-
1
-
-
77951765345
-
Subtle variations in Pten dose determine cancer susceptibility
-
A. Alimonti, A. Carracedo, J.G. Clohessy, L.C. Trotman, C. Nardella, and A. Egia Subtle variations in Pten dose determine cancer susceptibility Nature Genetics 42 5 2010 454 458
-
(2010)
Nature Genetics
, vol.42
, Issue.5
, pp. 454-458
-
-
Alimonti, A.1
Carracedo, A.2
Clohessy, J.G.3
Trotman, L.C.4
Nardella, C.5
Egia, A.6
-
3
-
-
0346106146
-
Retinoblastoma tumor suppressor targets dNTP metabolism to regulate DNA replication
-
10.1074/jbc.M205911200
-
S.P. Angus, L.J. Wheeler, S.A. Ranmal, X. Zhang, M.P. Markey, and C.K. Mathews Retinoblastoma tumor suppressor targets dNTP metabolism to regulate DNA replication Journal of Biological Chemistry 277 46 2002 44376 44384 10.1074/jbc.M205911200
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.46
, pp. 44376-44384
-
-
Angus, S.P.1
Wheeler, L.J.2
Ranmal, S.A.3
Zhang, X.4
Markey, M.P.5
Mathews, C.K.6
-
4
-
-
84883486720
-
Inhibition of AMPK and Krebs cycle gene expression drives metabolic remodeling of Pten-deficient preneoplastic thyroid cells
-
V.G. Antico Arciuch, M.A. Russo, K.S. Kang, and A. Di Cristofano Inhibition of AMPK and Krebs cycle gene expression drives metabolic remodeling of Pten-deficient preneoplastic thyroid cells Cancer Research 73 17 2013 5459 5472
-
(2013)
Cancer Research
, vol.73
, Issue.17
, pp. 5459-5472
-
-
Antico Arciuch, V.G.1
Russo, M.A.2
Kang, K.S.3
Di Cristofano, A.4
-
5
-
-
0033575290
-
Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1
-
A. Barthel, S.T. Okino, J. Liao, K. Nakatani, J. Li, and J.P. Whitlock Jr. Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1 The Journal of Biological Chemistry 274 29 1999 20281 20286
-
(1999)
The Journal of Biological Chemistry
, vol.274
, Issue.29
, pp. 20281-20286
-
-
Barthel, A.1
Okino, S.T.2
Liao, J.3
Nakatani, K.4
Li, J.5
Whitlock, Jr.J.P.6
-
6
-
-
33750432183
-
Nuclear factor-[kappa]B and inhibitor of [kappa]B kinase pathways in oncogenic initiation and progression
-
D.S. Basseres, and A.S. Baldwin Nuclear factor-[kappa]B and inhibitor of [kappa]B kinase pathways in oncogenic initiation and progression Oncogene 25 51 2006 6817
-
(2006)
Oncogene
, vol.25
, Issue.51
, pp. 6817
-
-
Basseres, D.S.1
Baldwin, A.S.2
-
7
-
-
77951706304
-
Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis
-
10.1158/0008-5472.can-09-4290
-
D.S. Bassères, A. Ebbs, E. Levantini, and A.S. Baldwin Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis Cancer Research 70 9 2010 3537 3546 10.1158/0008-5472.can-09-4290
-
(2010)
Cancer Research
, vol.70
, Issue.9
, pp. 3537-3546
-
-
Bassères, D.S.1
Ebbs, A.2
Levantini, E.3
Baldwin, A.S.4
-
8
-
-
33745918951
-
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
-
K. Bensaad, A. Tsuruta, M.A. Selak, M.N. Vidal, K. Nakano, and R. Bartrons TIGAR, a p53-inducible regulator of glycolysis and apoptosis Cell 126 1 2006 107 120
-
(2006)
Cell
, vol.126
, Issue.1
, pp. 107-120
-
-
Bensaad, K.1
Tsuruta, A.2
Selak, M.A.3
Vidal, M.N.4
Nakano, K.5
Bartrons, R.6
-
9
-
-
84874995247
-
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1
-
I. Ben-Sahra, J.J. Howell, J.M. Asara, and B.D. Manning Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1 Science 339 6125 2013 1323 1328
-
(2013)
Science
, vol.339
, Issue.6125
, pp. 1323-1328
-
-
Ben-Sahra, I.1
Howell, J.J.2
Asara, J.M.3
Manning, B.D.4
-
10
-
-
84887430076
-
Metabolic regulation by p53 family members
-
C.R. Berkers, O.D. Maddocks, E.C. Cheung, I. Mor, and K.H. Vousden Metabolic regulation by p53 family members Cell Metabolism 18 5 2013 617 633
-
(2013)
Cell Metabolism
, vol.18
, Issue.5
, pp. 617-633
-
-
Berkers, C.R.1
Maddocks, O.D.2
Cheung, E.C.3
Mor, I.4
Vousden, K.H.5
-
11
-
-
80052507407
-
E2F transcription factor-1 regulates oxidative metabolism
-
E. Blanchet, J.-S. Annicotte, S. Lagarrigue, V. Aguilar, C. Clape, and C. Chavey E2F transcription factor-1 regulates oxidative metabolism Nature Cell Biology 13 9 2011 1146
-
(2011)
Nature Cell Biology
, vol.13
, Issue.9
, pp. 1146
-
-
Blanchet, E.1
Annicotte, J.-S.2
Lagarrigue, S.3
Aguilar, V.4
Clape, C.5
Chavey, C.6
-
12
-
-
59749096845
-
Prolyl hydroxylases as regulators of cell metabolism
-
10.1042/BST0370291 BST0370291 [pii]
-
H. Boulahbel, R.V. Duran, and E. Gottlieb Prolyl hydroxylases as regulators of cell metabolism Biochemical Society Transactions 37 Pt 1 2009 291 294 10.1042/BST0370291 BST0370291 [pii]
-
(2009)
Biochemical Society Transactions
, vol.37
, Issue.PART 1
, pp. 291-294
-
-
Boulahbel, H.1
Duran, R.V.2
Gottlieb, E.3
-
14
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
L.C. Cantley The phosphoinositide 3-kinase pathway Science 296 5573 2002 1655 1657
-
(2002)
Science
, vol.296
, Issue.5573
, pp. 1655-1657
-
-
Cantley, L.C.1
-
15
-
-
51849084360
-
The PTEN-PI3K pathway: Of feedbacks and cross-talks
-
A. Carracedo, and P.P. Pandolfi The PTEN-PI3K pathway: Of feedbacks and cross-talks Oncogene 27 41 2008 5527 5541
-
(2008)
Oncogene
, vol.27
, Issue.41
, pp. 5527-5541
-
-
Carracedo, A.1
Pandolfi, P.P.2
-
16
-
-
84865959001
-
A metabolic prosurvival role for PML in breast cancer
-
A. Carracedo, D. Weiss, A.K. Leliaert, M. Bhasin, V.C. de Boer, and G. Laurent A metabolic prosurvival role for PML in breast cancer The Journal of Clinical Investigation 122 9 2012 3088 3100
