-
1
-
-
0034614490
-
Signaling: 2000 and beyond
-
Hunter T. Signaling: 2000 and beyond. Cell 2000;100:113-27.
-
(2000)
Cell
, vol.100
, pp. 113-127
-
-
Hunter, T.1
-
2
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science 2002;298: 1912-34.
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
3
-
-
0034693799
-
The protein tyrosine kinase family of the human genome
-
Robinson DR, Wu YM, Lin SF. The protein tyrosine kinase family of the human genome. Oncogene 2000;19:5548-57.
-
(2000)
Oncogene
, vol.19
, pp. 5548-5557
-
-
Robinson, D.R.1
Wu, Y.M.2
Lin, S.F.3
-
4
-
-
0035902180
-
Oncogenic kinase signalling
-
Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature 2001; 411:355-65.
-
(2001)
Nature
, vol.411
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
5
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335-42.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
6
-
-
0141465061
-
The role of FLT3 in haematopoietic malignancies
-
Stirewalt DL, Radich JP. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer 2003;3:650-65.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 650-665
-
-
Stirewalt, D.L.1
Radich, J.P.2
-
7
-
-
0013312329
-
Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification
-
Armstrong SA, Kung AL, Mabon ME, et al. Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. Cancer Cell 2003;3:173-83.
-
(2003)
Cancer Cell
, vol.3
, pp. 173-183
-
-
Armstrong, S.A.1
Kung, A.L.2
Mabon, M.E.3
-
8
-
-
0030451722
-
Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
-
Nakao M, Yokota S, Iwai T, et al. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia 1996;10:1911-8.
-
(1996)
Leukemia
, vol.10
, pp. 1911-1918
-
-
Nakao, M.1
Yokota, S.2
Iwai, T.3
-
9
-
-
0036595322
-
Finding the next Gleevec: FLT3 targeted kinase inhibitor therapy for acute myeloid leukemia
-
Sawyers CL. Finding the next Gleevec: FLT3 targeted kinase inhibitor therapy for acute myeloid leukemia. Cancer Cell 2002;1:413-5.
-
(2002)
Cancer Cell
, vol.1
, pp. 413-415
-
-
Sawyers, C.L.1
-
10
-
-
0141836914
-
FLT3: ITDoes matter in leukemia
-
Levis M, Small D. FLT3: ITDoes matter in leukemia. Leukemia 2003; 17:1738-52.
-
(2003)
Leukemia
, vol.17
, pp. 1738-1752
-
-
Levis, M.1
Small, D.2
-
12
-
-
0033883060
-
KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors
-
Lux ML, Rubin BP, Biase TL, et al. KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors. Am J Pathol 2002;156: 791-5.
-
(2002)
Am J Pathol
, vol.156
, pp. 791-795
-
-
Lux, M.L.1
Rubin, B.P.2
Biase, T.L.3
-
13
-
-
0038312141
-
Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase
-
U S A
-
Sommer G, Agosti V, Ehlers I, et al. Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase. Proc Natl Acad Sci U S A 2003;100:6706-11.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 6706-6711
-
-
Sommer, G.1
Agosti, V.2
Ehlers, I.3
-
14
-
-
0043169405
-
Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-Kit
-
Akin C, Brockow K, D'Ambrosio C, et al. Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-Kit. Exp Hematol 2003;31:686-92.
-
(2003)
Exp Hematol
, vol.31
, pp. 686-692
-
-
Akin, C.1
Brockow, K.2
D'Ambrosio, C.3
-
15
-
-
0030823968
-
Vascular endothelial growth factor is essential for initial but not continued in vivo growth of human breast carcinoma cells
-
Yoshiji H, Harris SR, Thorgeirsson UP. Vascular endothelial growth factor is essential for initial but not continued in vivo growth of human breast carcinoma cells. Cancer Res 1997;57:3924-8.
