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Volumn 5, Issue OCT, 2014, Pages

Targeting p110gamma in gastrointestinal cancers: Attack on multiple fronts

Author keywords

Angiogenesis; Cancer; HCC; Inflammation; Metastasis; P110 ; PDAC; Phosphoinositide 3 kinase

Indexed keywords

2 (6 AMINO 9 PURINYLMETHYL) 5 METHYL 3 (2 METHYLPHENYL) 3H QUINAZOLIN 4 ONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 5 [5 (4 FLUORO 2 HYDROXYPHENYL)FURFURYLIDENE] 2,4 THIAZOLIDINEDIONE; DUVELISIB; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOINOSITIDE 3 KINASE CATALYTIC SUBUNIT P110GAMMA; UNCLASSIFIED DRUG;

EID: 84908376802     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2014.00391     Document Type: Review
Times cited : (10)

References (113)
  • 1
    • 84903188335 scopus 로고    scopus 로고
    • Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer
    • Ali, K., Soond, D. R., Piñeiro, R., Hagemann, T., Pearce, W., Lim, E. L., et al. (2014). Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Nature 510, 407-411. doi: 10.1038/nature13444
    • (2014) Nature , vol.510 , pp. 407-411
    • Ali, K.1    Soond, D.R.2    Piñeiro, R.3    Hagemann, T.4    Pearce, W.5    Lim, E.L.6
  • 2
    • 84888385324 scopus 로고    scopus 로고
    • Immunity, inflammation and cancer: a leading role for adenosine
    • Antonioli, L., Blandizzi, C., Pacher, P., and Haskó, G. (2013). Immunity, inflammation and cancer: a leading role for adenosine. Nat. Rev. Cancer 13, 842-857. doi: 10.1038/nrc3613
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 842-857
    • Antonioli, L.1    Blandizzi, C.2    Pacher, P.3    Haskó, G.4
  • 3
    • 84876786403 scopus 로고    scopus 로고
    • A starring role for stellate cells in the pancreatic cancer microenvironment
    • Apte, M. V., Wilson, J. S., Lugea, A., and Pandol, S. J. (2013). A starring role for stellate cells in the pancreatic cancer microenvironment. Gastroenterology 144, 1210-1219. doi: 10.1053/j.gastro.2012.11.037
    • (2013) Gastroenterology , vol.144 , pp. 1210-1219
    • Apte, M.V.1    Wilson, J.S.2    Lugea, A.3    Pandol, S.J.4
  • 4
    • 53149114909 scopus 로고    scopus 로고
    • The transforming functions of PI3-kinase-γ are linked to disruption of intercellular adhesion and promotion of cancer cell invasion
    • Attoub, S., De Wever, O., Bruyneel, E., Mareel, M., and Gespach, C. (2008). The transforming functions of PI3-kinase-γ are linked to disruption of intercellular adhesion and promotion of cancer cell invasion. Ann. N.Y. Acad. Sci. 1138, 204-213. doi: 10.1196/annals.1414.027
    • (2008) Ann. N. Y. Acad. Sci. , vol.1138 , pp. 204-213
    • Attoub, S.1    De Wever, O.2    Bruyneel, E.3    Mareel, M.4    Gespach, C.5
  • 5
    • 79551510805 scopus 로고    scopus 로고
    • Obesity and cancer risk: recent review and evidence
    • Basen-Engquist, K., and Chang, M. (2011). Obesity and cancer risk: recent review and evidence. Curr. Oncol. Rep. 13, 71-76. doi: 10.1007/s11912-010-0139-7
    • (2011) Curr. Oncol. Rep. , vol.13 , pp. 71-76
    • Basen-Engquist, K.1    Chang, M.2
  • 6
    • 80054811005 scopus 로고    scopus 로고
    • PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance
    • Becattini, B., Marone, R., Zani, F., Arsenijevic, D., Seydoux, J., Montani, J. P., et al. (2011). PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance. Proc. Natl. Acad. Sci. U.S.A. 108, E854-E863. doi: 10.1073/pnas.1106698108
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. E854-E863
    • Becattini, B.1    Marone, R.2    Zani, F.3    Arsenijevic, D.4    Seydoux, J.5    Montani, J.P.6
  • 7
    • 77953995931 scopus 로고    scopus 로고
    • The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation
    • Beer-Hammer, S., Zebedin, E., von Holleben, M., Alferink, J., Reis, B., Dresing, P., et al. (2010). The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation. J. Leuk. Biol. 87, 1083-1095. doi: 10.1189/jlb.0809585
    • (2010) J. Leuk. Biol. , vol.87 , pp. 1083-1095
    • Beer-Hammer, S.1    Zebedin, E.2    von Holleben, M.3    Alferink, J.4    Reis, B.5    Dresing, P.6
  • 8
    • 0034687278 scopus 로고    scopus 로고
    • A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells
    • Bénistant, C., Chapuis, H., and Roche, S. (2000). A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells. Oncogene 19, 5083-5090. doi: 10.1038/sj.onc.1203871
    • (2000) Oncogene , vol.19 , pp. 5083-5090
    • Bénistant, C.1    Chapuis, H.2    Roche, S.3
  • 10
    • 0041338049 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3′-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo
    • Bondar, V. M., Sweeney-Gotsch, B., Andreeff, M., Mills, G. B., and McConkey, D. J. (2002). Inhibition of the phosphatidylinositol 3′-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo. Mol. Cancer Ther. 1, 989-997.
