메뉴 건너뛰기




Volumn 15, Issue 1, 2014, Pages 32-42

Axon-soma communication in neuronal injury

Author keywords

[No Author keywords available]

Indexed keywords

DYNEIN ADENOSINE TRIPHOSPHATASE; KARYOPHERIN; MITOGEN ACTIVATED PROTEIN KINASE; MOLECULAR MOTOR; STRESS ACTIVATED PROTEIN KINASE;

EID: 84890980878     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn3609     Document Type: Review
Times cited : (226)

References (141)
  • 1
    • 36049044386 scopus 로고    scopus 로고
    • Message in a bottle: Long-range retrograde signaling in the nervous system
    • Ibanez, C. F. Message in a bottle: long-range retrograde signaling in the nervous system. Trends Cell Biol. 17, 519-528 (2007).
    • (2007) Trends Cell Biol , vol.17 , pp. 519-528
    • Ibanez, C.F.1
  • 2
    • 84875437096 scopus 로고    scopus 로고
    • Long-distance retrograde neurotrophic factor signalling in neurons
    • Harrington, A. W. & Ginty, D. D. Long-distance retrograde neurotrophic factor signalling in neurons. Nature Rev. Neurosci. 14, 177-187 (2013).
    • (2013) Nature Rev. Neurosci , vol.14 , pp. 177-187
    • Harrington, A.W.1    Ginty, D.D.2
  • 3
    • 84875443717 scopus 로고    scopus 로고
    • Axonal transport deficits and neurodegenerative diseases
    • Millecamps, S. & Julien, J. P. Axonal transport deficits and neurodegenerative diseases. Nature Rev. Neurosci. 14, 161-176 (2013).
    • (2013) Nature Rev. Neurosci , vol.14 , pp. 161-176
    • Millecamps, S.1    Julien, J.P.2
  • 5
    • 84887405760 scopus 로고    scopus 로고
    • Neurite pruning and neuronal cell death: Spatial regulation of shared destruction programs
    • Maor-Nof, M. & Yaron, A. Neurite pruning and neuronal cell death: spatial regulation of shared destruction programs. Curr. Opin. Neurobiol. 23, 990-996 (2013).
    • (2013) Curr. Opin. Neurobiol , vol.23 , pp. 990-996
    • Maor-Nof, M.1    Yaron, A.2
  • 6
    • 84863012284 scopus 로고    scopus 로고
    • Axon degeneration: Molecular mechanisms of a self-destruction pathway
    • Wang, J. T., Medress, Z. A. & Barres, B. A. Axon degeneration: molecular mechanisms of a self-destruction pathway. J. Cell Biol. 196, 7-18 (2012).
    • (2012) J. Cell Biol , vol.196 , pp. 7-18
    • Wang, J.T.1    Medress, Z.A.2    Barres, B.A.3
  • 7
    • 0014967278 scopus 로고
    • What is the signal for chromatolysis?
    • Cragg, B. G. What is the signal for chromatolysis? Brain Res. 23, 1-21 (1970).
    • (1970) Brain Res , vol.23 , pp. 1-21
    • Cragg, B.G.1
  • 8
    • 0015197354 scopus 로고
    • The axon reaction: A review of the principal features of perikaryal responses to axon injury
    • Lieberman, A. R. The axon reaction: a review of the principal features of perikaryal responses to axon injury. Int. Rev. Neurobiol. 14, 49-124 (1971).
    • (1971) Int. Rev. Neurobiol , vol.14 , pp. 49-124
    • Lieberman, A.R.1
  • 10
    • 77950860161 scopus 로고    scopus 로고
    • Retrograde signaling in axonal regeneration
    • Rishal, I. & Fainzilber, M. Retrograde signaling in axonal regeneration. Exp. Neurol. 223, 5-10 (2010).
    • (2010) Exp. Neurol , vol.223 , pp. 5-10
    • Rishal, I.1    Fainzilber, M.2
  • 12
    • 84862766586 scopus 로고    scopus 로고
    • The role of Nogo-A in axonal plasticity, regrowth and repair
    • Pernet, V. & Schwab, M. E. The role of Nogo-A in axonal plasticity, regrowth and repair. Cell Tissue Res. 349, 97-104 (2012).
    • (2012) Cell Tissue Res , vol.349 , pp. 97-104
    • Pernet, V.1    Schwab, M.E.2
  • 13
    • 33847094740 scopus 로고    scopus 로고
    • Regulation of intrinsic neuronal properties for axon growth and regeneration
    • Rossi, F., Gianola, S. & Corvetti, L. Regulation of intrinsic neuronal properties for axon growth and regeneration. Prog. Neurobiol. 81, 1-28 (2007).
    • (2007) Prog. Neurobiol , vol.81 , pp. 1-28
    • Rossi, F.1    Gianola, S.2    Corvetti, L.3
  • 14
    • 0030203658 scopus 로고    scopus 로고
    • Priming events and retrograde injury signals. A new perspective on the cellular and molecular biology of nerve regeneration
    • Ambron, R. T. & Walters, E. T. Priming events and retrograde injury signals. A new perspective on the cellular and molecular biology of nerve regeneration. Mol. Neurobiol. 13, 61-79 (1996).
    • (1996) Mol. Neurobiol , vol.13 , pp. 61-79
    • Ambron, R.T.1    Walters, E.T.2
  • 15
    • 0029569123 scopus 로고
    • Axotomy induces a transient and localized elevation of the free intracellular calcium concentration to the millimolar range
    • Ziv, N. E. & Spira, M. E. Axotomy induces a transient and localized elevation of the free intracellular calcium concentration to the millimolar range. J. Neurophysiol. 74, 2625-2637 (1995).
    • (1995) J. Neurophysiol , vol.74 , pp. 2625-2637
    • Ziv, N.E.1    Spira, M.E.2
  • 16
    • 10044238913 scopus 로고    scopus 로고
    • Acute physiological response of mammalian central neurons to axotomy: Ionic regulation and electrical activity
    • Mandolesi, G., Madeddu, F., Bozzi, Y., Maffei, L. & Ratto, G. M. Acute physiological response of mammalian central neurons to axotomy: ionic regulation and electrical activity. FASEB J. 18, 1934-1936 (2004).
    • (2004) FASEB J. , vol.18 , pp. 1934-1936
    • Mandolesi, G.1    Madeddu, F.2    Bozzi, Y.3    Maffei, L.4    Ratto, G.M.5
  • 17
    • 0035869473 scopus 로고    scopus 로고
    • Traumatic axonal injury induces calcium influx modulated by tetrodotoxin-sensitive sodium channels
    • Wolf, J. A., Stys, P. K., Lusardi, T., Meaney, D. & Smith, D. H. Traumatic axonal injury induces calcium influx modulated by tetrodotoxin- sensitive sodium channels. J. Neurosci. 21, 1923-1930 (2001).
    • (2001) J. Neurosci , vol.21 , pp. 1923-1930
    • Wolf, J.A.1    Stys, P.K.2    Lusardi, T.3    Meaney, D.4    Smith, D.H.5
  • 18
    • 77749313490 scopus 로고    scopus 로고
    • Calcium and cyclic amp promote axonal regeneration in caenorhabditis elegans and require dlk-1 kinase
    • Ghosh-Roy, A., Wu, Z., Goncharov, A., Jin, Y. & Chisholm, A. D. Calcium and cyclic AMP promote axonal regeneration in Caenorhabditis elegans and require DLK-1 kinase. J. Neurosci. 30, 3175-3183 (2010).
    • (2010) J. Neurosci , vol.30 , pp. 3175-3183
    • Ghosh-Roy, A.1    Wu, Z.2    Goncharov, A.3    Jin, Y.4    Chisholm, A.D.5
  • 19
    • 84857371961 scopus 로고    scopus 로고
    • Assembly of a new growth cone after axotomy: The precursor to axon regeneration
    • Bradke, F., Fawcett, J. W. & Spira, M. E. Assembly of a new growth cone after axotomy: the precursor to axon regeneration. Nature Rev. Neurosci. 13, 183-193 (2012).
