Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice

Journal of Biological Chemistry

Volumn 287, Issue 27, 2012, Pages 23024-23033

  Maesako, Masato ^a   Uemura, Kengo ^a   Kubota, Masakazu ^a   Kuzuya, Akira ^a   Sasaki, Kazuki ^a   Hayashida, Naoko ^a   Asada Utsugi, Megumi ^a   Watanabe, Kiwamu ^a   Uemura, Maiko ^a   Kihara, Takeshi ^a   Takahashi, Ryosuke ^a   Shimohama, Shun ^b   Kinoshita, Ayae ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SAPPORO MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID DEPOSITION; AMYLOID PRECURSOR PROTEINS; COGNITIVE DECLINE; COGNITIVE FUNCTIONS; COMBINATION TREATMENTS; DEGRADING ENZYMES; DIETARY PATTERNS; HIGH-FAT DIET; NEPRILYSIN; TRANSGENIC MICE; TRANSGENIC MODELS;

BRAIN; GLYCOPROTEINS; MAMMALS; METABOLISM;

NUTRITION;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; FAT; MEMBRANE METALLOENDOPEPTIDASE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET RESTRICTION; DISEASE MODEL; ENZYME ACTIVITY; ENZYME DEGRADATION; EXERCISE; FEMALE; IMMUNOHISTOCHEMISTRY; INTERMETHOD COMPARISON; LIPID DIET; MALE; MAZE TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; TASK PERFORMANCE; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMAL FEED; ANIMALS; COGNITION; DIETARY FATS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; HYPERINSULINISM; MALE; MEMORY DISORDERS; METABOLIC DISEASES; MICE; MICE, TRANSGENIC; NEPRILYSIN; OBESITY; PHYSICAL CONDITIONING, ANIMAL;

MUS; MUS MUSCULUS;

EID: 84863310264     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.367011     Document Type: Article

References (35)