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 989-997
    • Bondar, V.M.1    Sweeney-Gotsch, B.2    Andreeff, M.3    Mills, G.B.4    McConkey, D.J.5
  • 11
    • 84860215803 scopus 로고    scopus 로고
    • Metabolic risk factors and primary liver cancer in a prospective study of 578 700 adults
    • Borena, W., Strohmaier, S., Lukanova, A., Bjørge, T., Lindkvist, B., Hallmans, G., et al. (2012). Metabolic risk factors and primary liver cancer in a prospective study of 578,700 adults. Int. J. Cancer 131, 193-200. doi: 10.1002/ijc.26338
    • (2012) Int. J. Cancer , vol.131 , pp. 193-200
    • Borena, W.1    Strohmaier, S.2    Lukanova, A.3    Bjørge, T.4    Lindkvist, B.5    Hallmans, G.6
  • 12
    • 84859098993 scopus 로고    scopus 로고
    • KRAS mutant colorectal tumors: past and present
    • Brand, T. M., and Wheeler, D. L. (2012). KRAS mutant colorectal tumors: past and present. Small GTPases 3, 34-39. doi: 10.4161/sgtp.18751
    • (2012) Small GTPases , vol.3 , pp. 34-39
    • Brand, T.M.1    Wheeler, D.L.2
  • 13
    • 84861403733 scopus 로고    scopus 로고
    • Differential roles for the p101 and p84 regulatory subunits of PI3Kγ in tumor growth and metastasis
    • Brazzatti, J. A., Klingler-Hoffmann, M., Haylock-Jacobs, S., Harata-Lee, Y., Niu, M., Higgins, M. D., et al. (2012). Differential roles for the p101 and p84 regulatory subunits of PI3Kγ in tumor growth and metastasis. Oncogene 31, 2350-2361. doi: 10.1038/onc.2011.414
    • (2012) Oncogene , vol.31 , pp. 2350-2361
    • Brazzatti, J.A.1    Klingler-Hoffmann, M.2    Haylock-Jacobs, S.3    Harata-Lee, Y.4    Niu, M.5    Higgins, M.D.6
  • 14
    • 84899628178 scopus 로고    scopus 로고
    • Colorectal cancer
    • Brenner, H., Kloor, M., and Pox, C. P. (2014). Colorectal cancer. Lancet 383, 1490-1502. doi: 10.1016/S0140-6736(13)61649-9
    • (2014) Lancet , vol.383 , pp. 1490-1502
    • Brenner, H.1    Kloor, M.2    Pox, C.P.3
  • 15
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US. adults
    • Calle, E. E., Rodriguez, C., Walker-Thurmond, K., and Thun, M. J. (2003). Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N. Engl. J. Med. 348, 1625-1638. doi: 10.1056/NEJMoa021423
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 16
    • 77957154710 scopus 로고    scopus 로고
    • Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM)
    • Carter, H., Samayoa, J., Hruban, R. H., and Karchin, R. (2010). Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM). Cancer Biol. Ther. 10, 582-587. doi: 10.4161/cbt.10.6.12537
    • (2010) Cancer Biol. Ther. , vol.10 , pp. 582-587
    • Carter, H.1    Samayoa, J.2    Hruban, R.H.3    Karchin, R.4
  • 17
    • 0000440912 scopus 로고    scopus 로고
    • Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
    • Chang, H. W., Aoki, M., Fruman, D., Auger, K. R., Bellacosa, A., Tsichlis, P. N., et al. (1997). Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Science 276, 1848-1850. doi: 10.1126/science.276.5320.1848
    • (1997) Science , vol.276 , pp. 1848-1850
    • Chang, H.W.1    Aoki, M.2    Fruman, D.3    Auger, K.R.4    Bellacosa, A.5    Tsichlis, P.N.6
  • 18
    • 0037440004 scopus 로고    scopus 로고
    • Functional studies of the PI(3)-kinase signalling pathway employing synthetic and expressed siRNA
    • Czauderna, F., Fechtner, M., Aygün, H., Arnold, W., Klippel, A., Giese, K., et al. (2003). Functional studies of the PI(3)-kinase signalling pathway employing synthetic and expressed siRNA. Nucleic Acids Res. 31, 670-682. doi: 10.1093/nar/gkg141
    • (2003) Nucleic Acids Res , vol.31 , pp. 670-682
    • Czauderna, F.1    Fechtner, M.2    Aygün, H.3    Arnold, W.4    Klippel, A.5    Giese, K.6
  • 19
    • 4644232654 scopus 로고    scopus 로고
    • Defective dendritic cell migration and activation of adaptive immunity in P13Kgamma-deficient mice
    • Del Prete, A., Vermi, W., Dander, E., Otero, K., Barberis, L., Luini, W., et al. (2004). Defective dendritic cell migration and activation of adaptive immunity in P13Kgamma-deficient mice. Embo J. 23, 3505-3515. doi: 10.1038/sj.emboj.7600361
    • (2004) Embo J , vol.23 , pp. 3505-3515
    • Del Prete, A.1    Vermi, W.2    Dander, E.3    Otero, K.4    Barberis, L.5    Luini, W.6
  • 20
    • 84859156758 scopus 로고    scopus 로고
    • PI3K class IB controls the cell cycle checkpoint promoting cell proliferation in hepatocellular carcinoma
    • Dituri, F., Mazzocca, A., Lupo, L., Edling, C. E., Azzariti, A., Antonaci, S., et al. (2012). PI3K class IB controls the cell cycle checkpoint promoting cell proliferation in hepatocellular carcinoma. Int. J. Cancer 130, 2505-2513. doi: 10.1002/ijc.26319
    • (2012) Int. J. Cancer , vol.130 , pp. 2505-2513
    • Dituri, F.1    Mazzocca, A.2    Lupo, L.3    Edling, C.E.4    Azzariti, A.5    Antonaci, S.6
  • 21
    • 77958032063 scopus 로고    scopus 로고
    • Key role of phosphoinositide 3-kinase class IB in pancreatic cancer
    • Edling, C. E., Selvaggi, F., Buus, R., Maffucci, T., Di Sebastiano, P., Friess, H., et al. (2010). Key role of phosphoinositide 3-kinase class IB in pancreatic cancer. Clin. Cancer Res. 16, 4928-4937. doi: 10.1158/1078-0432.CCR-10-1210
    • (2010) Clin. Cancer Res. , vol.16 , pp. 4928-4937
    • Edling, C.E.1    Selvaggi, F.2    Buus, R.3    Maffucci, T.4    Di Sebastiano, P.5    Friess, H.6
  • 22
    • 84899863836 scopus 로고    scopus 로고
    • Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway
    • Edling, C. E., Selvaggi, F., Ghonaim, R., Maffucci, T., and Falasca, M. (2014). Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway. Cancer Biol. Ther. 15, 524-532. doi: 10.4161/cbt.28018
    • (2014) Cancer Biol. Ther. , vol.15 , pp. 524-532
    • Edling, C.E.1    Selvaggi, F.2    Ghonaim, R.3    Maffucci, T.4    Falasca, M.5
  • 23
    • 84888633713 scopus 로고    scopus 로고
    • Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms
