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Volumn 190, Issue , 2014, Pages 82-93

Organ-on-a-chip platforms for studying drug delivery systems

Author keywords

Drug delivery; Drug screening; Nanoparticle; Organ on a chip; Toxicity

Indexed keywords

CLINICAL RESEARCH; DRUG DELIVERY; MICROFLUIDICS; NANOPARTICLES; TARGETED DRUG DELIVERY; TOXICITY; COMPLEX NETWORKS;

EID: 84906781892     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.05.004     Document Type: Review
Times cited : (315)

References (126)
  • 1
    • 33751419875 scopus 로고    scopus 로고
    • Nanomedicine: Developing smarter therapeutic and diagnostic modalities
    • DOI 10.1016/j.addr.2006.09.011, PII S0169409X06001736, Particulate Nanomedicines
    • O.C. Farokhzad, and R. Langer Nanomedicine: developing smarter therapeutic and diagnostic modalities Adv. Drug Deliv. Rev. 58 2006 1456 1459 (Pubitemid 44820502)
    • (2006) Advanced Drug Delivery Reviews , vol.58 , Issue.14 , pp. 1456-1459
    • Farokhzad, O.C.1    Langer, R.2
  • 2
    • 4444282326 scopus 로고    scopus 로고
    • Intelligent therapeutics: Biomimetic systems and nanotechnology in drug delivery
    • DOI 10.1016/j.addr.2004.07.001, PII S0169409X04001486
    • N.A. Peppas Intelligent therapeutics: biomimetic systems and nanotechnology in drug delivery Adv. Drug Deliv. Rev. 56 2004 1529 1531 (Pubitemid 39177686)
    • (2004) Advanced Drug Delivery Reviews , vol.56 , Issue.11 , pp. 1529-1531
    • Peppas, N.A.1
  • 3
    • 0015899008 scopus 로고
    • Drug entrapment in liposomes
    • G. Gregoriadis Drug entrapment in liposomes FEBS Lett. 36 1973 292 296
    • (1973) FEBS Lett. , vol.36 , pp. 292-296
    • Gregoriadis, G.1
  • 4
    • 0015866042 scopus 로고
    • Enzyme-containing liposomes alleviate a model for storage disease
    • G. Gregoriadis, and R.A. Buckland Enzyme-containing liposomes alleviate a model for storage disease Nature 244 1973 170 172
    • (1973) Nature , vol.244 , pp. 170-172
    • Gregoriadis, G.1    Buckland, R.A.2
  • 5
    • 84887303593 scopus 로고    scopus 로고
    • Mind the gap: A survey of how cancer drug carriers are susceptible to the gap between research and practice
    • D.L. Stirland, J.W. Nichols, S. Miura, and Y.H. Bae Mind the gap: a survey of how cancer drug carriers are susceptible to the gap between research and practice J. Control. Release 172 2013 1045 1064
    • (2013) J. Control. Release , vol.172 , pp. 1045-1064
    • Stirland, D.L.1    Nichols, J.W.2    Miura, S.3    Bae, Y.H.4
  • 6
    • 70350776969 scopus 로고    scopus 로고
    • Nanoparticle albumin-bound (NAB) technology is a promising method for anti-cancer drug delivery
    • Q. Fu, J. Sun, W. Zhang, X. Sui, Z. Yan, and Z. He Nanoparticle albumin-bound (NAB) technology is a promising method for anti-cancer drug delivery Recent Pat. Anticancer Drug Discov. 4 2009 262 272
    • (2009) Recent Pat. Anticancer Drug Discov. , vol.4 , pp. 262-272
    • Fu, Q.1    Sun, J.2    Zhang, W.3    Sui, X.4    Yan, Z.5    He, Z.6
  • 7
    • 84897671431 scopus 로고    scopus 로고
    • One-step two-dimensional microfluidics-based synthesis of three-dimensional particles
    • N. Hakimi, S.S. Tsai, C.H. Cheng, and D.K. Hwang One-step two-dimensional microfluidics-based synthesis of three-dimensional particles Adv. Mater. 26 2013 1393 1398
    • (2013) Adv. Mater. , vol.26 , pp. 1393-1398
    • Hakimi, N.1    Tsai, S.S.2    Cheng, C.H.3    Hwang, D.K.4
  • 8
    • 84891362991 scopus 로고    scopus 로고
    • Microfluidic platform for combinatorial synthesis and optimization of targeted nanoparticles for cancer therapy
    • P.M. Valencia, E.M. Pridgen, M. Rhee, R. Langer, O.C. Farokhzad, and R. Karnik Microfluidic platform for combinatorial synthesis and optimization of targeted nanoparticles for cancer therapy ACS Nano 7 2013 10671 10680
    • (2013) ACS Nano , vol.7 , pp. 10671-10680
    • Valencia, P.M.1    Pridgen, E.M.2    Rhee, M.3    Langer, R.4    Farokhzad, O.C.5    Karnik, R.6
  • 12
    • 33747117373 scopus 로고    scopus 로고
    • The origins and the future of microfluidics
    • DOI 10.1038/nature05058, PII NATURE05058
    • G.M. Whitesides The origins and the future of microfluidics Nature 442 2006 368 373 (Pubitemid 44264779)
    • (2006) Nature , vol.442 , Issue.7101 , pp. 368-373
    • Whitesides, G.M.1
  • 16
    • 84871033897 scopus 로고    scopus 로고
    • Microfluidic technologies for accelerating the clinical translation of nanoparticles
    • P.M. Valencia, O.C. Farokhzad, R. Karnik, and R. Langer Microfluidic technologies for accelerating the clinical translation of nanoparticles Nat. Nanotechnol. 7 2012 623 629
