메뉴 건너뛰기




Volumn 33, Issue 1, 2010, Pages 5-19

In vitro microscale systems for systematic drug toxicity study

Author keywords

ADME; Microfluidics; Pharmacokinetics

Indexed keywords

ADME; ANIMAL STUDIES; CELL CULTURE TECHNIQUES; CLINICAL TRIAL; DRUG DEVELOPMENT; DRUG EFFECTS; DRUG SCREENING; DYNAMIC PROCESS; HIGH-THROUGHPUT; IN-VITRO; MICROSCALE SYSTEMS; PHARMACOLOGICAL RESPONSE; RESEARCH EFFORTS; TIME-DEPENDENT;

EID: 76849115212     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-009-0369-y     Document Type: Short Survey
Times cited : (71)

References (110)
  • 1
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • I Kola J Landis 2004 Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 3 711 715
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 2
    • 34548305252 scopus 로고    scopus 로고
    • Integrated pharmacokinetics and pharmacodynamics in drug development
    • J Dingemanse S Appel-Dingemanse 2007 Integrated pharmacokinetics and pharmacodynamics in drug development Clin Pharmacokinet 46 713 737
    • (2007) Clin Pharmacokinet , vol.46 , pp. 713-737
    • Dingemanse, J.1    Appel-Dingemanse, S.2
  • 3
    • 59349115917 scopus 로고    scopus 로고
    • 2008 FDA drug approvals
    • B Hughes 2009 2008 FDA drug approvals Nat Rev Drug Discov 8 93 96
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 93-96
    • Hughes, B.1
  • 4
    • 2442482962 scopus 로고    scopus 로고
    • Key factors in the rising cost of new drug discovery and development
    • M Dickson JP Gagnon 2004 Key factors in the rising cost of new drug discovery and development Nat Rev Drug Discov 3 417 429
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 417-429
    • Dickson, M.1    Gagnon, J.P.2
  • 5
    • 59149106151 scopus 로고    scopus 로고
    • Toxicity testing in the 21st century: Bringing the vision to life
    • ME Andersen D Krewski 2009 Toxicity testing in the 21st century: bringing the vision to life Toxicol Sci 107 324 330
    • (2009) Toxicol Sci , vol.107 , pp. 324-330
    • Andersen, M.E.1    Krewski, D.2
  • 6
    • 63249109982 scopus 로고    scopus 로고
    • High-throughput screening for analysis of in vitro toxicity
    • WG Schoonen WM Westerink GJ Horbach 2009 High-throughput screening for analysis of in vitro toxicity EXS 99 401 452
    • (2009) EXS , vol.99 , pp. 401-452
    • Schoonen, W.G.1    Westerink, W.M.2    Horbach, G.J.3
  • 8
    • 0037452445 scopus 로고    scopus 로고
    • Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection
    • FP Theil TW Guentert S Haddad P Poulin 2003 Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection Toxicol Lett 138 29 49
    • (2003) Toxicol Lett , vol.138 , pp. 29-49
    • Theil, F.P.1    Guentert, T.W.2    Haddad, S.3    Poulin, P.4
  • 9
    • 1942453306 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil
    • AB van Kuilenburg 2004 Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil Eur J Cancer 40 939 950
    • (2004) Eur J Cancer , vol.40 , pp. 939-950
    • Van Kuilenburg, A.B.1
  • 11
    • 0037357723 scopus 로고    scopus 로고
    • Integration of cell culture and microfabrication technology
    • TH Park ML Shuler 2003 Integration of cell culture and microfabrication technology Biotechnol Prog 19 243 253
    • (2003) Biotechnol Prog , vol.19 , pp. 243-253
    • Park, T.H.1    Shuler, M.L.2
  • 12
    • 18344372247 scopus 로고    scopus 로고
    • Labs on a chip: Meet the stripped down rat
    • R Khamsi 2005 Labs on a chip: meet the stripped down rat Nature 435 12 13
    • (2005) Nature , vol.435 , pp. 12-13
    • Khamsi, R.1
  • 13
    • 37849003252 scopus 로고    scopus 로고
    • Microbioreactors for high-throughput cytotoxicity assays
    • ST Yang X Zhang Y Wen 2008 Microbioreactors for high-throughput cytotoxicity assays Curr Opin Drug Discov Devel 11 111 127
    • (2008) Curr Opin Drug Discov Devel , vol.11 , pp. 111-127
    • Yang, S.T.1    Zhang, X.2    Wen, Y.3
  • 14
    • 2442704008 scopus 로고    scopus 로고
    • High cell density fed-batch cultivation of Escherichia coli using exponential feeding combined with pH-stat
    • BS Kim SC Lee SY Lee YK Chang HN Chang 2004 High cell density fed-batch cultivation of Escherichia coli using exponential feeding combined with pH-stat Bioprocess Biosyst Eng 26 147 150
    • (2004) Bioprocess Biosyst Eng , vol.26 , pp. 147-150
    • Kim, B.S.1    Lee, S.C.2    Lee, S.Y.3    Chang, Y.K.4    Chang, H.N.5
  • 15
    • 50249155247 scopus 로고    scopus 로고
