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Volumn 31, Issue 2, 2003, Pages 670-682

Functional studies of the PI(3)-kinase signalling pathway employing synthetic and expressed siRNA

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTISENSE OLIGONUCLEOTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN SUBUNIT; RIBONUCLEASE; RNA;

EID: 0037440004     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkg141     Document Type: Review
Times cited : (97)

References (54)
  • 1
    • 0033198944 scopus 로고    scopus 로고
    • RNA-triggered gene silencing
    • Fire,A. (1999) RNA-triggered gene silencing. Trends Genet., 15, 358-363.
    • (1999) Trends Genet. , vol.15 , pp. 358-363
    • Fire, A.1
  • 2
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir,S.M., Harborth,J., Lendeckel,W., Yalcin,A., Weber,K. and Tuschl,T. (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature, 411, 494-498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 3
    • 0035859046 scopus 로고    scopus 로고
    • Gene silencing as an adaptive defence against viruses
    • Waterhouse,P.M., Wang,M.B. and Lough,T. (2001) Gene silencing as an adaptive defence against viruses. Nature, 411, 834-842.
    • (2001) Nature , vol.411 , pp. 834-842
    • Waterhouse, P.M.1    Wang, M.B.2    Lough, T.3
  • 4
    • 0035281741 scopus 로고    scopus 로고
    • RNA interference-2001
    • Sharp,P.A. (2001) RNA interference-2001. Genes Dev., 15, 485-490.
    • (2001) Genes Dev. , vol.15 , pp. 485-490
    • Sharp, P.A.1
  • 5
    • 0033119713 scopus 로고    scopus 로고
    • Fast forward genetics based on virus-induced gene silencing
    • Baulcombe,D.C. (1999) Fast forward genetics based on virus-induced gene silencing. Curr. Opin. Plant Biol., 2, 109-113.
    • (1999) Curr. Opin. Plant Biol. , vol.2 , pp. 109-113
    • Baulcombe, D.C.1
  • 6
    • 0032417618 scopus 로고    scopus 로고
    • RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans
    • Montgomery,M.K., Xu,S. and Fire,A. (1998) RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA, 95, 15502-15507.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 15502-15507
    • Montgomery, M.K.1    Xu, S.2    Fire, A.3
  • 7
    • 0032443021 scopus 로고    scopus 로고
    • Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway
    • Kennerdell,J.R. and Carthew,R.W. (1998) Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway. Cell, 95, 1017-1026.
    • (1998) Cell , vol.95 , pp. 1017-1026
    • Kennerdell, J.R.1    Carthew, R.W.2
  • 8
    • 0033883114 scopus 로고    scopus 로고
    • Heritable gene silencing in Drosophila using double-stranded RNA
    • Kennerdell,J.R. and Carthew,R.W. (2000) Heritable gene silencing in Drosophila using double-stranded RNA. Nat. Biotechnol., 18, 896-898.
    • (2000) Nat. Biotechnol. , vol.18 , pp. 896-898
    • Kennerdell, J.R.1    Carthew, R.W.2
  • 9
    • 0033789992 scopus 로고    scopus 로고
    • Specific interference with gene function by double-stranded RNA in early mouse development
    • Wianny,F. and Zernicka-Goetz,M. (2000) Specific interference with gene function by double-stranded RNA in early mouse development. Nature Cell Biol., 2, 70-75.
    • (2000) Nature Cell Biol. , vol.2 , pp. 70-75
    • Wianny, F.1    Zernicka-Goetz, M.2
  • 10
    • 0037022382 scopus 로고    scopus 로고
    • Stable suppression of gene expression by RNAi in mammalian cells
    • Paddison,P.J., Caudy,A.A. and Hannon,G.J. (2002) Stable suppression of gene expression by RNAi in mammalian cells. Proc. Natl Acad. Sci. USA, 99, 1443-1448.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 1443-1448
    • Paddison, P.J.1    Caudy, A.A.2    Hannon, G.J.3
  • 11
    • 0035795428 scopus 로고    scopus 로고
    • RNA interference and small interfering RNAs
    • Tuschl,T. (2001) RNA interference and small interfering RNAs. Chembiochem., 2, 239-245.
    • (2001) Chembiochem. , vol.2 , pp. 239-245
    • Tuschl, T.1
  • 12
    • 0035694237 scopus 로고    scopus 로고
    • Identification of essential genes in cultured mammalian cells using small interfering RNAs
    • Harborth,J., Elbashir,S.M., Bechert,K., Tuschl,T. and Weber,K. (2001) Identification of essential genes in cultured mammalian cells using small interfering RNAs. J. Cell Sci., 114, 4557-4565.
