Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6 receptor/interleukin-6 complex

Molecular Brain Research

Volumn 55, Issue 1, 1998, Pages 35-44

  Ringheim, Garth E ^a   Szczepanik, Ann Marie ^a   Petko, Wayne ^a   Burgher, Kendra L ^a   Zhu, Sheng Zu ^b   Chao, Chun C ^b  

^a SANOFI   (France)

^b Medical Research Foundation   (United States)

Author keywords

Alzheimer's; Beta amyloid precursor protein; Interleukin 6; Soluble interleukin 6 receptor

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BASIC FIBROBLAST GROWTH FACTOR; BETA ACTIN; BRAIN PROTEIN; DNA FRAGMENT; GLYCOPROTEIN GP 130; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; LIPOPOLYSACCHARIDE; MESSENGER RNA; PHORBOL ESTER; PROTEIN PRECURSOR; RECEPTOR SUBUNIT;

ALTERNATIVE RNA SPLICING; ALZHEIMER DISEASE; ARTICLE; CELL POPULATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DNA TRANSFECTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE AMPLIFICATION; GENE INDUCTION; HUMAN; HUMAN CELL; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; ANTIGENS, CD; BASE SEQUENCE; BRAIN; CYTOKINE RECEPTOR GP130; FETAL PROTEINS; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LUCIFERASES; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; NEUROBLASTOMA; NEURONS; POLYMERASE CHAIN REACTION; RECEPTORS, INTERLEUKIN-6; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SOLUBILITY; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0032579752     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(97)00356-2     Document Type: Article

References (65)

