-
1
-
-
0037374498
-
The price of innovation: new estimates of drug development costs
-
DiMasi J.A., Hansen R.W., Grabowski H.G. The price of innovation: new estimates of drug development costs. J. Health Econ. 2003, 22:151-185.
-
(2003)
J. Health Econ.
, vol.22
, pp. 151-185
-
-
DiMasi, J.A.1
Hansen, R.W.2
Grabowski, H.G.3
-
2
-
-
44349108396
-
Shedding light on an old mystery: thalidomide suppresses survival pathways to induce limb defects
-
Knobloch J., Ruther U. Shedding light on an old mystery: thalidomide suppresses survival pathways to induce limb defects. Cell Cycle 2008, 7:1121-1127.
-
(2008)
Cell Cycle
, vol.7
, pp. 1121-1127
-
-
Knobloch, J.1
Ruther, U.2
-
3
-
-
64549117445
-
Monolayer and spheroid culture of human liver hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes
-
Chang T.T., Hughes-Fulford M. Monolayer and spheroid culture of human liver hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes. Tissue Eng. Part A 2009, 15:559-567.
-
(2009)
Tissue Eng. Part A
, vol.15
, pp. 559-567
-
-
Chang, T.T.1
Hughes-Fulford, M.2
-
4
-
-
77953916745
-
Multicellular tumor spheroids: an underestimated tool is catching up again
-
Hirschhaeuser F., Menne H., Dittfeld C., West J., Mueller-Klieser W., Kunz-Schughart L.A. Multicellular tumor spheroids: an underestimated tool is catching up again. J. Biotechnol. 2010, 148:3-15.
-
(2010)
J. Biotechnol.
, vol.148
, pp. 3-15
-
-
Hirschhaeuser, F.1
Menne, H.2
Dittfeld, C.3
West, J.4
Mueller-Klieser, W.5
Kunz-Schughart, L.A.6
-
5
-
-
84862181007
-
Organotypic liver culture models: meeting current challenges in toxicity testing
-
Lecluyse E.L., Witek R.P., Andersen M.E., Powers M.J. Organotypic liver culture models: meeting current challenges in toxicity testing. Crit. Rev. Toxicol. 2012, 42:501-548.
-
(2012)
Crit. Rev. Toxicol.
, vol.42
, pp. 501-548
-
-
Lecluyse, E.L.1
Witek, R.P.2
Andersen, M.E.3
Powers, M.J.4
-
6
-
-
68549104172
-
Three-dimensional tissue models for drug discovery and toxicology
-
Pampaloni F., Stelzer E.H., Masotti A. Three-dimensional tissue models for drug discovery and toxicology. Recent Pat. Biotechnol. 2009, 3:103-117.
-
(2009)
Recent Pat. Biotechnol.
, vol.3
, pp. 103-117
-
-
Pampaloni, F.1
Stelzer, E.H.2
Masotti, A.3
-
7
-
-
15944404223
-
TGF-beta1 regulation in hepatocyte-NIH3T3 co-culture is important for the enhanced hepatocyte function in 3D microenvironment
-
Chia S.M., Lin P.C., Yu H. TGF-beta1 regulation in hepatocyte-NIH3T3 co-culture is important for the enhanced hepatocyte function in 3D microenvironment. Biotechnol. Bioeng. 2005, 89:565-573.
-
(2005)
Biotechnol. Bioeng.
, vol.89
, pp. 565-573
-
-
Chia, S.M.1
Lin, P.C.2
Yu, H.3
-
8
-
-
61949475114
-
Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function
-
Brophy C.M., Luebke-Wheeler J.L., Amiot B.P., Khan H., Remmel R.P., Rinaldo P., Nyberg S.L. Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function. Hepatology 2009, 49:578-586.
-
(2009)
Hepatology
, vol.49
, pp. 578-586
-
-
Brophy, C.M.1
Luebke-Wheeler, J.L.2
Amiot, B.P.3
Khan, H.4
Remmel, R.P.5
Rinaldo, P.6
Nyberg, S.L.7
-
9
-
-
38849113971
-
Formation and characterization of three dimensional human hepatocyte cell line spheroids on chitosan matrix for in vitro tissue engineering applications
-
Verma P., Verma V., Ray P., Ray A.R. Formation and characterization of three dimensional human hepatocyte cell line spheroids on chitosan matrix for in vitro tissue engineering applications. In Vitro Cell. Dev. Biol. Anim. 2007, 43:328-337.
-
(2007)
In Vitro Cell. Dev. Biol. Anim.
, vol.43
, pp. 328-337
-
-
Verma, P.1
Verma, V.2
Ray, P.3
Ray, A.R.4
-
10
-
-
0033800091
-
Multicellular resistance: a paradigm for clinical resistance?
-
Desoize B., Jardillier J. Multicellular resistance: a paradigm for clinical resistance?. Crit. Rev. Oncol. Hematol. 2000, 36:193-207.
-
(2000)
Crit. Rev. Oncol. Hematol.
, vol.36
, pp. 193-207
-
-
Desoize, B.1
Jardillier, J.2
-
11
-
-
33745933652
-
A method for the effective formation of hepatocyte spheroids using a biodegradable polymer nanosphere
-
Gwak S.J., Choi D., Paik S.S., Cho S.W., Kim S.S., Choi C.Y., Kim B.S. A method for the effective formation of hepatocyte spheroids using a biodegradable polymer nanosphere. J. Biomed. Mater. Res., A 2006, 78:268-275.
