메뉴 건너뛰기




Volumn 5, Issue 4, 2006, Pages 995-1006

Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

ABT 869; ANTINEOPLASTIC AGENT; FLT3 LIGAND; N [4 (3 AMINO 1H INDAZOL 4 YL)PHENYL] N1 (2 FLUORO 5 METHYLPHENYL) UREA; PLATELET DERIVED GROWTH FACTOR; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; SUNITINIB; UNCLASSIFIED DRUG; VASCULOTROPIN; VATALANIB;

EID: 33646586669     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-05-0410     Document Type: Article
Times cited : (202)

References (65)
  • 1
    • 0034614490 scopus 로고    scopus 로고
    • Signaling: 2000 and beyond
    • Hunter T. Signaling: 2000 and beyond. Cell 2000;100:113-27.
    • (2000) Cell , vol.100 , pp. 113-127
    • Hunter, T.1
  • 3
    • 0034693799 scopus 로고    scopus 로고
    • The protein tyrosine kinase family of the human genome
    • Robinson DR, Wu YM, Lin SF. The protein tyrosine kinase family of the human genome. Oncogene 2000;19:5548-57.
    • (2000) Oncogene , vol.19 , pp. 5548-5557
    • Robinson, D.R.1    Wu, Y.M.2    Lin, S.F.3
  • 4
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature 2001; 411:355-65.
    • (2001) Nature , vol.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 5
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335-42.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 6
    • 0141465061 scopus 로고    scopus 로고
    • The role of FLT3 in haematopoietic malignancies
    • Stirewalt DL, Radich JP. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer 2003;3:650-65.
    • (2003) Nat Rev Cancer , vol.3 , pp. 650-665
    • Stirewalt, D.L.1    Radich, J.P.2
  • 7
    • 0013312329 scopus 로고    scopus 로고
    • Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification
    • Armstrong SA, Kung AL, Mabon ME, et al. Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. Cancer Cell 2003;3:173-83.
    • (2003) Cancer Cell , vol.3 , pp. 173-183
    • Armstrong, S.A.1    Kung, A.L.2    Mabon, M.E.3
  • 8
    • 0030451722 scopus 로고    scopus 로고
    • Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
    • Nakao M, Yokota S, Iwai T, et al. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia 1996;10:1911-8.
    • (1996) Leukemia , vol.10 , pp. 1911-1918
    • Nakao, M.1    Yokota, S.2    Iwai, T.3
  • 9
    • 0036595322 scopus 로고    scopus 로고
    • Finding the next Gleevec: FLT3 targeted kinase inhibitor therapy for acute myeloid leukemia
    • Sawyers CL. Finding the next Gleevec: FLT3 targeted kinase inhibitor therapy for acute myeloid leukemia. Cancer Cell 2002;1:413-5.
    • (2002) Cancer Cell , vol.1 , pp. 413-415
    • Sawyers, C.L.1
  • 10
    • 0141836914 scopus 로고    scopus 로고
    • FLT3: ITDoes matter in leukemia
    • Levis M, Small D. FLT3: ITDoes matter in leukemia. Leukemia 2003; 17:1738-52.
    • (2003) Leukemia , vol.17 , pp. 1738-1752
    • Levis, M.1    Small, D.2
  • 12
    • 0033883060 scopus 로고    scopus 로고
    • KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors
    • Lux ML, Rubin BP, Biase TL, et al. KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors. Am J Pathol 2002;156: 791-5.
    • (2002) Am J Pathol , vol.156 , pp. 791-795
    • Lux, M.L.1    Rubin, B.P.2    Biase, T.L.3
  • 13
    • 0038312141 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase
    • U S A
    • Sommer G, Agosti V, Ehlers I, et al. Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase. Proc Natl Acad Sci U S A 2003;100:6706-11.
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 6706-6711
    • Sommer, G.1    Agosti, V.2    Ehlers, I.3
  • 14
    • 0043169405 scopus 로고    scopus 로고
    • Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-Kit
    • Akin C, Brockow K, D'Ambrosio C, et al. Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-Kit. Exp Hematol 2003;31:686-92.
