-
1
-
-
0009593158
-
Cancer among infants
-
In: Ries LAG, Smith MA, Gurney JG, et al., eds. Bethesda, MD: National Cancer Institute, SEER Program. NIH
-
Gurney JG, Smith MA, Ross JA. Cancer among infants. In: Ries LAG, Smith MA, Gurney JG, et al., eds. Cancer Incidence and Survival among children and adolescents: United States SEER program 1975-1995. Bethesda, MD: National Cancer Institute, SEER Program. NIH; 1999.
-
(1999)
Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995
-
-
Gurney, J.G.1
Smith, M.A.2
Ross, J.A.3
-
2
-
-
0002097492
-
Leukemia
-
Ries LAG, Smith MA, Gurney JG, et al., eds SEER Program, NIH. Bethesda, MD: National Cancer Institute
-
Smith MA, Gloeckler-Ries LA, Gurney JG, Ross JA. Leukemia. In: Ries LAG, Smith MA, Gurney JG, et al., eds. Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995. Bethesda, MD: National Cancer Institute, SEER Program, NIH; 1999.
-
(1999)
Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995
-
-
Smith, M.A.1
Gloeckler-Ries, L.A.2
Gurney, J.G.3
Ross, J.A.4
-
3
-
-
0029004562
-
Biology and treatment of infant leukemias
-
Pui CH, Kane JR, Crist WM. Biology and treatment of infant leukemias. Leukemia. 1995;9:762-769.
-
(1995)
Leukemia
, vol.9
, pp. 762-769
-
-
Pui, C.H.1
Kane, J.R.2
Crist, W.M.3
-
4
-
-
68749120703
-
New insights to the MLL recombinome of acute leukemias
-
SEER Cancer Statistics Review, 1975-2006; seer.cancer.gov/csr/1975-2006/
-
SEER Cancer Statistics Review, 1975-2006; seer.cancer.gov/csr/1975-2006/ Meyer C, Kowarz E, Hofmann J, et al. New insights to the MLL recombinome of acute leukemias. Leukemia. 2009.
-
(2009)
Leukemia
-
-
Meyer, C.1
Kowarz, E.2
Hofmann, J.3
-
5
-
-
0028229442
-
Frequency and prognostic significance of HRX rearrangements in infant acute lymphoblastic leukemia: A Pediatric Oncology Group study
-
Rubnitz JE, Link MP, Shuster JJ, et al. Frequency and prognostic significance of HRX rearrangements in infant acute lymphoblastic leukemia: a Pediatric Oncology Group study. Blood. 1994;84:570-573.
-
(1994)
Blood
, vol.84
, pp. 570-573
-
-
Rubnitz, J.E.1
Link, M.P.2
Shuster, J.J.3
-
6
-
-
0242500374
-
Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements
-
Pui CH, Chessells JM, Camitta B, et al. Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements. Leukemia. 2003;17:700-706.
-
(2003)
Leukemia
, vol.17
, pp. 700-706
-
-
Pui, C.H.1
Chessells, J.M.2
Camitta, B.3
-
7
-
-
84979855543
-
Specific MLL partner genes in infant acute lymphoblastic leukemia (ALL) associated with outcome are linked to age and white blood cell count (WBC) at diagnosis: A report on the Children's Oncology Group (COG) P9407 trial
-
Robinson BW, Devidas M, Carroll AJ, et al. Specific MLL partner genes in infant acute lymphoblastic leukemia (ALL) associated with outcome are linked to age and white blood cell count (WBC) at diagnosis: A report on the Children's Oncology Group (COG) P9407 trial. Blood (ASH Annual Meeting Abstracts) 2009;114(22):907.
-
(2009)
Blood (ASH Annual Meeting Abstracts
, vol.114
, Issue.22
, pp. 907
-
-
Robinson, B.W.1
Devidas, M.2
Carroll, A.J.3
-
8
-
-
33745961112
-
Analysis of prognostic factors of acute lymphoblastic leukemia in infants: Report on CCG 1953 from the Children's Oncology Group
-
Hilden JM, Dinndorf PA, Meerbaum SO, et al. Analysis of prognostic factors of acute lymphoblastic leukemia in infants: report on CCG 1953 from the Children's Oncology Group. Blood. 2006;108:441-451.
-
(2006)
Blood
, vol.108
, pp. 441-451
-
-
Hilden, J.M.1
Dinndorf, P.A.2
Meerbaum, S.O.3
-
9
-
-
70350497118
-
Novel prognostic subgroups in childhood 11q23/ MLL-rearranged acute myeloid leukemia: Results of an international retrospective study
-
Balgobind BV, Raimondi SC, Harbott J, et al. Novel prognostic subgroups in childhood 11q23/ MLL-rearranged acute myeloid leukemia: results of an international retrospective study. Blood. 2009;114:2489-2496.
-
(2009)
Blood
, vol.114
, pp. 2489-2496
-
-
Balgobind, B.V.1
Raimondi, S.C.2
Harbott, J.3
-
10
-
-
33747892853
-
Topoisomerase II and the etiology of chromosomal translocations
-
Felix CA, Kolaris CP, Osheroff N. Topoisomerase II and the etiology of chromosomal translocations. DNA Repair (Amst). 2006;5:1093-1108.
-
(2006)
DNA Repair (Amst)
, vol.5
, pp. 1093-1108
-
-
Felix, C.A.1
Kolaris, C.P.2
Osheroff, N.3
-
11
-
-
0033008437
-
Secondary leukemia or myelodysplastic syndrome after treatment with epipodophyllotoxins
-
Smith MA, Rubinstein L, Anderson JR, et al. Secondary leukemia or myelodysplastic syndrome after treatment with epipodophyllotoxins. J Clin Oncol. 1999;17:569-577.
-
(1999)
J Clin Oncol
, vol.17
, pp. 569-577
-
-
Smith, M.A.1
Rubinstein, L.2
Anderson, J.R.3
-
13
-
-
0025833975
-
Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias
-
Ziemin-van der Poel S, McCabe NR, Gill HJ, et al. Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc Natl Acad Sci USA. 1991;88:10735-10739.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 10735-10739
-
-
Ziemin-Van Der Poel, S.1
McCabe, N.R.2
Gill, H.J.3
-
14
-
-
0026936328
-
A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias
-
Djabali M, Selleri L, Parry P, Bower M, Young BD, Evans GA. A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias. Nat Genet. 1992;2:113-118.
-
(1992)
Nat Genet
, vol.2
, pp. 113-118
-
-
Djabali, M.1
Selleri, L.2
Parry, P.3
Bower, M.4
Young, B.D.5
Evans, G.A.6
-
15
-
-
0026496887
-
The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene
-
Gu Y, Nakamura T, Alder H, et al. The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell. 1992;71:701-708.
-
(1992)
Cell
, vol.71
, pp. 701-708
-
-
Gu, Y.1
Nakamura, T.2
Alder, H.3
-
16
-
-
0026454451
-
Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias
-
1992
-
Tkachuk DC, Kohler S, Cleary ML. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell. 1992;71:691-700.
-
Cell
, vol.71
, pp. 691-700
-
-
Tkachuk, D.C.1
Kohler, S.2
Cleary, M.L.3
-
17
-
-
0027276927
-
In utero rearrangements in the trithorax-related oncogene in infant leukaemias
-
Ford AM, Ridge SA, Cabrera ME, et al. In utero rearrangements in the trithorax-related oncogene in infant leukaemias. Nature. 1993;363:358-360.
-
(1993)
Nature
, vol.363
, pp. 358-360
-
-
Ford, A.M.1
Ridge, S.A.2
Cabrera, M.E.3
-
18
-
-
11544323440
-
T(11;22)(q23;q11.2) in acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes
-
Megonigal MD, Rappaport EF, Jones DH, et al. t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes. Proc Natl Acad Sci U S A. 1998;95:6413-6418.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 6413-6418
-
-
Megonigal, M.D.1
Rappaport, E.F.2
Jones, D.H.3
-
19
-
-
0037111567
-
Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties
-
Yokoyama A, Kitabayashi I, Ayton PM, Cleary ML, Ohki M. Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties. Blood. 2002;100:3710-3718.
-
(2002)
Blood
, vol.100
, pp. 3710-3718
-
-
Yokoyama, A.1
Kitabayashi, I.2
Ayton, P.M.3
Cleary, M.L.4
Ohki, M.5
-
20
-
-
4644220954
-
MLL: A histone methyltransferase disrupted in leukemia
-
Hess JL. MLL: a histone methyltransferase disrupted in leukemia. Trends Mol Med. 2004;10:500-507.
-
(2004)
Trends Mol Med
, vol.10
, pp. 500-507
-
-
Hess, J.L.1
-
21
-
-
33748269854
-
Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression
-
Takeda S, Chen DY, Westergard TD, et al. Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression. Genes Dev. 2006;20:2397-2409.
-
(2006)
Genes Dev
, vol.20
, pp. 2397-2409
-
-
Takeda, S.1
Chen, D.Y.2
Westergard, T.D.3
-
22
-
-
34948839290
-
Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: A critical regulatory circuit lost in leukemogenic MLL fusions
-
Liu H, Cheng EH, Hsieh JJ. Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions. Genes Dev. 2007;21:2385-2398.