    • Cell recycled culture of succinic acid-producing Anaerobiospirillum succiniciproducens using an internal membrane filtration system
    • PC Lee SY Lee HN Chang 2008 Cell recycled culture of succinic acid-producing Anaerobiospirillum succiniciproducens using an internal membrane filtration system J Microbiol Biotechnol 18 1252 1256
    • (2008) J Microbiol Biotechnol , vol.18 , pp. 1252-1256
    • Lee, P.C.1    Lee, S.Y.2    Chang, H.N.3
  • 16
    • 1942437993 scopus 로고    scopus 로고
    • Microenvironment design considerations for cellular scale studies
    • GM Walker HC Zeringue DJ Beebe 2004 Microenvironment design considerations for cellular scale studies Lab Chip 4 91 97
    • (2004) Lab Chip , vol.4 , pp. 91-97
    • Walker, G.M.1    Zeringue, H.C.2    Beebe, D.J.3
  • 18
    • 40349113355 scopus 로고    scopus 로고
    • A high throughput perfusion-based microbioreactor platform integrated with pneumatic micropumps for three-dimensional cell culture
    • MH Wu SB Huang Z Cui GB Lee 2008 A high throughput perfusion-based microbioreactor platform integrated with pneumatic micropumps for three-dimensional cell culture Biomed Microdev 10 309 319
    • (2008) Biomed Microdev , vol.10 , pp. 309-319
    • Wu, M.H.1    Huang, S.B.2    Cui, Z.3    Lee, G.B.4
  • 19
    • 48649091028 scopus 로고    scopus 로고
    • Pressure-driven perfusion culture microchamber array for a parallel drug cytotoxicity assay
    • S Sugiura J Edahiro K Kikuchi K Sumaru T Kanamori 2008 Pressure-driven perfusion culture microchamber array for a parallel drug cytotoxicity assay Biotechnol Bioeng 100 1156 1165
    • (2008) Biotechnol Bioeng , vol.100 , pp. 1156-1165
    • Sugiura, S.1    Edahiro, J.2    Kikuchi, K.3    Sumaru, K.4    Kanamori, T.5
  • 21
    • 42549106741 scopus 로고    scopus 로고
    • Automated cell culture in high density tubeless microfluidic device arrays
    • I Meyvantsson JW Warrick S Hayes A Skoien DJ Beebe 2008 Automated cell culture in high density tubeless microfluidic device arrays Lab Chip 8 717 724
    • (2008) Lab Chip , vol.8 , pp. 717-724
    • Meyvantsson, I.1    Warrick, J.W.2    Hayes, S.3    Skoien, A.4    Beebe, D.J.5
  • 22
    • 33847411140 scopus 로고    scopus 로고
    • High-throughput microfluidics: Improved sample treatment and washing over standard wells
    • J Warrick I Meyvantsson J Ju DJ Beebe 2007 High-throughput microfluidics: improved sample treatment and washing over standard wells Lab Chip 7 316 321
    • (2007) Lab Chip , vol.7 , pp. 316-321
    • Warrick, J.1    Meyvantsson, I.2    Ju, J.3    Beebe, D.J.4
  • 24
    • 57449118900 scopus 로고    scopus 로고
    • Dynamic cell culture: A microfluidic function generator for live cell microscopy
    • PJ Lee TA Gaige PJ Hung 2009 Dynamic cell culture: a microfluidic function generator for live cell microscopy Lab Chip 9 164 166
    • (2009) Lab Chip , vol.9 , pp. 164-166
    • Lee, P.J.1    Gaige, T.A.2    Hung, P.J.3
  • 25
    • 37349027919 scopus 로고    scopus 로고
    • Biomolecular gradients in cell culture systems
    • TM Keenan A Folch 2008 Biomolecular gradients in cell culture systems Lab Chip 8 34 57
    • (2008) Lab Chip , vol.8 , pp. 34-57
    • Keenan, T.M.1    Folch, A.2
  • 26
    • 84999274083 scopus 로고    scopus 로고
    • A microfluidic gradient maker for toxicity testing of bupivacaine and lidocaine
    • A Tirella M Marano F Vozzi A Ahluwalia 2008 A microfluidic gradient maker for toxicity testing of bupivacaine and lidocaine Toxicol In Vitro 22 1957 1964
    • (2008) Toxicol in Vitro , vol.22 , pp. 1957-1964
    • Tirella, A.1    Marano, M.2    Vozzi, F.3    Ahluwalia, A.4
  • 27
    • 12144263348 scopus 로고    scopus 로고
    • Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays
    • PJ Hung PJ Lee P Sabounchi R Lin LP Lee 2005 Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays Biotechnol Bioeng 89 1 8
    • (2005) Biotechnol Bioeng , vol.89 , pp. 1-8
    • Hung, P.J.1    Lee, P.J.2    Sabounchi, P.3    Lin, R.4    Lee, L.P.5
  • 28
    • 33646597792 scopus 로고    scopus 로고
    • Nanoliter scale microbioreactor array for quantitative cell biology
    • PJ Lee PJ Hung VM Rao LP Lee 2006 Nanoliter scale microbioreactor array for quantitative cell biology Biotechnol Bioeng 94 5 14
    • (2006) Biotechnol Bioeng , vol.94 , pp. 5-14
    • Lee, P.J.1    Hung, P.J.2    Rao, V.M.3    Lee, L.P.4
  • 32
    • 16544370893 scopus 로고    scopus 로고
    • Microbioreactor arrays with parametric control for high-throughput experimentation