    • (2003) Exp Hematol , vol.31 , pp. 686-692
    • Akin, C.1    Brockow, K.2    D'Ambrosio, C.3
  • 15
    • 0030823968 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is essential for initial but not continued in vivo growth of human breast carcinoma cells
    • Yoshiji H, Harris SR, Thorgeirsson UP. Vascular endothelial growth factor is essential for initial but not continued in vivo growth of human breast carcinoma cells. Cancer Res 1997;57:3924-8.
    • (1997) Cancer Res , vol.57 , pp. 3924-3928
    • Yoshiji, H.1    Harris, S.R.2    Thorgeirsson, U.P.3
  • 16
    • 0031038068 scopus 로고    scopus 로고
    • Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
    • Relf M, LeJeune S, Scott PA, et al. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res 1997;57:963-9.
    • (1997) Cancer Res , vol.57 , pp. 963-969
    • Relf, M.1    LeJeune, S.2    Scott, P.A.3
  • 17
    • 0036554864 scopus 로고    scopus 로고
    • Tumor-specific regulation of angiogenic growth factors and their receptors during recovery from cytotoxic therapy
    • Taylor AP, Osorio L, Craig R, et al. Tumor-specific regulation of angiogenic growth factors and their receptors during recovery from cytotoxic therapy. Clin Cancer Res 2002;8:1213-22.
    • (2002) Clin Cancer Res , vol.8 , pp. 1213-1222
    • Taylor, A.P.1    Osorio, L.2    Craig, R.3
  • 18
    • 0033617532 scopus 로고    scopus 로고
    • Effects of angiogenesis inhibitors on multistage carcinogenesis in mice
    • Bergers G, Javaherian K, Lo KM, Folkman J, Hanahan D. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science 1999;284:808-12.
    • (1999) Science , vol.284 , pp. 808-812
    • Bergers, G.1    Javaherian, K.2    Lo, K.M.3    Folkman, J.4    Hanahan, D.5
  • 19
    • 0035394833 scopus 로고    scopus 로고
    • Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: A role for altered tumor angiogenesis
    • Viloria-Petit A, Crombet T, Jothy S, et al. Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis. Cancer Res 2001;61:5090-101.
    • (2001) Cancer Res , vol.61 , pp. 5090-5101
    • Viloria-Petit, A.1    Crombet, T.2    Jothy, S.3
  • 20
    • 0038363443 scopus 로고    scopus 로고
    • Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2
    • Cao R, Brakenhielm E, Pawliuk R, et al. Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nat Med 2003;9:604-13.
    • (2003) Nat Med , vol.9 , pp. 604-613
    • Cao, R.1    Brakenhielm, E.2    Pawliuk, R.3
  • 21
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. Angiogenesis in health and disease. Nat Med 2003;9:653-60.
    • (2003) Nat Med , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 22
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin LE, Golijanin D, Itin A, Pode D, Keshet E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 1999;103:159-65.
    • (1999) J Clin Invest , vol.103 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 24
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003;111:1287-95.
    • (2003) J Clin Invest , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 25
    • 0037280306 scopus 로고    scopus 로고
    • The role of VEGF in normal and neoplastic hematopoiesis
    • Gerber H-P, Ferrara N. The role of VEGF in normal and neoplastic hematopoiesis. J Mol Med 2003;81:20-31.
    • (2003) J Mol Med , vol.81 , pp. 20-31
    • Gerber, H.-P.1    Ferrara, N.2
  • 26
    • 0037989982 scopus 로고    scopus 로고
    • Tumors and their microenvironments: Tilling the soil: commentary re: A. M. Scott et al., A phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer
    • Cheng JD, Weiner LM. Tumors and their microenvironments: tilling the soil: commentary re: A. M. Scott et al., A phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. Clin Cancer Res 2003;9:1639-47.
    • (2003) Clin Cancer Res , vol.9 , pp. 1639-1647
    • Cheng, J.D.1    Weiner, L.M.2
  • 27
    • 0037990031 scopus 로고    scopus 로고
    • Clin Cancer Res 2003;9:1590-5.
