Molecular chaperone Hsp110 rescues a vesicle transport defect produced by an ALS-associated mutant SOD1 protein in squid axoplasm

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 14, 2013, Pages 5428-5433

  Song, Yuyu ^a,b   Nagy, Maria ^c,d   Ni, Weiming ^c,d   Tyagi, Navneet K ^c,d   Fenton, Wayne A ^c   López Giráldez, Francesc ^c   Overton, John D ^c   Horwich, Arthur L ^c,d   Brady, Scott T ^b,e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MARINE BIOLOGICAL LABORATORY   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Axoplasmic transport; SOD1 linked ALS

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1 INHIBITOR; COPPER ZINC SUPEROXIDE DISMUTASE; HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN 110; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; AXOPLASM; CYTOPLASM VESICLE; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN BINDING; SPINAL CORD; SQUID; STOICHIOMETRY; TRANSGENIC MOUSE;

ANIMALS; AXONAL TRANSPORT; BACTERIAL PROTEINS; DECAPODIFORMES; GENE EXPRESSION PROFILING; HSP110 HEAT-SHOCK PROTEINS; HUMANS; LUMINESCENT PROTEINS; MAP KINASE KINASE KINASE 5; MICE; MICE, TRANSGENIC; MUTATION, MISSENSE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN FOLDING; PROTEOMICS; RECOMBINANT FUSION PROTEINS; SPINAL CORD; SUPEROXIDE DISMUTASE; TRANSPORT VESICLES;

CEPHALOPODA; MAMMALIA; MUS MUSCULUS;

EID: 84875845592     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1303279110     Document Type: Article

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