    • MM Maharbiz WJ Holtz RT Howe JD Keasling 2004 Microbioreactor arrays with parametric control for high-throughput experimentation Biotechnol Bioeng 86 485 490
    • (2004) Biotechnol Bioeng , vol.86 , pp. 485-490
    • Maharbiz, M.M.1    Holtz, W.J.2    Howe, R.T.3    Keasling, J.D.4
  • 33
    • 34247863861 scopus 로고    scopus 로고
    • A parametric study of human fibroblasts culture in a microchannel bioreactor
    • N Korin A Bransky U Dinnar S Levenberg 2007 A parametric study of human fibroblasts culture in a microchannel bioreactor Lab Chip 7 611 617
    • (2007) Lab Chip , vol.7 , pp. 611-617
    • Korin, N.1    Bransky, A.2    Dinnar, U.3    Levenberg, S.4
  • 34
    • 33644648070 scopus 로고    scopus 로고
    • Microfluidic arrays for logarithmically perfused embryonic stem cell culture
    • L Kim MD Vahey HY Lee J Voldman 2006 Microfluidic arrays for logarithmically perfused embryonic stem cell culture Lab Chip 6 394 406
    • (2006) Lab Chip , vol.6 , pp. 394-406
    • Kim, L.1    Vahey, M.D.2    Lee, H.Y.3    Voldman, J.4
  • 35
    • 0042358985 scopus 로고    scopus 로고
    • Cell culture: Biology's new dimension
    • A Abbott 2003 Cell culture: biology's new dimension Nature 424 870 872
    • (2003) Nature , vol.424 , pp. 870-872
    • Abbott, A.1
  • 36
    • 34249947806 scopus 로고    scopus 로고
    • Materials science. Hydrogel cell cultures
    • MC Cushing KS Anseth 2007 Materials science. Hydrogel cell cultures Science 316 1133 1134
    • (2007) Science , vol.316 , pp. 1133-1134
    • Cushing, M.C.1    Anseth, K.S.2
  • 37
    • 0034234048 scopus 로고    scopus 로고
    • Microencapsulation of microbial cells
    • JK Park HN Chang 2000 Microencapsulation of microbial cells Biotechnol Adv 18 303 319
    • (2000) Biotechnol Adv , vol.18 , pp. 303-319
    • Park, J.K.1    Chang, H.N.2
  • 38
    • 0026738947 scopus 로고
    • Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells
    • OW Petersen L Ronnov-Jessen AR Howlett MJ Bissell 1992 Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells Proc Natl Acad Sci USA 89 9064 9068
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 9064-9068
    • Petersen, O.W.1    Ronnov-Jessen, L.2    Howlett, A.R.3    Bissell, M.J.4
  • 39
    • 17144424618 scopus 로고    scopus 로고
    • Biomimetic three-dimensional cultures significantly increase hematopoietic differentiation efficacy of embryonic stem cells
    • H Liu K Roy 2005 Biomimetic three-dimensional cultures significantly increase hematopoietic differentiation efficacy of embryonic stem cells Tissue Eng 11 319 330
    • (2005) Tissue Eng , vol.11 , pp. 319-330
    • Liu, H.1    Roy, K.2
  • 40
    • 33745766692 scopus 로고    scopus 로고
    • Enhancing the drug metabolism activities of C3A-a human hepatocyte cell line-by tissue engineering within alginate scaffolds
    • T Elkayam S Amitay-Shaprut M Dvir-Ginzberg T Harel S Cohen 2006 Enhancing the drug metabolism activities of C3A-a human hepatocyte cell line-by tissue engineering within alginate scaffolds Tissue Eng 12 1357 1368
    • (2006) Tissue Eng , vol.12 , pp. 1357-1368
    • Elkayam, T.1    Amitay-Shaprut, S.2    Dvir-Ginzberg, M.3    Harel, T.4    Cohen, S.5
  • 44
    • 56449113183 scopus 로고    scopus 로고
    • Microvalve-assisted patterning platform for measuring cellular dynamics based on 3D cell culture
    • MS Kim W Lee YC Kim JK Park 2008 Microvalve-assisted patterning platform for measuring cellular dynamics based on 3D cell culture Biotechnol Bioeng 101 1005 1013
    • (2008) Biotechnol Bioeng , vol.101 , pp. 1005-1013
    • Kim, M.S.1    Lee, W.2    Kim, Y.C.3    Park, J.K.4
  • 45
    • 33846032329 scopus 로고    scopus 로고
    • A microfluidic platform for 3-dimensional cell culture and cell-based assays
    • MS Kim JH Yeon JK Park 2007 A microfluidic platform for 3-dimensional cell culture and cell-based assays Biomed Microdev 9 25 34
    • (2007) Biomed Microdev , vol.9 , pp. 25-34
    • Kim, M.S.1    Yeon, J.H.2    Park, J.K.3
  • 46
    • 33746887011 scopus 로고    scopus 로고
    • Fabrication of cell-containing hydrogel microstructures inside microfluidic devices that can be used as cell-based biosensors
    • WG Koh MV Pishko 2006 Fabrication of cell-containing hydrogel microstructures inside microfluidic devices that can be used as cell-based biosensors Anal Bioanal Chem 385 1389 1397
    • (2006) Anal Bioanal Chem , vol.385 , pp. 1389-1397
    • Koh, W.G.1    Pishko, M.V.2
  • 47
    • 9644255820 scopus 로고    scopus 로고