    • (2003) Clin Cancer Res , vol.9 , pp. 1590-1595
  • 28
    • 0036113238 scopus 로고    scopus 로고
    • Tumor-associated fibroblasts (part I): Active stromal participants in tumor development and progression?
    • Kunz-Schughart LA, Knuechel R. Tumor-associated fibroblasts (part I): active stromal participants in tumor development and progression? Histol Histopathol 2002;17:599-621.
    • (2002) Histol Histopathol , vol.17 , pp. 599-621
    • Kunz-Schughart, L.A.1    Knuechel, R.2
  • 30
    • 0025103317 scopus 로고
    • Fibroblast-mediated acceleration of human epithelial tumor growth in vivo
    • U S A
    • Camps JL, Chang SM, Hsu TC, et al. Fibroblast-mediated acceleration of human epithelial tumor growth in vivo. Proc Natl Acad Sci U S A 1990; 87:75-9.
    • (1990) Proc Natl Acad Sci , vol.87 , pp. 75-79
    • Camps, J.L.1    Chang, S.M.2    Hsu, T.C.3
  • 31
    • 0036344495 scopus 로고    scopus 로고
    • Revascularization of ischemic tissues by PIGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    • Luttun A, Tjwa M, Moons L, et al. Revascularization of ischemic tissues by PIGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med 2002;8:831-40.
    • (2002) Nat Med , vol.8 , pp. 831-840
    • Luttun, A.1    Tjwa, M.2    Moons, L.3
  • 32
    • 0032889440 scopus 로고    scopus 로고
    • Granulocyte, granulocyte-macrophage, and macrophage colony-stimulating factors can stimulate the invasive capacity of human lung cancer cells
    • Pei XH, Nakanishi Y, Takayama K, Bai F, Hara N. Granulocyte, granulocyte-macrophage, and macrophage colony-stimulating factors can stimulate the invasive capacity of human lung cancer cells. Br J Cancer 1999;79:40-6.
    • (1999) Br J Cancer , vol.79 , pp. 40-46
    • Pei, X.H.1    Nakanishi, Y.2    Takayama, K.3    Bai, F.4    Hara, N.5
  • 33
    • 0031406090 scopus 로고    scopus 로고
    • The mast cell: Origin, morphology, distribution, and function
    • Yong LC, The mast cell: origin, morphology, distribution, and function. Exp Toxicol Pathol 1997;49:409-24.
    • (1997) Exp Toxicol Pathol , vol.49 , pp. 409-424
    • Yong, L.C.1
  • 34
    • 0033151608 scopus 로고    scopus 로고
    • Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis
    • Coussens LM, Raymond WW, Bergers G, et al. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev 1999;13:1382-97.
    • (1999) Genes Dev , vol.13 , pp. 1382-1397
    • Coussens, L.M.1    Raymond, W.W.2    Bergers, G.3
  • 35
    • 12244298880 scopus 로고    scopus 로고
    • FLT3 inhibition as tailored therapy for acute myeloid leukemia
    • Martinelli G, Piccaluga PP, Lo Coco F. FLT3 inhibition as tailored therapy for acute myeloid leukemia. Haematologica 2003;88:4-8.
    • (2003) Haematologica , vol.88 , pp. 4-8
    • Martinelli, G.1    Piccaluga, P.P.2    Lo Coco, F.3
  • 36
    • 0038156174 scopus 로고    scopus 로고
    • Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor
    • Grundler R, Thiede C, Miething C, Steudel C, Peschel C, Duyster J. Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor. Blood 2003;102:646-51.
    • (2003) Blood , vol.102 , pp. 646-651
    • Grundler, R.1    Thiede, C.2    Miething, C.3    Steudel, C.4    Peschel, C.5    Duyster, J.6
  • 37
    • 0042357316 scopus 로고    scopus 로고
    • Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3)
    • Murata K, Kumagai H, Kawashima T, et al. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J Biol Chem 2003;278:32892-8.
    • (2003) J Biol Chem , vol.278 , pp. 32892-32898
    • Murata, K.1    Kumagai, H.2    Kawashima, T.3
  • 38
    • 0032402444 scopus 로고    scopus 로고
    • Clinical significance of plasma vascular endothelial growth factor in gastrointestinal cancer
    • Hyodo I, Doi T, Endo H, et al. Clinical significance of plasma vascular endothelial growth factor in gastrointestinal cancer. Eur J Cancer 1998;34:2041-5.
