-
1
-
-
80053233055
-
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
-
Prinz, M., Priller, J., Sisodia, S. S. & Ransohoff, R. M. Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nature Neurosci. 14, 1227-1235 (2011).
-
(2011)
Nature Neurosci.
, vol.14
, pp. 1227-1235
-
-
Prinz, M.1
Priller, J.2
Sisodia, S.S.3
Ransohoff, R.M.4
-
2
-
-
84869156976
-
Development and homeostasis of "resident" myeloid cells: The case of the microglia
-
Gomez, P. E., Schulz, C. & Geissmann, F. Development and homeostasis of "resident" myeloid cells: the case of the microglia. Glia 61, 112-120 (2013).
-
(2013)
Glia
, vol.61
, pp. 112-120
-
-
Gomez, P.E.1
Schulz, C.2
Geissmann, F.3
-
3
-
-
76249095169
-
Development of monocytes, macrophages, and dendritic cells
-
Geissmann, F. et al. Development of monocytes, macrophages, and dendritic cells. Science 327, 656-661 (2010).
-
(2010)
Science
, vol.327
, pp. 656-661
-
-
Geissmann, F.1
-
4
-
-
84888063933
-
Beyond stem cells: Selfrenewal of differentiated macrophages
-
Sieweke, M. H. & Allen, J. E. Beyond stem cells: selfrenewal of differentiated macrophages. Science 342, 1242974 (2013).
-
(2013)
Science
, vol.342
, pp. 1242974
-
-
Sieweke, M.H.1
Allen, J.E.2
-
5
-
-
78650233802
-
Microglia in the CNS: Immigrants from another world
-
Prinz, M. & Mildner, A. Microglia in the CNS: immigrants from another world. Glia 59, 177-187 (2011).
-
(2011)
Glia
, vol.59
, pp. 177-187
-
-
Prinz, M.1
Mildner, A.2
-
6
-
-
84867740805
-
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
-
Gautier, E. L. et al. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nature Immunol. 13, 1118-1128 (2012).
-
(2012)
Nature Immunol.
, vol.13
, pp. 1118-1128
-
-
Gautier, E.L.1
-
7
-
-
80355136629
-
Studying the mononuclear phagocyte system in the molecular age
-
Chow, A., Brown, B. D. & Merad, M. Studying the mononuclear phagocyte system in the molecular age. Nature Rev. Immunol. 11, 788-798 (2011).
-
(2011)
Nature Rev. Immunol.
, vol.11
, pp. 788-798
-
-
Chow, A.1
Brown, B.D.2
Merad, M.3
-
8
-
-
84886654275
-
Tissue-resident macrophages
-
Davies, L. C., Jenkins, S. J., Allen, J. E. & Taylor, P. R. Tissue-resident macrophages. Nature Immunol. 14, 986-995 (2013).
-
(2013)
Nature Immunol.
, vol.14
, pp. 986-995
-
-
Davies, L.C.1
Jenkins, S.J.2
Allen, J.E.3
Taylor, P.R.4
-
9
-
-
84865987121
-
Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
-
Butovsky, O. et al. Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS. J. Clin. Invest. 122, 3063-3087 (2012).
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 3063-3087
-
-
Butovsky, O.1
-
10
-
-
78149360132
-
Fate mapping analysis reveals that adult microglia derive from primitive macrophages
-
Ginhoux, F. et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330, 841-845 (2010).
-
(2010)
Science
, vol.330
, pp. 841-845
-
-
Ginhoux, F.1
-
12
-
-
84859508307
-
A lineage of myeloid cells independent of Myb and hematopoietic stem cells
-
Schulz, C. et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science 336, 86-90 (2012).
-
(2012)
Science
, vol.336
, pp. 86-90
-
-
Schulz, C.1
-
13
-
-
84886953273
-
A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation
-
Goldmann, T. et al. A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation. Nature Neurosci. 16, 1618-1626 (2013).
-
(2013)
Nature Neurosci.
, vol.16
, pp. 1618-1626
-
-
Goldmann, T.1
-
14
-
-
84872765982
-
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis
-
Yona, S. et al. Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity 38, 79-91 (2013).
-
(2013)
Immunity
, vol.38
, pp. 79-91
-
-
Yona, S.1
-
15
-
-
84894574217
-
Microglia promote learningdependent synapse formation through brain-derived neurotrophic factor
-
Parkhurst, C. N. et al. Microglia promote learningdependent synapse formation through brain-derived neurotrophic factor. Cell 155, 1596-1609 (2013).
-
(2013)
Cell
, vol.155
, pp. 1596-1609
-
-
Parkhurst, C.N.1
-
16
-
-
43049177588
-
Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system
-
Prinz, M. et al. Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity 28, 675-686 (2008).
