Engineering tumors with 3D scaffolds

Nature Methods

Volumn 4, Issue 10, 2007, Pages 855-860

  Fischbach, Claudia ^a,b   Chen, Ruth ^a   Matsumoto, Takuya ^c   Schmelzle, Tobias ^d   Brugge, Joan S ^d   Polverini, Peter J ^e   Mooney, David J ^a  

^a HARVARD UNIVERSITY   (United States)

^b Cornell University   (United States)

^c OSAKA UNIVERSITY   (Japan)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; MATRIGEL; POLYMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOMIMETICS; CANCER RESISTANCE; CARCINOMA CELL; CONTROLLED STUDY; DRUG RESPONSE; DRUG SENSITIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; LEWIS CARCINOMA; MALE; MOUSE; MOUTH CARCINOMA; NONHUMAN; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TISSUE ENGINEERING; TUMOR CELL; TUMOR CELL CULTURE; TUMOR CELL LINE; TUMOR MODEL; TUMOR VASCULARIZATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, SQUAMOUS CELL; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG EVALUATION, PRECLINICAL; HUMANS; MALE; MICE; MOUTH NEOPLASMS; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; TISSUE ENGINEERING;

EID: 35848959463     PISSN: 15487091     EISSN: 15491676     Source Type: Journal    
DOI: 10.1038/nmeth1085     Document Type: Article

References (30)

1. Bissell, M.J. & Radisky, D. Putting tumours in context. Nat Rev. Cancer 1, 46-54 (2001).
2. Hanahan, D. & Weinberg, R.A. The hallmarks of cancer. Cell 100 57-70 (2000).
3. Harris, A.L. Hypoxia-a key regulatory factor in tumour growth. Nat. Rev. Cancer 2, 38-47 (2002).
4. Debnath, J. & Brugge, J.S. Modelling glandular epithelial cancers in three-dimensional cultures. Nat. Rev. Cancer 5, 675-688 (2005).
5. Sutherland, R.M. et al. Oxygenation and differentiation in multicellular spheroids of human colon carcinoma. Cancer Res. 46, 5320-5329 (1986).
6. Debnath, J., Muthuswamy, S.K. & Brugge, J.S. Morphogenesis aud oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 30, 256-268 (2003).
7. Lee, G.Y., Kenny, P.A., Lee, E.H & Bissell, M.J. Three-dimensional culture models of normal and malignant breast epithelial cells. Nat. Methods 4, 359-365 (2007).
8. Adam, M.F., Dorie, M.J. & Brown, J.M. Oxygen tension measurements of tumors growing in mice. Int. J. Radiat. Oncol. Biol. Phys. 45 171-180 (1999).
9. Zahir, N. et al. Autocrine laminin-5 ligates {alpha}6{beta}4 integrin and activates RAC and NF{kappa}B to mediate anchorage-independent survival of mammary tumors. J. Cell Biol. 163, 1397-1407 (2003).
10. Yuen, H.W. et al. Suppression of laminin-5 expression leads to increased motility, tumorigenicity, and invasion. Exp. Cell Res. 309, 198-210 (2005).
11. Sethi, T. et al. Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo. Nat. Med. 5, 662-668 (1999).
12. Zhang, Y., Lu, H., Dazin, P. & Kapila, Y. Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: Fibronectin and integrin {alpha}v mediate survival signals through focal adhesion kinase. J. Biol. Chem. 279; 48342-48349 (2004).
13. Kerbel, R. & Folkman, J. Clinical translation of angiogenesis inhibitors. Nat. Rev. Cancer 2, 727-739 (2002).
14. Le, Y.J. & Corry, P.M. Hypoxia-induced bFGF gene expression is mediated through the JNK signal transduction pathway. Mol. Cell. Biochem. 202, 1-8 (1999).
15. Xie, K. Interleukin-8 and human cancer biology. Cytokine Growth Factor Rev. 12, 375-391 (2001).
16. Mizukami, Y. et al. Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells. Nat. Med. 11, 992-997 (2005).
17. Li, A. et al. Autocrine role of interleukin-8 in induction of endothelial cell proliferation, survival, migration and MMP-2 production and angiogenesis. Angiogenesis 8, 63-71 (2005).
18. Christofori, G. New signals from the invasive front. Nature 441 444-450 (2006).
19. Mueller, M.M. & Fusenig, N.E. Friends or foes - bipolar effects of the tumour stroma in cancer. Nat. Rev. Cancer 4, 839-849 (2004).
20. Janes, S.M. & Watt, F.M. New roles for integrins in squamous-cell carcinoma. Nat. Rev. Cancer 6, 175-183 (2006).
21. Maschler, S. et al. Tumor cell invasiveness correlates with changes in integrin expression and localization. Oncogene 24 2032-2041 (2005).
22. Qian, F., Zhang, Z.C., Wu, A.F., Li, Y.P. & Xu, Q. Interaction between integrin [alpha]5 and fibronectin is required for metastasis of B16F10 melanoma cells. Biochem. Biophys. Res. Commun. 333, 1269-1275 (2005).
23. Islam, S., Carey, T.E., Wolf, G.T., Wheelock, M.J. Johnson, K.R. Expression of N-cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell-cell adhesion. J. Cell Biol. 135, 1643-1654 (1996).
24. Desmouliere, A., Guyot, C. & Gabbiani, G. The stroma reaction myofibroblast: A key player in the control of tumor cell behavior. Int. J. Dev. Biol. 48, 509-517 (2004).
25. dit Faute, M.A. et al. Distinctive alterations of invasiveness, drug esistance and cell-cell organization in 3D-cultures of MCF-7, a human breast cancer cell line, and its multidrug resistant variant. Clin. Exp. Metastasis 19, 161-168 (2002).
26. Kumar, P. et al. Combination treatment significantly enhances the efficacy of antitumor therapy by preferentially targeting angiogenesis. Lab. Invest. 85, 756-767 (2005).
27. Ferrara, N., Hillan, K.J. & Novotny, W. Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy. Biochem. Biophys. Res. Commun. 333, 328-335 (2005).
28. Alsberg, E., Anderson, K.W., Albeiruti, A., Rowley, J.A. & Mooney, D.J. Engineering growing tissues. Proc. Natl. Acad. Sci. USA 99, 12025-12030 (2002).
29. Richardson, T.P., Peters, M.C., Ennett, A.B. & Mooney, D.J. Polymeric system for dual growth factor delivery. Nat. Biotechnol. 19, 1029-1034 (2001).
30. Harris, L.D., Kim, B.S. & Mooney, D.J. Open pore biodegradable matrices formed with gas foaming. J. Biomed. Mater. Res. 42, 396-402 (1998).