A review of mammalian toxicity of ZnO nanoparticles

Nanotechnology, Science and Applications

Volumn 5, Issue 1, 2012, Pages 61-71

  Vandebriel, Rob J ^a   De Jong, Wim H ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

Inflammation; Intracellular calcium; Lysosomes; Mitochondrial membrane potential; Reactive oxygen species; Solubility

Indexed keywords

CALCIUM ION; CXCL9 CHEMOKINE; INTERLEUKIN 8; NANOPARTICLE; NANOROD; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ZINC OXIDE NANOPARTICLE;

CALCIUM CELL LEVEL; CARCINOMA CELL; CELL CULTURE; COMET ASSAY; CYTOKINE PRODUCTION; CYTOKINESIS; CYTOTOXICITY TEST; DENDRITIC CELL; ENZYME ACTIVATION; EPITHELIUM CELL; GENOTOXICITY; HUMAN; LYMPHOCYTE; MACROPHAGE; MICRONUCLEUS TEST; MITOCHONDRIAL MEMBRANE POTENTIAL; MONOCYTE; NANOTOXICOLOGY; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PARTICLE SIZE; PROTEIN BINDING; REVIEW; SKIN CELL; ZETA POTENTIAL;

EID: 84866045532     PISSN: None     EISSN: 11778903     Source Type: Journal    
DOI: 10.2147/NSA.S23932     Document Type: Review

References (76)