    • (2012) Nature Rev. Neurosci , vol.13 , pp. 183-193
    • Bradke, F.1    Fawcett, J.W.2    Spira, M.E.3
  • 20
    • 77950518136 scopus 로고    scopus 로고
    • Mechanisms of axonal injury: Internodal nanocomplexes and calcium deregulation
    • Stirling, D. P. & Stys, P. K. Mechanisms of axonal injury: internodal nanocomplexes and calcium deregulation. Trends Mol. Med. 16, 160-170 (2010).
    • (2010) Trends Mol. Med , vol.16 , pp. 160-170
    • Stirling, D.P.1    Stys, P.K.2
  • 21
    • 0032103443 scopus 로고    scopus 로고
    • Real time imaging of calcium-induced localized proteolytic activity after axotomy and its relation to growth cone formation
    • Gitler, D. & Spira, M. E. Real time imaging of calcium-induced localized proteolytic activity after axotomy and its relation to growth cone formation. Neuron 20, 1123-1135 (1998).
    • (1998) Neuron , vol.20 , pp. 1123-1135
    • Gitler, D.1    Spira, M.E.2
  • 22
    • 0032798117 scopus 로고    scopus 로고
    • Resealing of transected myelinated mammalian axons in vivo: Evidence for involvement of calpain
    • Howard, M. J., David, G. & Barrett, J. N. Resealing of transected myelinated mammalian axons in vivo: evidence for involvement of calpain. Neuroscience 93, 807-815 (1999).
    • (1999) Neuroscience , vol.93 , pp. 807-815
    • Howard, M.J.1    David, G.2    Barrett, J.N.3
  • 23
    • 0035130433 scopus 로고    scopus 로고
    • Axon resealing following transection takes longer in central axons than in peripheral axons: Implications for axonal regeneration
    • Ahmed, F. A., Ingoglia, N. A. & Sharma, S. C. Axon resealing following transection takes longer in central axons than in peripheral axons: implications for axonal regeneration. Exp. Neurol. 167, 451-455 (2001).
    • (2001) Exp. Neurol , vol.167 , pp. 451-455
    • Ahmed, F.A.1    Ingoglia, N.A.2    Sharma, S.C.3
  • 24
    • 77955416137 scopus 로고    scopus 로고
    • Electrical activity suppresses axon growth through Cav1.2 channels in adult primary sensory neurons
    • Enes, J. et al. Electrical activity suppresses axon growth through Cav1.2 channels in adult primary sensory neurons. Curr. Biol. 20, 1154-1164 (2010).
    • (2010) Curr. Biol , vol.20 , pp. 1154-1164
    • Enes, J.1
  • 25
    • 79952622183 scopus 로고    scopus 로고
    • Subtype-specific reduction of voltage-gated calcium current in medium-sized dorsal root ganglion neurons after painful peripheral nerve injury
    • McCallum, J. B., Wu, H. E., Tang, Q., Kwok, W. M. & Hogan, Q. H. Subtype-specific reduction of voltage-gated calcium current in medium-sized dorsal root ganglion neurons after painful peripheral nerve injury. Neuroscience 179, 244-255 (2011).
    • (2011) Neuroscience , vol.179 , pp. 244-255
    • McCallum, J.B.1    Wu, H.E.2    Tang, Q.3    Kwok, W.M.4    Hogan, Q.H.5
  • 26
    • 2442662940 scopus 로고    scopus 로고
    • Traumatic axonal injury induces proteolytic cleavage of the voltage-gated sodium channels modulated by tetrodotoxin and protease inhibitors
    • Iwata, A. et al. Traumatic axonal injury induces proteolytic cleavage of the voltage-gated sodium channels modulated by tetrodotoxin and protease inhibitors. J. Neurosci. 24, 4605-4613 (2004).
    • (2004) J. Neurosci , vol.24 , pp. 4605-4613
    • Iwata, A.1
  • 27
    • 34548714102 scopus 로고    scopus 로고
    • Na+/Ca2+ exchangers: Three mammalian gene families control Ca2+ transport
    • Lytton, J. Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport. Biochem. J. 406, 365-382 (2007).
    • (2007) Biochem. J. , vol.406 , pp. 365-382
    • Lytton, J.1
  • 28
    • 79952394104 scopus 로고    scopus 로고
    • Store-operated Ca2+ entry in sensory neurons: Functional role and the effect of painful nerve injury
    • Gemes, G. et al. Store-operated Ca2+ entry in sensory neurons: functional role and the effect of painful nerve injury. J. Neurosci. 31, 3536-3549 (2011).
    • (2011) J. Neurosci , vol.31 , pp. 3536-3549
    • Gemes, G.1
  • 29
    • 68249154947 scopus 로고    scopus 로고
    • Axotomy depletes intracellular calcium stores in primary sensory neurons
    • Rigaud, M. et al. Axotomy depletes intracellular calcium stores in primary sensory neurons. Anesthesiology 111, 381-392 (2009).
    • (2009) Anesthesiology , vol.111 , pp. 381-392
    • Rigaud, M.1
  • 30
    • 84887959502 scopus 로고    scopus 로고
    • Injury-induced HDAC5 nuclear export is essential for axon regeneration
    • Cho, Y., Sloutsky, R., Naegle, K. M. & Cavalli, V. Injury-induced HDAC5 nuclear export is essential for axon regeneration. Cell 155, 894-908 (2013). In this article, the authors propose that injury-induced early calcium waves along the axon elicit HDAC5 export from the nucleus, thereby causing epigenetic changes that prime the system for an efficient response.
    • (2013) Cell , vol.155 , pp. 894-908
    • Cho, Y.1    Sloutsky, R.2    Naegle, K.M.3    Cavalli, V.4
  • 31
    • 59049099831 scopus 로고    scopus 로고
    • A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins
    • Merianda, T. T. et al. A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins. Mol. Cell Neurosci. 40, 128-142 (2009).
    • (2009) Mol. Cell Neurosci , vol.40 , pp. 128-142
    • Merianda, T.T.1
  • 32
    • 69049116237 scopus 로고    scopus 로고
    • Calpain mediates proteolysis of the voltage-gated sodium channel α-subunit
    • von Reyn, C. R. et al. Calpain mediates proteolysis of the voltage-gated sodium channel α-subunit. J. Neurosci. 29, 10350-10356 (2009).
    • (2009) J. Neurosci , vol.29 , pp. 10350-10356
    • Von Reyn, C.R.1
  • 33
    • 84856583036 scopus 로고    scopus 로고
    • Calpain in the CNS: From synaptic function to neurotoxicity
    • Liu, J., Liu, M. C. & Wang, K. K. Calpain in the CNS: from synaptic function to neurotoxicity. Sci. Signal. 1, re1 (2008).
    • (2008) Sci. Signal , vol.1
    • Liu, J.1    Liu, M.C.2    Wang, K.K.3
  • 34
    • 80054793380 scopus 로고    scopus 로고
    • Neuronal activity-regulated gene transcription in synapse development and cognitive function
    • West, A. E. & Greenberg, M. E. Neuronal activity-regulated gene transcription in synapse development and cognitive function. Cold Spring Harb. Perspect. Biol. 3, a005744 (2011).
    • (2011) Cold Spring Harb. Perspect. Biol , vol.3
    • West, A.E.1    Greenberg, M.E.2
  • 35
    • 77956626072 scopus 로고    scopus 로고
    • Signaling to transcription networks in the neuronal retrograde injury response
    • Michaelevski, I. et al. Signaling to transcription networks in the neuronal retrograde injury response. Sci. Signal. 3, ra53 (2010).
