-
4
-
-
0036883940
-
Pancreatic cancer biology and genetics
-
Bardeesy N, DePinho RA. Pancreatic cancer biology and genetics. Nat Rev Cancer. 2002;12:897-909.
-
(2002)
Nat Rev Cancer
, vol.12
, pp. 897-909
-
-
Bardeesy, N.1
DePinho, R.A.2
-
5
-
-
0024292722
-
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras gene
-
Almoguera C, Shibata D, Forrester K, et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras gene. Cell. 1998;53:549-554.
-
(1998)
Cell
, vol.53
, pp. 549-554
-
-
Almoguera, C.1
Shibata, D.2
Forrester, K.3
-
6
-
-
0026334753
-
Abnormalities of the p53 tumor suppressor gene in human pancreatic cancer
-
Barton CM, Staddon SL, Hughes CM, et al. Abnormalities of the p53 tumor suppressor gene in human pancreatic cancer. Br J Cancer. 1991; 64:1076-1082.
-
(1991)
Br J Cancer
, vol.64
, pp. 1076-1082
-
-
Barton, C.M.1
Staddon, S.L.2
Hughes, C.M.3
-
7
-
-
0036259301
-
Suppression of the tumorigeni phenotype by chromosome 18 transfer into pancreatic cancer cell lines
-
Lefter LP, Furukawa T, Sunamura M, et al. Suppression of the tumorigeni phenotype by chromosome 18 transfer into pancreatic cancer cell lines. Genes Chromosomes Cancer. 2002;27:234-242.
-
(2002)
Genes Chromosomes Cancer
, vol.27
, pp. 234-242
-
-
Lefter, L.P.1
Furukawa, T.2
Sunamura, M.3
-
9
-
-
0034051974
-
Identification of frequent chromosome aberrations in ductal adenocarcinoma of the pancreas by comparative genomic hybridization (CGH)
-
Schleger C, Arens N, Zentgraf H, et al. Identification of frequent chromosome aberrations in ductal adenocarcinoma of the pancreas by comparative genomic hybridization (CGH). J Pathol. 2000;191:27-32.
-
(2000)
J Pathol
, vol.191
, pp. 27-32
-
-
Schleger, C.1
Arens, N.2
Zentgraf, H.3
-
10
-
-
0031047115
-
Molecular pathology of primary and metastatic ductal pancreatic lesions: Analyses of mutations and expression of the p53, mdm-2, and p21/WAF-1 genes in sporadic and familial lesion
-
Bruce AR, Lingyi H, Berger D, et al. Molecular pathology of primary and metastatic ductal pancreatic lesions: analyses of mutations and expression of the p53, mdm-2, and p21/WAF-1 genes in sporadic and familial lesion. Cancer. 1997;79:700-716.
-
(1997)
Cancer
, vol.79
, pp. 700-716
-
-
Bruce, A.R.1
Lingyi, H.2
Berger, D.3
-
11
-
-
0030907987
-
PI3K: Downstream AKTion blocks apoptosis
-
Franke TF, Kaplan DR, Cantley LC. PI3K: downstream AKTion blocks apoptosis. Cell. 1997;88:435-437.
-
(1997)
Cell
, vol.88
, pp. 435-437
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
-
12
-
-
0029160069
-
Protein kinaseB (c-Akt) in phosphatidylinositol -3-OH kinase signal transduction
-
Boudewiji MT, Coffer PJ. Protein kinaseB (c-Akt) in phosphatidylinositol -3-OH kinase signal transduction. Nature. 1995;376:599-602.
-
(1995)
Nature
, vol.376
, pp. 599-602
-
-
Boudewiji, M.T.1
Coffer, P.J.2
-
13
-
-
0029079275
-
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
-
Franke TF, Yang S, Chan TO, et al. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell. 1995;81:727-736.
-
(1995)
Cell
, vol.81
, pp. 727-736
-
-
Franke, T.F.1
Yang, S.2
Chan, T.O.3
-
14
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta SR, Dudek H, Tao X, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 1997;91:231-241.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
-
15
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
Cardone MH, Roy N, Stennicke HR, et al. Regulation of cell death protease caspase-9 by phosphorylation. Science. 1998;282:1318-1321.
-
(1998)
Science
, vol.282
, pp. 1318-1321
-
-
Cardone, M.H.1
Roy, N.2
Stennicke, H.R.3
-
16
-
-
0037380304
-
Phosphorylated Akt/PKB controls cell growth and apoptosis in intraductal papillary-mucinous tumor and invasive ductal adenocarcinoma of the pancreas
-
Semba S, Moriya T, Kimura W, et al. Phosphorylated Akt/PKB controls cell growth and apoptosis in intraductal papillary-mucinous tumor and invasive ductal adenocarcinoma of the pancreas. Pancreas. 2003;26:250-257.
-
(2003)
Pancreas
, vol.26
, pp. 250-257
-
-
Semba, S.1
Moriya, T.2
Kimura, W.3
-
18
-
-
0036176126
-
Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: Requirement for Akt activation
-
Del Bufalo D, Di Castro V, Biroccio A, et al. Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for Akt activation. Mol Pharmacol. 2002;61:524-532.
-
(2002)
Mol Pharmacol
, vol.61
, pp. 524-532
-
-
Del Bufalo, D.1
Di Castro, V.2
Biroccio, A.3
-
19
-
-
0030666921
-
Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase
-
Duforny B, Alblas J, Teeffelen HA, et al. Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase. J Biol Chem. 1997;272:31163-31171.
