메뉴 건너뛰기




Volumn 104, Issue 6, 2004, Pages 1841-1849

Pediatric AML primary samples with FLT3/ITD mutations are preferentially killed by FLT3 inhibition

Author keywords

[No Author keywords available]

Indexed keywords

CEP 701; FLT3 LIGAND; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR;

EID: 4444342401     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-03-1034     Document Type: Article
Times cited : (81)

References (55)
  • 1
    • 0035473994 scopus 로고    scopus 로고
    • Childhood acute lymphoblastic leukaemia - Current status and future perspectives
    • Pui CH, Campana D, Evans WE. Childhood acute lymphoblastic leukaemia - current status and future perspectives. Lancet Oncol. 2001;2:597-607.
    • (2001) Lancet Oncol , vol.2 , pp. 597-607
    • Pui, C.H.1    Campana, D.2    Evans, W.E.3
  • 2
    • 0036675211 scopus 로고    scopus 로고
    • What is the optimal therapy for childhood AML?
    • Loeb DM, Arceci RJ. What is the optimal therapy for childhood AML? Oncology. 2002;16:1057-1066.
    • (2002) Oncology , vol.16 , pp. 1057-1066
    • Loeb, D.M.1    Arceci, R.J.2
  • 3
    • 0036015001 scopus 로고    scopus 로고
    • Progress and controversies in the treatment of pediatric acute myelogenous leukemia
    • Arceci RJ. Progress and controversies in the treatment of pediatric acute myelogenous leukemia. Curr Opin Hematol. 2002;9:353-360.
    • (2002) Curr Opin Hematol , vol.9 , pp. 353-360
    • Arceci, R.J.1
  • 4
    • 1542269168 scopus 로고    scopus 로고
    • FLT3 Inhibitors: A paradigm for the development of targeted therapies for pediatric cancer
    • Brown P, Small D. FLT3 Inhibitors: a paradigm for the development of targeted therapies for pediatric cancer. Eur J Cancer. 2004;40:707-721.
    • (2004) Eur J Cancer , vol.40 , pp. 707-721
    • Brown, P.1    Small, D.2
  • 5
    • 0346258290 scopus 로고    scopus 로고
    • Novel FLT3 tyrosine kinase inhibitors
    • Levis M, Small D. Novel FLT3 tyrosine kinase inhibitors. Expert Opin Investig Drugs. 2003;12:1951-1962.
    • (2003) Expert Opin Investig Drugs , vol.12 , pp. 1951-1962
    • Levis, M.1    Small, D.2
  • 6
    • 0141836914 scopus 로고    scopus 로고
    • FLT3: ITDoes matter in leukemia
    • Levis M, Small D. FLT3: ITDoes matter in leukemia. Leukemia. 2003;17:1738-1752.
    • (2003) Leukemia , vol.17 , pp. 1738-1752
    • Levis, M.1    Small, D.2
  • 7
    • 0036720398 scopus 로고    scopus 로고
    • The roles of FLT3 in hematopoiesis and leukemia
    • Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood. 2002;100:1532-1542.
    • (2002) Blood , vol.100 , pp. 1532-1542
    • Gilliland, D.G.1    Griffin, J.D.2
  • 8
    • 0141465061 scopus 로고    scopus 로고
    • The role of FLT3 in haematopoietic malignancies
    • Stirewalt DL, Radich JP. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer. 2003;3:650-665.
    • (2003) Nat Rev Cancer , vol.3 , pp. 650-665
    • Stirewalt, D.L.1    Radich, J.P.2
  • 9
    • 13344282746 scopus 로고    scopus 로고
    • Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias
    • Carow CE, Levenstein M, Kaufmann SH, et al. Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias. Blood. 1996;87:1089-1096.
    • (1996) Blood , vol.87 , pp. 1089-1096
    • Carow, C.E.1    Levenstein, M.2    Kaufmann, S.H.3
  • 10
    • 9244260192 scopus 로고    scopus 로고
    • Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells
    • Rosnet O, Buhring HJ, Marchetto S, et al. Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells. Leukemia. 1996;10:238-248.
    • (1996) Leukemia , vol.10 , pp. 238-248
    • Rosnet, O.1    Buhring, H.J.2    Marchetto, S.3
  • 11
    • 0026457216 scopus 로고
    • Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages
    • Birg F, Courcoul M, Rosnet O, et al. Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages. Blood. 1992;80:2584-2593.
