Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing

Journal of Biological Chemistry

Volumn 288, Issue 24, 2013, Pages 17675-17688

  Çakir, Isin ^a,b   Cyr, Nicole E ^a   Perello, Mario ^a   Litvinov, Bogdan Patedakis ^a   Romero, Amparo ^a   Stuart, Ronald C ^a   Nillni, Eduardo A ^a,b  

^a BROWN UNIVERSITY   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIET-INDUCED OBESITY; ENDOPLASMIC RETICULUM STRESS; ER STRESS; NEUROPEPTIDES; PEPTIDE PRODUCTION; POST-TRANSLATIONAL PROCESSING; PRECURSOR PROTEINS; PRO-HORMONE PROCESSING;

CELL MEMBRANES; ELECTRIC RESISTANCE; ENZYMES;

NUTRITION;

ALPHA INTERMEDIN; CORTICOTROPIN; LEPTIN; MESSENGER RNA; PROOPIOMELANOCORTIN; PROPROTEIN CONVERTASE 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENERGY BALANCE; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROOPIOMELANOCORTIN GENE; PROTEIN FUNCTION; PROTEIN PROCESSING; RAT; RNA SEQUENCE;

ENDOPLASMIC RETICULUM STRESS; ENERGY METABOLISM; HYPOTHALAMUS; NEUROPEPTIDE; PROTEIN PROCESSING;

ADRENOCORTICOTROPIC HORMONE; ALPHA-MSH; ANIMALS; ARCUATE NUCLEUS; CELL LINE; DIET, HIGH-FAT; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION REGULATION; LEPTIN; MALE; MICE; OBESITY; PRO-OPIOMELANOCORTIN; PROPROTEIN CONVERTASE 2; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RATS; RATS, SPRAGUE-DAWLEY; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 84879065487     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.475343     Document Type: Article

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