    • Elinav, E., Nowarski, R., Thaiss, C. A., Hu, B., Jin, C., and Flavell, R. A. (2013). Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat. Rev. Cancer. 13, 759-771. doi: 10.1038/nrc3611
    • (2013) Nat. Rev. Cancer. , vol.13 , pp. 759-771
    • Elinav, E.1    Nowarski, R.2    Thaiss, C.A.3    Hu, B.4    Jin, C.5    Flavell, R.A.6
  • 24
    • 77950914672 scopus 로고    scopus 로고
    • PI3K/Akt signalling pathway specific inhibitors: a novel strategy to sensitize cancer cells to anti-cancer drugs
    • Falasca, M. (2010). PI3K/Akt signalling pathway specific inhibitors: a novel strategy to sensitize cancer cells to anti-cancer drugs. Curr. Pharm. Des. 16, 1410-1416. doi: 10.2174/138161210791033950
    • (2010) Curr. Pharm. Des. , vol.16 , pp. 1410-1416
    • Falasca, M.1
  • 25
    • 80053095056 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase pathway inhibitors: pharmacology, metabolism and drug development
    • Falasca, M. (2011). Phosphoinositide 3-kinase pathway inhibitors: pharmacology, metabolism and drug development. Curr. Med. Chem. 18, 2673. doi: 10.2174/092986711796011210
    • (2011) Curr. Med. Chem. , vol.18 , pp. 2673
    • Falasca, M.1
  • 26
    • 34247141906 scopus 로고    scopus 로고
    • Role of class II phosphoinositide 3-kinase in cell signalling
    • Falasca, M., and Maffucci, T. (2007). Role of class II phosphoinositide 3-kinase in cell signalling. Biochem. Soc. Trans. 35, 211-214. doi: 10.1042/BST0350211
    • (2007) Biochem. Soc. Trans. , vol.35 , pp. 211-214
    • Falasca, M.1    Maffucci, T.2
  • 27
    • 84860206692 scopus 로고    scopus 로고
    • Regulation and cellular functions of class II phosphoinositide 3-kinases
    • Falasca, M., and Maffucci, T. (2012). Regulation and cellular functions of class II phosphoinositide 3-kinases. Biochem J. 443, 587-601. doi: 10.1042/BJ20120008
    • (2012) Biochem J , vol.443 , pp. 587-601
    • Falasca, M.1    Maffucci, T.2
  • 28
    • 79958177923 scopus 로고    scopus 로고
    • Targeting phosphoinositide 3-kinase pathways in pancreatic cancer-from molecular signalling to clinical trials
    • Falasca, M., Selvaggi, F., Buus, R., Sulpizio, S., and Edling, C. E. (2011). Targeting phosphoinositide 3-kinase pathways in pancreatic cancer-from molecular signalling to clinical trials. Anticancer Agents Med. Chem. 11, 455-463. doi: 10.2174/187152011795677382
    • (2011) Anticancer Agents Med. Chem. , vol.11 , pp. 455-463
    • Falasca, M.1    Selvaggi, F.2    Buus, R.3    Sulpizio, S.4    Edling, C.E.5
  • 29
    • 84876724528 scopus 로고    scopus 로고
    • Genetic and epigenetic regulation of phosphoinositide 3-kinase isoforms
    • Fyffe, C., Buus, R., and Falasca, M. (2013). Genetic and epigenetic regulation of phosphoinositide 3-kinase isoforms. Curr. Pharm. Des. 19, 680-686. doi: 10.2174/138161213804581873
    • (2013) Curr. Pharm. Des. , vol.19 , pp. 680-686
    • Fyffe, C.1    Buus, R.2    Falasca, M.3
  • 30
    • 77949873730 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase gamma inhibition ameliorates inflammation and tumor growth in a model of colitis associated cancer
    • Gonzalez-Garcia, A., Sanchez-Ruiz, J., Flores, J. M., and Carrera, A. C. (2010). Phosphatidylinositol 3-kinase gamma inhibition ameliorates inflammation and tumor growth in a model of colitis associated cancer. Gastroenterology 138, 1374-1383. doi: 10.1053/j.gastro.2009.12.001
    • (2010) Gastroenterology , vol.138 , pp. 1374-1383
    • Gonzalez-Garcia, A.1    Sanchez-Ruiz, J.2    Flores, J.M.3    Carrera, A.C.4
  • 31
    • 84902482580 scopus 로고    scopus 로고
    • Pancreatic cancer stroma: friend or foe?
    • Gore, J., and Korc, M. (2014). Pancreatic cancer stroma: friend or foe? Cancer Cell 25, 711-712. doi: 10.1016/j.ccr.2014.05.026
    • (2014) Cancer Cell , vol.25 , pp. 711-712
    • Gore, J.1    Korc, M.2
  • 32
    • 44349119736 scopus 로고    scopus 로고
    • Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration
    • Graupera, M., Guillermet-Guibert, J., Foukas, L. C., Phng, L. K., Cain, R. J., Salpekar, A., et al. (2008). Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature 453, 662-666. doi: 10.1038/nature06892
    • (2008) Nature , vol.453 , pp. 662-666
    • Graupera, M.1    Guillermet-Guibert, J.2    Foukas, L.C.3    Phng, L.K.4    Cain, R.J.5    Salpekar, A.6
  • 33
    • 24344446438 scopus 로고    scopus 로고
    • The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
    • Hamada, K., Sasaki, T., Koni, P. A., Natsui, M., Kishimoto, H., Sasaki, J., et al. (2005). The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev. 19, 2054-2065. doi: 10.1101/gad.1308805
    • (2005) Genes Dev , vol.19 , pp. 2054-2065
    • Hamada, K.1    Sasaki, T.2    Koni, P.A.3    Natsui, M.4    Kishimoto, H.5    Sasaki, J.6
  • 34
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan, D., and Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. Cell 144, 646-674. doi: 10.1016/j.cell.2011.02.013
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 35
    • 84907449220 scopus 로고    scopus 로고
    • Pancreatic stellate cells and pancreas cancer: Current perspectives and future strategies
    • Haqq, J., Howells, L. M., Garcea, G., Metcalfe, M. S., Steward, W. P., and Dennison, A. R. (2014). Pancreatic stellate cells and pancreas cancer: Current perspectives and future strategies. Eur. J. Cancer. 50, 2570-2582. doi: 10.1016/j.ejca.2014.06.021
    • (2014) Eur. J. Cancer. , vol.50 , pp. 2570-2582
    • Haqq, J.1    Howells, L.M.2    Garcea, G.3    Metcalfe, M.S.4    Steward, W.P.5    Dennison, A.R.6
  • 36
    • 78650859531 scopus 로고    scopus 로고
    • NF-κ B and STAT3-key players in liver inflammation and cancer
    • He, G., and Karin, M. (2011). NF-κ B and STAT3-key players in liver inflammation and cancer. Cell Res. 21, 159-168. doi: 10.1038/cr.2010.183
    • (2011) Cell Res , vol.21 , pp. 159-168
    • He, G.1    Karin, M.2