-
(1997)
Cancer Res
, vol.57
, pp. 3924-3928
-
-
Yoshiji, H.1
Harris, S.R.2
Thorgeirsson, U.P.3
-
16
-
-
0031038068
-
Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
-
Relf M, LeJeune S, Scott PA, et al. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res 1997;57:963-9.
-
(1997)
Cancer Res
, vol.57
, pp. 963-969
-
-
Relf, M.1
LeJeune, S.2
Scott, P.A.3
-
17
-
-
0036554864
-
Tumor-specific regulation of angiogenic growth factors and their receptors during recovery from cytotoxic therapy
-
Taylor AP, Osorio L, Craig R, et al. Tumor-specific regulation of angiogenic growth factors and their receptors during recovery from cytotoxic therapy. Clin Cancer Res 2002;8:1213-22.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1213-1222
-
-
Taylor, A.P.1
Osorio, L.2
Craig, R.3
-
18
-
-
0033617532
-
Effects of angiogenesis inhibitors on multistage carcinogenesis in mice
-
Bergers G, Javaherian K, Lo KM, Folkman J, Hanahan D. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science 1999;284:808-12.
-
(1999)
Science
, vol.284
, pp. 808-812
-
-
Bergers, G.1
Javaherian, K.2
Lo, K.M.3
Folkman, J.4
Hanahan, D.5
-
19
-
-
0035394833
-
Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: A role for altered tumor angiogenesis
-
Viloria-Petit A, Crombet T, Jothy S, et al. Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis. Cancer Res 2001;61:5090-101.
-
(2001)
Cancer Res
, vol.61
, pp. 5090-5101
-
-
Viloria-Petit, A.1
Crombet, T.2
Jothy, S.3
-
20
-
-
0038363443
-
Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2
-
Cao R, Brakenhielm E, Pawliuk R, et al. Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nat Med 2003;9:604-13.
-
(2003)
Nat Med
, vol.9
, pp. 604-613
-
-
Cao, R.1
Brakenhielm, E.2
Pawliuk, R.3
-
21
-
-
0037699955
-
Angiogenesis in health and disease
-
Carmeliet P. Angiogenesis in health and disease. Nat Med 2003;9:653-60.
-
(2003)
Nat Med
, vol.9
, pp. 653-660
-
-
Carmeliet, P.1
-
22
-
-
0032952010
-
Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
-
Benjamin LE, Golijanin D, Itin A, Pode D, Keshet E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 1999;103:159-65.
-
(1999)
J Clin Invest
, vol.103
, pp. 159-165
-
-
Benjamin, L.E.1
Golijanin, D.2
Itin, A.3
Pode, D.4
Keshet, E.5
-
24
-
-
0038476608
-
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
-
Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003;111:1287-95.
-
(2003)
J Clin Invest
, vol.111
, pp. 1287-1295
-
-
Bergers, G.1
Song, S.2
Meyer-Morse, N.3
Bergsland, E.4
Hanahan, D.5
-
25
-
-
0037280306
-
The role of VEGF in normal and neoplastic hematopoiesis
-
Gerber H-P, Ferrara N. The role of VEGF in normal and neoplastic hematopoiesis. J Mol Med 2003;81:20-31.
-
(2003)
J Mol Med
, vol.81
, pp. 20-31
-
-
Gerber, H.-P.1
Ferrara, N.2
-
26
-
-
0037989982
-
Tumors and their microenvironments: Tilling the soil: commentary re: A. M. Scott et al., A phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer
-
Cheng JD, Weiner LM. Tumors and their microenvironments: tilling the soil: commentary re: A. M. Scott et al., A phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. Clin Cancer Res 2003;9:1639-47.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1639-1647
-
-
Cheng, J.D.1
Weiner, L.M.2
-
27
-
-
0037990031
-
-
Clin Cancer Res 2003;9:1590-5.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1590-1595
-
-
-
28
-
-
0036113238
-
Tumor-associated fibroblasts (part I): Active stromal participants in tumor development and progression?
-
Kunz-Schughart LA, Knuechel R. Tumor-associated fibroblasts (part I): active stromal participants in tumor development and progression? Histol Histopathol 2002;17:599-621.
