Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias

Blood

Volumn 87, Issue 3, 1996, Pages 1089-1096

  Carow, Catherine E ^b   Levenstein, Mark ^b   Kaufmann, Scott H ^b   Chen, Joseph ^b   Amin, Shahina ^b   Rockwell, Patricia ^b   Witte, Larry ^b   Borowitz, Michael J ^b   Civin, Curt I ^b   Small, Donald ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; GROWTH FACTOR RECEPTOR; HEMOPOIETIC GROWTH FACTOR; RECEPTOR PROTEIN; RNA;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOCYTIC LEUKEMIA; ARTICLE; AUTOPHOSPHORYLATION; BLAST CELL; BONE MARROW; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; MONONUCLEAR CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 13344282746     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.3.1089.bloodjournal8731089     Document Type: Article

References (39)

1. Ogawa M, Porter PN, Nakahata T: Renewal and commitment to differentiation of hemtopoietic stem cells: An interpretive review. Blood 61:823, 1983
2. Ogawa M: Differentiation and proliferation of hematopoietic stem cells. Blood 81:2844, 1993
3. Ullrich A, Schlessinger J: Signal transduction by receptors with tyrosine kinase activity. Cell 61:203, 1990
4. + human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Acad Sci USA 91:459, 1994
5. Matthews W, Jordan CT, Wiegand GW, Pardoll D, Lemischka IR: A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell 65:1143, 1991
6. Rosnet O, Schiff C, Pebusque M-J, Marchetto S, Tonnelle C, Toiron Y, Birg F, Birnbaum D. Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells Blood 82:1110, 1993
7. Rosnet O, Marchetto S, DeLapeyriere O, Birnbaum D: Munne FLT3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family. Oncogene 6:1641, 1991
8. Lyman S, James L, Vanden Bos T, de Vries P, Brasel K, Gliiniak B, Hollingsworth L, Picha K, McKenna H, Splett R, Fletcher F, Maraskovsky E, Farrah T, Foxworth D, Williams D, Beckmann P: Molecular Cloning of a Ligand for the flt3/flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells. Cell 75:1157, 1993
9. Lyman SD, James L, Johnson L, Brasel K, de Vries P, Escobar SS, Downey H, Splett RR, Beckmann MP, McKenna HJ: Cloning of the human homologue of the murine flt3 ligand: A growth factor for early hematopoietic progenitor cells. Blood 83:2795, 1994
10. Hannum C, Culpepper J, Campbell D, McClanahan T, Zurawski S, Bazan JF, Kastelein R, Hudak S, Wagner J, Mattson J, Luh J, Duda G, Martina N, Peterson D, Menon S, Shanafelt A, Muench M, Keiner G, Namikawa R, Rennick D, Roncarolo MG, Zlotnik A, Rosnet O, Dubreuil P, Birnbaum D, Lee F: Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. Nature 368:643, 1994
11. Hudak S, Hunte B, Culpepper J, Menon S, Hannum C, Thompson-Snipes L, Rennick D: FLT3/FLK2 ligand promotes the growth of murine stem cells and the expansion of colony-forming cells and spleen colony-forming units. Blood 85:2747, 1995
12. Ikeda H, Kanakura Y, Tamaki T, Kuriu A, Katayama H, Ishikawa J, Kanayama Y, Yonezawa T, Tarui S, Griffin JD: Expression and functional role of the protooncogene c-kit in acute myeloblastic leukemia cells. Blood 78:2962, 1991
13. Kanakura Y, Ikeda H, Kitayama H, Sugahara H, Furitsu T: Expression, function and activation of the proto-oncogene c-kit product in human leukemia cells. Leuk Lymphoma 10:35, 1993
14. Gadd SJ, Ashman LK: A murine monoclonal antibody specific for a cell-surface antigen expressed by a sub-group of human myeloid leukaemias. Leuk Res 9:1329, 1985
15. Broudy VC, Smith FO, Lin N, Zsebo KM, Egrie J, Bernstein ID: Blasts from patients with acute myelogenous leukemia express functional receptors for stem cell factor. Blood 80:60, 1992
16. Wang CC, JE, Giessler EN, McCulloch EA, Minden MD: The expression of the proto-oncogene c-kit in the blast cells of acute myeloblastic leukemia. Leukemia 3:699, 1989
17. Reuss-Borst MA, Buhring HJ, Schmidt H, Muller CA: AML: Immunophenotypic heterogeneity and prognostic significance of immunophenotypic heterogeneity and prognostic significance of c-kit expression. Leukemia 8:258, 1994