-
(2007)
Genes Dev
, vol.21
, pp. 2385-2398
-
-
Liu, H.1
Cheng, E.H.2
Hsieh, J.J.3
-
23
-
-
18544375333
-
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
-
Armstrong SA, Staunton JE, Silverman LB, et al. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet. 2002;30:41-47.
-
(2002)
Nat Genet
, vol.30
, pp. 41-47
-
-
Armstrong, S.A.1
Staunton, J.E.2
Silverman, L.B.3
-
24
-
-
33646161959
-
The MLL recombinome of acute leukemias
-
Meyer C, Schneider B, Jakob S, et al. The MLL recombinome of acute leukemias. Leukemia. 2006;20:777-784.
-
(2006)
Leukemia
, vol.20
, pp. 777-784
-
-
Meyer, C.1
Schneider, B.2
Jakob, S.3
-
25
-
-
0041370095
-
Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9
-
Ayton PM, Cleary ML. Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev. 2003;17:2298-2307.
-
(2003)
Genes Dev
, vol.17
, pp. 2298-2307
-
-
Ayton, P.M.1
Cleary, M.L.2
-
26
-
-
0141680407
-
Dimerization of MLL fusion proteins immortalizes hematopoietic cells
-
2003
-
Martin ME, Milne TA, Bloyer S, et al. Dimerization of MLL fusion proteins immortalizes hematopoietic cells. Cancer Cell. 2003;4:197-207.
-
Cancer Cell
, vol.4
, pp. 197-207
-
-
Martin, M.E.1
Milne, T.A.2
Bloyer, S.3
-
28
-
-
33749440584
-
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
-
Somervaille TC, Cleary ML. Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell. 2006;10:257-268.
-
(2006)
Cancer Cell
, vol.10
, pp. 257-268
-
-
Somervaille, T.C.1
Cleary, M.L.2
-
29
-
-
33746498580
-
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
-
Krivtsov AV, Twomey D, Feng Z, et al. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature. 2006;442:818-822.
-
(2006)
Nature
, vol.442
, pp. 818-822
-
-
Krivtsov, A.V.1
Twomey, D.2
Feng, Z.3
-
30
-
-
13444311619
-
Conditional MLL-CBP targets GMP and models therapyrelated myeloproliferative disease
-
Wang J, Iwasaki H, Krivtsov A, et al. Conditional MLL-CBP targets GMP and models therapyrelated myeloproliferative disease. EMBO J. 2005;24:368-381.
-
(2005)
EMBO J
, vol.24
, pp. 368-381
-
-
Wang, J.1
Iwasaki, H.2
Krivtsov, A.3
-
32
-
-
1542269168
-
FLT3 inhibitors: A paradigm for the development of targeted therapeutics for paediatric cancer
-
Oxford, England
-
Brown P, Small D. FLT3 inhibitors: a paradigm for the development of targeted therapeutics for paediatric cancer. European journal of cancer (Oxford, England : 1990). 2004;40:707.
-
(1990)
European Journal of Cancer
, vol.40
, pp. 707
-
-
Brown, P.1
Small, D.2
-
34
-
-
13344282746
-
Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias
-
Carow CE, Levenstein M, Kaufmann SH, et al. Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias. Blood. 1996;87:1089.
-
(1996)
Blood
, vol.87
, pp. 1089
-
-
Carow, C.E.1
Levenstein, M.2
Kaufmann, S.H.3
-
35
-
-
9244260192
-
Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells
-
Rosnet O, Buhring HJ, Marchetto S, et al. Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells. Leukemia. 1996;10:238-248.
-
(1996)
Leukemia
, vol.10
, pp. 238-248
-
-
Rosnet, O.1
Buhring, H.J.2
Marchetto, S.3
-
36
-
-
0026457216
-
Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages
-
Birg F, Courcoul M, Rosnet O, et al. Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages. Blood. 1992;80:2584-2593.
-
(1992)
Blood
, vol.80
, pp. 2584-2593
-
-
Birg, F.1
Courcoul, M.2
Rosnet, O.3
-
37
-
-
19044399684
-
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling
-
Yeoh EJ, Ross ME, Shurtleff SA, et al. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell. 2002;1:133-143.
-
(2002)
Cancer Cell
, vol.1
, pp. 133-143
-
-
Yeoh, E.J.1
Ross, M.E.2
Shurtleff, S.A.3
-
38
-
-
0141993002
-
Classification of pediatric acute lymphoblastic leukemia by gene expression profiling
-
Ross ME, Zhou X, Song G, et al. Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood. 2003;102:2951-2959.
-
(2003)
Blood
, vol.102
, pp. 2951-2959
-
-
Ross, M.E.1
Zhou, X.2
Song, G.3
-
39
-
-
9144269029
-
FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells
-
Zheng R, Levis M, Piloto O, et al. FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells. Blood. 2004;103:267.
-
(2004)
Blood
, vol.103
, pp. 267
-
-
Zheng, R.1
Levis, M.2
Piloto, O.3
-
40
-
-
0030002950
-
Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells
-
Drexler HG. Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells. Leukemia. 1996;10:588-599.
-
(1996)
Leukemia
, vol.10
, pp. 588-599
-
-
Drexler, H.G.1
-
41
-
-
0029145627
-
Expression of FLT3 receptor and FLT3-ligand in human leukemia-lymphoma cell lines
-
Meierhoff G, Dehmel U, Gruss HJ, et al. Expression of FLT3 receptor and FLT3-ligand in human leukemia-lymphoma cell lines. Leukemia. 1995;9:1368-1372.
-
(1995)
Leukemia
, vol.9
, pp. 1368-1372
-
-
Meierhoff, G.1
Dehmel, U.2
Gruss, H.J.3
-
42
-
-
0029100754
-
Expression of the flt3 receptor and its ligand on hematopoietic cells
-
Brasel K, Escobar S, Anderberg R, de Vries P, Gruss HJ, Lyman SD. Expression of the flt3 receptor and its ligand on hematopoietic cells. Leukemia. 1995;9:1212-1218.
-
(1995)
Leukemia
, vol.9
, pp. 1212-1218
-
-
Brasel, K.1
Escobar, S.2
Anderberg, R.3
De Vries, P.4
Gruss, H.J.5
Lyman, S.D.6
-
43
-
-
0035871889
-
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
-
Yamamoto Y, Kiyoi H, Nakano Y, et al. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood. 2001;97:2434.
-
(2001)
Blood
, vol.97
, pp. 2434
-
-
Yamamoto, Y.1
Kiyoi, H.2
Nakano, Y.3
-
44
-
-
0034936404
-
Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia
-
Abu-Duhier FM, Goodeve AC, Wilson GA, Care RS, Peake IR, Reilly JT. Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia. Br J Haematol. 2001;113:983-988.
-
(2001)
Br J Haematol
, vol.113
, pp. 983-988
-
-
Abu-Duhier, F.M.1
Goodeve, A.C.2
Wilson, G.A.3
Care, R.S.4
Peake, I.R.5
Reilly, J.T.6
-
45
-
-
0030451722
-
Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
-
Nakao M, Yokota S, Iwai T, et al. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia. 1996;10:1911-1918.
-
(1996)
Leukemia
, vol.10
, pp. 1911-1918
-
-
Nakao, M.1
Yokota, S.2
Iwai, T.3
-
46
-
-
0031883328
-
FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates
-
Lavagna-Sevenier C, Marchetto S, Birnbaum D, Rosnet O. FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates. Leukemia. 1998;12:301-310.
-
(1998)
Leukemia
, vol.12
, pp. 301-310
-
-
Lavagna-Sevenier, C.1
Marchetto, S.2
Birnbaum, D.3
Rosnet, O.4
-
47
-
-
0033020705
-
Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells
-
Zhang S, Mantel C, Broxmeyer HE. Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells. J Leukoc Biol. 1999;65:372-380.
-
(1999)
J Leukoc Biol
, vol.65
, pp. 372-380
-
-
Zhang, S.1
Mantel, C.2
Broxmeyer, H.E.3
-
48
-
-
0034649210
-
Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase
-
Zhang S, Broxmeyer HE. Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase. Biochem Biophys Res Commun. 2000;277:195-199.
-
(2000)
Biochem Biophys Res Commun
, vol.277
, pp. 195-199
-
-
Zhang, S.1
Broxmeyer, H.E.2
-
49
-
-
0034605042
-
Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling
-
Zhang S, Fukuda S, Lee Y, et al. Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling. J Exp Med. 2000;192:719-728.
-
(2000)
J Exp Med
, vol.192
, pp. 719-728
-
-
Zhang, S.1
Fukuda, S.2
Lee, Y.3
-
50
-
-
0031686409
-
Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
-
Kiyoi H, Towatari M, Yokota S, et al. Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia. 1998;12:1333-1337.
-
(1998)
Leukemia
, vol.12
, pp. 1333-1337
-
-
Kiyoi, H.1
Towatari, M.2
Yokota, S.3
-
51
-
-
0037061747
-
Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain
-
Kiyoi H, Ohno R, Ueda R, Saito H, Naoe T. Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain. Oncogene. 2002;21: 2555-2563.
-
(2002)
Oncogene
, vol.21
, pp. 2555-2563
-
-
Kiyoi, H.1
Ohno, R.2
Ueda, R.3
Saito, H.4
Naoe, T.5
-
52
-
-
0035168677
-
Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia
-
Meshinchi S, Woods WG, Stirewalt DL, et al. Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia. Blood. 2001;97:89.
