Engineering a scaffold-free 3D tumor model for in vitro drug penetration studies

Biomaterials

Volumn 31, Issue 6, 2010, Pages 1180-1190

  Ong, Siew Min ^a,b,c   Zhao, Ziqing ^a   Arooz, Talha ^a   Zhao, Deqiang ^a,d   Zhang, Shufang ^a,e   Du, Tiehua ^f   Wasser, Martin ^f   van Noort, Danny ^a,d   Yu, Hanry ^a,b,d,g,h,i  

^a INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c AGENCY FOR SCIENCE   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^f BIOINFORMATICS INSTITUTE   (Singapore)

^g NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^h SINGAPORE MIT ALLIANCE   (Singapore)

ⁱ Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Drug penetration; Liver; Solid tumour model; Spheroid; Synthetic inter cellular linker

Indexed keywords

CANCER MODELS; CANCER RESEARCH; CELL-CELL INTERACTION; CELLULAR FUNCTION; DOSE-DEPENDENT; DRUG PENETRATION; EXTRACELLULAR ACCUMULATIONS; EXTRACELLULAR MATRICES; GENE EXPRESSION PROFILES; HEPATOCELLULAR CARCINOMA CELL; IN-VITRO; IN-VIVO; MICROENVIRONMENTS; OXYGEN CONCENTRATION GRADIENTS; THREE-DIMENSIONAL (3D); TUMOR MODELS; TUMOR SPHEROID;

CELL CULTURE; DRUG DOSAGE; ENZYME ACTIVITY; GENE EXPRESSION; LIVER; OXYGEN; TUMORS;

THREE DIMENSIONAL;

DOXORUBICIN; OXYGEN;

ARTICLE; BIOENGINEERING; BIOLOGICAL MODEL; CANCER RESEARCH; CELL FUNCTION; CELL GROWTH; CELL INTERACTION; CELL PROLIFERATION; CELL SIZE; CELL STRUCTURE; CONTROLLED STUDY; CULTURE TECHNIQUE; DRUG PENETRATION; EXTRACELLULAR MATRIX; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; MULTICELLULAR SPHEROID; PRIORITY JOURNAL; TUMOR SPHEROID;

BIOLOGICAL ASSAY; CARCINOMA, HEPATOCELLULAR; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; DOXORUBICIN; DRUG EVALUATION, PRECLINICAL; HUMANS; PHARMACOKINETICS; SPHEROIDS, CELLULAR; TISSUE ENGINEERING;

EID: 72449142109     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.10.049     Document Type: Article

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