Cardiac tissue slices with prolonged survival for in vitro drug safety screening

Journal of Pharmacological and Toxicological Methods

Volumn 66, Issue 2, 2012, Pages 145-151

  Bussek, Alexandra ^a,b   Schmidt, Matthias ^a   Bauriedl, Jessica ^a   Ravens, Ursula ^b   Wettwer, Erich ^b   Lohmann, Horst ^a  

^a Lohmann Research Equipment   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Action potential; Cardiac; Field potential; Guinea pig; In vitro methods; Rat

Indexed keywords

4 AMINOPYRIDINE; CARBENOXOLONE; NIFEDIPINE; POTASSIUM CHANNEL BLOCKING AGENT;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; DRUG MECHANISM; DRUG SAFETY; DRUG SCREENING; ELECTRIC POTENTIAL; ELECTROSTIMULATION; GAP JUNCTION; GUINEA PIG; HEART; HEART VENTRICLE; IN VITRO STUDY; MALE; NONHUMAN; RAT; RISK ASSESSMENT; SURVIVAL;

4-AMINOPYRIDINE; ACTION POTENTIALS; ANIMAL TESTING ALTERNATIVES; ANIMALS; ANIMALS, LABORATORY; ANTI-ARRHYTHMIA AGENTS; CALCIUM CHANNEL BLOCKERS; CARBENOXOLONE; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; GUINEA PIGS; HEART VENTRICLES; MALE; NIFEDIPINE; PHARMACEUTICAL PREPARATIONS; PIPERIDINES; POTASSIUM CHANNEL BLOCKERS; PYRIDINES; RATS; RATS, WISTAR; RISK ASSESSMENT; TOXICITY TESTS;

CAVIA; MAMMALIA; RATTUS;

EID: 84865653847     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2011.12.002     Document Type: Article

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