-
(2001)
Blood
, vol.97
, pp. 89
-
-
Meshinchi, S.1
Woods, W.G.2
Stirewalt, D.L.3
-
53
-
-
1542276560
-
FLT3 mutations in childhood acute lymphoblastic leukemia
-
Armstrong SA, Mabon ME, Silverman LB, et al. FLT3 mutations in childhood acute lymphoblastic leukemia. Blood. 2004;103:3544-3546.
-
(2004)
Blood
, vol.103
, pp. 3544-3546
-
-
Armstrong, S.A.1
Mabon, M.E.2
Silverman, L.B.3
-
54
-
-
9144244169
-
FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy
-
Taketani T, Taki T, Sugita K, et al. FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy. Blood. 2004;103:1085-1088.
-
(2004)
Blood
, vol.103
, pp. 1085-1088
-
-
Taketani, T.1
Taki, T.2
Sugita, K.3
-
55
-
-
0037062350
-
PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model
-
Kelly LM, Kutok JL, Williams IR, et al. PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model. Proc Natl Acad Sci U S A. 2002;99:8283-8288.
-
(2002)
Proc Natl Acad Sci U S A.
, vol.99
, pp. 8283-8288
-
-
Kelly, L.M.1
Kutok, J.L.2
Williams, I.R.3
-
56
-
-
0036093475
-
FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model
-
Kelly LM, Liu Q, Kutok JL, Williams IR, Boulton CL, Gilliland DG. FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model. Blood. 2002;99:310-318.
-
(2002)
Blood
, vol.99
, pp. 310-318
-
-
Kelly, L.M.1
Liu, Q.2
Kutok, J.L.3
Williams, I.R.4
Boulton, C.L.5
Gilliland, D.G.6
-
57
-
-
43549123118
-
Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model
-
Li L, Piloto O, Nguyen HB, et al. Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model. Blood. 2008;111:3849-3858.
-
(2008)
Blood
, vol.111
, pp. 3849-3858
-
-
Li, L.1
Piloto, O.2
Nguyen, H.B.3
-
58
-
-
33845254595
-
Clinical implications of FLT3 mutations in pediatric AML
-
Meshinchi S, Alonzo TA, Stirewalt DL, et al. Clinical implications of FLT3 mutations in pediatric AML. Blood. 2006;108:3654.
-
(2006)
Blood
, vol.108
, pp. 3654
-
-
Meshinchi, S.1
Alonzo, T.A.2
Stirewalt, D.L.3
-
59
-
-
0036624916
-
A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo
-
Levis M, Allebach J, Tse KF, et al. A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo. Blood. 2002;99:3885.
-
(2002)
Blood
, vol.99
, pp. 3885
-
-
Levis, M.1
Allebach, J.2
Tse, K.F.3
-
60
-
-
4444342401
-
Pediatric AML primary samples with FLT3/ITD mutations are preferentially killed by FLT3 inhibition
-
Brown P, Meshinchi S, Levis M, et al. Pediatric AML primary samples with FLT3/ITD mutations are preferentially killed by FLT3 inhibition. Blood. 2004;104:1841.
-
(2004)
Blood
, vol.104
, pp. 1841
-
-
Brown, P.1
Meshinchi, S.2
Levis, M.3
-
61
-
-
3843142735
-
In vitro studies of a FLT3 inhibitor combined with chemotherapy: Sequence of administration is important to achieve synergistic cytotoxic effects
-
Levis M, Pham R, Smith BD, Small D. In vitro studies of a FLT3 inhibitor combined with chemotherapy: sequence of administration is important to achieve synergistic cytotoxic effects. Blood. 2004;104:1145.
-
(2004)
Blood
, vol.104
, pp. 1145
-
-
Levis, M.1
Pham, R.2
Smith, B.D.3
Small, D.4
-
62
-
-
1842420032
-
Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia
-
Smith BD, Levis M, Beran M, et al. Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia. Blood. 2004;103:3669-3676.
-
(2004)
Blood
, vol.103
, pp. 3669-3676
-
-
Smith, B.D.1
Levis, M.2
Beran, M.3
-
63
-
-
19944427559
-
Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor PKC412
-
Stone RM, DeAngelo DJ, Klimek V, et al. Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412. Blood. 2005;105:54-60.
-
(2005)
Blood
, vol.105
, pp. 54-60
-
-
Stone, R.M.1
Deangelo, D.J.2
Klimek, V.3
-
64
-
-
11244300074
-
FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression
-
Brown P, Levis M, Shurtleff S, Campana D, Downing J, Small D. FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression. Blood. 2005;105:812-820.
-
(2005)
Blood
, vol.105
, pp. 812-820
-
-
Brown, P.1
Levis, M.2
Shurtleff, S.3
Campana, D.4
Downing, J.5
Small, D.6
-
65
-
-
0041737454
-
Activating mutations of RTK/RAS signal transduction pathway in pediatric acute myeloid leukemia
-
Meshinchi S, Stirewalt DL, Alonzo TA, et al. Activating mutations of RTK/RAS signal transduction pathway in pediatric acute myeloid leukemia. Blood. 2003;102:1474-1479.
-
(2003)
Blood
, vol.102
, pp. 1474-1479
-
-
Meshinchi, S.1
Stirewalt, D.L.2
Alonzo, T.A.3
-
66
-
-
33746149660
-
Combinations of the FLT3 inhibitor CEP-701 and chemotherapy synergistically kill infant and childhood MLL-rearranged ALL cells in a sequence-dependent manner
-
Brown P, Levis M, McIntyre E, Griesemer M, Small D. Combinations of the FLT3 inhibitor CEP-701 and chemotherapy synergistically kill infant and childhood MLL-rearranged ALL cells in a sequence-dependent manner. Leukemia: official journal of the Leukemia Society of America, Leukemia Research Fund, UK. 2006;20:1368.
-
(2006)
Leukemia: Official Journal of the Leukemia Society of America. Leukemia Research Fund, UK.
, vol.20
, pp. 1368
-
-
Brown, P.1
Levis, M.2
McIntyre, E.3
Griesemer, M.4
Small, D.5
-
67
-
-
33646432479
-
IMC-EB10, an anti-FLT3 monoclonal antibody, prolongs survival and reduces nonobese diabetic/severe combined immunodeficient engraftment of some acute lymphoblastic leukemia cell lines and primary leukemic samples
-
Piloto O, Nguyen B, Huso D, et al. IMC-EB10, an anti-FLT3 monoclonal antibody, prolongs survival and reduces nonobese diabetic/severe combined immunodeficient engraftment of some acute lymphoblastic leukemia cell lines and primary leukemic samples. Cancer research. 2006;66:4843.
-
(2006)
Cancer Research
, vol.66
, pp. 4843
-
-
Piloto, O.1
Nguyen, B.2
Huso, D.3
-
68
-
-
14044249427
-
Inhibitory anti-FLT3 antibodies are capable of mediating antibodydependent cell-mediated cytotoxicity and reducing engraftment of acute myelogenous leukemia blasts in nonobese diabetic/severe combined immunodeficient mice
-
Piloto O, Levis M, Huso D, et al. Inhibitory anti-FLT3 antibodies are capable of mediating antibodydependent cell-mediated cytotoxicity and reducing engraftment of acute myelogenous leukemia blasts in nonobese diabetic/severe combined immunodeficient mice. Cancer Res. 2005;65:1514-1522.
-
(2005)
Cancer Res
, vol.65
, pp. 1514-1522
-
-
Piloto, O.1
Levis, M.2
Huso, D.3
-
69
-
-
33751170444
-
Plasma inhibitory activity (PIA): A pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors
-
Levis M, Brown P, Smith BD, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors. Blood. 2006;108:3477-3483.
-
(2006)
Blood
, vol.108
, pp. 3477-3483
-
-
Levis, M.1
Brown, P.2
Smith, B.D.3
-
70
-
-
33747105356
-
Open-label study of lestaurtinib (CEP-701), an oral FLT3 inhibitor, administered in sequence with chemotherapy in patients with relapsed AML harboring FLT3 activating mutations: Clinical response correlates with successful FLT3 inhibition
-
Levis M, Smith BD, Beran M, et al. A randomized, open-label study of lestaurtinib (CEP-701), an oral FLT3 inhibitor, administered in sequence with chemotherapy in patients with relapsed AML harboring FLT3 activating mutations: clinical response correlates with successful FLT3 inhibition. ASH Annual Meeting Abstracts. 2005;106:403.
-
(2005)
ASH Annual Meeting Abstracts
, vol.106
, pp. 403
-
-
Levis, M.1
Smith, B.D.2
Beran, M.3
Randomized, E.A.4
-
71
-
-
44249122620
-
Abundant anti-apoptotic BCL-2 is a molecular target in leukaemias with t(4;11) translocation
-
Robinson BW, Behling KC, Gupta M, et al. Abundant anti-apoptotic BCL-2 is a molecular target in leukaemias with t(4;11) translocation. Br J Haematol. 2008;141:827-839.
-
(2008)
Br J Haematol
, vol.141
, pp. 827-839
-
-
Robinson, B.W.1
Behling, K.C.2
Gupta, M.3
-
72
-
-
84900253498
-
Cell death regulatory gene expression correlates with MLL rearrangement status and prognostic clinical covariates in acute leukemia in infants
-
Zhang AY, Robinson BW, Kao K, et al. Cell death regulatory gene expression correlates with MLL rearrangement status and prognostic clinical covariates in acute leukemia in infants. ASH Annual Meeting Abstracts. 2008;112:2255.