    • (2012) Nat. Nanotechnol. , vol.7 , pp. 623-629
    • Valencia, P.M.1    Farokhzad, O.C.2    Karnik, R.3    Langer, R.4
  • 17
    • 77957862803 scopus 로고    scopus 로고
    • A new perspective on in vitro assessment method for evaluating quantum dot toxicity by using microfluidics technology
    • S.K. Mahto, T.H. Yoon, and S.W. Rhee A new perspective on in vitro assessment method for evaluating quantum dot toxicity by using microfluidics technology Biomicrofluidics 4 2010
    • (2010) Biomicrofluidics , vol.4
    • Mahto, S.K.1    Yoon, T.H.2    Rhee, S.W.3
  • 18
    • 40449122796 scopus 로고    scopus 로고
    • Nanoparticle-mediated cellular response is size-dependent
    • DOI 10.1038/nnano.2008.30, PII NNANO200830
    • W. Jiang, Y.S. KimBetty, J.T. Rutka, and W.C.W. Chan Nanoparticle- mediated cellular response is size-dependent Nat. Nanotechnol. 3 2008 145 150 (Pubitemid 351355131)
    • (2008) Nature Nanotechnology , vol.3 , Issue.3 , pp. 145-150
    • Jiang, W.1    Kim, B.Y.S.2    Rutka, J.T.3    Chan, W.C.W.4
  • 19
    • 33646397592 scopus 로고    scopus 로고
    • Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells
    • B.D. Chithrani, A.A. Ghazani, and W.C.W. Chan Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells Nano Lett. 6 2006 662 668
    • (2006) Nano Lett. , vol.6 , pp. 662-668
    • Chithrani, B.D.1    Ghazani, A.A.2    Chan, W.C.W.3
  • 20
    • 0032127350 scopus 로고    scopus 로고
    • Recombinant humanized anti-HER2 antibody (herceptin(TM)) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts
    • J. Baselga, L. Norton, J. Albanell, Y.-M. Kim, and J. Mendelsohn Recombinant humanized anti-HER2 antibody (Herceptin(TM)) enhances the antitumor activity of Paclitaxel and Doxorubicin against HER2/neu overexpressing human breast cancer xenografts Cancer Res. 58 1998 2825 2831 (Pubitemid 28311914)
    • (1998) Cancer Research , vol.58 , Issue.13 , pp. 2825-2831
    • Baselga, J.1    Norton, L.2    Albanell, J.3    Kim, Y.-M.4    Mendelsohn, J.5
  • 22
    • 79960132035 scopus 로고    scopus 로고
    • The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles
    • E.C. Cho, Q. Zhang, and Y. Xia The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles Nat. Nanotechnol. 6 2011 385 391
    • (2011) Nat. Nanotechnol. , vol.6 , pp. 385-391
    • Cho, E.C.1    Zhang, Q.2    Xia, Y.3
  • 23
    • 77956012564 scopus 로고    scopus 로고
    • The relationship between terminal functionalization and molecular weight of a gene delivery polymer and transfection efficacy in mammary epithelial 2-D cultures and 3-D organotypic cultures
    • N.S. Bhise, R.S. Gray, J.C. Sunshine, S. Htet, A.J. Ewald, and J.J. Green The relationship between terminal functionalization and molecular weight of a gene delivery polymer and transfection efficacy in mammary epithelial 2-D cultures and 3-D organotypic cultures Biomaterials 31 2010 8088 8096
    • (2010) Biomaterials , vol.31 , pp. 8088-8096
    • Bhise, N.S.1    Gray, R.S.2    Sunshine, J.C.3    Htet, S.4    Ewald, A.J.5    Green, J.J.6
  • 24
    • 0042904900 scopus 로고    scopus 로고
    • Comparison of primary human hepatocytes and hepatoma cell line HepG2 with regard to their biotransformation properties
    • DOI 10.1124/dmd.31.8.1035
    • S. Wilkening, F. Stahl, and A. Bader Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties Drug Metab. Dispos. 31 2003 1035 1042 (Pubitemid 36975674)
    • (2003) Drug Metabolism and Disposition , vol.31 , Issue.8 , pp. 1035-1042
    • Wilkening, S.1    Stahl, F.2    Bader, A.3
  • 25
    • 0032508679 scopus 로고    scopus 로고
    • Multicellular spheroids as an in vitro tumor model
    • DOI 10.1016/S0304-3835(98)00198-0, PII S0304383598001980
    • G. Hamilton Multicellular spheroids as an in vitro tumor model Cancer Lett. 131 1998 29 34 (Pubitemid 28467038)
    • (1998) Cancer Letters , vol.131 , Issue.1 , pp. 29-34
    • Hamilton, G.1
  • 28
    • 0033101647 scopus 로고    scopus 로고
    • Multicellular tumor spheroids: Intermediates between monolayer culture and in vivo tumor
    • DOI 10.1006/cbir.1999.0384
    • L.A. Kunz-Schughart Multicellular tumor spheroids: intermediates between monolayer culture and in vivo tumor Cell Biol. Int. 23 1999 157 161 (Pubitemid 29535146)
    • (1999) Cell Biology International , vol.23 , Issue.3 , pp. 157-161
    • Kunz-Schughart, L.A.1
  • 30
    • 0017726744 scopus 로고
    • A simplified method for production and growth of multicellular tumor spheroids