-
(2002)
Histol Histopathol
, vol.17
, pp. 599-621
-
-
Kunz-Schughart, L.A.1
Knuechel, R.2
-
30
-
-
0025103317
-
Fibroblast-mediated acceleration of human epithelial tumor growth in vivo
-
U S A
-
Camps JL, Chang SM, Hsu TC, et al. Fibroblast-mediated acceleration of human epithelial tumor growth in vivo. Proc Natl Acad Sci U S A 1990; 87:75-9.
-
(1990)
Proc Natl Acad Sci
, vol.87
, pp. 75-79
-
-
Camps, J.L.1
Chang, S.M.2
Hsu, T.C.3
-
31
-
-
0036344495
-
Revascularization of ischemic tissues by PIGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
-
Luttun A, Tjwa M, Moons L, et al. Revascularization of ischemic tissues by PIGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med 2002;8:831-40.
-
(2002)
Nat Med
, vol.8
, pp. 831-840
-
-
Luttun, A.1
Tjwa, M.2
Moons, L.3
-
32
-
-
0032889440
-
Granulocyte, granulocyte-macrophage, and macrophage colony-stimulating factors can stimulate the invasive capacity of human lung cancer cells
-
Pei XH, Nakanishi Y, Takayama K, Bai F, Hara N. Granulocyte, granulocyte-macrophage, and macrophage colony-stimulating factors can stimulate the invasive capacity of human lung cancer cells. Br J Cancer 1999;79:40-6.
-
(1999)
Br J Cancer
, vol.79
, pp. 40-46
-
-
Pei, X.H.1
Nakanishi, Y.2
Takayama, K.3
Bai, F.4
Hara, N.5
-
33
-
-
0031406090
-
The mast cell: Origin, morphology, distribution, and function
-
Yong LC, The mast cell: origin, morphology, distribution, and function. Exp Toxicol Pathol 1997;49:409-24.
-
(1997)
Exp Toxicol Pathol
, vol.49
, pp. 409-424
-
-
Yong, L.C.1
-
34
-
-
0033151608
-
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis
-
Coussens LM, Raymond WW, Bergers G, et al. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev 1999;13:1382-97.
-
(1999)
Genes Dev
, vol.13
, pp. 1382-1397
-
-
Coussens, L.M.1
Raymond, W.W.2
Bergers, G.3
-
35
-
-
12244298880
-
FLT3 inhibition as tailored therapy for acute myeloid leukemia
-
Martinelli G, Piccaluga PP, Lo Coco F. FLT3 inhibition as tailored therapy for acute myeloid leukemia. Haematologica 2003;88:4-8.
-
(2003)
Haematologica
, vol.88
, pp. 4-8
-
-
Martinelli, G.1
Piccaluga, P.P.2
Lo Coco, F.3
-
36
-
-
0038156174
-
Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor
-
Grundler R, Thiede C, Miething C, Steudel C, Peschel C, Duyster J. Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor. Blood 2003;102:646-51.
-
(2003)
Blood
, vol.102
, pp. 646-651
-
-
Grundler, R.1
Thiede, C.2
Miething, C.3
Steudel, C.4
Peschel, C.5
Duyster, J.6
-
37
-
-
0042357316
-
Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3)
-
Murata K, Kumagai H, Kawashima T, et al. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J Biol Chem 2003;278:32892-8.
-
(2003)
J Biol Chem
, vol.278
, pp. 32892-32898
-
-
Murata, K.1
Kumagai, H.2
Kawashima, T.3
-
38
-
-
0032402444
-
Clinical significance of plasma vascular endothelial growth factor in gastrointestinal cancer
-
Hyodo I, Doi T, Endo H, et al. Clinical significance of plasma vascular endothelial growth factor in gastrointestinal cancer. Eur J Cancer 1998;34:2041-5.