18. Torres H, Dubrueil P, Falzetti F, Courcoul M, Lopez M, Falcinelii F, Birg F, Tabilio A, Mannoni P: c-fms expression in acute leukemias with complex phenotypes. Leukemia 4:673, 1990
19. Parwaresch MR, Kriepe H, Feigner J, Heidorn K, Jaquet K, Bodewadt-Radzun S, Radzun HJ: M-CSF and M-CSF receptor gene expression in acute myelomonocytic leukemias. Leuk Res 14:27, 1990
20. Dubreuil P, Torres H, Courcoul M-A, Birg F, Mannoni P: c-fins expression is a molecular marker of human acute myeloid leukemias. Blood 72:1081, 1988
21. Rambaldi A, Wakamiya N, Vellenga E, Horiguchi J, Warren MK, Kufe D, Griffin JD: Expression of the macrophage colony-stimulating factor and c-fins genes in human acute myeloblastic leukemia cells. J Clin Invest 81:1030, 1988
22. Ashmun RA, Look T, Roberts WM, Roussel MF, Seremitis S, Ohtsuka M, Sherr CJ: Monoclonal antibodies to the human CSF 1 receptor (c-fms proto-oncogene product) detect epitopes on normal mononuclear phagocytes and on human myeloid leukemic blast cells. Blood 73:827, 1989
23. Priesler HD, Raza A, Larson R, LeBeau M, Browman G, Goldberg J, Grunwald H, Vogler R, Verkh L, Singh P, Block AM, Sandberg A: Protooncogene expression and the clinical characteristics of acute nonlymphocytic leukemia: A leukemia intergroup study. Blood 73:255, 1989
24. Duttlinger R, Manova K, Chu T, Gyssler C, Zelenetz A, Bacharova R, Besmer P: W-sash affects positive and negative elements controlling c-kit expression: Ectopic c-kit expression at sites of kit ligand expression affects melanogenesis. Development 118:705, 1993
25. Pietsch T, Kyas U, Yakisan L, Hadam M, Ludwig W, Zsebo K, Welte K: Effects of human stem cell factor (c-kit ligand) on proliferation of myeloid leukemia cells: Heterogeneity in response and synergy with other hematopoietic growth factors. Blood 80:1199, 1992
26. Toyota M, Hinoda Y, Takaoka A, Makiguchi Y, Takahashi T, Itoh F, Imai K, Yachi A: Expression of c-kit and kit ligand in human colon carcinoma cells. Tumour Biol 14:295, 1993
27. Kitayama H, Kanakura Y, Furitsu T, Tsujimura T, Oritani K, Ikeda H, Sugahra H, Mitsui H, Kanayama Y, Kitamura Y, Matsuzawa Y: Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines. Blood 85:790, 1995
28. Ridge SA, Worwood M, Oscier D, Jacobs A, Padua RA: FMS mutations in myelodysplastic, leukemic, and normal subjects. Proc Natl Acad Sci USA 87:1377, 1990
29. Birg F, Courcoul M, Rosnet O, Bardin F, Pebusque M, Marchetto S, Tabilio A, Mannoni P, Birnbaum D: Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages. Blood 80:2584, 1992
30. Hwong CL, Chen C-Y, Shang H-F, Hwang J: Increased synthesis and degredation of DNA topoisomerase I during the initial phase of human T lymphocyte proliferation. J Biol Chem 268:18982, 1993
31. Kaufmann SH, Charron M, Burke PJ, Karp JE: Topoisomerase I levels and subnuclear localization during myeloid maturation in vitro and in vivo. Cancer Res 55:1255, 1995
32. Civin C: Human Monomyeloid Cell Membrane Antigens. Exp Hematol 18:461, 1990
33. Civin CI, Strauss LC, Fackler MJ, Trischmann TM, Wiley JM, Loken MR: Positive stem cell selection: Basic science, in Gross S, Gee A, Worthington-White D (eds): Bone Marrow Purging & Processing. New York, NY, Liss 1990, p 387
34. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyante-phenol-chloroform extraction. Anal Biochem 162:156, 1987
35. Melton DA, Krieg PA, Rebagliati MR, Maniatis T, Zinn K, Green MR: Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res 12:7035, 1984
36. Kaufmann SH, Karp JE, Jones RJ, Miller CB, Schneider E: Topoisomerase II levels and drug sensitivity in adult acute myelogenous leukemia. Blood 83:517, 1994
37. Kaufmann SH, Shaper JH: Erasable Western blots. Methods Mol Biol 10:235, 1992
38. 165 with soluble and cell-associated flk-1 receptors. J Biol Chem 269:12456, 1994
39. Zeigler FC, Bennett BD, Jordan CT, Spencer SD, Baumhueter S, Carroll KJ, Hooley J, Bauer K, Matthews W: Cellular and molecular characterization of the role of the FLK-2/FLT-3 receptor tyrosine kinase in hematopoietic stem cells. Blood 84:2422, 1994