메뉴 건너뛰기




Volumn 28, Issue 3, 2007, Pages 559-566

A multicellular spheroid array to realize spheroid formation, culture, and viability assay on a chip

Author keywords

Biosensor; Cytotoxicity; Electrochemistry; Microfluidic device; Polydimethylsiloxane; Spheroids

Indexed keywords

CELL SUSPENSION; CYTOTOXICITY; MICROFLUIDIC DEVICE; POLYDIMETHYLSILOXANE; SPHEROIDS;

EID: 33750156301     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2006.08.054     Document Type: Article
Times cited : (155)

References (44)
  • 1
    • 0037357723 scopus 로고    scopus 로고
    • Integration of cell culture and microfabrication technology
    • Park T.H., and Shuler M.L. Integration of cell culture and microfabrication technology. Biotechnol Prog 19 (2003) 243-253
    • (2003) Biotechnol Prog , vol.19 , pp. 243-253
    • Park, T.H.1    Shuler, M.L.2
  • 2
    • 2142702936 scopus 로고    scopus 로고
    • Biology on a chip: microfabrication for studying the behavior of cultured cells
    • Li N., Tourovskaia A., and Folch A. Biology on a chip: microfabrication for studying the behavior of cultured cells. Crit Rev Biomed Eng 31 (2003) 423-488
    • (2003) Crit Rev Biomed Eng , vol.31 , pp. 423-488
    • Li, N.1    Tourovskaia, A.2    Folch, A.3
  • 3
    • 23944523469 scopus 로고    scopus 로고
    • Microengineering the environment of mammalian cells in culture
    • Chen C.S., Jiang X., and Whitesides G.M. Microengineering the environment of mammalian cells in culture. MRS Bull 30 (2005) 194-201
    • (2005) MRS Bull , vol.30 , pp. 194-201
    • Chen, C.S.1    Jiang, X.2    Whitesides, G.M.3
  • 4
    • 23844499837 scopus 로고    scopus 로고
    • Microfluidics for flow cytometric analysis of cells and particles
    • Huh D., Gu W., Kamotani Y., Grotberg J.B., and Takayama S. Microfluidics for flow cytometric analysis of cells and particles. Physiol Meas 26 (2005) R73-R98
    • (2005) Physiol Meas , vol.26
    • Huh, D.1    Gu, W.2    Kamotani, Y.3    Grotberg, J.B.4    Takayama, S.5
  • 6
    • 12144263348 scopus 로고    scopus 로고
    • Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays
    • Hung P.J., Lee P.J., Sabounchi P., Lin R., and Lee L.P. Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays. Biotechnol Bioeng 89 (2005) 1-8
    • (2005) Biotechnol Bioeng , vol.89 , pp. 1-8
    • Hung, P.J.1    Lee, P.J.2    Sabounchi, P.3    Lin, R.4    Lee, L.P.5
  • 7
    • 28944445545 scopus 로고    scopus 로고
    • Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays
    • Khademhosseini A., Yeh J., Eng G., Karp J., Kaji H., Borenstein J., et al. Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays. Lab Chip 5 (2005) 1380-1386
    • (2005) Lab Chip , vol.5 , pp. 1380-1386
    • Khademhosseini, A.1    Yeh, J.2    Eng, G.3    Karp, J.4    Kaji, H.5    Borenstein, J.6
  • 9
    • 1942437993 scopus 로고    scopus 로고
    • Microenvironment design considerations for cellular scale studies
