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Volumn 31, Issue 9, 2010, Pages 1516-1531

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

Author keywords

Amyloid beta; Cofilin; Dietary fat; Docosahexaenoic acid; Drebrin; GFAP; LR11; PAK; Polyunsaturated fatty acid; Synaptophysin; Tau

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; DETERGENT; DREBRIN; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; SYNAPTOPHYSIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNTAXIN; SYNTAXIN 3; TAU PROTEIN; UNCLASSIFIED DRUG;

EID: 77954955083     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2008.08.022     Document Type: Article
Times cited : (229)

References (83)
  • 1
    • 0026740795 scopus 로고
    • Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
    • Arriagada P.V., Growdon J.H., Hedley-Whyte E.T., Hyman B.T. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 1992, 42:631-639.
    • (1992) Neurology , vol.42 , pp. 631-639
    • Arriagada, P.V.1    Growdon, J.H.2    Hedley-Whyte, E.T.3    Hyman, B.T.4
  • 2
    • 34548036227 scopus 로고    scopus 로고
    • Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
    • Ballatore C., Lee V.M., Trojanowski J.Q. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat. Rev. Neurosci. 2007, 8:663-672.
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 663-672
    • Ballatore, C.1    Lee, V.M.2    Trojanowski, J.Q.3
  • 3
    • 1542268242 scopus 로고    scopus 로고
    • Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function
    • Bennett D.A., Schneider J.A., Wilson R.S., Bienias J.L., Arnold S.E. Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function. Arch. Neurol. 2004, 61:378-384.
    • (2004) Arch. Neurol. , vol.61 , pp. 378-384
    • Bennett, D.A.1    Schneider, J.A.2    Wilson, R.S.3    Bienias, J.L.4    Arnold, S.E.5
  • 7
    • 36649010031 scopus 로고    scopus 로고
    • Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies
    • Calon F., Cole G. Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies. Prostaglandins Leukot. Essent. Fatty Acids 2007, 77:287-293.
    • (2007) Prostaglandins Leukot. Essent. Fatty Acids , vol.77 , pp. 287-293
    • Calon, F.1    Cole, G.2
  • 8
    • 23944503308 scopus 로고    scopus 로고
    • Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease
    • Calon F., Lim G.P., Morihara T., Yang F., Ubeda O., Salem N., Frautschy S.A., Cole G.M. Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease. Eur. J. Neurosci. 2005, 22:617-626.
    • (2005) Eur. J. Neurosci. , vol.22 , pp. 617-626
    • Calon, F.1    Lim, G.P.2    Morihara, T.3    Yang, F.4    Ubeda, O.5    Salem, N.6    Frautschy, S.A.7    Cole, G.M.8
  • 11
    • 0032571154 scopus 로고    scopus 로고
    • Abnormal content of n-6 and n-3 long-chain unsaturated fatty acids in the phosphoglycerides and cholesterol esters of parahippocampal cortex from Alzheimer's disease patients and its relationship to acetyl CoA content
    • Corrigan F.M., Horrobin D.F., Skinner E.R., Besson J.A., Cooper M.B. Abnormal content of n-6 and n-3 long-chain unsaturated fatty acids in the phosphoglycerides and cholesterol esters of parahippocampal cortex from Alzheimer's disease patients and its relationship to acetyl CoA content. Int. J. Biochem. Cell. Biol. 1998, 30:197-207.
    • (1998) Int. J. Biochem. Cell. Biol. , vol.30 , pp. 197-207
    • Corrigan, F.M.1    Horrobin, D.F.2    Skinner, E.R.3    Besson, J.A.4    Cooper, M.B.5
  • 12
    • 33746752209 scopus 로고    scopus 로고
    • Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment
    • Counts S.E., Nadeem M., Lad S.P., Wuu J., Mufson E.J. Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment. J. Neuropathol. Exp. Neurol. 2006, 65:592-601.