-
(2008)
ASH Annual Meeting Abstracts
, vol.112
, pp. 2255
-
-
Zhang, A.Y.1
Robinson, B.W.2
Kao, K.3
-
73
-
-
20444430478
-
Apoptotic pathways: Ten minutes to dead
-
Green D. Apoptotic pathways: ten minutes to dead. Cell. 2005;121:671-674.
-
(2005)
Cell
, vol.121
, pp. 671-674
-
-
Green, D.1
-
74
-
-
0036463649
-
Apoptosis-based therapies
-
Reed JC. Apoptosis-based therapies. Nat Rev Drug Discov. 2002;1:111-121.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 111-121
-
-
Reed, J.C.1
-
75
-
-
0038786580
-
Apoptosis-targeted therapies for cancer
-
Reed JC. Apoptosis-targeted therapies for cancer. Cancer Cell. 2003;3:17-22.
-
(2003)
Cancer Cell
, vol.3
, pp. 17-22
-
-
Reed, J.C.1
-
76
-
-
0842281645
-
Cell death: Critical control points
-
Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell. 2004;116:205-219.
-
(2004)
Cell
, vol.116
, pp. 205-219
-
-
Danial, N.N.1
Korsmeyer, S.J.2
-
77
-
-
37649023004
-
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
-
Nguyen M, Marcellus RC, Roulston A, et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A. 2007;104:19512-19517.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 19512-19517
-
-
Nguyen, M.1
Marcellus, R.C.2
Roulston, A.3
-
78
-
-
0032147234
-
Nucleic acid therapeutics: State of the art and future prospects
-
Gewirtz AM, Sokol DL, Ratajczak MZ. Nucleic acid therapeutics: state of the art and future prospects. Blood. 1998;92:712-736.
-
(1998)
Blood
, vol.92
, pp. 712-736
-
-
Gewirtz, A.M.1
Sokol, D.L.2
Ratajczak, M.Z.3
-
79
-
-
0036728834
-
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
-
Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S, Korsmeyer SJ. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell. 2002;2:183-192.
-
(2002)
Cancer Cell
, vol.2
, pp. 183-192
-
-
Letai, A.1
Bassik, M.C.2
Walensky, L.D.3
Sorcinelli, M.D.4
Weiler, S.5
Korsmeyer, S.J.6
-
80
-
-
29844440967
-
Targeting mitochondria emerges as therapeutic strategy
-
Garber K. Targeting mitochondria emerges as therapeutic strategy. J Natl Cancer Inst. 2005;97:1800-1801.
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 1800-1801
-
-
Garber, K.1
-
81
-
-
0034641932
-
From bench to clinic with apoptosis based therapeutic agents
-
Nicholson DW. From bench to clinic with apoptosis based therapeutic agents. Nature. 2000;407:810-816.
-
(2000)
Nature
, vol.407
, pp. 810-816
-
-
Nicholson, D.W.1
-
82
-
-
0037438586
-
Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia
-
Marcucci G, Byrd JC, Dai G, et al. Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia. Blood. 2003;101:425-432.
-
(2003)
Blood
, vol.101
, pp. 425-432
-
-
Marcucci, G.1
Byrd, J.C.2
Dai, G.3
-
83
-
-
32944475363
-
Phase i to II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in patients with advanced chronic lymphocytic leukemia
-
O'Brien SM, Cunningham CC, Golenkov AK, Turkina AG, Novick SC, Rai KR. Phase I to II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in patients with advanced chronic lymphocytic leukemia. J Clin Oncol. 2005;23:7697-7702.
-
(2005)
J Clin Oncol
, vol.23
, pp. 7697-7702
-
-
O'brien, S.M.1
Cunningham, C.C.2
Golenkov, A.K.3
Turkina, A.G.4
Novick, S.C.5
Rai, K.R.6
-
84
-
-
0034015672
-
Phase i clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkins lymphoma
-
Waters JS, Webb A, Cunningham D, et al. Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkins lymphoma. J Clin Oncol. 2000;18:1812-1823.
-
(2000)
J Clin Oncol
, vol.18
, pp. 1812-1823
-
-
Waters, J.S.1
Webb, A.2
Cunningham, D.3
-
85
-
-
0142152451
-
Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS
-
Deng X, Gao F, May WS, Jr. Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS. Blood. 2003;102:3179-3185.
-
(2003)
Blood
, vol.102
, pp. 3179-3185
-
-
Deng, X.1
Gao, F.2
May Jr., W.S.3
-
86
-
-
58849086028
-
BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells
-
Huang S, Okumura K, Sinicrope FA. BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells. Clin Cancer Res. 2009;15:150-159.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 150-159
-
-
Huang, S.1
Okumura, K.2
Sinicrope, F.A.3
-
87
-
-
37649016653
-
Anticancer and immunosuppressive properties of bacterial prodiginines
-
Williamson NR, Fineran PC, Gristwood T, Chawrai SR, Leeper FJ, Salmond GP. Anticancer and immunosuppressive properties of bacterial prodiginines. Future Microbiol. 2007;2: 605-618.
-
(2007)
Future Microbiol
, vol.2
, pp. 605-618
-
-
Williamson, N.R.1
Fineran, P.C.2
Gristwood, T.3
Chawrai, S.R.4
Leeper, F.J.5
Salmond, G.P.6
-
88
-
-
33751517366
-
Bcl-2 inhibitors induce apoptosis in chronic lymphocytic leukemia cells
-
Campas C, Cosialls AM, Barragan M, et al. Bcl-2 inhibitors induce apoptosis in chronic lymphocytic leukemia cells. Exp Hematol. 2006;34:1663-1669.
-
(2006)
Exp Hematol
, vol.34
, pp. 1663-1669
-
-
Campas, C.1
Cosialls, A.M.2
Barragan, M.3
-
89
-
-
84900226346
-
The Small Molecule Pan-Bcl-2 Inhibitor GX15-070 Induces Apoptosis in Vitro in Mantle Cell Lymphoma (MCL) Cells and Exhibits a Synergistic Effect in Combination with the Proteasome Inhibitor Bortezomib
-
Galan P, Roue G, Villamor N, Campo E, Colomer D. The Small Molecule Pan-Bcl-2 Inhibitor GX15-070 Induces Apoptosis In Vitro in Mantle Cell Lymphoma (MCL) Cells and Exhibits a Synergistic Effect in Combination with the Proteasome Inhibitor Bortezomib. ASH Annual Meeting Abstracts. 2005;106:1490.
-
(2005)
ASH Annual Meeting Abstracts
, vol.106
, pp. 1490
-
-
Galan, P.1
Roue, G.2
Villamor, N.3
Campo, E.4
Colomer, D.5
-
90
-
-
34248362003
-
The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak
-
Perez-Galan P, Roue G, Villamor N, Campo E, Colomer D. The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak. Blood. 2007;109:4441-4449.
-
(2007)
Blood
, vol.109
, pp. 4441-4449
-
-
Perez-Galan, P.1
Roue, G.2
Villamor, N.3
Campo, E.4
Colomer, D.5
-
91
-
-
37549015758
-
A small molecule pan-Bcl-2 family inhibitor, GX15-070, induces apoptosis and enhances cisplatin-induced apoptosis in non-small cell lung cancer cells
-
Li J, Viallet J, Haura EB. A small molecule pan-Bcl-2 family inhibitor, GX15-070, induces apoptosis and enhances cisplatin-induced apoptosis in non-small cell lung cancer cells. Cancer Chemother Pharmacol. 2007.
-
(2007)
Cancer Chemother Pharmacol
-
-
Li, J.1
Viallet, J.2
Haura, E.B.3
-
92
-
-
37249057877
-
A small molecule pan-Bcl-2 family inhibitor, GX15-070, induces apoptosis and enhances cisplatin-induced apoptosis in non-small cell lung cancer cells
-
Li J, Viallet J, Haura EB. A small molecule pan-Bcl-2 family inhibitor, GX15-070, induces apoptosis and enhances cisplatin-induced apoptosis in non-small cell lung cancer cells. Cancer Chemother Pharmacol. 2008;61:525-534.
-
(2008)
Cancer Chemother Pharmacol
, vol.61
, pp. 525-534
-
-
Li, J.1
Viallet, J.2
Haura, E.B.3
-
93
-
-
84900114692
-
Direct and enhanced cytotoxicity of the Bcl-2 family inhibitor GX15-070 on rituximab-sensitive and rituximab-resistant B-NHL clones
-
Martinez-Paniagua MA, Vega MI, Huerta-Yepez S, et al. Direct and enhanced cytotoxicity of the Bcl-2 family inhibitor GX15-070 on rituximab-sensitive and rituximab-resistant B-NHL clones. ASH Annual Meeting Abstracts. 2007.
-
(2007)
ASH Annual Meeting Abstracts
-
-
Martinez-Paniagua, M.A.1
Vega, M.I.2
Huerta-Yepez, S.3
-
94
-
-
34249982915
-
Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma
-
Trudel S, Li ZH, Rauw J, Tiedemann RE, Wen XY, Stewart AK. Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma. Blood. 2007;109:5430-5438.