    • (1998) Eur J Cancer , vol.34 , pp. 2041-2045
    • Hyodo, I.1    Doi, T.2    Endo, H.3
  • 39
    • 0030821453 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) in human breast cancer: Correlation with disease-free survival
    • Obermair A, Kucera E, Mayerhofer K, et al. Vascular endothelial growth factor (VEGF) in human breast cancer: correlation with disease-free survival. Int J Cancer 1997;74:455-8.
    • (1997) Int J Cancer , vol.74 , pp. 455-458
    • Obermair, A.1    Kucera, E.2    Mayerhofer, K.3
  • 40
    • 33646559612 scopus 로고    scopus 로고
    • Indazole and benzisoxazole kinase inhibitors. U.S. Patent US 2004/ 0235892, Abbott Laboratories; 2003
    • Dai Y, Davidsen SK, Ericsson AM, Hartandi K, Ji Z, Michaelides MR. Indazole and benzisoxazole kinase inhibitors. U.S. Patent US 2004/ 0235892, Abbott Laboratories; 2003.
    • Dai, Y.1    Davidsen, S.K.2    Ericsson, A.M.3    Hartandi, K.4    Ji, Z.5    Michaelides, M.R.6
  • 41
    • 33646557379 scopus 로고    scopus 로고
    • Dosage forms and methods of treatment using VEGFR inhibitors. U.S. Patent US 2004/ 0224988, Agouron Pharmaceuticals, Inc.; 2004
    • Freddo J, Hu-Lowe D, Pithavala YK, Steinfeldt H. Dosage forms and methods of treatment using VEGFR inhibitors. U.S. Patent US 2004/ 0224988, Agouron Pharmaceuticals, Inc.; 2004.
    • Freddo, J.1    Hu-Lowe, D.2    Pithavala, Y.K.3    Steinfeldt, H.4
  • 42
    • 21044443128 scopus 로고    scopus 로고
    • In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models
    • Lee SH, Lopes de Menezes D, Vora J, et al. In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models. Clin Cancer Res 2005;11:3633-41.
    • (2005) Clin Cancer Res , vol.11 , pp. 3633-3641
    • Lee, S.H.1    Lopes De Menezes, D.2    Vora, J.3
  • 43
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64:7099-109.
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 44
    • 0037468875 scopus 로고    scopus 로고
    • Discovery of 5-[5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase
    • Sun L, Liang C, Shirazian S, et al. Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. J Med Chem 2003;46:1116-9.
    • (2003) J Med Chem , vol.46 , pp. 1116-1119
    • Sun, L.1    Liang, C.2    Shirazian, S.3
  • 45
    • 0034655182 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
    • Wood JM, Bold G, Buchdunger E, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res 2000;60:2178-89.
    • (2000) Cancer Res , vol.60 , pp. 2178-2189
    • Wood, J.M.1    Bold, G.2    Buchdunger, E.3
  • 46
    • 0031821433 scopus 로고    scopus 로고
    • Tyrosine kinase assays adapted to homogeneous time-resolved fluorescence
    • Kolb AJ, Kaplita PV, Hayes DJ, et al. Tyrosine kinase assays adapted to homogeneous time-resolved fluorescence. Drug Discovery Today 1998;3:333-42.
    • (1998) Drug Discovery Today , vol.3 , pp. 333-342
    • Kolb, A.J.1    Kaplita, P.V.2    Hayes, D.J.3
  • 47
    • 10744220705 scopus 로고    scopus 로고
    • Pseudosubstrate peptides inhibit Akt and induce cell growth inhibition
    • Luo Y, Smith RA, Guan R, et al. Pseudosubstrate peptides inhibit Akt and induce cell growth inhibition. Biochemistry 2004;43:1254-63.
