Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling

Journal of Experimental Medicine

Volumn 192, Issue 5, 2000, Pages 719-728

  Zhang, Shuli ^a,b   Fukuda, Seiji ^a,b   Lee, Younghee ^a,b   Hangoc, Giao ^a,b   Cooper, Scott ^a,b   Spolski, Rosanne ^c   Leonard, Warren J ^c   Broxmeyer, Hal E ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WALTHER CANCER INSTITUTE   (United States)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Flt3; Gene knockout; Hematopoiesis; Signal transducer and activator of transfection 5; Signal transduction

Indexed keywords

JANUS KINASE; PROTEIN TYROSINE KINASE; STAT5 PROTEIN; STAT5B PROTEIN;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CELL DIVISION; CELL LINE; COLONY-STIMULATING FACTORS; COS CELLS; DNA-BINDING PROTEINS; FMS-LIKE TYROSINE KINASE 3; HUMANS; JANUS KINASE 1; JANUS KINASE 2; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MILK PROTEINS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 0034605042     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.5.719     Document Type: Article

References (55)

1. Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells
2. Cloning of the human homologue of the murine flt3 ligand: A growth factor for early hematopoietic progenitor cells
3. Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs
4. Flt3 ligand stimulates/costimulates the growth of myeloid stem/progenitor cells
5. The flt3 ligand promotes the survival of primitive hemopoietic progenitor cells with myeloid as well as B lymphoid potential. Suppression of apoptosis and counteraction by TNF-alpha and TGF-beta
6. +++ human umbilical cord blood myeloid progenitors in serum-depleted culture medium
7. Hematopoietic receptors of class III receptor-type tyrosine kinases
8. The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: Synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors
9. + hematopoietic progenitor cells
10. c-kit ligand and Flt3 ligand: Stem, progenitor cell factors with overlapping yet distinct activities
11. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors
12. Characterization of the protein encoded by the flt3 (flk2) receptor-like tyrosine kinase gene
13. Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells
14. Biochemical characterization and analysis of the transforming potential of the FLT3/FLK2 receptor tyrosine kinase
15. Substrate specificities and identification of a putative binding site for PI3K in the carboxy tail of the murine Flt3 receptor tyrosine kinase
16. Analysis of the mitogenic pathway of the FLT3 receptor and characterization in its C terminal region of a specific binding site for the PI3' kinase
17. p85 subunit of Pi3 kinase does not bind to human Flt3 receptor, but associates with Shp2, Ship, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells
18. FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates
19. The CBL-related protein CBLB participates in FLT3 and interleukin-7 receptor signal transduction in pro-B cells
20. Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells
21. Cell-free activation of a DNA-binding protein by epidermal growth factor
22. Stat5a is mandatory for adult mammary gland development and lactogenesis
23. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
24. An indirect effect of Stat5a in IL-2-induced proliferation: A critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction
25. Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity
26. Measurement of interleukin-3 and other hematopoietic growth factors, such as GM-CSF, G-CSF, M-CSF, erythropoietin and the potent co-stimulating cytokines Steel factor and Flt-3 ligand
27. Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STATS homologs
28. Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue
29. Interleukin-3 signals through multiple isoforms of Stat5
30. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells
31. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
32. Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells
33. Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction
34. Critical proline residues of the cytoplasmic domain of the IL-5 receptor alpha chain and its function in IL-5-mediated activation of JAK kinase and STAT5
35. Interleukin-3-induced activation of the JAK/STAT pathway is prolonged by proteasome inhibitors
36. Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation
37. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor
38. Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells
39. Regulation of growth factor signaling as assessed by gene deletion and gene transduction
40. Enhanced myeloid progenitor cell cycling and apoptosis in mice lacking the chemokine receptor, CCR2
41. Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts
42. Formation of STAT5-containing DNA binding complexes in response to colony-stimulating factor-1 and platelet-derived growth factor
43. Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins
44. Stat6 and Jak1 are common elements in platelet-derived growth factor and interleukin-4 signal transduction pathways in NIH 3T3 fibroblasts
45. Stem cell factor, the JAK-STAT pathway and signal transduction
46. Stat1 associates with c-kit and is activated in response to stem cell factor
47. Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
48. Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons
49. Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. Selective activation of Jak2, Stat3, and Stat5b
50. Insulin selectively activates STAT5b, but not STAT5a, via a JAK2-independent signalling pathway in kym-1 rhabdomyosarcoma cells
51. Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption
52. Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor
53. Regulation of epidermal growth factor receptor by activated H-ras and V-myc oncogenes in mouse Balb/3T3 cells: Possible roles of AP-1
54. Association and direct activation of signal transducer and activator of transcription 1α by platelet-derived growth factor receptor
55. In vitro activation of Stat3 by epidermal growth factor receptor kinase