    • Multi-channel 3-D cell culture device integrated on a silicon chip for anticancer drug sensitivity test
    • YS Torisawa H Shiku T Yasukawa M Nishizawa T Matsue 2005 Multi-channel 3-D cell culture device integrated on a silicon chip for anticancer drug sensitivity test Biomaterials 26 2165 2172
    • (2005) Biomaterials , vol.26 , pp. 2165-2172
    • Torisawa, Y.S.1    Shiku, H.2    Yasukawa, T.3    Nishizawa, M.4    Matsue, T.5
  • 48
    • 0018819839 scopus 로고
    • Acetaminophen toxicity in human lymphocytes in vitro
    • SP Spielberg 1980 Acetaminophen toxicity in human lymphocytes in vitro J Pharmacol Exp Ther 213 395 398
    • (1980) J Pharmacol Exp Ther , vol.213 , pp. 395-398
    • Spielberg, S.P.1
  • 49
    • 26844582163 scopus 로고    scopus 로고
    • A rapid in vitro assay for evaluation of metabolism-dependent cytotoxicity of antiepileptic drugs on isolated human lymphocytes
    • AR Tabatabaei RL Thies K Farrell FS Abbott 1997 A rapid in vitro assay for evaluation of metabolism-dependent cytotoxicity of antiepileptic drugs on isolated human lymphocytes Fundam Appl Toxicol 37 181 189
    • (1997) Fundam Appl Toxicol , vol.37 , pp. 181-189
    • Tabatabaei, A.R.1    Thies, R.L.2    Farrell, K.3    Abbott, F.S.4
  • 50
    • 28244478876 scopus 로고    scopus 로고
    • An in vitro approach to detect metabolite toxicity due to CYP3A4-dependent bioactivation of xenobiotics
    • L Vignati E Turlizzi S Monaci P Grossi R Kanter M Monshouwer 2005 An in vitro approach to detect metabolite toxicity due to CYP3A4-dependent bioactivation of xenobiotics Toxicology 216 154 167
    • (2005) Toxicology , vol.216 , pp. 154-167
    • Vignati, L.1    Turlizzi, E.2    Monaci, S.3    Grossi, P.4    Kanter, R.5    Monshouwer, M.6
  • 51
    • 0034973773 scopus 로고    scopus 로고
    • Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity
    • FP Guengerich 2001 Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity Chem Res Toxicol 14 611 650
    • (2001) Chem Res Toxicol , vol.14 , pp. 611-650
    • Guengerich, F.P.1
  • 54
    • 62749110786 scopus 로고    scopus 로고
    • Characterization of drug metabolites and cytotoxicity assay simultaneously using an integrated microfluidic device
    • B Ma G Zhang J Qin B Lin 2009 Characterization of drug metabolites and cytotoxicity assay simultaneously using an integrated microfluidic device Lab Chip 9 232 238
    • (2009) Lab Chip , vol.9 , pp. 232-238
    • Ma, B.1    Zhang, G.2    Qin, J.3    Lin, B.4
  • 55
    • 15244342411 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferases and clinical drug-drug interactions
    • TK Kiang MH Ensom TK Chang 2005 UDP-glucuronosyltransferases and clinical drug-drug interactions Pharmacol Ther 106 97 132
    • (2005) Pharmacol Ther , vol.106 , pp. 97-132
    • Kiang, T.K.1    Ensom, M.H.2    Chang, T.K.3
  • 56
    • 34547451586 scopus 로고    scopus 로고
    • A hybrid microdevice with a thin PDMS membrane on the detection window for UV absorbance detection
    • B Ma X Zhou G Wang Z Dai J Qin B Lin 2007 A hybrid microdevice with a thin PDMS membrane on the detection window for UV absorbance detection Electrophoresis 28 2474 2477
    • (2007) Electrophoresis , vol.28 , pp. 2474-2477
    • Ma, B.1    Zhou, X.2    Wang, G.3    Dai, Z.4    Qin, J.5    Lin, B.6
  • 57
    • 45249122800 scopus 로고    scopus 로고
    • Direct cell writing of 3D microorgan for in vitro pharmacokinetic model
    • R Chang J Nam W Sun 2008 Direct cell writing of 3D microorgan for in vitro pharmacokinetic model Tissue Eng Part C Methods 14 157 166
    • (2008) Tissue Eng Part C Methods , vol.14 , pp. 157-166
    • Chang, R.1    Nam, J.2    Sun, W.3
  • 58
    • 48949105651 scopus 로고    scopus 로고
    • In vitro evaluation of human xenobiotic toxicity: Scientific concepts and the novel integrated discrete multiple cell co-culture (IdMOC) technology
    • AP Li 2008 In vitro evaluation of human xenobiotic toxicity: scientific concepts and the novel integrated discrete multiple cell co-culture (IdMOC) technology ALTEX 25 43 49
    • (2008) ALTEX , vol.25 , pp. 43-49
    • Li, A.P.1
  • 59
    • 7444259030 scopus 로고    scopus 로고
    • A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity: Comparative cytotoxicity of tamoxifen towards normal human cells from five major organs and MCF-7 adenocarcinoma breast cancer cells