-
(1998)
Eur J Cancer
, vol.34
, pp. 2041-2045
-
-
Hyodo, I.1
Doi, T.2
Endo, H.3
-
39
-
-
0030821453
-
Vascular endothelial growth factor (VEGF) in human breast cancer: Correlation with disease-free survival
-
Obermair A, Kucera E, Mayerhofer K, et al. Vascular endothelial growth factor (VEGF) in human breast cancer: correlation with disease-free survival. Int J Cancer 1997;74:455-8.
-
(1997)
Int J Cancer
, vol.74
, pp. 455-458
-
-
Obermair, A.1
Kucera, E.2
Mayerhofer, K.3
-
40
-
-
33646559612
-
-
Indazole and benzisoxazole kinase inhibitors. U.S. Patent US 2004/ 0235892, Abbott Laboratories; 2003
-
Dai Y, Davidsen SK, Ericsson AM, Hartandi K, Ji Z, Michaelides MR. Indazole and benzisoxazole kinase inhibitors. U.S. Patent US 2004/ 0235892, Abbott Laboratories; 2003.
-
-
-
Dai, Y.1
Davidsen, S.K.2
Ericsson, A.M.3
Hartandi, K.4
Ji, Z.5
Michaelides, M.R.6
-
41
-
-
33646557379
-
-
Dosage forms and methods of treatment using VEGFR inhibitors. U.S. Patent US 2004/ 0224988, Agouron Pharmaceuticals, Inc.; 2004
-
Freddo J, Hu-Lowe D, Pithavala YK, Steinfeldt H. Dosage forms and methods of treatment using VEGFR inhibitors. U.S. Patent US 2004/ 0224988, Agouron Pharmaceuticals, Inc.; 2004.
-
-
-
Freddo, J.1
Hu-Lowe, D.2
Pithavala, Y.K.3
Steinfeldt, H.4
-
42
-
-
21044443128
-
In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models
-
Lee SH, Lopes de Menezes D, Vora J, et al. In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models. Clin Cancer Res 2005;11:3633-41.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3633-3641
-
-
Lee, S.H.1
Lopes De Menezes, D.2
Vora, J.3
-
43
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64:7099-109.
-
(2004)
Cancer Res
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
-
44
-
-
0037468875
-
Discovery of 5-[5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase
-
Sun L, Liang C, Shirazian S, et al. Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. J Med Chem 2003;46:1116-9.
-
(2003)
J Med Chem
, vol.46
, pp. 1116-1119
-
-
Sun, L.1
Liang, C.2
Shirazian, S.3
-
45
-
-
0034655182
-
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
-
Wood JM, Bold G, Buchdunger E, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res 2000;60:2178-89.
-
(2000)
Cancer Res
, vol.60
, pp. 2178-2189
-
-
Wood, J.M.1
Bold, G.2
Buchdunger, E.3
-
46
-
-
0031821433
-
Tyrosine kinase assays adapted to homogeneous time-resolved fluorescence
-
Kolb AJ, Kaplita PV, Hayes DJ, et al. Tyrosine kinase assays adapted to homogeneous time-resolved fluorescence. Drug Discovery Today 1998;3:333-42.
-
(1998)
Drug Discovery Today
, vol.3
, pp. 333-342
-
-
Kolb, A.J.1
Kaplita, P.V.2
Hayes, D.J.3
-
47
-
-
10744220705
-
Pseudosubstrate peptides inhibit Akt and induce cell growth inhibition
-
Luo Y, Smith RA, Guan R, et al. Pseudosubstrate peptides inhibit Akt and induce cell growth inhibition. Biochemistry 2004;43:1254-63.
-
(2004)
Biochemistry
, vol.43
, pp. 1254-1263
-
-
Luo, Y.1
Smith, R.A.2
Guan, R.3
-
48
-
-
33646559845
-
Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors
-
Guo J, Marcotte P, McCall JO, et al. Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors. Mol Cancer Ther 2006;5:1007-13.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 1007-1013
-
-
Guo, J.1
Marcotte, P.2
McCall, J.O.3
-
49
-
-
0034751861
-
Adult tissue angiogenesis: Evidence for negative regulation by estrogen in the uterus
-
Ma W, Tan J, Matsumoto H, et al. Adult tissue angiogenesis: evidence for negative regulation by estrogen in the uterus. Mol Endocrinol 2001;15:1983-92.