    • Walker G.M., Zeringue H.C., and Beebe D.J. Microenvironment design considerations for cellular scale studies. Lab Chip 4 (2004) 91-97
    • (2004) Lab Chip , vol.4 , pp. 91-97
    • Walker, G.M.1    Zeringue, H.C.2    Beebe, D.J.3
  • 11
    • 0346710425 scopus 로고    scopus 로고
    • Localized chemical stimulation to micropatterned cells using multiple laminar fluid flows
    • Kaji H., Nishizawa M., and Matsue T. Localized chemical stimulation to micropatterned cells using multiple laminar fluid flows. Lab Chip 3 (2003) 208-211
    • (2003) Lab Chip , vol.3 , pp. 208-211
    • Kaji, H.1    Nishizawa, M.2    Matsue, T.3
  • 12
    • 1842814047 scopus 로고    scopus 로고
    • Incorporation of 3T3-L1 cells to mimic bioaccumulation in a microscale cell culture analog device for toxicity studies
    • Viravaidya K., and Shuler M.L. Incorporation of 3T3-L1 cells to mimic bioaccumulation in a microscale cell culture analog device for toxicity studies. Biotechnol Prog 20 (2004) 590-597
    • (2004) Biotechnol Prog , vol.20 , pp. 590-597
    • Viravaidya, K.1    Shuler, M.L.2
  • 13
    • 12344282703 scopus 로고    scopus 로고
    • Differentiation-on-a-chip: a microfluidic platform for long-term cell culture studies
    • Tourovskaia A., Figueroa-Masot X., and Folch A. Differentiation-on-a-chip: a microfluidic platform for long-term cell culture studies. Lab Chip 5 (2005) 14-19
    • (2005) Lab Chip , vol.5 , pp. 14-19
    • Tourovskaia, A.1    Figueroa-Masot, X.2    Folch, A.3
  • 14
    • 14844320510 scopus 로고    scopus 로고
    • In vitro zonation and toxicity in a hepatocyte bioreactor
    • Allen J.W., Khetani S.R., and Bhatia S.N. In vitro zonation and toxicity in a hepatocyte bioreactor. Toxicol Sci 84 (2005) 110-119
    • (2005) Toxicol Sci , vol.84 , pp. 110-119
    • Allen, J.W.1    Khetani, S.R.2    Bhatia, S.N.3
  • 15
    • 21644489338 scopus 로고    scopus 로고
    • Computer-controlled microcirculatory support system for endothelial cell culture and shearing
    • Song J.W., Gu W., Futai N., Warner K.A., Nor J.E., and Takayama S. Computer-controlled microcirculatory support system for endothelial cell culture and shearing. Anal Chem 77 (2005) 3993-3999
    • (2005) Anal Chem , vol.77 , pp. 3993-3999
    • Song, J.W.1    Gu, W.2    Futai, N.3    Warner, K.A.4    Nor, J.E.5    Takayama, S.6
  • 16
    • 0036774181 scopus 로고    scopus 로고
    • Cell interactions with three-dimensional matrices
    • Cukierman E., Pankov R., and Yamada K.M. Cell interactions with three-dimensional matrices. Curr Opin Cell Biol 14 (2002) 633-639
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 633-639
    • Cukierman, E.1    Pankov, R.2    Yamada, K.M.3
  • 17
    • 0042358985 scopus 로고    scopus 로고
    • Biology's new dimension
    • Abotto A. Biology's new dimension. Nature 427 (2003) 870-872
    • (2003) Nature , vol.427 , pp. 870-872
    • Abotto, A.1
  • 18
    • 12344318372 scopus 로고    scopus 로고
    • Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?