    • (1992) Blood , vol.80 , pp. 2584-2593
    • Birg, F.1    Courcoul, M.2    Rosnet, O.3
  • 12
    • 9144269029 scopus 로고    scopus 로고
    • FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells
    • Zheng R, Levis M, Piloto O, et al. FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells. Blood. 2004;103:267-274.
    • (2004) Blood , vol.103 , pp. 267-274
    • Zheng, R.1    Levis, M.2    Piloto, O.3
  • 13
    • 0030002950 scopus 로고    scopus 로고
    • Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells
    • Drexler HG. Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells. Leukemia. 1996;10:588-599.
    • (1996) Leukemia , vol.10 , pp. 588-599
    • Drexler, H.G.1
  • 14
    • 0029145627 scopus 로고
    • Expression of FLT3 receptor and FLT3-ligand in human leukemia-lymphoma cell lines
    • Meierhoff G, Dehmel U, Gruss HJ, et al. Expression of FLT3 receptor and FLT3-ligand in human leukemia-lymphoma cell lines. Leukemia. 1995;9:1368-1372.
    • (1995) Leukemia , vol.9 , pp. 1368-1372
    • Meierhoff, G.1    Dehmel, U.2    Gruss, H.J.3
  • 16
    • 0038712179 scopus 로고    scopus 로고
    • Flt3-mediated signaling in human acute myelogenous leukemia (AML) blasts: A functional characterization of Flt3-ligand effects in AML cell populations with and without genetic Flt3 abnormalities
    • Bruserud O, Hovland R, Wergeland L, Huang TS, Gjertsen BT. Flt3-mediated signaling in human acute myelogenous leukemia (AML) blasts: a functional characterization of Flt3-ligand effects in AML cell populations with and without genetic Flt3 abnormalities. Haematologica. 2003;88:416-428.
    • (2003) Haematologica , vol.88 , pp. 416-428
    • Bruserud, O.1    Hovland, R.2    Wergeland, L.3    Huang, T.S.4    Gjertsen, B.T.5
  • 17
    • 0030451722 scopus 로고    scopus 로고
    • Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
    • Nakao M, Yokota S, Iwai T, et al. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia. 1996;10:1911-1918.
    • (1996) Leukemia , vol.10 , pp. 1911-1918
    • Nakao, M.1    Yokota, S.2    Iwai, T.3
  • 18
    • 0035871889 scopus 로고    scopus 로고
    • Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
    • Yamamoto Y, Kiyoi H, Nakano Y, et al. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood. 2001;97:2434-2439.
    • (2001) Blood , vol.97 , pp. 2434-2439
    • Yamamoto, Y.1    Kiyoi, H.2    Nakano, Y.3
  • 20
    • 0031883328 scopus 로고    scopus 로고
    • FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates
    • Lavagna-Sevenier C, Marchetto S, Birnbaum D, Rosnet O. FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates. Leukemia. 1998;12:301-310.
    • (1998) Leukemia , vol.12 , pp. 301-310
    • Lavagna-Sevenier, C.1    Marchetto, S.2    Birnbaum, D.3    Rosnet, O.4
  • 21
    • 0034649210 scopus 로고    scopus 로고
    • Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase
    • Zhang S, Broxmeyer HE. Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase. Biochem Biophys Res Commun. 2000;277:195-199.
    • (2000) Biochem Biophys Res Commun , vol.277 , pp. 195-199
    • Zhang, S.1    Broxmeyer, H.E.2
  • 22
    • 0033020705 scopus 로고    scopus 로고
    • Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells
    • Zhang S, Mantel C, Broxmeyer HE. Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells. J Leukoc Biol. 1999;65:372-380.
    • (1999) J Leukoc Biol , vol.65 , pp. 372-380
    • Zhang, S.1    Mantel, C.2    Broxmeyer, H.E.3
  • 23
    • 0033582304 scopus 로고    scopus 로고
    • p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells
    • Zhang S, Broxmeyer HE. p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells. Biochem Biophys Res Commun. 1999;254:440-445.