    • (2001) J. Cell Sci. , vol.114 , pp. 4557-4565
    • Harborth, J.1    Elbashir, S.M.2    Bechert, K.3    Tuschl, T.4    Weber, K.5
  • 13
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein,E., Caudy,A.A., Hammond,S.M. and Hannon,G.J. (2001) Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature, 409, 363-366.
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 14
    • 17844364875 scopus 로고    scopus 로고
    • Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
    • Grishok,A., Pasquinelli,A.E., Conte,D., Li,N., Parrish,S., Ha,I., Baillie,D.L., Fire,A., Ruvkun,G. and Mello,C.C. (2001) Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell, 106, 23-34.
    • (2001) Cell , vol.106 , pp. 23-34
    • Grishok, A.1    Pasquinelli, A.E.2    Conte, D.3    Li, N.4    Parrish, S.5    Ha, I.6    Baillie, D.L.7    Fire, A.8    Ruvkun, G.9    Mello, C.C.10
  • 15
    • 0035887005 scopus 로고    scopus 로고
    • Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans
    • Ketting,R.F., Fischer,S.E., Bernstein,E., Sijen,T., Hannon,G.J. and Plasterk,R.H. (2001) Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev., 15, 2654-2659.
    • (2001) Genes Dev. , vol.15 , pp. 2654-2659
    • Ketting, R.F.1    Fischer, S.E.2    Bernstein, E.3    Sijen, T.4    Hannon, G.J.5    Plasterk, R.H.6
  • 16
    • 0035929322 scopus 로고    scopus 로고
    • A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans
    • Knight,S.W. and Bass,B.L. (2001) A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science, 293, 2269-2271.
    • (2001) Science , vol.293 , pp. 2269-2271
    • Knight, S.W.1    Bass, B.L.2
  • 18
    • 0032692170 scopus 로고    scopus 로고
    • RNA-polymerase III-driven expression cassettes in human gene therapy
    • Medina,M.F. and Joshi,S. (1999) RNA-polymerase III-driven expression cassettes in human gene therapy. Curr. Opin. Mol. Ther., 1, 580-594.
    • (1999) Curr. Opin. Mol. Ther. , vol.1 , pp. 580-594
    • Medina, M.F.1    Joshi, S.2
  • 19
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • Brummelkamp,T.R., Bernards,R. and Agami,R. (2002) A system for stable expression of short interfering RNAs in mammalian cells. Science, 296, 550-553.
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 20
    • 0037089589 scopus 로고    scopus 로고
    • Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
    • Paddison,P.J., Caudy,A.A., Bernstein,E., Hannon,G.J. and Conklin,D.S. (2002) Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev., 16, 948-958.
    • (2002) Genes Dev. , vol.16 , pp. 948-958
    • Paddison, P.J.1    Caudy, A.A.2    Bernstein, E.3    Hannon, G.J.4    Conklin, D.S.5
  • 22
    • 0037197914 scopus 로고    scopus 로고
    • RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells
    • Yu,J.Y., DeRuiter,S.L. and Turner,D.L. (2002) RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc. Natl Acad. Sci. USA, 99, 6047-6052.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 6047-6052
    • Yu, J.Y.1    DeRuiter, S.L.2    Turner, D.L.3
  • 24
    • 0036245628 scopus 로고    scopus 로고
    • U6 promoter driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells
    • Miyagishi,M. and Taira,K. (2002) U6 promoter driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells. Nat. Biotechnol., 20, 497-500.
    • (2002) Nat. Biotechnol. , vol.20 , pp. 497-500
    • Miyagishi, M.1    Taira, K.2
  • 25
    • 0036251639 scopus 로고    scopus 로고
    • Effective expression of small interfering RNA in human cells
    • Paul,C.P., Good,P.D., Winer,I. and Engelke,D.R. (2002) Effective expression of small interfering RNA in human cells. Nat. Biotechnol., 20, 505-508.
    • (2002) Nat. Biotechnol. , vol.20 , pp. 505-508
    • Paul, C.P.1    Good, P.D.2    Winer, I.3    Engelke, D.R.4
  • 26
    • 0032475878 scopus 로고    scopus 로고
    • Signaling to p53: Breaking the MDM2-p53 circuit
    • Prives,C. (1998) Signaling to p53: breaking the MDM2-p53 circuit. Cell, 95, 5-8.
    • (1998) Cell , vol.95 , pp. 5-8
    • Prives, C.1
  • 27
    • 0032191393 scopus 로고    scopus 로고
    • Tumor surveillance via the ARF-p53 pathway
    • Sherr,C.J. (1998) Tumor surveillance via the ARF-p53 pathway. Genes Dev., 12, 2984-2991.