    • Bissell M.J., and LaBarge M.A. Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?. Cancer Cell 7 (2005) 17-23
    • (2005) Cancer Cell , vol.7 , pp. 17-23
    • Bissell, M.J.1    LaBarge, M.A.2
  • 20
    • 16544380146 scopus 로고    scopus 로고
    • The use of 3-D cultures for high-throughput screening: the multicellular spheroid model
    • Kunz-Schughart L.A., Freyer J.P., Hofstaedter F., and Ebner R. The use of 3-D cultures for high-throughput screening: the multicellular spheroid model. J Biomol Screen 9 (2004) 273-285
    • (2004) J Biomol Screen , vol.9 , pp. 273-285
    • Kunz-Schughart, L.A.1    Freyer, J.P.2    Hofstaedter, F.3    Ebner, R.4
  • 21
    • 0024281372 scopus 로고
    • Cell and environment interactions in tumor microregions: the multicell spheroid model
    • Sutherland R.M. Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 240 (1988) 177-184
    • (1988) Science , vol.240 , pp. 177-184
    • Sutherland, R.M.1
  • 22
    • 0030697292 scopus 로고    scopus 로고
    • Three-dimensional cell cultures: from molecular mechanisms to clinical applications
    • Mueller-Klieser W. Three-dimensional cell cultures: from molecular mechanisms to clinical applications. Am J Physiol 273 (1997) C1109-C1123
    • (1997) Am J Physiol , vol.273
    • Mueller-Klieser, W.1
  • 23
    • 0030588693 scopus 로고    scopus 로고
    • Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes
    • LeCluyse E.L., Bullock P.L., and Parkinson A. Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes. Adv Drug Deliv Rev 33 (1996) 133-186
    • (1996) Adv Drug Deliv Rev , vol.33 , pp. 133-186
    • LeCluyse, E.L.1    Bullock, P.L.2    Parkinson, A.3
  • 24
    • 0025135443 scopus 로고
    • Formation of multicellular spheroids composed of adult rat hepatocytes in dishes with positively charged surfaces and under other nonadherent environments
    • Koide N., Sakaguchi K., Koide Y., Asano K., Kawaguchi M., Matsushima H., et al. Formation of multicellular spheroids composed of adult rat hepatocytes in dishes with positively charged surfaces and under other nonadherent environments. Exp Cell Res 186 (1990) 227-235
    • (1990) Exp Cell Res , vol.186 , pp. 227-235
    • Koide, N.1    Sakaguchi, K.2    Koide, Y.3    Asano, K.4    Kawaguchi, M.5    Matsushima, H.6
  • 25
    • 4544379388 scopus 로고    scopus 로고
    • Two-dimensional multiarray formation of hepatocyte spheroids on a microfabricated PEG-brush surface
    • Otsuka H., Hirano A., Nagasaki Y., Okano T., Horiike Y., and Kataoka K. Two-dimensional multiarray formation of hepatocyte spheroids on a microfabricated PEG-brush surface. ChemBioChem 5 (2004) 850-855
    • (2004) ChemBioChem , vol.5 , pp. 850-855
    • Otsuka, H.1    Hirano, A.2    Nagasaki, Y.3    Okano, T.4    Horiike, Y.5    Kataoka, K.6
  • 26
    • 27644455685 scopus 로고    scopus 로고
    • Novel hepatocyte culture system developed using microfabrication and collagen/polyethylene glycol microcontact printing
    • Fukuda J., Sakai Y., and Nakazawa K. Novel hepatocyte culture system developed using microfabrication and collagen/polyethylene glycol microcontact printing. Biomaterials 27 (2006) 1061-1070
    • (2006) Biomaterials , vol.27 , pp. 1061-1070
    • Fukuda, J.1    Sakai, Y.2    Nakazawa, K.3
  • 28
    • 2942709867 scopus 로고    scopus 로고
    • Microfluidic PDMS (polydimethylsiloxane) bioreactor for large-scale culture of hepatocytes
    • Leclerc E., Sakai Y., and Fujii T. Microfluidic PDMS (polydimethylsiloxane) bioreactor for large-scale culture of hepatocytes. Biotechnol Prog 20 (2004) 750-755
