메뉴 건너뛰기




Volumn 130, Issue 11, 2012, Pages 2505-2513

PI3K class IB controls the cell cycle checkpoint promoting cell proliferation in hepatocellular carcinoma

Author keywords

phosphatidylinositol 3,4,5 trisphosphate; proliferation; signal pathways; tumor progression

Indexed keywords

KI 67 ANTIGEN; P110GAMMA PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P21; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

EID: 84859156758     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.26319     Document Type: Article
Times cited : (37)

References (25)
  • 1
    • 1942466512 scopus 로고    scopus 로고
    • Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity
    • Apr 15;.
    • Wang GL, Iakova P, Wilde M, Awad S, Timchenko NA,. Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. Genes Dev 2004 Apr 15; 18 (8): 912-25.
    • (2004) Genes Dev , vol.18 , Issue.8 , pp. 912-925
    • Wang, G.L.1    Iakova, P.2    Wilde, M.3    Awad, S.4    Timchenko, N.A.5
  • 2
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • Aug;.
    • Engelman JA, Luo J, Cantley LC,. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006 Aug; 7 (8): 606-19.
    • (2006) Nat Rev Genet , vol.7 , Issue.8 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 3
    • 53049087511 scopus 로고    scopus 로고
    • Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells
    • Aug 15;.
    • Chen KF, Yeh PY, Yeh KH, Lu YS, Huang SY, Cheng AL,. Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells. Cancer Res 2008 Aug 15; 68 (16): 6698-707.
    • (2008) Cancer Res , vol.68 , Issue.16 , pp. 6698-6707
    • Chen, K.F.1    Yeh, P.Y.2    Yeh, K.H.3    Lu, Y.S.4    Huang, S.Y.5    Cheng, A.L.6
  • 4
    • 63749088064 scopus 로고    scopus 로고
    • Dysregulation of apoptosis in hepatocellular carcinoma cells
    • Feb 7;.
    • Fabregat I,. Dysregulation of apoptosis in hepatocellular carcinoma cells. World J Gastroenterol 2009 Feb 7; 15 (5): 513-20.
    • (2009) World J Gastroenterol , vol.15 , Issue.5 , pp. 513-520
    • Fabregat, I.1
  • 5
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • May 31;.
    • Cantley LC,. The phosphoinositide 3-kinase pathway. Science 2002 May 31; 296 (5573): 1655-7.
    • (2002) Science , vol.296 , Issue.5573 , pp. 1655-1657
    • Cantley, L.C.1
  • 9
    • 62849114529 scopus 로고    scopus 로고
    • Regulation of phosphoinositide 3-kinase expression in health and disease
    • Mar;.
    • Kok K, Geering B, Vanhaesebroeck B,. Regulation of phosphoinositide 3-kinase expression in health and disease. Trends Biochem Sci 2009 Mar; 34 (3): 115-27.
    • (2009) Trends Biochem Sci , vol.34 , Issue.3 , pp. 115-127
    • Kok, K.1    Geering, B.2    Vanhaesebroeck, B.3
  • 11
    • 13944284494 scopus 로고    scopus 로고
    • Oncogenic mutations of PIK3CA in human cancers
    • Oct;.
    • Samuels Y, Velculescu VE,. Oncogenic mutations of PIK3CA in human cancers. Cell Cycle 2004 Oct; 3 (10): 1221-4.
    • (2004) Cell Cycle , vol.3 , Issue.10 , pp. 1221-1224
    • Samuels, Y.1    Velculescu, V.E.2
  • 12
    • 25444482837 scopus 로고    scopus 로고
    • Mutated PI 3-kinases: Cancer targets on a silver platter
    • Apr;.
    • Kang S, Bader AG, Zhao L, Vogt PK,. Mutated PI 3-kinases: cancer targets on a silver platter. Cell Cycle 2005 Apr; 4 (4): 578-81.
    • (2005) Cell Cycle , vol.4 , Issue.4 , pp. 578-581