  • 37
    • 51749104480 scopus 로고    scopus 로고
    • Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells
    • Heller, R., Chang, Q., Ehrlich, G., Hsieh, S. N., Schoenwaelder, S. M., Kuhlencordt, P. J., et al. (2008). Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells. Cardiovasc. Res. 80, 96-105. doi: 10.1093/cvr/cvn159
    • (2008) Cardiovasc. Res. , vol.80 , pp. 96-105
    • Heller, R.1    Chang, Q.2    Ehrlich, G.3    Hsieh, S.N.4    Schoenwaelder, S.M.5    Kuhlencordt, P.J.6
  • 38
    • 33646370512 scopus 로고    scopus 로고
    • BCR-ABL regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation and is required for proliferation and drug resistance
    • Hickey, F. B., and Cotter, T. G. (2006). BCR-ABL regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation and is required for proliferation and drug resistance. J. Biol. Chem. 281, 2441-2450. doi: 10.1074/jbc.M511173200
    • (2006) J. Biol. Chem. , vol.281 , pp. 2441-2450
    • Hickey, F.B.1    Cotter, T.G.2
  • 39
  • 40
    • 84902470158 scopus 로고    scopus 로고
    • PI3K in cancer-stroma interactions: bad in seed and ugly in soil
    • Hirsch, E., Ciraolo, E., Franco, I., Ghigo, A., and Martini, M. (2014). PI3K in cancer-stroma interactions: bad in seed and ugly in soil. Oncogene 33, 3083-3090. doi: 10.1038/onc.2013.265
    • (2014) Oncogene , vol.33 , pp. 3083-3090
    • Hirsch, E.1    Ciraolo, E.2    Franco, I.3    Ghigo, A.4    Martini, M.5
  • 41
    • 0034635452 scopus 로고    scopus 로고
    • Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation
    • Hirsch, E., Katanaev, V. L., Garlanda, C., Azzolino, O., Pirola, L., Silengo, L., et al. (2000). Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 287, 1049-1053. doi: 10.1126/science.287.5455.1049
    • (2000) Science , vol.287 , pp. 1049-1053
    • Hirsch, E.1    Katanaev, V.L.2    Garlanda, C.3    Azzolino, O.4    Pirola, L.5    Silengo, L.6
  • 45
    • 31944448780 scopus 로고    scopus 로고
    • Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase
    • Kang, S., Denley, A., Vanhaesebroeck, B., and Vogt, P. K. (2006). Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase. Proc. Natl. Acad. Sci. U.S.A. 103, 1289-1294. doi: 10.1073/pnas.0510772103
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 1289-1294
    • Kang, S.1    Denley, A.2    Vanhaesebroeck, B.3    Vogt, P.K.4
  • 46
    • 84899447215 scopus 로고    scopus 로고
    • Obesity-associated mechanisms of hepatocarcinogenesis
    • Karagozian, R., Derdák, Z., and Baffy, G. (2014). Obesity-associated mechanisms of hepatocarcinogenesis. Metabolism 63, 607-617. doi: 10.1016/j.metabol.2014.01.011
    • (2014) Metabolism , vol.63 , pp. 607-617
    • Karagozian, R.1    Derdák, Z.2    Baffy, G.3
  • 47
    • 0030913673 scopus 로고    scopus 로고
    • Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
    • Khwaja, A., Rodriguez-Viciana, P., Wennström, S., Warne, P. H., and Downward, J. (1997). Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16, 2783-2793. doi: 10.1093/emboj/16.10.2783
    • (1997) EMBO J , vol.16 , pp. 2783-2793
    • Khwaja, A.1    Rodriguez-Viciana, P.2    Wennström, S.3    Warne, P.H.4    Downward, J.5
  • 48
    • 0242499482 scopus 로고    scopus 로고
    • Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3′-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas
    • Knobbe, C. B., and Reifenberger, G. (2003). Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3′-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas. Brain Pathol. 13, 507-518. doi: 10.1111/j.1750-3639.2003.tb00481.x
    • (2003) Brain Pathol , vol.13 , pp. 507-518
    • Knobbe, C.B.1    Reifenberger, G.2
  • 49
    • 79955012753 scopus 로고    scopus 로고
    • Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance
    • Kobayashi, N., Ueki, K., Okazaki, Y., Iwane, A., Kubota, N., Ohsugi, M., et al. (2011). Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance. Proc. Natl. Acad. Sci. U.S.A. 108, 5753-5758. doi: 10.1073/pnas.1016430108
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 5753-5758
    • Kobayashi, N.1    Ueki, K.2    Okazaki, Y.3    Iwane, A.4    Kubota, N.5    Ohsugi, M.6
  • 51
    • 0033973253 scopus 로고    scopus 로고
    • Tobacco smoking, alcohol consumption and their interaction in the causation of hepatocellular carcinoma
    • Kuper, H., Tzonou, A., Kaklamani, E., Hsieh, C. C., Lagiou, P., Adami, H. O., et al. (2000). Tobacco smoking, alcohol consumption and their interaction in the causation of hepatocellular carcinoma. Int. J. Cancer 85, 498-502. doi: 10.1002/(SICI)1097-0215(20000215)85:4<498::AID-IJC9>3.0.CO;2-F
    • (2000) Int. J. Cancer , vol.85 , pp. 498-502
    • Kuper, H.1    Tzonou, A.2    Kaklamani, E.3    Hsieh, C.C.4    Lagiou, P.5    Adami, H.O.6
  • 52
    • 84904994417 scopus 로고    scopus 로고
    • Stromal response to Hedgehog signaling restrains pancreatic cancer progression
    • Lee, J. J., Perera, R. M., Wang, H., Wu, D. C., Liu, X. S., Han, S., et al. (2014). Stromal response to Hedgehog signaling restrains pancreatic cancer progression. Proc. Natl. Acad. Sci. U.S.A. 111, E3091-E3100. doi: 10.1073/pnas.1411679111
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , pp. E3091-E3100
    • Lee, J.J.1    Perera, R.M.2    Wang, H.3    Wu, D.C.4    Liu, X.S.5    Han, S.6
  • 53
    • 1642588228 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Li, D., Xie, K., Wolff, R., and Abbruzzese, J. L. (2004). Pancreatic cancer. Lancet 363, 1049-1057. doi: 10.1016/S0140-6736(04)15841-8
    • (2004) Lancet , vol.363 , pp. 1049-1057
    • Li, D.1    Xie, K.2    Wolff, R.3    Abbruzzese, J.L.4
  • 54
    • 84865168855 scopus 로고    scopus 로고
    • Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing
    • Liu, P., Morrison, C., Wang, L., Xiong, D., Vedell, P., Cui, P., et al. (2012). Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing. Carcinogenesis 33, 1270-1276. doi: 10.1093/carcin/bgs148