    • (2004) Biotechnol Prog , vol.20 , pp. 750-755
    • Leclerc, E.1    Sakai, Y.2    Fujii, T.3
  • 29
    • 19944364211 scopus 로고    scopus 로고
    • Three-dimensional micro-culture system with a silicon-based cell array device for multi-channel drug sensitivity test
    • Shiku H., Torisawa Y., Takagi A., Aoyagi S., Abe H., Hoshi H., et al. Three-dimensional micro-culture system with a silicon-based cell array device for multi-channel drug sensitivity test. Sensor Actuator B 108 (2005) 597-602
    • (2005) Sensor Actuator B , vol.108 , pp. 597-602
    • Shiku, H.1    Torisawa, Y.2    Takagi, A.3    Aoyagi, S.4    Abe, H.5    Hoshi, H.6
  • 30
    • 24744455287 scopus 로고    scopus 로고
    • A multicellular spheroid-based drug sensitivity test by scanning electrochemical microscopy
    • Torisawa Y., Takagi A., Shiku H., Yasukawa T., and Matsue T. A multicellular spheroid-based drug sensitivity test by scanning electrochemical microscopy. Oncol Rep 13 (2005) 1107-1112
    • (2005) Oncol Rep , vol.13 , pp. 1107-1112
    • Torisawa, Y.1    Takagi, A.2    Shiku, H.3    Yasukawa, T.4    Matsue, T.5
  • 32
    • 0034730139 scopus 로고    scopus 로고
    • Scanning electrochemical microscopy of living cells: different redox activities of nonmetastatic and metastatic human breast cells
    • Liu B., Rotenberg S.A., and Mirkin M.V. Scanning electrochemical microscopy of living cells: different redox activities of nonmetastatic and metastatic human breast cells. Proc Natl Acad Sci USA 97 (2000) 9855-9860
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 9855-9860
    • Liu, B.1    Rotenberg, S.A.2    Mirkin, M.V.3
  • 33
    • 0033673083 scopus 로고    scopus 로고
    • Characterization and imaging of single cells with scanning electrochemical microscopy
    • Yasukawa T., Kaya T., and Matsue T. Characterization and imaging of single cells with scanning electrochemical microscopy. Electroanalysis 12 (2000) 653-659
    • (2000) Electroanalysis , vol.12 , pp. 653-659
    • Yasukawa, T.1    Kaya, T.2    Matsue, T.3
  • 34
    • 11144243646 scopus 로고    scopus 로고
    • Menadione metabolism to thiodione in hepatoblastoma by scanning electrochemical microscopy
    • Mauzeroll J., Bard A.J., Owhadian O., and Monks T.J. Menadione metabolism to thiodione in hepatoblastoma by scanning electrochemical microscopy. Proc Natl Acad Sci USA 101 (2004) 17582-17587
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 17582-17587
    • Mauzeroll, J.1    Bard, A.J.2    Owhadian, O.3    Monks, T.J.4
  • 35
    • 7644229837 scopus 로고    scopus 로고
    • Dual microelectrodes for distance control and detection of nitric oxide from endothelial cells by means of scanning electrochemical microscope
    • Isik S., Etienne M., Oni J., Blochl A., Reiter S., and Schuhmann W. Dual microelectrodes for distance control and detection of nitric oxide from endothelial cells by means of scanning electrochemical microscope. Anal Chem 76 (2004) 6389-6394
    • (2004) Anal Chem , vol.76 , pp. 6389-6394
    • Isik, S.1    Etienne, M.2    Oni, J.3    Blochl, A.4    Reiter, S.5    Schuhmann, W.6
  • 36
    • 1242319361 scopus 로고    scopus 로고
    • Proliferation assay on a silicon chip applicable for tumors extirpated from mammalians
    • Torisawa Y., Shiku H., Kasai S., Nishizawa M., and Matsue T. Proliferation assay on a silicon chip applicable for tumors extirpated from mammalians. Int J Cancer 109 (2004) 302-308
    • (2004) Int J Cancer , vol.109 , pp. 302-308