    • J.M. Yuhas, A.P. Li, A.O. Martinez, and A.J. Ladman A simplified method for production and growth of multicellular tumor spheroids Cancer Res. 37 1977 3639 3643 (Pubitemid 8198426)
    • (1977) Cancer Research , vol.37 , Issue.10 , pp. 3639-3643
    • Yuhas, J.M.1    Li, A.P.2    Martinez, A.O.3    Ladman, A.J.4
  • 31
    • 78751560396 scopus 로고    scopus 로고
    • High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array
    • Y.-C. Tung, A.Y. Hsiao, S.G. Allen, Y.-s. Torisawa, M. Ho, and S. Takayama High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array Analyst 136 2011 473 478
    • (2011) Analyst , vol.136 , pp. 473-478
    • Tung, Y.-C.1    Hsiao, A.Y.2    Allen, S.G.3    Ho, M.4    Takayama, S.5
  • 34
    • 84874417846 scopus 로고    scopus 로고
    • Systematic analysis of embryonic stem cell differentiation in hydrodynamic environments with controlled embryoid body size
    • M.A. Kinney, R. Saeed, and T.C. McDevitt Systematic analysis of embryonic stem cell differentiation in hydrodynamic environments with controlled embryoid body size Integr. Biol. 4 2012 641 650
    • (2012) Integr. Biol. , vol.4 , pp. 641-650
    • Kinney, M.A.1    Saeed, R.2    McDevitt, T.C.3
  • 35
    • 84855327822 scopus 로고    scopus 로고
    • Formation of embryoid bodies with controlled sizes and maintained pluripotency in three-dimensional inverse opal scaffolds
    • Y. Zhang, and Y. Xia Formation of embryoid bodies with controlled sizes and maintained pluripotency in three-dimensional inverse opal scaffolds Adv. Funct. Mater. 22 2012 121 129
    • (2012) Adv. Funct. Mater. , vol.22 , pp. 121-129
    • Zhang, Y.1    Xia, Y.2
  • 36
    • 33750156301 scopus 로고    scopus 로고
    • A multicellular spheroid array to realize spheroid formation, culture, and viability assay on a chip
    • DOI 10.1016/j.biomaterials.2006.08.054, PII S0142961206007848
    • Y.S. Torisawa, A. Takagi, Y. Nashimoto, T. Yasukawa, H. Shiku, and T. Matsue A multicellular spheroid array to realize spheroid formation, culture, and viability assay on a chip Biomaterials 28 2007 559 566 (Pubitemid 44602232)
    • (2007) Biomaterials , vol.28 , Issue.3 , pp. 559-566
    • Torisawa, Y.-s.1    Takagi, A.2    Nashimoto, Y.3    Yasukawa, T.4    Shiku, H.5    Matsue, T.6
  • 37
    • 84885147058 scopus 로고    scopus 로고
    • Inverse opal scaffolds for applications in regenerative medicine
    • Y.S. Zhang, S.W. Choi, and Y.N. Xia Inverse opal scaffolds for applications in regenerative medicine Soft Matter 9 2013 9747 9754
    • (2013) Soft Matter , vol.9 , pp. 9747-9754
    • Zhang, Y.S.1    Choi, S.W.2    Xia, Y.N.3
  • 39
    • 67649871487 scopus 로고    scopus 로고
    • In vitro toxicity testing of nanoparticles in 3D cell culture
    • J. Lee, G.D. Lilly, R.C. Doty, P. Podsiadlo, and N.A. Kotov In vitro toxicity testing of nanoparticles in 3D cell culture Small 5 2009 1213 1221
    • (2009) Small , vol.5 , pp. 1213-1221
    • Lee, J.1    Lilly, G.D.2    Doty, R.C.3    Podsiadlo, P.4    Kotov, N.A.5
  • 40
    • 69249230753 scopus 로고    scopus 로고
    • Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells
    • L.A. Gurski, A.K. Jha, C. Zhang, X. Jia, and M.C. Farach-Carson Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells Biomaterials 30 2009 6076 6085
    • (2009) Biomaterials , vol.30 , pp. 6076-6085
    • Gurski, L.A.1    Jha, A.K.2    Zhang, C.3    Jia, X.4    Farach-Carson, M.C.5
  • 42
    • 75749158184 scopus 로고    scopus 로고
    • Biomaterials offer cancer research the third dimension
    • D.W. Hutmacher Biomaterials offer cancer research the third dimension Nat. Mater. 9 2010 90 93
    • (2010) Nat. Mater. , vol.9 , pp. 90-93
    • Hutmacher, D.W.1
  • 44
    • 27944497333 scopus 로고    scopus 로고
    • Tissue cells feel and respond to the stiffness of their substrate
    • DOI 10.1126/science.1116995
    • D.E. Discher, P. Janmey, and Y.-l. Wang Tissue cells feel and respond to the stiffness of their substrate Science 310 2005 1139 1143 (Pubitemid 41681732)
    • (2005) Science , vol.310 , Issue.5751 , pp. 1139-1143
    • Discher, D.E.1    Janmey, P.2    Wang, Y.-L.3
  • 48
    • 77950438544 scopus 로고    scopus 로고
    • Microfluidic cell culture systems for drug research
    • M.-H. Wu, S.-B. Huang, and G.-B. Lee Microfluidic cell culture systems for drug research Lab Chip 10 2010 939 956
    • (2010) Lab Chip , vol.10 , pp. 939-956
    • Wu, M.-H.1    Huang, S.-B.2    Lee, G.-B.3
  • 49
    • 38149024155 scopus 로고    scopus 로고
    • Development of perfusion-based micro 3-D cell culture platform and its application for high throughput drug testing