    • (2010) Sci. Signal , vol.3
    • Michaelevski, I.1
  • 36
    • 73349143672 scopus 로고    scopus 로고
    • HDAC6 is a target for protection and regeneration following injury in the nervous system
    • Rivieccio, M. A. et al. HDAC6 is a target for protection and regeneration following injury in the nervous system. Proc. Natl Acad. Sci. USA 106, 19599-19604 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 19599-19604
    • Rivieccio, M.A.1
  • 37
    • 77955709610 scopus 로고    scopus 로고
    • HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation
    • Gaub, P. et al. HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation. Cell Death Differ. 17, 1392-1408 (2010).
    • (2010) Cell Death Differ , vol.17 , pp. 1392-1408
    • Gaub, P.1
  • 38
    • 84864147535 scopus 로고    scopus 로고
    • HDAC5 is a novel injury-regulated tubulin deacetylase controlling axon regeneration
    • Cho, Y. & Cavalli, V. HDAC5 is a novel injury-regulated tubulin deacetylase controlling axon regeneration. EMBO J. 31, 3063-3078 (2012).
    • (2012) EMBO J. , vol.31 , pp. 3063-3078
    • Cho, Y.1    Cavalli, V.2
  • 39
    • 77954835104 scopus 로고    scopus 로고
    • Local and remote growth factor effects after primate spinal cord injury
    • Brock, J. H. et al. Local and remote growth factor effects after primate spinal cord injury. J. Neurosci. 30, 9728-9737 (2010).
    • (2010) J. Neurosci , vol.30 , pp. 9728-9737
    • Brock, J.H.1
  • 40
    • 84856791562 scopus 로고    scopus 로고
    • Gp130 cytokines are positive signals triggering changes in gene expression and axon outgrowth in peripheral neurons following injury
    • Zigmond, R. E. gp130 cytokines are positive signals triggering changes in gene expression and axon outgrowth in peripheral neurons following injury. Front. Mol. Neurosci. 4, 62 (2011).
    • (2011) Front. Mol. Neurosci , vol.4 , Issue.62
    • Zigmond, R.E.1
  • 41
    • 77951778474 scopus 로고    scopus 로고
    • Axonal transport proteomics reveals mobilization of translation machinery to the lesion site in injured sciatic nerve
    • Michaelevski, I., Medzihradszky, K. F., Lynn, A., Burlingame, A. L. & Fainzilber, M. Axonal transport proteomics reveals mobilization of translation machinery to the lesion site in injured sciatic nerve. Mol. Cell Proteom. 9, 976-987 (2010).
    • (2010) Mol. Cell Proteom , vol.9 , pp. 976-987
    • Michaelevski, I.1    Medzihradszky, K.F.2    Lynn, A.3    Burlingame, A.L.4    Fainzilber, M.5
  • 42
    • 0035881379 scopus 로고    scopus 로고
    • Anterograde and retrograde transport of active extracellular signal-related kinase 1 (erk1) in the ligated rat sciatic nerve
    • Reynolds, A. J., Hendry, I. A. & Bartlett, S. E. Anterograde and retrograde transport of active extracellular signal-related kinase 1 (ERK1) in the ligated rat sciatic nerve. Neuroscience 105, 761-771 (2001).
    • (2001) Neuroscience , vol.105 , pp. 761-771
    • Reynolds, A.J.1    Hendry, I.A.2    Bartlett, S.E.3
  • 43
    • 0035079172 scopus 로고    scopus 로고
    • Risk-1: A novel mapk homologue in axoplasm that is activated and retrogradely transported after nerve injury
    • Sung, Y. J., Povelones, M. & Ambron, R. T. RISK-1: a novel MAPK homologue in axoplasm that is activated and retrogradely transported after nerve injury. J. Neurobiol. 47, 67-79 (2001).
    • (2001) J. Neurobiol , vol.47 , pp. 67-79
    • Sung, Y.J.1    Povelones, M.2    Ambron, R.T.3
  • 44
    • 4444325794 scopus 로고    scopus 로고
    • A neuronal isoform of protein kinase G couples mitogen-activated protein kinase nuclear import to axotomy-induced long-term hyperexcitability in Aplysia sensory neurons
    • Sung, Y. J., Walters, E. T. & Ambron, R. T. A neuronal isoform of protein kinase G couples mitogen-activated protein kinase nuclear import to axotomy-induced long-term hyperexcitability in Aplysia sensory neurons. J. Neurosci. 24, 7583-7595 (2004).
    • (2004) J. Neurosci , vol.24 , pp. 7583-7595
    • Sung, Y.J.1    Walters, E.T.2    Ambron, R.T.3
  • 45
    • 19444385804 scopus 로고    scopus 로고
    • Retrograde axonal transport of JNK signaling molecules influence injury induced nuclear changes in p-c-Jun and ATF3 in adult rat sensory neurons
    • Lindwall, C. & Kanje, M. Retrograde axonal transport of JNK signaling molecules influence injury induced nuclear changes in p-c-Jun and ATF3 in adult rat sensory neurons. Mol. Cell Neurosci. 29, 269-282 (2005).
    • (2005) Mol. Cell Neurosci , vol.29 , pp. 269-282
    • Lindwall, C.1    Kanje, M.2
  • 46
    • 8144231119 scopus 로고    scopus 로고
    • The role of MAP kinases in rapid gene induction after lesioning of the rat sciatic nerve
    • Zrouri, H., Le Goascogne, C., Li, W. W., Pierre, M. & Courtin, F. The role of MAP kinases in rapid gene induction after lesioning of the rat sciatic nerve. Eur. J. Neurosci. 20, 1811-1818 (2004).
    • (2004) Eur. J. Neurosci , vol.20 , pp. 1811-1818
    • Zrouri, H.1    Le Goascogne, C.2    Li, W.W.3    Pierre, M.4    Courtin, F.5
  • 47
    • 14644404885 scopus 로고    scopus 로고
    • Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve
    • Perlson, E. et al. Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve. Neuron 45, 715-726 (2005).
    • (2005) Neuron , vol.45 , pp. 715-726
    • Perlson, E.1
  • 48
    • 33845335809 scopus 로고    scopus 로고
    • Mst3b, a purine-sensitive Ste20-like protein kinase, regulates axon outgrowth
    • Irwin, N., Li, Y. M., O'Toole, J. E. & Benowitz, L. I. Mst3b, a purine-sensitive Ste20-like protein kinase, regulates axon outgrowth. Proc. Natl Acad. Sci. USA 103, 18320-18325 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 18320-18325
    • Irwin, N.1    Li, Y.M.2    O'Toole, J.E.3    Benowitz, L.I.4
  • 49
    • 14744273901 scopus 로고    scopus 로고
    • Sunday driver links axonal transport to damage signaling
    • Cavalli, V., Kujala, P., Klumperman, J. & Goldstein, L. S. Sunday Driver links axonal transport to damage signaling. J. Cell Biol. 168, 775-787 (2005).
    • (2005) J. Cell Biol , vol.168 , pp. 775-787
    • Cavalli, V.1    Kujala, P.2    Klumperman, J.3    Goldstein, L.S.4
  • 50
    • 84874789461 scopus 로고    scopus 로고
    • JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes
    • Drerup, C. M. & Nechiporuk, A. V. JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes. PLoS Genet. 9, e1003303 (2013).
    • (2013) PLoS Genet , vol.9
    • Drerup, C.M.1    Nechiporuk, A.V.2
  • 51
    • 84859779183 scopus 로고    scopus 로고
    • Neuronal c-Jun is required for successful axonal regeneration, but the effects of phosphorylation of its N-terminus are moderate
    • Ruff, C. A. et al. Neuronal c-Jun is required for successful axonal regeneration, but the effects of phosphorylation of its N-terminus are moderate. J. Neurochem. 121, 607-618 (2012).