    • (1999) Biochem Biophys Res Commun , vol.254 , pp. 440-445
    • Zhang, S.1    Broxmeyer, H.E.2
  • 24
    • 9044233643 scopus 로고    scopus 로고
    • Expression and signal transduction of the FLT3 tyrosine kinase receptor
    • Rosnet O, Buhring HJ, deLapeyriere O, et al. Expression and signal transduction of the FLT3 tyrosine kinase receptor. Acta Haematol. 1996;95:218-223.
    • (1996) Acta Haematol , vol.95 , pp. 218-223
    • Rosnet, O.1    Buhring, H.J.2    DeLapeyriere, O.3
  • 25
    • 0034605042 scopus 로고    scopus 로고
    • Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling
    • Zhang S, Fukuda S, Lee Y, et al. Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling. J Exp Med. 2000;192:719-728.
    • (2000) J Exp Med , vol.192 , pp. 719-728
    • Zhang, S.1    Fukuda, S.2    Lee, Y.3
  • 26
    • 0031686409 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
    • Kiyoi H, Towatari M, Yokota S, et al. Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia. 1998;12:1333-1337.
    • (1998) Leukemia , vol.12 , pp. 1333-1337
    • Kiyoi, H.1    Towatari, M.2    Yokota, S.3
  • 27
    • 0037061747 scopus 로고    scopus 로고
    • Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain
    • Kiyoi H, Ohno R, Ueda R, Saito H, Naoe T. Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain. Oncogene. 2002;21:2555-2563.
    • (2002) Oncogene , vol.21 , pp. 2555-2563
    • Kiyoi, H.1    Ohno, R.2    Ueda, R.3    Saito, H.4    Naoe, T.5
  • 28
    • 0035168677 scopus 로고    scopus 로고
    • Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia
    • Meshinchi S, Woods WG, Stirewalt DL, et al. Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia. Blood. 2001;97:89-94.
    • (2001) Blood , vol.97 , pp. 89-94
    • Meshinchi, S.1    Woods, W.G.2    Stirewalt, D.L.3
  • 29
    • 0037219507 scopus 로고    scopus 로고
    • FLT3 internal tandem duplication in childhood acute myeloid leukaemia: Association with hyperleucocytosis in acute promyelocytic leukaemia
    • Arrigoni P, Beretta C, Silvestri D, et al. FLT3 internal tandem duplication in childhood acute myeloid leukaemia: association with hyperleucocytosis in acute promyelocytic leukaemia. Br J Haematol. 2003;120:89-92.
    • (2003) Br J Haematol , vol.120 , pp. 89-92
    • Arrigoni, P.1    Beretta, C.2    Silvestri, D.3
  • 30
    • 0037096857 scopus 로고    scopus 로고
    • Clinical relevance of internal tandem duplication of the FLT3 gene in childhood acute myeloid leukemia
    • Liang DC, Shih LY, Hung IJ, et al. Clinical relevance of internal tandem duplication of the FLT3 gene in childhood acute myeloid leukemia. Cancer. 2002;94:3292-3298.
    • (2002) Cancer , vol.94 , pp. 3292-3298
    • Liang, D.C.1    Shih, L.Y.2    Hung, I.J.3
  • 31
    • 0001097136 scopus 로고    scopus 로고
    • Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children
    • Xu F, Taki T, Yang HW, et al. Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children. Br J Haematol. 1999;105:155-162.
    • (1999) Br J Haematol , vol.105 , pp. 155-162
    • Xu, F.1    Taki, T.2    Yang, H.W.3
  • 32
    • 0032757551 scopus 로고    scopus 로고
    • Prognostic value of internal tandem duplication of the FLT3 gene in childhood acute myelogenous leukemia
    • Kondo M, Horibe K, Takahashi Y, et al. Prognostic value of internal tandem duplication of the FLT3 gene in childhood acute myelogenous leukemia. Med Pediatr Oncol. 1999;33:525-529.
    • (1999) Med Pediatr Oncol , vol.33 , pp. 525-529
    • Kondo, M.1    Horibe, K.2    Takahashi, Y.3
  • 33
    • 0032931560 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia
    • The Children's Cancer and Leukemia Study Group, Japan
    • Iwai T, Yokota S, Nakao M, et al. Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia. The Children's Cancer and Leukemia Study Group, Japan. Leukemia. 1999;13:38-43.