    • (2012) Carcinogenesis , vol.33 , pp. 1270-1276
    • Liu, P.1    Morrison, C.2    Wang, L.3    Xiong, D.4    Vedell, P.5    Cui, P.6
  • 55
    • 18844375044 scopus 로고    scopus 로고
    • Treatment for pancreatic cancer: current therapy and continued progress
    • Lockhart, A. C., Rothenberg, M. L., and Berlin, J. D. (2005). Treatment for pancreatic cancer: current therapy and continued progress. Gastroenterology 128, 1642-1654. doi: 10.1053/j.gastro.2005.03.039
    • (2005) Gastroenterology , vol.128 , pp. 1642-1654
    • Lockhart, A.C.1    Rothenberg, M.L.2    Berlin, J.D.3
  • 56
    • 0142227019 scopus 로고    scopus 로고
    • Targeting the PI3K-Akt pathway in human cancer: rationale and promise
    • Luo, J., Manning, B. D., and Cantley, L. C. (2003). Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 4, 257-262. doi: 10.1016/S1535-6108(03)00248-4
    • (2003) Cancer Cell , vol.4 , pp. 257-262
    • Luo, J.1    Manning, B.D.2    Cantley, L.C.3
  • 57
    • 37549023783 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase gamma gene knockout impairs postischemic neovascularization and endothelial progenitor cell functions
    • Madeddu, P., Kraenkel, N., Barcelos, L. S., Siragusa, M., Campagnolo, P., Oikawa, A., et al. (2008). Phosphoinositide 3-kinase gamma gene knockout impairs postischemic neovascularization and endothelial progenitor cell functions. Arterioscler. Thromb. Vasc. Biol. 28, 68-76. doi: 10.1161/ATVBAHA.107.145573
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , pp. 68-76
    • Madeddu, P.1    Kraenkel, N.2    Barcelos, L.S.3    Siragusa, M.4    Campagnolo, P.5    Oikawa, A.6
  • 58
    • 51049109033 scopus 로고    scopus 로고
    • Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
    • Maira, S. M., Stauffer, F., Brueggen, J., Furet, P., Schnell, C., Fritsch, C., et al. (2008). Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol. Cancer Ther. 7, 1851-1863. doi: 10.1158/1535-7163.MCT-08-0017
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 1851-1863
    • Maira, S.M.1    Stauffer, F.2    Brueggen, J.3    Furet, P.4    Schnell, C.5    Fritsch, C.6
  • 59
    • 8544223594 scopus 로고    scopus 로고
    • Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4
    • Marchesi, F., Monti, P., Leone, B. E., Zerbi, A., Vecchi, A., Piemonti, L., et al. (2004). Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4. Cancer Res. 64, 8420-8427. doi: 10.1158/0008-5472.CAN-04-1343
    • (2004) Cancer Res , vol.64 , pp. 8420-8427
    • Marchesi, F.1    Monti, P.2    Leone, B.E.3    Zerbi, A.4    Vecchi, A.5    Piemonti, L.6
  • 60
    • 0028302476 scopus 로고
    • Obesity and cancer risk: a Danish record-linkage study
    • Møller, H., Mellemgaard, A., Lindvig, K., and Olsen, J. H. (1994). Obesity and cancer risk: a Danish record-linkage study. Eur. J. Cancer. 30A, 344-350. doi: 10.1016/0959-8049(94)90254-2
    • (1994) Eur. J. Cancer. , vol.30 A , pp. 344-350
    • Møller, H.1    Mellemgaard, A.2    Lindvig, K.3    Olsen, J.H.4
  • 62
    • 67449152446 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase signalling in the vascular system
    • Morello, F., Perino, A., and Hirsch, E. (2009). Phosphoinositide 3-kinase signalling in the vascular system. Cardiovasc. Res. 82, 261-271. doi: 10.1093/cvr/cvn325
    • (2009) Cardiovasc. Res. , vol.82 , pp. 261-271
    • Morello, F.1    Perino, A.2    Hirsch, E.3
  • 63
    • 0030988302 scopus 로고    scopus 로고
    • p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma
    • Moskaluk, C. A., Hruban, R. H., and Kern, S. E. (1997). p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res. 57, 2140-2143.
    • (1997) Cancer Res , vol.57 , pp. 2140-2143
    • Moskaluk, C.A.1    Hruban, R.H.2    Kern, S.E.3
  • 64
    • 63049090100 scopus 로고    scopus 로고
    • Metastasis: from dissemination to organ-specific colonization
    • Nguyen, D. X., Bos, P. D., and Massagué, J. (2009). Metastasis: from dissemination to organ-specific colonization. Nat. Rev. Cancer 9, 274-284. doi: 10.1038/nrc2622
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Massagué, J.3
  • 65
    • 34247269026 scopus 로고    scopus 로고
    • Genetic determinants of cancer metastasis
    • Nguyen, D. X., and Massague, J. (2007). Genetic determinants of cancer metastasis. Nat. Rev. Genet. 8, 341-352. doi: 10.1038/nrg2101
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 341-352
    • Nguyen, D.X.1    Massague, J.2
  • 66
    • 84902469661 scopus 로고    scopus 로고
    • Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
    • Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C. C., Simpson, T. R., et al. (2014). Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell 25, 719-734. doi: 10.1016/j.ccr.2014.04.005
    • (2014) Cancer Cell , vol.25 , pp. 719-734
    • Özdemir, B.C.1    Pentcheva-Hoang, T.2    Carstens, J.L.3    Zheng, X.4    Wu, C.C.5    Simpson, T.R.6
  • 67
    • 4344714889 scopus 로고    scopus 로고
    • P13Kgamma modulates the cardiac response to chronic pressure overload by distinct Kinase-dependent and -independent effects
    • Patrucco, E., Notte, A., Barberis, L., Selvetella, G., Maffei, A., Brancaccio, M., et al. (2004). P13Kgamma modulates the cardiac response to chronic pressure overload by distinct Kinase-dependent and -independent effects. Cell 118, 375-387. doi: 10.1016/j.cell.2004.07.017
    • (2004) Cell , vol.118 , pp. 375-387
    • Patrucco, E.1    Notte, A.2    Barberis, L.3    Selvetella, G.4    Maffei, A.5    Brancaccio, M.6
  • 68
    • 33745662579 scopus 로고    scopus 로고
    • Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma
    • Pomel, V., Klicic, J., Covini, D., Church, D. D., Shaw, J. P., Roulin, K., et al. (2006). Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. J. Med. Chem. 49, 3857-3871. doi: 10.1021/jm0601598