    • (2012) J. Neurochem , vol.121 , pp. 607-618
    • Ruff, C.A.1
  • 52
    • 68549121208 scopus 로고    scopus 로고
    • A switch in retrograde signaling from survival to stress in rapid-onset neurodegeneration
    • Perlson, E. et al. A switch in retrograde signaling from survival to stress in rapid-onset neurodegeneration. J. Neurosci. 29, 9903-9917 (2009). This study shows how a switch in the cargoes transported by retrograde motors can lead to drastically different biological outcomes for the neuron.
    • (2009) J. Neurosci , vol.29 , pp. 9903-9917
    • Perlson, E.1
  • 53
    • 67349185058 scopus 로고    scopus 로고
    • Specific activities of individual c-Jun N-terminal kinases in the brain
    • Haeusgen, W., Boehm, R., Zhao, Y., Herdegen, T. & Waetzig, V. Specific activities of individual c-Jun N-terminal kinases in the brain. Neuroscience 161, 951-959 (2009).
    • (2009) Neuroscience , vol.161 , pp. 951-959
    • Haeusgen, W.1    Boehm, R.2    Zhao, Y.3    Herdegen, T.4    Waetzig, V.5
  • 54
    • 50349092257 scopus 로고    scopus 로고
    • All JNKs can kill, but nuclear localization is critical for neuronal death
    • Bjorkblom, B. et al. All JNKs can kill, but nuclear localization is critical for neuronal death. J. Biol. Chem. 283, 19704-19713 (2008).
    • (2008) J. Biol. Chem , vol.283 , pp. 19704-19713
    • Bjorkblom, B.1
  • 55
    • 59849116455 scopus 로고    scopus 로고
    • Axon regeneration requires a conserved MAP kinase pathway
    • Hammarlund, M., Nix, P., Hauth, L., Jorgensen, E. M. & Bastiani, M. Axon regeneration requires a conserved MAP kinase pathway. Science 323, 802-806 (2009).
    • (2009) Science , vol.323 , pp. 802-806
    • Hammarlund, M.1    Nix, P.2    Hauth, L.3    Jorgensen, E.M.4    Bastiani, M.5
  • 56
    • 69449105574 scopus 로고    scopus 로고
    • The DLK-1 kinase promotes mRNA stability and local translation in C. Elegans synapses and axon regeneration
    • Yan, D., Wu, Z., Chisholm, A. D. & Jin, Y. The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration. Cell 138, 1005-1018 (2009).
    • (2009) Cell , vol.138 , pp. 1005-1018
    • Yan, D.1    Wu, Z.2    Chisholm, A.D.3    Jin, Y.4
  • 57
    • 77957728785 scopus 로고    scopus 로고
    • Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury
    • Xiong, X. et al. Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury. J. Cell Biol. 191, 211-223 (2010).
    • (2010) J. Cell Biol , vol.191 , pp. 211-223
    • Xiong, X.1
  • 58
    • 84880763435 scopus 로고    scopus 로고
    • Independent pathways downstream of the Wnd/DLK MAPKKK regulate synaptic structure, axonal transport, and injury signaling
    • Klinedinst, S., Wang, X., Xiong, X., Haenfler, J. M. & Collins, C. A. Independent pathways downstream of the Wnd/DLK MAPKKK regulate synaptic structure, axonal transport, and injury signaling. J. Neurosci. 33, 12764-12778 (2013).
    • (2013) J. Neurosci , vol.33 , pp. 12764-12778
    • Klinedinst, S.1    Wang, X.2    Xiong, X.3    Haenfler, J.M.4    Collins, C.A.5
  • 59
    • 65049090902 scopus 로고    scopus 로고
    • Impaired regenerative response of primary sensory neurons in ZPK/DLK gene-trap mice
    • Itoh, A., Horiuchi, M., Bannerman, P., Pleasure, D. & Itoh, T. Impaired regenerative response of primary sensory neurons in ZPK/DLK gene-trap mice. Biochem. Biophys. Res. Commun. 383, 258-262 (2009).
    • (2009) Biochem. Biophys. Res. Commun , vol.383 , pp. 258-262
    • Itoh, A.1    Horiuchi, M.2    Bannerman, P.3    Pleasure, D.4    Itoh, T.5
  • 60
    • 84862687092 scopus 로고    scopus 로고
    • Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration
    • Shin, J. E. et al. Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration. Neuron 74, 1015-1022 (2012). In this study, the authors demonstrate that DLK is required for JNK-dependent retrograde injury signalling and also show that it regulates other retrograde cargoes.
    • (2012) Neuron , vol.74 , pp. 1015-1022
    • Shin, J.E.1
  • 61
    • 2642535306 scopus 로고    scopus 로고
    • STAT3 phosphorylation in injured axons before sensory and motor neuron nuclei: Potential role for STAT3 as a retrograde signaling transcription factor
    • Lee, N., Neitzel, K. L., Devlin, B. K. & MacLennan, A. J. STAT3 phosphorylation in injured axons before sensory and motor neuron nuclei: potential role for STAT3 as a retrograde signaling transcription factor. J. Comp. Neurol. 474, 535-545 (2004).
    • (2004) J. Comp. Neurol , vol.474 , pp. 535-545
    • Lee, N.1    Neitzel, K.L.2    Devlin, B.K.3    MacLennan, A.J.4
  • 62
    • 14044250276 scopus 로고    scopus 로고
    • Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation
    • Qiu, J., Cafferty, W. B., McMahon, S. B. & Thompson, S. W. Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation. J. Neurosci. 25, 1645-1653 (2005).
    • (2005) J. Neurosci , vol.25 , pp. 1645-1653
    • Qiu, J.1    Cafferty, W.B.2    McMahon, S.B.3    Thompson, S.W.4
  • 63
    • 84858799332 scopus 로고    scopus 로고
    • Axonal transcription factors signal retrogradely in lesioned peripheral nerve
    • Ben-Yaakov, K. et al. Axonal transcription factors signal retrogradely in lesioned peripheral nerve. EMBO J. 31, 1350-1363 (2012). This study shows that transcription factors are retrogradely transported by the importin-dynein complex in axons to participate in retrograde injury signalling.
    • (2012) EMBO J. , vol.31 , pp. 1350-1363
    • Ben-Yaakov, K.1
  • 64
    • 0034954603 scopus 로고    scopus 로고
    • The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis
    • Xu, Z., Maroney, A. C., Dobrzanski, P., Kukekov, N. V. & Greene, L. A. The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. Mol. Cell. Biol. 21, 4713-4724 (2001).
    • (2001) Mol. Cell. Biol , vol.21 , pp. 4713-4724
    • Xu, Z.1    Maroney, A.C.2    Dobrzanski, P.3    Kukekov, N.V.4    Greene, L.A.5
  • 65
    • 79956318147 scopus 로고    scopus 로고
    • ZPK/DLK, a mitogen-activated protein kinase kinase kinase, is a critical mediator of programmed cell death of motoneurons
    • Itoh, A. et al. ZPK/DLK, a mitogen-activated protein kinase kinase kinase, is a critical mediator of programmed cell death of motoneurons. J. Neurosci. 31, 7223-7228 (2011).
    • (2011) J. Neurosci , vol.31 , pp. 7223-7228
    • Itoh, A.1
  • 66
    • 84861537887 scopus 로고    scopus 로고
    • The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans
    • Pinan-Lucarre, B. et al. The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans. PLoS Biol. 10, e1001331 (2012).
