-
1
-
-
0032497832
-
Structure and function of phosphoinositide 3-kinases
-
&
-
Wymann, M.P. & L. Pirola. 1998. Structure and function of phosphoinositide 3-kinases. Biochim. Biophys. Acta 1436 : 127 150.
-
(1998)
Biochim. Biophys. Acta
, vol.1436
, pp. 127-150
-
-
Wymann, M.P.1
Pirola, L.2
-
2
-
-
0028850053
-
Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase
-
&
-
Royal, I. & M. Park. 1995. Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase. J. Biol. Chem. 270 : 27780 27787.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 27780-27787
-
-
Royal, I.1
Park, M.2
-
3
-
-
0033747214
-
Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways
-
Attoub, S., V. Noe, L. Pirola, et al. 2000. Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways. Faseb J. 14 : 2329 2338.
-
(2000)
Faseb J.
, vol.14
, pp. 2329-2338
-
-
Attoub, S.1
Noe, V.2
Pirola, L.3
-
4
-
-
0033912699
-
The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase
-
Genot, E.M., C. Arrieumerlou, G. Ku, et al. 2000. The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase. Mol. Cell. Biol. 20 : 5469 5478.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 5469-5478
-
-
Genot, E.M.1
Arrieumerlou, C.2
Ku, G.3
-
5
-
-
0029990003
-
Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation
-
Rodriguez-Viciana, P., P.H. Warne, B. Vanhaesebroeck, et al. 1996. Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. EMBO J. 15 : 2442 2451.
-
(1996)
EMBO J.
, vol.15
, pp. 2442-2451
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Vanhaesebroeck, B.3
-
6
-
-
0029160069
-
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
-
&
-
Burgering, B.M. & P.J. Coffer. 1995. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376 : 599 602.
-
(1995)
Nature
, vol.376
, pp. 599-602
-
-
Burgering, B.M.1
Coffer, P.J.2
-
8
-
-
0030992837
-
Signalling through the lipid products of phosphoinositide-3-OH kinase
-
&
-
Toker, A. & L.C. Cantley. 1997. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387 : 673 676.
-
(1997)
Nature
, vol.387
, pp. 673-676
-
-
Toker, A.1
Cantley, L.C.2
-
9
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels, Y., Z. Wang, A. Bardelli, et al. 2004. High frequency of mutations of the PIK3CA gene in human cancers. Science 304 : 554.
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
-
10
-
-
0035886016
-
The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors
-
Philp, A.J., I.G. Campbell, C. Leet, et al. 2001. The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors. Cancer Res. 61 : 7426 7429.
-
(2001)
Cancer Res.
, vol.61
, pp. 7426-7429
-
-
Philp, A.J.1
Campbell, I.G.2
Leet, C.3
-
11
-
-
0034687278
-
A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells
-
&
-
Benistant, C., H. Chapuis & S. Roche. 2000. A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells. Oncogene 19 : 5083 5090.
-
(2000)
Oncogene
, vol.19
, pp. 5083-5090
-
-
Benistant, C.1
Chapuis, H.2
Roche, S.3
-
12
-
-
7344258310
-
Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3′-kinase is a critical mediator of tumor invasion
-
Kotelevets, L., V. Noe, E. Bruyneel, et al. 1998. Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3′-kinase is a critical mediator of tumor invasion. J. Biol. Chem. 273 : 14138 14145.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14138-14145
-
-
Kotelevets, L.1
Noe, V.2
Bruyneel, E.3
-
13
-
-
0029090212
-
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
-
Stoyanov, B., S. Volinia, T. Hanck, et al. 1995. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science 269 : 690 693.
-
(1995)
Science
, vol.269
, pp. 690-693
-
-
Stoyanov, B.1
Volinia, S.2
Hanck, T.3
-
14
-
-
0030887632
-
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101
-
Stephens, L.R., A. Eguinoa, H. Erdjument-Bromage, et al. 1997. The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell 89 : 105 114.
