P63/p73 in the control of cell cycle and cell death

Experimental Cell Research

Volumn 318, Issue 11, 2012, Pages 1285-1290

  Allocati, N ^a   Di Ilio, C ^a,b   De Laurenzi, V ^a,b,c  

^a UNIVERSITY OF CHIETI   (Italy)

^b Centro Studi sull'Invecchiamento   (Italy)

^c UNIVERSITY OF SALERNO   (Italy)

Author keywords

Cell cycle; Cell death; P63; P73

Indexed keywords

PROTEIN P63; PROTEIN P73;

CELL CYCLE REGULATION; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; DNA DAMAGE; GERM LINE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FUNCTION; REVIEW; SOMATIC CELL;

VERTEBRATA;

EID: 84861664029     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2012.01.023     Document Type: Review

References (63)

1. Belyi V.A., Ak P., Markert E., Wang H., Hu W., Puzio-Kuter A., Levine A.J. The origins and evolution of the p53 family of genes. Cold Spring Harb. Perspect. Biol. 2010, 2:a001198.
2. De Laurenzi V., Costanzo A., Barcaroli D., Terrinoni A., Falco M., Annicchiarico-Petruzzelli M., Levrero M., Melino G. Two new p73 splice variants, gamma and delta, with different transcriptional activity. J. Exp. Med. 1998, 188:1763-1768.
3. De Laurenzi V., Melino G. Evolution of functions within the p53/p63/p73 family. Ann. N. Y. Acad. Sci. 2000, 926:90-100.
4. De Laurenzi V.D., Catani M.V., Terrinoni A., Corazzari M., Melino G., Costanzo A., Levrero M., Knight R.A. Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants epsilon and zeta. Cell Death Differ. 1999, 6:389-390.
5. Levrero M., De Laurenzi V., Costanzo A., Gong J., Wang J.Y., Melino G. The p53/p63/p73 family of transcription factors: overlapping and distinct functions. J. Cell Sci. 2000, 113(Pt 10):1661-1670.
6. Grob T.J., Novak U., Maisse C., Barcaroli D., Luthi A.U., Pirnia F., Hugli B., Graber H.U., De Laurenzi V., Fey M.F., Melino G., Tobler A. Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53. Cell Death Differ. 2001, 8:1213-1223.
7. Melino G., De Laurenzi V., Vousden K.H. p73: friend or foe in tumorigenesis. Nat. Rev. Cancer 2002, 2:605-615.
8. Buhlmann S., Putzer B.M. DNp73 a matter of cancer: mechanisms and clinical implications. Biochim. Biophys. Acta 2008, 1785:207-216.
9. Graziano V., De Laurenzi V. Role of p63 in cancer development. Biochim. Biophys. Acta 2011, 1816:57-66.
10. Bourdon J.C. p53 and its isoforms in cancer. Br. J. Cancer 2007, 97:277-282.
11. De Cola A., Bongiorno-Borbone L., Bianchi E., Barcaroli D., Carletti E., Knight R.A., Di Ilio C., Melino G., Sette C., De Laurenzi V. FLASH is essential during early embryogenesis and cooperates with p73 to regulate histone gene transcription. Oncogene 2012, 31:573-582.
12. Tomasini R., Mak T.W., Melino G. The impact of p53 and p73 on aneuploidy and cancer. Trends Cell Biol. 2008, 18:244-252.
13. Tomasini R., Tsuchihara K., Wilhelm M., Fujitani M., Rufini A., Cheung C.C., Khan F., Itie-Youten A., Wakeham A., Tsao M.S., Iovanna J.L., Squire J., Jurisica I., Kaplan D., Melino G., Jurisicova A., Mak T.W. TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev. 2008, 22:2677-2691.
14. Vernole P., Neale M.H., Barcaroli D., Munarriz E., Knight R.A., Tomasini R., Mak T.W., Melino G., De Laurenzi V. TAp73alpha binds the kinetochore proteins Bub1 and Bub3 resulting in polyploidy. Cell Cycle 2009, 8:421-429.
