Identification of upregulated phosphoinositide 3-kinase γ as a target to suppress breast cancer cell migration and invasion

Biochemical Pharmacology

Volumn 85, Issue 10, 2013, Pages 1454-1462

  Xie, Yan ^a   Abel, Peter W ^a   Kirui, Joseph K ^a   Deng, Caishu ^a   Sharma, Poonam ^a   Wolff, Dennis W ^a   Toews, Myron L ^b   Tu, Yaping ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Breast cancer; Lamellipodia; Metastasis; Migration and invasion; PI3K

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR TYROSINE KINASE RECEPTOR; G PROTEIN COUPLED RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE BETA; PHOSPHATIDYLINOSITOL 3 KINASE DELTA; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEINASE ACTIVATED RECEPTOR 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; BREAST METASTASIS; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; FEMALE; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LAMELLIPODIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

BREAST NEOPLASMS; CARCINOMA, DUCTAL; CELL LINE, TUMOR; CELL MOVEMENT; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; DIFFUSION CHAMBERS, CULTURE; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM INVASIVENESS; PROTEIN KINASE INHIBITORS; PSEUDOPODIA; RECEPTOR, PAR-1; RECEPTORS, CXCR4; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84876679729     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.03.001     Document Type: Article

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