-
(1997)
Cell
, vol.89
, pp. 105-114
-
-
Stephens, L.R.1
Eguinoa, A.2
Erdjument-Bromage, H.3
-
15
-
-
0032500730
-
Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK
-
Bondeva, T., L. Pirola, G. Bulgarelli-Leva, et al. 1998. Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK. Science 282 : 293 296.
-
(1998)
Science
, vol.282
, pp. 293-296
-
-
Bondeva, T.1
Pirola, L.2
Bulgarelli-Leva, G.3
-
16
-
-
0032579244
-
Phosphoinositide 3-kinase gamma is a mediator of Gbetagamma-dependent Jun kinase activation
-
&
-
Lopez-Ilasaca, M., J.S. Gutkind & R. Wetzker. 1998. Phosphoinositide 3-kinase gamma is a mediator of Gbetagamma-dependent Jun kinase activation. J. Biol. Chem. 273 : 2505 2508.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 2505-2508
-
-
Lopez-Ilasaca, M.1
Gutkind, J.S.2
Wetzker, R.3
-
17
-
-
0031037296
-
Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma
-
Lopez-Ilasaca, M., P. Crespo, P.G. Pellici, et al. 1997. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma. Science 275 : 394 397.
-
(1997)
Science
, vol.275
, pp. 394-397
-
-
Lopez-Ilasaca, M.1
Crespo, P.2
Pellici, P.G.3
-
18
-
-
0035847014
-
Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma/Janus kinase 2/MEK-1-dependent pathway
-
&
-
Cieslik, K., C.S. Abrams & K.K. Wu. 2001. Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma/Janus kinase 2/MEK-1-dependent pathway. J. Biol. Chem. 276 : 1211 1219.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 1211-1219
-
-
Cieslik, K.1
Abrams, C.S.2
Wu, K.K.3
-
19
-
-
0030920653
-
Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase gamma: Structure-activity analysis and interactions with wortmannin
-
Stoyanova, S., G. Bulgarelli-Leva, C. Kirsch, et al. 1997. Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase gamma: structure-activity analysis and interactions with wortmannin. Biochem. J. 324 (Pt 2 489 495.
-
(1997)
Biochem. J.
, vol.324
, Issue.2
, pp. 489-495
-
-
Stoyanova, S.1
Bulgarelli-Leva, G.2
Kirsch, C.3
-
20
-
-
0032853715
-
Phospatidylinositol 3-kinase expression in human breast cancer
-
Gershtein, E.S., V.A. Shatskaya, V.D. Ermilova, et al. 1999. Phospatidylinositol 3-kinase expression in human breast cancer. Clin. Chim. Acta. 287 : 59 67.
-
(1999)
Clin. Chim. Acta.
, vol.287
, pp. 59-67
-
-
Gershtein, E.S.1
Shatskaya, V.A.2
Ermilova, V.D.3
-
21
-
-
0036729867
-
Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy
-
&
-
Krystal, G.W., G. Sulanke & J. Litz. 2002. Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy. Mol. Cancer Ther. 913 922.
-
(2002)
Mol. Cancer Ther.
, pp. 913-922
-
-
Krystal, G.W.1
Sulanke, G.2
Litz, J.3
-
22
-
-
0035950131
-
Weakening link to colorectal cancer?
-
Barbier, M., S. Attoub, R. Calvez, et al. 2001. Weakening link to colorectal cancer? Nature 413 : 796.
-
(2001)
Nature
, vol.413
, pp. 796
-
-
Barbier, M.1
Attoub, S.2
Calvez, R.3
-
23
-
-
31944448780
-
Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase
-
Kang, S., A. Denley, B. Vanhaesebroeck, et al. 2006. Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase. PNAS 103 : 1289 1294.
-
(2006)
PNAS
, vol.103
, pp. 1289-1294
-
-
Kang, S.1
Denley, A.2
Vanhaesebroeck, B.3
-
24
-
-
33746537715
-
Phosphatidylinositol 3-kinase gamma mediates shear stress-dependent activation of JNK in endothelial cells
-
Go, Y.M., H. Park, M.C. Maland, et al. 1998. Phosphatidylinositol 3-kinase gamma mediates shear stress-dependent activation of JNK in endothelial cells. Am. J. Physiol. 275 (5 Pt 2 H1898 H1904.