-
(2001)
Mol Endocrinol
, vol.15
, pp. 1983-1992
-
-
Ma, W.1
Tan, J.2
Matsumoto, H.3
-
50
-
-
9144262956
-
A novel orally bioavailable inhibitor of kinase insert domain-containing receptor induces antiangiogenic effects and prevents tumor growth in vivo
-
Sepp-Lorenzino L, Rands E, Mao X, et al. A novel orally bioavailable inhibitor of kinase insert domain-containing receptor induces antiangiogenic effects and prevents tumor growth in vivo. Cancer Res 2004;64:751-6.
-
(2004)
Cancer Res
, vol.64
, pp. 751-756
-
-
Sepp-Lorenzino, L.1
Rands, E.2
Mao, X.3
-
51
-
-
0024818355
-
Vascular endothelial growth factor is a secreted angiogenic mitogen
-
Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989;246:1306-9.
-
(1989)
Science
, vol.246
, pp. 1306-1309
-
-
Leung, D.W.1
Cachianes, G.2
Kuang, W.J.3
Goeddel, D.V.4
Ferrara, N.5
-
52
-
-
0037108298
-
SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase
-
Yee KWH, O'Farrell A-M, Smolich BD, et al. SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase. Blood 2002;100:2941-9.
-
(2002)
Blood
, vol.100
, pp. 2941-2949
-
-
Yee, K.W.H.1
O'Farrell, A.-M.2
Smolich, B.D.3
-
53
-
-
0345374198
-
Estradiol-induced vascular endothelial growth factor-A expression in breast tumor cells is biphasic and regulated by estrogen receptor-alpha dependent pathway
-
Sengupta K, Banerjee S, Saxena N, Banerjee SK. Estradiol-induced vascular endothelial growth factor-A expression in breast tumor cells is biphasic and regulated by estrogen receptor-alpha dependent pathway. Int J Oncol 2003;22:609-14.
-
(2003)
Int J Oncol
, vol.22
, pp. 609-614
-
-
Sengupta, K.1
Banerjee, S.2
Saxena, N.3
Banerjee, S.K.4
-
54
-
-
0036125150
-
CGP 79787D (PTK787/ZK222584), CGP 84738 NVP-AAC789, NVP-AAD777 and related 1-anilino-(4-pyridylme-thyl)phthalazines as inhibitors of VEGF- and bFGF-induced angiogenesis
-
Bold G, Frei J, Furet P, et al. CGP 79787D (PTK787/ZK222584), CGP 84738 NVP-AAC789, NVP-AAD777 and related 1-anilino-(4-pyridylme-thyl)phthalazines as inhibitors of VEGF- and bFGF-induced angiogenesis. Drugs Future 2002;27:43-55.
-
(2002)
Drugs Future
, vol.27
, pp. 43-55
-
-
Bold, G.1
Frei, J.2
Furet, P.3
-
55
-
-
0031901109
-
High cell density induces vascular endothelial growth factor expression via protein tyrosine phosphorylation
-
Mukhopadhyay D, Tsiokas L, Sukhatme VP. High cell density induces vascular endothelial growth factor expression via protein tyrosine phosphorylation. Gene Expr 1998;7:53-60.
-
(1998)
Gene Expr
, vol.7
, pp. 53-60
-
-
Mukhopadhyay, D.1
Tsiokas, L.2
Sukhatme, V.P.3
-
56
-
-
0026328893
-
Invasive human fibrosarcoma DNA mediated induction of a 92 kDa gelatinase/type-IV collagenase leads to an invasive phenotype
-
Kubota S, Mitsudomi T, Yamada Y. Invasive human fibrosarcoma DNA mediated induction of a 92 kDa gelatinase/type-IV collagenase leads to an invasive phenotype. Biochem Biophys Res Commun 1991;181:1539-47.