    • (2006) J. Med. Chem. , vol.49 , pp. 3857-3871
    • Pomel, V.1    Klicic, J.2    Covini, D.3    Church, D.D.4    Shaw, J.P.5    Roulin, K.6
  • 69
    • 0029823946 scopus 로고    scopus 로고
    • A tyrosine kinase signaling pathway accounts for the majority of phosphatidylinositol 3,4 5-trisphosphate formation in chemoattractant-stimulated human neutrophils
    • Ptasznik, A., Prossnitz, E. R., Yoshikawa, D., Smrcka, A., Traynor-Kaplan, A. E., and Bokoch, G. M. (1996). A tyrosine kinase signaling pathway accounts for the majority of phosphatidylinositol 3,4,5-trisphosphate formation in chemoattractant-stimulated human neutrophils. J. Biol. Chem. 271, 25204-25207. doi: 10.1074/jbc.271.41.25204
    • (1996) J. Biol. Chem. , vol.271 , pp. 25204-25207
    • Ptasznik, A.1    Prossnitz, E.R.2    Yoshikawa, D.3    Smrcka, A.4    Traynor-Kaplan, A.E.5    Bokoch, G.M.6
  • 70
    • 84887444879 scopus 로고    scopus 로고
    • Microenvironmental regulation of tumor progression and metastasis
    • Quail, D. F., and Joyce, J. A. (2013). Microenvironmental regulation of tumor progression and metastasis. Nat. Med. 19, 1423-1437. doi: 10.1038/nm.3394
    • (2013) Nat. Med. , vol.19 , pp. 1423-1437
    • Quail, D.F.1    Joyce, J.A.2
  • 71
    • 47049113462 scopus 로고    scopus 로고
    • Role of P13Kdelta and P13Kgamma in inflammatory arthritis and tissue localization of neutrophils
    • Randis, T. M., Puri, K. D., Zhou, H., and Diacovo, T. G. (2008). Role of P13Kdelta and P13Kgamma in inflammatory arthritis and tissue localization of neutrophils. Eur. J. Immunol. 38, 1215-1224. doi: 10.1002/eji.200838266
    • (2008) Eur. J. Immunol. , vol.38 , pp. 1215-1224
    • Randis, T.M.1    Puri, K.D.2    Zhou, H.3    Diacovo, T.G.4
  • 72
    • 34250823572 scopus 로고    scopus 로고
    • Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases
    • Raynaud, F. I., Eccles, S., Clarke, P. A., Hayes, A., Nutley, B., Alix, S., et al. (2007). Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases. Cancer Res. 67, 5840-5850. doi: 10.1158/0008-5472.CAN-06-4615
    • (2007) Cancer Res , vol.67 , pp. 5840-5850
    • Raynaud, F.I.1    Eccles, S.2    Clarke, P.A.3    Hayes, A.4    Nutley, B.5    Alix, S.6
  • 73
    • 38949108241 scopus 로고    scopus 로고
    • Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
    • Renehan, A. G., Tyson, M., Egger, M., Heller, R. F., and Zwahlen, M. (2008). Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371, 569-578. doi: 10.1016/S0140-6736(08)60269-X
    • (2008) Lancet , vol.371 , pp. 569-578
    • Renehan, A.G.1    Tyson, M.2    Egger, M.3    Heller, R.F.4    Zwahlen, M.5
  • 74
    • 84902435628 scopus 로고    scopus 로고
    • Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
    • Rhim, A. D., Oberstein, P. E., Thomas, D. H., Mirek, E. T., Palermo, C. F., Sastra, S. A., et al. (2014). Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 25, 735-747. doi: 10.1016/j.ccr.2014.04.021
    • (2014) Cancer Cell , vol.25 , pp. 735-747
    • Rhim, A.D.1    Oberstein, P.E.2    Thomas, D.H.3    Mirek, E.T.4    Palermo, C.F.5    Sastra, S.A.6
  • 75
    • 0037407560 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults
    • Ryder, S. D. (2003). Guidelines for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults. Gut 52(Suppl. 3), iii1-iii8. doi: 10.1136/gut.52.suppl_3.iii1
    • (2003) Gut , vol.52 , pp. 31-38
    • Ryder, S.D.1
  • 76
    • 0037369696 scopus 로고    scopus 로고
    • Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement
    • Sadhu, C., Masinovsky, B., Dick, K., Sowell, C. G., and Staunton, D. E. (2003). Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J. Immunol. 170, 2647-2654. doi: 10.4049/jimmunol.170.5.2647
    • (2003) J. Immunol. , vol.170 , pp. 2647-2654
    • Sadhu, C.1    Masinovsky, B.2    Dick, K.3    Sowell, C.G.4    Staunton, D.E.5
  • 77
    • 33746089143 scopus 로고    scopus 로고
    • Relation of body mass index to cancer risk in 362 552 Swedish men
    • Samanic, C., Chow, W. H., Gridley, G., Jarvholm, B., and Fraumeni, J. F. Jr. (2006). Relation of body mass index to cancer risk in 362,552 Swedish men. Cancer Causes Control 17, 901-909. doi: 10.1007/s10552-006-0023-9
    • (2006) Cancer Causes Control , vol.17 , pp. 901-909
    • Samanic, C.1    Chow, W.H.2    Gridley, G.3    Jarvholm, B.4    Fraumeni Jr, J.F.5
  • 78
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Samuels, Y., Wang, Z., Bardelli, A., Silliman, N., Ptak, J., Szabo, S., et al. (2004). High frequency of mutations of the PIK3CA gene in human cancers. Science 304, 554. doi: 10.1126/science.1096502
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1    Wang, Z.2    Bardelli, A.3    Silliman, N.4    Ptak, J.5    Szabo, S.6
  • 79
    • 0034710675 scopus 로고    scopus 로고
    • Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma
    • Sasaki, T., Irie-Sasaki, J., Horie, Y., Bachmaier, K., Fata, J. E., Li, M., et al. (2000). Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma. Nature 406, 897-902. doi: 10.1038/35022585
    • (2000) Nature , vol.406 , pp. 897-902
    • Sasaki, T.1    Irie-Sasaki, J.2    Horie, Y.3    Bachmaier, K.4    Fata, J.E.5    Li, M.6
  • 80
    • 0347504834 scopus 로고    scopus 로고
    • Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma
    • Sasaki, T., Irie-Sasaki, J., Horie, Y., Bachmaier, K., Fata, J. E., Li, M., et al. (2003). Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma. Nature 426, 584. doi: 10.1038/nature02203
    • (2003) Nature , vol.426 , pp. 584
    • Sasaki, T.1    Irie-Sasaki, J.2    Horie, Y.3    Bachmaier, K.4    Fata, J.E.5    Li, M.6
  • 81
    • 0037381002 scopus 로고    scopus 로고
    • Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta
    • Sawyer, C., Sturge, J., Bennett, D. C., O'Hare, M. J., Allen, W. E., Bain, J., et al. (2003). Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta. Cancer Res. 63, 1667-1675.