    • (1998) Genes Dev. , vol.12 , pp. 2984-2991
    • Sherr, C.J.1
  • 28
    • 0033856462 scopus 로고    scopus 로고
    • P13-kinase inhibition: A target for drug development?
    • Stein,R.C. and Waterfield,M.D. (2000) P13-kinase inhibition: a target for drug development? Mol. Med. Today, 6, 347-357.
    • (2000) Mol. Med. Today , vol.6 , pp. 347-357
    • Stein, R.C.1    Waterfield, M.D.2
  • 29
    • 0033957661 scopus 로고    scopus 로고
    • The PTEN tumor suppressor protein: An antagonist of phosphoinositide 3-kinase signaling
    • 1470
    • Vazquez,F. and Sellers,W.R. (2000) The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling. Biochim. Biophys. Acta, 1470, M21-M35.
    • (2000) Biochim. Biophys. Acta
    • Vazquez, F.1    Sellers, W.R.2
  • 30
    • 0034820828 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinases in tumor progression
    • Roymans,D. and Slegers,H. (2001) Phosphatidylinositol 3-kinases in tumor progression. Eur. J. Biochem., 268, 487-498.
    • (2001) Eur. J. Biochem. , vol.268 , pp. 487-498
    • Roymans, D.1    Slegers, H.2
  • 31
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide, 3-kinase/AKT pathway
    • Cantley,L.C. and Neel,B.G. (1999) New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide, 3-kinase/AKT pathway. Proc. Natl Acad. Sci. USA, 96, 4240-4245.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 32
    • 0034616627 scopus 로고    scopus 로고
    • Gatekeeper for endometrium: The PTEN tumor suppressor gene
    • Ali,I.U. (2000) Gatekeeper for endometrium: the PTEN tumor suppressor gene. J. Natl Cancer Inst., 92, 861-863.
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 861-863
    • Ali, I.U.1
  • 34
    • 0028198330 scopus 로고
    • The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity
    • Klippel,A., Escobedo,J.A., Hirano,M. and Williams,L.T. (1994) The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity. Mol. Cell Biol., 14, 2675-2685.
    • (1994) Mol. Cell Biol. , vol.14 , pp. 2675-2685
    • Klippel, A.1    Escobedo, J.A.2    Hirano, M.3    Williams, L.T.4
  • 35
    • 0029883718 scopus 로고    scopus 로고
    • Role of polyadenylation in nucleocytoplasmic transport of mRNA
    • Huang,Y. and Carmichael,G.C. (1996) Role of polyadenylation in nucleocytoplasmic transport of mRNA. Mol. Cell Biol., 16, 1534-1542.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 1534-1542
    • Huang, Y.1    Carmichael, G.C.2
  • 36
    • 0032497832 scopus 로고    scopus 로고
    • Structure and function of phosphoinositide 3-kinases
    • 1436
    • Wymann,M.P. and Pirola,L. (1998) Structure and function of phosphoinositide 3-kinases. Biochim. Biophys. Acta, 1436, 127-150.
    • (1998) Biochim. Biophys. Acta , pp. 127-150
    • Wymann, M.P.1    Pirola, L.2
  • 37
    • 0032189381 scopus 로고    scopus 로고
    • Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
    • Coffer,P.J., Jin,J. and Woodgett,J.R. (1998) Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem. J., 335, 1-13.
    • (1998) Biochem. J. , vol.335 , pp. 1-13
    • Coffer, P.J.1    Jin, J.2    Woodgett, J.R.3
  • 38
    • 0034903425 scopus 로고    scopus 로고
    • Structural features in the HIV-1 repeat region facilitate strand transfer during reverse transcription
    • Berkhout,B., Vastenhouw,N.L., Klasens,B.I. and Huthoff,H. (2001) Structural features in the HIV-1 repeat region facilitate strand transfer during reverse transcription. RNA, 7, 1097-1114.
    • (2001) RNA , vol.7 , pp. 1097-1114
    • Berkhout, B.1    Vastenhouw, N.L.2    Klasens, B.I.3    Huthoff, H.4
  • 39
    • 0026738947 scopus 로고
    • Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells
    • Petersen,O.W., Ronnov-Jessen,L., Howlett,A.R. and Bissell,M.J. (1992) Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc. Natl Acad. Sci. USA, 89, 9064-9068.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 9064-9068
    • Petersen, O.W.1    Ronnov-Jessen, L.2    Howlett, A.R.3    Bissell, M.J.4
  • 40
    • 0031040331 scopus 로고    scopus 로고
    • Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties
    • Lochter,A., Srebrow,A., Sympson,C.J., Terracio,N., Werb,Z. and Bissell,M.J. (1997) Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties. J. Biol. Chem., 272, 5007-5015.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5007-5015
    • Lochter, A.1    Srebrow, A.2    Sympson, C.J.3    Terracio, N.4    Werb, Z.5    Bissell, M.J.6
  • 41
    • 0023955980 scopus 로고
    • Upstream regulatory elements are necessary and sufficient for transcription of a U6 RNA gene by RNA polymerase III
    • Das,G., Henning,D., Wright,D. and Reddy,R. (1988) Upstream regulatory elements are necessary and sufficient for transcription of a U6 RNA gene by RNA polymerase III. EMBO J., 7, 503-512.
