Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation

Neuron

Volumn 84, Issue 2, 2014, Pages 292-309

  Maday, Sandra ^a   Twelvetrees, Alison E ^a   Moughamian, Armen J ^a   Holzbaur, Erika L F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; ARL8 PROTEIN; CALCIUM; CELL PROTEIN; DYNEIN ADENOSINE TRIPHOSPHATASE; HUNTINGTIN; JIP1 PROTEIN; KINESIN 1; KINESIN 2; KINESIN INTERACTING PROTEIN; NEUROTROPHIN; RNA BINDING PROTEIN; SCAFFOLD PROTEIN; SIFA PROTEIN; SYNTAPHILIN PROTEIN; UNCLASSIFIED DRUG;

AUTOPHAGOSOME; AXONAL INJURY; BINDING AFFINITY; CALCIUM BINDING; CALCIUM TRANSPORT; CELL FUNCTION; CELL MATURATION; CELL MOTILITY; CELL SPECIFICITY; DENDRITE; ENDOSOME; ENERGY EXPENDITURE; ENZYME ACTIVITY; EXCITATORY POSTSYNAPTIC POTENTIAL; GLYCOLYSIS; HUMAN; INTRACELLULAR TRANSPORT; LYSOSOME; MICROTUBULE; MITOCHONDRION; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE FIBER TRANSPORT; NERVE POTENTIAL; NONHUMAN; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; RIBOSOME; SYNAPSE VESICLE; SYNAPTIC TRANSMISSION; TRANSPORT VESICLE; ANIMAL; CELL ORGANELLE; DEGENERATIVE DISEASE; METABOLISM; NERVE CELL; NERVE FIBER; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; AXONAL TRANSPORT; AXONS; HUMANS; NEURODEGENERATIVE DISEASES; NEURONS; ORGANELLES; SIGNAL TRANSDUCTION;

EID: 84908246114     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2014.10.019     Document Type: Review

References (273)

1. Abdollahi M.R., Morrison E., Sirey T., Molnar Z., Hayward B.E., Carr I.M., Springell K., Woods C.G., Ahmed M., Hattingh L., et al. Mutation of the variant alpha-tubulin TUBA8 results in polymicrogyria with optic nerve hypoplasia. Am. J. Hum. Genet. 2009, 85:737-744.
2. Akhmanova A., Hammer J.A. Linking molecular motors to membrane cargo. Curr. Opin. Cell Biol. 2010, 22:479-487.
3. Alami N.H., Smith R.B., Carrasco M.A., Williams L.A., Winborn C.S., Han S.S., Kiskinis E., Winborn B., Freibaum B.D., Kanagaraj A., et al. Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations. Neuron 2014, 81:536-543.
4. Alkuraya F.S., Cai X., Emery C., Mochida G.H., Al-Dosari M.S., Felie J.M., Hill R.S., Barry B.J., Partlow J.N., Gascon G.G., et al. Human mutations in NDE1 cause extreme microcephaly with lissencephaly [corrected]. Am. J. Hum. Genet. 2011, 88:536-547.
5. Allen R.D., Metuzals J., Tasaki I., Brady S.T., Gilbert S.P. Fast axonal transport in squid giant axon. Science 1982, 218:1127-1129.
6. Altar C.A., Cai N., Bliven T., Juhasz M., Conner J.M., Acheson A.L., Lindsay R.M., Wiegand S.J. Anterograde transport of brain-derived neurotrophic factor and its role in the brain. Nature 1997, 389:856-860.
7. Amrute-Nayak M., Bullock S.L. Single-molecule assays reveal that RNA localization signals regulate dynein-dynactin copy number on individual transcript cargoes. Nat. Cell Biol. 2012, 14:416-423.
8. Araki E., Tsuboi Y., Daechsel J., Milnerwood A., Vilarino-Guell C., Fujii N., Mishima T., Oka T., Hara H., Fukae J., et al. A novel DCTN1 mutation with late-onset parkinsonism and frontotemporal atrophy. Mov. Disord. 2014, 29:1201-1204.
9. Ashrafi G., Schlehe J.S., LaVoie M.J., Schwarz T.L. Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin. J.Cell Biol. 2014, 206:655-670.
10. Ayloo S., Lazarus J.E., Dodda A., Tokito M., Ostap E.M., Holzbaur E.L. Dynactin functions as both a dynamic tether and brake during dynein-driven motility. Nat. Commun. 2014, Published online September 4, 2014. 10.1038/ncomms5807.
11. Baas P.W., Deitch J.S., Black M.M., Banker G.A. Polarity orientation of microtubules in hippocampal neurons: uniformity in the axon and nonuniformity in the dendrite. Proc. Natl. Acad. Sci. USA 1988, 85:8335-8339.
12. Bakircioglu M., Carvalho O.P., Khurshid M., Cox J.J., Tuysuz B., Barak T., Yilmaz S., Caglayan O., Dincer A., Nicholas A.K., et al. The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis. Am. J. Hum. Genet. 2011, 88:523-535.
13. Bassell G.J., Zhang H., Byrd A.L., Femino A.M., Singer R.H., Taneja K.L., Lifshitz L.M., Herman I.M., Kosik K.S. Sorting of beta-actin mRNA and protein to neurites and growth cones in culture. J.Neurosci. 1998, 18:251-265.
14. Bhattacharyya A., Watson F.L., Pomeroy S.L., Zhang Y.Z., Stiles C.D., Segal R.A. High-resolution imaging demonstrates dynein-based vesicular transport of activated Trk receptors. J.Neurobiol. 2002, 51:302-312.
15. Bianco A., Dienstbier M., Salter H.K., Gatto G., Bullock S.L. Bicaudal-D regulates fragile X mental retardation protein levels, motility, and function during neuronal morphogenesis. Curr. Biol. 2010, 20:1487-1492.
16. Blasius T.L., Cai D., Jih G.T., Toret C.P., Verhey K.J. Two binding partners cooperate to activate the molecular motor Kinesin-1. J.Cell Biol. 2007, 176:11-17.
17. Brady S.T., Lasek R.J., Allen R.D. Fast axonal transport in extruded axoplasm from squid giant axon. Science 1982, 218:1129-1131.
18. Brown A. Slow axonal transport: stop and go traffic in the axon. Nat. Rev. Mol. Cell Biol. 2000, 1:153-156.
19. Brown A., Jung P. A critical reevaluation of the stationary axonal cytoskeleton hypothesis. Cytoskeleton (Hoboken) 2013, 70:1-11.
20. Brown C.L., Maier K.C., Stauber T., Ginkel L.M., Wordeman L., Vernos I., Schroer T.A. Kinesin-2 is a motor for late endosomes and lysosomes. Traffic 2005, 6:1114-1124.
21. Burton P.R., Paige J.L. Polarity of axoplasmic microtubules in the olfactory nerve of the frog. Proc. Natl. Acad. Sci. USA 1981, 78:3269-3273.
22. Cai Q., Gerwin C., Sheng Z.H. Syntabulin-mediated anterograde transport of mitochondria along neuronal processes. J.Cell Biol. 2005, 170:959-969.
23. Cai Q., Lu L., Tian J.H., Zhu Y.B., Qiao H., Sheng Z.H. Snapin-regulated late endosomal transport is critical for efficient autophagy-lysosomal function in neurons. Neuron 2010, 68:73-86.
24. Caroppo P., Le Ber I., Clot F., Rivaud-Pechoux S., Camuzat A., De Septenville A., Boutoleau-Bretonniere C., Mourlon V., Sauvee M., Lebouvier T., et al. DCTN1 mutation analysis in families with progressive supranuclear palsy-like phenotypes. JAMA Neurology 2014, 71:208-215.
25. Castle M.J., Perlson E., Holzbaur E.L., Wolfe J.H. Long-distance axonal transport of AAV9 is driven by dynein and kinesin-2 and is trafficked in a highly motile Rab7-positive compartment. Mol. Ther. 2014, 22:554-566.