    • (2012) PLoS Biol , vol.10
    • Pinan-Lucarre, B.1
  • 67
    • 84874601803 scopus 로고    scopus 로고
    • DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury
    • Watkins, T. A. et al. DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. Proc. Natl Acad. Sci. USA 110, 4039-4044 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 4039-4044
    • Watkins, T.A.1
  • 68
    • 84874629422 scopus 로고    scopus 로고
    • Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death
    • Welsbie, D. S. et al. Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Proc. Natl Acad. Sci. USA 110, 4045-4050 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 4045-4050
    • Welsbie, D.S.1
  • 69
    • 84884180452 scopus 로고    scopus 로고
    • JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis
    • Huntwork-Rodriguez, S. et al. JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis. J. Cell Biol. 202, 747-763 (2013).
    • (2013) J. Cell Biol , vol.202 , pp. 747-763
    • Huntwork-Rodriguez, S.1
  • 70
    • 84868652830 scopus 로고    scopus 로고
    • Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform
    • Yan, D. & Jin, Y. Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform. Neuron 76, 534-548 (2012).
    • (2012) Neuron , vol.76 , pp. 534-548
    • Yan, D.1    Jin, Y.2
  • 71
    • 0029046160 scopus 로고
    • Axoplasm enriched in a protein mobilized by nerve injury induces memory-like alterations in Aplysia neurons
    • Ambron, R. T., Dulin, M. F., Zhang, X. P., Schmied, R. & Walters, E. T. Axoplasm enriched in a protein mobilized by nerve injury induces memory-like alterations in Aplysia neurons. J. Neurosci. 15, 3440-3446 (1995).
    • (1995) J. Neurosci , vol.15 , pp. 3440-3446
    • Ambron, R.T.1    Dulin, M.F.2    Zhang, X.P.3    Schmied, R.4    Walters, E.T.5
  • 72
    • 67649441084 scopus 로고    scopus 로고
    • Nuclear transport factors in neuronal function
    • Perry, R. B. & Fainzilber, M. Nuclear transport factors in neuronal function. Semin. Cell Dev. Biol. 20, 600-606 (2009).
    • (2009) Semin. Cell Dev. Biol , vol.20 , pp. 600-606
    • Perry, R.B.1    Fainzilber, M.2
  • 73
    • 9144273965 scopus 로고    scopus 로고
    • Axoplasmic importins enable retrograde injury signaling in lesioned nerve
    • Hanz, S. et al. Axoplasmic importins enable retrograde injury signaling in lesioned nerve. Neuron 40, 1095-1104 (2003).
    • (2003) Neuron , vol.40 , pp. 1095-1104
    • Hanz, S.1
  • 74
    • 2642548912 scopus 로고    scopus 로고
    • Differential proteomics reveals multiple components in retrogradely transported axoplasm after nerve injury
    • Perlson, E. et al. Differential proteomics reveals multiple components in retrogradely transported axoplasm after nerve injury. Mol. Cell Proteom. 3, 510-520 (2004).
    • (2004) Mol. Cell Proteom , vol.3 , pp. 510-520
    • Perlson, E.1
  • 75
    • 52049108218 scopus 로고    scopus 로고
    • Identification and characterization of a general nuclear translocation signal in signaling proteins
    • Chuderland, D., Konson, A. & Seger, R. Identification and characterization of a general nuclear translocation signal in signaling proteins. Mol. Cell 31, 850-861 (2008).
    • (2008) Mol. Cell , vol.31 , pp. 850-861
    • Chuderland, D.1    Konson, A.2    Seger, R.3
  • 76
    • 33751116969 scopus 로고    scopus 로고
    • Vimentin binding to phosphorylated Erk sterically hinders enzymatic dephosphorylation of the kinase
    • Perlson, E. et al. Vimentin binding to phosphorylated Erk sterically hinders enzymatic dephosphorylation of the kinase. J. Mol. Biol. 364, 938-944 (2006).
    • (2006) J. Mol. Biol , vol.364 , pp. 938-944
    • Perlson, E.1
  • 77
    • 84874773318 scopus 로고    scopus 로고
    • Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus
    • Karpova, A. et al. Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus. Cell 152, 1119-1133 (2013). This intriguing study proposes a mechanism for combinatorial encoding of the origin of a distant signal to the nucleus.
    • (2013) Cell , vol.152 , pp. 1119-1133
    • Karpova, A.1
  • 78
    • 39549091696 scopus 로고    scopus 로고
    • Transcription factor NF-κB is transported to the nucleus via cytoplasmic dynein/dynactin motor complex in hippocampal neurons
    • Mikenberg, I., Widera, D., Kaus, A., Kaltschmidt, B. & Kaltschmidt, C. Transcription factor NF-κB is transported to the nucleus via cytoplasmic dynein/dynactin motor complex in hippocampal neurons. PLoS ONE 2, e589 (2007).
    • (2007) PLoS ONE , vol.2
    • Mikenberg, I.1    Widera, D.2    Kaus, A.3    Kaltschmidt, B.4    Kaltschmidt, C.5
  • 79
    • 55949129446 scopus 로고    scopus 로고
    • Importin-mediated retrograde transport of CREB2 from distal processes to the nucleus in neurons
    • Lai, K. O., Zhao, Y., Ch'ng, T. H. & Martin, K. C. Importin-mediated retrograde transport of CREB2 from distal processes to the nucleus in neurons. Proc. Natl Acad. Sci. USA 105, 17175-17180 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 17175-17180
    • Lai, K.O.1    Zhao, Y.2    Ch'Ng, T.H.3    Martin, K.C.4
  • 80
    • 62449332148 scopus 로고    scopus 로고
    • Stimulated nuclear translocation of NF-κB and shuttling differentially depend on dynein and the dynactin complex
    • Shrum, C. K., Defrancisco, D. & Meffert, M. K. Stimulated nuclear translocation of NF-κB and shuttling differentially depend on dynein and the dynactin complex. Proc. Natl Acad. Sci. USA 106, 2647-2652 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 2647-2652
    • Shrum, C.K.1    Defrancisco, D.2    Meffert, M.K.3
  • 81
    • 38849124121 scopus 로고    scopus 로고
    • Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival
    • Cox, L. J., Hengst, U., Gurskaya, N. G., Lukyanov, K. A. & Jaffrey, S. R. Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival. Nature Cell Biol. 10, 149-159 (2008).
    • (2008) Nature Cell Biol , vol.10 , pp. 149-159
    • Cox, L.J.1    Hengst, U.2    Gurskaya, N.G.3    Lukyanov, K.A.4    Jaffrey, S.R.5
  • 82
    • 84859648537 scopus 로고    scopus 로고
    • Intra-axonal translation of SMAD1/5/8 mediates retrograde regulation of trigeminal ganglia subtype specification
    • Ji, S. J. & Jaffrey, S. R. Intra-axonal translation of SMAD1/5/8 mediates retrograde regulation of trigeminal ganglia subtype specification. Neuron 74, 95-107 (2012).
    • (2012) Neuron , vol.74 , pp. 95-107
    • Ji, S.J.1    Jaffrey, S.R.2
  • 83
    • 84869136353 scopus 로고    scopus 로고
    • Local axonal function of STAT3 rescues axon degeneration in the pmn model of motoneuron disease
    • Selvaraj, B. T., Frank, N., Bender, F. L., Asan, E. & Sendtner, M. Local axonal function of STAT3 rescues axon degeneration in the pmn model of motoneuron disease. J. Cell Biol. 199, 437-451 (2012).
    • (2012) J. Cell Biol , vol.199 , pp. 437-451
    • Selvaraj, B.T.1    Frank, N.2    Bender, F.L.3    Asan, E.4    Sendtner, M.5
  • 84
    • 47749146105 scopus 로고    scopus 로고
    • Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve
    • Yudin, D. et al. Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve. Neuron 59, 241-252 (2008).
    • (2008) Neuron , vol.59 , pp. 241-252
    • Yudin, D.1
  • 85
    • 66149101014 scopus 로고    scopus 로고
    • Ran on tracks - Cytoplasmic roles for a nuclear regulator
    • Yudin, D. & Fainzilber, M. Ran on tracks - cytoplasmic roles for a nuclear regulator. J. Cell Sci. 122, 587-593 (2009).