    • (2006) J. Neuropathol. Exp. Neurol. , vol.65 , pp. 592-601
    • Counts, S.E.1    Nadeem, M.2    Lad, S.P.3    Wuu, J.4    Mufson, E.J.5
  • 15
    • 47849121436 scopus 로고    scopus 로고
    • An integrated and unifying hypothesis for the metabolic basis of sporadic Alzheimer's disease
    • Erol A. An integrated and unifying hypothesis for the metabolic basis of sporadic Alzheimer's disease. J. Alzheimers Dis. 2008, 13:241-253.
    • (2008) J. Alzheimers Dis. , vol.13 , pp. 241-253
    • Erol, A.1
  • 16
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • Folch J., Lees M., Stanley G.H.S. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 1957, 226:497-509.
    • (1957) J. Biol. Chem. , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Stanley, G.H.S.3
  • 22
    • 34247380762 scopus 로고    scopus 로고
    • Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels
    • Green K.N., Martinez-Coria H., Khashwji H., Hall E.B., Yurko-Mauro K.A., Ellis L., LaFerla F.M. Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. J. Neurosci. 2007, 27:4385-4395.
    • (2007) J. Neurosci. , vol.27 , pp. 4385-4395
    • Green, K.N.1    Martinez-Coria, H.2    Khashwji, H.3    Hall, E.B.4    Yurko-Mauro, K.A.5    Ellis, L.6    LaFerla, F.M.7
  • 23
    • 33947264635 scopus 로고    scopus 로고
    • Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease
    • Halagappa V.K.M., Guo Z., Pearson M., Matsuoka Y., Cutler R.G., LaFerla F.M., Mattson M.P. Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease. Neurobiol. Dis. 2007, 26:212-220.
    • (2007) Neurobiol. Dis. , vol.26 , pp. 212-220
    • Halagappa, V.K.M.1    Guo, Z.2    Pearson, M.3    Matsuoka, Y.4    Cutler, R.G.5    LaFerla, F.M.6    Mattson, M.P.7
  • 24
    • 0030025216 scopus 로고    scopus 로고
    • Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease
    • Harigaya Y., Shoji M., Shirao T., Hirai S. Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease. J. Neurosci. Res. 1996, 43:87-92.
    • (1996) J. Neurosci. Res. , vol.43 , pp. 87-92
    • Harigaya, Y.1    Shoji, M.2    Shirao, T.3    Hirai, S.4
  • 25
    • 0033033642 scopus 로고    scopus 로고
    • Loss of proteins regulating synaptic plasticity in normal aging of the human brain and in Alzheimer disease
    • Hatanpää K., Isaacs K.R., Shirao T., Brady D.R., Rapoport S.I. Loss of proteins regulating synaptic plasticity in normal aging of the human brain and in Alzheimer disease. J. Neuropathol. Exp. Neurol. 1999, 58:637-643.
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 637-643
    • Hatanpää, K.1    Isaacs, K.R.2    Shirao, T.3    Brady, D.R.4    Rapoport, S.I.5
  • 26
    • 0033562792 scopus 로고    scopus 로고
    • Change in the shape of dendritic spines caused by overexpression of drebrin in cultured cortical neurons
    • Hayashi K., Shirao T. Change in the shape of dendritic spines caused by overexpression of drebrin in cultured cortical neurons. J. Neurosci. 1999, 19:3918-3925.
    • (1999) J. Neurosci. , vol.19 , pp. 3918-3925
    • Hayashi, K.1    Shirao, T.2
  • 27
    • 33745780575 scopus 로고    scopus 로고
    • Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease
    • Heredia L., Helguera P., de Olmos S., Kedikian G., Solá Vigo F., LaFerla F., Staufenbiel M., de Olmos J., Busciglio J., Cáceres A., Lorenzo A. Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease. J. Neurosci. 2006, 26:6533-6542.