    • M.-H. Wu, S.-B. Huang, Z. Cui, Z. Cui, and G.-B. Lee Development of perfusion-based micro 3-D cell culture platform and its application for high throughput drug testing Sens. Actuators B 129 2008 231 240
    • (2008) Sens. Actuators B , vol.129 , pp. 231-240
    • Wu, M.-H.1    Huang, S.-B.2    Cui, Z.3    Cui, Z.4    Lee, G.-B.5
  • 51
    • 37849003252 scopus 로고    scopus 로고
    • Microbioreactors for high-throughput cytotoxicity assays
    • S.T. Yang, X. Zhang, and Y. Wen Microbioreactors for high-throughput cytotoxicity assays Curr. Opin. Drug Discov. Devel. 11 2008 111 127
    • (2008) Curr. Opin. Drug Discov. Devel. , vol.11 , pp. 111-127
    • Yang, S.T.1    Zhang, X.2    Wen, Y.3
  • 52
    • 79953002875 scopus 로고    scopus 로고
    • Biofabrication of a three-dimensional liver micro-organ as an in vitro drug metabolism model
    • C. Robert, E. Kamal, W. Honglu, and S. Wei Biofabrication of a three-dimensional liver micro-organ as an in vitro drug metabolism model Biofabrication 2 2010 045004
    • (2010) Biofabrication , vol.2 , pp. 045004
    • Robert, C.1    Kamal, E.2    Honglu, W.3    Wei, S.4
  • 53
    • 40349103280 scopus 로고    scopus 로고
    • Microfluidic self-assembly of tumor spheroids for anticancer drug discovery
    • DOI 10.1007/s10544-007-9125-8
    • L.Y. Wu, D. Di Carlo, and L.P. Lee Microfluidic self-assembly of tumor spheroids for anticancer drug discovery Biomed. Microdevices 10 2008 197 202 (Pubitemid 351337922)
    • (2008) Biomedical Microdevices , vol.10 , Issue.2 , pp. 197-202
    • Wu, L.Y.1    Di Carlo, D.2    Lee, L.P.3
  • 54
    • 77956102001 scopus 로고    scopus 로고
    • Droplet-based microfluidic system for multicellular tumor spheroid formation and anticancer drug testing
    • L. Yu, M.C. Chen, and K.C. Cheung Droplet-based microfluidic system for multicellular tumor spheroid formation and anticancer drug testing Lab Chip 10 2010 2424 2432
    • (2010) Lab Chip , vol.10 , pp. 2424-2432
    • Yu, L.1    Chen, M.C.2    Cheung, K.C.3
  • 55
    • 84862207235 scopus 로고    scopus 로고
    • Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow
    • H.J. Kim, D. Huh, G. Hamilton, and D.E. Ingber Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow Lab Chip 12 2012 2165 2174
    • (2012) Lab Chip , vol.12 , pp. 2165-2174
    • Kim, H.J.1    Huh, D.2    Hamilton, G.3    Ingber, D.E.4
  • 56
    • 37649009647 scopus 로고    scopus 로고
    • Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems
    • D. Huh, H. Fujioka, Y.C. Tung, N. Futai, R. Paine 3rd, J.B. Grotberg, and S. Takayama Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems Proc. Natl. Acad. Sci. U. S. A. 104 2007 18886 18891
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 18886-18891
    • Huh, D.1    Fujioka, H.2    Tung, Y.C.3    Futai, N.4    Paine III, R.5    Grotberg, J.B.6    Takayama, S.7
  • 57
    • 76849115212 scopus 로고    scopus 로고
    • In vitro microscale systems for systematic drug toxicity study
    • J. Sung, and M. Shuler In vitro microscale systems for systematic drug toxicity study Bioprocess Biosyst. Eng. 33 2010 5 19
    • (2010) Bioprocess Biosyst. Eng. , vol.33 , pp. 5-19
    • Sung, J.1    Shuler, M.2
  • 58
    • 1142293800 scopus 로고    scopus 로고
    • The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors
    • DOI 10.1021/bp034077d
    • A. Sin, K.C. Chin, M.F. Jamil, Y. Kostov, G. Rao, and M.L. Shuler The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors Biotechnol. Prog. 20 2004 338 345 (Pubitemid 38204206)
    • (2004) Biotechnology Progress , vol.20 , Issue.1 , pp. 338-345
    • Sin, A.1    Chin, K.C.2    Jamil, M.F.3    Kostov, Y.4    Rao, G.5    Shuler, M.L.6
  • 61
    • 84871635879 scopus 로고    scopus 로고
    • Microfluidic system for facilitated quantification of nanoparticle accumulation to cells under laminar flow
    • J. Kusunose, H. Zhang, M.K. Gagnon, T. Pan, S.I. Simon, and K.W. Ferrara Microfluidic system for facilitated quantification of nanoparticle accumulation to cells under laminar flow Ann. Biomed. Eng. 41 2013 89 99
    • (2013) Ann. Biomed. Eng. , vol.41 , pp. 89-99
    • Kusunose, J.1    Zhang, H.2    Gagnon, M.K.3    Pan, T.4    Simon, S.I.5    Ferrara, K.W.6
  • 62
    • 84893235831 scopus 로고    scopus 로고
    • On-chip evaluation of platelet adhesion and aggregation upon exposure to mesoporous silica nanoparticles
    • D. Kim, S. Finkenstaedt-Quinn, K.R. Hurley, J.T. Buchman, and C.L. Haynes On-chip evaluation of platelet adhesion and aggregation upon exposure to mesoporous silica nanoparticles Analyst 135 2014 906 913