26. Cavalli V., Kujala P., Klumperman J., Goldstein L.S. Sunday Driver links axonal transport to damage signaling. J.Cell Biol. 2005, 168:775-787.
27. Caviston J.P., Holzbaur E.L. Huntingtin as an essential integrator of intracellular vesicular trafficking. Trends Cell Biol. 2009, 19:147-155.
28. Chen Y., Sheng Z.H. Kinesin-1-syntaphilin coupling mediates activity-dependent regulation of axonal mitochondrial transport. J.Cell Biol. 2013, 202:351-364.
29. Chew S., Balasubramanian R., Chan W.M., Kang P.B., Andrews C., Webb B.D., MacKinnon S.E., Oystreck D.T., Rankin J., Crawford T.O., et al. A novel syndrome caused by the E410K amino acid substitution in the neuronal beta-tubulin isotype 3. Brain 2013, 136:522-535.
30. Cho Y., Cavalli V. HDAC5 is a novel injury-regulated tubulin deacetylase controlling axon regeneration. EMBO J. 2012, 31:3063-3078.
31. Cho K.I., Cai Y., Yi H., Yeh A., Aslanukov A., Ferreira P.A. Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function. Traffic 2007, 8:1722-1735.
32. Cho Y., Sloutsky R., Naegle K.M., Cavalli V. Injury-induced HDAC5 nuclear export is essential for axon regeneration. Cell 2013, 155:894-908.
33. Chowdary P.D., Che D.L., Cui B. Neurotrophin signaling via long-distance axonal transport. Annu. Rev. Phys. Chem. 2012, 63:571-594.
34. Colin E., Zala D., Liot G., Rangone H., Borrell-Pagès M., Li X.J., Saudou F., Humbert S. Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons. EMBO J. 2008, 27:2124-2134.
35. Cui B., Wu C., Chen L., Ramirez A., Bearer E.L., Li W.P., Mobley W.C., Chu S. One at a time, live tracking of NGF axonal transport using quantum dots. Proc. Natl. Acad. Sci. USA 2007, 104:13666-13671.
36. Culver-Hanlon T.L., Lex S.A., Stephens A.D., Quintyne N.J., King S.J. A microtubule-binding domain in dynactin increases dynein processivity by skating along microtubules. Nat. Cell Biol. 2006, 8:264-270.
37. Davidovic L., Jaglin X.H., Lepagnol-Bestel A.M., Tremblay S., Simonneau M., Bardoni B., Khandjian E.W. The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules. Hum. Mol. Genet. 2007, 16:3047-3058.
38. de Ligt J., Willemsen M.H., van Bon B.W., Kleefstra T., Yntema H.G., Kroes T., Vulto-van Silfhout A.T., Koolen D.A., de Vries P., Gilissen C., et al. Diagnostic exome sequencing in persons with severe intellectual disability. N.Engl. J. Med. 2012, 367:1921-1929.
39. Deinhardt K., Salinas S., Verastegui C., Watson R., Worth D., Hanrahan S., Bucci C., Schiavo G. Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway. Neuron 2006, 52:293-305.
40. Delcroix J.D., Valletta J.S., Wu C., Hunt S.J., Kowal A.S., Mobley W.C. NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron 2003, 39:69-84.
41. des Portes V., Francis F., Pinard J.M., Desguerre I., Moutard M.L., Snoeck I., Meiners L.C., Capron F., Cusmai R., Ricci S., et al. doublecortin is the major gene causing X-linked subcortical laminar heterotopia (SCLH). Hum. Mol. Genet. 1998, 7:1063-1070.
42. des Portes V., Pinard J.M., Billuart P., Vinet M.C., Koulakoff A., Carrie A., Gelot A., Dupuis E., Motte J., Berwald-Netter Y., et al. A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome. Cell 1998, 92:51-61.
43. Dieni S., Matsumoto T., Dekkers M., Rauskolb S., Ionescu M.S., Deogracias R., Gundelfinger E.D., Kojima M., Nestel S., Frotscher M., Barde Y.A. BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons. J.Cell Biol. 2012, 196:775-788.
44. Dix C.I., Soundararajan H.C., Dzhindzhev N.S., Begum F., Suter B., Ohkura H., Stephens E., Bullock S.L. Lissencephaly-1 promotes the recruitment of dynein and dynactin to transported mRNAs. J.Cell Biol. 2013, 202:479-494.
45. Dixit R., Levy J.R., Tokito M., Ligon L.A., Holzbaur E.L. Regulation of dynactin through the differential expression of p150Glued isoforms. J.Biol. Chem. 2008, 283:33611-33619.
46. Dixit R., Ross J.L., Goldman Y.E., Holzbaur E.L. Differential regulation of dynein and kinesin motor proteins by tau. Science 2008, 319:1086-1089.
47. Dobyns W.B., Reiner O., Carrozzo R., Ledbetter D.H. Lissencephaly. A human brain malformation associated with deletion of the LIS1 gene located at chromosome 17p13. JAMA 1993, 270:2838-2842.
48. Dor T., Cinnamon Y., Raymond L., Shaag A., Bouslam N., Bouhouche A., Gaussen M., Meyer V., Durr A., Brice A., et al. KIF1C mutations in two families with hereditary spastic paraparesis and cerebellar dysfunction. J.Med. Genet. 2014, 51:137-142.
49. Drerup C.M., Nechiporuk A.V. JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes. PLoS Genet. 2013, 9:e1003303.
50. Ebbing B., Mann K., Starosta A., Jaud J., Schöls L., Schüle R., Woehlke G. Effect of spastic paraplegia mutations in KIF5A kinesin on transport activity. Hum. Mol. Genet. 2008, 17:1245-1252.
51. Ehlers M.D., Kaplan D.R., Price D.L., Koliatsos V.E. NGF-stimulated retrograde transport of trkA in the mammalian nervous system. J.Cell Biol. 1995, 130:149-156.
52. Encalada S.E., Szpankowski L., Xia C.H., Goldstein L.S. Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles. Cell 2011, 144:551-565.
53. Erlich Y., Edvardson S., Hodges E., Zenvirt S., Thekkat P., Shaag A., Dor T., Hannon G.J., Elpeleg O. Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis. Genome Res. 2011, 21:658-664.
54. Falzone T.L., Stokin G.B., Lillo C., Rodrigues E.M., Westerman E.L., Williams D.S., Goldstein L.S. Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects. J.Neurosci. 2009, 29:5758-5767.
55. Farrer M.J., Hulihan M.M., Kachergus J.M., Dächsel J.C., Stoessl A.J., Grantier L.L., Calne S., Calne D.B., Lechevalier B., Chapon F., et al. DCTN1 mutations in Perry syndrome. Nat. Genet. 2009, 41:163-165.
56. Ferree A.W., Trudeau K., Zik E., Benador I.Y., Twig G., Gottlieb R.A., Shirihai O.S. MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age. Autophagy 2013, 9:1887-1896.
57. Fiorillo C., Moro F., Yi J., Weil S., Brisca G., Astrea G., Severino M., Romano A., Battini R., Rossi A., et al. Novel dynein DYNC1H1 neck and motor domain mutations link distal spinal muscular atrophy and abnormal cortical development. Hum. Mutat. 2014, 35:298-302.
58. Flynn K.C., Pak C.W., Shaw A.E., Bradke F., Bamburg J.R. Growth cone-like waves transport actin and promote axonogenesis and neurite branching. Dev. Neurobiol. 2009, 69:761-779.
59. Fransson A., Ruusala A., Aspenström P. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. J.Biol. Chem. 2003, 278:6495-6502.
60. Fransson S., Ruusala A., Aspenström P. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. Biochem. Biophys. Res. Commun. 2006, 344:500-510.