    • AP Li C Bode Y Sakai 2004 A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity: comparative cytotoxicity of tamoxifen towards normal human cells from five major organs and MCF-7 adenocarcinoma breast cancer cells Chem Biol Interact 150 129 136
    • (2004) Chem Biol Interact , vol.150 , pp. 129-136
    • Li, A.P.1    Bode, C.2    Sakai, Y.3
  • 60
    • 0034706904 scopus 로고    scopus 로고
    • In vitro toxicology in hepatocyte bioreactors-extracellular acidification rate (EAR) in a target cell line indicates hepato-activated transformation of substrates
    • HG Koebe CJ Deglmann R Metzger S Hoerrlein FW Schildberg 2000 In vitro toxicology in hepatocyte bioreactors-extracellular acidification rate (EAR) in a target cell line indicates hepato-activated transformation of substrates Toxicology 154 31 44
    • (2000) Toxicology , vol.154 , pp. 31-44
    • Koebe, H.G.1    Deglmann, C.J.2    Metzger, R.3    Hoerrlein, S.4    Schildberg, F.W.5
  • 61
    • 0020963903 scopus 로고
    • Physiologically based pharmacokinetic modeling: Principles and applications
    • LE Gerlowski RK Jain 1983 Physiologically based pharmacokinetic modeling: principles and applications J Pharm Sci 72 1103 1127
    • (1983) J Pharm Sci , vol.72 , pp. 1103-1127
    • Gerlowski, L.E.1    Jain, R.K.2
  • 62
    • 28244483121 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetic modelling: A sound mechanistic basis is needed
    • L Aarons 2005 Physiologically based pharmacokinetic modelling: a sound mechanistic basis is needed Br J Clin Pharmacol 60 581 583
    • (2005) Br J Clin Pharmacol , vol.60 , pp. 581-583
    • Aarons, L.1
  • 63
    • 33947507091 scopus 로고    scopus 로고
    • Computational systems biology in drug discovery and development: Methods and applications
    • W Materi DS Wishart 2007 Computational systems biology in drug discovery and development: methods and applications Drug Discov Today 12 295 303
    • (2007) Drug Discov Today , vol.12 , pp. 295-303
    • Materi, W.1    Wishart, D.S.2
  • 64
    • 0028998479 scopus 로고
    • A cell culture analogue of rodent physiology: Application to naphthalene toxicology
    • LM Sweeney ML Shuler JG Babish A Ghanem 1995 A cell culture analogue of rodent physiology: application to naphthalene toxicology Toxicol In vitro 9 307 316
    • (1995) Toxicol in Vitro , vol.9 , pp. 307-316
    • Sweeney, L.M.1    Shuler, M.L.2    Babish, J.G.3    Ghanem, A.4
  • 65
    • 0034041009 scopus 로고    scopus 로고
    • Characterization of a perfusion reactor utilizing mammalian cells on microcarrier beads
    • A Ghanem ML Shuler 2000 Characterization of a perfusion reactor utilizing mammalian cells on microcarrier beads Biotechnol Prog 16 471 479
    • (2000) Biotechnol Prog , vol.16 , pp. 471-479
    • Ghanem, A.1    Shuler, M.L.2
  • 66
    • 0034130030 scopus 로고    scopus 로고
    • Combining cell culture analogue reactor designs and PBPK models to probe mechanisms of naphthalene toxicity
    • A Ghanem ML Shuler 2000 Combining cell culture analogue reactor designs and PBPK models to probe mechanisms of naphthalene toxicity Biotechnol Prog 16 334 345
    • (2000) Biotechnol Prog , vol.16 , pp. 334-345
    • Ghanem, A.1    Shuler, M.L.2
  • 67
    • 0033136567 scopus 로고    scopus 로고
    • Use of in vitro data for construction of a physiologically based pharmacokinetic model for naphthalene in rats and mice to probe species differences
    • DJ Quick ML Shuler 1999 Use of in vitro data for construction of a physiologically based pharmacokinetic model for naphthalene in rats and mice to probe species differences Biotechnol Prog 15 540 555
    • (1999) Biotechnol Prog , vol.15 , pp. 540-555
    • Quick, D.J.1    Shuler, M.L.2
  • 68
    • 0030571207 scopus 로고    scopus 로고
    • A self-regulating cell culture analog device to mimic animal and human toxicological responses
    • ML Shuler A Ghanem D Quick MC Wong P Miller 1996 A self-regulating cell culture analog device to mimic animal and human toxicological responses Biotechnol Bioeng 52 45 60
    • (1996) Biotechnol Bioeng , vol.52 , pp. 45-60
    • Shuler, M.L.1    Ghanem, A.2    Quick, D.3    Wong, M.C.4    Miller, P.5
  • 69
    • 1142293800 scopus 로고    scopus 로고
    • The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors
    • A Sin KC Chin MF Jamil Y Kostov G Rao ML Shuler 2004 The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors Biotechnol Prog 20 338 345
    • (2004) Biotechnol Prog , vol.20 , pp. 338-345
    • Sin, A.1    Chin, K.C.2    Jamil, M.F.3    Kostov, Y.4    Rao, G.5    Shuler, M.L.6
  • 70