-
(2012)
The Journal of Clinical Investigation
, vol.122
, Issue.9
, pp. 3088-3100
-
-
Carracedo, A.1
Weiss, D.2
Leliaert, A.K.3
Bhasin, M.4
De Boer, V.C.5
Laurent, G.6
-
17
-
-
77955170881
-
Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression
-
Z. Chen, Y. Li, H. Zhang, P. Huang, and R. Luthra Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression Oncogene 29 30 2010 4362
-
(2010)
Oncogene
, vol.29
, Issue.30
, pp. 4362
-
-
Chen, Z.1
Li, Y.2
Zhang, H.3
Huang, P.4
Luthra, R.5
-
18
-
-
0035937715
-
Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia
-
C. Chen, N. Pore, A. Behrooz, F. Ismail-Beigi, and A. Maity Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia The Journal of Biological Chemistry 276 2001 9519
-
(2001)
The Journal of Biological Chemistry
, vol.276
, pp. 9519
-
-
Chen, C.1
Pore, N.2
Behrooz, A.3
Ismail-Beigi, F.4
Maity, A.5
-
19
-
-
78149341677
-
Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1alpha and HIF-2alpha target genes
-
S.Y. Chun, C. Johnson, J.G. Washburn, M.R. Cruz-Correa, D.T. Dang, and L.H. Dang Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1alpha and HIF-2alpha target genes Molecular Cancer 9 2010 293
-
(2010)
Molecular Cancer
, vol.9
, pp. 293
-
-
Chun, S.Y.1
Johnson, C.2
Washburn, J.G.3
Cruz-Correa, M.R.4
Dang, D.T.5
Dang, L.H.6
-
20
-
-
3042818799
-
Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
-
M.N. Corradetti, K. Inoki, N. Bardeesy, R.A. DePinho, and K.-L. Guan Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome Genes & Development 18 13 2004 1533 1538
-
(2004)
Genes & Development
, vol.18
, Issue.13
, pp. 1533-1538
-
-
Corradetti, M.N.1
Inoki, K.2
Bardeesy, N.3
Depinho, R.A.4
Guan, K.-L.5
-
21
-
-
33745885329
-
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
-
D. Crighton, S. Wilkinson, J. O'Prey, N. Syed, P. Smith, and P.R. Harrison DRAM, a p53-induced modulator of autophagy, is critical for apoptosis Cell 126 1 2006 121
-
(2006)
Cell
, vol.126
, Issue.1
, pp. 121
-
-
Crighton, D.1
Wilkinson, S.2
O'Prey, J.3
Syed, N.4
Smith, P.5
Harrison, P.R.6
-
22
-
-
84878584543
-
The tumor suppressor Rb critically regulates starvation-induced stress response in C. E
-
M. Cui, M.L. Cohen, C. Teng, and M. Han The tumor suppressor Rb critically regulates starvation-induced stress response in C. elegans Current Biology 23 11 2013 975
-
(2013)
Current Biology
, vol.23
, Issue.11
, pp. 975
-
-
Cui, M.1
Cohen, M.L.2
Teng, C.3
Han, M.4
-
24
-
-
59649101100
-
AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development
-
B. Dasgupta, and J. Milbrandt AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development Developmental Cell 16 2 2009 256
-
(2009)
Developmental Cell
, vol.16
, Issue.2
, pp. 256
-
-
Dasgupta, B.1
Milbrandt, J.2
-
26
-
-
0030748651
-
Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades
-
J. Deprez, D. Vertommen, D.R. Alessi, L. Hue, and M.H. Rider Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades The Journal of Biological Chemistry 272 28 1997 17269 17275
-
(1997)
The Journal of Biological Chemistry
, vol.272
, Issue.28
, pp. 17269-17275
-
-
Deprez, J.1
Vertommen, D.2
Alessi, D.R.3
Hue, L.4
Rider, M.H.5
-
27
-
-
0026561121
-
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
-
L.A. Donehower, M. Harvey, B.L. Slagle, M.J. McArthur, C.A. Montgomery Jr., and J.S. Butel Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours Nature 356 6366 1992 215 221
-
(1992)
Nature
, vol.356
, Issue.6366
, pp. 215-221
-
-
Donehower, L.A.1
Harvey, M.2
Slagle, B.L.3
McArthur, M.J.4
Montgomery, Jr.C.A.5
Butel, J.S.6
-
28
-
-
84881453767
-
TAp73 enhances the pentose phosphate pathway and supports cell proliferation
-
W. Du, P. Jiang, A. Mancuso, A. Stonestrom, M.D. Brewer, and A.J. Minn TAp73 enhances the pentose phosphate pathway and supports cell proliferation Nature Cell Biology 15 8 2013 991 1000
-
(2013)
Nature Cell Biology
, vol.15
, Issue.8
, pp. 991-1000
-
-
Du, W.1
Jiang, P.2
Mancuso, A.3
Stonestrom, A.4
Brewer, M.D.5
Minn, A.J.6
-
29
-
-
77955483125
-
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
-
K. Düvel, J.L. Yecies, S. Menon, P. Raman, A.I. Lipovsky, and A.L. Souza Activation of a metabolic gene regulatory network downstream of mTOR complex 1 Molecular Cell 39 2 2010 171
-
(2010)
Molecular Cell
, vol.39
, Issue.2
, pp. 171
-
-
Düvel, K.1
Yecies, J.L.2
Menon, S.3
Raman, P.4
Lipovsky, A.I.5
Souza, A.L.6
-
30
-
-
2542561169
-
Akt stimulates aerobic glycolysis in cancer cells
-
10.1158/0008-5472.can-03-2904
-
R.L. Elstrom, D.E. Bauer, M. Buzzai, R. Karnauskas, M.H. Harris, and D.R. Plas Akt stimulates aerobic glycolysis in cancer cells Cancer Research 64 11 2004 3892 3899 10.1158/0008-5472.can-03-2904
-
(2004)
Cancer Research
, vol.64
, Issue.11
, pp. 3892-3899
-
-
Elstrom, R.L.1
Bauer, D.E.2
Buzzai, M.3
Karnauskas, R.4
Harris, M.H.5
Plas, D.R.6
-
31
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
J.A. Engelman, J. Luo, and L.C. Cantley The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism Nature Reviews. Genetics 7 8 2006 606 619
-
(2006)
Nature Reviews. Genetics
, vol.7
, Issue.8
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
32
-