    • (2003) Cancer Res , vol.63 , pp. 1667-1675
    • Sawyer, C.1    Sturge, J.2    Bennett, D.C.3    O'Hare, M.J.4    Allen, W.E.5    Bain, J.6
  • 82
    • 84870251301 scopus 로고    scopus 로고
    • Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort
    • Schlesinger, S., Aleksandrova, K., Pischon, T., Fedirko, V., Jenab, M., Trepo, E., et al. (2013). Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort. Int. J. Cancer 132, 645-657. doi: 10.1002/ijc.27645
    • (2013) Int. J. Cancer , vol.132 , pp. 645-657
    • Schlesinger, S.1    Aleksandrova, K.2    Pischon, T.3    Fedirko, V.4    Jenab, M.5    Trepo, E.6
  • 83
    • 0348049845 scopus 로고    scopus 로고
    • Incidence, mechanism and prognostic value of activated AKT in pancreas cancer
    • Schlieman, M. G., Fahy, B. N., Ramsamooj, R., Beckett, L., and Bold, R. J. (2003). Incidence, mechanism and prognostic value of activated AKT in pancreas cancer. Br. J. Cancer. 89, 2110-2115. doi: 10.1038/sj.bjc.6601396
    • (2003) Br. J. Cancer. , vol.89 , pp. 2110-2115
    • Schlieman, M.G.1    Fahy, B.N.2    Ramsamooj, R.3    Beckett, L.4    Bold, R.J.5
  • 84
    • 79958696667 scopus 로고    scopus 로고
    • Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression
    • Schmid, M. C., Avraamides, C. J., Dippold, H. C., Franco, I., Foubert, P., Ellies, L. G., et al. (2011). Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression. Cancer Cell. 19, 715-727. doi: 10.1016/j.ccr.2011.04.016
    • (2011) Cancer Cell , vol.19 , pp. 715-727
    • Schmid, M.C.1    Avraamides, C.J.2    Dippold, H.C.3    Franco, I.4    Foubert, P.5    Ellies, L.G.6
  • 85
    • 18844431062 scopus 로고    scopus 로고
    • Pancreatic cancer: basic and clinical aspects
    • Schneider, G., Siveke, J. T., Eckel, F., and Schmid, R. M. (2005). Pancreatic cancer: basic and clinical aspects. Gastroenterology 128, 1606-1625. doi: 10.1053/j.gastro.2005.04.001
    • (2005) Gastroenterology , vol.128 , pp. 1606-1625
    • Schneider, G.1    Siveke, J.T.2    Eckel, F.3    Schmid, R.M.4
  • 86
    • 84903579347 scopus 로고    scopus 로고
    • Clinical trials in hepatocellular carcinoma: an update
    • Shen, Y. C., Lin, Z. Z., Hsu, C. H., Hsu, C., Shao, Y. Y., and Cheng, A. L. (2013). Clinical trials in hepatocellular carcinoma: an update. Liver Cancer 2, 345-364. doi: 10.1159/000343850
    • (2013) Liver Cancer , vol.2 , pp. 345-364
    • Shen, Y.C.1    Lin, Z.Z.2    Hsu, C.H.3    Hsu, C.4    Shao, Y.Y.5    Cheng, A.L.6
  • 88
    • 84857875585 scopus 로고    scopus 로고
    • PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances
    • So, L., and Fruman, D. A. (2012). PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances. Biochem. J. 442, 465-481. doi: 10.1042/BJ20112092
    • (2012) Biochem. J. , vol.442 , pp. 465-481
    • So, L.1    Fruman, D.A.2
  • 89
    • 22544444889 scopus 로고    scopus 로고
    • Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia
    • Sujobert, P., Bardet, V., Cornillet-Lefebvre, P., Hayflick, J. S., Prie, N., Verdier, F., et al. (2005). Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia. Blood 106, 1063-1066. doi: 10.1182/blood-2004-08-3225
    • (2005) Blood , vol.106 , pp. 1063-1066
    • Sujobert, P.1    Bardet, V.2    Cornillet-Lefebvre, P.3    Hayflick, J.S.4    Prie, N.5    Verdier, F.6
  • 90
    • 84903381578 scopus 로고    scopus 로고
    • The therapeutic value of targeting inflammation in gastrointestinal cancers
    • Sun, B., and Karin, M. (2014). The therapeutic value of targeting inflammation in gastrointestinal cancers. Trends Pharmacol. Sci. 35, 349-357. doi: 10.1016/j.tips.2014.04.011
    • (2014) Trends Pharmacol. Sci. , vol.35 , pp. 349-357
    • Sun, B.1    Karin, M.2
  • 91
    • 1842430485 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol 3′-kinase-Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines
    • Takeda, A., Osaki, M., Adachi, K., Honjo, S., and Ito, H. (2004). Role of the phosphatidylinositol 3′-kinase-Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines. Pancreas 28, 353-358. doi: 10.1097/00006676-200404000-00026
    • (2004) Pancreas , vol.28 , pp. 353-358
    • Takeda, A.1    Osaki, M.2    Adachi, K.3    Honjo, S.4    Ito, H.5
  • 92
    • 77957603190 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: consensus recommendations of the National Cancer Institute Clinical Trials Planning Meeting
    • Thomas, M. B., Jaffe, D., Choti, M. M., Belghiti, J., Curley, S., Fong, Y., et al. (2010). Hepatocellular carcinoma: consensus recommendations of the National Cancer Institute Clinical Trials Planning Meeting. J. Clin. Oncol. 28, 3994-4005. doi: 10.1200/JCO.2010.28.7805
    • (2010) J. Clin. Oncol. , vol.28 , pp. 3994-4005
    • Thomas, M.B.1    Jaffe, D.2    Choti, M.M.3    Belghiti, J.4    Curley, S.5    Fong, Y.6
  • 93
    • 40549116620 scopus 로고    scopus 로고
    • Systemic therapy for hepatocellular carcinoma: cytotoxic chemotherapy, targeted therapy and immunotherapy
    • Thomas, M. B., O'Beirne, J. P., Furuse, J., Chan, A. T., Abou-Alfa, G., and Johnson, P. (2008). Systemic therapy for hepatocellular carcinoma: cytotoxic chemotherapy, targeted therapy and immunotherapy. Ann. Surg. Oncol. 15, 1008-1014. doi: 10.1245/s10434-007-9705-0
    • (2008) Ann. Surg. Oncol. , vol.15 , pp. 1008-1014
    • Thomas, M.B.1    O'Beirne, J.P.2    Furuse, J.3    Chan, A.T.4    Abou-Alfa, G.5    Johnson, P.6
  • 94
    • 84888143815 scopus 로고    scopus 로고
    • The diagnosis and management of gastric cancer
    • Thrumurthy, S. G., Chaudry, M. A., Hochhauser, D., and Mughal, M. (2013). The diagnosis and management of gastric cancer. BMJ 347, f6367. doi: 10.1136/bmj.f6367
    • (2013) BMJ , vol.347 , pp. f6367
    • Thrumurthy, S.G.1    Chaudry, M.A.2    Hochhauser, D.3    Mughal, M.4
  • 95
    • 84872186366 scopus 로고    scopus 로고
    • Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis
    • Tibolla, G., Piñeiro, R., Chiozzotto, D., Mavrommati, I., Wheeler, A. P., Norata, G. D., et al. (2013). Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis. PLoS ONE 8:e53808. doi: 10.1371/journal.pone.0053808.