    • 1142305959 scopus 로고    scopus 로고
    • Development of a microscale cell culture analog to probe naphthalene toxicity
    • K Viravaidya A Sin ML Shuler 2004 Development of a microscale cell culture analog to probe naphthalene toxicity Biotechnol Prog 20 316 323
    • (2004) Biotechnol Prog , vol.20 , pp. 316-323
    • Viravaidya, K.1    Sin, A.2    Shuler, M.L.3
  • 71
    • 64749086511 scopus 로고    scopus 로고
    • A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers
    • DA Tatosian ML Shuler 2009 A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers Biotechnol Bioeng 103 187 198
    • (2009) Biotechnol Bioeng , vol.103 , pp. 187-198
    • Tatosian, D.A.1    Shuler, M.L.2
  • 72
    • 65649133932 scopus 로고    scopus 로고
    • A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs
    • JH Sung ML Shuler 2009 A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs Lab Chip 9 1385 1394
    • (2009) Lab Chip , vol.9 , pp. 1385-1394
    • Sung, J.H.1    Shuler, M.L.2
  • 74
    • 33845493309 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolic drug interactions
    • SE Leucuta L Vlase 2006 Pharmacokinetics and metabolic drug interactions Curr Clin Pharmacol 1 5 20
    • (2006) Curr Clin Pharmacol , vol.1 , pp. 5-20
    • Leucuta, S.E.1    Vlase, L.2
  • 78
    • 33745184675 scopus 로고    scopus 로고
    • Model-based analysis and design of a microchannel reactor for tissue engineering
    • K Mehta JJ Linderman 2006 Model-based analysis and design of a microchannel reactor for tissue engineering Biotechnol Bioeng 94 596 609
    • (2006) Biotechnol Bioeng , vol.94 , pp. 596-609
    • Mehta, K.1    Linderman, J.J.2
  • 79
    • 0035544007 scopus 로고    scopus 로고
    • Analysis of oxygen transport to hepatocytes in a flat-plate microchannel bioreactor
    • P Roy H Baskaran AW Tilles ML Yarmush M Toner 2001 Analysis of oxygen transport to hepatocytes in a flat-plate microchannel bioreactor Ann Biomed Eng 29 947 955
    • (2001) Ann Biomed Eng , vol.29 , pp. 947-955
    • Roy, P.1    Baskaran, H.2    Tilles, A.W.3    Yarmush, M.L.4    Toner, M.5
  • 80
    • 14844320510 scopus 로고    scopus 로고
    • In vitro zonation and toxicity in a hepatocyte bioreactor
    • JW Allen SR Khetani SN Bhatia 2005 In vitro zonation and toxicity in a hepatocyte bioreactor Toxicol Sci 84 110 119
    • (2005) Toxicol Sci , vol.84 , pp. 110-119
    • Allen, J.W.1    Khetani, S.R.2    Bhatia, S.N.3
  • 81
    • 37148998794 scopus 로고    scopus 로고
    • Induction of zone-like liver function gradients in HepG2 cells by varying culture medium height
    • JP Camp AT Capitano 2007 Induction of zone-like liver function gradients in HepG2 cells by varying culture medium height Biotechnol Prog 23 1485 1491
    • (2007) Biotechnol Prog , vol.23 , pp. 1485-1491
    • Camp, J.P.1    Capitano, A.T.2
  • 82
    • 0041695170 scopus 로고    scopus 로고
    • Cell culture in 3-dimensional microfluidic structure of PDMS (polydimethylsiloxane)
    • E Leclerc Y Sakai T Fujii 2003 Cell culture in 3-dimensional microfluidic structure of PDMS (polydimethylsiloxane) Biomed Microdevices 5 109 114
    • (2003) Biomed Microdevices , vol.5 , pp. 109-114
    • Leclerc, E.1    Sakai, Y.2    Fujii, T.3
  • 83
    • 2942709867 scopus 로고    scopus 로고
    • Microfluidic PDMS (polydimethylsiloxane) bioreactor for large-scale culture of hepatocytes
    • E Leclerc Y Sakai T Fujii 2004 Microfluidic PDMS (polydimethylsiloxane) bioreactor for large-scale culture of hepatocytes Biotechnol Prog 20 750 755
    • (2004) Biotechnol Prog , vol.20 , pp. 750-755
    • Leclerc, E.1    Sakai, Y.2    Fujii, T.3
  • 84
    • 3042614049 scopus 로고    scopus 로고
    • Perfusion culture of fetal human hepatocytes in microfluidic environments
    • E Leclerc Y Sakai T Fujii 2004 Perfusion culture of fetal human hepatocytes in microfluidic environments Biochem Eng J 20 143 148
    • (2004) Biochem Eng J , vol.20 , pp. 143-148
    • Leclerc, E.1    Sakai, Y.2    Fujii, T.3
  • 85
    • 0032721936 scopus 로고    scopus 로고
    • Effect of cell-cell interactions in preservation of cellular phenotype: Cocultivation of hepatocytes and nonparenchymal cells
    • SN Bhatia UJ Balis ML Yarmush M Toner 1999 Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells FASEB J 13 1883 1900
    • (1999) FASEB J , vol.13 , pp. 1883-1900
    • Bhatia, S.N.1    Balis, U.J.2    Yarmush, M.L.3    Toner, M.4
  • 86
    • 42949114473 scopus 로고    scopus 로고