1. Y. Akaneya, M. Takahashi, H. Hatanaka, Interleukin-1 beta enhances survival and interleukin-6 protects against MPP + neurotoxicity in cultures of fetal rat dopaminergic neurons, Exp. Neurol. 136 (1995) 44-52.
2. S.R. Barnum, J.L. Jones, U. Muller-Ladner, A. Samimi, I.L. Campbell, Chronic complement C3 gene expression in the CNS of transgenic mice with astrocyte-targeted interleukin-6 expression, Glia 18 (1996) 107-117.
3. J. Bauer, S. Strauss, U. Schreiter-Gasser, U. Ganter, P. Schlegel, I. Witt, B. Yolk, M. Berger, Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices, FEBS Lett. 285 (1991) 111-114.
4. E.N. Benveniste, S.M. Sparacio, J.G. Norris, H.E. Grenett, G.M. Fuller, Induction and regulation of interleukin-6 gene expression in rat astrocytes, J. Neuroimmunol. 30 (1990) 201-212.
5. K.C. Breen, M. Bruce, B.H. Anderton, Beta amyloid precursor protein mediates neuronal cell-cell and cell-surface adhesion, J. Neurosci. Res. 28 (1991) 90-100.
6. I.L. Campbell, C.R. Abraham, E. Masliah, P. Kembper, J.D. Inglis, M.B. Oldstone, L. Mucke, Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6, Proc. Natl. Acad. Sci. 90 (1993) 10061-10065.
7. C.C. Chao, S. Hu, F.H. Kravitz, M. Tsang, W.R. Anderson, P.K. Peterson, Transforming growth factor-β protects human neurons against β-amyloid-induced injury, Mol. Chem. Neuropathol. 23 (1994) 159-178.
8. C.C. Chao, S. Hu, W.S. Sheng, D.-F. Bu, M.I. Bukrinsky, P.K. Peterson, Cytokine-stimulated astrocytes damage human neurons via a nitric oxide mechanism, Glia 16 (1996) 276-284.
9. C.S. Chiang, A. Stalder, A. Samimi, I.L. Campbell, Reactive gliosis as a consequence of interleukin-6 expression in the brain: studies in transgenic mice, Dev. Neurosci. 16 (1994) 212-221.
10. F. de Bock, J. Dornand, G. Rondouin, Release of TNF alpha in the rat hippocampus following epileptic seizures and excitotoxic neuronal damage, Neuroreport 7 (1996) 1125-1129.
11. R. Del Bo, N. Angeretti, E. Lucca, M.G. De Simoni, G. Forloni, Reciprocal control of inflammatory cytokines, IL-1 and IL-6, and beta-amyloid production in cultures, Neurosci. Lett. 188 (1995) 70-74.
12. E. Di Santo, T. Alonzi, E. Fattori, V. Poli, G. Ciliberto, M. Sironi, P. Gnochchi, P. Ricciardi-Castagnoli, P. Ghezzi, Overexpression of interleukin-6 in the central nervous system of transgenic mice increases central but not systemic proinflammatory cytokine production, Brain Res. 740 (1996) 239-244.
13. E. Fattori, D. Lazzaro, P. Musiani, A. Modesti, T. Alonzi, G. Ciliberto, IL-6 expression in neurons of transgenic mice causes reactive astrocytosis and increase in ramified microglial cells but no neuronal damage, Eur. J. Neurosci. 7 (1995) 2441-2449.
14. K. Frei, U.V. Malipiero, T.P. Leist, R.M. Zinkernagel, M.E. Schwab, A. Fontana, On the cellular source and function of interleukin-6 produced in the central nervous system in viral disease, Eur. J. Immunol. 19 (1989) 689-694.
15. J.T. Frieling, R.W. Sauerwein, J. Wijdenes, T. Hendriks, C.J. Van der Linden, Soluble interleukin 6 receptor in biological fluids from human origin, Cytokine 6 (1994) 376-381.
16. R.A. Gadient, U. Otten, Identification of interleukin-6 (IL-6)-expressing neurons in the cerebellum and hippocampus of normal adult rats, Neurosci. Lett. 182 (1994) 243-246.
17. J. Gehrmann, R.B. Banati, M.L. Cuzner, G.W. Kreutzberg, J. Newcombe, Amyloid precursor protein (APP) expression in multiple sclerosis lesions, Glia 15 (1995) 141-151.
18. T. Hama, M. Miyamoto, H. Tsukui, C. Nishio, H. Hatanaka, Interleukin-6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats, Neurosci. Lett. 104 (1989) 340-344.
19. M.L. Heaney, D.W. Golde, Soluble cytokine receptors, Blood 87 (1996) 847-857.
20. P.C. Heinrich, J.V. Castell, T. Andus, Interleukin-6 and the acute phase response, Biochem. J. 265 (1990) 621-636.
21. T. Hirano, K. Yasukawa, H. Harada, T. Taga, Y. Watanabe, T. Matsuda, S. Kashiwamura, K. Nakajima, K. Koyama, A. Iwamatsu, S. Tsunasawa, F. Sakiyama, H. Matsui, R. Takahara, T. Taniguchi, T. Kishimoto, Complementary DNA for a novel human interleukin (BSF-2) that induces B-lymphocytes to produce immunoglobulin, Nature 324 (1986) 73-76.