61. Fu M.M., Holzbaur E.L. JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors. J.Cell Biol. 2013, 202:495-508.
62. Fu M.-M., Holzbaur E.L. Integrated regulation of motor-driven organelle transport by scaffolding proteins. Trends Cell Biol. 2014, 24:564-574.
63. Fu M.-M., Nirschl J.J., Holzbaur E.L.F. LC3 binding to the scaffolding protein JIP1 regulates processive dynein-driven transport of autophagosomes. Dev. Cell 2014, 29:577-590.
64. Fujita T., Maturana A.D., Ikuta J., Hamada J., Walchli S., Suzuki T., Sawa H., Wooten M.W., Okajima T., Tatematsu K., et al. Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells. Biochem. Biophys. Res. Commun. 2007, 361:605-610.
65. Garner J.A., Mahler H.R. Biogenesis of presynaptic terminal proteins. J.Neurochem. 1987, 49:905-915.
66. Gauthier L.R., Charrin B.C., Borrell-Pagès M., Dompierre J.P., Rangone H., Cordelières F.P., De Mey J., MacDonald M.E., Lessmann V., Humbert S., Saudou F. Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 2004, 118:127-138.
67. Gleeson J.G., Allen K.M., Fox J.W., Lamperti E.D., Berkovic S., Scheffer I., Cooper E.C., Dobyns W.B., Minnerath S.R., Ross M.E., Walsh C.A. Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein. Cell 1998, 92:63-72.
68. Goodwin P.R., Sasaki J.M., Juo P. Cyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons. J.Neurosci. 2012, 32:8158-8172.
69. Griffin J.W., Price D.L., Drachman D.B., Engel W.K. Axonal transport to and from the motor nerve ending. Ann. N Y Acad. Sci. 1976, 274:31-45.
70. Grimes M.L., Beattie E., Mobley W.C. A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA. Proc. Natl. Acad. Sci. USA 1997, 94:9909-9914.
71. Gross S.P. Hither and yon: a review of bi-directional microtubule-based transport. Phys. Biol. 2004, 1:R1-R11.
72. Gross S.P., Vershinin M., Shubeita G.T. Cargo transport: two motors are sometimes better than one. Curr. Biol. 2007, 17:R478-R486.
73. Gumy L.F., Katrukha E.A., Kapitein L.C., Hoogenraad C.C. New insights into mRNA trafficking in axons. Dev. Neurobiol. 2014, 74:233-244.
74. Guo X., Macleod G.T., Wellington A., Hu F., Panchumarthi S., Schoenfield M., Marin L., Charlton M.P., Atwood H.L., Zinsmaier K.E. The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses. Neuron 2005, 47:379-393.
75. Hackney D.D. Evidence for alternating head catalysis by kinesin during microtubule-stimulated ATP hydrolysis. Proc. Natl. Acad. Sci. USA 1994, 91:6865-6869.
76. Hall D.H., Hedgecock E.M. Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans. Cell 1991, 65:837-847.
77. Hamdan F.F., Gauthier J., Araki Y., Lin D.T., Yoshizawa Y., Higashi K., Park A.R., Spiegelman D., Dobrzeniecka S., Piton A., et al. Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability. Am. J. Hum. Genet. 2011, 88:306-316. S2D Group.
78. Hammond J.W., Huang C.F., Kaech S., Jacobson C., Banker G., Verhey K.J. Posttranslational modifications of tubulin and the polarized transport of kinesin-1 in neurons. Mol. Biol. Cell 2010, 21:572-583.
79. Hanz S., Perlson E., Willis D., Zheng J.Q., Massarwa R., Huerta J.J., Koltzenburg M., Kohler M., van-Minnen J., Twiss J.L., Fainzilber M. Axoplasmic importins enable retrograde injury signaling in lesioned nerve. Neuron 2003, 40:1095-1104.
80. Hara T., Nakamura K., Matsui M., Yamamoto A., Nakahara Y., Suzuki-Migishima R., Yokoyama M., Mishima K., Saito I., Okano H., Mizushima N. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006, 441:885-889.
81. Harada A., Takei Y., Kanai Y., Tanaka Y., Nonaka S., Hirokawa N. Golgi vesiculation and lysosome dispersion in cells lacking cytoplasmic dynein. J.Cell Biol. 1998, 141:51-59.
82. Harms M.B., Ori-McKenney K.M., Scoto M., Tuck E.P., Bell S., Ma D., Masi S., Allred P., Al-Lozi M., Reilly M.M., et al. Mutations in the tail domain of DYNC1H1 cause dominant spinal muscular atrophy. Neurology 2012, 78:1714-1720.
83. Harrington A.W., Ginty D.D. Long-distance retrograde neurotrophic factor signalling in neurons. Nat. Rev. Neurosci. 2013, 14:177-187.
84. Harris J.J., Attwell D. The energetics of CNS white matter. J.Neurosci. 2012, 32:356-371.
85. Hazan J., Fonknechten N., Mavel D., Paternotte C., Samson D., Artiguenave F., Davoine C.S., Cruaud C., Dürr A., Wincker P., et al. Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia. Nat. Genet. 1999, 23:296-303.
86. Heerssen H.M., Pazyra M.F., Segal R.A. Dynein motors transport activated Trks to promote survival of target-dependent neurons. Nat. Neurosci. 2004, 7:596-604.
87. Hendricks A.G., Perlson E., Ross J.L., Schroeder H.W., Tokito M., Holzbaur E.L. Motor coordination via a tug-of-war mechanism drives bidirectional vesicle transport. Curr. Biol. 2010, 20:697-702.
88. Hendricks A.G., Holzbaur E.L., Goldman Y.E. Force measurements on cargoes in living cells reveal collective dynamics of microtubule motors. Proc. Natl. Acad. Sci. USA 2012, 109:18447-18452.
89. Hirokawa N., Sato-Yoshitake R., Yoshida T., Kawashima T. Brain dynein (MAP1C) localizes on both anterogradely and retrogradely transported membranous organelles invivo. J.Cell Biol. 1990, 111:1027-1037.
90. Hirokawa N., Sato-Yoshitake R., Kobayashi N., Pfister K.K., Bloom G.S., Brady S.T. Kinesin associates with anterogradely transported membranous organelles invivo. J.Cell Biol. 1991, 114:295-302.
91. Hirokawa N., Niwa S., Tanaka Y. Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease. Neuron 2010, 68:610-638.
92. Hoeprich G.J., Thompson A.R., McVicker D.P., Hancock W.O., Berger C.L. Kinesin's neck-linker determines its ability to navigate obstacles on the microtubule surface. Biophys. J. 2014, 106:1691-1700.
93. Hollenbeck P.J. Products of endocytosis and autophagy are retrieved from axons by regulated retrograde organelle transport. J.Cell Biol. 1993, 121:305-315.
94. Hollenbeck P.J., Saxton W.M. The axonal transport of mitochondria. J.Cell Sci. 2005, 118:5411-5419.
95. Holleran E.A., Tokito M.K., Karki S., Holzbaur E.L. Centractin (ARP1) associates with spectrin revealing a potential mechanism to link dynactin to intracellular organelles. J.Cell Biol. 1996, 135:1815-1829.
96. Holleran E.A., Ligon L.A., Tokito M., Stankewich M.C., Morrow J.S., Holzbaur E.L. Beta III spectrin binds to the Arp1 subunit of dynactin. J.Biol. Chem. 2001, 276:36598-36605.
97. Holt C.E., Schuman E.M. The central dogma decentralized: new perspectives on RNA function and local translation in neurons. Neuron 2013, 80:648-657.
98. Holzbaur E.L., Hammarback J.A., Paschal B.M., Kravit N.G., Pfister K.K., Vallee R.B. Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued. Nature 1991, 351:579-583.
99. Horiuchi D., Barkus R.V., Pilling A.D., Gassman A., Saxton W.M. APLIP1, a kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport of both vesicles and mitochondria in Drosophila. Curr. Biol. 2005, 15:2137-2141.