    • (2009) J. Cell Sci , vol.122 , pp. 587-593
    • Yudin, D.1    Fainzilber, M.2
  • 86
    • 84876357595 scopus 로고    scopus 로고
    • Cell cycle-dependent binding modes of the ran exchange factor RCC1 to chromatin
    • Bierbaum, M. & Bastiaens, P. I. Cell cycle-dependent binding modes of the ran exchange factor RCC1 to chromatin. Biophys. J. 104, 1642-1651 (2013).
    • (2013) Biophys. J. , vol.104 , pp. 1642-1651
    • Bierbaum, M.1    Bastiaens, P.I.2
  • 87
    • 46649086170 scopus 로고    scopus 로고
    • RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules
    • Schulze, H. et al. RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. J. Biol. Chem. 283, 14109-14119 (2008).
    • (2008) J. Biol. Chem , vol.283 , pp. 14109-14119
    • Schulze, H.1
  • 88
    • 79960898593 scopus 로고    scopus 로고
    • Making and breaking synapses through local mRNA regulation
    • Swanger, S. A. & Bassell, G. J. Making and breaking synapses through local mRNA regulation. Curr. Opin. Genet. Dev. 21, 414-421 (2011).
    • (2011) Curr. Opin. Genet. Dev , vol.21 , pp. 414-421
    • Swanger, S.A.1    Bassell, G.J.2
  • 89
    • 65149104812 scopus 로고    scopus 로고
    • Ribosomes in axons - Scrounging from the neighbors?
    • Twiss, J. L. & Fainzilber, M. Ribosomes in axons - scrounging from the neighbors? Trends Cell Biol. 19, 236-243 (2009).
    • (2009) Trends Cell Biol , vol.19 , pp. 236-243
    • Twiss, J.L.1    Fainzilber, M.2
  • 90
    • 84864296464 scopus 로고    scopus 로고
    • Subcellular knockout of importin β1 perturbs axonal retrograde signaling
    • Perry, R. B. et al. Subcellular knockout of importin β1 perturbs axonal retrograde signaling. Neuron 75, 294-305 (2012). This study shows that knockout of an axon-localizing segment in the 3' UTR depletes importin β1 from sensory axons, thus demonstrating that local translation is required for retrograde injury signalling.
    • (2012) Neuron , vol.75 , pp. 294-305
    • Perry, R.B.1
  • 91
    • 77950859086 scopus 로고    scopus 로고
    • A human neuron injury model for molecular studies of axonal regeneration
    • Ziegler, L. et al. A human neuron injury model for molecular studies of axonal regeneration. Exp. Neurol. 223, 119-127 (2010).
    • (2010) Exp. Neurol , vol.223 , pp. 119-127
    • Ziegler, L.1
  • 92
    • 79951956331 scopus 로고    scopus 로고
    • Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on importin β
    • Ohara, R. et al. Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on importin β. Biochem. Biophys. Res. Commun. 405, 697-702 (2011).
    • (2011) Biochem. Biophys. Res. Commun , vol.405 , pp. 697-702
    • Ohara, R.1
  • 93
    • 79960912049 scopus 로고    scopus 로고
    • Nuclear import by karyopherin-βs: Recognition and inhibition
    • Chook, Y. M. & Suel, K. E. Nuclear import by karyopherin-βs: recognition and inhibition. Biochim. Biophys. Acta 1813, 1593-1606 (2011).
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 1593-1606
    • Chook, Y.M.1    Suel, K.E.2
  • 94
    • 30944452120 scopus 로고    scopus 로고
    • Impaired expression of importin/karyopherin β1 leads to post-implantation lethality
    • Miura, K. et al. Impaired expression of importin/karyopherin β1 leads to post-implantation lethality. Biochem. Biophys. Res. Commun. 341, 132-138 (2006).
    • (2006) Biochem. Biophys. Res. Commun , vol.341 , pp. 132-138
    • Miura, K.1
  • 95
    • 69549135202 scopus 로고    scopus 로고
    • To localize or not to localize: MRNA fate is in 3'UTR ends
    • Andreassi, C. & Riccio, A. To localize or not to localize: mRNA fate is in 3'UTR ends. Trends Cell Biol. 19, 465-474 (2009).
    • (2009) Trends Cell Biol , vol.19 , pp. 465-474
    • Andreassi, C.1    Riccio, A.2
  • 96
    • 36549026360 scopus 로고    scopus 로고
    • Tiling of r7 axons in the Drosophila visual system is mediated both by transduction of an activin signal to the nucleus and by mutual repulsion
    • Ting, C. Y. et al. Tiling of r7 axons in the Drosophila visual system is mediated both by transduction of an activin signal to the nucleus and by mutual repulsion. Neuron 56, 793-806 (2007).
    • (2007) Neuron , vol.56 , pp. 793-806
    • Ting, C.Y.1
  • 97
    • 69949112651 scopus 로고    scopus 로고
    • Dendritic mRNA targeting of Jacob and N-methyl-D-aspartate-induced nuclear translocation after calpain-mediated proteolysis
    • Kindler, S. et al. Dendritic mRNA targeting of Jacob and N-methyl-D-aspartate-induced nuclear translocation after calpain-mediated proteolysis. J. Biol. Chem. 284, 25431-25440 (2009).
    • (2009) J. Biol. Chem , vol.284 , pp. 25431-25440
    • Kindler, S.1
  • 98
    • 77950987081 scopus 로고    scopus 로고
    • Importin-β11 regulates synaptic phosphorylated mothers against decapentaplegic, and thereby influences synaptic development and function at the Drosophila neuromuscular junction
    • Higashi-Kovtun, M. E., Mosca, T. J., Dickman, D. K., Meinertzhagen, I. A. & Schwarz, T. L. Importin-β11 regulates synaptic phosphorylated mothers against decapentaplegic, and thereby influences synaptic development and function at the Drosophila neuromuscular junction. J. Neurosci. 30, 5253-5268 (2010).
    • (2010) J. Neurosci , vol.30 , pp. 5253-5268
    • Higashi-Kovtun, M.E.1    Mosca, T.J.2    Dickman, D.K.3    Meinertzhagen, I.A.4    Schwarz, T.L.5
  • 99
    • 84857275266 scopus 로고    scopus 로고
    • Local translation of extranuclear lamin B promotes axon maintenance
    • Yoon, B. C. et al. Local translation of extranuclear lamin B promotes axon maintenance. Cell 148, 752-764 (2012).
    • (2012) Cell , vol.148 , pp. 752-764
    • Yoon, B.C.1
  • 100
    • 0042819829 scopus 로고    scopus 로고
    • Corticospinal neurons up-regulate a range of growth-associated genes following intracortical, but not spinal, axotomy
    • Mason, M. R., Lieberman, A. R. & Anderson, P. N. Corticospinal neurons up-regulate a range of growth-associated genes following intracortical, but not spinal, axotomy. Eur. J. Neurosci. 18, 789-802 (2003).
    • (2003) Eur. J. Neurosci , vol.18 , pp. 789-802
    • Mason, M.R.1    Lieberman, A.R.2    Anderson, P.N.3
  • 101
    • 0032519651 scopus 로고    scopus 로고
    • Peripheral axotomy induces long-term c-Jun amino-terminal kinase-1 activation and activator protein-1 binding activity by c-Jun and junD in adult rat dorsal root ganglia in vivo
    • Kenney, A. M. & Kocsis, J. D. Peripheral axotomy induces long-term c-Jun amino-terminal kinase-1 activation and activator protein-1 binding activity by c-Jun and junD in adult rat dorsal root ganglia in vivo. J. Neurosci. 18, 1318-1328 (1998).
