Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 32, 2014, Pages 11592-11599

  Cornu, Marion ^a   Oppliger, Wolfgang ^a   Albert, Verena ^a   Robitaille, Aaron M ^a   Trapani, Francesca ^b   Quagliata, Luca ^b   Fuhrer, Tobias ^c   Sauer, Uwe ^c   Terracciano, Luigi ^b   Hall, Michael N ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c ETH ZURICH   (Switzerland)

Author keywords

Behavior; Hepatocellular carcinoma; Metabolic stress; TSC

Indexed keywords

CRYPTOCHROME 1; CRYPTOCHROME 2; FIBROBLAST GROWTH FACTOR 21; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUTAMINE; INITIATION FACTOR 2ALPHA; LEPTIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; PER1 PROTEIN; PER2 PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN KINASE B; RAPAMYCIN; RETINOID RELATED ORPHAN RECEPTOR ALPHA; RETINOID RELATED ORPHAN RECEPTOR GAMMA; THYROXINE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; CORRELATION ANALYSIS; FATTY ACID OXIDATION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HUMAN; HUMAN TISSUE; LIPID HOMEOSTASIS; LIPID METABOLISM; LIVER; LOCOMOTION; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THERMOGENESIS; THERMOREGULATION; TRIACYLGLYCEROL BLOOD LEVEL; UNFOLDED PROTEIN RESPONSE;

BEHAVIOR; HEPATOCELLULAR CARCINOMA; METABOLIC STRESS; TSC;

ANIMALS; BODY TEMPERATURE; CARCINOMA, HEPATOCELLULAR; FIBROBLAST GROWTH FACTORS; GENE KNOCKDOWN TECHNIQUES; GLUTAMINE; HUMANS; LIPID METABOLISM; LIVER; LIVER NEOPLASMS; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; MULTIPROTEIN COMPLEXES; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 84905977025     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1412047111     Document Type: Article

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