-
84872159532
-
AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo
-
B. Faubert, G. Boily, S. Izreig, T. Griss, B. Samborska, and Z. Dong AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo Cell Metabolism 17 1 2012 113 124
-
(2012)
Cell Metabolism
, vol.17
, Issue.1
, pp. 113-124
-
-
Faubert, B.1
Boily, G.2
Izreig, S.3
Griss, T.4
Samborska, B.5
Dong, Z.6
-
33
-
-
77956402239
-
MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU
-
10.1371/journal.pone.0010345
-
E. Favaro, A. Ramachandran, R. McCormick, H. Gee, C. Blancher, and M. Crosby MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU PLoS One 5 4 2010 e10345 10.1371/journal.pone.0010345
-
(2010)
PLoS One
, vol.5
, Issue.4
, pp. 10345
-
-
Favaro, E.1
Ramachandran, A.2
McCormick, R.3
Gee, H.4
Blancher, C.5
Crosby, M.6
-
34
-
-
0030882666
-
Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation
-
10.1074/jbc.272.39.24113
-
T.S. Finco, J.K. Westwick, J.L. Norris, A.A. Beg, C.J. Der, and A.S. Baldwin Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation Journal of Biological Chemistry 272 39 1997 24113 24116 10.1074/jbc.272.39.24113
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.39
, pp. 24113-24116
-
-
Finco, T.S.1
Westwick, J.K.2
Norris, J.L.3
Beg, A.A.4
Der, C.J.5
Baldwin, A.S.6
-
35
-
-
33947724515
-
HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
-
10.1016/j.cell.2007.01.047 S0092-8674(07)00307-8 [pii]
-
R. Fukuda, H. Zhang, J.W. Kim, L. Shimoda, C.V. Dang, and G.L. Semenza HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells Cell 129 1 2007 111 122 10.1016/j.cell.2007.01.047 S0092-8674(07)00307-8 [pii]
-
(2007)
Cell
, vol.129
, Issue.1
, pp. 111-122
-
-
Fukuda, R.1
Zhang, H.2
Kim, J.W.3
Shimoda, L.4
Dang, C.V.5
Semenza, G.L.6
-
36
-
-
64749116346
-
C-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
-
P. Gao, I. Tchernyshyov, T.-C. Chang, Y.-S. Lee, K. Kita, and T. Ochi c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism Nature 458 7239 2009 762
-
(2009)
Nature
, vol.458
, Issue.7239
, pp. 762
-
-
Gao, P.1
Tchernyshyov, I.2
Chang, T.-C.3
Lee, Y.-S.4
Kita, K.5
Ochi, T.6
-
37
-
-
84859215796
-
Systemic elevation of PTEN induces a tumor-suppressive metabolic state
-
I. Garcia-Cao, M.S. Song, R.M. Hobbs, G. Laurent, C. Giorgi, and V.C. de Boer Systemic elevation of PTEN induces a tumor-suppressive metabolic state Cell 149 1 2012 49 62
-
(2012)
Cell
, vol.149
, Issue.1
, pp. 49-62
-
-
Garcia-Cao, I.1
Song, M.S.2
Hobbs, R.M.3
Laurent, G.4
Giorgi, C.5
De Boer, V.C.6
-
38
-
-
77649259296
-
MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells
-
J. Godlewski, M.O. Nowicki, A. Bronisz, G. Nuovo, J. Palatini, and M. De Lay MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells Molecular Cell 37 5 2010 620
-
(2010)
Molecular Cell
, vol.37
, Issue.5
, pp. 620
-
-
Godlewski, J.1
Nowicki, M.O.2
Bronisz, A.3
Nuovo, G.4
Palatini, J.5
De Lay, M.6
-
39
-
-
14744284578
-
C-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase i
-
C. Grandori, N. Gomez-Roman, Z.A. Felton-Edkins, C. Ngouenet, D.A. Galloway, and R.N. Eisenman c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I Nature Cell Biology 7 3 2005 311
-
(2005)
Nature Cell Biology
, vol.7
, Issue.3
, pp. 311
-
-
Grandori, C.1
Gomez-Roman, N.2
Felton-Edkins, Z.A.3
Ngouenet, C.4
Galloway, D.A.5
Eisenman, R.N.6
-
40
-
-
34347220473
-
Defining the role of mTOR in cancer
-
D.A. Guertin, and D.M. Sabatini Defining the role of mTOR in cancer Cancer Cell 12 1 2007 9
-
(2007)
Cancer Cell
, vol.12
, Issue.1
, pp. 9
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
41
-
-
79952228407
-
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
-
J.Y. Guo, H.Y. Chen, R. Mathew, J. Fan, A.M. Strohecker, and G. Karsli-Uzunbas Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis Genes & Development 25 5 2011 460 470
-
(2011)
Genes & Development
, vol.25
, Issue.5
, pp. 460-470
-
-
Guo, J.Y.1
Chen, H.Y.2
Mathew, R.3
Fan, J.4
Strohecker, A.M.5
Karsli-Uzunbas, G.6
-
42
-
-
84867411346
-
Adenosine monophosphate-activated protein kinase: A central regulator of metabolism with roles in diabetes, cancer, and viral infection
-
10.1101/sqb.2011.76.010819
-
D.G. Hardie Adenosine monophosphate-activated protein kinase: A central regulator of metabolism with roles in diabetes, cancer, and viral infection Cold Spring Harbor Symposia on Quantitative Biology 76 2011 155 164 10.1101/sqb.2011.76.010819
-
(2011)
Cold Spring Harbor Symposia on Quantitative Biology
, vol.76
, pp. 155-164
-
-
Hardie, D.G.1
-
43
-
-
4444376712
-
Signaling to NF-KB
-
10.1101/gad.1228704
-
M.S. Hayden, and S. Ghosh Signaling to NF-KB Genes & Development 18 18 2004 2195 2224 10.1101/gad.1228704
-
(2004)
Genes & Development
, vol.18
, Issue.18
, pp. 2195-2224
-
-
Hayden, M.S.1
Ghosh, S.2
-
44
-
-
79960006190
-
13C-Pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression
-
S. Hu, A. Balakrishnan, R.A. Bok, B. Anderton, P.E.Z. Larson, and S.J. Nelson 13C-Pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression Cell Metabolism 14 1 2011 131 142
-
(2011)
Cell Metabolism
, vol.14
, Issue.1
, pp. 131-142
-
-
Hu, S.1
Balakrishnan, A.2
Bok, R.A.3
Anderton, B.4
Larson, P.E.Z.5
Nelson, S.J.6
-
45
-
-
77952212178
-