    • (2004) Biochemistry , vol.43 , pp. 1254-1263
    • Luo, Y.1    Smith, R.A.2    Guan, R.3
  • 48
    • 33646559845 scopus 로고    scopus 로고
    • Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors
    • Guo J, Marcotte P, McCall JO, et al. Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors. Mol Cancer Ther 2006;5:1007-13.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1007-1013
    • Guo, J.1    Marcotte, P.2    McCall, J.O.3
  • 49
    • 0034751861 scopus 로고    scopus 로고
    • Adult tissue angiogenesis: Evidence for negative regulation by estrogen in the uterus
    • Ma W, Tan J, Matsumoto H, et al. Adult tissue angiogenesis: evidence for negative regulation by estrogen in the uterus. Mol Endocrinol 2001;15:1983-92.
    • (2001) Mol Endocrinol , vol.15 , pp. 1983-1992
    • Ma, W.1    Tan, J.2    Matsumoto, H.3
  • 50
    • 9144262956 scopus 로고    scopus 로고
    • A novel orally bioavailable inhibitor of kinase insert domain-containing receptor induces antiangiogenic effects and prevents tumor growth in vivo
    • Sepp-Lorenzino L, Rands E, Mao X, et al. A novel orally bioavailable inhibitor of kinase insert domain-containing receptor induces antiangiogenic effects and prevents tumor growth in vivo. Cancer Res 2004;64:751-6.
    • (2004) Cancer Res , vol.64 , pp. 751-756
    • Sepp-Lorenzino, L.1    Rands, E.2    Mao, X.3
  • 51
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989;246:1306-9.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 52
    • 0037108298 scopus 로고    scopus 로고
    • SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase
    • Yee KWH, O'Farrell A-M, Smolich BD, et al. SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase. Blood 2002;100:2941-9.
    • (2002) Blood , vol.100 , pp. 2941-2949
    • Yee, K.W.H.1    O'Farrell, A.-M.2    Smolich, B.D.3
  • 53
    • 0345374198 scopus 로고    scopus 로고
    • Estradiol-induced vascular endothelial growth factor-A expression in breast tumor cells is biphasic and regulated by estrogen receptor-alpha dependent pathway
    • Sengupta K, Banerjee S, Saxena N, Banerjee SK. Estradiol-induced vascular endothelial growth factor-A expression in breast tumor cells is biphasic and regulated by estrogen receptor-alpha dependent pathway. Int J Oncol 2003;22:609-14.
    • (2003) Int J Oncol , vol.22 , pp. 609-614
    • Sengupta, K.1    Banerjee, S.2    Saxena, N.3    Banerjee, S.K.4
  • 54
    • 0036125150 scopus 로고    scopus 로고
    • CGP 79787D (PTK787/ZK222584), CGP 84738 NVP-AAC789, NVP-AAD777 and related 1-anilino-(4-pyridylme-thyl)phthalazines as inhibitors of VEGF- and bFGF-induced angiogenesis
    • Bold G, Frei J, Furet P, et al. CGP 79787D (PTK787/ZK222584), CGP 84738 NVP-AAC789, NVP-AAD777 and related 1-anilino-(4-pyridylme-thyl)phthalazines as inhibitors of VEGF- and bFGF-induced angiogenesis. Drugs Future 2002;27:43-55.
    • (2002) Drugs Future , vol.27 , pp. 43-55
    • Bold, G.1    Frei, J.2    Furet, P.3
  • 55
    • 0031901109 scopus 로고    scopus 로고
    • High cell density induces vascular endothelial growth factor expression via protein tyrosine phosphorylation
    • Mukhopadhyay D, Tsiokas L, Sukhatme VP. High cell density induces vascular endothelial growth factor expression via protein tyrosine phosphorylation. Gene Expr 1998;7:53-60.
    • (1998) Gene Expr , vol.7 , pp. 53-60
    • Mukhopadhyay, D.1    Tsiokas, L.2    Sukhatme, V.P.3
  • 56
    • 0026328893 scopus 로고
    • Invasive human fibrosarcoma DNA mediated induction of a 92 kDa gelatinase/type-IV collagenase leads to an invasive phenotype
    • Kubota S, Mitsudomi T, Yamada Y. Invasive human fibrosarcoma DNA mediated induction of a 92 kDa gelatinase/type-IV collagenase leads to an invasive phenotype. Biochem Biophys Res Commun 1991;181:1539-47.