-
(2007)
Blood
, vol.109
, pp. 5430-5438
-
-
Trudel, S.1
Li, Z.H.2
Rauw, J.3
Tiedemann, R.E.4
Wen, X.Y.5
Stewart, A.K.6
-
95
-
-
33947732465
-
Synergistic inhibition of breast cancer cell lines with a dual inhibitor of EGFR-HER-2/neu and a Bcl-2 inhibitor
-
Witters LM, Witkoski A, Planas-Silva MD, Berger M, Viallet J, Lipton A. Synergistic inhibition of breast cancer cell lines with a dual inhibitor of EGFR-HER-2/neu and a Bcl-2 inhibitor. Oncol Rep. 2007;17:465-469.
-
(2007)
Oncol Rep.
, vol.17
, pp. 465-469
-
-
Witters, L.M.1
Witkoski, A.2
Planas-Silva, M.D.3
Berger, M.4
Viallet, J.5
Lipton, A.6
-
96
-
-
44849133234
-
Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax)
-
Konopleva M, Watt J, Contractor R, et al. Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax). Cancer Res. 2008;68:3413-3420.
-
(2008)
Cancer Res
, vol.68
, pp. 3413-3420
-
-
Konopleva, M.1
Watt, J.2
Contractor, R.3
-
97
-
-
34249324941
-
In vitro and in vivo anti lymphoma effect of gx15-070 in mantle cell lymphoma
-
Bebb G, Muzik H, Nguyen S, Morris D, Stewart DA. In Vitro and In Vivo Anti Lymphoma Effect of GX15-070 in Mantle Cell Lymphoma. Blood (ASH Annual Meeting Abstracts). 2006;108:4756.
-
(2006)
Blood (ASH Annual Meeting Abstracts)
, vol.108
, pp. 4756
-
-
Bebb, G.1
Muzik, H.2
Nguyen, S.3
Morris, D.4
Stewart, D.A.5
-
98
-
-
77649232859
-
Inhibition of the pan-bcl-2 family by the small molecule gx15-070 induces apoptosis in mantle cell lymphoma (mcl) cells and enhances the activity of two proteasome inhibitors (npi-0052 and bortezomib), and doxorubicin chemotherapy
-
Yazbeck VY, Georgakis GV, Li Y, McConkey D, Andreeff M, Younes A. Inhibition of the Pan-Bcl-2 Family by the Small Molecule GX15-070 Induces Apoptosis in Mantle Cell Lymphoma (MCL) Cells and Enhances the Activity of Two Proteasome Inhibitors (NPI-0052 and Bortezomib), and Doxorubicin Chemotherapy. Blood (ASH Annual Meeting Abstracts). 2006;108:2532.
-
(2006)
Blood (ASH Annual Meeting Abstracts)
, vol.108
, pp. 2532
-
-
Yazbeck, V.Y.1
Georgakis, G.V.2
Li, Y.3
McConkey, D.4
Andreeff, M.5
Younes, A.6
-
99
-
-
84900154992
-
Targeting bh3-domain anti-apoptotic proteins with gx15-070 decreases dna synthesis, induces cell death and sensitizes rituximab-sensitive and resistant non-hodgkins lymphoma cell lines to the anti-tumor activity of chemotherapy agents
-
Hernandez-Ilizaliturri FJ, Iqbal A, Alam N, et al. Targeting BH3-Domain Anti-Apoptotic Proteins with GX15-070 Decreases DNA Synthesis, Induces Cell Death and Sensitizes Rituximab-Sensitive and Resistant Non-Hodgkins Lymphoma Cell Lines to the Anti-Tumor Activity of Chemotherapy Agents. Blood (ASH Annual Meeting Abstracts). 2006;108:2523.
-
(2006)
Blood (ASH Annual Meeting Abstracts)
, vol.108
, pp. 2523
-
-
Hernandez-Ilizaliturri, F.J.1
Iqbal, A.2
Alam, N.3
-
100
-
-
34250371606
-
Targeting bh3-domain anti-apoptotic proteins with gx15-070 significantly increases rituximab-mediated antibody dependent cellular cytotoxicity (adcc) and complement mediated cytotoxicity (cmc) against b-cell lymphomas
-
Hernandez-Ilizaliturri FJ, Bhat S, Iqbal A, Olejniczak S, Knight J, Czuczman MS. Targeting BH3-Domain Anti-Apoptotic Proteins with GX15-070 Significantly Increases Rituximab-Mediated Antibody Dependent Cellular Cytotoxicity (ADCC) and Complement Mediated Cytotoxicity (CMC) Against B-Cell Lymphomas. Blood (ASH Annual Meeting Abstracts). 2006;108:2502.
-
(2006)
Blood (ASH Annual Meeting Abstracts)
, vol.108
, pp. 2502
-
-
Hernandez-Ilizaliturri, F.J.1
Bhat, S.2
Iqbal, A.3
Olejniczak, S.4
Knight, J.5
Czuczman, M.S.6
-
101
-
-
34249321391
-
A phase i trial of the small molecule pan-bcl-2 family inhibitor obatoclax mesylate (gx15-070) administered by 24 hour infusion every 2 weeks to patients with myeloid malignancies and chronic lymphocytic leukemia (cll)
-
Borthakur G, O'Brien S, Ravandi-Kashani F, et al. A Phase I Trial of the Small Molecule Pan-Bcl-2 Family Inhibitor Obatoclax Mesylate (GX15-070) Administered by 24 Hour Infusion Every 2 Weeks to Patients with Myeloid Malignancies and Chronic Lymphocytic Leukemia (CLL). ASH Annual Meeting Abstracts. 2006;108:2654.
-
(2006)
ASH Annual Meeting Abstracts
, vol.108
, pp. 2654
-
-
Borthakur, G.1
O'brien, S.2
Ravandi-Kashani, F.3
-
102
-
-
40849143771
-
A phase 1 trial of the pan Bcl-2 family inhibitor obatoclax mesylate (GX15-070) in combination with bortezomib in patients with relapsed/refractory mantle cell lymphoma
-
Goy A, Ford P, Feldman T, et al. A phase 1 trial of the pan Bcl-2 family inhibitor obatoclax mesylate (GX15-070) in combination with bortezomib in patients with relapsed/refractory mantle cell lymphoma. ASH Annual Meeting Abstracts. 2007.
-
(2007)
ASH Annual Meeting Abstracts
-
-
Goy, A.1
Ford, P.2
Feldman, T.3
-
103
-
-
58849164097
-
Phase i study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia
-
O'Brien SM, Claxton DF, Crump M, et al. Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia. Blood. 2009;113:299-305.
-
(2009)
Blood
, vol.113
, pp. 299-305
-
-
O'brien, S.M.1
Claxton, D.F.2
Crump, M.3
-
104
-
-
40849144773
-
A phase i trial of the small molecule pan-Bcl-2 family inhibitor obatoclax mesylate (GX15-070) administered by continuous Infusion for up to four days to patients with hematological malignancies
-
Schimmer AD, Brandwein J, O'Brien SM, et al. A phase I trial of the small molecule pan-Bcl-2 family inhibitor obatoclax mesylate (GX15-070) administered by continuous Infusion for up to four days to patients with hematological malignancies. ASH Annual Meeting Abstracts. 2007.
-
(2007)
ASH Annual Meeting Abstracts
-
-
Schimmer, A.D.1
Brandwein, J.2
O'brien, S.M.3
-
105
-
-
84900111456
-
A Phase II trial of the small molecule Pan-Bcl-2 family inhibitor obatoclax mesylate (GX15-070) administered by a 24-h continuous infusion every 2 weeks to patients with chronic idiopathic myelofibrosis (CIMF)
-
Verstovsek S, Raza A, Schimmer AD, Viallet J, Kantarjian H. A Phase II trial of the small molecule Pan-Bcl-2 family inhibitor obatoclax mesylate (GX15-070) administered by a 24-h continuous infusion every 2 weeks to patients with chronic idiopathic myelofibrosis (CIMF). ASH Annual Meeting Abstracts. 2007.
-
(2007)
ASH Annual Meeting Abstracts
-
-
Verstovsek, S.1
Raza, A.2
Schimmer, A.D.3
Viallet, J.4
Kantarjian, H.5
-
106
-
-
40849143771
-
A Phase 1 Trial of the Pan Bcl-2 Family Inhibitor Obatoclax Mesylate (GX15-070) in Combination with Bortezomib in Patients with Relapsed/Refractory Mantle Cell Lymphoma
-
Goy A, Ford P, Feldman T, et al. A Phase 1 Trial of the Pan Bcl-2 Family Inhibitor Obatoclax Mesylate (GX15-070) in Combination with Bortezomib in Patients with Relapsed/Refractory Mantle Cell Lymphoma. ASH Annual Meeting Abstracts. 2007;110:2569.
-
(2007)
ASH Annual Meeting Abstracts
, vol.110
, pp. 2569
-
-
Goy, A.1
Ford, P.2
Feldman, T.3
-
107
-
-
40849144773
-
A Phase i Trial of the Small Molecule Pan-Bcl-2 Family Inhibitor Obatoclax Mesylate (GX15-070) Administered by Continuous Infusion for up to Four Days to Patients with Hematological Malignancies
-
Schimmer AD, Brandwein J, O'Brien SM, et al. A Phase I Trial of the Small Molecule Pan-Bcl-2 Family Inhibitor Obatoclax Mesylate (GX15-070) Administered by Continuous Infusion for up to Four Days to Patients with Hematological Malignancies. ASH Annual Meeting Abstracts. 2007;110:892.