100. Horiuchi D., Collins C.A., Bhat P., Barkus R.V., Diantonio A., Saxton W.M. Control of a kinesin-cargo linkage mechanism by JNK pathway kinases. Curr. Biol. 2007, 17:1313-1317.
101. Huang J., Roberts A.J., Leschziner A.E., Reck-Peterson S.L. Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor. Cell 2012, 150:975-986.
102. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993, 72:971-983. HDCRG (Huntington's Disease Collaborative Research Group).
103. Hutton M., Lendon C.L., Rizzu P., Baker M., Froelich S., Houlden H., Pickering-Brown S., Chakraverty S., Isaacs A., Grover A., et al. Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 1998, 393:702-705.
104. Ikuta J., Maturana A., Fujita T., Okajima T., Tatematsu K., Tanizawa K., Kuroda S. Fasciculation and elongation protein zeta-1 (FEZ1) participates in the polarization of hippocampal neuron by controlling the mitochondrial motility. Biochem. Biophys. Res. Commun. 2007, 353:127-132.
105. Jacobson C., Schnapp B., Banker G.A. A change in the selective translocation of the Kinesin-1 motor domain marks the initial specification of the axon. Neuron 2006, 49:797-804.
106. Jaglin X.H., Poirier K., Saillour Y., Buhler E., Tian G., Bahi-Buisson N., Fallet-Bianco C., Phan-Dinh-Tuy F., Kong X.P., Bomont P., et al. Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. Nat. Genet. 2009, 41:746-752.
107. Janke C., Bulinski J.C. Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions. Nat. Rev. Mol. Cell Biol. 2011, 12:773-786.
108. Johansson M., Rocha N., Zwart W., Jordens I., Janssen L., Kuijl C., Olkkonen V.M., Neefjes J. Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued, ORP1L, and the receptor betalll spectrin. J.Cell Biol. 2007, 176:459-471.
109. Jones S.L., Korobova F., Svitkina T. Axon initial segment cytoskeleton comprises a multiprotein submembranous coat containing sparse actin filaments. J.Cell Biol. 2014, 205:67-81.
110. Jordens I., Fernandez-Borja M., Marsman M., Dusseljee S., Janssen L., Calafat J., Janssen H., Wubbolts R., Neefjes J. The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors. Curr. Biol. 2001, 11:1680-1685.
111. Kaan H.Y., Hackney D.D., Kozielski F. The structure of the kinesin-1 motor-tail complex reveals the mechanism of autoinhibition. Science 2011, 333:883-885.
112. Kaether C., Skehel P., Dotti C.G. Axonal membrane proteins are transported in distinct carriers: a two-color video microscopy study in cultured hippocampal neurons. Mol. Biol. Cell 2000, 11:1213-1224.
113. Kamal A., Stokin G.B., Yang Z., Xia C.H., Goldstein L.S. Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Neuron 2000, 28:449-459.
114. Kanai Y., Dohmae N., Hirokawa N. Kinesin transports RNA: isolation and characterization of an RNA-transporting granule. Neuron 2004, 43:513-525.
115. Kang J.S., Tian J.H., Pan P.Y., Zald P., Li C., Deng C., Sheng Z.H. Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation. Cell 2008, 132:137-148.
116. Kapitein L.C., Schlager M.A., Kuijpers M., Wulf P.S., van Spronsen M., MacKintosh F.C., Hoogenraad C.C. Mixed microtubules steer dynein-driven cargo transport into dendrites. Curr. Biol. 2010, 20:290-299.
117. Kapur M., Maloney M.T., Wang W., Chen X., Millan I., Mooney T., Yang J., Yang Y. A SxIP motif interaction at the microtubule plus end is important for processive retrograde axonal transport. Cell. Mol. Life Sci. 2014, 71:4043-4054.
118. Karki S., Holzbaur E.L. Affinity chromatography demonstrates a direct binding between cytoplasmic dynein and the dynactin complex. J.Biol. Chem. 1995, 270:28806-28811.
119. Keays D.A., Tian G., Poirier K., Huang G.J., Siebold C., Cleak J., Oliver P.L., Fray M., Harvey R.J., Molnár Z., et al. Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans. Cell 2007, 128:45-57.
120. King S.J., Schroer T.A. Dynactin increases the processivity of the cytoplasmic dynein motor. Nat. Cell Biol. 2000, 2:20-24.
121. Klebe S., Lossos A., Azzedine H., Mundwiller E., Sheffer R., Gaussen M., Marelli C., Nawara M., Carpentier W., Meyer V., et al. KIF1A missense mutations in SPG30, an autosomal recessive spastic paraplegia: distinct phenotypes according to the nature of the mutations. Eur. J. Hum. Genet. 2012, 20:645-649.
122. Kleele T., Marinković P., Williams P.R., Stern S., Weigand E.E., Engerer P., Naumann R., Hartmann J., Karl R.M., Bradke F., et al. An assay to image neuronal microtubule dynamics in mice. Nat. Commun. 2014, 5:4827.
123. Klopfenstein D.R., Vale R.D. The lipid binding pleckstrin homology domain in UNC-104 kinesin is necessary for synaptic vesicle transport in Caenorhabditis elegans. Mol. Biol. Cell 2004, 15:3729-3739.
124. Knowles R.B., Sabry J.H., Martone M.E., Deerinck T.J., Ellisman M.H., Bassell G.J., Kosik K.S. Translocation of RNA granules in living neurons. J.Neurosci. 1996, 16:7812-7820.
125. Komatsu M., Waguri S., Chiba T., Murata S., Iwata J., Tanida I., Ueno T., Koike M., Uchiyama Y., Kominami E., Tanaka K. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006, 441:880-884.
126. Komatsu M., Wang Q.J., Holstein G.R., Friedrich V.L., Iwata J., Kominami E., Chait B.T., Tanaka K., Yue Z. Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc. Natl. Acad. Sci. USA 2007, 104:14489-14494.
127. Kondo M., Takei Y., Hirokawa N. Motor protein KIF1A is essential for hippocampal synaptogenesis and learning enhancement in an enriched environment. Neuron 2012, 73:743-757.
128. Konishi Y., Setou M. Tubulin tyrosination navigates the kinesin-1 motor domain to axons. Nat. Neurosci. 2009, 12:559-567.
129. Kreutzberg G.W. Neuronal dynamics and axonal flow. IV. Blockage of intra-axonal enzyme transport by colchicine. Proc. Natl. Acad. Sci. USA 1969, 62:722-728.
130. Krichevsky A.M., Kosik K.S. Neuronal RNA granules: a link between RNA localization and stimulation-dependent translation. Neuron 2001, 32:683-696.
131. Kuijpers M., Hoogenraad C.C. Centrosomes, microtubules and neuronal development. Mol. Cell. Neurosci. 2011, 48:349-358.
132. Kuta A., Deng W., Morsi El-Kadi A., Banks G.T., Hafezparast M., Pfister K.K., Fisher E.M. Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts. PLoS ONE 2010, 5:e11682.
133. Kwan A.C., Dombeck D.A., Webb W.W. Polarized microtubule arrays in apical dendrites and axons. Proc. Natl. Acad. Sci. USA 2008, 105:11370-11375.
134. LaMonte B.H., Wallace K.E., Holloway B.A., Shelly S.S., Ascaño J., Tokito M., Van Winkle T., Howland D.S., Holzbaur E.L. Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration. Neuron 2002, 34:715-727.
135. Larti F., Kahrizi K., Musante L., Hu H., Papari E., Fattahi Z., Bazazzadegan N., Liu Z., Banan M., Garshasbi M., et al. A defect in the CLIP1 gene (CLIP-170) can cause autosomal recessive intellectual disability. Eur. J. Hum. Genet. 2014, 10.1038/ejhg.2014.13.