1. Osmond MJ, McCall MJ. Zinc oxide nanoparticles in modern sunscreens: an analysis of potential exposure and hazard. Nanotoxicology. 2010;4(1): 15-41.
2. Witschger O, Fabriès JF. Particules ultra-fines et santé au travail:1 - Caractéristiques et effets potentiels sur la santé [Ultrafine particles and occupational health: 1 - Characteristics and potential health effects].Cahiers de notes documentaires. 2005;199:21-35. French.
3. Warheit DB, Sayes CM, Reed KL. Nanoscale and fine zinc oxide particles: can in vitro assays accurately forecast lung hazards following inhalation exposures? Environ Sci Technol. 2009;43(20):7939-7945.
4. Sayes CM, Reed KL, Warheit DB. Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles. Toxicol Sci. 2007;97(1):163-180.
5. Cho WS, Duffin R, Poland CA, et al. Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing. Environ Health Perspect. 2010;118(12): 1699-1706.
6. Cho WS, Duffin R, Poland CA, et al. Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs. Nanotoxicology. 2012;6(1):22-35.
7. Cho WS, Duffin R, Howie SE, et al. Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes. Part Fibre Toxicol. 2011;8:27.
8. Cho WS, Duffin R, Thielbeer F, et al. Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles. Toxicol Sci. 2012;126(2):469-477.
9. Xia T, Zhao Y, Sager T, et al. Decreased dissolution of ZnO by iron doping yields nanoparticles with reduced toxicity in the rodent lung and zebrafish embryos. ACS Nano. 2011;5(2):1223-1235.
10. Zhang H, Ji Z, Xia T, et al. Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation. ACS Nano. 2012;6(5):4349-4368.
11. Wang L, Wang L, Ding W, Zhang F. Acute toxicity of ferric oxide and zinc oxide nanoparticles in rats. J Nanosci Nanotechnol. 2010;10(12): 8617-8624.
12. Landsiedel R, Ma-Hock L, Kroll A, et al. Testing metal-oxide nanomaterials for human safety. Adv Mater. 2010;22(24):2601-2627.
13. Kao YY, Chen YC, Cheng TJ, Chiung YM, Liu PS. Zinc oxide nanoparticles interfere with zinc ion homeostasis to cause cytotoxicity. Toxicol Sci. 2012;125(2):462-472.
14. Ayres JG, Borm P, Cassee FR, et al. Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential - a workshop report and consensus statement. Inhal Toxicol. 2008;20(1):75-99.
15. Jachak A, Lai SK, Hida K, et al. Transport of metal oxide nanoparticles and single-walled carbon nanotubes in human mucus. Nanotoxicology. July 29, 2011. [Epub ahead of print.]
16. Cross SE, Innes B, Roberts MS, Tsuzuki T, Robertson TA, McCormick P. Human skin penetration of sunscreen nanoparticles: in-vitro assessment of a novel micronized zinc oxide formulation. Skin Pharmacol Physiol. 2007;20(3):148-154.
17. Filipe P, Silva JN, Silva R, et al. Stratum corneum is an effective barrier to TiO2 and ZnO nanoparticles percutaneous absorption. Skin Pharmacol Physiol. 2009;22(5):266-275.
18. Schilling K, Bradford B, Castelli D, et al. Human safety review of "nano" titanium dioxide and zinc oxide. Photochem Photobiol Sci. 2010;9(4):495-509.
19. Gulson B, McCall M, Korsch M, et al. Small amounts of zinc from zinc oxide particles in sunscreens applied outdoors are absorbed through human skin. Toxicol Sci. 2010;118(1):140-149.
20. Monteiro-Riviere NA, Wiench K, Landsiedel R, Schulte S, Inman AO, Riviere JE. Safety evaluation of sunscreen formulations containing titanium dioxide and zinc oxide nanoparticles in UVB sunburned skin: an in vitro and in vivo study. Toxicol Sci. 2011;123(1):264-280.
21. Surekha P, Kishore AS, Srinivas A, et al. Repeated dose dermal toxicity study of nano zinc oxide with Sprague-Dawley rats. Cutan Ocul Toxicol. 2012;31(1):26-32.
22. Newman MD, Stotland M, Ellis JI. The safety of nanosized particles in titanium dioxide- and zinc oxide-based sunscreens. J Am Acad Dermatol. 2009;61(4):685-692.
23. Han D, Tian Y, Zhang T, Ren G, Yang Z. Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocampus of Wistar rats. Int J Nanomedicine. 2011;6:1453-1461.
24. Chen JK, Shih MH, Peir JJ, et al. The use of radioactive zinc oxide nanoparticles in determination of their tissue concentrations following intravenous administration in mice. Analyst. 2010;135(7):1742-1746.
25. Li CH, Shen CC, Cheng YW, et al. Organ biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in mice. Nanotoxicology. September 27, 2011. [Epub ahead of print.]
26. Deng X, Luan Q, Chen W, et al. Nanosized zinc oxide particles induce neural stem cell apoptosis. Nanotechnology. 2009;20(11):115101.
27. Müller KH, Kulkarni J, Motskin M, et al. pH-dependent toxicity of high aspect ratio ZnO nanowires in macrophages due to intracellular dissolution. ACS Nano. 2010;4(11):6767-6779.