22. M. Honda, S. Yamamoto, M. Cheng, K. Yasukawa, H. Suzuki, T. Saito, Y. Osugi, T. Tokunaga, T. Kishimoto, Human soluble IL-6 receptor: its detection and enhanced release by HIV infection, J. Immunol. 148 (1992) 2175-2180.
23. S. Horiuchi, Y. Koyanagi, Y. Zhou, H. Miyamoto, Y. Tanaka, M. Waki, A. Matsumoto, M. Yamamoto, N. Yamamoto, Soluble interleukin-6 receptors released from T-cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism, Eur. J. Immunol. 24 (1994) 1945-1948.
24. M. Huell, S. Strauss, B. Volk, M. Berger, J. Bauer, Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients, Acta Neuropathol. 89 (1995) 544-551.
25. K. Ikebuchi, G.G. Wong, S.C. Clark, J.N. Ihle, Y. Hirai, M. Ogawa, Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors, Proc. Natl. Acad. Sci. USA 84 (1987) 9035-9039.
26. F.G. Klier, G. Cole, W. Stallcup, D. Schubert, Amyloid β-protein precursor is associated with extracellular matrix, Brain Res. 515 (1990) 336-342.
27. J. Koistinaho, I. Pyykönen, R. Keinänen, T. Hokfelt, Expression of beta-amyloid precursor protein mRNAs following transient focal ischemia, Neuroreport 7 (1996) 2727-2731.
28. D. Korholz, P. Nussbaum, B. Pafferath, C. Mauz-Korholz, L. Hempel, S. Burdach, Activation of protein kinase C induces de novo synthesis of the soluble interleukin-6 receptor in human B-cells, Scand. J. Immunol. 40 (1994) 515-520.
29. A. Lewen, G.L. Li, P. Nilsson, Y. Olsson, L. Hillered, Traumatic brain injury in rat produces changes of beta-amyloid precursor protein immunoreactivity, Neuroreport 6 (1995) 357-360.
30. J.A. Lust, K.A. Donovan, M.P. Kline, P.R. Greipp, R.A. Kyle, N.J. Maihle, Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor, Cytokine 4 (1992) 96-100.
31. K. Lyson, S.M. McCann, The effect of interleukin-6 on pituitary hormone release in vivo and in vitro, Neuroendocrinology 54 (1991) 262-266.
32. A. Mackiewicz, H. Schooltink, P.C. Heinrich, S. Rose-John, Complex of soluble human IL-6-Receptor/IL-6 up-regulates expression of acute-phase proteins, J. Immunol. 149 (1992) 2021-2027.
33. Y. Maeda, M. Matsumoto, O. Hori, K. Kuwabara, S. Ogawa, S.D. Yan, T. Ohtsuki, T. Kinoshita, T. Kamada, D.M. Stern, Hypoxia/reoxygenation-mediated induction of astrocyte interleukin 6: A paracrine mechanism potentially enhancing neuron survival, J. Exp. Med. 180 (1994) 2297-2308.
34. M. Maes, H.Y. Meltzer, E. Bosmans, Immune-inflammatory markers in schizophrenia: comparison to normal controls and effects of clozapine, Acta Psych. Scand. 89 (1994) 346-351.
35. M. Maes, H.Y. Meltzer, E. Bosmans, R. Bergmans, E. Vandoolaeghe, R. Ranjan, R. Desnyder, Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression, J. Affective Disorders 34 (1995) 301-309.
36. S. Matsuda, T.C. Wen, F. Morita, H. Otsuka, K. Igase, H. Yoshimura, M. Sakanaka, Interleukin-6 prevents ischemia-induced learning disability and neuronal and synaptic loss in gerbils, Neurosci. Lett. 204 (1996) 109-112.
37. M. Mattson, B. Cheng, A. Culwell, F. Esch, I. Lieverburg, R. Rydel, Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein, Neuron 10 (1993) 243-254.
38. M. Minami, Y. Kuraishi, M. Satoh, Effects of kainic acid on messenger RNA levels of IL-1 beta, IL-6, TNF alpha and LIF in the rat brain, Biochem. Biophys. Res. Commun. 176 (1991) 593-598.
39. K. Mitsuyama, A. Toyonaga, E. Sasaki, O. Ishida, H. Ikeda, O. Tsuruta, K. Harada, H. Tateishi, T. Nishiyama, K. Tanikawa, Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6, Gut 36 (1995) 45-49.
40. J. Mullber, H. Schooltink, T. Stoyan, M. Gunther, L. Graeve, G. Buse, A. Mackiewicz, P.C. Heinrich, The soluble interleukin-6 receptor is generated by shedding, Eur. J. Immunol. 23 (1993) 473-480.
41. K. Murakami-Mori, T. Taga, T. Kishimoto, S. Nakamura, AIDS-associated Kaposi's Sarcoma (KS) cells express oncostatin M (OM)-specific receptor but not leukemia inhibitory factor/OM receptor or interleukin-6 receptor, J. Clin. Invest. 96 (1995) 1319-1327.
42. Y. Ohyagi, T. Tabira, Effect of growth factors and cytokines on expression of amyloid beta protein precursor mRNAs in cultured neural cells, Brain Res. Mol. Brain Res. 18 (1993) 127-132.
43. H.S. Oldenburg, M.A. Rogy, D.D. Lasarus, K.J. Van Zee, B.P. Keeler, R.A. Chizzonite, S.F. Lowry, L.L. Moldawer, Cachexia and the acute-phase response in inflammation are regulated by interleukin-6, Eur. J. Immunol. 23 (1993) 1889-1894.