    • (1999) Leukemia , vol.13 , pp. 38-43
    • Iwai, T.1    Yokota, S.2    Nakao, M.3
  • 34
    • 0141482006 scopus 로고    scopus 로고
    • FLT3 internal tandem duplication in 234 children with acute myeloid leukemia: Prognostic significance and relation to cellular drug resistance
    • Zwaan CM, Meshinchi S, Radich JP, et al. FLT3 internal tandem duplication in 234 children with acute myeloid leukemia: prognostic significance and relation to cellular drug resistance. Blood. 2003;102:2387-2394.
    • (2003) Blood , vol.102 , pp. 2387-2394
    • Zwaan, C.M.1    Meshinchi, S.2    Radich, J.P.3
  • 35
    • 0041737454 scopus 로고    scopus 로고
    • Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia
    • Meshinchi S, Stirewalt DL, Alonzo TA, et al. Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia. Blood. 2003;102:1474-1479.
    • (2003) Blood , vol.102 , pp. 1474-1479
    • Meshinchi, S.1    Stirewalt, D.L.2    Alonzo, T.A.3
  • 36
    • 0035437140 scopus 로고    scopus 로고
    • A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations
    • Levis M, Tse KF, Smith BD, Garrett E, Small D. A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations. Blood. 2001;98:885-887.
    • (2001) Blood , vol.98 , pp. 885-887
    • Levis, M.1    Tse, K.F.2    Smith, B.D.3    Garrett, E.4    Small, D.5
  • 37
    • 0036624916 scopus 로고    scopus 로고
    • A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo
    • Levis M, Allebach J, Tse KF, et al. A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo. Blood. 2002;99:3885-3891.
    • (2002) Blood , vol.99 , pp. 3885-3891
    • Levis, M.1    Allebach, J.2    Tse, K.F.3
  • 38
    • 0036595143 scopus 로고    scopus 로고
    • Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412
    • Weisberg E, Boulton C, Kelly LM, et al. Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412. Cancer Cell. 2002;1:433-443.
    • (2002) Cancer Cell , vol.1 , pp. 433-443
    • Weisberg, E.1    Boulton, C.2    Kelly, L.M.3
  • 39
    • 0037441745 scopus 로고    scopus 로고
    • The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3
    • Spiekermann K, Dirschinger RJ, Schwab R, et al. The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3. Blood. 2003;101:1494-1504.
    • (2003) Blood , vol.101 , pp. 1494-1504
    • Spiekermann, K.1    Dirschinger, R.J.2    Schwab, R.3
  • 40
    • 0037108298 scopus 로고    scopus 로고
    • SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase
    • Yee KW, O'Farrell AM, Smolich BD, et al. SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase. Blood. 2002;100:2941-2949.
    • (2002) Blood , vol.100 , pp. 2941-2949
    • Yee, K.W.1    O'Farrell, A.M.2    Smolich, B.D.3
  • 41
    • 0038204144 scopus 로고    scopus 로고
    • SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
    • O'Farrell AM, Abrams TJ, Yuen HA, et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood. 2003;101:3597-3605.
    • (2003) Blood , vol.101 , pp. 3597-3605
    • O'Farrell, A.M.1    Abrams, T.J.2    Yuen, H.A.3
  • 42
    • 0013102301 scopus 로고    scopus 로고
    • CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML)
    • Kelly LM, Yu JC, Boulton CL, et al. CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML). Cancer Cell. 2002;1:421-432.
    • (2002) Cancer Cell , vol.1 , pp. 421-432
    • Kelly, L.M.1    Yu, J.C.2    Boulton, C.L.3
  • 43
    • 1842420032 scopus 로고    scopus 로고
    • Single agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia
    • Smith BD, Levis M, Beran M, et al. Single agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia. Blood. 2004;103:3669-3676.
    • (2004) Blood , vol.103 , pp. 3669-3676
    • Smith, B.D.1    Levis, M.2    Beran, M.3
  • 44
    • 1842463109 scopus 로고    scopus 로고
    • A randomized phase II trial of the tyrosine kinase inhibitor PKC412 in patients with acute myeloid leukemia (AML)/high-risk myelodysplastic syndromes (MDS) characterized by wild-type (WT) or mutated FLT3
    • Estey E, Fisher T, Giles F, et al. A randomized phase II trial of the tyrosine kinase inhibitor PKC412 in patients with acute myeloid leukemia (AML)/high-risk myelodysplastic syndromes (MDS) characterized by wild-type (WT) or mutated FLT3 [abstract]. Blood. 2003;102:2270a.