-
(2007)
ASH Annual Meeting Abstracts
, vol.110
, pp. 892
-
-
Schimmer, A.D.1
Brandwein, J.2
O'brien, S.M.3
-
109
-
-
27744524941
-
Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells
-
Thomas M, Gessner A, Vornlocher HP, Hadwiger P, Greil J, Heidenreich O. Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells. Blood. 2005;106:3559-3566.
-
(2005)
Blood
, vol.106
, pp. 3559-3566
-
-
Thomas, M.1
Gessner, A.2
Vornlocher, H.P.3
Hadwiger, P.4
Greil, J.5
Heidenreich, O.6
-
110
-
-
33746843081
-
BH3 peptidomimetics potently activate apoptosis and demonstrate single agent efficacy in neuroblastoma
-
Goldsmith KC, Liu X, Dam V, et al. BH3 peptidomimetics potently activate apoptosis and demonstrate single agent efficacy in neuroblastoma. Oncogene. 2006;25:4525-4533.
-
(2006)
Oncogene
, vol.25
, pp. 4525-4533
-
-
Goldsmith, K.C.1
Liu, X.2
Dam, V.3
-
112
-
-
52449106497
-
Gene expression signatures predictive of early response and outcome in high-risk childhood acute lymphoblastic leukemia: A Children's Oncology Group Study [corrected]
-
Bhojwani D, Kang H, Menezes RX, et al. Gene expression signatures predictive of early response and outcome in high-risk childhood acute lymphoblastic leukemia: A Children's Oncology Group Study [corrected]. J Clin Oncol. 2008;26:4376-4384.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4376-4384
-
-
Bhojwani, D.1
Kang, H.2
Menezes, R.X.3
-
113
-
-
34548013784
-
A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia
-
Flotho C, Coustan-Smith E, Pei D, et al. A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia. Blood. 2007;110:1271-1277.
-
(2007)
Blood
, vol.110
, pp. 1271-1277
-
-
Flotho, C.1
Coustan-Smith, E.2
Pei, D.3
-
114
-
-
30444446961
-
The expression of 70 apoptosis genes in relation to lineage, genetic subtype, cellular drug resistance, and outcome in childhood acute lymphoblastic leukemia
-
Holleman A, den Boer ML, de Menezes RX, et al. The expression of 70 apoptosis genes in relation to lineage, genetic subtype, cellular drug resistance, and outcome in childhood acute lymphoblastic leukemia. Blood. 2006;107:769-776.
-
(2006)
Blood
, vol.107
, pp. 769-776
-
-
Holleman, A.1
Den Boer, M.L.2
De Menezes, R.X.3
-
115
-
-
77953020928
-
The bh3-mimetic obatoclax restores the response to dexamethasone in glucocorticoid-resistant all through induction of autophagy
-
Bonapace L, Bornhauser BC, Cario G, et al. The BH3-Mimetic Obatoclax Restores the Response to Dexamethasone in Glucocorticoid-Resistant ALL through Induction of Autophagy. ASH Annual Meeting Abstracts. 2007;110:806.
-
(2007)
ASH Annual Meeting Abstracts
, vol.110
, pp. 806
-
-
Bonapace, L.1
Bornhauser, B.C.2
Cario, G.3
-
116
-
-
33750834023
-
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
-
van Delft MF, Wei AH, Mason KD, et al. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell. 2006;10:389-399.
-
(2006)
Cancer Cell
, vol.10
, pp. 389-399
-
-
Van Delft, M.F.1
Wei, A.H.2
Mason, K.D.3
-
117
-
-
84894902159
-
Pan-Anti-apoptotic bcl-2 family inhibitor, obatoclax, activates autophagic cell death pathway and has potent cytotoxicity in infant and pediatric mll-rearranged leukemias
-
Zhang AY, Robinson BW, Wang L-S, et al. Pan-Anti-Apoptotic BCL-2 Family Inhibitor, Obatoclax, Activates Autophagic Cell Death Pathway and Has Potent Cytotoxicity in Infant and Pediatric MLL-Rearranged Leukemias. ASH Annual Meeting Abstracts. 2008;112:2647.
-
(2008)
ASH Annual Meeting Abstracts
, vol.112
, pp. 2647
-
-
Zhang, A.Y.1
Robinson, B.W.2
Wang, L.-S.3
-
118
-
-
38949108670
-
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
-
Klionsky DJ, Abeliovich H, Agostinis P, et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008;4:151-175.
-
(2008)
Autophagy
, vol.4
, pp. 151-175
-
-
Klionsky, D.J.1
Abeliovich, H.2
Agostinis, P.3
-
119
-
-
34248998801
-
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
-
Maiuri MC, Le Toumelin G, Criollo A, et al. Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. Embo J. 2007;26:2527-2539.
-
(2007)
Embo J.
, vol.26
, pp. 2527-2539
-
-
Maiuri, M.C.1
Le Toumelin, G.2
Criollo, A.3
-
120
-
-
84900263985
-
Obatoclax biodistribution in mll leukemia nog mouse model is predicted by modeling and simulation and shows high tissue penetration at clinically important sites
-
Zhang AY, Barrett JS, Danet-Desnoyers G, et al. Obatoclax Biodistribution in MLL leukemia NOG Mouse Model is predicted by modeling and simulation and shows high tissue penetration at clinically important sites. J Clin Pharmacol. 2008;48:1130.
-
(2008)
J Clin Pharmacol
, vol.48
, pp. 1130
-
-
Zhang, A.Y.1
Barrett, J.S.2
Danet-Desnoyers, G.3
-
121
-
-
84900171700
-
Modeling and simulation approach to advance molecularly-targeted pro-apoptotic agents for infant leukemias
-
Zhang AY, Barrett JS, Beauparlant P, et al. Modeling and Simulation Approach to Advance Molecularly-Targeted Pro-Apoptotic Agents for Infant Leukemias. J Clin Pharmacol. 2007;47:1209.
-
(2007)
J Clin Pharmacol
, vol.47
, pp. 1209
-
-
Zhang, A.Y.1
Barrett, J.S.2
Beauparlant, P.3
-
122
-
-
34548814971
-
Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo
-
Kang MH, Kang YH, Szymanska B, et al. Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo. Blood. 2007.
-
(2007)
Blood
-
-
Kang, M.H.1
Kang, Y.H.2
Szymanska, B.3
-
123
-
-
33846884216
-
The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan
-
Trudel S, Stewart AK, Li Z, et al. The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan. Clin Cancer Res. 2007;13:621-629.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 621-629
-
-
Trudel, S.1
Stewart, A.K.2
Li, Z.3
-
124
-
-
34147142477
-
A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma
-
Chauhan D, Velankar M, Brahmandam M, et al. A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma. Oncogene. 2007;26:2374-2380.
-
(2007)
Oncogene
, vol.26
, pp. 2374-2380
-
-
Chauhan, D.1
Velankar, M.2
Brahmandam, M.3
-
125
-
-
33750628289
-
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
-
Konopleva M, Contractor R, Tsao T, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell. 2006;10:375-388.
-
(2006)
Cancer Cell
, vol.10
, pp. 375-388
-
-
Konopleva, M.1
Contractor, R.2
Tsao, T.3
-
126
-
-
34250770481
-
ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells
-
Kline MP, Rajkumar SV, Timm MM, et al. ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells. Leukemia. 2007;21:1549-1560.
-
(2007)
Leukemia
, vol.21
, pp. 1549-1560
-
-
Kline, M.P.1
Rajkumar, S.V.2
Timm, M.M.3
-
127
-
-
33845421171
-
Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML
-
Kojima K, Konopleva M, Samudio IJ, Schober WD, Bornmann WG, Andreeff M. Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML. Cell Cycle. 2006;5:2778-2786.
-
(2006)
Cell Cycle
, vol.5
, pp. 2778-2786
-
-
Kojima, K.1
Konopleva, M.2
Samudio, I.J.3
Schober, W.D.4
Bornmann, W.G.5
Andreeff, M.6
-
128
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
Oltersdorf T, Elmore SW, Shoemaker AR, et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature. 2005;435:677-681.
-
(2005)
Nature
, vol.435
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
-
129
-
-
0013312329
-
Inhibition of FLT3 in MLL Validation of a therapeutic target identified by gene expression based classification
-
Armstrong SA, Kung AL, Mabon ME, et al. Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. Cancer Cell. 2003;3:173-183.
-
(2003)
Cancer Cell
, vol.3
, pp. 173-183
-
-
Armstrong, S.A.1
Kung, A.L.2
Mabon, M.E.3
-
130
-
-
33746149660
-
Combinations of the FLT3 inhibitor CEP-701 and chemotherapy synergistically kill infant and childhood MLL-rearranged ALL cells in a sequence-dependent manner
-
Brown P, Levis M, McIntyre E, Griesemer M, Small D. Combinations of the FLT3 inhibitor CEP-701 and chemotherapy synergistically kill infant and childhood MLL-rearranged ALL cells in a sequence-dependent manner. Leukemia. 2006;20:1368-1376.