    • (1998) J. Neurosci , vol.18 , pp. 1318-1328
    • Kenney, A.M.1    Kocsis, J.D.2
  • 102
    • 0033956898 scopus 로고    scopus 로고
    • Activating transcription factor 3 (ATF3) induction by axotomy in sensory and motoneurons: A novel neuronal marker of nerve injury
    • Tsujino, H. et al. Activating transcription factor 3 (ATF3) induction by axotomy in sensory and motoneurons: a novel neuronal marker of nerve injury. Mol. Cell Neurosci. 15, 170-182 (2000).
    • (2000) Mol. Cell Neurosci , vol.15 , pp. 170-182
    • Tsujino, H.1
  • 103
    • 0023610736 scopus 로고
    • Survival and subsequent regeneration of olfactory neurons after a distal axonal lesion
    • Cancalon, P. F. Survival and subsequent regeneration of olfactory neurons after a distal axonal lesion. J. Neurocytol. 16, 829-841 (1987).
    • (1987) J. Neurocytol , vol.16 , pp. 829-841
    • Cancalon P., .F.1
  • 104
    • 0033831714 scopus 로고    scopus 로고
    • Axonal regeneration of retinal ganglion cells depending on the distance of axotomy in adult hamsters
    • You, S.-W., So, K.-F. & Yip, H. K. Axonal regeneration of retinal ganglion cells depending on the distance of axotomy in adult hamsters. Invest. Ophthalmol. Vis. Sci. 41, 3165-3170 (2000).
    • (2000) Invest. Ophthalmol. Vis. Sci , vol.41 , pp. 3165-3170
    • You, S.-W.1    So, K.-F.2    Yip, H.K.3
  • 105
    • 70049086023 scopus 로고    scopus 로고
    • Can molecular motors drive distance measurements in injured neurons?
    • Kam, N., Pilpel, Y. & Fainzilber, M. Can molecular motors drive distance measurements in injured neurons? PLoS Comput. Biol. 5, e1000477 (2009).
    • (2009) PLoS Comput. Biol , vol.5
    • Kam, N.1    Pilpel, Y.2    Fainzilber, M.3
  • 106
    • 84863090639 scopus 로고    scopus 로고
    • A motor driven mechanism for cell length sensing
    • Rishal, I. et al. A motor driven mechanism for cell length sensing. Cell Rep. 1, 608-616 (2012). This study proposes a frequency-dependent mechanism for encoding intracellular length or distance.
    • (2012) Cell Rep , vol.1 , pp. 608-616
    • Rishal, I.1
  • 107
    • 84881625648 scopus 로고    scopus 로고
    • An analytical solution describing the propagation of positive injury signals in an axon: Effect of dynein velocity distribution
    • Kuznetsov, A. V. An analytical solution describing the propagation of positive injury signals in an axon: effect of dynein velocity distribution. Comput. Methods Biomech. Biomed. Engin. 16, 699-706 (2013).
    • (2013) Comput. Methods Biomech. Biomed. Engin , vol.16 , pp. 699-706
    • Kuznetsov, A.V.1
  • 108
    • 84879602343 scopus 로고    scopus 로고
    • Cell length sensing for neuronal growth control
    • Albus, C. A., Rishal, I. & Fainzilber, M. Cell length sensing for neuronal growth control. Trends Cell Biol. 23, 305-310 (2013).
    • (2013) Trends Cell Biol , vol.23 , pp. 305-310
    • Albus, C.A.1    Rishal, I.2    Fainzilber, M.3
  • 109
    • 33644524741 scopus 로고    scopus 로고
    • Cell-signalling dynamics in time and space
    • Kholodenko, B. N. Cell-signalling dynamics in time and space. Nature Rev. Mol. Cell Biol. 7, 165-176 (2006).
    • (2006) Nature Rev. Mol. Cell Biol , vol.7 , pp. 165-176
    • Kholodenko, B.N.1
  • 110
    • 78349310786 scopus 로고    scopus 로고
    • Oscillatory signaling processes: The how, the why and the where
    • Cheong, R. & Levchenko, A. Oscillatory signaling processes: the how, the why and the where. Curr. Opin. Genet. Dev. 20, 665-669 (2010).
    • (2010) Curr. Opin. Genet. Dev , vol.20 , pp. 665-669
    • Cheong, R.1    Levchenko, A.2
  • 112
    • 84858115857 scopus 로고    scopus 로고
    • Reliability of frequency and amplitude decoding in gene regulation
    • Tostevin, F., de Ronde, W. & ten Wolde, P. R. Reliability of frequency and amplitude decoding in gene regulation. Phys. Rev. Lett. 108, 108104 (2012).
    • (2012) Phys. Rev. Lett , vol.108 , pp. 108104
    • Tostevin, F.1    De Ronde, W.2    Ten Wolde, P.R.3
  • 113
    • 84872796463 scopus 로고    scopus 로고
    • Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals
    • Albeck, J. G., Mills, G. B. & Brugge, J. S. Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. Mol. Cell 49, 249-261 (2013).
    • (2013) Mol. Cell , vol.49 , pp. 249-261
    • Albeck, J.G.1    Mills, G.B.2    Brugge, J.S.3
  • 114
    • 52949098296 scopus 로고    scopus 로고
    • Frequency-modulated nuclear localization bursts coordinate gene regulation
    • Cai, L., Dalal, C. K. & Elowitz, M. B. Frequency-modulated nuclear localization bursts coordinate gene regulation. Nature 455, 485-490 (2008).
    • (2008) Nature , vol.455 , pp. 485-490
    • Cai, L.1    Dalal, C.K.2    Elowitz, M.B.3
  • 115
    • 84861913362 scopus 로고    scopus 로고
    • Transcription factor oscillations induce differential gene expressions
    • Wee, K. B., Yio, W. K., Surana, U. & Chiam, K. H. Transcription factor oscillations induce differential gene expressions. Biophys. J. 102, 2413-2423 (2012).
    • (2012) Biophys. J. , vol.102 , pp. 2413-2423
    • Wee, K.B.1    Yio, W.K.2    Surana, U.3    Chiam, K.H.4
  • 116
    • 34547412828 scopus 로고    scopus 로고
    • Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum
    • Yoshiura, S. et al. Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum. Proc. Natl Acad. Sci. USA 104, 11292-11297 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 11292-11297
    • Yoshiura, S.1
  • 117
    • 66749182241 scopus 로고    scopus 로고
    • Axotomy-induced Smad1 activation promotes axonal growth in adult sensory neurons
    • Zou, H., Ho, C., Wong, K. & Tessier-Lavigne, M. Axotomy-induced Smad1 activation promotes axonal growth in adult sensory neurons. J. Neurosci. 29, 7116-7123 (2009).
    • (2009) J. Neurosci , vol.29 , pp. 7116-7123
    • Zou, H.1    Ho, C.2    Wong, K.3    Tessier-Lavigne, M.4
  • 118
    • 0037175326 scopus 로고    scopus 로고
    • Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury
    • Costigan, M. et al. Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci. 3, 16 (2002).
    • (2002) BMC Neurosci , vol.3 , pp. 16
    • Costigan, M.1
  • 119
    • 14944359702 scopus 로고    scopus 로고
    • Proteomics of the injured rat sciatic nerve reveals protein expression dynamics during regeneration
    • Jimenez, C. R. et al. Proteomics of the injured rat sciatic nerve reveals protein expression dynamics during regeneration. Mol. Cell Proteom. 4, 120-132 (2005).
    • (2005) Mol. Cell Proteom , vol.4 , pp. 120-132
    • Jimenez, C.R.1
  • 120
    • 19944432196 scopus 로고    scopus 로고
    • Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons
    • Willis, D. et al. Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons. J. Neurosci. 25, 778-791 (2005).
    • (2005) J. Neurosci , vol.25 , pp. 778-791
    • Willis, D.1
  • 121
    • 0033137077 scopus 로고    scopus 로고
    • Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury
    • Neumann, S. & Woolf, C. J. Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury. Neuron 23, 83-91 (1999).