-
(1991)
Biochem Biophys Res Commun
, vol.181
, pp. 1539-1547
-
-
Kubota, S.1
Mitsudomi, T.2
Yamada, Y.3
-
57
-
-
78650874372
-
SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer
-
Abrams TJ, Lee LB, Murray LJ, Pryer NK, Cherrington JM. SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol Cancer Ther 2003;2:471-8.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 471-478
-
-
Abrams, T.J.1
Lee, L.B.2
Murray, L.J.3
Pryer, N.K.4
Cherrington, J.M.5
-
58
-
-
0035025022
-
Vascular endothelial growth factor gene expression in the human breast cancer cell line MX-1 is controlled by 02 availability in vitro and in vivo
-
Marxsen JH, Schmitt O, Metzen E, Jelkmann W, Hellwig-Burgel T. Vascular endothelial growth factor gene expression in the human breast cancer cell line MX-1 is controlled by 02 availability in vitro and in vivo. Ann Anat 2001;183:243-9.
-
(2001)
Ann Anat
, vol.183
, pp. 243-249
-
-
Marxsen, J.H.1
Schmitt, O.2
Metzen, E.3
Jelkmann, W.4
Hellwig-Burgel, T.5
-
60
-
-
14644415949
-
Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma
-
Rini BI, Small EJ. Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma. J Clin Oncol 2005;23:1028-43.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1028-1043
-
-
Rini, B.I.1
Small, E.J.2
-
61
-
-
3342940018
-
Inhibitors of angiogenesis and cancer-related receptor tyrosine kinases
-
Mazitschek R, Giannis A. Inhibitors of angiogenesis and cancer-related receptor tyrosine kinases. Curr Opin Chem Biol 2004;8:432-41.
-
(2004)
Curr Opin Chem Biol
, vol.8
, pp. 432-441
-
-
Mazitschek, R.1
Giannis, A.2
-
62
-
-
23844480013
-
Phase 2 trials of SU11248 show antitumor activity in second-line therapy for patients with metastatic renal cell carcinoma (RCC)
-
Motzer RJ, Rini BI, Michaelson MD, et al. Phase 2 trials of SU11248 show antitumor activity in second-line therapy for patients with metastatic renal cell carcinoma (RCC). 2005 ASCO Annual Meeting 2005;4508.
-
(2005)
2005 ASCO Annual Meeting
, pp. 4508
-
-
Motzer, R.J.1
Rini, B.I.2
Michaelson, M.D.3
-
63
-
-
33646540793
-
Highly selective kinase inhibitors: Too much of a good thing
-
abstract PL0401
-
Sebolt-Leopold JS, Merriman R, Klohs W, et al. Highly selective kinase inhibitors: too much of a good thing [abstract PL0401]? Clin Cancer Res Suppl 2003;9:6267-8S.
-
(2003)
Clin Cancer Res Suppl
, vol.9
-
-
Sebolt-Leopold, J.S.1
Merriman, R.2
Klohs, W.3
-
64
-
-
10744224610
-
Pharmacokinetic and pharmacodynamic evaluation of SU11248 in a phase I clinical trial of patients (pts) with imatinib-resistant gastrointestinal stromal tumor (GIST) [abstract 768]
-
Manning WC, Bello CL, Deprimo SE, et al. Pharmacokinetic and pharmacodynamic evaluation of SU11248 in a phase I clinical trial of patients (pts) with imatinib-resistant gastrointestinal stromal tumor (GIST) [abstract 768]. Proc Am Soc Clin Oncol 2003;22:192.
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 192
-
-
Manning, W.C.1
Bello, C.L.2
Deprimo, S.E.3
-
65
-
-
3042548695
-
Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
-
Inai T, Mancuso M, Hashizume H, et al. Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol 2004;165:35-52.
-
(2004)
Am J Pathol
, vol.165
, pp. 35-52
-
-
Inai, T.1
Mancuso, M.2
Hashizume, H.3
|