-
(2006)
Leukemia
, vol.20
, pp. 1368-1376
-
-
Brown, P.1
Levis, M.2
McIntyre, E.3
Griesemer, M.4
Small, D.5
-
131
-
-
1542269168
-
FLT3 inhibitors: A paradigm for the development of targeted therapeutics for paediatric cancer
-
discussion 722-704
-
Brown P, Small D. FLT3 inhibitors: a paradigm for the development of targeted therapeutics for paediatric cancer. Eur J Cancer. 2004;40:707-721, discussion 722-704.
-
(2004)
Eur J Cancer
, vol.40
, pp. 707-721
-
-
Brown, P.1
Small, D.2
-
132
-
-
27144499798
-
Targeting FLT3 in primary MLL gene rearranged infant acute lymphoblastic leukemia
-
Stam RW, den Boer ML, Schneider P, et al. Targeting FLT3 in primary MLL gene rearranged infant acute lymphoblastic leukemia. Blood. 2005.
-
(2005)
Blood
-
-
Stam, R.W.1
Den Boer, M.L.2
Schneider, P.3
-
133
-
-
34447523378
-
FLT3 as a therapeutic target in childhood acute leukemia
-
Stubbs MC, Armstrong SA. FLT3 as a therapeutic target in childhood acute leukemia. Curr Drug Targets. 2007;8:703-714.
-
(2007)
Curr Drug Targets
, vol.8
, pp. 703-714
-
-
Stubbs, M.C.1
Armstrong, S.A.2
-
134
-
-
33750013392
-
A high-throughput, fully automated liquid/liquid extraction liquid chromatography/mass spectrometry method for the quantitation of a new investigational drug ABT-869 and its metabolite A-849529 in human plasma samples
-
Rodila RC, Kim JC, Ji QC, El-Shourbagy TA. A high-throughput, fully automated liquid/liquid extraction liquid chromatography/mass spectrometry method for the quantitation of a new investigational drug ABT-869 and its metabolite A-849529 in human plasma samples. Rapid Commun Mass Spectrom. 2006;20:3067-3075.
-
(2006)
Rapid Commun Mass Spectrom
, vol.20
, pp. 3067-3075
-
-
Rodila, R.C.1
Kim, J.C.2
Ji, Q.C.3
El-Shourbagy, T.A.4
-
135
-
-
29244453923
-
Targeting the unmet medical need: The Abbott Laboratories oncology approach
-
Carlson DM, Steinberg JL, Gordon G. Targeting the unmet medical need: the Abbott Laboratories oncology approach. Clin Adv Hematol Oncol. 2005;3:703-710.
-
(2005)
Clin Adv Hematol Oncol
, vol.3
, pp. 703-710
-
-
Carlson, D.M.1
Steinberg, J.L.2
Gordon, G.3
-
136
-
-
34147137124
-
Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N-(2-fluoro-5- methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor
-
Dai Y, Hartandi K, Ji Z, et al. Discovery of N-(4-(3-amino-1H-indazol-4- yl)phenyl)-N-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor. J Med Chem. 2007;50:1584-1597.
-
(2007)
J Med Chem
, vol.50
, pp. 1584-1597
-
-
Dai, Y.1
Hartandi, K.2
Ji, Z.3
-
137
-
-
34147102941
-
ABT-869, a multitargeted receptor tyrosine kinase inhibitor: Inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia
-
Shankar DB, Li J, Tapang P, et al. ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia. Blood. 2007;109: 3400-3408.
-
(2007)
Blood
, vol.109
, pp. 3400-3408
-
-
Shankar, D.B.1
Li, J.2
Tapang, P.3
-
138
-
-
33646586669
-
Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor
-
Albert DH, Tapang P, Magoc TJ, et al. Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol Cancer Ther. 2006;5:995-1006.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 995-1006
-
-
Albert, D.H.1
Tapang, P.2
Magoc, T.J.3
-
139
-
-
33846936758
-
Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways
-
Piloto O, Wright M, Brown P, Kim KT, Levis M, Small D. Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways. Blood. 2007;109:1643-1652.
-
(2007)
Blood
, vol.109
, pp. 1643-1652
-
-
Piloto, O.1
Wright, M.2
Brown, P.3
Kim, K.T.4
Levis, M.5
Small, D.6
-
140
-
-
34447642522
-
BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts
-
Kohl TM, Hellinger C, Ahmed F, et al. BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts. Leukemia. 2007.
-
(2007)
Leukemia
-
-
Kohl, T.M.1
Hellinger, C.2
Ahmed, F.3
-
141
-
-
0035158486
-
Targeted down-regulation of MLL-AF9 with antisense oligodeoxyribonucleotide reduces the expression of the HOXA7 and-A10 genes and induces apoptosis in a human leukemia cell line, THP-1
-
Kawagoe H, Kawagoe R, Sano K. Targeted down-regulation of MLL-AF9 with antisense oligodeoxyribonucleotide reduces the expression of the HOXA7 and-A10 genes and induces apoptosis in a human leukemia cell line, THP-1. Leukemia. 2001;15:1743-1749.
-
(2001)
Leukemia
, vol.15
, pp. 1743-1749
-
-
Kawagoe, H.1
Kawagoe, R.2
Sano, K.3
-
142
-
-
0035905747
-
Downregulation of MLL-CBP fusion gene expression is associated with differentiation of SN-1 cells with t(11;16)(q23;p13)
-
Niitsu N, Hayashi Y, Honma Y. Downregulation of MLL-CBP fusion gene expression is associated with differentiation of SN-1 cells with t(11;16)(q23;p13). Oncogene. 2001;20:375-384.
-
(2001)
Oncogene
, vol.20
, pp. 375-384
-
-
Niitsu, N.1
Hayashi, Y.2
Honma, Y.3
-
143
-
-
0032170873
-
Antisense oligodeoxyribonucleotide against the MLL-LTG19 chimeric transcript inhibits cell growth and induces apoptosis in cells of an infantile leukemia cell line carrying the t(11;19) chromosomal translocation
-
Akao Y, Mizoguchi H, Misiura K, et al. Antisense oligodeoxyribonucleotide against the MLL-LTG19 chimeric transcript inhibits cell growth and induces apoptosis in cells of an infantile leukemia cell line carrying the t(11;19) chromosomal translocation. Cancer Res. 1998;58:3773-3776.
-
(1998)
Cancer Res
, vol.58
, pp. 3773-3776
-
-
Akao, Y.1
Mizoguchi, H.2
Misiura, K.3
-
144
-
-
33846522525
-
The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling
-
Bitoun E, Oliver PL, Davies KE. The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling. Hum Mol Genet. 2007;16:92-106.
-
(2007)
Hum Mol Genet
, vol.16
, pp. 92-106
-
-
Bitoun, E.1
Oliver, P.L.2
Davies, K.E.3
-
145
-
-
4344621639
-
The synthetic peptide PFWT disrupts AF4-AF9 protein complexes and induces apoptosis in t(4;11) leukemia cells
-
Srinivasan RS, Nesbit JB, Marrero L, Erfurth F, LaRussa VF, Hemenway CS. The synthetic peptide PFWT disrupts AF4-AF9 protein complexes and induces apoptosis in t(4;11) leukemia cells. Leukemia. 2004;18:1364-1372.
-
(2004)
Leukemia
, vol.18
, pp. 1364-1372
-
-
Srinivasan, R.S.1
Nesbit, J.B.2
Marrero, L.3
Erfurth, F.4
Larussa, V.F.5
Hemenway, C.S.6
-
147
-
-
39049117344
-
The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells
-
Palermo CM, Bennett CA, Winters AC, Hemenway CS. The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells. Leuk Res. 2008;32:633-642.
-
(2008)
Leuk Res
, vol.32
, pp. 633-642
-
-
Palermo, C.M.1
Bennett, C.A.2
Winters, A.C.3
Hemenway, C.S.4
-
148
-
-
67349158014
-
Molecular targeting of MLL-rearranged leukemia cell lines with the synthetic peptide PFWT synergistically enhances the cytotoxic effect of established chemotherapeutic agents
-
Bennett CA, Winters AC, Barretto NN, Hemenway CS. Molecular targeting of MLL-rearranged leukemia cell lines with the synthetic peptide PFWT synergistically enhances the cytotoxic effect of established chemotherapeutic agents. Leuk Res. 2009;33:937-947.
-
(2009)
Leuk Res
, vol.33
, pp. 937-947
-
-
Bennett, C.A.1
Winters, A.C.2
Barretto, N.N.3
Hemenway, C.S.4
-
149
-
-
55249120170
-
Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy
-
Wang Z, Smith KS, Murphy M, Piloto O, Somervaille TC, Cleary ML. Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy. Nature. 2008;455:1205-1209.
-
(2008)
Nature
, vol.455
, pp. 1205-1209
-
-
Wang, Z.1
Smith, K.S.2
Murphy, M.3
Piloto, O.4
Somervaille, T.C.5
Cleary, M.L.6
-
151
-
-
0031005361
-
Crystal structure of an Hsp90-geldanamycin complex: Targeting of a protein chaperone by an antitumor agent
-
Stebbins CE, Russo AA, Schneider C, Rosen N, Hartl FU, Pavletich NP. Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent. Cell. 1997;89:239-250.
-
(1997)
Cell
, vol.89
, pp. 239-250
-
-
Stebbins, C.E.1
Russo, A.A.2
Schneider, C.3
Rosen, N.4
Hartl, F.U.5
Pavletich, N.P.6
-
152
-
-
20444371377
-
Constantly updated knowledge of Hsp90
-
Terasawa K, Minami M, Minami Y. Constantly updated knowledge of Hsp90. J Biochem. 2005;137:443-447.