    • (1999) Neuron , vol.23 , pp. 83-91
    • Neumann, S.1    Woolf, C.J.2
  • 122
    • 78449235139 scopus 로고    scopus 로고
    • Long-distance axon regeneration in the mature optic nerve: Contributions of oncomodulin, cAMP, and pten gene deletion
    • Kurimoto, T. et al. Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion. J. Neurosci. 30, 15654-15663 (2010).
    • (2010) J. Neurosci , vol.30 , pp. 15654-15663
    • Kurimoto, T.1
  • 123
    • 66249141133 scopus 로고    scopus 로고
    • Chronically CNS-injured adult sensory neurons gain regenerative competence upon a lesion of their peripheral axon
    • Ylera, B. et al. Chronically CNS-injured adult sensory neurons gain regenerative competence upon a lesion of their peripheral axon. Curr. Biol. 19, 930-936 (2009).
    • (2009) Curr. Biol , vol.19 , pp. 930-936
    • Ylera, B.1
  • 124
    • 70350203996 scopus 로고    scopus 로고
    • Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury
    • Kadoya, K. et al. Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury. Neuron 64, 165-172 (2009).
    • (2009) Neuron , vol.64 , pp. 165-172
    • Kadoya, K.1
  • 125
    • 80052636605 scopus 로고    scopus 로고
    • DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity
    • Ghosh, A. S. et al. DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity. J. Cell Biol. 194, 751-764 (2011).
    • (2011) J. Cell Biol , vol.194 , pp. 751-764
    • Ghosh, A.S.1
  • 126
    • 84867725772 scopus 로고    scopus 로고
    • Kinesin-13 and tubulin posttranslational modifications regulate microtubule growth in axon regeneration
    • Ghosh-Roy, A., Goncharov, A., Jin, Y. & Chisholm, A. D. Kinesin-13 and tubulin posttranslational modifications regulate microtubule growth in axon regeneration. Dev. Cell 23, 716-728 (2012).
    • (2012) Dev. Cell , vol.23 , pp. 716-728
    • Ghosh-Roy, A.1    Goncharov, A.2    Jin, Y.3    Chisholm, A.D.4
  • 127
    • 84871676498 scopus 로고    scopus 로고
    • Growth cone MKK7 mRNA targeting regulates MAP1b-dependent microtubule bundling to control neurite elongation
    • Feltrin, D. et al. Growth cone MKK7 mRNA targeting regulates MAP1b-dependent microtubule bundling to control neurite elongation. PLoS Biol. 10, e1001439 (2012).
    • (2012) PLoS Biol , vol.10
    • Feltrin, D.1
  • 128
    • 0037148523 scopus 로고    scopus 로고
    • Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult
    • Schweizer, U. et al. Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult. J. Cell Biol. 156, 287-297 (2002).
    • (2002) J. Cell Biol , vol.156 , pp. 287-297
    • Schweizer, U.1
  • 129
    • 44649113676 scopus 로고    scopus 로고
    • STAT3 activation protects retinal ganglion cell layer neurons in response to stress
    • Zhang, C. et al. STAT3 activation protects retinal ganglion cell layer neurons in response to stress. Exp. Eye Res. 86, 991-997 (2008).
    • (2008) Exp. Eye Res , vol.86 , pp. 991-997
    • Zhang, C.1
  • 130
    • 33748681723 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-3 suppresses the ability of activated signal transducer and activator of transcription-3 to stimulate neurite growth in rat primary sensory neurons
    • Miao, T. et al. Suppressor of cytokine signaling-3 suppresses the ability of activated signal transducer and activator of transcription-3 to stimulate neurite growth in rat primary sensory neurons. J. Neurosci. 26, 9512-9519 (2006).
    • (2006) J. Neurosci , vol.26 , pp. 9512-9519
    • Miao, T.1
  • 131
    • 79955038586 scopus 로고    scopus 로고
    • In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration
    • Bareyre, F. M. et al. In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration. Proc. Natl Acad. Sci. USA 108, 6282-6287 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 6282-6287
    • Bareyre, F.M.1
  • 132
    • 83555174832 scopus 로고    scopus 로고
    • Sustained axon regeneration induced by co-deletion of PTEN and SOCS3
    • Sun, F. et al. Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature 480, 372-375 (2011).
    • (2011) Nature , vol.480 , pp. 372-375
    • Sun, F.1
  • 133
    • 80755155808 scopus 로고    scopus 로고
    • Multiple transcription factor families regulate axon growth and regeneration
    • Moore, D. L. & Goldberg, J. L. Multiple transcription factor families regulate axon growth and regeneration. Dev. Neurobiol. 71, 1186-1211 (2011).
    • (2011) Dev. Neurobiol , vol.71 , pp. 1186-1211
    • Moore, D.L.1    Goldberg, J.L.2
  • 134
    • 84875227144 scopus 로고    scopus 로고
    • Waking up the sleepers: Shared transcriptional pathways in axonal regeneration and neurogenesis
    • Quadrato, G. & Di Giovanni, S. Waking up the sleepers: shared transcriptional pathways in axonal regeneration and neurogenesis. Cell. Mol. Life Sci. 70, 993-1007 (2013).
    • (2013) Cell. Mol. Life Sci , vol.70 , pp. 993-1007
    • Quadrato, G.1    Di Giovanni, S.2
  • 135
    • 84886285005 scopus 로고    scopus 로고
    • Epigenetic regulation of axon outgrowth and regeneration in CNS injury: The first steps forward
    • Lindner, R., Puttagunta, R. & Di Giovanni, S. Epigenetic regulation of axon outgrowth and regeneration in CNS injury: the first steps forward. Neurotherapeutics 10, 771-781 (2013).
    • (2013) Neurotherapeutics , vol.10 , pp. 771-781
    • Lindner, R.1    Puttagunta, R.2    Di Giovanni, S.3
  • 136
    • 84873323723 scopus 로고    scopus 로고
    • Vesicular glycolysis provides on-board energy for fast axonal transport
    • Zala, D. et al. Vesicular glycolysis provides on-board energy for fast axonal transport. Cell 152, 479-491 (2013). This intriguing study provides new insights on how energy might be provided for motor-dependent transport along axons.
    • (2013) Cell , vol.152 , pp. 479-491
    • Zala, D.1
  • 138
    • 84893780287 scopus 로고    scopus 로고
    • Molecular determinants of the axonal mRNA transcriptome
    • Gomes, C., Merianda, T. T., Lee, S. J., Yoo, S. & Twiss, J. L. Molecular determinants of the axonal mRNA transcriptome. Dev. Neurobiol. http://dx.doi.org/10.1002/dneu.22123 (2013).
    • (2013) Dev. Neurobiol
    • Gomes, C.1    Merianda, T.T.2    Lee, S.J.3    Yoo, S.4    Twiss, J.L.5
  • 140
    • 84867756855 scopus 로고    scopus 로고
    • Drug delivery systems with modified release for systemic and biophase bioavailability
    • Leucuta, S. E. Drug delivery systems with modified release for systemic and biophase bioavailability. Curr. Clin. Pharmacol. 7, 282-317 (2012).
    • (2012) Curr. Clin. Pharmacol , vol.7 , pp. 282-317
    • Leucuta, S.E.1
  • 141
    • 84868204663 scopus 로고    scopus 로고
    • Reservoir-based drug delivery systems utilizing microtechnology
    • Stevenson, C. L., Santini, J. T. Jr & Langer, R. Reservoir-based drug delivery systems utilizing microtechnology. Adv. Drug Deliv. Rev. 64, 1590-1602 (2012).
    • (2012) Adv. Drug Deliv. Rev , vol.64 , pp. 1590-1602
    • Stevenson, C.L.1    Santini Jr., J.T.2    Langer, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.