28. George S, Pokhrel S, Xia T, et al. Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping. ACS Nano. 2010;4(1):15-29.
29. Xia T, Kovochich M, Liong M, et al. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano. 2008;2(10):2121-2134.
30. Hsiao IL, Huang YJ. Titanium oxide shell coatings decrease the cytotoxicity of ZnO nanoparticles. Chem Res Toxicol. 2011;24(3): 303-313.
31. Huang CC, Aronstam RS, Chen DR, Huang YW. Oxidative stress, calcium homeostasis, and altered gene expression in human lung epithelial cells exposed to ZnO nanoparticles. Toxicol In Vitro. 2010;24(1): 45-55.
32. Wu W, Samet JM, Peden DB, Bromberg PA. Phosphorylation of p65 is required for zinc oxide nanoparticle-induced interleukin 8 expression in human bronchial epithelial cells. Environ Health Perspect. 2010;118(7): 982-987.
33. Ng KW, Khoo SP, Heng BC, et al. The role of the tumor suppressor p53 pathway in the cellular DNA damage response to zinc oxide nanoparticles. Biomaterials. 2011;32(32):8218-8225.
34. Hsiao IL, Huang YJ. Effects of various physicochemical characteristics on the toxicities of ZnO and TiO(2) nanoparticles toward human lung epithelial cells. Sci Total Environ. 2011;409(7):1219-1228.
35. Ahamed M, Akhtar MJ, Raja M, et al. ZnO nanorod-induced apoptosis in human alveolar adenocarcinoma cells via p53, survivin and bax/bcl-2 pathways: role of oxidative stress. Nanomedicine. 2011;7(6): 904-913.
36. Lenz AG, Karg E, Lentner B, et al. A dose-controlled system for air-liquid interface cell exposure and application to zinc oxide nanoparticles. Part Fibre Toxicol. 2009;6:32.
37. Xie Y, Williams NG, Tolic A, et al. Aerosolized ZnO nanoparticles induce toxicity in alveolar type II epithelial cells at the air-liquid interface. Toxicol Sci. 2012;125(2):450-461.
38. Kim YH, Fazlollahi F, Kennedy IM, et al. Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure. Am J Respir Crit Care Med. 2010;182(11):1398-1409.
39. Meyer K, Rajanahalli P, Ahamed M, Rowe JJ, Hong Y. ZnO nanoparticles induce apoptosis in human dermal fibroblasts via p53 and p38 pathways. Toxicol In Vitro. 2011;25(8):1721-1726.
40. Moos PJ, Olszewski K, Honeggar M, et al. Responses of human cells to ZnO nanoparticles: a gene transcription study. Metallomics. 2011;3(11): 1199-1211.
41. Kocbek P, Teskac K, Kreft ME, Kristl J. Toxicological aspects of long-term treatment of keratinocytes with ZnO and TiO2 nanoparticles. Small. 2010;6(17):1908-1917.
42. Yazdi AS, Guarda G, Riteau N, et al. Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β. Proc Natl Acad Sci U S A. 2010;107(45):19449-19454.
43. Moos PJ, Chung K, Woessner D, Honeggar M, Cutler NS, Veranth JM. ZnO particulate matter requires cell contact for toxicity in human colon cancer cells. Chem Res Toxicol. 2010;23(4):733-739.
44. de Berardis B, Civitelli G, Condello M, et al. Exposure to ZnO nanoparticles induces oxidative stress and cytotoxicity in human colon carcinoma cells. Toxicol Appl Pharmacol. 2010;246(3):116-127.
45. Hanley C, Thurber A, Hanna C, Punnoose A, Zhang J, Wingett DG. The influences of cell type and ZnO nanoparticle size on immune cell cytotoxicity and cytokine induction. Nanoscale Res Lett. 2009;4(12): 1409-1420.
46. Palomäki J, Karisola P, Pylkkänen L, Savolainen K, Alenius H. Engineered nanomaterials cause cytotoxicity and activation on mouse antigen presenting cells. Toxicology. 2010;267(1-3):125-131.
47. Song W, Zhang J, Guo J, et al. Role of the dissolved zinc ion and reactive oxygen species in cytotoxicity of ZnO nanoparticles. Toxicol Lett. 2010;199(3):389-397.
48. Buerki-Thurnherr T, Xiao L, Diener L, et al. In vitro mechanistic study towards a better understanding of ZnO nanoparticle toxicity. Nanotoxicology. March 20, 2012. [Epub ahead of print.]
49. Sun J, Wang S, Zhao D, Hun FH, Weng L, Liu H. Cytotoxicity, permeability, and inflammation of metal oxide nanoparticles in human cardiac microvascular endothelial cells: cytotoxicity, permeability, and inflammation of metal oxide nanoparticles. Cell Biol Toxicol. 2011;27(5): 333-342.
50. Yang ST, Liu JH, Wang J, et al. Cytotoxicity of zinc oxide nanoparticles: importance of microenvironment. J Nanosci Nanotechnol. 2010;10(12): 8638-8645.
51. Wang Y, Aker WG, Hwang HM, Yedjou CG, Yu H, Tchounwou PB. A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells. Sci Total Environ. 2011;409(22):4753-4762.
52. Kermanizadeh A, Pojana G, Gaiser BK, et al. In vitro assessment of engineered nanomaterials using a hepatocyte cell line: cytotoxicity, proinflammatory cytokines and functional markers. Nanotoxicology. January 20, 2012. [Epub ahead of print.]
