A high-throughput, fully automated liquid/liquid extraction liquid chromatography/mass spectrometry method for the quantitation of a new investigational drug ABT-869 and its metabolite A-849529 in human plasma samples

Rapid Communications in Mass Spectrometry

Volumn 20, Issue 20, 2006, Pages 3067-3075

  Rodila, Ramona C ^a   Kim, Joseph C ^a   Ji, Qin C ^b   El Shourbagy, Tawakol A ^a  

^a ABBOTT LABORATORIES   (United States)

^b 206 Carnegie Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOMOLECULES; ENDOTHELIAL CELLS; EXTRACTION; LIQUID CHROMATOGRAPHY; SPECTROMETRY;

COEFFICIENT OF VARIANCE; EXTRACTION LIQUID; FULLY AUTOMATED; HAMILTONS; HIGH-THROUGHPUT; INTER-ASSAY COEFFICIENTS; INTER-ASSAYS; LC-MS-MS; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; LIQUID-LIQUID EXTRACTION;

METABOLITES;

EID: 33750013392     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.2703     Document Type: Article

References (25)

1. Arora A, Scholar EM. J. Pharm. Exp. Ther. 2005; 315: 971. DOI: 10.1124/jpet.105.084145.
2. Carlson DM, Steinberg JL, Gordon G. Clin. Adv. Hematol. Oncol. 2005; 3: 703.
3. Jemal M. Biomed. Chromatogr. 2000; 14: 422.
4. Naidong W. J. Chromatogr. B 2003; 796: 209. DOI: 10.1016/j.jchromb.2003. 08.026.
5. Stokvis E, Rosing H, Beijnen JH. Mass Spectrom. Rev. 2005; 24: 887. DOI: 10.1002/mas.20046.
6. Hopfgartner G, Bourgogne E. Mass Spectrom. Rev. 2003; 22: 195. DOI: 10.1002/mas.10050.
7. Ji QC, Reimer TM, El-Shourbagy TA. J. Chromatogr. B 2004; 805: 67. DOI: 10.1016/j.jchromb.2004.02.014.
8. Xu N, Kim GE, Gregg H, Wagdy A, Swaine BA, Chang MS, El-Shourbagy TA. J. Pharm. Biomed. Anal. 2004; 36: 189. DOI: 10.1016/j.jpba.2004.05.013.
9. Riffel KA, Groff MA, Wenning L, Song H, Lo MW. J. Chromatogr. B 2005; 819: 293. DOI: 10.1016/j.chromb.2005.02.013.
10. Zweigenbaum J, Heinig K, Steinborner S, Wachs T, Henion J. Anal. Chem. 1999; 71: 2294. DOI: 10.1021/ac9813540.
11. Steinborner S, Henion J. Anal. Chem. 1999; 71: 2340. DOI: 10.1021/ac981294y.
12. Jemal M, Teitz D, Ouyang Z, Khan S. J. Chromatogr. B 1999; 732: 501.
13. Zhang N, Hoffman KL, Li W, Rossi DT. J. Pharm Biomed. 2000; 22: 131.
14. Zweigenbaum J, Henion J. Anal. Chem. 2000; 72: 2446. DOI: 10.1021/ac991413p.
15. Ramos L, Bakhtiar R, Tse FLS. Rapid Commun. Mass Spectrom. 2000; 14: 740.
16. Hoke SH II, Tomlinson JA II, Bolden RD, Morand KL, Pinkston JD, Wehmeyer KR. Anal. Chem. 2001; 73: 3083. DOI: 10.1021/ac0014820.
17. Shen Z, Wang S, Bakhtiar R. Rapid Commun. Mass Spectrom. 2002; 16: 332. DOI10.1002/rcm.580.
18. Bolden RD, Hoke SH II, Eichhold TH, McCauley-Myers DL, Wehmeyer KR. J. Chromatogr. B 2002; 772: 1.
19. Shen A, Skriba HT, Mai H, Weiboldt RC, Chang MS, Ji QC, El-Shourbagy TA. Proc. 48th ASMS Conf. Mass Spectrometry and Allied Topics, Long Beach, CA, 2000, Poster 296.
20. Zhou JY, Shen A, Ji QC, El-Shourbagy TA, Proc. 49th ASMS Con. Mass Spectrometry and Allied Topics, Chicago, IL, 2001, Poster 231.
21. Brignol N, McMahon LM, Luo S, Tse FLS. Rapid Commun. Mass Spectrom. 2001; 15: 898. DOI: 10.1002/rcm.323.
22. (a) Ji QC, Rodila RC, Kim JC, El-Shourbagy TA. Validation report for the determination of A-741439 in dog plasma with potassium EDTA as anticoagulant, Abbott Internal Report R&D/04/447.
23. (b) Ji QC, Rodila RC, Kim JC, El-Shourbagy TA. Validation report for the determination of A-741439 and A-849529 in rat plasma with potassium EDTA as anticoagulant, Abbott Internal Report R&D/04/448.
24. Ji QC, Rodila R, Gage EM, El-Shourbagy TA. Anal. Chem. 2003; 75: 7008. DOI: 10.1021/ac034930n.
25. Food and Drug Administration of the United States, Guidance for Industry-Bioanalytical Method Validation, US Department of Health and Human Services, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM), May, 2001. Available: http://www.fda.gov/cder/guidance/index. htm.