    • (2006) J. Neurosci. , vol.26 , pp. 6533-6542
    • Heredia, L.1    Helguera, P.2    de Olmos, S.3    Kedikian, G.4    Solá Vigo, F.5    LaFerla, F.6    Staufenbiel, M.7    de Olmos, J.8    Busciglio, J.9    Cáceres, A.10    Lorenzo, A.11
  • 31
    • 0031004604 scopus 로고    scopus 로고
    • Evidence for the involvement of docosahexaenoic acid in cholinergic stimulated signal transduction at the synapse
    • Jones C.R., Arai T., Rapoport S.I. Evidence for the involvement of docosahexaenoic acid in cholinergic stimulated signal transduction at the synapse. Neurochem. Res. 1997, 22:663-670.
    • (1997) Neurochem. Res. , vol.22 , pp. 663-670
    • Jones, C.R.1    Arai, T.2    Rapoport, S.I.3
  • 35
    • 25644456097 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease
    • Kitazawa M., Oddo S., Yamasaki T.R., Green K.N., LaFerla F.M. Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J. Neurosci. 2005, 25:8843-8853.
    • (2005) J. Neurosci. , vol.25 , pp. 8843-8853
    • Kitazawa, M.1    Oddo, S.2    Yamasaki, T.R.3    Green, K.N.4    LaFerla, F.M.5
  • 36
    • 50249086898 scopus 로고    scopus 로고
    • Targets of caspase-6 activity in human neurons and Alzheimer disease
    • Klaiman G., Petzke T.L., Hammond J., Leblanc A.C. Targets of caspase-6 activity in human neurons and Alzheimer disease. Mol. Cell Proteomics 2008, 7:1541-1555.
    • (2008) Mol. Cell Proteomics , vol.7 , pp. 1541-1555
    • Klaiman, G.1    Petzke, T.L.2    Hammond, J.3    Leblanc, A.C.4
  • 39
    • 0022548964 scopus 로고
    • Direct transesterification of all classes of lipids in a one-step reaction
    • Lepage G., Roy C.C. Direct transesterification of all classes of lipids in a one-step reaction. J. Lipid. Res. 1986, 27:114-120.
    • (1986) J. Lipid. Res. , vol.27 , pp. 114-120
    • Lepage, G.1    Roy, C.C.2
  • 40
    • 0345275964 scopus 로고    scopus 로고
    • Association of aortic atherosclerosis with cerebral beta-amyloidosis and learning deficits in a mouse model of Alzheimer's disease
    • Li L., Cao D., Garber D.W., Kim H., Fukuchi K. Association of aortic atherosclerosis with cerebral beta-amyloidosis and learning deficits in a mouse model of Alzheimer's disease. Am. J. Pathol. 2003, 163:2155-2164.
    • (2003) Am. J. Pathol. , vol.163 , pp. 2155-2164
    • Li, L.1    Cao, D.2    Garber, D.W.3    Kim, H.4    Fukuchi, K.5
  • 41
    • 16244416174 scopus 로고    scopus 로고
    • A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model
    • Lim G.P., Calon F., Morihara T., Yang F., Teter B., Ubeda O., Salem N., Frautschy S.A., Cole G.M. A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J. Neurosci. 2005, 25:3032-3040.
    • (2005) J. Neurosci. , vol.25 , pp. 3032-3040
    • Lim, G.P.1    Calon, F.2    Morihara, T.3    Yang, F.4    Teter, B.5    Ubeda, O.6    Salem, N.7    Frautschy, S.A.8    Cole, G.M.9
  • 42
    • 0035503597 scopus 로고    scopus 로고
    • The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    • Lim G.P., Chu T., Yang F., Beech W., Frautschy S.A., Cole G.M. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J. Neurosci. 2001, 21:8370-8377.