-
(1998)
Am. J. Physiol.
, vol.275
, Issue.52
-
-
Go, Y.M.1
Park, H.2
Maland, M.C.3
-
25
-
-
0034332904
-
Leukocytes navigate by compass: Roles of PI3Kgamma and its lipid products
-
Rickert, P., O.D. Weiner, F. Wang, et al. 2000. Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products. Trends Cell Biol. 10 : 466 473.
-
(2000)
Trends Cell Biol.
, vol.10
, pp. 466-473
-
-
Rickert, P.1
Weiner, O.D.2
Wang, F.3
-
26
-
-
15144353776
-
Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
-
Han, J., K. Luby-Phelps, B. Das, et al. 1998. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 279 : 558 560.
-
(1998)
Science
, vol.279
, pp. 558-560
-
-
Han, J.1
Luby-Phelps, K.2
Das, B.3
-
27
-
-
0033610835
-
A novel mitogenic signaling pathway of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, phosphatidylinositol 3-kinase beta, and protein kinase Cepsilon
-
Graness, A., A. Adomeit, R. Heinze, et al. 1998. A novel mitogenic signaling pathway of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, phosphatidylinositol 3-kinase beta, and protein kinase Cepsilon. J. Biol. Chem. 273 : 32016 32022.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 32016-32022
-
-
Graness, A.1
Adomeit, A.2
Heinze, R.3
-
28
-
-
0036898614
-
Down-regulation of PIK3CG, a catalytic subunit of phosphatidylinositol 3-OH kinase, by CpG hypermethylation in human colorectal carcinoma
-
Semba, S., N. Itoh, M. Ito, et al. 2002. Down-regulation of PIK3CG, a catalytic subunit of phosphatidylinositol 3-OH kinase, by CpG hypermethylation in human colorectal carcinoma. Clin. Cancer Res. 8 : 3824 3831.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 3824-3831
-
-
Semba, S.1
Itoh, N.2
Ito, M.3
-
29
-
-
0033980552
-
Internalization of the E-cadherin/catenin complex and scattering of human mammary carcinoma cells MCF-7/AZ after treatment with conditioned medium from human skin squamous carcinoma cells COLO 16
-
Boterberg, T., K.M. Vennekens, M. Thienpont, et al. 2000. Internalization of the E-cadherin/catenin complex and scattering of human mammary carcinoma cells MCF-7/AZ after treatment with conditioned medium from human skin squamous carcinoma cells COLO 16. Cell Adhes. Commun. 7 : 299 310.
-
(2000)
Cell Adhes. Commun.
, vol.7
, pp. 299-310
-
-
Boterberg, T.1
Vennekens, K.M.2
Thienpont, M.3
-
30
-
-
34247869640
-
The recruitment of phosphatidylinositol 3-kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and human keratinocyte differentiation
-
&
-
Xie, Z. & D.D. Bikle. 2007. The recruitment of phosphatidylinositol 3-kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and human keratinocyte differentiation. J. Biol. Chem. 282 : 8695 8703.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 8695-8703
-
-
Xie, Z.1
Bikle, D.D.2
-
31
-
-
35448938870
-
Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase γ
-
Costa, C., L. Barberis, C. Ambrogio, et al. 2007. Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase γ. PNAS 104 : 14354 14359.
-
(2007)
PNAS
, vol.104
, pp. 14354-14359
-
-
Costa, C.1
Barberis, L.2
Ambrogio, C.3
-
32
-
-
18344370242
-
Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells
-
Lee, H.Y., G.U. Bae, I.D. Jung, et al. 2002. Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells. FEBS Letters 515 : 137 140.