    • Recent advances in cell micropatterning techniques for bioanalytical and biomedical sciences
    • J Nakanishi T Takarada K Yamaguchi M Maeda 2008 Recent advances in cell micropatterning techniques for bioanalytical and biomedical sciences Anal Sci 24 67 72
    • (2008) Anal Sci , vol.24 , pp. 67-72
    • Nakanishi, J.1    Takarada, T.2    Yamaguchi, K.3    Maeda, M.4
  • 87
    • 38049011979 scopus 로고    scopus 로고
    • Microscale culture of human liver cells for drug development
    • SR Khetani SN Bhatia 2008 Microscale culture of human liver cells for drug development Nat Biotechnol 26 120 126
    • (2008) Nat Biotechnol , vol.26 , pp. 120-126
    • Khetani, S.R.1    Bhatia, S.N.2
  • 88
    • 0029411699 scopus 로고
    • Induction of cytochrome P-450IA1 activity in response to sublethal stresses in microcarrier-attached Hep G2 cells
    • NA Mufti ML Shuler 1995 Induction of cytochrome P-450IA1 activity in response to sublethal stresses in microcarrier-attached Hep G2 cells Biotechnol Prog 11 659 663
    • (1995) Biotechnol Prog , vol.11 , pp. 659-663
    • Mufti, N.A.1    Shuler, M.L.2
  • 89
    • 34547585202 scopus 로고    scopus 로고
    • The shear stress of it all: The cell membrane and mechanochemical transduction
    • CR White JA Frangos 2007 The shear stress of it all: the cell membrane and mechanochemical transduction Philos Trans R Soc Lond B Biol Sci 362 1459 1467
    • (2007) Philos Trans R Soc Lond B Biol Sci , vol.362 , pp. 1459-1467
    • White, C.R.1    Frangos, J.A.2
  • 91
  • 93
    • 66249113165 scopus 로고    scopus 로고
    • Connected culture of murine hepatocytes and HUVEC in a multicompartmental bioreactor
    • F Vozzi JM Heinrich A Bader AD Ahluwalia 2009 Connected culture of murine hepatocytes and HUVEC in a multicompartmental bioreactor Tissue Eng Part A 15 1291 1299
    • (2009) Tissue Eng Part A , vol.15 , pp. 1291-1299
    • Vozzi, F.1    Heinrich, J.M.2    Bader, A.3    Ahluwalia, A.D.4
  • 94
    • 65949084712 scopus 로고    scopus 로고
    • A combined pharmacokinetic-pharmacodynamic (PK-PD) model for tumor growth in the rat with UFT administration
    • JH Sung A Dhiman ML Shuler 2009 A combined pharmacokinetic- pharmacodynamic (PK-PD) model for tumor growth in the rat with UFT administration J Pharm Sci 98 1885 1904
    • (2009) J Pharm Sci , vol.98 , pp. 1885-1904
    • Sung, J.H.1    Dhiman, A.2    Shuler, M.L.3
  • 95
    • 35349029906 scopus 로고    scopus 로고
    • Real-time fluorescence detection of multiple microscale cell culture analog devices in situ
    • DOI 10.1002/cyto.a.20427
    • TI Oh JH Sung DA Tatosian ML Shuler D Kim 2007 Real-time fluorescence detection of multiple microscale cell culture analog devices in situ Cytometry A 71 857 865 (Pubitemid 47606742)
    • (2007) Cytometry Part A , vol.71 , Issue.10 , pp. 857-865
    • Oh, T.-I.1    Jong, H.S.2    Tatosian, D.A.3    Shuler, M.L.4    Kim, D.5
  • 96
    • 22144450972 scopus 로고    scopus 로고
    • Portable in situ fluorescence cytometry of microscale cell-based assays
    • DA Tatosian ML Shuler D Kim 2005 Portable in situ fluorescence cytometry of microscale cell-based assays Opt Lett 30 1689 1691
    • (2005) Opt Lett , vol.30 , pp. 1689-1691
    • Tatosian, D.A.1    Shuler, M.L.2    Kim, D.3
  • 97
    • 33845742675 scopus 로고    scopus 로고
    • An integrated fluorescence detection system for lab-on-a-chip applications
    • L Novak P Neuzil J Pipper Y Zhang S Lee 2007 An integrated fluorescence detection system for lab-on-a-chip applications Lab Chip 7 27 29
    • (2007) Lab Chip , vol.7 , pp. 27-29
    • Novak, L.1    Neuzil, P.2    Pipper, J.3    Zhang, Y.4    Lee, S.5
  • 98
    • 33847391281 scopus 로고    scopus 로고
    • A plate reader-compatible microchannel array for cell biology assays
    • H Yu CM Alexander DJ Beebe 2007 A plate reader-compatible microchannel array for cell biology assays Lab Chip 7 388 391
    • (2007) Lab Chip , vol.7 , pp. 388-391
    • Yu, H.1    Alexander, C.M.2    Beebe, D.J.3
  • 99
    • 70349306475 scopus 로고    scopus 로고
    • Fluorescence optical detection in situ for real-time monitoring of cytochrome P450 enzymatic activity of liver cells in multiple microfluidic devices
    • doi: 10.1002/bit.22413
    • Sung JH, Choi JR, Kim DH, Shuler ML (2009) Fluorescence optical detection in situ for real-time monitoring of cytochrome P450 enzymatic activity of liver cells in multiple microfluidic devices. Biotechnol Bioeng. doi: 10.1002/bit.22413
    • (2009) Biotechnol Bioeng.