    • Torisawa, Y.1    Shiku, H.2    Kasai, S.3    Nishizawa, M.4    Matsue, T.5
  • 37
    • 23844512252 scopus 로고    scopus 로고
    • Real-time monitoring of reactive oxygen species production during differentiation of human monocytic cell lines (THP-1)
    • Kasai S., Shiku H., Torisawa Y., Noda H., Yoshitake J., Shiraishi T., et al. Real-time monitoring of reactive oxygen species production during differentiation of human monocytic cell lines (THP-1). Anal Chim Acta 549 (2005) 14-19
    • (2005) Anal Chim Acta , vol.549 , pp. 14-19
    • Kasai, S.1    Shiku, H.2    Torisawa, Y.3    Noda, H.4    Yoshitake, J.5    Shiraishi, T.6
  • 38
    • 0037695223 scopus 로고    scopus 로고
    • Scanning electrochemical microscopy-based drug sensitivity test for a cell culture integrated in silicon microstructures
    • Torisawa Y., Kaya T., Takii Y., Oyamatsu D., Nishizawa M., and Matsue T. Scanning electrochemical microscopy-based drug sensitivity test for a cell culture integrated in silicon microstructures. Anal Chem 75 (2003) 2154-2158
    • (2003) Anal Chem , vol.75 , pp. 2154-2158
    • Torisawa, Y.1    Kaya, T.2    Takii, Y.3    Oyamatsu, D.4    Nishizawa, M.5    Matsue, T.6
  • 40
    • 28744437275 scopus 로고    scopus 로고
    • High functional hollow fiber membrane modified with phospholipid polymers for a liver assist bioreactor
    • Ye S.H., Watanabe J., Takai M., Iwasaki Y., and Ishihara K. High functional hollow fiber membrane modified with phospholipid polymers for a liver assist bioreactor. Biomaterials 27 (2006) 1955-1962
    • (2006) Biomaterials , vol.27 , pp. 1955-1962
    • Ye, S.H.1    Watanabe, J.2    Takai, M.3    Iwasaki, Y.4    Ishihara, K.5
  • 41
    • 9644255820 scopus 로고    scopus 로고
    • Multi-channel 3-D cell culture device integrated on a silicon chip for anticancer drug sensitivity test
    • Torisawa Y., Shiku H., Yasukawa T., Nishizawa M., and Matsue T. Multi-channel 3-D cell culture device integrated on a silicon chip for anticancer drug sensitivity test. Biomaterials 26 (2005) 2165-2172
    • (2005) Biomaterials , vol.26 , pp. 2165-2172
    • Torisawa, Y.1    Shiku, H.2    Yasukawa, T.3    Nishizawa, M.4    Matsue, T.5
  • 42
    • 0037701271 scopus 로고    scopus 로고
    • Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types
    • Kelm J.M., Timmins N.E., Brown C.J., Fussenegger M., and Nielsen L.M. Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types. Biotechnol Bioeng 83 (2003) 173-180
    • (2003) Biotechnol Bioeng , vol.83 , pp. 173-180
    • Kelm, J.M.1    Timmins, N.E.2    Brown, C.J.3    Fussenegger, M.4    Nielsen, L.M.5
  • 43
    • 20244374691 scopus 로고    scopus 로고
    • Three-dimensional high-density culture of HepG2 cells in a 5-ml radial-flow bioreactor for construction of artificial liver
    • Hongo T., Kajikawa M., Ishida S., Ozawa S., Ohno Y., Sawada J.-I., et al. Three-dimensional high-density culture of HepG2 cells in a 5-ml radial-flow bioreactor for construction of artificial liver. J Biosci Bioeng 99 (2005) 237-244
    • (2005) J Biosci Bioeng , vol.99 , pp. 237-244
    • Hongo, T.1    Kajikawa, M.2    Ishida, S.3    Ozawa, S.4    Ohno, Y.5    Sawada, J.-I.6
  • 44
    • 11144337396 scopus 로고    scopus 로고
    • A practical note on the use of cytotoxicity assays
    • Weyermann J., Lochmann D., and Zimmer A. A practical note on the use of cytotoxicity assays. Int J Pharm 288 (2005) 369-376
    • (2005) Int J Pharm , vol.288 , pp. 369-376
    • Weyermann, J.1    Lochmann, D.2    Zimmer, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.