136. Lawrence C.J., Dawe R.K., Christie K.R., Cleveland D.W., Dawson S.C., Endow S.A., Goldstein L.S., Goodson H.V., Hirokawa N., Howard J., et al. A standardized kinesin nomenclature. J.Cell Biol. 2004, 167:19-22.
137. Lee S., Sato Y., Nixon R.A. Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy. J.Neurosci. 2011, 31:7817-7830.
138. Lenz J.H., Schuchardt I., Straube A., Steinberg G. A dynein loading zone for retrograde endosome motility at microtubule plus-ends. EMBO J. 2006, 25:2275-2286.
139. Leterrier C., Vacher H., Fache M.P., d'Ortoli S.A., Castets F., Autillo-Touati A., Dargent B. End-binding proteins EB3 and EB1 link microtubules to ankyrin G in the axon initial segment. Proc. Natl. Acad. Sci. USA 2011, 108:8826-8831.
140. Li Z., Okamoto K., Hayashi Y., Sheng M. The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Cell 2004, 119:873-887.
141. Li Y., Jung P., Brown A. Axonal transport of neurofilaments: a single population of intermittently moving polymers. J.Neurosci. 2012, 32:746-758.
142. Ling S.C., Fahrner P.S., Greenough W.T., Gelfand V.I. Transport of Drosophila fragile X mental retardation protein-containing ribonucleoprotein granules by kinesin-1 and cytoplasmic dynein. Proc. Natl. Acad. Sci. USA 2004, 101:17428-17433.
143. Lloyd T.E., Machamer J., O'Hara K., Kim J.H., Collins S.E., Wong M.Y., Sahin B., Imlach W., Yang Y., Levitan E.S., et al. The p150(Glued) CAP-Gly domain regulates initiation of retrograde transport at synaptic termini. Neuron 2012, 74:344-360.
144. Lo K.Y., Kuzmin A., Unger S.M., Petersen J.D., Silverman M.A. KIF1A is the primary anterograde motor protein required for the axonal transport of dense-core vesicles in cultured hippocampal neurons. Neurosci. Lett. 2011, 491:168-173.
145. MacAskill A.F., Kittler J.T. Control of mitochondrial transport and localization in neurons. Trends Cell Biol. 2010, 20:102-112.
146. MacAskill A.F., Brickley K., Stephenson F.A., Kittler J.T. GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons. Mol. Cell. Neurosci. 2009, 40:301-312.
147. Macaskill A.F., Rinholm J.E., Twelvetrees A.E., Arancibia-Carcamo I.L., Muir J., Fransson A., Aspenstrom P., Attwell D., Kittler J.T. Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses. Neuron 2009, 61:541-555.
148. Maday S., Holzbaur E.L. Autophagosome biogenesis in primary neurons follows an ordered and spatially regulated pathway. Dev. Cell 2014, 30:71-85.
149. Maday S., Wallace K.E., Holzbaur E.L. Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons. J.Cell Biol. 2012, 196:407-417.
150. Mallik R., Carter B.C., Lex S.A., King S.J., Gross S.P. Cytoplasmic dynein functions as a gear in response to load. Nature 2004, 427:649-652.
151. Mallik R., Petrov D., Lex S.A., King S.J., Gross S.P. Building complexity: an invitro study of cytoplasmic dynein with invivo implications. Curr. Biol. 2005, 15:2075-2085.
152. Mallik R., Rai A.K., Barak P., Rai A., Kunwar A. Teamwork in microtubule motors. Trends Cell Biol. 2013, 23:575-582.
153. Matanis T., Akhmanova A., Wulf P., Del Nery E., Weide T., Stepanova T., Galjart N., Grosveld F., Goud B., De Zeeuw C.I., et al. Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Nat. Cell Biol. 2002, 4:986-992.
154. Matsuda S., Yasukawa T., Homma Y., Ito Y., Niikura T., Hiraki T., Hirai S., Ohno S., Kita Y., Kawasumi M., et al. c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J.Neurosci. 2001, 21:6597-6607.
155. McEwen B.S., Grafstein B. Fast and slow components in axonal transport of protein. J.Cell Biol. 1968, 38:494-508.
156. McKenney R.J., Huynh W., Tanenbaum M.E., Bhabha G., Vale R.D. Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science 2014, 345:337-341.
157. Merianda T.T., Lin A.C., Lam J.S., Vuppalanchi D., Willis D.E., Karin N., Holt C.E., Twiss J.L. A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins. Mol. Cell. Neurosci. 2009, 40:128-142.
158. Merianda T.T., Gomes C., Yoo S., Vuppalanchi D., Twiss J.L. Axonal localization of neuritin/CPG15 mRNA in neuronal populations through distinct 5' and 3' UTR elements. J.Neurosci. 2013, 33:13735-13742.
159. Mersiyanova I.V., Perepelov A.V., Polyakov A.V., Sitnikov V.F., Dadali E.L., Oparin R.B., Petrin A.N., Evgrafov O.V. A new variant of Charcot-Marie-Tooth disease type 2 is probably the result of a mutation in the neurofilament-light gene. Am. J. Hum. Genet. 2000, 67:37-46.
160. Miki H., Setou M., Kaneshiro K., Hirokawa N. All kinesin superfamily protein, KIF, genes in mouse and human. Proc. Natl. Acad. Sci. USA 2001, 98:7004-7011.
161. Millecamps S., Julien J.P. Axonal transport deficits and neurodegenerative diseases. Nat. Rev. Neurosci. 2013, 14:161-176.
162. Miller K.E., DeProto J., Kaufmann N., Patel B.N., Duckworth A., Van Vactor D. Direct observation demonstrates that Liprin-alpha is required for trafficking of synaptic vesicles. Curr. Biol. 2005, 15:684-689.
163. Misgeld T., Kerschensteiner M., Bareyre F.M., Burgess R.W., Lichtman J.W. Imaging axonal transport of mitochondria invivo. Nat. Methods 2007, 4:559-561.
164. Mitchell D.J., Blasier K.R., Jeffery E.D., Ross M.W., Pullikuth A.K., Suo D., Park J., Smiley W.R., Lo K.W., Shabanowitz J., et al. Trk activation of the ERK1/2 kinase pathway stimulates intermediate chain phosphorylation and recruits cytoplasmic dynein to signaling endosomes for retrograde axonal transport. J.Neurosci. 2012, 32:15495-15510.
165. Morfini G.A., Bosco D.A., Brown H., Gatto R., Kaminska A., Song Y., Molla L., Baker L., Marangoni M.N., Berth S., et al. Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase. PLoS ONE 2013, 8:e65235.
166. Moughamian A.J., Holzbaur E.L. Dynactin is required for transport initiation from the distal axon. Neuron 2012, 74:331-343.
167. Moughamian A.J., Osborn G.E., Lazarus J.E., Maday S., Holzbaur E.L. Ordered recruitment of dynactin to the microtubule plus-end is required for efficient initiation of retrograde axonal transport. J.Neurosci. 2013, 33:13190-13203.
168. Müller M.J., Klumpp S., Lipowsky R. Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors. Proc. Natl. Acad. Sci. USA 2008, 105:4609-4614.
169. Murrell J.R., Spillantini M.G., Zolo P., Guazzelli M., Smith M.J., Hasegawa M., Redi F., Crowther R.A., Pietrini P., Ghetti B., Goedert M. Tau gene mutation G389R causes a tauopathy with abundant pick body-like inclusions and axonal deposits. J.Neuropathol. Exp. Neurol. 1999, 58:1207-1226.
170. Nakata T., Hirokawa N. Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head. J.Cell Biol. 2003, 162:1045-1055.
171. Nakata T., Niwa S., Okada Y., Perez F., Hirokawa N. Preferential binding of a kinesin-1 motor to GTP-tubulin-rich microtubules underlies polarized vesicle transport. J.Cell Biol. 2011, 194:245-255.