    • Sung, J.H.1    Choi, J.R.2    Kim, D.H.3    Shuler, M.L.4
  • 100
    • 33745488641 scopus 로고    scopus 로고
    • Microelectronic cell sensor assay for detection of cytotoxicity and prediction of acute toxicity
    • JZ Xing L Zhu S Gabos L Xie 2006 Microelectronic cell sensor assay for detection of cytotoxicity and prediction of acute toxicity Toxicol In Vitro 20 995 1004
    • (2006) Toxicol in Vitro , vol.20 , pp. 995-1004
    • Xing, J.Z.1    Zhu, L.2    Gabos, S.3    Xie, L.4
  • 101
    • 33644772060 scopus 로고    scopus 로고
    • Microelectrode array recordings of cardiac action potentials as a high throughput method to evaluate pesticide toxicity
    • A Natarajan P Molnar K Sieverdes A Jamshidi JJ Hickman 2006 Microelectrode array recordings of cardiac action potentials as a high throughput method to evaluate pesticide toxicity Toxicol In Vitro 20 375 381
    • (2006) Toxicol in Vitro , vol.20 , pp. 375-381
    • Natarajan, A.1    Molnar, P.2    Sieverdes, K.3    Jamshidi, A.4    Hickman, J.J.5
  • 102
    • 34548028481 scopus 로고    scopus 로고
    • Cellular impedance biosensors for drug screening and toxin detection
    • F Asphahani M Zhang 2007 Cellular impedance biosensors for drug screening and toxin detection Analyst 132 835 841
    • (2007) Analyst , vol.132 , pp. 835-841
    • Asphahani, F.1    Zhang, M.2
  • 103
    • 37649010665 scopus 로고    scopus 로고
    • Microfluidics for drug discovery and development: From target selection to product lifecycle management
    • L Kang BG Chung R Langer A Khademhosseini 2008 Microfluidics for drug discovery and development: from target selection to product lifecycle management Drug Discov Today 13 1 13
    • (2008) Drug Discov Today , vol.13 , pp. 1-13
    • Kang, L.1    Chung, B.G.2    Langer, R.3    Khademhosseini, A.4
  • 104
    • 34249814614 scopus 로고    scopus 로고
    • A practical guide to microfluidic perfusion culture of adherent mammalian cells
    • L Kim YC Toh J Voldman H Yu 2007 A practical guide to microfluidic perfusion culture of adherent mammalian cells Lab Chip 7 681 694
    • (2007) Lab Chip , vol.7 , pp. 681-694
    • Kim, L.1    Toh, Y.C.2    Voldman, J.3    Yu, H.4
  • 105
    • 68149162601 scopus 로고    scopus 로고
    • Prevention of air bubble formation in a microfluidic perfusion cell culture system using a microscale bubble trap
    • doi: 10.1007/s10544-009-9286-8
    • Sung JH, Shuler ML (2009) Prevention of air bubble formation in a microfluidic perfusion cell culture system using a microscale bubble trap. Biomed Microdev. doi: 10.1007/s10544-009-9286-8
    • (2009) Biomed Microdev
    • Sung, J.H.1    Shuler, M.L.2
  • 106
    • 37349088463 scopus 로고    scopus 로고
    • Analysis of pressure-driven air bubble elimination in a microfluidic device
    • JH Kang YC Kim JK Park 2008 Analysis of pressure-driven air bubble elimination in a microfluidic device Lab Chip 8 176 178
    • (2008) Lab Chip , vol.8 , pp. 176-178
    • Kang, J.H.1    Kim, Y.C.2    Park, J.K.3
  • 107
    • 52649108807 scopus 로고    scopus 로고
    • An active bubble trap and debubbler for microfluidic systems
    • AM Skelley J Voldman 2008 An active bubble trap and debubbler for microfluidic systems Lab Chip 8 1733 1737
    • (2008) Lab Chip , vol.8 , pp. 1733-1737
    • Skelley, A.M.1    Voldman, J.2
  • 108
    • 34347256054 scopus 로고    scopus 로고
    • Microfluidic large-scale integration: The evolution of design rules for biological automation
    • J Melin SR Quake 2007 Microfluidic large-scale integration: the evolution of design rules for biological automation Annu Rev Biophys Biomol Struct 36 213 231
    • (2007) Annu Rev Biophys Biomol Struct , vol.36 , pp. 213-231
    • Melin, J.1    Quake, S.R.2
  • 109
    • 0032170726 scopus 로고    scopus 로고
    • Transport in a grooved perfusion flat-bed bioreactor for cell therapy applications
    • M Horner WM Miller JM Ottino ET Papoutsakis 1998 Transport in a grooved perfusion flat-bed bioreactor for cell therapy applications Biotechnol Prog 14 689 698
    • (1998) Biotechnol Prog , vol.14 , pp. 689-698
    • Horner, M.1    Miller, W.M.2    Ottino, J.M.3    Papoutsakis, E.T.4
  • 110
    • 21644441288 scopus 로고    scopus 로고
    • Long-term monitoring of bacteria undergoing programmed population control in a microchemostat
    • FK Balagadde L You CL Hansen FH Arnold SR Quake 2005 Long-term monitoring of bacteria undergoing programmed population control in a microchemostat Science 309 137 140
    • (2005) Science , vol.309 , pp. 137-140
    • Balagadde, F.K.1    You, L.2    Hansen, C.L.3    Arnold, F.H.4    Quake, S.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.