High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice

Journal of Neurochemistry

Volumn 106, Issue 1, 2008, Pages 475-485

  Thirumangalakudi, Lakshmi ^a   Prakasam, Annamalai ^a   Zhang, Ran ^a   Bimonte Nelson, Heather ^b   Sambamurti, Kumar ^a   Kindy, Mark S ^a   Bhat, Narayan R ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Amyloid precursor protein processing; Beta site APP cleaving enzyme 1; Cholesterol; Low density lipoprotein receptor; Neuroinflammation; Working memory

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CHOLESTEROL; CYCLOOXYGENASE 2; CYTOKINE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; C57BL 6 MOUSE; CHOLESTEROL DIET; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; CYTOKINE RELEASE; ENCEPHALITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEEDING; HIPPOCAMPUS; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; IMMUNOHISTOCHEMISTRY; LIPID DIET; MAZE TEST; MICROGLIA; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; TRANSGENIC MOUSE; WILD TYPE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BRAIN; CHOLESTEROL; CYTOKINES; DIETARY FATS; DISEASE MODELS, ANIMAL; ENCEPHALITIS; HYPERCHOLESTEROLEMIA; MAZE LEARNING; MEMORY DISORDERS; MEMORY, SHORT-TERM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; PEPTIDE FRAGMENTS; RECEPTORS, LDL; UP-REGULATION;

MUS; MUS MUSCULUS; RODENTIA;

EID: 45249117903     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05415.x     Document Type: Article

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