MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

Nature Genetics

Volumn 30, Issue 1, 2002, Pages 41-47

  Armstrong, Scott A ^a,b,c   Staunton, Jane E ^d   Silverman, Lewis B ^a,b,c   Pieters, Rob ^e   Den Boer, Monique L ^e   Minden, Mark D ^f   Sallan, Stephen E ^a,b,c   Lander, Eric S ^d   Golub, Todd R ^a,b,c,d   Korsmeyer, Stanley J ^a,c,g  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^f UNIVERSITY OF TORONTO   (Canada)

^g HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CANCER SURVIVAL; CELL FATE; CHROMOSOME TRANSLOCATION; GENE CLUSTER; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC HETEROGENEITY; HUMAN; HUMAN CELL; MARKER GENE; PRIORITY JOURNAL; PROGNOSIS; STEM CELL; UNINDEXED SEQUENCE;

ACUTE DISEASE; CELL LINEAGE; DNA-BINDING PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, LEUKEMIC; GENES, HOMEOBOX; HEMATOPOIETIC STEM CELLS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOPHENOTYPING; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; LEUKEMIA, MYELOID; MYELOID-LYMPHOID LEUKEMIA PROTEIN; NEOPLASM PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ONCOGENE PROTEINS, FUSION; PROTO-ONCOGENES; RNA, MESSENGER; RNA, NEOPLASM; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC; TUMOR STEM CELLS;

EID: 18544375333     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng765     Document Type: Article

References (47)

1. The critical role of chromosome translocations in human leukemias
2. The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene
3. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias
4. Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
5. Clinical characteristics and treatment outcome of childhood acute lymphoblastic leukemia with the t(4;11)(q21;q23): A collaborative study of 40 cases
6. Human homologue of the rat chondroitin sulfate proteoglycan, NG2, detected by monoclonal antibody 7.1, identifies childhood acute lymphoblastic leukemias with t(4;11)(q21;q23) or t(11;19)(q23;p13) and MLL gene rearrangements
7. Mil rearrangements in haematological malignancies: Lessons from clinical and biological studies
8. Altered Hox expression and segmental identity in Mil-mutant mice
9. Defects in yolk sac hematopoiesis in Mll-null embryos
10. Homeobox genes in leukemogenesis
11. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia
12. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9
13. Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
14. B cell development pathways
15. Fates of human B-cell precursors
16. Role of helix-loop-helix proteins in lymphocyte development
17. Impaired B cell development and proliferation in absence of phosphoinositide-3-kinase p85α
18. B cell development and immunoglobulin gene transcription in the absence of Oct-2 and OBF-1
19. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
20. AC133, a novel marker for human hematopoietic stem and progenitor cells
21. Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells
22. Expression of rhombotin 2 in normal and leukaemic haemopoietic cells
23. Cyclin A1 expression in leukemia and normal hematopoietic cells
24. Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor
25. Human eosinophil cationic protein. Molecular cloning of a cytotoxin and helminthotoxin with ribonuclease activity
26. Murine Nkg2d and Cd94 are clustered within the natural killer complex and are expressed independently in natural killer cells
27. Identification of clonogenic common lymphoid progenitors in mouse bone marrow
28. Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias
29. Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4:11) abnormality
30. Multilineage gene expression precedes commitment in the hemopoietic system
31. Bipotential B-macrophage progenitors are present in adult bone marrow
32. Bipotential precursors of B cells and macrophages in murine fetal liver
33. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
34. + B lymphocytes and macrophages
35. Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development
36. Immunophenotypic and genotypic features, clinical characteristics, and treatment outcome of adult pro-B acute lymphoblastic leukemia: Results of the German multicenter trials GMALL 03/87 and 04/89
37. Intensified therapy for infants with acute lymphoblastic leukemia: Results from the Dana-Farber Cancer Institute Consortium
38. Relation between age, immunophenotype and in vitro drug resistance in 395 children with acute lymphoblastic leukemia - Implications for treatment of infants
39. All-trans-retinoic acid in acute promyelocytic leukemia
40. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
41. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
42. In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor
43. Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation
44. Incidence of TEL/AML1 fusion in children with relapsed acute lymphoblastic leukemia
45. Sensitivity of FISH in detection of MLL translocations