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47944-47949
-
-
Emanuelli, B.1
-
45
-
-
2942628012
-
Suppressors of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms
-
Ueki K., et al. Suppressors of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol. Cell. Biol. 24 (2004) 5434-5446
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 5434-5446
-
-
Ueki, K.1
-
46
-
-
3142723189
-
Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse
-
Ueki K., et al. Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Proc. Natl. Acad. Sci. U S A 101 (2004) 10422-10427
-
(2004)
Proc. Natl. Acad. Sci. U S A
, vol.101
, pp. 10422-10427
-
-
Ueki, K.1
-
47
-
-
0037853260
-
Suppressors of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
-
Senn J.J., et al. Suppressors of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. J. Biol. Chem. 278 (2003) 13740-13746
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 13740-13746
-
-
Senn, J.J.1
-
48
-
-
33644782904
-
Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance
-
Shi H., et al. Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance. Diabetes 55 (2006) 699-707
-
(2006)
Diabetes
, vol.55
, pp. 699-707
-
-
Shi, H.1
-
49
-
-
0036830636
-
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
-
Rui L., et al. SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J. Biol. Chem. 277 (2002) 42394-42398
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 42394-42398
-
-
Rui, L.1
-
50
-
-
24644513922
-
Deletion of Socs7 leads to enhanced insulin action and enlarged islets of Langerhans
-
Banks A.S., et al. Deletion of Socs7 leads to enhanced insulin action and enlarged islets of Langerhans. J. Clin. Invest. 115 (2005) 2462-2471
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 2462-2471
-
-
Banks, A.S.1
-
51
-
-
0032564463
-
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
-
Starr R., et al. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Proc. Natl. Acad. Sci. U S A 95 (1998) 14395-14399
-
(1998)
Proc. Natl. Acad. Sci. U S A
, vol.95
, pp. 14395-14399
-
-
Starr, R.1
-
52
-
-
0035862334
-
Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation
-
Kawazoe Y., et al. Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation. J. Exp. Med. 193 (2001) 263-269
-
(2001)
J. Exp. Med.
, vol.193
, pp. 263-269
-
-
Kawazoe, Y.1
-
53
-
-
7244243810
-
Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3
-
Kawaguchi T., et al. Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3. Am. J. Pathol. 165 (2004) 1499-1508
-
(2004)
Am. J. Pathol.
, vol.165
, pp. 1499-1508
-
-
Kawaguchi, T.1
-
54
-
-
1842506529
-
The current biology of resistin
-
Steppan C.M., and Lazar M.A. The current biology of resistin. J. Intern. Med. 255 (2004) 439-447
-
(2004)
J. Intern. Med.
, vol.255
, pp. 439-447
-
-
Steppan, C.M.1
Lazar, M.A.2
-
55
-
-
0036275657
-
SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation
-
Krebs D.L., et al. SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. Mol. Cell. Biol. 22 (2002) 4567-4578
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 4567-4578
-
-
Krebs, D.L.1
-
56
-
-
4544287063
-
Insulin induces SOCS6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improved glucose metabolism
-
Li L., et al. Insulin induces SOCS6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improved glucose metabolism. J. Biol. Chem. 279 (2004) 34107-34114
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 34107-34114
-
-
Li, L.1
-
57
-
-
0032909703
-
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3-kinase
-
Terauchi Y., et al. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3-kinase. Nat. Genet. 21 (1999) 230-235
-
(1999)
Nat. Genet.
, vol.21
, pp. 230-235
-
-
Terauchi, Y.1
|