15. Tomasini R., Tsuchihara K., Tsuda C., Lau S.K., Wilhelm M., Ruffini A., Tsao M.S., Iovanna J.L., Jurisicova A., Melino G., Mak T.W. TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:797-802.
16. Collavin L., Lunardi A., Del Sal G. p53-family proteins and their regulators: hubs and spokes in tumor suppression. Cell Death Differ. 2010, 17:901-911.
17. Ramadan S., Terrinoni A., Catani M.V., Sayan A.E., Knight R.A., Mueller M., Krammer P.H., Melino G., Candi E. p73 induces apoptosis by different mechanisms. Biochem. Biophys. Res. Commun. 2005, 331:713-717.
18. Gressner O., Schilling T., Lorenz K., Schulze Schleithoff E., Koch A., Schulze-Bergkamen H., Lena A.M., Candi E., Terrinoni A., Catani M.V., Oren M., Melino G., Krammer P.H., Stremmel W., Muller M. TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO J. 2005, 24:2458-2471.
19. Pietsch E.C., Sykes S.M., McMahon S.B., Murphy M.E. The p53 family and programmed cell death. Oncogene 2008, 27:6507-6521.
20. Zocchi L., Bourdon J.C., Codispoti A., Knight R., Lane D.P., Melino G., Terrinoni A. Scotin: a new p63 target gene expressed during epidermal differentiation. Biochem. Biophys. Res. Commun. 2008, 367:271-276.
21. Schuster A., Schilling T., De Laurenzi V., Koch A.F., Seitz S., Staib F., Teufel A., Thorgeirsson S.S., Galle P., Melino G., Stremmel W., Krammer P.H., Muller M. DeltaNp73beta is oncogenic in hepatocellular carcinoma by blocking apoptosis signaling via death receptors and mitochondria. Cell Cycle 2010, 9:2629-2639.
22. Rastogi S., Rizwani W., Joshi B., Kunigal S., Chellappan S.P. TNF-alpha response of vascular endothelial and vascular smooth muscle cells involve differential utilization of ASK1 kinase and p73. Cell Death Differ 2012, 19. 274-273.
23. Tang V., Dhirapong A., Yabes A.P., Weiss R.H. TNF-alpha-mediated apoptosis in vascular smooth muscle cells requires p73. Am. J. Physiol. Cell Physiol. 2005, 289:C199-C206.
24. Sayan A.E., Sayan B.S., Gogvadze V., Dinsdale D., Nyman U., Hansen T.M., Zhivotovsky B., Cohen G.M., Knight R.A., Melino G. P73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis. Oncogene 2008, 27:4363-4372.
25. Borrelli S., Candi E., Alotto D., Castagnoli C., Melino G., Vigano M.A., Mantovani R. p63 regulates the caspase-8-FLIP apoptotic pathway in epidermis. Cell Death Differ. 2009, 16:253-263.
26. Lee A.F., Ho D.K., Zanassi P., Walsh G.S., Kaplan D.R., Miller F.D. Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms. J. Neurosci. 2004, 24:9174-9184.
27. Bailey S.G., Cragg M.S., Townsend P.A. Family friction as DeltaNp73 antagonises p73 and p53. Int. J. Biochem. Cell Biol. 2011, 43:482-486.
28. Xirodimas D.P., Saville M.K., Bourdon J.C., Hay R.T., Lane D.P. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell 2004, 118:83-97.
29. Rossi M., Aqeilan R.I., Neale M., Candi E., Salomoni P., Knight R.A., Croce C.M., Melino G. The E3 ubiquitin ligase Itch controls the protein stability of p63. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:12753-12758.
30. Rossi M., De Laurenzi V., Munarriz E., Green D.R., Liu Y.C., Vousden K.H., Cesareni G., Melino G. The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J. 2005, 24:836-848.