    • (2013) PLoS ONE , vol.8 , pp. e53808
    • Tibolla, G.1    Piñeiro, R.2    Chiozzotto, D.3    Mavrommati, I.4    Wheeler, A.P.5    Norata, G.D.6
  • 96
    • 0023810588 scopus 로고
    • An inositol tetrakisphosphate-containing phospholipid in activated neutrophils
    • Traynor-Kaplan, A. E., Harris, A. L., Thompson, B. L., Taylor, P., and Sklar, L. A. (1988). An inositol tetrakisphosphate-containing phospholipid in activated neutrophils. Nature 334, 353-356. doi: 10.1038/334353a0
    • (1988) Nature , vol.334 , pp. 353-356
    • Traynor-Kaplan, A.E.1    Harris, A.L.2    Thompson, B.L.3    Taylor, P.4    Sklar, L.A.5
  • 100
    • 34247534260 scopus 로고    scopus 로고
    • Regulation and biological activities of the autotaxin-LPA axis
    • Van Meeteren, L. A., and Moolenaar, W. H. (2007). Regulation and biological activities of the autotaxin-LPA axis. Prog. Lipid Res. 46, 145-160. doi: 10.1016/j.plipres.2007.02.001
    • (2007) Prog. Lipid Res. , vol.46 , pp. 145-160
    • Van Meeteren, L.A.1    Moolenaar, W.H.2
  • 101
    • 77953116018 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase gamma (P13Kgamma) inhibitors for the treatment of inflammation and autoimmune disease
    • Venable, J. D., Ameriks, M. K., Blevitt, J. M., Thurmond, R. L., and Fung-Leung, W. P. (2010). Phosphoinositide 3-kinase gamma (P13Kgamma) inhibitors for the treatment of inflammation and autoimmune disease. Recent Pat. Inflamm. Allergy Drug Discov. 4, 1-15. doi: 10.2174/187221310789895603
    • (2010) Recent Pat. Inflamm. Allergy Drug Discov. , vol.4 , pp. 1-15
    • Venable, J.D.1    Ameriks, M.K.2    Blevitt, J.M.3    Thurmond, R.L.4    Fung-Leung, W.P.5
  • 102
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate
    • Ward, P. S., and Thompson, C. B. (2012). Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate. Cancer Cell 21, 297-308. doi: 10.1016/j.ccr.2012.02.014
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 103
    • 84881232071 scopus 로고    scopus 로고
    • Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer
    • Welti, J., Loges, S., Dimmeler, S., and Carmeliet, P. (2013). Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer. J. Clin. Invest. 123, 3190-3200. doi: 10.1172/JCI70212
    • (2013) J. Clin. Invest. , vol.123 , pp. 3190-3200
    • Welti, J.1    Loges, S.2    Dimmeler, S.3    Carmeliet, P.4
  • 104
    • 84888219144 scopus 로고    scopus 로고
    • PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models
    • Winkler, D. G., Faia, K. L., DiNitto, J. P., Ali, J. A., White, K. F., Brophy, E. E., et al. (2013). PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models. Chem. Biol. 20, 1364-1374. doi: 10.1016/j.chembiol.2013.09.017
    • (2013) Chem. Biol. , vol.20 , pp. 1364-1374
    • Winkler, D.G.1    Faia, K.L.2    DiNitto, J.P.3    Ali, J.A.4    White, K.F.5    Brophy, E.E.6
  • 106
    • 84876679729 scopus 로고    scopus 로고
    • Identification of upregulated phosphoinositide 3-kinase γ as a target to suppress breast cancer cell migration and invasion
    • Xie, Y., Abel, P. W., Kirui, J. K., Deng, C., Sharma, P., Wolff, D. W., et al. (2013). Identification of upregulated phosphoinositide 3-kinase γ as a target to suppress breast cancer cell migration and invasion. Biochem. Pharmacol. 85, 1454-1462. doi: 10.1016/j.bcp.2013.03.001
    • (2013) Biochem. Pharmacol. , vol.85 , pp. 1454-1462
    • Xie, Y.1    Abel, P.W.2    Kirui, J.K.3    Deng, C.4    Sharma, P.5    Wolff, D.W.6
  • 107
    • 11144354317 scopus 로고    scopus 로고
    • Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma
    • Yamamoto, S., Tomita, Y., Hoshida, Y., Morooka, T., Nagano, H., Dono, K., et al. (2004). Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma. Clin. Cancer Res. 10, 2846-2850. doi: 10.1158/1078-0432.CCR-02-1441
    • (2004) Clin. Cancer Res. , vol.10 , pp. 2846-2850
    • Yamamoto, S.1    Tomita, Y.2    Hoshida, Y.3    Morooka, T.4    Nagano, H.5    Dono, K.6
  • 108
    • 84892896996 scopus 로고    scopus 로고
    • Prediagnostic body mass index and pancreatic cancer survival
    • Yuan, C., Bao, Y., Wu, C., Kraft, P., Ogino, S., Ng, K., et al. (2013). Prediagnostic body mass index and pancreatic cancer survival. J. Clin. Oncol. 31, 4229-4234. doi: 10.1200/JCO.2013.51.7532
    • (2013) J. Clin. Oncol. , vol.31 , pp. 4229-4234
    • Yuan, C.1    Bao, Y.2    Wu, C.3    Kraft, P.4    Ogino, S.5    Ng, K.6
  • 109
    • 51849111556 scopus 로고    scopus 로고
    • PI3K pathway alterations in cancer: variations on a theme
    • Yuan, T. L., and Cantley, L. C. (2008). PI3K pathway alterations in cancer: variations on a theme. Oncogene 27, 5497-5510. doi: 10.1038/onc.2008.245
    • (2008) Oncogene , vol.27 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 110
    • 84883851981 scopus 로고    scopus 로고
    • Epidemiology of esophageal cancer
    • Zhang, Y. (2013). Epidemiology of esophageal cancer. World J. Gastroenterol. 19, 5598-5606. doi: 10.3748/wjg.v19.i34.5598
    • (2013) World J. Gastroenterol. , vol.19 , pp. 5598-5606
    • Zhang, Y.1
  • 111
    • 51849128358 scopus 로고    scopus 로고
    • Class I PI3K in oncogenic cellular transformation
    • Zhao, L., and Vogt, P. K. (2008). Class I PI3K in oncogenic cellular transformation. Oncogene 27, 5486-5496. doi: 10.1038/onc.2008.244
    • (2008) Oncogene , vol.27 , pp. 5486-5496
    • Zhao, L.1    Vogt, P.K.2
  • 112
    • 80054113770 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma
    • Zhou, Q., Lui, V. W., and Yeo, W. (2011). Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma. Future Oncol. 7, 1149-1167. doi: 10.2217/fon.11.95
    • (2011) Future Oncol , vol.7 , pp. 1149-1167
    • Zhou, Q.1    Lui, V.W.2    Yeo, W.3
  • 113
    • 50149115138 scopus 로고    scopus 로고
    • Structural analysis of P13-kinase isoforms: identification of residues enabling selective inhibition by small molecule ATP-competitive inhibitors
    • Zvelebil, M. J., Waterfield, M. D., and Shuttleworth, S. J. (2008). Structural analysis of P13-kinase isoforms: identification of residues enabling selective inhibition by small molecule ATP-competitive inhibitors. Arch. Biochem. Biophys. 477, 404-410. doi: 10.1016/j.abb.2008.06.024
    • (2008) Arch. Biochem. Biophys. , vol.477 , pp. 404-410
    • Zvelebil, M.J.1    Waterfield, M.D.2    Shuttleworth, S.J.3


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