-
(2006)
J. Biomed. Mater. Res., A
, vol.78
, pp. 268-275
-
-
Gwak, S.J.1
Choi, D.2
Paik, S.S.3
Cho, S.W.4
Kim, S.S.5
Choi, C.Y.6
Kim, B.S.7
-
12
-
-
4544323430
-
Influence of pancreatic islets on spheroid formation and functions of hepatocytes in hepatocyte-pancreatic islet spheroid culture
-
Lee K.W., Lee S.K., Joh J.W., Kim S.J., Lee B.B., Kim K.W., Lee K.U. Influence of pancreatic islets on spheroid formation and functions of hepatocytes in hepatocyte-pancreatic islet spheroid culture. Tissue Eng. 2004, 10:965-977.
-
(2004)
Tissue Eng.
, vol.10
, pp. 965-977
-
-
Lee, K.W.1
Lee, S.K.2
Joh, J.W.3
Kim, S.J.4
Lee, B.B.5
Kim, K.W.6
Lee, K.U.7
-
13
-
-
36849009670
-
Experimental anti-tumor therapy in 3-D: spheroids-old hat or new challenge?
-
Friedrich J., Ebner R., Kunz-Schughart L.A. Experimental anti-tumor therapy in 3-D: spheroids-old hat or new challenge?. Int. J. Radiat. Biol. 2007, 83:849-871.
-
(2007)
Int. J. Radiat. Biol.
, vol.83
, pp. 849-871
-
-
Friedrich, J.1
Ebner, R.2
Kunz-Schughart, L.A.3
-
14
-
-
79959881706
-
Establishment of self-organization system in rapidly formed multicellular heterospheroids
-
Kojima N., Takeuchi S., Sakai Y. Establishment of self-organization system in rapidly formed multicellular heterospheroids. Biomaterials 2011, 32:6059-6067.
-
(2011)
Biomaterials
, vol.32
, pp. 6059-6067
-
-
Kojima, N.1
Takeuchi, S.2
Sakai, Y.3
-
15
-
-
33645885899
-
Hepatocyte spheroid formation on a titanium dioxide gel surface and hepatocyte long-term culture
-
Nakazawa K., Lee S.W., Fukuda J., Yang D.H., Kunitake T. Hepatocyte spheroid formation on a titanium dioxide gel surface and hepatocyte long-term culture. J. Mater. Sci. - Mater. Med. 2006, 17:359-364.
-
(2006)
J. Mater. Sci. - Mater. Med.
, vol.17
, pp. 359-364
-
-
Nakazawa, K.1
Lee, S.W.2
Fukuda, J.3
Yang, D.H.4
Kunitake, T.5
-
16
-
-
80052351691
-
Concave microwell based size-controllable hepatosphere as a three-dimensional liver tissue model
-
S.F. Wong, Y. No da, Y.Y. Choi, D.S. Kim, B.G. Chung, S.H. Lee, Concave microwell based size-controllable hepatosphere as a three-dimensional liver tissue model, Biomaterials 32 (2011), 8087-8096.
-
(2011)
Biomaterials
, vol.32
, pp. 8087-8096
-
-
Wong, S.F.1
No Da, Y.2
Choi, Y.Y.3
Kim, D.S.4
Chung, B.G.5
Lee, S.H.6
-
17
-
-
79952038728
-
The tumor microenvironment in hepatocellular carcinoma: current status and therapeutic targets
-
Yang J.D., Nakamura I., Roberts L.R. The tumor microenvironment in hepatocellular carcinoma: current status and therapeutic targets. Semin. Cancer Biol. 2011, 21:35-43.
-
(2011)
Semin. Cancer Biol.
, vol.21
, pp. 35-43
-
-
Yang, J.D.1
Nakamura, I.2
Roberts, L.R.3
-
18
-
-
34547690632
-
Hypoxia and hepatocellular carcinoma: the therapeutic target for hepatocellular carcinoma
-
Wu X.Z., Xie G.R., Chen D. Hypoxia and hepatocellular carcinoma: the therapeutic target for hepatocellular carcinoma. J. Gastroenterol. Hepatol. 2007, 22:1178-1182.
-
(2007)
J. Gastroenterol. Hepatol.
, vol.22
, pp. 1178-1182
-
-
Wu, X.Z.1
Xie, G.R.2
Chen, D.3
-
19
-
-
51649120660
-
A new technique for primary hepatocyte expansion in vitro
-
Cho C.H., Berthiaume F., Tilles A.W., Yarmush M.L. A new technique for primary hepatocyte expansion in vitro. Biotechnol. Bioeng. 2008, 101:345-356.
-
(2008)
Biotechnol. Bioeng.
, vol.101
, pp. 345-356
-
-
Cho, C.H.1
Berthiaume, F.2
Tilles, A.W.3
Yarmush, M.L.4
-
20
-
-
79953736762
-
Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells
-
Schrader J., Gordon-Walker T.T., Aucott R.L., van Deemter M., Quaas A., Walsh S., Benten D., Forbes S.J., Wells R.G., Iredale J.P. Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells. Hepatology 2011, 53:1192-1205.
-
(2011)
Hepatology
, vol.53
, pp. 1192-1205
-
-
Schrader, J.1
Gordon-Walker, T.T.2
Aucott, R.L.3
van Deemter, M.4
Quaas, A.5
Walsh, S.6
Benten, D.7
Forbes, S.J.8
Wells, R.G.9
Iredale, J.P.10
-
21
-
-
47149085610
-
Solid tumor physiology and hypoxia-induced chemo/radio-resistance. novel strategy for cancer therapy: nitric oxide donor as a therapeutic enhancer
-
Yasuda H. Solid tumor physiology and hypoxia-induced chemo/radio-resistance. novel strategy for cancer therapy: nitric oxide donor as a therapeutic enhancer. Nitric Oxide 2008, 19:205-216.
-
(2008)
Nitric Oxide
, vol.19
, pp. 205-216
-
-
Yasuda, H.1
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