-
(1997)
J Biol Chem
, vol.272
, pp. 31163-31171
-
-
Duforny, B.1
Alblas, J.2
Teeffelen, H.A.3
-
20
-
-
0029794614
-
Rapamycin inhibits constitutive p70s6k phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells
-
Seufferlein T, Rozengurt E. Rapamycin inhibits constitutive p70s6k phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells. Cancer Res. 1996;56:3895-3897.
-
(1996)
Cancer Res
, vol.56
, pp. 3895-3897
-
-
Seufferlein, T.1
Rozengurt, E.2
-
21
-
-
0029810181
-
Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation
-
Kohn AD, Takeuchi F, Roth RA. Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation. J Biol Chem. 1996;271:21920-21926.
-
(1996)
J Biol Chem
, vol.271
, pp. 21920-21926
-
-
Kohn, A.D.1
Takeuchi, F.2
Roth, R.A.3
-
22
-
-
0030847535
-
PtdIns (3,4,5) P3 gets its message across
-
Hemming BA. PtdIns (3,4,5) P3 gets its message across. Science. 1997; 277:534.
-
(1997)
Science
, vol.277
, pp. 534
-
-
Hemming, B.A.1
-
23
-
-
0028170210
-
A apecific 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
-
Vlahos CJ, Matter WF, Hui KY, et al. A apecific 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem. 1994;269: 5241-5248.
-
(1994)
J Biol Chem
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
-
24
-
-
0031045634
-
Expression of Fas antigen and its mediation of apoptosis in human gastric cancer cell lines
-
Hayashi H, Tatebe S, Osaki M, et al. Expression of Fas antigen and its mediation of apoptosis in human gastric cancer cell lines. Jpn J Cancer Res. 1997;88:49-55.
-
(1997)
Jpn J Cancer Res
, vol.88
, pp. 49-55
-
-
Hayashi, H.1
Tatebe, S.2
Osaki, M.3
-
25
-
-
0041338049
-
Inhibition of the phosphatidylinositol 3′-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo
-
Bondar VM, Sweeney-Gotsch B, Andreeff M, et al. Inhibition of the phosphatidylinositol 3′-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo. Mol Cancer Ther. 2002;1:989-997.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 989-997
-
-
Bondar, V.M.1
Sweeney-Gotsch, B.2
Andreeff, M.3
-
26
-
-
0033304945
-
The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation
-
Pestell RG, Albanese C, Reutens AT, et al. The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation. Endocrine. 1999;20:501-534.
-
(1999)
Endocrine
, vol.20
, pp. 501-534
-
-
Pestell, R.G.1
Albanese, C.2
Reutens, A.T.3
-
27
-
-
0033564697
-
CDK inhibitors: Positive and negative regulators of G1 phase progression
-
Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1 phase progression. Genes Dev. 1999;13:1501-1512.
-
(1999)
Genes Dev
, vol.13
, pp. 1501-1512
-
-
Sherr, C.J.1
Roberts, J.M.2
-
28
-
-
18644370396
-
Kip1 by PKB/Akt-mediated phosphorylation in breast cancer
-
Kip1 by PKB/Akt-mediated phosphorylation in breast cancer. Nat Med. 2002;8:1136-1144.
-
(2002)
Nat Med
, vol.8
, pp. 1136-1144
-
-
Viglietto, G.1
Motti, M.L.2
Buuni, P.3
-
29
-
-
0029670477
-
Translational control of p27/Kip1 accumulation during the cell cycle
-
Hengst L, Reed SI. Translational control of p27/Kip1 accumulation during the cell cycle. Science. 1996;271:1861-1864.
-
(1996)
Science
, vol.271
, pp. 1861-1864
-
-
Hengst, L.1
Reed, S.I.2
-
30
-
-
0029024015
-
Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
-
Pagano M, Tam SW, Theodoras AM, et al. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science. 1995;269:682-685.
-
(1995)
Science
, vol.269
, pp. 682-685
-
-
Pagano, M.1
Tam, S.W.2
Theodoras, A.M.3
-
31
-
-
0038583881
-
Protein-protein interactions involved in the recognition of p27 by E3 ubiquitin ligase
-
Xu K, Belunis C, Chu W, et al. Protein-protein interactions involved in the recognition of p27 by E3 ubiquitin ligase. Biochem J. 2003;371:957-964.
-
(2003)
Biochem J
, vol.371
, pp. 957-964
-
-
Xu, K.1
Belunis, C.2
Chu, W.3
-
32
-
-
0037325853
-
Deregulated degradation of the cdk inhibitor p27 and malignant transformation
-
Bloom J, Pagano M. Deregulated degradation of the cdk inhibitor p27 and malignant transformation. Cancer Biol. 2003;13:41-47.
-
(2003)
Cancer Biol
, vol.13
, pp. 41-47
-
-
Bloom, J.1
Pagano, M.2
-
33
-
-
0037047268
-
Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization
-
Fujita N, Sata N, Katayama K, et al. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. J Biol Chem. 2002;277:28706-28713.
-
(2002)
J Biol Chem
, vol.277
, pp. 28706-28713
-
-
Fujita, N.1
Sata, N.2
Katayama, K.3
|