    • (2001) J. Neurosci. , vol.21 , pp. 8370-8377
    • Lim, G.P.1    Chu, T.2    Yang, F.3    Beech, W.4    Frautschy, S.A.5    Cole, G.M.6
  • 45
    • 0036334166 scopus 로고    scopus 로고
    • Caloric intake and the risk of Alzheimer disease
    • Luchsinger J.A., Tang M., Shea S., Mayeux R. Caloric intake and the risk of Alzheimer disease. Arch. Neurol. 2002, 59:1258-1263.
    • (2002) Arch. Neurol. , vol.59 , pp. 1258-1263
    • Luchsinger, J.A.1    Tang, M.2    Shea, S.3    Mayeux, R.4
  • 47
    • 37549040611 scopus 로고    scopus 로고
    • Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer's disease (AD): relevance to AD prevention
    • Ma Q.L., Teter B., Ubeda O.J., Morihara T., Dhoot D., Nyby M.D., Tuck M.L., Frautschy S.A., Cole G.M. Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer's disease (AD): relevance to AD prevention. J. Neurosci. 2007, 27:14299-14307.
    • (2007) J. Neurosci. , vol.27 , pp. 14299-14307
    • Ma, Q.L.1    Teter, B.2    Ubeda, O.J.3    Morihara, T.4    Dhoot, D.5    Nyby, M.D.6    Tuck, M.L.7    Frautschy, S.A.8    Cole, G.M.9
  • 48
    • 3943092621 scopus 로고    scopus 로고
    • Pathways towards and away from Alzheimer's disease
    • Mattson M.P. Pathways towards and away from Alzheimer's disease. Nature 2004, 430:631-639.
    • (2004) Nature , vol.430 , pp. 631-639
    • Mattson, M.P.1
  • 49
    • 33646126924 scopus 로고    scopus 로고
    • A decade of modeling Alzheimer's disease in transgenic mice
    • McGowan E., Eriksen J., Hutton M. A decade of modeling Alzheimer's disease in transgenic mice. Trends Genet. 2006, 22:281-289.
    • (2006) Trends Genet. , vol.22 , pp. 281-289
    • McGowan, E.1    Eriksen, J.2    Hutton, M.3
  • 53
    • 0038117796 scopus 로고    scopus 로고
    • Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
    • Näslund J., Haroutunian V., Mohs R., Davis K.L., Davies P., Greengard P., Buxbaum J.D. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA 2000, 283:1571-1577.
    • (2000) JAMA , vol.283 , pp. 1571-1577
    • Näslund, J.1    Haroutunian, V.2    Mohs, R.3    Davis, K.L.4    Davies, P.5    Greengard, P.6    Buxbaum, J.D.7
  • 54
    • 38449120482 scopus 로고    scopus 로고
    • Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664
    • Nguyen T.V., Galvan V., Huang W., Banwait S., Tang H., Zhang J., Bredesen D.E. Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664. J. Neurochem. 2008, 104:1065-1080.
    • (2008) J. Neurochem. , vol.104 , pp. 1065-1080
    • Nguyen, T.V.1    Galvan, V.2    Huang, W.3    Banwait, S.4    Tang, H.5    Zhang, J.6    Bredesen, D.E.7
  • 55
    • 0344845132 scopus 로고    scopus 로고
    • Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
    • Oddo S., Caccamo A., Kitazawa M., Tseng B.P., LaFerla F.M. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol. Aging. 2003, 24:1063-1070.
    • (2003) Neurobiol. Aging. , vol.24 , pp. 1063-1070
    • Oddo, S.1    Caccamo, A.2    Kitazawa, M.3    Tseng, B.P.4    LaFerla, F.M.5
  • 57
    • 32544435097 scopus 로고    scopus 로고
    • The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments
    • Offe K., Dodson S.E., Shoemaker J.T., Fritz J.J., Gearing M., Levey A.I., Lah J.J. The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments. J. Neurosci. 2006, 26:1596-1603.