    • (1991) Biochem Biophys Res Commun , vol.181 , pp. 1539-1547
    • Kubota, S.1    Mitsudomi, T.2    Yamada, Y.3
  • 57
    • 78650874372 scopus 로고    scopus 로고
    • SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer
    • Abrams TJ, Lee LB, Murray LJ, Pryer NK, Cherrington JM. SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol Cancer Ther 2003;2:471-8.
    • (2003) Mol Cancer Ther , vol.2 , pp. 471-478
    • Abrams, T.J.1    Lee, L.B.2    Murray, L.J.3    Pryer, N.K.4    Cherrington, J.M.5
  • 58
    • 0035025022 scopus 로고    scopus 로고
    • Vascular endothelial growth factor gene expression in the human breast cancer cell line MX-1 is controlled by 02 availability in vitro and in vivo
    • Marxsen JH, Schmitt O, Metzen E, Jelkmann W, Hellwig-Burgel T. Vascular endothelial growth factor gene expression in the human breast cancer cell line MX-1 is controlled by 02 availability in vitro and in vivo. Ann Anat 2001;183:243-9.
    • (2001) Ann Anat , vol.183 , pp. 243-249
    • Marxsen, J.H.1    Schmitt, O.2    Metzen, E.3    Jelkmann, W.4    Hellwig-Burgel, T.5
  • 60
    • 14644415949 scopus 로고    scopus 로고
    • Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma
    • Rini BI, Small EJ. Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma. J Clin Oncol 2005;23:1028-43.
    • (2005) J Clin Oncol , vol.23 , pp. 1028-1043
    • Rini, B.I.1    Small, E.J.2
  • 61
    • 3342940018 scopus 로고    scopus 로고
    • Inhibitors of angiogenesis and cancer-related receptor tyrosine kinases
    • Mazitschek R, Giannis A. Inhibitors of angiogenesis and cancer-related receptor tyrosine kinases. Curr Opin Chem Biol 2004;8:432-41.
    • (2004) Curr Opin Chem Biol , vol.8 , pp. 432-441
    • Mazitschek, R.1    Giannis, A.2
  • 62
    • 23844480013 scopus 로고    scopus 로고
    • Phase 2 trials of SU11248 show antitumor activity in second-line therapy for patients with metastatic renal cell carcinoma (RCC)
    • Motzer RJ, Rini BI, Michaelson MD, et al. Phase 2 trials of SU11248 show antitumor activity in second-line therapy for patients with metastatic renal cell carcinoma (RCC). 2005 ASCO Annual Meeting 2005;4508.
    • (2005) 2005 ASCO Annual Meeting , pp. 4508
    • Motzer, R.J.1    Rini, B.I.2    Michaelson, M.D.3
  • 63
    • 33646540793 scopus 로고    scopus 로고
    • Highly selective kinase inhibitors: Too much of a good thing
    • abstract PL0401
    • Sebolt-Leopold JS, Merriman R, Klohs W, et al. Highly selective kinase inhibitors: too much of a good thing [abstract PL0401]? Clin Cancer Res Suppl 2003;9:6267-8S.
    • (2003) Clin Cancer Res Suppl , vol.9
    • Sebolt-Leopold, J.S.1    Merriman, R.2    Klohs, W.3
  • 64
    • 10744224610 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic evaluation of SU11248 in a phase I clinical trial of patients (pts) with imatinib-resistant gastrointestinal stromal tumor (GIST) [abstract 768]
    • Manning WC, Bello CL, Deprimo SE, et al. Pharmacokinetic and pharmacodynamic evaluation of SU11248 in a phase I clinical trial of patients (pts) with imatinib-resistant gastrointestinal stromal tumor (GIST) [abstract 768]. Proc Am Soc Clin Oncol 2003;22:192.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 192
    • Manning, W.C.1    Bello, C.L.2    Deprimo, S.E.3
  • 65
    • 3042548695 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
    • Inai T, Mancuso M, Hashizume H, et al. Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol 2004;165:35-52.
    • (2004) Am J Pathol , vol.165 , pp. 35-52
    • Inai, T.1    Mancuso, M.2    Hashizume, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.