    • (2014) Analyst , vol.135 , pp. 906-913
    • Kim, D.1    Finkenstaedt-Quinn, S.2    Hurley, K.R.3    Buchman, J.T.4    Haynes, C.L.5
  • 64
    • 76149138872 scopus 로고    scopus 로고
    • Technique for real-time measurements of endothelial permeability in a microfluidic membrane chip using laser-induced fluorescence detection
    • E.W. Young, M.W. Watson, S. Srigunapalan, A.R. Wheeler, and C.A. Simmons Technique for real-time measurements of endothelial permeability in a microfluidic membrane chip using laser-induced fluorescence detection Anal. Chem. 82 2010 808 816
    • (2010) Anal. Chem. , vol.82 , pp. 808-816
    • Young, E.W.1    Watson, M.W.2    Srigunapalan, S.3    Wheeler, A.R.4    Simmons, C.A.5
  • 65
    • 84883205556 scopus 로고    scopus 로고
    • Adhesive interaction of functionalized particles and endothelium in idealized microvascular networks
    • G. Lamberti, Y. Tang, B. Prabhakarpandian, Y. Wang, K. Pant, M.F. Kiani, and B. Wang Adhesive interaction of functionalized particles and endothelium in idealized microvascular networks Microvasc. Res. 89 2013 107 114
    • (2013) Microvasc. Res. , vol.89 , pp. 107-114
    • Lamberti, G.1    Tang, Y.2    Prabhakarpandian, B.3    Wang, Y.4    Pant, K.5    Kiani, M.F.6    Wang, B.7
  • 66
    • 77955413581 scopus 로고    scopus 로고
    • Flow and adhesion of drug carriers in blood vessels depend on their shape: A study using model synthetic microvascular networks
    • N. Doshi, B. Prabhakarpandian, A. Rea-Ramsey, K. Pant, S. Sundaram, and S. Mitragotri Flow and adhesion of drug carriers in blood vessels depend on their shape: a study using model synthetic microvascular networks J. Control. Release 146 2010 196 200
    • (2010) J. Control. Release , vol.146 , pp. 196-200
    • Doshi, N.1    Prabhakarpandian, B.2    Rea-Ramsey, A.3    Pant, K.4    Sundaram, S.5    Mitragotri, S.6
  • 68
    • 84874404293 scopus 로고    scopus 로고
    • Margination propensity of vascular-targeted spheres from blood flow in a microfluidic model of human microvessels
    • K. Namdee, A.J. Thompson, P. Charoenphol, and O. Eniola-Adefeso Margination propensity of vascular-targeted spheres from blood flow in a microfluidic model of human microvessels Langmuir 29 2013 2530 2535
    • (2013) Langmuir , vol.29 , pp. 2530-2535
    • Namdee, K.1    Thompson, A.J.2    Charoenphol, P.3    Eniola-Adefeso, O.4
  • 71
    • 42549096933 scopus 로고    scopus 로고
    • Microfluidic delivery of small molecules into mammalian cells based on hydrodynamic focusing
    • DOI 10.1002/bit.21737
    • F. Wang, H. Wang, J. Wang, H.-Y. Wang, P.L. Rummel, S.V. Garimella, and C. Lu Microfluidic delivery of small molecules into mammalian cells based on hydrodynamic focusing Biotechnol. Bioeng. 100 2008 150 158 (Pubitemid 351579025)
    • (2008) Biotechnology and Bioengineering , vol.100 , Issue.1 , pp. 150-158
    • Wang, F.1    Wang, H.2    Wang, J.3    Wang, H.-Y.4    Rummel, P.L.5    Garimella, S.V.6    Lu, C.7
  • 73
    • 77954963854 scopus 로고    scopus 로고
    • Retrospective review of digoxin exposures to a poison control system following recall of Digitek(R) tablets
    • S.P. Nordt, A. Minns, C. Tomaszewski, F.L. Cantrell, and R.F. Clark Retrospective review of digoxin exposures to a poison control system following recall of Digitek(R) tablets Am. J. Cardiovasc. Drugs 10 2010 261 263
    • (2010) Am. J. Cardiovasc. Drugs , vol.10 , pp. 261-263
    • Nordt, S.P.1    Minns, A.2    Tomaszewski, C.3    Cantrell, F.L.4    Clark, R.F.5
  • 74
    • 79955102315 scopus 로고    scopus 로고
    • Patterned cardiomyocytes on microelectrode arrays as a functional, high information content drug screening platform
    • A. Natarajan, M. Stancescu, V. Dhir, C. Armstrong, F. Sommerhage, J.J. Hickman, and P. Molnar Patterned cardiomyocytes on microelectrode arrays as a functional, high information content drug screening platform Biomaterials 32 2011 4267 4274
    • (2011) Biomaterials , vol.32 , pp. 4267-4274
    • Natarajan, A.1    Stancescu, M.2    Dhir, V.3    Armstrong, C.4    Sommerhage, F.5    Hickman, J.J.6    Molnar, P.7
  • 75
    • 84857964726 scopus 로고    scopus 로고
    • Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip
    • A. Grosberg, P.W. Alford, M.L. McCain, and K.K. Parker Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip Lab Chip 11 2011 4165 4173
    • (2011) Lab Chip , vol.11 , pp. 4165-4173
    • Grosberg, A.1    Alford, P.W.2    McCain, M.L.3    Parker, K.K.4
  • 77
    • 84890794015 scopus 로고    scopus 로고
    • Modeling heart disease in a dish: From somatic cells to disease-relevant cardiomyocytes