    • (2006) J. Neurosci. , vol.26 , pp. 1596-1603
    • Offe, K.1    Dodson, S.E.2    Shoemaker, J.T.3    Fritz, J.J.4    Gearing, M.5    Levey, A.I.6    Lah, J.J.7
  • 58
    • 33747180133 scopus 로고    scopus 로고
    • Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice
    • Oksman M., Iivonen H., Hogyes E., Amtul Z., Penke B., Leenders I., Broersen L., Lutjohann D., Hartmann T., Tanila H. Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice. Neurobiol. Dis. 2006, 23:563-572.
    • (2006) Neurobiol. Dis. , vol.23 , pp. 563-572
    • Oksman, M.1    Iivonen, H.2    Hogyes, E.3    Amtul, Z.4    Penke, B.5    Leenders, I.6    Broersen, L.7    Lutjohann, D.8    Hartmann, T.9    Tanila, H.10
  • 59
    • 20444373701 scopus 로고    scopus 로고
    • Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of Alzheimer disease and identification of lipoxidation targets
    • Pamplona R., Dalfó E., Ayala V., Bellmunt M.J., Prat J., Ferrer I., Portero-Otín M. Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of Alzheimer disease and identification of lipoxidation targets. J. Biol. Chem. 2005, 280:21522-21530.
    • (2005) J. Biol. Chem. , vol.280 , pp. 21522-21530
    • Pamplona, R.1    Dalfó, E.2    Ayala, V.3    Bellmunt, M.J.4    Prat, J.5    Ferrer, I.6    Portero-Otín, M.7
  • 61
    • 35948967252 scopus 로고    scopus 로고
    • Dietary influences on cognitive function with aging: from high-fat diets to healthful eating
    • Parrott M.D., Greenwood C.E. Dietary influences on cognitive function with aging: from high-fat diets to healthful eating. Ann. N. Y. Acad. Sci. 2007, 1114:389-397.
    • (2007) Ann. N. Y. Acad. Sci. , vol.1114 , pp. 389-397
    • Parrott, M.D.1    Greenwood, C.E.2
  • 63
    • 33846098121 scopus 로고    scopus 로고
    • Recent advances in the supply of docosahexaenoate to the nervous system
    • Humana Press, Totowa, NJ, D. Mostofsky, S. Yehuda, N. Salem (Eds.)
    • Pawlosky R.J.J., Salem N. Recent advances in the supply of docosahexaenoate to the nervous system. Fatty Acids: From Neuronal Membrane to Physiological and Behavioral Function 2001, 115-123. Humana Press, Totowa, NJ. D. Mostofsky, S. Yehuda, N. Salem (Eds.).
    • (2001) Fatty Acids: From Neuronal Membrane to Physiological and Behavioral Function , pp. 115-123
    • Pawlosky, R.J.J.1    Salem, N.2
  • 67
    • 36749082536 scopus 로고    scopus 로고
    • Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver
    • Rapoport S.I., Rao J.S., Igarashi M. Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver. Prostaglandins Leukot. Essent. Fatty Acids. 2007, 77:251-261.
    • (2007) Prostaglandins Leukot. Essent. Fatty Acids. , vol.77 , pp. 251-261
    • Rapoport, S.I.1    Rao, J.S.2    Igarashi, M.3
  • 73
    • 34547488455 scopus 로고    scopus 로고
    • Role of actin cytoskeleton in dendritic spine morphogenesis
    • Sekino Y., Kojima N., Shirao T. Role of actin cytoskeleton in dendritic spine morphogenesis. Neurochem. Int. 2007, 51:92-104.
    • (2007) Neurochem. Int. , vol.51 , pp. 92-104
    • Sekino, Y.1    Kojima, N.2    Shirao, T.3
  • 74
    • 0037166050 scopus 로고    scopus 로고
    • Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome
    • Shim K.S., Lubec G. Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome. Neurosci. Lett. 2002, 324:209-212.