31. Maisse C., Munarriz E., Barcaroli D., Melino G., De Laurenzi V. DNA damage induces the rapid and selective degradation of the DeltaNp73 isoform, allowing apoptosis to occur. Cell Death Differ. 2004, 11:685-687.
32. Sayan B.S., Yang A.L., Conforti F., Tucci P., Piro M.C., Browne G.J., Agostini M., Bernardini S., Knight R.A., Mak T.W., Melino G. Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:12877-12882.
33. Dulloo I., Gopalan G., Melino G., Sabapathy K. The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:4902-4907.
34. Munarriz E., Barcaroli D., Stephanou A., Townsend P.A., Maisse C., Terrinoni A., Neale M.H., Martin S.J., Latchman D.S., Knight R.A., Melino G., De Laurenzi V. PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73. Mol. Cell. Biol. 2004, 24:10593-10610.
35. Dai J.M., Wang Z.Y., Sun D.C., Lin R.X., Wang S.Q. SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity. J. Cell. Physiol. 2007, 210:161-166.
36. Rufini A., Agostini M., Grespi F., Tomasini R., Sayan B.S., Niklison-Chirou M.V., Conforti F., Velletri T., Mastino A., Mak T.W., Melino G., Knight R.A. p73 in cancer. Genes Cancer 2011, 2:491-502.
37. Melino G., Lu X., Gasco M., Crook T., Knight R.A. Functional regulation of p73 and p63: development and cancer. Trends Biochem. Sci. 2003, 28:663-670.
38. De Laurenzi V., Rossi A., Terrinoni A., Barcaroli D., Levrero M., Costanzo A., Knight R.A., Guerrieri P., Melino G. p63 and p73 transactivate differentiation gene promoters in human keratinocytes. Biochem. Biophys. Res. Commun. 2000, 273:342-346.
39. Levrero M., De Laurenzi V., Costanzo A., Gong J., Melino G., Wang J.Y. Structure, function and regulation of p63 and p73. Cell Death Differ. 1999, 6:1146-1153.
40. Meyer G., Cabrera Socorro A., Perez Garcia C.G., Martinez Millan L., Walker N., Caput D. Developmental roles of p73 in Cajal-Retzius cells and cortical patterning. J. Neurosci. 2004, 24:9878-9887.
41. Yang A., Walker N., Bronson R., Kaghad M., Oosterwegel M., Bonnin J., Vagner C., Bonnet H., Dikkes P., Sharpe A., McKeon F., Caput D. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 2000, 404:99-103.
42. Killick R., Niklison-Chirou M., Tomasini R., Bano D., Rufini A., Grespi F., Velletri T., Tucci P., Sayan B.S., Conforti F., Gallagher E., Nicotera P., Mak T.W., Melino G., Knight R.A., Agostini M. p73: a multifunctional protein in neurobiology. Mol. Neurobiol. 2011, 43:139-146.
43. Wetzel M.K., Naska S., Laliberte C.L., Rymar V.V., Fujitani M., Biernaskie J.A., Cole C.J., Lerch J.P., Spring S., Wang S.H., Frankland P.W., Henkelman R.M., Josselyn S.A., Sadikot A.F., Miller F.D., Kaplan D.R. p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease. Neuron 2008, 59:708-721.
44. Wilhelm M.T., Rufini A., Wetzel M.K., Tsuchihara K., Inoue S., Tomasini R., Itie-Youten A., Wakeham A., Arsenian-Henriksson M., Melino G., Kaplan D.R., Miller F.D., Mak T.W. Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev. 2010, 24:549-560.
45. Meyer G. p73: a complex gene for building a complex brain. Cell Cycle 2011, 10:1188-1189.
46. Tissir F., Ravni A., Achouri Y., Riethmacher D., Meyer G., Goffinet A.M. DeltaNp73 regulates neuronal survival in vivo. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:16871-16876.