    • F. Zanella, R.C. Lyon, and F. Sheikh Modeling heart disease in a dish: from somatic cells to disease-relevant cardiomyocytes Trends Cardiovasc. Med. 24 2014 32 44
    • (2014) Trends Cardiovasc. Med. , vol.24 , pp. 32-44
    • Zanella, F.1    Lyon, R.C.2    Sheikh, F.3
  • 79
    • 38949168818 scopus 로고    scopus 로고
    • Perfusion-decellularized matrix: Using nature's platform to engineer a bioartificial heart
    • DOI 10.1038/nm1684, PII NM1684
    • H.C. Ott, T.S. Matthiesen, S.K. Goh, L.D. Black, S.M. Kren, T.I. Netoff, and D.A. Taylor Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart Nat. Med. 14 2008 213 221 (Pubitemid 351214548)
    • (2008) Nature Medicine , vol.14 , Issue.2 , pp. 213-221
    • Ott, H.C.1    Matthiesen, T.S.2    Goh, S.-K.3    Black, L.D.4    Kren, S.M.5    Netoff, T.I.6    Taylor, D.A.7
  • 80
    • 66249089481 scopus 로고    scopus 로고
    • Scaffold-free human cardiac tissue patch created from embryonic stem cells
    • K.R. Stevens, L. Pabon, V. Muskheli, and C.E. Murry Scaffold-free human cardiac tissue patch created from embryonic stem cells Tissue Eng. Part A 15 2009 1211 1222
    • (2009) Tissue Eng. Part A , vol.15 , pp. 1211-1222
    • Stevens, K.R.1    Pabon, L.2    Muskheli, V.3    Murry, C.E.4
  • 81
    • 0037155176 scopus 로고    scopus 로고
    • Fabrication of pulsatile cardiac tissue grafts using a novel 3-dimensional cell sheet manipulation technique and temperature-responsive cell culture surfaces
    • T. Shimizu, M. Yamato, Y. Isoi, T. Akutsu, T. Setomaru, K. Abe, A. Kikuchi, M. Umezu, and T. Okano Fabrication of pulsatile cardiac tissue grafts using a novel 3-dimensional cell sheet manipulation technique and temperature-responsive cell culture surfaces Circ. Res. 90 2002 e40
    • (2002) Circ. Res. , vol.90 , pp. 40
    • Shimizu, T.1    Yamato, M.2    Isoi, Y.3    Akutsu, T.4    Setomaru, T.5    Abe, K.6    Kikuchi, A.7    Umezu, M.8    Okano, T.9
  • 83
    • 84882240631 scopus 로고    scopus 로고
    • Microfluidic heart on a chip for higher throughput pharmacological studies
    • A. Agarwal, J.A. Goss, A. Cho, M.L. McCain, and K.K. Parker Microfluidic heart on a chip for higher throughput pharmacological studies Lab Chip 13 2013 3599 3608
    • (2013) Lab Chip , vol.13 , pp. 3599-3608
    • Agarwal, A.1    Goss, J.A.2    Cho, A.3    McCain, M.L.4    Parker, K.K.5
  • 84
    • 84856709730 scopus 로고    scopus 로고
    • Reversible alteration of calcium dynamics in cardiomyocytes during acute hypoxia transient in a microfluidic platform
    • S. Martewicz, F. Michielin, E. Serena, A. Zambon, M. Mongillo, and N. Elvassore Reversible alteration of calcium dynamics in cardiomyocytes during acute hypoxia transient in a microfluidic platform Integr. Biol. (Camb.) 4 2012 153 164
    • (2012) Integr. Biol. (Camb.) , vol.4 , pp. 153-164
    • Martewicz, S.1    Michielin, F.2    Serena, E.3    Zambon, A.4    Mongillo, M.5    Elvassore, N.6
  • 85
    • 20844444779 scopus 로고    scopus 로고
    • Idiosyncratic drug hepatotoxicity
    • DOI 10.1038/nrd1750
    • N. Kaplowitz Idiosyncratic drug hepatotoxicity Nat. Rev. Drug Discov. 4 2005 489 499 (Pubitemid 40861991)
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.6 , pp. 489-499
    • Kaplowitz, N.1
  • 86
    • 38049011979 scopus 로고    scopus 로고
    • Microscale culture of human liver cells for drug development
    • S.R. Khetani, and S.N. Bhatia Microscale culture of human liver cells for drug development Nat. Biotechnol. 26 2008 120 126
    • (2008) Nat. Biotechnol. , vol.26 , pp. 120-126
    • Khetani, S.R.1    Bhatia, S.N.2
  • 88
    • 84876320133 scopus 로고    scopus 로고
    • A multicellular 3D heterospheroid model of liver tumor and stromal cells in collagen gel for anti-cancer drug testing
    • D. Yip, and C.H. Cho A multicellular 3D heterospheroid model of liver tumor and stromal cells in collagen gel for anti-cancer drug testing Biochem. Biophys. Res. Commun. 433 2013 327 332
    • (2013) Biochem. Biophys. Res. Commun. , vol.433 , pp. 327-332
    • Yip, D.1    Cho, C.H.2
  • 89
    • 67650481611 scopus 로고    scopus 로고
    • A microfluidic 3D hepatocyte chip for drug toxicity testing
    • Y.C. Toh, T.C. Lim, D. Tai, G. Xiao, D. van Noort, and H. Yu A microfluidic 3D hepatocyte chip for drug toxicity testing Lab Chip 9 2009 2026 2035
    • (2009) Lab Chip , vol.9 , pp. 2026-2035
    • Toh, Y.C.1    Lim, T.C.2    Tai, D.3    Xiao, G.4    Van Noort, D.5    Yu, H.6
  • 91
    • 84878343303 scopus 로고    scopus 로고