    • Kang, S.1    Bader, A.G.2    Zhao, L.3    Vogt, P.K.4
  • 14
    • 0034687278 scopus 로고    scopus 로고
    • A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells
    • Oct 19;.
    • Benistant C, Chapuis H, Roche S,. A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells. Oncogene 2000 Oct 19; 19 (44): 5083-90.
    • (2000) Oncogene , vol.19 , Issue.44 , pp. 5083-5090
    • Benistant, C.1    Chapuis, H.2    Roche, S.3
  • 15
    • 0242499482 scopus 로고    scopus 로고
    • Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3′-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas
    • Oct;.
    • Knobbe CB, Reifenberger G,. Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3′-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas. Brain Pathol 2003 Oct; 13 (4): 507-18.
    • (2003) Brain Pathol , vol.13 , Issue.4 , pp. 507-518
    • Knobbe, C.B.1    Reifenberger, G.2
  • 17
    • 0035044816 scopus 로고    scopus 로고
    • Human Hepatocellular Carcinoma (HCC) Cells Require Both alpha3beta1 Integrin and Matrix Metalloproteinases Activity for Migration and Invasion
    • Apr;.
    • Giannelli G, Bergamini C, Fransvea E, Marinosci F, Quaranta V, Antonaci S,. Human Hepatocellular Carcinoma (HCC) Cells Require Both alpha3beta1 Integrin and Matrix Metalloproteinases Activity for Migration and Invasion. Lab Invest 2001 Apr; 81 (4): 613-27.
    • (2001) Lab Invest , vol.81 , Issue.4 , pp. 613-627
    • Giannelli, G.1    Bergamini, C.2    Fransvea, E.3    Marinosci, F.4    Quaranta, V.5    Antonaci, S.6
  • 18
    • 27744527762 scopus 로고    scopus 로고
    • Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma
    • Giannelli G, Bergamini C, Fransvea E, Sgarra C, Antonaci S,. Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma. Gastroenterology 2005; 129: 1375-83.
    • (2005) Gastroenterology , vol.129 , pp. 1375-1383
    • Giannelli, G.1    Bergamini, C.2    Fransvea, E.3    Sgarra, C.4    Antonaci, S.5
  • 20
    • 52149112086 scopus 로고    scopus 로고
    • Activation of the cyclin D2 and cdk6 genes through NF-kappaB is critical for cell-cycle progression induced by HTLV-I Tax
    • Sep 18;.
    • Iwanaga R, Ozono E, Fujisawa J, Ikeda MA, Okamura N, Huang Y, Ohtani K,. Activation of the cyclin D2 and cdk6 genes through NF-kappaB is critical for cell-cycle progression induced by HTLV-I Tax. Oncogene 2008 Sep 18; 27 (42): 5635-42.
    • (2008) Oncogene , vol.27 , Issue.42 , pp. 5635-5642
    • Iwanaga, R.1    Ozono, E.2    Fujisawa, J.3    Ikeda, M.A.4    Okamura, N.5    Huang, Y.6    Ohtani, K.7
  • 21
    • 31944448780 scopus 로고    scopus 로고
    • Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class i phospho-inositide 3-kinase
    • Jan 31;.
    • Kang S, Denley A, Vanhaesebroeck B, Vogt PK,. Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phospho-inositide 3-kinase. Proc Natl Acad Sci U S A. 2006 Jan 31; 103 (5): 1289-94.
    • (2006) Proc Natl Acad Sci U S A. , vol.103 , Issue.5 , pp. 1289-1294
    • Kang, S.1    Denley, A.2    Vanhaesebroeck, B.3    Vogt, P.K.4
  • 24
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Jun 29;.
    • Manning BD, Cantley LC,. AKT/PKB signaling: navigating downstream. Cell 2007 Jun 29; 129 (7): 1261-74.
    • (2007) Cell , vol.129 , Issue.7 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.