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
-
W. Hu, C. Zhang, R. Wu, Y. Sun, A. Levine, and Z. Feng Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function Proceedings of the National Academy of Sciences of the United States of America 107 16 2010 7455 7460
-
(2010)
Proceedings of the National Academy of Sciences of the United States of America
, vol.107
, Issue.16
, pp. 7455-7460
-
-
Hu, W.1
Zhang, C.2
Wu, R.3
Sun, Y.4
Levine, A.5
Feng, Z.6
-
46
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
K. Inoki, T. Zhu, and K.-L. Guan TSC2 mediates cellular energy response to control cell growth and survival Cell 115 5 2003 577
-
(2003)
Cell
, vol.115
, Issue.5
, pp. 577
-
-
Inoki, K.1
Zhu, T.2
Guan, K.-L.3
-
47
-
-
84863763440
-
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
-
S.M. Jeon, N.S. Chandel, and N. Hay AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress Nature 485 7400 2012 661 665
-
(2012)
Nature
, vol.485
, Issue.7400
, pp. 661-665
-
-
Jeon, S.M.1
Chandel, N.S.2
Hay, N.3
-
48
-
-
20844449238
-
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
-
R.G. Jones, D.R. Plas, S. Kubek, M. Buzzai, J. Mu, and Y. Xu AMP-activated protein kinase induces a p53-dependent metabolic checkpoint Molecular Cell 18 3 2005 283
-
(2005)
Molecular Cell
, vol.18
, Issue.3
, pp. 283
-
-
Jones, R.G.1
Plas, D.R.2
Kubek, S.3
Buzzai, M.4
Mu, J.5
Xu, Y.6
-
49
-
-
43649093915
-
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
-
W.G. Kaelin, and P.J. Ratcliffe Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway Molecular Cell 30 4 2008 393
-
(2008)
Molecular Cell
, vol.30
, Issue.4
, pp. 393
-
-
Kaelin, W.G.1
Ratcliffe, P.J.2
-
50
-
-
0030812331
-
Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
-
M. Kaghad, H. Bonnet, A. Yang, L. Creancier, J.C. Biscan, and A. Valent Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers Cell 90 4 1997 809 819
-
(1997)
Cell
, vol.90
, Issue.4
, pp. 809-819
-
-
Kaghad, M.1
Bonnet, H.2
Yang, A.3
Creancier, L.4
Biscan, J.C.5
Valent, A.6
-
51
-
-
43049139541
-
P53 regulates glucose metabolism through an IKK-NF-[kappa]B pathway and inhibits cell transformation
-
K. Kawauchi, K. Araki, K. Tobiume, and N. Tanaka p53 regulates glucose metabolism through an IKK-NF-[kappa]B pathway and inhibits cell transformation Nature Cell Biology 10 5 2008 611
-
(2008)
Nature Cell Biology
, vol.10
, Issue.5
, pp. 611
-
-
Kawauchi, K.1
Araki, K.2
Tobiume, K.3
Tanaka, N.4
-
52
-
-
35649014840
-
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
-
J.W. Kim, P. Gao, Y.C. Liu, G.L. Semenza, and C.V. Dang Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1 Molecular and Cellular Biology 27 2007 7381
-
(2007)
Molecular and Cellular Biology
, vol.27
, pp. 7381
-
-
Kim, J.W.1
Gao, P.2
Liu, Y.C.3
Semenza, G.L.4
Dang, C.V.5
-
53
-
-
48649085816
-
Regulation of TORC1 by Rag GTPases in nutrient response
-
E. Kim, P. Goraksha-Hicks, L. Li, T.P. Neufeld, and K.L. Guan Regulation of TORC1 by Rag GTPases in nutrient response Nature Cell Biology 10 8 2008 935 945
-
(2008)
Nature Cell Biology
, vol.10
, Issue.8
, pp. 935-945
-
-
Kim, E.1
Goraksha-Hicks, P.2
Li, L.3
Neufeld, T.P.4
Guan, K.L.5
-
54
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
-
J.W. Kim, I. Tchernyshyov, G.L. Semenza, and C.V. Dang HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia Cell Metabolism 3 3 2006 177 185
-
(2006)
Cell Metabolism
, vol.3
, Issue.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
55
-
-
0029908016
-
Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
-
A.D. Kohn, S.A. Summers, M.J. Birnbaum, and R.A. Roth Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation The Journal of Biological Chemistry 271 49 1996 31372 31378
-
(1996)
The Journal of Biological Chemistry
, vol.271
, Issue.49
, pp. 31372-31378
-
-
Kohn, A.D.1
Summers, S.A.2
Birnbaum, M.J.3
Roth, R.A.4
-
56
-
-
50049109789
-
AMP-activated protein kinase and human cancer: Cancer metabolism revisited
-
F.P. Kuhajda AMP-activated protein kinase and human cancer: Cancer metabolism revisited International Journal of Obesity 32 Suppl. 4 2008 S36 S41
-
(2008)
International Journal of Obesity
, vol.32
, Issue.SUPPL.. 4
-
-
Kuhajda, F.P.1
-
57
-
-
60549095396
-
Kinase activity-independent suppression of p73α by AMP-activated kinase α (AMPKα)
-
Y.G. Lee, S.W. Lee, H.S. Sin, E.J. Kim, and S.J. Um Kinase activity-independent suppression of p73α by AMP-activated kinase α (AMPKα) Oncogene 28 7 2008 1040 1052
-
(2008)
Oncogene
, vol.28
, Issue.7
, pp. 1040-1052
-
-
Lee, Y.G.1
Lee, S.W.2
Sin, H.S.3
Kim, E.J.4
Um, S.J.5
-
58
-
-
21744442902
-
Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis
-
F. Li Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis Molecular and Cellular Biology 25 2005 6225
-
(2005)
Molecular and Cellular Biology
, vol.25
, pp. 6225
-
-
Li, F.1
-
59
-
-
84861973567
-
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence
-
T. Li, N. Kon, L. Jiang, M. Tan, T. Ludwig, and Y. Zhao Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence Cell 149 6 2012 1269 1283
-
(2012)
Cell
, vol.149
, Issue.6
, pp. 1269-1283
-
-
Li, T.1
Kon, N.2
Jiang, L.3
Tan, M.4
Ludwig, T.5
Zhao, Y.6
-
60
-
-
84887123920
-
Molecular Pathways: Targeting MYC-induced Metabolic Reprogramming and Oncogenic Stress in Cancer