    • Student award winner in the Ph.D. Category for the 2013 society for biomaterials annual meeting and exposition, April 10-13, 2013, Boston, Massachusetts: Biomaterial-mediated cancer-specific DNA delivery to liver cell cultures using synthetic poly(beta-amino ester)s
    • S.Y. Tzeng, L.J. Higgins, M.G. Pomper, and J.J. Green Student award winner in the Ph.D. category for the 2013 society for biomaterials annual meeting and exposition, April 10-13, 2013, Boston, Massachusetts: biomaterial-mediated cancer-specific DNA delivery to liver cell cultures using synthetic poly(beta-amino ester)s J. Biomed. Mater. Res. A 101 2013 1837 1845
    • (2013) J. Biomed. Mater. Res. A , vol.101 , pp. 1837-1845
    • Tzeng, S.Y.1    Higgins, L.J.2    Pomper, M.G.3    Green, J.J.4
  • 96
    • 77957671875 scopus 로고    scopus 로고
    • A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices
    • P.M. van Midwoud, M.T. Merema, E. Verpoorte, and G.M. Groothuis A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices Lab Chip 10 2010 2778 2786
    • (2010) Lab Chip , vol.10 , pp. 2778-2786
    • Van Midwoud, P.M.1    Merema, M.T.2    Verpoorte, E.3    Groothuis, G.M.4
  • 98
    • 80052351691 scopus 로고    scopus 로고
    • Concave microwell based size-controllable hepatosphere as a three-dimensional liver tissue model
    • S.F. Wong, Y. No da, Y.Y. Choi, D.S. Kim, B.G. Chung, and S.H. Lee Concave microwell based size-controllable hepatosphere as a three-dimensional liver tissue model Biomaterials 32 2011 8087 8096
    • (2011) Biomaterials , vol.32 , pp. 8087-8096
    • Wong, S.F.1    No Da, Y.2    Choi, Y.Y.3    Kim, D.S.4    Chung, B.G.5    Lee, S.H.6
  • 100
    • 78649509613 scopus 로고    scopus 로고
    • Perfusion-based microfluidic device for three-dimensional dynamic primary human hepatocyte cell culture in the absence of biological or synthetic matrices or coagulants
    • V.N. Goral, Y.C. Hsieh, O.N. Petzold, J.S. Clark, P.K. Yuen, and R.A. Faris Perfusion-based microfluidic device for three-dimensional dynamic primary human hepatocyte cell culture in the absence of biological or synthetic matrices or coagulants Lab Chip 10 2010 3380 3386
    • (2010) Lab Chip , vol.10 , pp. 3380-3386
    • Goral, V.N.1    Hsieh, Y.C.2    Petzold, O.N.3    Clark, J.S.4    Yuen, P.K.5    Faris, R.A.6
  • 101
    • 65649133932 scopus 로고    scopus 로고
    • A micro cell culture analog (μCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs
    • J.H. Sung, and M.L. Shuler A micro cell culture analog (μCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs Lab Chip 9 2009 1385 1394
    • (2009) Lab Chip , vol.9 , pp. 1385-1394
    • Sung, J.H.1    Shuler, M.L.2
  • 104
    • 0344513087 scopus 로고    scopus 로고
    • Pulmonary drug delivery. Part I: Physiological factors affecting therapeutic effectiveness of aerosolized medications
    • DOI 10.1046/j.1365-2125.2003.01892.x
    • N.R. Labiris, and M.B. Dolovich Pulmonary drug delivery, part I: physiological factors affecting therapeutic effectiveness of aerosolized medications Br. J. Clin. Pharmacol. 56 2003 588 599 (Pubitemid 37491710)
    • (2003) British Journal of Clinical Pharmacology , vol.56 , Issue.6 , pp. 588-599
    • Labiris, N.R.1    Dolovich, M.B.2
  • 106
    • 84866045532 scopus 로고    scopus 로고
    • A review of mammalian toxicity of ZnO nanoparticles
    • R.J. Vandebriel, and W.H. De Jong A review of mammalian toxicity of ZnO nanoparticles Nanotechnol. Sci. Appl. 5 2012 61 71
    • (2012) Nanotechnol. Sci. Appl. , vol.5 , pp. 61-71
    • Vandebriel, R.J.1    De Jong, W.H.2
  • 107
    • 84873939652 scopus 로고    scopus 로고
    • Silver nanoparticles of Albizia adianthifolia: The induction of apoptosis in human lung carcinoma cell line
    • R. Govender, A. Phulukdaree, R.M. Gengan, K. Anand, and A.A. Chuturgoon Silver nanoparticles of Albizia adianthifolia: the induction of apoptosis in human lung carcinoma cell line J. Nanobiotechnol. 11 2013 5
    • (2013) J. Nanobiotechnol. , vol.11 , pp. 5
    • Govender, R.1    Phulukdaree, A.2    Gengan, R.M.3    Anand, K.4    Chuturgoon, A.A.5
  • 108
    • 84863116456 scopus 로고    scopus 로고
    • Nano-sized albumin-copolymer micelles for efficient doxorubicin delivery
    • Y. Wu, E.K. Shih, A. Ramanathan, S. Vasudevan, and T. Weil Nano-sized albumin-copolymer micelles for efficient doxorubicin delivery Biointerphases 7 2012 5
    • (2012) Biointerphases , vol.7 , pp. 5
    • Wu, Y.1    Shih, E.K.2    Ramanathan, A.3    Vasudevan, S.4    Weil, T.5
  • 109
    • 84893789928 scopus 로고    scopus 로고