    • (2002) Neurosci. Lett. , vol.324 , pp. 209-212
    • Shim, K.S.1    Lubec, G.2
  • 75
    • 0027163166 scopus 로고
    • Differences in the fatty acid composition of the grey and white matter of different regions of the brains of patients with Alzheimer's disease and control subjects
    • Skinner E.R., Watt C., Besson J.A., Best P.V. Differences in the fatty acid composition of the grey and white matter of different regions of the brains of patients with Alzheimer's disease and control subjects. Brain 1993, 116(Pt 3):717-725.
    • (1993) Brain , vol.116 , Issue.PART 3 , pp. 717-725
    • Skinner, E.R.1    Watt, C.2    Besson, J.A.3    Best, P.V.4
  • 76
    • 0025913434 scopus 로고
    • Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease
    • Söderberg M., Edlund C., Kristensson K., Dallner G. Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease. Lipids 1991, 26:421-425.
    • (1991) Lipids , vol.26 , pp. 421-425
    • Söderberg, M.1    Edlund, C.2    Kristensson, K.3    Dallner, G.4
  • 78
    • 38049018185 scopus 로고    scopus 로고
    • Biochemical characterization of abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease
    • Tremblay C., Pilote M., Phivilay A., Emond V., Bennett D.A., Calon F. Biochemical characterization of abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease. J. Alzheimers. Dis. 2007, 12:377-390.
    • (2007) J. Alzheimers. Dis. , vol.12 , pp. 377-390
    • Tremblay, C.1    Pilote, M.2    Phivilay, A.3    Emond, V.4    Bennett, D.A.5    Calon, F.6
  • 79
    • 77950530068 scopus 로고    scopus 로고
    • Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease
    • in press, published on-line on July 28, 2008; doi:10.1016/j.neurobiolaging.2008.06.011
    • Wirths, O., Breyhan, H., Marcello, A., Cotel, M.C., Brück, W., Bayer, T.A. Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease. Neurobiol. Aging, in press, published on-line on July 28, 2008; doi:10.1016/j.neurobiolaging.2008.06.011.
    • Neurobiol. Aging
    • Wirths, O.1    Breyhan, H.2    Marcello, A.3    Cotel, M.C.4    Brück, W.5    Bayer, T.A.6
  • 80
    • 33748471099 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease: driving force, bystander or beneficial response?
    • Wyss-Coray T. Inflammation in Alzheimer disease: driving force, bystander or beneficial response?. Nat. Med. 2006, 12:1005-1015.
    • (2006) Nat. Med. , vol.12 , pp. 1005-1015
    • Wyss-Coray, T.1
  • 81
    • 0034744296 scopus 로고    scopus 로고
    • TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice
    • Wyss-Coray T., Lin C., Yan F., Yu G.Q., Rohde M., McConlogue L., Masliah E., Mucke L. TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Nat. Med. 2001, 7:612-618.
    • (2001) Nat. Med. , vol.7 , pp. 612-618
    • Wyss-Coray, T.1    Lin, C.2    Yan, F.3    Yu, G.Q.4    Rohde, M.5    McConlogue, L.6    Masliah, E.7    Mucke, L.8
  • 82
    • 58149465620 scopus 로고    scopus 로고
    • Reduced membrane lipids in the cortex of Alzheimer's disease transgenic mice
    • in press, published on-line on March 2, 2008; doi:10.1007/s11064-008-9673-1
    • Yao, J.K., Wengenack, T.M., Curran, G.L., Poduslo, J.F. Reduced membrane lipids in the cortex of Alzheimer's disease transgenic mice. Neurochem. Res. in press, published on-line on March 29, 2008; doi:10.1007/s11064-008-9673-1.
    • Neurochem. Res.
    • Yao, J.K.1    Wengenack, T.M.2    Curran, G.L.3    Poduslo, J.F.4


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