-
B. Li, and M.C. Simon Molecular Pathways: Targeting MYC-induced Metabolic Reprogramming and Oncogenic Stress in Cancer Clinical Cancer Research 19 21 2013 5835 5841
-
(2013)
Clinical Cancer Research
, vol.19
, Issue.21
, pp. 5835-5841
-
-
Li, B.1
Simon, M.C.2
-
61
-
-
84867021989
-
Transcriptional amplification in tumor cells with elevated c-Myc
-
10.1016/j.cell.2012.08.026 S0092-8674(12)01057-4 [pii]
-
C.Y. Lin, J. Loven, P.B. Rahl, R.M. Paranal, C.B. Burge, and J.E. Bradner Transcriptional amplification in tumor cells with elevated c-Myc Cell 151 1 2012 56 67 10.1016/j.cell.2012.08.026 S0092-8674(12)01057-4 [pii]
-
(2012)
Cell
, vol.151
, Issue.1
, pp. 56-67
-
-
Lin, C.Y.1
Loven, J.2
Rahl, P.B.3
Paranal, R.M.4
Burge, C.B.5
Bradner, J.E.6
-
62
-
-
84868010349
-
Revisiting global gene expression analysis
-
J. Loven, D.A. Orlando, A.A. Sigova, C.Y. Lin, P.B. Rahl, and C.B. Burge Revisiting global gene expression analysis Cell 151 3 2012 476
-
(2012)
Cell
, vol.151
, Issue.3
, pp. 476
-
-
Loven, J.1
Orlando, D.A.2
Sigova, A.A.3
Lin, C.Y.4
Rahl, P.B.5
Burge, C.B.6
-
63
-
-
84872905650
-
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
-
10.1038/nature11743 nature11743 [pii]
-
O.D. Maddocks, C.R. Berkers, S.M. Mason, L. Zheng, K. Blyth, and E. Gottlieb Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells Nature 493 7433 2013 542 546 10.1038/nature11743 nature11743 [pii]
-
(2013)
Nature
, vol.493
, Issue.7433
, pp. 542-546
-
-
Maddocks, O.D.1
Berkers, C.R.2
Mason, S.M.3
Zheng, L.4
Blyth, K.5
Gottlieb, E.6
-
64
-
-
48849105341
-
Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells
-
S. Mannava, V. Grachtchouk, L.J. Wheeler, M. Im, D. Zhuang, and E.G. Slavina Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells Cell Cycle 7 15 2008 2392
-
(2008)
Cell Cycle
, vol.7
, Issue.15
, pp. 2392
-
-
Mannava, S.1
Grachtchouk, V.2
Wheeler, L.J.3
Im, M.4
Zhuang, D.5
Slavina, E.G.6
-
65
-
-
34250788809
-
AKT/PKB signaling: Navigating downstream
-
B.D. Manning, and L.C. Cantley AKT/PKB signaling: Navigating downstream Cell 129 7 2007 1261 1274
-
(2007)
Cell
, vol.129
, Issue.7
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
66
-
-
33745149291
-
P53 regulates mitochondrial respiration
-
10.1126/science.1126863
-
S. Matoba, J.-G. Kang, W.D. Patino, A. Wragg, M. Boehm, and O. Gavrilova p53 regulates mitochondrial respiration Science 312 5780 2006 1650 1653 10.1126/science.1126863
-
(2006)
Science
, vol.312
, Issue.5780
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.-G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
-
67
-
-
80053539605
-
NF-kappaB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration
-
10.1038/ncb2324 ncb2324 [pii]
-
C. Mauro, S.C. Leow, E. Anso, S. Rocha, A.K. Thotakura, and L. Tornatore NF-kappaB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration Nature Cell Biology 13 10 2011 1272 1279 10.1038/ncb2324 ncb2324 [pii]
-
(2011)
Nature Cell Biology
, vol.13
, Issue.10
, pp. 1272-1279
-
-
Mauro, C.1
Leow, S.C.2
Anso, E.3
Rocha, S.4
Thotakura, A.K.5
Tornatore, L.6
-
68
-
-
53049087909
-
Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells
-
T. McFate, A. Mohyeldin, H. Lu, J. Thakar, J. Henriques, N.D. Halim, and A. Verma Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells The Journal of Biological Chemistry 283 33 2008 22700 22708
-
(2008)
The Journal of Biological Chemistry
, vol.283
, Issue.33
, pp. 22700-22708
-
-
McFate, T.1
Mohyeldin, A.2
Lu, H.3
Thakar, J.4
Henriques, J.5
Halim, N.D.6
Verma, A.7
-
69
-
-
72949083368
-
Common corruption of the mTOR signaling network in human tumors
-
S. Menon, and B.D. Manning Common corruption of the mTOR signaling network in human tumors Oncogene 27 S2 2009 S43
-
(2009)
Oncogene
, vol.27
, Issue.S2
, pp. 43
-
-
Menon, S.1
Manning, B.D.2
-
70
-
-
84859090262
-
Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice
-
S. Menon, J.L. Yecies, H.H. Zhang, J.J. Howell, J. Nicholatos, and E. Harputlugil Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice Science Signaling 5 217 2012 ra24
-
(2012)
Science Signaling
, vol.5
, Issue.217
, pp. 24
-
-
Menon, S.1
Yecies, J.L.2
Zhang, H.H.3
Howell, J.J.4
Nicholatos, J.5
Harputlugil, E.6
-
71
-
-
70449109147
-
Requirement for NF-[kgr]B signalling in a mouse model of lung adenocarcinoma
-
E. Meylan, A.L. Dooley, D.M. Feldser, L. Shen, E. Turk, and C. Ouyang Requirement for NF-[kgr]B signalling in a mouse model of lung adenocarcinoma Nature 462 7269 2009 104
-
(2009)
Nature
, vol.462
, Issue.7269
, pp. 104
-
-
Meylan, E.1
Dooley, A.L.2
Feldser, D.M.3
Shen, L.4
Turk, E.5
Ouyang, C.6
-
73
-
-
84887621106
-
The multiple connections between pRB and cell metabolism
-
B.N. Nicolay, and N.J. Dyson The multiple connections between pRB and cell metabolism Current Opinion in Cell Biology 25 6 2013 735 740
-
(2013)
Current Opinion in Cell Biology
, vol.25
, Issue.6
, pp. 735-740
-
-
Nicolay, B.N.1
Dyson, N.J.2
-
74
-
-
84873039208
-
Loss of RBF1 changes glutamine catabolism
-
10.1101/gad.206227.112
-
B.N. Nicolay, P.A. Gameiro, K. Tschöp, M. Korenjak, A.M. Heilmann, and J.M. Asara Loss of RBF1 changes glutamine catabolism Genes & Development 27 2 2013 182 196 10.1101/gad.206227.112
-
