Microfluidic system for facilitated quantification of nanoparticle accumulation to cells under laminar flow

Annals of Biomedical Engineering

Volumn 41, Issue 1, 2013, Pages 89-99

  Kusunose, Jiro ^a   Zhang, Hua ^a   Gagnon, M Karen J ^a   Pan, Tingrui ^a   Simon, Scott I ^a   Ferrara, Katherine W ^a  

^a University of California   (United States)

Author keywords

Aminopeptidase N; HUVEC; Lipo PEG peptide; Liposomes; VCAM 1

Indexed keywords

AFFINITY LIGANDS; AMINO PEPTIDASE; COST-EFFECTIVE METHODS; ENDOTHELIAL RECEPTOR; FLOW CHAMBER MODELS; HUVEC; IMAGING PROBE; IN-VITRO; LIGAND CONCENTRATION; LIPO-PEG-PEPTIDE; MICRO FLUIDIC SYSTEM; MICROFLUIDIC CHAMBERS; PARTICLE ACCUMULATION; PARTICLE BINDING; PETRI DISH; SHEAR ENVIRONMENTS; SURFACE AREA; TARGETED NANOPARTICLE; VCAM-1;

LAMINAR FLOW; LIPOSOMES; NANOPARTICLES; OPTIMIZATION; PEPTIDES;

LIGANDS;

LIGAND; LIPOSOME; MICROSOMAL AMINOPEPTIDASE; MONOCLONAL ANTIBODY; NANOPARTICLE; OLIGOPEPTIDE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CHEMISTRY; HUMAN; METABOLISM; MICROFLUIDICS; UMBILICAL VEIN ENDOTHELIAL CELL;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD13; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LIGANDS; LIPOSOMES; MICROFLUIDICS; NANOPARTICLES; OLIGOPEPTIDES; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84871635879     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-012-0634-0     Document Type: Article

References (29)