-
(2005)
J Biochem
, vol.137
, pp. 443-447
-
-
Terasawa, K.1
Minami, M.2
Minami, Y.3
-
153
-
-
0042313977
-
The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasome
-
Imai J, Maruya M, Yashiroda H, Yahara I, Tanaka K. The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasome. EMBO J. 2003;22:3557-3567.
-
(2003)
EMBO J.
, vol.22
, pp. 3557-3567
-
-
Imai, J.1
Maruya, M.2
Yashiroda, H.3
Yahara, I.4
Tanaka, K.5
-
154
-
-
0141925960
-
FLT3 expressing leukemias are selectively sensitive to inhibitors of the molecular chaperone heat shock protein 90 through destabilization of signal transduction-associated kinases
-
Yao Q, Nishiuchi R, Li Q, Kumar AR, Hudson WA, Kersey JH. FLT3 expressing leukemias are selectively sensitive to inhibitors of the molecular chaperone heat shock protein 90 through destabilization of signal transduction-associated kinases. Clin Cancer Res. 2003;9:4483-4493.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 4483-4493
-
-
Yao, Q.1
Nishiuchi, R.2
Li, Q.3
Kumar, A.R.4
Hudson, W.A.5
Kersey, J.H.6
-
155
-
-
49649095676
-
Hsp90 regulates the phosphorylation and activity of serum-and glucocorticoid-regulated kinase-1
-
Belova L, Brickley DR, Ky B, Sharma SK, Conzen SD. Hsp90 regulates the phosphorylation and activity of serum-and glucocorticoid-regulated kinase-1. J Biol Chem. 2008;283:18821-18831.
-
(2008)
J Biol Chem
, vol.283
, pp. 18821-18831
-
-
Belova, L.1
Brickley, D.R.2
Ky, B.3
Sharma, S.K.4
Conzen, S.D.5
-
156
-
-
0037155901
-
Involvement of Hsp90 in signaling and stability of 3-phosphoinositide- dependent kinase-1
-
Fujita N, Sato S, Ishida A, Tsuruo T. Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2002;277:10346-10353.
-
(2002)
J Biol Chem
, vol.277
, pp. 10346-10353
-
-
Fujita, N.1
Sato, S.2
Ishida, A.3
Tsuruo, T.4
-
157
-
-
20544446881
-
Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis
-
Zhang R, Luo D, Miao R, et al. Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis. Oncogene. 2005;24:3954-3963.
-
(2005)
Oncogene
, vol.24
, pp. 3954-3963
-
-
Zhang, R.1
Luo, D.2
Miao, R.3
-
158
-
-
2942731290
-
Hsp90 invades the outside
-
Picard D. Hsp90 invades the outside. Nat Cell Biol. 2004;6:479-480.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 479-480
-
-
Picard, D.1
-
159
-
-
11344280957
-
Extracellular roles for the molecular chaperone, hsp90
-
Eustace BK, Jay DG. Extracellular roles for the molecular chaperone, hsp90. Cell Cycle. 2004;3:1098-1100.
-
(2004)
Cell Cycle
, vol.3
, pp. 1098-1100
-
-
Eustace, B.K.1
Jay, D.G.2
-
160
-
-
2942716692
-
Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness
-
Eustace BK, Sakurai T, Stewart JK, et al. Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness. Nat Cell Biol. 2004;6:507-514.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 507-514
-
-
Eustace, B.K.1
Sakurai, T.2
Stewart, J.K.3
-
161
-
-
33750106379
-
Proteomics-based strategy to identify biomarkers and pharmacological targets in leukemias with t(4;11) translocations
-
Yocum AK, Busch CM, Felix CA, Blair IA. Proteomics-based strategy to identify biomarkers and pharmacological targets in leukemias with t(4;11) translocations. J Proteome Res. 2006;5:2743-2753.
-
(2006)
J Proteome Res
, vol.5
, pp. 2743-2753
-
-
Yocum, A.K.1
Busch, C.M.2
Felix, C.A.3
Blair, I.A.4
-
162
-
-
33947386313
-
Synergism between etoposide and 17-AAG in leukemia cells: Critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51
-
Yao Q, Weigel B, Kersey J. Synergism between etoposide and 17-AAG in leukemia cells: critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51. Clin Cancer Res. 2007;13:1591-1600.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1591-1600
-
-
Yao, Q.1
Weigel, B.2
Kersey, J.3
-
163
-
-
26944483583
-
Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: The key role of the STAT5 signal transduction pathway
-
Yao Q, Nishiuchi R, Kitamura T, Kersey JH. Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: the key role of the STAT5 signal transduction pathway. Leukemia. 2005;19:1605-1612.
-
(2005)
Leukemia
, vol.19
, pp. 1605-1612
-
-
Yao, Q.1
Nishiuchi, R.2
Kitamura, T.3
Kersey, J.H.4
-
164
-
-
33745184273
-
G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent
-
Tonelli R, Sartini R, Fronza R, et al. G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent. Leukemia. 2006;20:1307-1310.
-
(2006)
Leukemia
, vol.20
, pp. 1307-1310
-
-
Tonelli, R.1
Sartini, R.2
Fronza, R.3
-
165
-
-
0035124606
-
Sensitization by 5-aza-2-deoxycytidine of leukaemia cells with MLL abnormalities to induction of differentiation by all-trans retinoic acid and 1alpha,25-dihydroxyvitamin D3
-
Niitsu N, Hayashi Y, Sugita K, Honma Y. Sensitization by 5-aza-2-deoxycytidine of leukaemia cells with MLL abnormalities to induction of differentiation by all-trans retinoic acid and 1alpha,25-dihydroxyvitamin D3. Br J Haematol. 2001;112:315-326.
-
(2001)
Br J Haematol
, vol.112
, pp. 315-326
-
-
Niitsu, N.1
Hayashi, Y.2
Sugita, K.3
Honma, Y.4
-
166
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renalcell carcinoma
-
Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renalcell carcinoma. N Engl J Med. 2007;356:2271-2281.
-
(2007)
N Engl J Med
, vol.356
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
-
167
-
-
0345166113
-
Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling
-
Brown VI, Fang J, Alcorn K, et al. Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by
-
(2003)
Proc Natl Acad Sci U S A.
, vol.100
, pp. 15113-15118
-
-
Brown, V.I.1
Fang, J.2
Alcorn, K.3
-
168
-
-
52649149525
-
MTOR inhibitors are synergistic with methotrexate: An effective combination to treat acute lymphoblastic leukemia
-
Teachey DT, Sheen C, Hall J, et al. mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia. Blood. 2008;112:2020-2023.
-
(2008)
Blood
, vol.112
, pp. 2020-2023
-
-
Teachey, D.T.1
Sheen, C.2
Hall, J.3
-
169
-
-
33749443714
-
Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance
-
Wei G, Twomey D, Lamb J, et al. Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. Cancer Cell. 2006;10:331-342.
-
(2006)
Cancer Cell
, vol.10
, pp. 331-342
-
-
Wei, G.1
Twomey, D.2
Lamb, J.3
-
170
-
-
0031717981
-
Relation between age, immunophenotype and in vitro drug resistance in 395 children with acute lymphoblastic leukemia-implications for treatment of infants
-
Pieters R, den Boer ML, Durian M, et al. Relation between age, immunophenotype and in vitro drug resistance in 395 children with acute lymphoblastic leukemia-implications for treatment of infants. Leukemia. 1998;12:1344-1348.
-
(1998)
Leukemia
, vol.12
, pp. 1344-1348
-
-
Pieters, R.1
Den Boer, M.L.2
Durian, M.3
-
171
-
-
20244380336
-
Cellular drug sensitivity in MLL-rearranged childhood acute leukaemia is correlated to partner genes and cell lineage
-
Palle J, Frost BM, Forestier E, et al. Cellular drug sensitivity in MLL-rearranged childhood acute leukaemia is correlated to partner genes and cell lineage. Br J Haematol. 2005;129:189-198.
-
(2005)
Br J Haematol
, vol.129
, pp. 189-198
-
-
Palle, J.1
Frost, B.M.2
Forestier, E.3
-
172
-
-
0038495925
-
Gemtuzumab ozogamicin: First clinical experiences in children with relapsed/refractory acute myeloid leukemia treated on compassionate-use basis
-
Zwaan CM, Reinhardt D, Corbacioglu S, et al. Gemtuzumab ozogamicin: first clinical experiences in children with relapsed/refractory acute myeloid leukemia treated on compassionate-use basis. Blood. 2003;101:3868-3871.
-
(2003)
Blood
, vol.101
, pp. 3868-3871
-
-
Zwaan, C.M.1
Reinhardt, D.2
Corbacioglu, S.3
-
173
-
-
23744511263
-
Safety and efficacy of gemtuzumab ozogamicin in pediatric patients with advanced CD33+ acute myeloid leukemia
-
Arceci RJ, Sande J, Lange B, et al. Safety and efficacy of gemtuzumab ozogamicin in pediatric patients with advanced CD33+ acute myeloid leukemia. Blood. 2005;106:1183-1188.
-
(2005)
Blood
, vol.106
, pp. 1183-1188
-
-
Arceci, R.J.1
Sande, J.2
Lange, B.3
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