Long-distance axonal transport of AAV9 is driven by dynein and kinesin-2 and is trafficked in a highly motile Rab7-positive compartment

Molecular Therapy

Volumn 22, Issue 3, 2014, Pages 554-566

  Castle, Michael J ^a,b,c   Perlson, Eran ^c,d   Holzbaur, Erika L F ^c   Wolfe, John H ^a,b,c  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ADENO ASSOCIATED VIRUS 9 VECTOR; DYNEIN ADENOSINE TRIPHOSPHATASE; KINESIN 2; PARVOVIRUS VECTOR; RAB7 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CELL POPULATION; CELLULAR DISTRIBUTION; EGFP TRANSGENE; ENDOSOME; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSDUCTION; LYSOSOME; MICROFLUIDIC ANALYSIS; NERVE FIBER TRANSPORT; NONHUMAN; PERIKARYON; RAT; TRANSGENE; VELOCITY; VIRAL GENE DELIVERY SYSTEM;

ADENO-ASSOCIATED VIRUS;

ANIMALS; AXONAL TRANSPORT; CELLS, CULTURED; DEPENDOVIRUS; DYNEINS; ENDOSOMES; KINESIN; NEURAMINIDASE; NEURONS; RAB GTP-BINDING PROTEINS; RATS;

EID: 84895461561     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2013.237     Document Type: Article

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