1. Chang, K. C., and D. A. Hammer. The forward rate of binding of surface-tethered reactants: effect of relative motion between two surfaces. Biophys. J. 76:1280-1292, 1999. (Pubitemid 29262610)
2. Charoenphol, P., R. B. Huang, and O. Eniola-Adefeso. Potential role of size and hemodynamics in the efficacy of vascular-targeted spherical drug carriers. Biomaterials 31:1392-1402, 2010.
3. Chen, A. N., and T. R. Pan. Three-dimensional fit-to-flow microfluidic assembly. Biomicrofluidics 5:46505-46509, 2011.
4. Evans, E., and K. Kinoshita. Using force to probe single-molecule receptor-cytoskeletal anchoring beneath the surface of a living cell. Methods Cell Biol. 83:373-396, 2007.
5. Farokhzad, O. C., A. Khademhosseini, S. Jon, A. Hermmann, J. Cheng, C. Chin, A. Kiselyuk, B. Teply, G. Eng, and R. Langer. Microfluidic system for studying the interaction of nanoparticles and microparticles with cells. Anal. Chem. 77:5453-5459, 2005. (Pubitemid 41266036)
6. Harris, S. S., and T. D. Giorgio. Convective flow increases lipoplex delivery rate to in vitro cellular monolayers. Gene Ther. 12:512-520, 2005. (Pubitemid 40439551)
7. Jeong, J. H., M. Lee, W. J. Kim, J. W. Yockman, T. G. Park, Y. H. Kim, and S. W. Kim. Anti-GAD antibody targeted non-viral gene delivery to islet beta cells. J. Controlled Release 107:562-570, 2005. (Pubitemid 41393362)
8. Kelly, K. A., M. Nahrendorf, A. M. Yu, F. Reynolds, and R. Weissleder. In vivo phage display selection yields atherosclerotic plaque targeted peptides for imaging. Mol. Imaging Biol. 8:201-207, 2006. (Pubitemid 44193415)
9. Klibanov, A. L., K. Maruyama, V. P. Torchilin, and L. Huang. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett. 268:235-237, 1990. (Pubitemid 20233874)
10. Korn, C. B., and U. S. Schwarz. Mean first passage times for bond formation for a Brownian particle in linear shear flow above a wall. J. Chem. Phys. 126:095103, 2007. (Pubitemid 46385647)
11. Kuo, S. C., and D. A. Lauffenburger. Relationship between receptor/ligand binding affinity and adhesion strength. Biophys. J. 65:2191-2200, 1993. (Pubitemid 23334883)
12. Lee, S. Y., M. Ferrari, and P. Decuzzi. Shaping nano-/micro-particles for enhanced vascular interaction in laminar flows. Nanotechnology 20:495101, 2009.
13. Matsumura, Y., and H. Maeda. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent SMANCS. Cancer Res. 46:6387-6392, 1986. (Pubitemid 17221789)
14. Nahrendorf, M., F. A. Jaffer, K. A. Kelly, D. E. Sosnovik, E. Aikawa, P. Libby, and R. Weissleder. Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation 114:1504-1511, 2006. (Pubitemid 44527006)
15. Nahrendorf, M., E. Keliher, P. Panizzi, H. Zhang, S. Hembrador, J. L. Figueiredo, E. Aikawa, K. Kelly, P. Libby, and R. Weissleder. 18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis. JACC Cardiovasc. Imaging 2:1213-1222, 2009.
16. Papahadjopoulos, D., T. M. Allen, A. Gabizon, E. Mayhew, K. Matthay, S. K. Huang, K. D. Lee, M. C. Woodle, D. D. Lasic, C. Redemann, and F. J. Martin. Sterically stabilized liposomes - improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc. Natl Acad. Sci. U.S.A. 88:11460-11464, 1991. (Pubitemid 21916061)
17. Pasqualini, R., E. Koivunen, R. Kain, J. Lahdenranta, M. Sakamoto, A. Stryhn, R. A. Ashmun, L. H. Shapiro, W. Arap, and E. Ruoslahti. Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. Cancer Res. 60:722-727, 2000. (Pubitemid 30094573)
18. Plesniak, L. A., B. Salzameda, H. Hinderberger, E. Regan, J. Kahn, S. A. Mills, P. Teriete, Y. Yao, P. Jennings, F. Marassi, and J. A. Adams. Structure and activity of CPNGRC: a modified CD13/APN peptidic homing motif. Chem. Biol. Drug Des. 75:551-562, 2010.
19. Prabhakarpandian, B., Y. Wang, A. Rea-Ramsey, S. Sundaram, M. F. Kiani, and K. Pant. Bifurcations: focal points of particle adhesion in microvascular networks. Microcirculation 18:380-389, 2011.
20. Ruoslahti, E. Vascular zip codes in angiogenesis and metastasis. Biochem. Soc. Trans. 32:397-402, 2004. (Pubitemid 38813523)
21. Schaff, U. Y., M. M. Xing, K. K. Lin, N. Pan, N. L. Jeon, and S. I. Simon. Vascular mimetics based on microfluidics for imaging the leukocyte-endothelial inflammatory response. Lab Chip 7:448-456, 2007. (Pubitemid 46496555)
22. Smith, M. L., M. J. Smith, M. B. Lawrence, and K. Ley. Viscosity-independent velocity of neutrophils rolling on p-selectin in vitro or in vivo. Microcirculation 9:523-536, 2002. (Pubitemid 135684862)
23. Tsou, J. K., R. M. Gower, H. J. Ting, U. Y. Schaff, M. F. Insana, A. G. Passerini, and S. I. Simon. Spatial regulation of inflammation by human aortic endothelial cells in a linear gradient of shear stress. Microcirculation 15:311-323, 2008. (Pubitemid 351903346)
24. Usami, S., H. H. Chen, Y. Zhao, S. Chien, and R. Skalak. Design and construction of a linear shear stress flow chamber. Ann. Biomed. Eng. 21:77-83, 1993.
25. Wattenbarger, M. R., D. J. Graves, and D. A. Lauffenburger. Specific adhesion of glycophorin liposomes to a lectin surface in shear flow. Biophys. J. 57:765-777, 1990. (Pubitemid 20111236)
26. Xia, Y. N., and G. M. Whitesides. Soft lithography. Annu. Rev. Mater. Sci. 28:153-184, 1998. (Pubitemid 128631417)
27. Zhang, H., J. Kusunose, A. Kheirolomoom, J. W. Seo, J. Qi, K. D. Watson, H. A. Lindfors, E. Ruoslahti, J. L. Sutcliffe, and K. W. Ferrara. Dynamic imaging of arginine-rich heart-targeted vehicles in a mouse model. Biomaterials 29:1976-1988, 2008.
28. Zhao, S., A. Chen, A. Revzin, and T. Pan. Stereomask lithography (SML): a universal multi-object micro-patterning technique for biological applications. Lab Chip 11:224-230, 2011.
29. Zhao, S., H. Cong, and T. Pan. Direct projection on dry-film photoresist (DP(2)): do-it-yourself three-dimensional polymer microfluidics. Lab Chip 9:1128-1132, 2009.