(2013)
Genes & Development
, vol.27
, Issue.2
, pp. 182-196
-
-
Nicolay, B.N.1
Gameiro, P.A.2
Tschöp, K.3
Korenjak, M.4
Heilmann, A.M.5
Asara, J.M.6
-
75
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
I. Papandreou, R.A. Cairns, L. Fontana, A.L. Lim, and N.C. Denko HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption Cell Metabolism 3 3 2006 187 197
-
(2006)
Cell Metabolism
, vol.3
, Issue.3
, pp. 187-197
-
-
Papandreou, I.1
Cairns, R.A.2
Fontana, L.3
Lim, A.L.4
Denko, N.C.5
-
76
-
-
0042692855
-
Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity
-
M.A. Resnick, and A. Inga Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity Proceedings of the National Academy of Sciences of the United States of America 100 17 2003 9934 9939
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.17
, pp. 9934-9939
-
-
Resnick, M.A.1
Inga, A.2
-
77
-
-
84895071580
-
Control of glutamine metabolism by the tumor suppressor Rb
-
M.R. Reynolds, A.N. Lane, B. Robertson, S. Kemp, Y. Liu, and B.G. Hill et al. Control of glutamine metabolism by the tumor suppressor Rb Oncogene 33 5 2014 556 566
-
(2014)
Oncogene
, vol.33
, Issue.5
, pp. 556-566
-
-
Reynolds, M.R.1
Lane, A.N.2
Robertson, B.3
Kemp, S.4
Liu, Y.5
Hill, B.G.6
-
78
-
-
84874961313
-
Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis
-
10.1126/science.1228771 science.1228771, [pii]
-
A.M. Robitaille, S. Christen, M. Shimobayashi, M. Cornu, L.L. Fava, and S. Moes Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis Science 339 6125 2013 1320 1323 10.1126/science.1228771 science.1228771, [pii]
-
(2013)
Science
, vol.339
, Issue.6125
, pp. 1320-1323
-
-
Robitaille, A.M.1
Christen, S.2
Shimobayashi, M.3
Cornu, M.4
Fava, L.L.5
Moes, S.6
-
79
-
-
84866497949
-
TAp73 depletion accelerates aging through metabolic dysregulation
-
A. Rufini, M.V. Niklison-Chirou, S. Inoue, R. Tomasini, I.S. Harris, and A. Marino TAp73 depletion accelerates aging through metabolic dysregulation Genes & Development 26 18 2012 2009 2014
-
(2012)
Genes & Development
, vol.26
, Issue.18
, pp. 2009-2014
-
-
Rufini, A.1
Niklison-Chirou, M.V.2
Inoue, S.3
Tomasini, R.4
Harris, I.S.5
Marino, A.6
-
80
-
-
77951768486
-
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
Y. Sancak, L. Bar-Peled, R. Zoncu, A.L. Markhard, S. Nada, and D.M. Sabatini Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids Cell 141 2 2010 290 303
-
(2010)
Cell
, vol.141
, Issue.2
, pp. 290-303
-
-
Sancak, Y.1
Bar-Peled, L.2
Zoncu, R.3
Markhard, A.L.4
Nada, S.5
Sabatini, D.M.6
-
81
-
-
39449110058
-
Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis
-
10.1101/gad.1627208
-
V.G. Sankaran, S.H. Orkin, and C.R. Walkley Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis Genes & Development 22 4 2008 463 475 10.1101/gad.1627208
-
(2008)
Genes & Development
, vol.22
, Issue.4
, pp. 463-475
-
-
Sankaran, V.G.1
Orkin, S.H.2
Walkley, C.R.3
-
82
-
-
1942506067
-
The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression
-
F. Schwartzenberg-Bar-Yoseph, M. Armoni, and E. Karnieli The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression Cancer Research 64 7 2004 2627 2633
-
(2004)
Cancer Research
, vol.64
, Issue.7
, pp. 2627-2633
-
-
Schwartzenberg-Bar-Yoseph, F.1
Armoni, M.2
Karnieli, E.3
-
83
-
-
0036290846
-
Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate
-
J.W. Scott, D.G. Norman, S.A. Hawley, L. Kontogiannis, and D.G. Hardie Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate Journal of Molecular Biology 317 2 2002 309 323
-
(2002)
Journal of Molecular Biology
, vol.317
, Issue.2
, pp. 309-323
-
-
Scott, J.W.1
Norman, D.G.2
Hawley, S.A.3
Kontogiannis, L.4
Hardie, D.G.5
-
84
-
-
80055022978
-
The LKB1 complex-AMPK pathway: The tree that hides the forest
-
M. Sebbagh, S. Olschwang, M.J. Santoni, and J.P. Borg The LKB1 complex-AMPK pathway: The tree that hides the forest Familial Cancer 10 3 2011 415 424
-
(2011)
Familial Cancer
, vol.10
, Issue.3
, pp. 415-424
-
-
Sebbagh, M.1
Olschwang, S.2
Santoni, M.J.3
Borg, J.P.4
-
85
-
-
76349095132
-
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
-
G.L. Semenza Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics Oncogene 29 5 2010 625 634
-
(2010)
Oncogene
, vol.29
, Issue.5
, pp. 625-634
-
-
Semenza, G.L.1
-
86
-
-
84866601479
-
Regulation of metabolism by hypoxia-inducible factor 1
-
10.1101/sqb.2011.76.010678
-
G.L. Semenza Regulation of metabolism by hypoxia-inducible factor 1 Cold Spring Harbor Symposia on Quantitative Biology 76 2011 347 353 10.1101/sqb.2011.76.010678
-
(2011)
Cold Spring Harbor Symposia on Quantitative Biology
, vol.76
, pp. 347-353
-
-
Semenza, G.L.1
-
87
-
-
67749111502
-
The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
-
D.B. Shackelford, and R.J. Shaw The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression Nature Reviews. Cancer 9 8 2009 563
-
(2009)
Nature Reviews. Cancer
, vol.9
, Issue.8
, pp. 563
-
-
Shackelford, D.B.1
Shaw, R.J.2
-
88
-
-
67650480092
-
MTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
-
D.B. Shackelford, D.S. Vasquez, J. Corbeil, S. Wu, M. Leblanc, and C.L. Wu mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome Proceedings of the National Academy of Sciences of the United States of America 106 27 2009 11137 11142