1. Finder, V. H. (2010) Naturally secreted oligomers of amyloid-β protein potently inhibit hippocampal long-term potentiation in vivo. J. Alzheimers Dis. 22, Suppl. 3, 5-19
2. Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., and Selkoe, D. J. (2002) Naturally secreted oligomers of amyloid-β protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535-539 (Pubitemid 34288854)
3. Lesné, S., Koh, M. T., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M., and Ashe, K. H. (2006) A specific amyloid-β protein assembly in the brain impairs memory. Nature 440, 352-357
4. Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., Regan, C. M., Walsh, D. M., Sabatini, B. L., and Selkoe, D. J. (2008) Amyloid-βprotein dimers isolated directly from Alzheimer brains impair synaptic plasticity and memory. Nat. Med. 14, 837-842
5. Luchsinger, J. A., Tang, M. X., Shea, S., and Mayeux, R. (2002) Caloric intake and the risk of Alzheimer disease. Arch. Neurol. 59, 1258-1263 (Pubitemid 34856378)
6. Ho, L., Qin, W., Pompl, P. N., Xiang, Z., Wang, J., Zhao, Z., Peng, Y., Cambareri, G., Rocher, A., Mobbs, C. V., Hof, P. R., and Pasinetti, G. M. (2004) Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer disease. FASEB J. 18, 902-904
7. Maesako, M., Uemura, K., Kubota, M., Kuzuya, A., Sasaki, K., Asada, M., Watanabe, K., Hayashida, N., Ihara, M., Ito, H., Shimohama, S., Kihara, T., and Kinoshita, A. (2012) Environmental enrichment ameliorated high fat diet-induced Aβ deposition and memory deficit in APP transgenic mice. Neurobiol. Aging 33, 1011.e11-23
8. Scarmeas, N., Stern, Y., Tang, M. X., Mayeux, R., and Luchsinger, J. A. (2006) Mediterranean diet and risk for Alzheimer disease. Ann. Neurol. 59, 912-921 (Pubitemid 43830923)
9. Laurin, D., Verreault, R., Lindsay, J., MacPherson, K., and Rockwood, K. (2001) Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol. 58, 498-504 (Pubitemid 32217469)
10. 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J. Neurosci. 20, 4050-4058
11. Maesako, M., Uemura, K., Kuzuya, A., Sasaki, K., Asada, M., Watanabe, K., Ando, K., Kubota, M., Kihara, T., and Kinoshita, A. (2011) Presenilin regulates insulin signaling via a γ-secretase-independent mechanism. J. Biol. Chem. 286, 25309-25316
12. Kitaguchi, H., Tomimoto, H., Ihara, M., Shibata, M., Uemura, K., Kalaria, R. N., Kihara, T., Asada-Utsugi, M., Kinoshita, A., and Takahashi, R. (2009) Chronic cerebral hypoperfusion accelerates amyloid-β deposition in APPSwInd transgenic mice. Brain res. 1294, 202-210
13. Rose, J. B., Crews, L., Rockenstein, E., Adame, A., Mante, M., Hersh, L. B., Gage, F. H., Spencer, B., Potkar, R., Marr, R. A., and Masliah, E. (2009) Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer disease. J. Neurosci. 29, 1115-1125
14. 1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nat. Med 6, 143-150
15. Shirotani, K., Tsubuki, S., Iwata, N., Takaki, Y., Harigaya, W., Maruyama, K., Kiryu-Seo, S., Kiyama, H., Iwata, H., Tomita, T., Iwatsubo, T., and Saido, T. C. (2001) Neprilysin degrades both amyloid-β peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon- sensitive endopeptidases. J. Biol. Chem. 276, 21895-21901
16. Solfrizzi, V., Panza, F., and Capurso, A. (2003) The role of diet in cognitive decline. J. Neural. Transm. 110, 95-110 (Pubitemid 36135557)
17. Panza, F., Capurso, C., D'Introno, A., Colacicco, A. M., Del Parigi, A., Seripa, D., Pilotto, A., Capurso, A., and Solfrizzi, V. (2006) Diet, cholesterol metabolism, and Alzheimer disease: apolipoprotein E as a possible link? J. Am Geriatr Soc. 54, 1963-1965 (Pubitemid 44915861)
18. Scarmeas, N., Luchsinger, J. A., Mayeux, R., and Stern, Y. (2007) Mediterranean diet and Alzheimer disease mortality. Neurology 69, 1084-1093 (Pubitemid 47517553)
19. Kivipelto, M., Ngandu, T., Fratiglioni, L., Viitanen, M., Kåreholt, I., Winblad, B., Helkala, E. L., Tuomilehto, J., Soininen, H., and Nissinen, A. (2005) Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch Neurol. 62, 1556-1560 (Pubitemid 41434560)
20. Whitmer, R. A., Gunderson, E. P., Quesenberry, C. P., Jr., Zhou, J., and Yaffe, K. (2007) Body mass index in midlife and risk of Alzheimer disease and vascular dementia. Curr. Alzheimer Res. 4, 103-109 (Pubitemid 46557496)
21. Fitzpatrick, A. L., Kuller, L. H., Lopez, O. L., Diehr, P., O'Meara, E. S., Longstreth, W. T., Jr., and Luchsinger, J. A. (2009) Midlife and late-life obesity and the risk of dementia: cardiovascular health study. Arch Neurol. 66, 336-342
22. Ho, A. J., Raji, C. A., Becker, J. T., Lopez, O. L., Kuller, L. H., Hua, X., Lee, S., Hibar, D., Dinov, I. D., Stein, J. L., Jack, C. R., Jr., Weiner, M. W., Toga, A. W., and Thompson, P. M. (2010) Obesity is linked with lower brain volume in 700 AD and MCI patients. Neurobiol. Aging 31, 1326-1339
23. Watson, G. S., Cholerton, B. A., Reger, M. A., Baker, L. D., Plymate, S. R., Asthana, S., Fishel, M. A., Kulstad, J. J., Green, P. S., Cook, D. G., Kahn, S. E., Keeling, M. L., and Craft, S. (2005) Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study. Am. J. Geriatr Psychiatry 13, 950-958 (Pubitemid 46638661)
24. Pedersen, W. A., McMillan, P. J., Kulstad, J. J., Leverenz, J. B., Craft, S., and Haynatzki, G. R. (2006) Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice. Exp. Neurol. 199, 265-273 (Pubitemid 43928978)
25. Reger, M. A., Watson, G. S., Green, P. S., Wilkinson, C. W., Baker, L. D., Cholerton, B., Fishel, M. A., Plymate, S. R., Breitner, J. C., DeGroodt, W., Mehta, P., and Craft, S. (2008) Intranasal insulin improves cognition and modulates β-amyloid in early AD. Neurology 70, 440-448
26. Shepardson, N. E., Shankar, G. M., and Selkoe, D. J. (2011) Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies. Arch Neurol. 68, 1239-1244
27. Magkos, F., Yannakoulia, M., Chan, J. L., and Mantzoros, C. S. (2009) Management of the metabolic syndrome and type 2 diabetes through lifestyle modification. Annu Rev. Nutr 29, 223-256
28. Hu, Y. S., Xu, P., Pigino, G., Brady, S. T., Larson, J., and Lazarov, O. (2010) Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer disease-linked APPswe/PS1ΔE9 mice. FASEB J. 24, 1667-1681
29. Neeper, S. A., Gómez-Pinilla, F., Choi, J., and Cotman, C. (1995) Exercise and brain neurotrophins. Nature 373, 109
30. Tucker, A. M., and Stern, Y. (2011) Cognitive reserve in aging. Curr Alzheimer Res. 8, 354-360
31. Lazarov, O., Robinson, J., Tang, Y. P., Hairston, I. S., Korade-Mirnics, Z., Lee, V. M., Hersh, L. B., Sapolsky, R. M., Mirnics, K., and Sisodia, S. S. (2005) Environmental enrichment reduces Aβ levels and amyloid deposition in transgenic mice. Cell 120, 701-713 (Pubitemid 40343081)
32. Thirumangalakudi, L., Prakasam, A., Zhang, R., Bimonte-Nelson, H., Sambamurti, K., Kindy, M. S., and Bhat, N. R. (2008) High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. J. Neurochem. 106, 475-485 (Pubitemid 351840227)
33. Fukumoto, H., Cheung, B. S., Hyman, B. T., and Irizarry, M. C. (2002) β-Secretase protein and activity are increased in the neocortex in Alzheimer disease. Arch Neurol. 59, 1381-1389 (Pubitemid 35014802)
34. Yang, L. B., Lindholm, K., Yan, R., Citron, M., Xia, W., Yang, X. L., Beach, T., Sue, L., Wong, P., Price, D., Li, R., and Shen, Y. (2003) Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. Nat. Med. 9, 3-4 (Pubitemid 36098241)
35. Li, R., Lindholm, K., Yang, L. B., Yue, X., Citron, M., Yan, R., Beach, T., Sue, L., Sabbagh, M., Cai, H., Wong, P., Price, D., and Shen, Y. (2004) Amyloid-β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer disease patients. Proc. Natl. Acad. Sci. U.S.A. 101, 3632-3637 (Pubitemid 38338246)