-
(2002)
FEBS Letters
, vol.515
, pp. 137-140
-
-
Lee, H.Y.1
Bae, G.U.2
Jung, I.D.3
-
33
-
-
0035128299
-
Induction of scattering and cellular invasion by trefoil peptides in src- and RhoA-transformed kidney and colonic epithelial cells
-
Emami, S., F. Le, N. loch, E. Bruyneel, et al. 2001. Induction of scattering and cellular invasion by trefoil peptides in src- and RhoA-transformed kidney and colonic epithelial cells. FASEB J. 15 : 351 361.
-
(2001)
FASEB J.
, vol.15
, pp. 351-361
-
-
Emami, S.1
Le, F.2
Loch, N.3
Bruyneel, E.4
-
34
-
-
2642522719
-
Trefoil factors family (TFFs) peptides and cancer progression
-
Emami, S., S. Rodrigues, C.M. Rodrigue, et al. 2004. Trefoil factors family (TFFs) peptides and cancer progression. PEPTIDES 25 : 885 898.
-
(2004)
PEPTIDES
, vol.25
, pp. 885-898
-
-
Emami, S.1
Rodrigues, S.2
Rodrigue, C.M.3
-
35
-
-
36549042103
-
Adipokines as emerging mediators of immune response and inflammation
-
Lago, F., C. Dieguez, J. Gómez-Reino, et al. 2007. Adipokines as emerging mediators of immune response and inflammation. Nat. Clin. Pract. Rheumatol. 716 724.
-
(2007)
Nat. Clin. Pract. Rheumatol.
, pp. 716-724
-
-
Lago, F.1
Dieguez, C.2
Gómez-Reino, J.3
-
36
-
-
32844467885
-
Commutators of PAR-1 signaling in cancer cell invasion reveal an essential role of the Rho-Rho kinase axis and tumor microenvironment
-
Nguyen, Q.D., O. De Wever, E. Bruyneel, et al. 2005. Commutators of PAR-1 signaling in cancer cell invasion reveal an essential role of the Rho-Rho kinase axis and tumor microenvironment. Oncogene 24 : 8240 8251.
-
(2005)
Oncogene
, vol.24
, pp. 8240-8251
-
-
Nguyen, Q.D.1
De Wever, O.2
Bruyneel, E.3
-
39
-
-
33747134769
-
Electrical signals control wound healing through phosphatidylinositol-3- OH kinase-gamma and PTEN
-
Zhao, M., B. Song, J. Pu, T. Wada, et al. 2006. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature 442 : 457 460.
-
(2006)
Nature
, vol.442
, pp. 457-460
-
-
Zhao, M.1
Song, B.2
Pu, J.3
Wada, T.4
-
40
-
-
33646370512
-
BCR-ABL regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation and is required for proliferation and drug resistance
-
&
-
Hickey, F.B. & T.G. Cotter. 2006. BCR-ABL regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation and is required for proliferation and drug resistance. J Biol. Chem. 281 : 2441 2450.
-
(2006)
J Biol. Chem.
, vol.281
, pp. 2441-2450
-
-
Hickey, F.B.1
Cotter, T.G.2
-
41
-
-
33744518663
-
Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B
-
Voigt, P., M.B. Dorner, M. Schaefer. 2006. Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B. JBC 281 : 9977 9986.
-
(2006)
JBC
, vol.281
, pp. 9977-9986
-
-
Voigt, P.1
Dorner, M.B.2
Schaefer, M.3
-
42
-
-
0029090212
-
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
-
Stoyanov, B., S. Volinia, T. Hanck, et al. 1995. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science 269 : 690 693.
-
(1995)
Science
, vol.269
, pp. 690-693
-
-
Stoyanov, B.1
Volinia, S.2
Hanck, T.3
-
43
-
-
35148839928
-
PI3Kgamma is a key regulator of inflammatory responses and cardiovascular homeostasis
-
&
-
Hawkins, P.T. & L.R. Stephens. 2007. PI3Kgamma is a key regulator of inflammatory responses and cardiovascular homeostasis. Science 318 : 64 66.
-
(2007)
Science
, vol.318
, pp. 64-66
-
-
Hawkins, P.T.1
Stephens, L.R.2
|