172. Nangaku M., Sato-Yoshitake R., Okada Y., Noda Y., Takemura R., Yamazaki H., Hirokawa N. KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria. Cell 1994, 79:1209-1220.
173. Neveling K., Martinez-Carrera L.A., Hölker I., Heister A., Verrips A., Hosseini-Barkooie S.M., Gilissen C., Vermeer S., Pennings M., Meijer R., et al. Mutations in BICD2, which encodes a golgin and important motor adaptor, cause congenital autosomal-dominant spinal muscular atrophy. Am. J. Hum. Genet. 2013, 92:946-954.
174. Niwa S., Tanaka Y., Hirokawa N. KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD. Nat. Cell Biol. 2008, 10:1269-1279.
175. Novarino G., Fenstermaker A.G., Zaki M.S., Hofree M., Silhavy J.L., Heiberg A.D., Abdellateef M., Rosti B., Scott E., Mansour L., et al. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. Science 2014, 343:506-511.
176. Oates E.C., Rossor A.M., Hafezparast M., Gonzalez M., Speziani F., MacArthur D.G., Lek M., Cottenie E., Scoto M., Foley A.R., et al. Mutations in BICD2 cause dominant congenital spinal muscular atrophy and hereditary spastic paraplegia. Am. J. Hum. Genet. 2013, 92:965-973. UK10K.
177. Okada Y., Yamazaki H., Sekine-Aizawa Y., Hirokawa N. The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors. Cell 1995, 81:769-780.
178. Paciorkowski A.R., Keppler-Noreuil K., Robinson L., Sullivan C., Sajan S., Christian S.L., Bukshpun P., Gabriel S.B., Gleeson J.G., Sherr E.H., Dobyns W.B. Deletion 16p13.11 uncovers NDE1 mutations on the non-deleted homolog and extends the spectrum of severe microcephaly to include fetal brain disruption. Am. J. Med. Genet. A. 2013, 161A:1523-1530.
179. Pandey J.P., Smith D.S. A Cdk5-dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons. J.Neurosci. 2011, 31:17207-17219.
180. Paschal B.M., Shpetner H.S., Vallee R.B. MAP 1C is a microtubule-activated ATPase which translocates microtubules invitro and has dynein-like properties. J.Cell Biol. 1987, 105:1273-1282.
181. Patil H., Cho K.I., Lee J., Yang Y., Orry A., Ferreira P.A. Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2. Open Biol. 2013, 3:120183. 10.1098/rsob.120183.
182. Peeters K., Litvinenko I., Asselbergh B., Almeida-Souza L., Chamova T., Geuens T., Ydens E., Zimoń M., Irobi J., De Vriendt E., et al. Molecular defects in the motor adaptor BICD2 cause proximal spinal muscular atrophy with autosomal-dominant inheritance. Am. J. Hum. Genet. 2013, 92:955-964.
183. Perlson E., Hanz S., Ben-Yaakov K., Segal-Ruder Y., Seger R., Fainzilber M. Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve. Neuron 2005, 45:715-726.
184. Perry R.B., Doron-Mandel E., Iavnilovitch E., Rishal I., Dagan S.Y., Tsoory M., Coppola G., McDonald M.K., Gomes C., Geschwind D.H., et al. Subcellular knockout of importin β1 perturbs axonal retrograde signaling. Neuron 2012, 75:294-305.
185. Petersen J.D., Kaech S., Banker G. Selective microtubule-based transport of dendritic membrane proteins arises in concert with axon specification. J.Neurosci. 2014, 34:4135-4147.
186. Pilling A.D., Horiuchi D., Lively C.M., Saxton W.M. Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons. Mol. Biol. Cell 2006, 17:2057-2068.
187. Poirier K., Keays D.A., Francis F., Saillour Y., Bahi N., Manouvrier S., Fallet-Bianco C., Pasquier L., Toutain A., Tuy F.P., et al. Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A). Hum. Mutat. 2007, 28:1055-1064.
188. Poirier K., Saillour Y., Bahi-Buisson N., Jaglin X.H., Fallet-Bianco C., Nabbout R., Castelnau-Ptakhine L., Roubertie A., Attie-Bitach T., Desguerre I., et al. Mutations in the neuronal β-tubulin subunit TUBB3 result in malformation of cortical development and neuronal migration defects. Hum. Mol. Genet 2010, 19:4462-4473.
189. Poirier K., Lebrun N., Broix L., Tian G., Saillour Y., Boscheron C., Parrini E., Valence S., Pierre B.S., Oger M., et al. Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly. Nat. Genet. 2013, 45:639-647.
190. Puls I., Jonnakuty C., LaMonte B.H., Holzbaur E.L., Tokito M., Mann E., Floeter M.K., Bidus K., Drayna D., Oh S.J., et al. Mutant dynactin in motor neuron disease. Nat. Genet. 2003, 33:455-456.
191. Rai A.K., Rai A., Ramaiya A.J., Jha R., Mallik R. Molecular adaptations allow dynein to generate large collective forces inside cells. Cell 2013, 152:172-182.
192. Ray K., Perez S.E., Yang Z., Xu J., Ritchings B.W., Steller H., Goldstein L.S. Kinesin-II is required for axonal transport of choline acetyltransferase in Drosophila. J.Cell Biol. 1999, 147:507-518.
193. Reiner O., Carrozzo R., Shen Y., Wehnert M., Faustinella F., Dobyns W.B., Caskey C.T., Ledbetter D.H. Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats. Nature 1993, 364:717-721.
194. Rishal I., Fainzilber M. Axon-soma communication in neuronal injury. Nat. Rev. Neurosci. 2014, 15:32-42.
195. Rivière J.B., Ramalingam S., Lavastre V., Shekarabi M., Holbert S., Lafontaine J., Srour M., Merner N., Rochefort D., Hince P., et al. KIF1A, an axonal transporter of synaptic vesicles, is mutated in hereditary sensory and autonomic neuropathy type 2. Am. J. Hum. Genet. 2011, 89:219-230.
196. Roberts A.J., Kon T., Knight P.J., Sutoh K., Burgess S.A. Functions and mechanics of dynein motor proteins. Nat. Rev. Mol. Cell Biol. 2013, 14:713-726.
197. Rosa-Ferreira C., Munro S. Arl8 and SKIP act together to link lysosomes to kinesin-1. Dev. Cell 2011, 21:1171-1178.
198. Ross J.L., Wallace K., Shuman H., Goldman Y.E., Holzbaur E.L. Processive bidirectional motion of dynein-dynactin complexes invitro. Nat. Cell Biol. 2006, 8:562-570.
199. Roy S. Seeing the unseen: the hidden world of slow axonal transport. Neuroscientist 2014, 20:71-81.
200. Russo G.J., Louie K., Wellington A., Macleod G.T., Hu F., Panchumarthi S., Zinsmaier K.E. Drosophila Miro is required for both anterograde and retrograde axonal mitochondrial transport. J.Neurosci. 2009, 29:5443-5455.
201. Saab A.S., Tzvetanova I.D., Nave K.A. The role of myelin and oligodendrocytes in axonal energy metabolism. Curr. Opin. Neurobiol. 2013, 23:1065-1072.
202. Sajic M., Mastrolia V., Lee C.Y., Trigo D., Sadeghian M., Mosley A.J., Gregson N.A., Duchen M.R., Smith K.J. Impulse conduction increases mitochondrial transport in adult mammalian peripheral nerves invivo. PLoS Biol. 2013, 11:e1001754.
203. Salata M.W., Dillman J.F., Lye R.J., Pfister K.K. Growth factor regulation of cytoplasmic dynein intermediate chain subunit expression preceding neurite extension. J.Neurosci. Res. 2001, 65:408-416.
204. Sandow S.L., Heydon K., Weible M.W., Reynolds A.J., Bartlett S.E., Hendry I.A. Signalling organelle for retrograde axonal transport of internalized neurotrophins from the nerve terminal. Immunol. Cell Biol. 2000, 78:430-435.
