Antisense oligodeoxyribonucleotide against the MLL-LTG19 chimeric transcript inhibits cell growth and induces apoptosis in cells of an infantile leukemia cell line carrying the t(11;19) chromosomal translocation

Cancer Research

Volumn 58, Issue 17, 1998, Pages 3773-3776

  Akao, Yukihiro ^a   Mizoguchi, Hiromi ^a   Misiura, Konrad ^c   Stec, Wojciech J ^c   Seto, Masao ^d   Ohishi, Nobuko ^b   Yagi, Kunio ^a,b  

^a GIFU INTERNATIONAL INSTITUTE OF BIOTECHNOLOGY   (Japan)

^b Institute of Applied Biochemistry   (Japan)

^c CENTRE OF MOLECULAR AND MACROMOLECULAR STUDIES   (Poland)

^d AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE;

ACUTE LEUKEMIA; APOPTOSIS; ARTICLE; B CELL LEUKEMIA; CELL GROWTH; CHILDHOOD LEUKEMIA; CHROMOSOME 11Q; CHROMOSOME TRANSLOCATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL;

APOPTOSIS; CELL DIVISION; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 19; DNA-BINDING PROTEINS; HUMANS; LEUKEMIA, B-CELL; MYELOID-LYMPHOID LEUKEMIA PROTEIN; OLIGONUCLEOTIDES, ANTISENSE; PROTO-ONCOGENES; RECOMBINANT FUSION PROTEINS; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0032170873     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Kaneko, Y., Shikano, T., Maseki, N., Sakurai, M., Takeda, T., Hiyoshi, Y., Miyama, J., and Fujimoto, T. Clinical characteristics of infant acute leukemias with or without 11q23 translocations. Leukemia (Baltimore), 2: 672-676, 1988.
2. Bernard, O. A., and Berger, B. Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations. Genes Chromosomes Cancer, 13: 75-85, 1995.
3. Gu, Y., Nakamura, T., Alder, H., Prasad, R., Canaani, O., Cimino, G., Croce, C. M., and Canaani, E. The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell, 71: 701-708, 1992.
4. Tkachuk, D. C., Kohler, S., and Cleary, M. L. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell, 71: 691-700, 1992.
5. Akao, Y., Seto, M., Yamamoto, K., Iida, S., Nakazawa, S., Inazawa, J., Abe, T., Takahashi, T., and Ueda, R. The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with 1(4;11) and t(11;19) translocations. Cancer Res., 52: 6083-6087, 1992.
6. Yamamoto, K., Seto, M., Komatsu, H., Iida, S., Akao, Y., Kojima, S., Kodera, Y., Nakazawa, S., Ariyoshi Y., Takahashi, T., and Ueda, R. Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia. Oncogene, 8: 2617-2625, 1993.
7. Prasad, R., Leshkowitz, D., Gu, Y., Alder, H., Nakamura, T., Saito, H., Huebner, K., Berger, R., Croce, C. M., and Canaani, E. Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia. Proc. Natl. Acad. Sci. USA, 91: 8107-8111, 1994.
8. Naoe, T., Kubo, K., Kiyoi, H., Ohno, R., Akao, Y., Yoshida, J., Kato, K., Kojima, S., and Matsuyama, T. Involvement of the MLL/ALL-1 gene associated with multiple point mutations of the N-ras gene in acute myeloid leukemia with t(11;17)(q23;q25). Blood, 196: 2260-2261, 1995.
9. Marukawa, O., Akao, Y., Inazawa, J., Ariyama, T., Abe, T., Naoe, T., Tanimoto, M., Saito, H., Otsuki, Y., and Tsujimoto, Y. Molecular cloning of the breakpoint of t(11;22)(q23;q11) chromosome translocation in an adult acute myelomonocytic leukemia. Br. J. Haematol., 62: 687-691, 1996.
10. Rabbitts, T. H. Chromosomal translocations in human cancer. Nature (Lond.), 372: 143-149, 1994.
11. Ramasamy, R., Kanagaratnam, R., Misiura, K., Rebowski, G., Amerakoon, R., and Stec, W. J. Anti-sense oligodeoxynucleotide phosphorothioates nonspecifically inhibit invasion of red blood cells by malaria parasites. Biochem. Biophys. Res. Commun., 218: 930-933, 1996.
12. Yagi, K., Noda, H., Kurono, M., and Ohishi, N. Efficient gene transfer with less cytotoxicity by means of cationic multilamellar liposomes. Biochem. Biophys. Res. Commun., 196: 1042-1048, 1993.
13. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
14. Joh, T., Kagami, Y., Yamamoto, K., Segawa, T., Takizawa, J., Takahashi, T., Ueda, R., and Seto, M. Identification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation. Oncogene, 13: 1945-1953, 1996.
15. Vaerman, J. L., Moureau, P., Deldime, F., Lewalle, P., Lammineur, C., Morschhauser, F., and Martial, P. Antisense oligodeoxyribonucleotides suppress hematologic cell growth through stepwise release of deoxyribonucleotides. Blood, 90: 331-339, 1997.
16. Huang, M. E., Ye, Y. C., Chen, S. R., Chai, J. R., Lu, J. X., Zhoa, L., Gu, L. J., and Wang, Z. Y. Use of all-trans-retinoic acid in the treatment of acute promyelocytic leukemia. Blood, 72: 567-572, 1988.
17. McGahon, A., Bissonnentte, R., Schmitte, M., Cotter, K. M., Green, D. R., and Cotter, T. G. BCR-ABL maintains resistance of chronic myelogeneous leukemia cells to apoptic cell death. Blood, 83: 1179-1187, 1994.
18. Mitani, K., Ogawa, S., Tanaka, T., Kurokawa, M., Yazaki, Y., and Hirai, H. Growth inhibition of leukemic cells carrying the t(3;21) by the AML1/EVI-1-specific anti-sense oligonucleotide. Br. J. Haematol., 90: 711-714, 1995.
19. Webb, A., Cunningham, D., Cotter, F., Clarke, P. A., di Stefano, F., Ross, P., Corbo, M., and Dziewanowska, Z. BCL-2 antisense therapy in patients with non-Hodgkin's hymphoma. Lancet, 349: 1137-1141, 1997.
20. Jansen, B., Schlagbauer-Wadl, H., Brown, B. D., Bryan, R. N., van Elas, A., Muller, M., Wolff, K., Eichler, H-G., and Pehamberger, H. bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice. Nat. Med., 4: 232-234, 1998.