44. M. Peters, S. Jacobs, M. Ehlers, P. Vollmer, J. Mullberg, E. Wolf, G. Brem, K.H. Meyer zum Buschendfelde, S. Rose-John, The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6, J. Exp. Med. 183 (1996) 1399-1406.
45. W.Q. Qiu, A. Ferreira, C. Miller, E.H. Koo, D.J. Selkoe, Cell-surface β-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner, J. Neurosci. 15 (1995) 2157-2167.
46. G.E. Ringheim, S. Aschmies, W. Petko, Additive effects of basic fibroblast growth factor and phorbol ester on β-amyloid precursor protein expression and secretion, Neurochem. Int. 30 (1996) 475-481.
47. G.E. Ringheim, K.L. Burgher, J.A. Heroux, Interleukin-6 mRNA expression by cortical neurons in culture: evidence for neuronal sources of interleukin-6 production in the brain, J. Neuroimmunol. 63 (1995) 113-123.
48. M. Sawada, A. Suzumura, T. Marunouchi, TNF-α induces IL-6 production by astrocytes but not by microglia, Brain Res. 583 (1992) 296-299.
49. T. Sato, S. Nakamura, T. Taga, T. Matsuda, T. Hirano, T. Kishimoto, Y. Kaziro, Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6, Mol. Cell. Biol. 8 (1988) 3546-3549.
50. K. Sato, K. Suyama, K. Nishida, Y. Sei, A.S. Basile, Early increases in TNF-alpha, IL-6 and IL-1 beta levels following transient cerebral ischemia in gerbil brain, Neurosci. Lett. 206 (1996) 149-152.
51. B. Schobitz, E.R. de Kloet, W. Sutanto, F. Hosboer, Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain, Eur. J. Neurosci. 5 (1993) 1426-1435.
52. B. Schobitz, G. Pezeshki, T. Pohl, U. Hemmann, P.C. Heinrich, F. Holsboer, J.M. Reul, Soluble interleukin-6 (IL-6) receptor augments central effects of IL-6 in vivo, FASEB J. 9 (1995) 659-664.
53. B. Schobitz, D.A. Voorhuis, E.R. de Kloet, Localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain, Neurosci. Lett. 136 (1992) 189-192.
54. D. Schubert, L.W. Jin, T. Saitoh, G. Cole, The regulation of amyloid beta protein precursor secretion and its modulatory role in cell adhesion, Neuron 3 (1989) 689-694.
55. A. Sluzewska, J. Rybakowski, E. Bosmans, M. Sobieska, R. Berghmans, M. Maes, K. Wiktorowicz, Indicators of immune activation in major depression, Psych. Res. 64 (1996) 161-167.
56. C. Sola, F.J. Garcia-Ladona, G. Nengod, A. Probst, P. Frey, J.M. Palacios, Increased levels of the Kunitz protease inhibitor-containing beta APP mRNAs in rat brain following neurotoxic damage, Brain Res. Mol. Brain Res. 17 (1993) 41-52.
57. 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients, Lab. Invest. 66 (1992) 223-230.
58. T. Taga, M. Hibi, Y. Hirata, K. Yamasaki, K. Yasukawa, T. Matsuda, T. Hirano, T. Kishimoto, Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130, Cell 58 (1989) 573-581.
59. V. Taupin, S. Toulmond, A. Serrano, J. Benavides, F. Zavala, Increase in IL-6, IL-1, TNF levels in rat brain following traumatic lesion. Influence of pre-and post-traumatic treatment with Ro54864, a peripheral-type (p-site) benzodiazepine ligand, J. Neuroimmunol. 42 (1993) 177-185.
60. S. Toulmond, X. Vige, D. Page, J. Benavides, Local infusion of interleukin-6 attenuates the neurotoxic effects of NMDA on rat striatal cholinergic neurons, Neurosci. Lett. 144 (1992) 49-52.
61. X. Wang, T.L. Yue, P.R. Young, F.C. Barone, G.Z. Feurerstein, Expression of interleukin-6, c-fos, and zif268 mRNAs in rat ischemic cortex, J. Cerebral Blood Flow Metab. 15 (1995) 166-171.
62. D. Watanabe, R. Yoshimura, M. Khalil, K. Yoshida, T. Kishimoto, T. Taga, H. Kiyama, Characteristic localization of gp130 (the signal-transducing receptor component used in common for IL-6/IL-11/CNTF/OSM) in the rat brain, Eur. J. Neurosci. 8 (1996) 1630-1640.
63. M.N. Woodroofe, M.L. Cuzner, Cytokine mRNA expression in inflammatory multiple sclerosis lesions: detection by non-radioactive in situ hybridization, Cytokine 5 (1993) 583-588.
64. M.N. Woodroofe, G.S. Saran, M. Wadhwa, G.M. Hayes, A.J. Loughlin, A. Tinker, M.L. Cuzner, Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production, J. Neuroimmunol. 33 (1991) 227-236.
65. M. Yamada, H. Hatanaka, Interleukin-6 protects cultured rat hippocampal neurons against glutamate-induced cell death, Brain Res. 643 (1994) 173-180.