-
(2009)
Proceedings of the National Academy of Sciences of the United States of America
, vol.106
, Issue.27
, pp. 11137-11142
-
-
Shackelford, D.B.1
Vasquez, D.S.2
Corbeil, J.3
Wu, S.4
Leblanc, M.5
Wu, C.L.6
-
89
-
-
63249089044
-
Rb regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-Ras isoprenylation
-
A. Shamma, Y. Takegami, T. Miki, S. Kitajima, M. Noda, and T. Obara Rb regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-Ras isoprenylation Cancer Cell 15 4 2009 255
-
(2009)
Cancer Cell
, vol.15
, Issue.4
, pp. 255
-
-
Shamma, A.1
Takegami, Y.2
Miki, T.3
Kitajima, S.4
Noda, M.5
Obara, T.6
-
90
-
-
3142594193
-
The LKB1 tumor suppressor negatively regulates mTOR signaling
-
R.J. Shaw, N. Bardeesy, B.D. Manning, L. Lopez, M. Kosmatka, and R.A. DePinho The LKB1 tumor suppressor negatively regulates mTOR signaling Cancer Cell 6 1 2004 91 99
-
(2004)
Cancer Cell
, vol.6
, Issue.1
, pp. 91-99
-
-
Shaw, R.J.1
Bardeesy, N.2
Manning, B.D.3
Lopez, L.4
Kosmatka, M.5
Depinho, R.A.6
-
91
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
R.J. Shaw, M. Kosmatka, N. Bardeesy, R.L. Hurley, L.A. Witters, and R.A. DePinho The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress Proceedings of the National Academy of Sciences of the United States of America 101 10 2004 3329 3335
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.10
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
Depinho, R.A.6
-
92
-
-
0030921103
-
C-Myc transactivation of LDH-A: Implications for tumor metabolism and growth
-
H. Shim, C. Dolde, B.C. Lewis, C.S. Wu, G. Dang, and R.A. Jungmann c-Myc transactivation of LDH-A: Implications for tumor metabolism and growth Proceedings of the National Academy of Sciences of the United States of America 94 13 1997 6658 6663
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.13
, pp. 6658-6663
-
-
Shim, H.1
Dolde, C.2
Lewis, B.C.3
Wu, C.S.4
Dang, G.5
Jungmann, R.A.6
-
93
-
-
84875894714
-
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
-
J. Son, C.A. Lyssiotis, H. Ying, X. Wang, S. Hua, and M. Ligorio Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway Nature 496 7443 2013 101
-
(2013)
Nature
, vol.496
, Issue.7443
, pp. 101
-
-
Son, J.1
Lyssiotis, C.A.2
Ying, H.3
Wang, X.4
Hua, S.5
Ligorio, M.6
-
94
-
-
0035751937
-
Assessing TP53 status in human tumours to evaluate clinical outcome
-
T. Soussi, and C. Beroud Assessing TP53 status in human tumours to evaluate clinical outcome Nature Reviews. Cancer 1 3 2001 233 240
-
(2001)
Nature Reviews. Cancer
, vol.1
, Issue.3
, pp. 233-240
-
-
Soussi, T.1
Beroud, C.2
-
95
-
-
0034854091
-
Regulation of PTEN transcription by p53
-
V. Stambolic, D. MacPherson, D. Sas, Y. Lin, B. Snow, and Y. Jang Regulation of PTEN transcription by p53 Molecular Cell 8 2 2001 317 325
-
(2001)
Molecular Cell
, vol.8
, Issue.2
, pp. 317-325
-
-
Stambolic, V.1
MacPherson, D.2
Sas, D.3
Lin, Y.4
Snow, B.5
Jang, Y.6
-
96
-
-
84885350394
-
Autophagy sustains mitochondrial glutamine metabolism and growth of BRAFV600E-driven lung tumors
-
A.M. Strohecker, J.Y. Guo, G. Karsli-Uzunbas, S.M. Price, G.J. Chen, and R. Mathew et al. Autophagy sustains mitochondrial glutamine metabolism and growth of BRAFV600E-driven lung tumors Cancer Discovery 3 11 2013 1272 1285
-
(2013)
Cancer Discovery
, vol.3
, Issue.11
, pp. 1272-1285
-
-
Strohecker, A.M.1
Guo, J.Y.2
Karsli-Uzunbas, G.3
Price, S.M.4
Chen, G.J.5
Mathew, R.6
-
97
-
-
77952227625
-
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
-
S. Suzuki, T. Tanaka, M.V. Poyurovsky, H. Nagano, T. Mayama, and S. Ohkubo Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species Proceedings of the National Academy of Sciences of the United States of America 107 16 2010 7461 7466
-
(2010)
Proceedings of the National Academy of Sciences of the United States of America
, vol.107
, Issue.16
, pp. 7461-7466
-
-
Suzuki, S.1
Tanaka, T.2
Poyurovsky, M.V.3
Nagano, H.4
Mayama, T.5
Ohkubo, S.6
-
98
-
-
79952289342
-
Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency
-
P. Tandon, C.A. Gallo, S. Khatri, J.F. Barger, H. Yepiskoposyan, and D.R. Plas Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency Proceedings of the National Academy of Sciences of the United States of America 108 6 2011 2361 2365
-
(2011)
Proceedings of the National Academy of Sciences of the United States of America
, vol.108
, Issue.6
, pp. 2361-2365
-
-
Tandon, P.1
Gallo, C.A.2
Khatri, S.3
Barger, J.F.4
Yepiskoposyan, H.5
Plas, D.R.6
-
99
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
M.G. Vander Heiden, L.C. Cantley, and C.B. Thompson Understanding the Warburg effect: The metabolic requirements of cell proliferation Science 324 5930 2009 1029 1033
-
(2009)
Science
, vol.324
, Issue.5930
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
100
-
-
77949920493
-
MYC as a regulator of ribosome biogenesis and protein synthesis
-
J. van Riggelen, A. Yetil, and D.W. Felsher MYC as a regulator of ribosome biogenesis and protein synthesis Nature Reviews. Cancer 10 4 2010 301
-
(2010)
Nature Reviews. Cancer
, vol.10
, Issue.4
, pp. 301
-
-
Van Riggelen, J.1
Yetil, A.2
Felsher, D.W.3
-
101
-
-
0035677961
-
Treatment resistance of solid tumors: Role of hypoxia and anemia