47. De Laurenzi V., Raschella G., Barcaroli D., Annicchiarico-Petruzzelli M., Ranalli M., Catani M.V., Tanno B., Costanzo A., Levrero M., Melino G. Induction of neuronal differentiation by p73 in a neuroblastoma cell line. J. Biol. Chem. 2000, 275:15226-15231.
48. M.T. Wilhelm, A. Rufini, M.K. Wetzel, K. Tsuchihara, S. Inoue, R. Tomasini, A. Itie-Youten, A. Wakeham, M. Arsenian-Henriksson, G. Melino, D.R. Kaplan, F.D. Miller, T.W. Mak, Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway, Genes Dev 24 549-560.
49. Holembowski L., Schulz R., Talos F., Scheel A., Wolff S., Dobbelstein M., Moll U. While p73 is essential, p63 is completely dispensable for the development of the central nervous system. Cell Cycle 2011, 10:680-689.
50. Yang A., Schweitzer R., Sun D., Kaghad M., Walker N., Bronson R.T., Tabin C., Sharpe A., Caput D., Crum C., McKeon F. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 1999, 398:714-718.
51. Mills A.A., Zheng B., Wang X.J., Vogel H., Roop D.R., Bradley A. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 1999, 398:708-713.
52. Suh K.Y., Lacouture M., Gerami P. p63 in primary cutaneous carcinosarcoma. Am. J. Dermatopathol. 2007, 29:374-377.
53. Koster M.I., Marinari B., Payne A.S., Kantaputra P.N., Costanzo A., Roop D.R. DeltaNp63 knockdown mice: a mouse model for AEC syndrome. Am. J. Med. Genet. A 2009, 149A:1942-1947.
54. Candi E., Cipollone R., Rivetti di Val Cervo P., Gonfloni S., Melino G., Knight R. p63 in epithelial development. Cell. Mol. Life Sci. 2008, 65:3126-3133.
55. Candi E., Dinsdale D., Rufini A., Salomoni P., Knight R.A., Mueller M., Krammer P.H., Melino G. TAp63 and DeltaNp63 in cancer and epidermal development. Cell Cycle 2007, 6:274-285.
56. Candi E., Rufini A., Terrinoni A., Dinsdale D., Ranalli M., Paradisi A., De Laurenzi V., Spagnoli L.G., Catani M.V., Ramadan S., Knight R.A., Melino G. Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice. Cell Death Differ. 2006, 13:1037-1047.
57. Flores E.R., Sengupta S., Miller J.B., Newman J.J., Bronson R., Crowley D., Yang A., McKeon F., Jacks T. Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. Cancer Cell 2005, 7:363-373.
58. Keyes W.M., Vogel H., Koster M.I., Guo X., Qi Y., Petherbridge K.M., Roop D.R., Bradley A., Mills A.A. p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:8435-8440.
59. Koster M.I., Dai D., Roop D.R. Conflicting roles for p63 in skin development and carcinogenesis. Cell Cycle 2007, 6:269-273.
60. Levine A.J., Tomasini R., McKeon F.D., Mak T.W., Melino G. The p53 family: guardians of maternal reproduction. Nat. Rev. Mol. Cell Biol. 2011, 12:259-265.
61. Suh E.K., Yang A., Kettenbach A., Bamberger C., Michaelis A.H., Zhu Z., Elvin J.A., Bronson R.T., Crum C.P., McKeon F. p63 protects the female germ line during meiotic arrest. Nature 2006, 444:624-628.
62. Gonfloni S., Di Tella L., Caldarola S., Cannata S.M., Klinger F.G., Di Bartolomeo C., Mattei M., Candi E., De Felici M., Melino G., Cesareni G. Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death. Nat. Med. 2009, 15:1179-1185.
63. Hu W., Feng Z., Teresky A.K., Levine A.J. p53 regulates maternal reproduction through LIF. Nature 2007, 450:721-724.