205. Scheinfeld M.H., Roncarati R., Vito P., Lopez P.A., Abdallah M., D'Adamio L. Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). J.Biol. Chem. 2002, 277:3767-3775.
206. Schlager M.A., Hoang H.T., Urnavicius L., Bullock S.L., Carter A.P. Invitro reconstitution of a highly processive recombinant human dynein complex. EMBO J. 2014, 33:1855-1868.
207. Scholey J.M. Kinesin-2: a family of heterotrimeric and homodimeric motors with diverse intracellular transport functions. Annu. Rev. Cell Dev. Biol. 2013, 29:443-469.
208. Schroeder H.W., Mitchell C., Shuman H., Holzbaur E.L., Goldman Y.E. Motor number controls cargo switching at actin-microtubule intersections invitro. Curr. Biol. 2010, 20:687-696.
209. Schroeder H.W., Hendricks A.G., Ikeda K., Shuman H., Rodionov V., Ikebe M., Goldman Y.E., Holzbaur E.L. Force-dependent detachment of kinesin-2 biases track switching at cytoskeletal filament intersections. Biophys. J. 2012, 103:48-58.
210. Schroer T.A. Dynactin. Annu. Rev. Cell Dev. Biol. 2004, 20:759-779.
211. Scott D.A., Das U., Tang Y., Roy S. Mechanistic logic underlying the axonal transport of cytosolic proteins. Neuron 2011, 70:441-454.
212. Serano T.L., Cohen R.S. A small predicted stem-loop structure mediates oocyte localization of Drosophila K10 mRNA. Development 1995, 121:3809-3818.
213. Setou M., Seog D.H., Tanaka Y., Kanai Y., Takei Y., Kawagishi M., Hirokawa N. Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites. Nature 2002, 417:83-87.
214. Shah J.V., Flanagan L.A., Janmey P.A., Leterrier J.F. Bidirectional translocation of neurofilaments along microtubules mediated in part by dynein/dynactin. Mol. Biol. Cell 2000, 11:3495-3508.
215. Shao C.Y., Zhu J., Xie Y.J., Wang Z., Wang Y.N., Wang Y., Su L.D., Zhou L., Zhou T.H., Shen Y. Distinct functions of nuclear distribution proteins LIS1, Ndel1 and NudCL in regulating axonal mitochondrial transport. Traffic 2013, 14:785-797.
216. Shin H., Wyszynski M., Huh K.H., Valtschanoff J.G., Lee J.R., Ko J., Streuli M., Weinberg R.J., Sheng M., Kim E. Association of the kinesin motor KIF1A with the multimodular protein liprin-alpha. J.Biol. Chem. 2003, 278:11393-11401.
217. Shin J.E., Miller B.R., Babetto E., Cho Y., Sasaki Y., Qayum S., Russler E.V., Cavalli V., Milbrandt J., DiAntonio A. SCG10 is a JNK target in the axonal degeneration pathway. Proc. Natl. Acad. Sci. USA 2012, 109:E3696-E3705.
218. Silverman M.A., Kaech S., Ramser E.M., Lu X., Lasarev M.R., Nagalla S., Banker G. Expression of kinesin superfamily genes in cultured hippocampal neurons. Cytoskeleton (Hoboken) 2010, 67:784-795.
219. Sirajuddin M., Rice L.M., Vale R.D. Regulation of microtubule motors by tubulin isotypes and post-translational modifications. Nat. Cell Biol. 2014, 16:335-344.
220. Song A.H., Wang D., Chen G., Li Y., Luo J., Duan S., Poo M.M. A selective filter for cytoplasmic transport at the axon initial segment. Cell 2009, 136:1148-1160.
221. Song Y., Nagy M., Ni W., Tyagi N.K., Fenton W.A., López-Giráldez F., Overton J.D., Horwich A.L., Brady S.T. Molecular chaperone Hsp110 rescues a vesicle transport defect produced by an ALS-associated mutant SOD1 protein in squid axoplasm. Proc. Natl. Acad. Sci. USA 2013, 110:5428-5433.
222. Soppina V., Rai A.K., Ramaiya A.J., Barak P., Mallik R. Tug-of-war between dissimilar teams of microtubule motors regulates transport and fission of endosomes. Proc. Natl. Acad. Sci. USA 2009, 106:19381-19386.
223. Soppina V., Norris S.R., Dizaji A.S., Kortus M., Veatch S., Peckham M., Verhey K.J. Dimerization of mammalian kinesin-3 motors results in superprocessive motion. Proc. Natl. Acad. Sci. USA 2014, 111:5562-5567.
224. Stepanova T., Slemmer J., Hoogenraad C.C., Lansbergen G., Dortland B., De Zeeuw C.I., Grosveld F., van Cappellen G., Akhmanova A., Galjart N. Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein). J.Neurosci. 2003, 23:2655-2664.
225. Stepanova T., Smal I., van Haren J., Akinci U., Liu Z., Miedema M., Limpens R., van Ham M., van der Reijden M., Poot R., et al. History-dependent catastrophes regulate axonal microtubule behavior. Curr. Biol. 2010, 20:1023-1028.
226. Sun F., Zhu C., Dixit R., Cavalli V. Sunday Driver/JIP3 binds kinesin heavy chain directly and enhances its motility. EMBO J. 2011, 30:3416-3429.
227. Sun T., Qiao H., Pan P.Y., Chen Y., Sheng Z.H. Motile axonal mitochondria contribute to the variability of presynaptic strength. Cell Rep. 2013, 4:413-419.
228. Svoboda K., Block S.M. Force and velocity measured for single kinesin molecules. Cell 1994, 77:773-784.
229. Takeda S., Yamazaki H., Seog D.H., Kanai Y., Terada S., Hirokawa N. Kinesin superfamily protein 3 (KIF3) motor transports fodrin-associating vesicles important for neurite building. J.Cell Biol. 2000, 148:1255-1265.
230. Tan S.C., Scherer J., Vallee R.B. Recruitment of dynein to late endosomes and lysosomes through light intermediate chains. Mol. Biol. Cell 2011, 22:467-477.
231. Tanaka K., Sugiura Y., Ichishita R., Mihara K., Oka T. KLP6: a newly identified kinesin that regulates the morphology and transport of mitochondria in neuronal cells. J.Cell Sci. 2011, 124:2457-2465.
232. Tang Y., Scott D., Das U., Gitler D., Ganguly A., Roy S. Fast vesicle transport is required for the slow axonal transport of synapsin. J.Neurosci. 2013, 33:15362-15375.
233. Teng J., Rai T., Tanaka Y., Takei Y., Nakata T., Hirasawa M., Kulkarni A.B., Hirokawa N. The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. Nat. Cell Biol. 2005, 7:474-482.
234. Terada S., Kinjo M., Hirokawa N. Oligomeric tubulin in large transporting complex is transported via kinesin in squid giant axons. Cell 2000, 103:141-155.
235. Terada S., Kinjo M., Aihara M., Takei Y., Hirokawa N. Kinesin-1/Hsc70-dependent mechanism of slow axonal transport and its relation to fast axonal transport. EMBO J. 2010, 29:843-854.
236. Terenzio M., Golding M., Russell M.R.G., Wicher K.B., Rosewell I., Spencer-Dene B., Ish-Horowicz D., Schiavo G. Bicaudal-D1 regulates the intracellular sorting and signalling of neurotrophin receptors. EMBO J. 2014, 33:1582-1598.
237. Tischfield M.A., Baris H.N., Wu C., Rudolph G., Van Maldergem L., He W., Chan W.M., Andrews C., Demer J.L., Robertson R.L., et al. Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. Cell 2010, 140:74-87.