    • Novel self-assembly endows human serum albumin nanoparticles with an enhanced antitumor efficacy
    • D. Ding, X. Tang, X. Cao, J. Wu, A. Yuan, Q. Qiao, J. Pan, and Y. Hu Novel self-assembly endows human serum albumin nanoparticles with an enhanced antitumor efficacy AAPS PharmSciTech 15 2013 213 222
    • (2013) AAPS PharmSciTech , vol.15 , pp. 213-222
    • Ding, D.1    Tang, X.2    Cao, X.3    Wu, J.4    Yuan, A.5    Qiao, Q.6    Pan, J.7    Hu, Y.8
  • 111
    • 72049119863 scopus 로고    scopus 로고
    • Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments
    • C. Zhang, Z. Zhao, N.A. Abdul Rahim, D. van Noort, and H. Yu Towards a human-on-chip: culturing multiple cell types on a chip with compartmentalized microenvironments Lab Chip 9 2009 3185 3192
    • (2009) Lab Chip , vol.9 , pp. 3185-3192
    • Zhang, C.1    Zhao, Z.2    Abdul Rahim, N.A.3    Van Noort, D.4    Yu, H.5
  • 114
    • 84891358668 scopus 로고    scopus 로고
    • Delivering nanoparticles to lungs while avoiding liver and spleen through adsorption on red blood cells
    • A.C. Anselmo, V. Gupta, B.J. Zern, D. Pan, M. Zakrewsky, V. Muzykantov, and S. Mitragotri Delivering nanoparticles to lungs while avoiding liver and spleen through adsorption on red blood cells ACS Nano 7 2013 11129 11137
    • (2013) ACS Nano , vol.7 , pp. 11129-11137
    • Anselmo, A.C.1    Gupta, V.2    Zern, B.J.3    Pan, D.4    Zakrewsky, M.5    Muzykantov, V.6    Mitragotri, S.7
  • 115
    • 33947265152 scopus 로고    scopus 로고
    • An improved in vitro model of human intestinal follicle-associated epithelium to study nanoparticle transport by M cells
    • DOI 10.1016/j.ejps.2006.12.006, PII S092809870700005X
    • A. des Rieux, V. Fievez, I. Theate, J. Mast, V. Preat, and Y.J. Schneider An improved in vitro model of human intestinal follicle-associated epithelium to study nanoparticle transport by M cells Eur. J. Pharm. Sci. 30 2007 380 391 (Pubitemid 46436454)
    • (2007) European Journal of Pharmaceutical Sciences , vol.30 , Issue.5 , pp. 380-391
    • Des Rieux, A.1    Fievez, V.2    Theate, I.3    Mast, J.4    Preat, V.5    Schneider, Y.-J.6
  • 116
    • 0036389869 scopus 로고    scopus 로고
    • The autonomic nervous system and pressure-natriuresis in cardiovascular-renal interactions in response to salt
    • E.J. Johns The autonomic nervous system and pressure-natriuresis in cardiovascular-renal interactions in response to salt Clin. Auton. Res. 12 2002 256 263
    • (2002) Clin. Auton. Res. , vol.12 , pp. 256-263
    • Johns, E.J.1
  • 117
    • 84899152739 scopus 로고    scopus 로고
    • The physical basis of renal fibrosis: Effects of altered hydrodynamic forces on kidney homeostasis
    • B.M. Grabias, and K. Konstantopoulos The physical basis of renal fibrosis: effects of altered hydrodynamic forces on kidney homeostasis Am. J. Physiol. Renal Physiol. 306 2013 F473 F485
    • (2013) Am. J. Physiol. Renal Physiol. , vol.306
    • Grabias, B.M.1    Konstantopoulos, K.2
  • 121
    • 65349174488 scopus 로고    scopus 로고
    • Micromagnetic-microfluidic blood cleansing device
    • C.W. Yung, J. Fiering, A.J. Mueller, and D.E. Ingber Micromagnetic- microfluidic blood cleansing device Lab Chip 9 2009 1171 1177
    • (2009) Lab Chip , vol.9 , pp. 1171-1177
    • Yung, C.W.1    Fiering, J.2    Mueller, A.J.3    Ingber, D.E.4
  • 122
    • 4944266313 scopus 로고    scopus 로고
    • High interstitial fluid pressure - An obstacle in cancer therapy
    • DOI 10.1038/nrc1456
    • C.H. Heldin, K. Rubin, K. Pietras, and A. Ostman High interstitial fluid pressure - an obstacle in cancer therapy Nat. Rev. Cancer 4 2004 806 813 (Pubitemid 39331152)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.10 , pp. 806-813
    • Heldin, C.-H.1    Rubin, K.2    Pietras, K.3    Ostman, A.4
  • 124
    • 84882663856 scopus 로고    scopus 로고
    • Cells, tissues, and organs on chips: Challenges and opportunities for the cancer tumor microenvironment
    • E.W. Young Cells, tissues, and organs on chips: challenges and opportunities for the cancer tumor microenvironment Integr. Biol. (Camb.) 5 2013 1096 1109
    • (2013) Integr. Biol. (Camb.) , vol.5 , pp. 1096-1109
    • Young, E.W.1
  • 125
    • 69349103437 scopus 로고    scopus 로고
    • Microfluidic chip: Next-generation platform for systems biology
    • X. Feng, W. Du, Q. Luo, and B.F. Liu Microfluidic chip: next-generation platform for systems biology Anal. Chim. Acta 650 2009 83 97
    • (2009) Anal. Chim. Acta , vol.650 , pp. 83-97
    • Feng, X.1    Du, W.2    Luo, Q.3    Liu, B.F.4


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