    • (1988) EMBO J. , vol.7 , pp. 503-512
    • Das, G.1    Henning, D.2    Wright, D.3    Reddy, R.4
  • 42
    • 0036245743 scopus 로고    scopus 로고
    • Expanding small RNA interference
    • Tuschl,T. (2002) Expanding small RNA interference. Nat. Biotechnol., 20, 446-448.
    • (2002) Nat. Biotechnol. , vol.20 , pp. 446-448
    • Tuschl, T.1
  • 43
    • 0032520647 scopus 로고    scopus 로고
    • The distal elements, OCT and SPH, stimulate the formation of preinitiation complexes on a human U6 snRNA gene promoter in vitro
    • Kunkel,G.R. and Hixson,J.D. (1998) The distal elements, OCT and SPH, stimulate the formation of preinitiation complexes on a human U6 snRNA gene promoter in vitro. Nucleic Acids Res., 26, 1536-1543.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 1536-1543
    • Kunkel, G.R.1    Hixson, J.D.2
  • 44
    • 0031039644 scopus 로고    scopus 로고
    • In vivo selection of RNAs that localize in the nucleus
    • Grimm,C., Lund,E. and Dahlberg,J.E. (1997) In vivo selection of RNAs that localize in the nucleus. EMBO J., 16, 793-806.
    • (1997) EMBO J. , vol.16 , pp. 793-806
    • Grimm, C.1    Lund, E.2    Dahlberg, J.E.3
  • 45
    • 0035807818 scopus 로고    scopus 로고
    • Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines
    • Billy,E., Brondani,V., Zhang,H., Muller,U. and Filipowicz,W. (2001) Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines. Proc. Natl Acad. Sci. USA, 98, 14428-14433.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 14428-14433
    • Billy, E.1    Brondani, V.2    Zhang, H.3    Muller, U.4    Filipowicz, W.5
  • 49
    • 0029973135 scopus 로고    scopus 로고
    • Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes
    • Martin,S.S., Haruta,T., Morris,A.J., Klippel,A., Williams,L.T. and Olefsky,J.M. (1996) Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes. J. Biol. Chem., 271, 17605-17608.
    • (1996) J. Biol. Chem. , vol.271 , pp. 17605-17608
    • Martin, S.S.1    Haruta, T.2    Morris, A.J.3    Klippel, A.4    Williams, L.T.5    Olefsky, J.M.6
  • 50
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22-nucleotide RNAs
    • Elbashir,S.M., Lendeckel,W. and Tuschl,T. (2001) RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev., 15, 188-200.
    • (2001) Genes Dev. , vol.15 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 52
    • 0031456065 scopus 로고    scopus 로고
    • Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion
    • Shaw,L.M., Rabinovitz,I., Wang,H.H., Toker,A. and Mercurio,A.M. (1997) Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion. Cell, 91, 949-960.
    • (1997) Cell , vol.91 , pp. 949-960
    • Shaw, L.M.1    Rabinovitz, I.2    Wang, H.H.3    Toker, A.4    Mercurio, A.M.5
  • 53
    • 0031708412 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation
    • Klippel,A., Escobedo,M.A., Wachowicz,M.S., Apell,G., Brown,T.W., Giedlin,M.A., Kavanaugh,W.M. and Williams,L.T. (1998) Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation. Mol. Cell, Biol., 18, 5699-5711,
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 5699-5711
    • Klippel, A.1    Escobedo, M.A.2    Wachowicz, M.S.3    Apell, G.4    Brown, T.W.5    Giedlin, M.A.6    Kavanaugh, W.M.7    Williams, L.T.8
  • 54
    • 0034052609 scopus 로고    scopus 로고
    • Control of the functional activity of an antisense RNA by a tetracycline-responsive derivative of the human U6 snRNA promoter
    • Ohkawa,J. and Taira,K. (2000) Control of the functional activity of an antisense RNA by a tetracycline-responsive derivative of the human U6 snRNA promoter. Hum. Gene Ther., 11, 577-585.
    • (2000) Hum. Gene Ther. , vol.11 , pp. 577-585
    • Ohkawa, J.1    Taira, K.2


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