Patterned cardiomyocytes on microelectrode arrays as a functional, high information content drug screening platform

Biomaterials

Volumn 32, Issue 18, 2011, Pages 4267-4274

  Natarajan, Anupama ^a,b   Stancescu, Maria ^a   Dhir, Vipra ^a,c   Armstrong, Christopher ^a   Sommerhage, Frank ^a   Hickman, James J ^a,b,c   Molnar, Peter ^a,b,d  

^a UNIVERSITY OF CENTRAL FLORIDA   (United States)

^b UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

^c University of Central Florida   (United States)

^d UNIVERSITY OF WEST HUNGARY   (Hungary)

Author keywords

Biosensor; Cardiac tissue engineering; Cardiomyocyte; Electrode; In vitro test; Micropatterning

Indexed keywords

1-HEPTANOL; ACTION POTENTIAL PROPAGATION; ACTION POTENTIALS; CARDIAC MYOCYTES; CARDIAC TISSUE ENGINEERING; CARDIOMYOCYTES; CLINICAL TRIAL; CONDUCTION VELOCITY; DRUG CANDIDATES; DRUG DEVELOPMENT; DRUG SCREENING; EXTERNAL STIMULATION; GAP JUNCTIONS; HIGH-THROUGHPUT; IN-VITRO TESTS; INFORMATION CONTENTS; MICRO PATTERNING; MICROELECTRODE ARRAY; MULTIELECTRODE ARRAYS; MULTIELECTRODE RECORDINGS; REFRACTORY PERIOD; SIDE EFFECT; SPARFLOXACIN; SURFACE PATTERNING; TEMPORAL RESOLUTION;

BIOSENSORS; DRUG INTERACTIONS; ELECTROPHYSIOLOGY; MICROELECTRODES; MONOLAYERS; REFRACTORY MATERIALS; TISSUE; TISSUE ENGINEERING; VELOCITY MEASUREMENT;

HEART;

HEPTANOL; SPARFLOXACIN;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; HEART CONDUCTION; HEART FIBRILLATION; HEART MUSCLE CELL; HIGH THROUGHPUT SCREENING; MICROARRAY ANALYSIS; MICROELECTRODE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; REFRACTORY PERIOD;

ACTION POTENTIALS; ANTITUBERCULAR AGENTS; CELLS, CULTURED; CLINICAL TRIALS AS TOPIC; CULTURE MEDIA, SERUM-FREE; DRUG EVALUATION, PRECLINICAL; FLUOROQUINOLONES; HEPTANOL; HUMANS; MICROELECTRODES; MYOCYTES, CARDIAC;

EID: 79955102315     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.12.022     Document Type: Article

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