238. Tsurusaki Y., Saitoh S., Tomizawa K., Sudo A., Asahina N., Shiraishi H., Ito J., Tanaka H., Doi H., Saitsu H., et al. A DYNC1H1 mutation causes a dominant spinal muscular atrophy with lower extremity predominance. Neurogenetics 2012, 13:327-332.
239. Uchida A., Alami N.H., Brown A. Tight functional coupling of kinesin-1A and dynein motors in the bidirectional transport of neurofilaments. Mol. Biol. Cell 2009, 20:4997-5006.
240. Vale R.D., Reese T.S., Sheetz M.P. Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility. Cell 1985, 42:39-50.
241. van Spronsen M., Mikhaylova M., Lipka J., Schlager M.A., van den Heuvel D.J., Kuijpers M., Wulf P.S., Keijzer N., Demmers J., Kapitein L.C., et al. TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites. Neuron 2013, 77:485-502.
242. Vaughan K.T., Vallee R.B. Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued. J.Cell Biol. 1995, 131:1507-1516.
243. Verhey K.J., Meyer D., Deehan R., Blenis J., Schnapp B.J., Rapoport T.A., Margolis B. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. J.Cell Biol. 2001, 152:959-970.
244. Verhoeven K., De Jonghe P., Coen K., Verpoorten N., Auer-Grumbach M., Kwon J.M., FitzPatrick D., Schmedding E., De Vriendt E., Jacobs A., et al. Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy. Am. J. Hum. Genet. 2003, 72:722-727.
245. Vershinin M., Carter B.C., Razafsky D.S., King S.J., Gross S.P. Multiple-motor based transport and its regulation by Tau. Proc. Natl. Acad. Sci. USA 2007, 104:87-92.
246. Verstreken P., Ly C.V., Venken K.J., Koh T.W., Zhou Y., Bellen H.J. Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions. Neuron 2005, 47:365-378.
247. Wagner O.I., Ascaño J., Tokito M., Leterrier J.F., Janmey P.A., Holzbaur E.L. The interaction of neurofilaments with the microtubule motor cytoplasmic dynein. Mol. Biol. Cell 2004, 15:5092-5100.
248. Wang L., Brown A. Rapid movement of microtubules in axons. Curr. Biol. 2002, 12:1496-1501.
249. Wang L., Brown A. A hereditary spastic paraplegia mutation in kinesin-1A/KIF5A disrupts neurofilament transport. Mol. Neurodegeneration 2010, 5:52.
250. Wang X., Schwarz T.L. The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility. Cell 2009, 136:163-174.
251. Wang L., Ho C.L., Sun D., Liem R.K., Brown A. Rapid movement of axonal neurofilaments interrupted by prolonged pauses. Nat. Cell Biol. 2000, 2:137-141.
252. Watanabe K., Al-Bassam S., Miyazaki Y., Wandless T.J., Webster P., Arnold D.B. Networks of polarized actin filaments in the axon initial segment provide a mechanism for sorting axonal and dendritic proteins. Cell Rep. 2012, 2:1546-1553.
253. Waterman-Storer C.M., Karki S., Holzbaur E.L. The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1). Proc. Natl. Acad. Sci. USA 1995, 92:1634-1638.
254. Weedon M.N., Hastings R., Caswell R., Xie W., Paszkiewicz K., Antoniadi T., Williams M., King C., Greenhalgh L., Newbury-Ecob R., Ellard S. Exome sequencing identifies a DYNC1H1 mutation in a large pedigree with dominant axonal Charcot-Marie-Tooth disease. Am. J. Hum. Genet. 2011, 89:308-312.
255. Weiss P. Neuronal dynamics and axonal flow. 3. Cellulifugal transport of labeled neuroplasm in isolated nerve preparations. Proc. Natl. Acad. Sci. USA 1967, 57:1239-1245.
256. Welte M.A. Bidirectional transport along microtubules. Curr. Biol. 2004, 14:R525-R537.
257. Willemsen M.H., Vissers L.E., Willemsen M.A., van Bon B.W., Kroes T., de Ligt J., de Vries B.B., Schoots J., Lugtenberg D., Hamel B.C., et al. Mutations in DYNC1H1 cause severe intellectual disability with neuronal migration defects. J.Med. Genet. 2012, 49:179-183.
258. Willis D., Li K.W., Zheng J.Q., Chang J.H., Smit A.B., Kelly T., Merianda T.T., Sylvester J., van Minnen J., Twiss J.L. Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons. J.Neurosci. 2005, 25:778-791.
259. Willis D.E., Xu M., Donnelly C.J., Tep C., Kendall M., Erenstheyn M., English A.W., Schanen N.C., Kirn-Safran C.B., Yoon S.O., et al. Axonal localization of transgene mRNA in mature PNS and CNS neurons. J.Neurosci. 2011, 31:14481-14487.
260. Wong Y.C., Holzbaur E.L. The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation. J.Neurosci. 2014, 34:1293-1305.
261. Wong M.Y., Zhou C., Shakiryanova D., Lloyd T.E., Deitcher D.L., Levitan E.S. Neuropeptide delivery to synapses by long-range vesicle circulation and sporadic capture. Cell 2012, 148:1029-1038.
262. Xu K., Zhong G., Zhuang X. Actin, spectrin, and associated proteins form a periodic cytoskeletal structure in axons. Science 2013, 339:452-456.
263. Yabe J.T., Pimenta A., Shea T.B. Kinesin-mediated transport of neurofilament protein oligomers in growing axons. J.Cell Sci. 1999, 112:3799-3814.
264. Yamada K., Andrews C., Chan W.M., McKeown C.A., Magli A., de Berardinis T., Loewenstein A., Lazar M., O'Keefe M., Letson R., et al. Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1). Nat. Genet. 2003, 35:318-321.
265. Yan Y., Brown A. Neurofilament polymer transport in axons. J.Neurosci. 2005, 25:7014-7021.
266. Yeh T.Y., Quintyne N.J., Scipioni B.R., Eckley D.M., Schroer T.A. Dynactin's pointed-end complex is a cargo-targeting module. Mol. Biol. Cell 2012, 23:3827-3837.
267. Yonekawa Y., Harada A., Okada Y., Funakoshi T., Kanai Y., Takei Y., Terada S., Noda T., Hirokawa N. Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice. J.Cell Biol. 1998, 141:431-441.
268. Zala D., Colin E., Rangone H., Liot G., Humbert S., Saudou F. Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons. Hum. Mol. Genet. 2008, 17:3837-3846.
269. Zala D., Hinckelmann M.V., Yu H., Lyra da Cunha M.M., Liot G., Cordelières F.P., Marco S., Saudou F. Vesicular glycolysis provides on-board energy for fast axonal transport. Cell 2013, 152:479-491.
270. Zhang H.L., Eom T., Oleynikov Y., Shenoy S.M., Liebelt D.A., Dictenberg J.B., Singer R.H., Bassell G.J. Neurotrophin-induced transport of a beta-actin mRNP complex increases β-actin levels and stimulates growth cone motility. Neuron 2001, 31:261-275.
271. Zhang J., Yao X., Fischer L., Abenza J.F., Peñalva M.A., Xiang X. The p25 subunit of the dynactin complex is required for dynein-early endosome interaction. J.Cell Biol. 2011, 193:1245-1255.
272. Zhang J., Twelvetrees A.E., Lazarus J.E., Blasier K.R., Yao X., Inamdar N.A., Holzbaur E.L., Pfister K.K., Xiang X. Establishing a novel knock-in mouse line for studying neuronal cytoplasmic dynein under normal and pathologic conditions. Cytoskeleton (Hoboken) 2013, 70:215-227.
273. Zhao C., Takita J., Tanaka Y., Setou M., Nakagawa T., Takeda S., Yang H.W., Terada S., Nakata T., Takei Y., et al. Charcot-Marie-Tooth Disease Type 2A caused by mutation in a microtubule motor KIF1Bβ. Cell 2001, 105:587-597.