Two binding partners cooperate to activate the molecular motor Kinesin-1

Journal of Cell Biology

Volumn 176, Issue 1, 2007, Pages 11-17

  Blasius, T Lynne ^a   Cai, Dawen ^a   Jih, Gloria T ^a   Toret, Christopher P ^b   Verhey, Kristen J ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; C JUN N TERMINAL KINASE INTERACTING PROTEIN 1; CARRIER PROTEIN; FASCICULATION AND ELONGATION PROTEIN ZETA1; KINESIN; KINESIN 1; MOLECULAR MOTOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HEAVY CHAIN; IN VITRO STUDY; MICROTUBULE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; COS CELLS; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GENES, DOMINANT; HUMANS; KINESIN; MICROTUBULE-ASSOCIATED PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN TRANSPORT; RATS; TUMOR SUPPRESSOR PROTEINS;

EID: 33845967100     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200605099     Document Type: Article

References (31)

1. Adio, S., J. Reth, F. Bathe, and G. Woehlke. 2006. Review: regulation mechanisms of Kinesin-1. J. Muscle Res. Cell Motil. 27:153-160.
2. Bathe, F., K. Hahlen, R. Dombi, L. Driller, M. Schliwa, and G. Woehlke. 2005. The complex interplay between the neck and hinge domains in kinesin-1 dimerization and motor activity. Mol. Biol. Cell. 16:3529-3537.
3. Bloom, L., and H.R. Horvitz. 1997. The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. Proc. Natl. Acad. Sci. USA. 94:3414-3419.
4. Cai, D., A.D. Hoppe, J.A. Swanson, and K.J. Verhey. 2007. Kinesin-1 structural organization and conformational changes revealed by FRET stoichiometry in live cells. J. Cell Biol. 176:51-63.
5. Coy, D.L., W.O. Hancock, M. Wagenbach, and J. Howard. 1999. Kinesin's tail domain is an inhibitory regulator of the motor domain. Nat. Cell Biol. 1:288-292.
6. Cross, R., and J. Scholey. 1999. Kinesin: the tail unfolds. Nat. Cell Biol. 1:E119-E121.
7. Gindhart, J.G., J. Chen, M. Faulkner, R. Gandhi, K. Doerner, T. Wisniewski, and A. Nandlestadt. 2003. The kinesin-associated protein UNC-76 is required for axonal transport in the Drosophila nervous system. Mol. Biol. Cell. 14:3356-3365.
8. Griesbeck, O., G.S. Baird, R.E. Campbell, D.A. Zacharias, and R.Y. Tsien. 2001. Reducing the environmental sensitivity of yellow fluorescent protein. J. Biol. Chem. 276:29188-29194.
9. Guzik, B.W., and L.S. Goldstein. 2004. Microtubule-dependent transport in neurons: steps towards an understanding of regulation, function and dysfunction. Curr. Opin. Cell Biol. 16: 443-450.
10. Hackney, D.D., and M.F. Stock. 2000. Kinesin's IAK tail domain inhibits initial microtubule-stimulated ADP release. Nat. Cell Biol. 2:257-260.
11. Hirokawa, N., and R. Takemura. 2005. Molecular motors and mechanisms of directional transport in neurons. Nat. Rev. Neurosci. 6:201-214.
12. Jiang, M.Y., and M.P. Sheetz. 1995. Cargo-activated ATPase activity of kinesin. Biophys. J. 68:283S-284S.
13. Klopfenstein, D.R., M. Tomishige, N. Stuurman, and R.D. Vale. 2002. Role of phosphatidylinositol(4,5)bisphosphate organization in membrane transport by the Unc104 kinesin motor. Cell. 109:347-358.
14. Kuroda, S., N. Nakagawa, C. Tokunaga, K. Tatematsu, and K. Tanizawa. 1999. Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C ζ-interacting protein. J. Cell Biol. 144:403-411.
15. Lee, J.R., H. Shin, J. Choi, J. Ko, S. Kim, H.W. Lee, K. Kim, S.H. Rho, J.H. Lee, H.E. Song, et al. 2004. An intramolecular interaction between the FHA domain and a coiled coil negatively regulates the kinesin motor KIF1A. EMBO J. 23:1506-1515.
16. Lee, S., C.L. Walker, B. Karten, S.L. Kuny, A.A. Tennese, M.A. O'Neill, and R. Wevrick. 2005. Essential role for the Prader-Willi syndrome protein necdin in axonal outgrowth. Hum. Mol. Genet. 14:627-637.
17. Li, X.D., R. Ikebe, and M. Ikebe. 2005. Activation of myosin Va function by melanophilin, a specific docking partner of myosin Va. J. Biol. Chem. 280:17815-17822.
18. Mallik, R., and S.P. Gross. 2004. Molecular motors: strategies to get along. Curr. Biol. 14:R971-R982.
19. Miyoshi, K., A. Honda, K. Baba, M. Taniguchi, K. Oono, T. Fujita, S. Kuroda, T. Katayama, and M. Tohyama. 2003. Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Mol. Psychiatry. 8:685-694.
20. Notredame, C., D.G. Higgins, and J. Heringa. 2000. T-Coffee: a novel method for fast and accurate multiple sequence alignment. J. Mol. Biol. 302:205-217.
21. Ohlmann, T., and R.J. Jackson. 1999. The properties of chimeric picornavirus IRESes show that discrimination between internal translation initiation sites is influenced by the identity of the IRES and not just the context of the AUG codon. RNA. 5:764-778.
22. Okumura, F., S. Hatakeyama, M. Matsumoto, T. Kamura, and K.I. Nakayama. 2004. Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. J. Biol. Chem. 279:53533-53543.
23. Schliwa, M., and G. Woehlke. 2003. Molecular motors. Nature. 422:759-765.
24. Schroer, T.A. 2004. Dynactin. Annu. Rev. Cell Dev. Biol. 20:759-779.
25. Seiler, S., J. Kirchner, C. Horn, A. Kallipolitou, G. Woehlke, and M. Schliwa. 2000. Cargo binding and regulatory sites in the tail of fungal conventional kinesin. Nat. Cell Biol. 2:333-338.
26. Stock, M.F., J. Guerrero, B. Cobb, C.T. Eggers, T.G. Huang, X. Li, and D.D. Hackney. 1999. Formation of the compact conformer of kinesin requires a C-terminal heavy chain domain and inhibits microtubule-stimulated ATPase activity. J. Biol. Chem. 274:14617-14623.
27. Suzuki, T., Y. Okada, S. Semba, Y. Orba, S. Yamanouchi, S. Endo, S. Tanaka, T. Fujita, S. Kuroda, K. Nagashima, and H. Sawa. 2005. Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules. J. Biol. Chem. 280:24948-24956.
28. Verhey, K.J., and T.A. Rapoport. 2001. Kinesin carries the signal. Trends Biochem. Sci. 26:545-550.
29. Verhey, K.J., D.L. Lizotte, T. Abramson, L. Barenboim, B.J. Schnapp, and T.A. Rapoport. 1998. Light chain-dependent regulation of Kinesin's interaction with microtubules. J. Cell Biol. 143:1053-1066.
30. Verhey, K.J., D. Meyer, R. Deehan, J. Blenis, B.J. Schnapp, T.A. Rapoport, and B. Margolis. 2001. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. J. Cell Biol. 152:959-970.
31. Yonekura, H., A. Nomura, H. Ozawa, Y. Tatsu, N. Yumoto, and T.Q. Uyeda. 2006. Mechanism of tail-mediated inhibition of kinesin activities studied using synthetic peptides. Biochem. Biophys. Res. Commun. 343:420-427.