-
10.1385/MO:18:4:243 MO:18:4:243 [pii]
-
P. Vaupel, O. Thews, and M. Hoeckel Treatment resistance of solid tumors: Role of hypoxia and anemia Medical Oncology 18 4 2001 243 259 10.1385/MO:18:4:243 MO:18:4:243 [pii]
-
(2001)
Medical Oncology
, vol.18
, Issue.4
, pp. 243-259
-
-
Vaupel, P.1
Thews, O.2
Hoeckel, M.3
-
102
-
-
21344473888
-
K-ras codon-specific mutations produce distinctive metabolic phenotypes in NIH3T3 mice [corrected] fibroblasts
-
P. Vizan, L.G. Boros, A. Figueras, G. Capella, R. Mangues, and S. Bassilian K-ras codon-specific mutations produce distinctive metabolic phenotypes in NIH3T3 mice [corrected] fibroblasts Cancer Research 65 13 2005 5512 5515
-
(2005)
Cancer Research
, vol.65
, Issue.13
, pp. 5512-5515
-
-
Vizan, P.1
Boros, L.G.2
Figueras, A.3
Capella, G.4
Mangues, R.5
Bassilian, S.6
-
104
-
-
77957937428
-
Targeting mitochondrial glutaminase activity inhibits oncogenic transformation
-
J.B. Wang, J.W. Erickson, R. Fuji, S. Ramachandran, P. Gao, and R. Dinavahi Targeting mitochondrial glutaminase activity inhibits oncogenic transformation Cancer Cell 18 3 2010 207 219
-
(2010)
Cancer Cell
, vol.18
, Issue.3
, pp. 207-219
-
-
Wang, J.B.1
Erickson, J.W.2
Fuji, R.3
Ramachandran, S.4
Gao, P.5
Dinavahi, R.6
-
105
-
-
84885357137
-
Exploiting the bad eating habits of Ras-driven cancers
-
10.1101/gad.228122.113 27/19/2065 [pii]
-
E. White Exploiting the bad eating habits of Ras-driven cancers Genes & Development 27 19 2013 2065 2071 10.1101/gad.228122.113 27/19/2065 [pii]
-
(2013)
Genes & Development
, vol.27
, Issue.19
, pp. 2065-2071
-
-
White, E.1
-
106
-
-
10744230065
-
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
-
A. Woods, S.R. Johnstone, K. Dickerson, F.C. Leiper, L.G. Fryer, and D. Neumann LKB1 is the upstream kinase in the AMP-activated protein kinase cascade Current Biology 13 22 2003 2004 2008
-
(2003)
Current Biology
, vol.13
, Issue.22
, pp. 2004-2008
-
-
Woods, A.1
Johnstone, S.R.2
Dickerson, K.3
Leiper, F.C.4
Fryer, L.G.5
Neumann, D.6
-
107
-
-
32044465506
-
TOR signaling in growth and metabolism
-
S. Wullschleger, R. Loewith, and M.N. Hall TOR signaling in growth and metabolism Cell 124 3 2006 471 484
-
(2006)
Cell
, vol.124
, Issue.3
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
108
-
-
79954517977
-
Structure of mammalian AMPK and its regulation by ADP
-
B. Xiao, M.J. Sanders, E. Underwood, R. Heath, F.V. Mayer, and D. Carmena Structure of mammalian AMPK and its regulation by ADP Nature 472 7342 2011 230 233
-
(2011)
Nature
, vol.472
, Issue.7342
, pp. 230-233
-
-
Xiao, B.1
Sanders, M.J.2
Underwood, E.3
Heath, R.4
Mayer, F.V.5
Carmena, D.6
-
109
-
-
0032161624
-
P63, a p53 homologue at 3q27-29, encodes multiple products with transactivating, deathinducing, and dominant-negative activities
-
A. Yang, M. Kaghad, Y. Wang, E. Gillett, M.D. Fleming, and V. Dötsch p63, a p53 homologue at 3q27-29, encodes multiple products with transactivating, deathinducing, and dominant-negative activities Molecular Cell 2 3 1998 305 316
-
(1998)
Molecular Cell
, vol.2
, Issue.3
, pp. 305-316
-
-
Yang, A.1
Kaghad, M.2
Wang, Y.3
Gillett, E.4
Fleming, M.D.5
Dötsch, V.6
-
110
-
-
84870885534
-
EGFR-induced and PKC' monoubiquitylation-dependent NF-kappaB activation upregulates PKM2 expression and promotes tumorigenesis
-
W. Yang, Y. Xia, Y. Cao, Y. Zheng, W. Bu, and L. Zhang EGFR-induced and PKC' monoubiquitylation-dependent NF-kappaB activation upregulates PKM2 expression and promotes tumorigenesis Molecular Cell 48 5 2012 771
-
(2012)
Molecular Cell
, vol.48
, Issue.5
, pp. 771
-
-
Yang, W.1
Xia, Y.2
Cao, Y.3
Zheng, Y.4
Bu, W.5
Zhang, L.6
-
111
-
-
84860321700
-
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
-
H. Ying, A.C. Kimmelman, C.A. Lyssiotis, S. Hua, G.C. Chu, and E. Fletcher-Sananikone Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism Cell 149 3 2012 656
-
(2012)
Cell
, vol.149
, Issue.3
, pp. 656
-
-
Ying, H.1
Kimmelman, A.C.2
Lyssiotis, C.A.3
Hua, S.4
Chu, G.C.5
Fletcher-Sananikone, E.6
-
112
-
-
43649104579
-
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
-
10.1074/jbc.M800102200
-
H. Zhang, M. Bosch-Marce, L.A. Shimoda, Y.S. Tan, J.H. Baek, and J.B. Wesley Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia Journal of Biological Chemistry 283 16 2008 10892 10903 10.1074/jbc.M800102200
-
(2008)
Journal of Biological Chemistry
, vol.283
, Issue.16
, pp. 10892-10903
-
-
Zhang, H.1
Bosch-Marce, M.2
Shimoda, L.A.3
Tan, Y.S.4
Baek, J.H.5
Wesley, J.B.6
-
113
-
-
70350564782
-
Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth
-
Y.H. Zhao, M. Zhou, H. Liu, Y. Ding, H.T. Khong, and D. Yu Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth Oncogene 28 42 2009 3689 3701
-
(2009)
Oncogene
, vol.28
, Issue.42
, pp. 3689-3701
-
-
Zhao, Y.H.1
Zhou, M.2
Liu, H.3
Ding, Y.4
Khong, H.T.5
Yu, D.6
-
114
-
-
58649110598
-
Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation
-
B. Zheng, J.H. Jeong, J.M. Asara, Y.Y. Yuan, S.R. Granter, and L. Chin Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation Molecular Cell 33 2 2009 237 247
-
(2009)
Molecular Cell
, vol.33
, Issue.2
, pp. 237-247
-
-
Zheng, B.1
Jeong, J.H.2
Asara, J.M.3
Yuan, Y.Y.4
Granter, S.R.5
Chin, L.6
|