    • (2003) Blood , vol.102
    • Estey, E.1    Fisher, T.2    Giles, F.3
  • 45
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457-481.
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 46
    • 0000957062 scopus 로고
    • Asymptotically efficient rank in variant test procedures
    • Peto R, Peto J. Asymptotically efficient rank in variant test procedures. J R Stat Soc A. 1972;135:185-206.
    • (1972) J R Stat Soc A , vol.135 , pp. 185-206
    • Peto, R.1    Peto, J.2
  • 47
    • 0031884911 scopus 로고    scopus 로고
    • Feasibility, toxicity, and biologic response of interleukin-2 after consolidation chemotherapy for acute myelogenous leukemia: A report from the Children's Cancer Group
    • Sievers EL, Lange BJ, Sondel PM, et al. Feasibility, toxicity, and biologic response of interleukin-2 after consolidation chemotherapy for acute myelogenous leukemia: a report from the Children's Cancer Group. J Clin Oncol. 1998;16:914-919.
    • (1998) J Clin Oncol , vol.16 , pp. 914-919
    • Sievers, E.L.1    Lange, B.J.2    Sondel, P.M.3
  • 48
    • 4444245178 scopus 로고    scopus 로고
    • Pilot study of idarubicin-based intensive-timing induction therapy for children with previously untreated acute myeloid leukemia: Children's Cancer Group Study 2941
    • Lange BJ, Dinndorf P, Smith FO, et al. Pilot study of idarubicin-based intensive-timing induction therapy for children with previously untreated acute myeloid leukemia: Children's Cancer Group Study 2941. J Clin Oncol. 2004;22:150-156.
    • (2004) J Clin Oncol , vol.22 , pp. 150-156
    • Lange, B.J.1    Dinndorf, P.2    Smith, F.O.3
  • 49
    • 4444369400 scopus 로고    scopus 로고
    • FLT3 internal tandem duplication is a prognostic factor for poor outcome in pediatric AML; a CCG-1961 study
    • Meshinchi S, Alonzo TA, Gerbing R, Lange B, Radich JP. FLT3 internal tandem duplication is a prognostic factor for poor outcome in pediatric AML; a CCG-1961 study [abstract]. Blood. 2003;102:335a.
    • (2003) Blood , vol.102
    • Meshinchi, S.1    Alonzo, T.A.2    Gerbing, R.3    Lange, B.4    Radich, J.P.5
  • 50
    • 0035476264 scopus 로고    scopus 로고
    • Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: A cancer and leukemia group B study
    • Whitman SP, Archer KJ, Feng L, et al. Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study. Cancer Res. 2001;61:7233-7239.
    • (2001) Cancer Res , vol.61 , pp. 7233-7239
    • Whitman, S.P.1    Archer, K.J.2    Feng, L.3
  • 51
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood. 2001;98:1752-1759.
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3
  • 52
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C, Steudel C, Mohr B, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood. 2002;99:4326-4335.
    • (2002) Blood , vol.99 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3
  • 53
    • 0023019005 scopus 로고
    • Use of MTT colorimetric assay to measure cell activation
    • Gerlier D, Thomasset N. Use of MTT colorimetric assay to measure cell activation. J Immunol Methods. 1986;94:57-63.
    • (1986) J Immunol Methods , vol.94 , pp. 57-63
    • Gerlier, D.1    Thomasset, N.2
  • 54
    • 0030054904 scopus 로고    scopus 로고
    • Flt3-ligand production by human bone marrow stromal cells
    • Lisovsky M, Braun SE, Ge Y, et al. Flt3-ligand production by human bone marrow stromal cells. Leukemia. 1996;10:1012-1018.
    • (1996) Leukemia , vol.10 , pp. 1012-1018
    • Lisovsky, M.1    Braun, S.E.2    Ge, Y.3
  • 55
    • 0034598830 scopus 로고    scopus 로고
    • Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    • Hayakawa F, Towatari M, Kiyoi H, et al. Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene. 2000;19:624-631.
    • (2000) Oncogene , vol.19 , pp. 624-631
    • Hayakawa, F.1    Towatari, M.2    Kiyoi, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.