53. Pujalté I, Passagne I, Brouillaud B, et al. Cytotoxicity and oxidative stress induced by different metallic nanoparticles on human kidney cells. Part Fibre Toxicol. 2011;8:10.
54. Yuan JH, Chen Y, Zha HX, et al. Determination, characterization and cytotoxicity on HELF cells of ZnO nanoparticles. Colloids Surf B Biointerfaces. 2010;76(1):145-150.
55. Yang H, Liu C, Yang D, Zhang H, Xi Z. Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition. J Appl Toxicol. 2009;29(1):69-78.
56. Jeng HA, Swanson J. Toxicity of metal oxide nanoparticles in mammalian cells. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2006;41(12):2699-2711.
57. Berntsen P, Park CY, Rothen-Rutishauser B, et al. Biomechanical effects of environmental and engineered particles on human airway smooth muscle cells. J R Soc Interface. 2010;7(Suppl 3):S331-S340.
58. Landsiedel R, Ma-Hock L, Van Ravenzwaay B, et al. Gene toxicity studies on titanium dioxide and zinc oxide nanomaterials used for UV-protection in cosmetic formulations. Nanotoxicology. 2010;4:364-381.
59. Pan X, Redding JE, Wiley PA, Wen L, McConnell JS, Zhang B. Mutagenicity evaluation of metal oxide nanoparticles by the bacterial reverse mutation assay. Chemosphere. 2010;79(1):113-116.
60. Yoshida R, Kitamura D, Maenosono S. Mutagenicity of water-soluble ZnO nanoparticles in Ames test. J Toxicol Sci. 2009;34(1):119-122.
61. Osman IF, Baumgartner A, Cemeli E, Fletcher JN, Anderson D. Genotoxicity and cytotoxicity of zinc oxide and titanium dioxide in HEp-2 cells. Nanomedicine (Lond). 2010;5(8):1193-1203.
62. Sharma V, Singh SK, Anderson D, Tobin DJ, Dhawan A. Zinc oxide nanoparticles induced genotoxicity in primary human epidermal keratinocytes. J Nanosci Nanotechnol. 2011;11(5):3782-3788.
63. Sharma V, Shukla RK, Saxena N, Parmar D, Das M, Dhawan A. DNA damaging potential of zinc oxide nanoparticles in human epidermal cells. Toxicol Lett. 2009;185(3):211-218.
64. Gerloff K, Albrecht C, Boots AW, Förster I, Schins RP. Cytotoxicity and oxidative DNA damage by nanoparticles in human intestinal Caco-2 cells. Nanotoxicology. 2009;3(4):355-364.
65. Hackenberg S, Zimmermann FZ, Scherzed A, et al. Repetitive exposure to zinc oxide nanoparticles induces DNA damage in human nasal mucosa mini organ cultures. Environ Mol Mutagen. 2011;52(7): 582-589.
66. Yin H, Casey PS, McCall MJ. Surface modifications of ZnO nanoparticles and their cytotoxicity. J Nanosci Nanotechnol. 2010;10(11): 7565-7570.
67. Yin H, Casey PS, McCall MJ, Fenech M. Effects of surface chemistry on cytotoxicity, genotoxicity, and the generation of reactive oxygen species induced by ZnO nanoparticles. Langmuir. 2010;26(19): 15399-15408.
68. Tso CP, Zhung CM, Shih YH, Tseng YM, Wu SC, Doong RA. Stability of metal oxide nanoparticles in aqueous solutions. Water Sci Technol. 2010;61(1):127-133.
69. Tantra R, Tompkins J, Quincey P. Characterisation of the de-agglomeration effects of bovine serum albumin on nanoparticles in aqueous suspension. Colloids Surf B Biointerfaces. 2010;75(1):275-281.
70. Deng ZJ, Mortimer G, Schiller T, Musumeci A, Martin D, Minchin RF. Differential plasma protein binding to metal oxide nanoparticles. Nanotechnology. 2009;20(45):455101.
71. Ho M, Wu KY, Chein HM, Chen LC, Cheng TJ. Pulmonary toxicity of inhaled nanoscale and fine zinc oxide particles: mass and surface area as an exposure metric. Inhal Toxicol. 2011;23(14):947-956.
72. Cosma G, Fulton H, DeFeo T, Gordon T. Rat lung metallothionein and heme oxygenase gene expression following ozone and zinc oxide exposure. Toxicol Appl Pharmacol. 1992;117(1):75-80.
73. Conner MW, Flood WH, Rogers AE, Amdur MO. Lung injury in guinea pigs caused by multiple exposures to ultrafine zinc oxide: changes in pulmonary lavage fluid. J Toxicol Environ Health. 1988;25(1):57-69.
74. Conner MW, Flood WH, Rogers AE, Amdur MO. Changes in pulmonary lavage fluid of guinea pigs exposed to ultrafine zinc oxide with adsorbed sulfuric acid. J Toxicol Environ Health. 1989;26(2):223-234.
75. Lam HF, Conner MW, Rogers AE, Fitzgerald S, Amdur MO. Functional and morphologic changes in the lungs of guinea pigs exposed to freshly generated ultrafine zinc oxide. Toxicol Appl Pharmacol. 1985;78(1): 29-38.
76. Fine JM, Gordon T, Chen LC, Kinney P, Falcone G, Beckett WS. Metal fume fever: characterization of clinical and plasma IL-6 responses in controlled human exposures to zinc oxide fume at and below the threshold limit value. J Occup Environ Med. 1997;39(8): 722-726.