-
(2008)
Immunity
, vol.28
, pp. 675-686
-
-
Prinz, M.1
-
17
-
-
20044376483
-
Experimental autoimmune encephalomyelitis repressed by microglial paralysis
-
Heppner, F. L. et al. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nature Med. 11, 146-152 (2005).
-
(2005)
Nature Med.
, vol.11
, pp. 146-152
-
-
Heppner, F.L.1
-
18
-
-
84858076374
-
Genetic approaches to study glial cells in the rodent brain
-
Pfrieger, F. W. & Slezak, M. Genetic approaches to study glial cells in the rodent brain. Glia 60, 681-701 (2012).
-
(2012)
Glia
, vol.60
, pp. 681-701
-
-
Pfrieger, F.W.1
Slezak, M.2
-
19
-
-
84893725541
-
Antiviral drug ganciclovir is a potent inhibitor of microglial proliferation and neuroinflammation
-
Ding, Z. et al. Antiviral drug ganciclovir is a potent inhibitor of microglial proliferation and neuroinflammation. J. Exp. Med. 211, 189-198 (2014).
-
(2014)
J. Exp. Med.
, vol.211
, pp. 189-198
-
-
Ding, Z.1
-
20
-
-
84869172769
-
Microglia as modulators of cognition and neuropsychiatric disorders
-
Blank, T. & Prinz, M. Microglia as modulators of cognition and neuropsychiatric disorders. Glia 61, 62-70 (2013).
-
(2013)
Glia
, vol.61
, pp. 62-70
-
-
Blank, T.1
Prinz, M.2
-
21
-
-
84899465163
-
-
3rd edn (eds Kettenmann, H. & Ransom, B. R.) Oxford Univ. Press
-
Priller, J. in Neuroglia 3rd edn (eds Kettenmann, H. & Ransom, B. R.) 906-916 (Oxford Univ. Press, 2013).
-
(2013)
Neuroglia
, pp. 906-916
-
-
Priller, J.1
-
22
-
-
0023949553
-
Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
-
Hickey, W. F. & Kimura, H. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 239, 290-292 (1988).
-
(1988)
Science
, vol.239
, pp. 290-292
-
-
Hickey, W.F.1
Kimura, H.2
-
23
-
-
0026755999
-
Bone marrowderived elements in the central nervous system: An immunohistochemical and ultrastructural survey of rat chimeras
-
Hickey, W. F., Vass, K. & Lassmann, H. Bone marrowderived elements in the central nervous system: an immunohistochemical and ultrastructural survey of rat chimeras. J. Neuropathol. Exp. Neurol. 51, 246-256 (1992).
-
(1992)
J. Neuropathol. Exp. Neurol.
, vol.51
, pp. 246-256
-
-
Hickey, W.F.1
Vass, K.2
Lassmann, H.3
-
24
-
-
27644497255
-
Three pathways to mature macrophages in the early mouse yolk sac
-
Bertrand, J. Y. et al. Three pathways to mature macrophages in the early mouse yolk sac. Blood 106, 3004-3011 (2005).
-
(2005)
Blood
, vol.106
, pp. 3004-3011
-
-
Bertrand, J.Y.1
-
25
-
-
34247896991
-
Ontogeny of the hematopoietic system
-
Cumano, A. & Godin, I. Ontogeny of the hematopoietic system. Annu. Rev. Immunol. 25, 745-785 (2007).
-
(2007)
Annu. Rev. Immunol.
, vol.25
, pp. 745-785
-
-
Cumano, A.1
Godin, I.2
-
26
-
-
0026034802
-
Microglial progenitors with a high proliferative potential in the embryonic and adult mouse brain
-
Alliot, F., Lecain, E., Grima, B. & Pessac, B. Microglial progenitors with a high proliferative potential in the embryonic and adult mouse brain. Proc. Natl Acad. Sci. USA 88, 1541-1545 (1991).
-
(1991)
Proc. Natl Acad. Sci. USA
, vol.88
, pp. 1541-1545
-
-
Alliot, F.1
Lecain, E.2
Grima, B.3
Pessac, B.4
-
27
-
-
0032737272
-
Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain
-
Alliot, F., Godin, I. & Pessac, B. Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain. Brain Res. Dev. Brain Res. 117, 145-152 (1999).
-
(1999)
Brain Res. Dev. Brain Res.
, vol.117
, pp. 145-152
-
-
Alliot, F.1
Godin, I.2
Pessac, B.3
-
28
-
-
0025966282
-
The distribution of microglia and cell death in the fetal rat forebrain
-
Ashwell, K. The distribution of microglia and cell death in the fetal rat forebrain. Brain Res. Dev. Brain Res. 58, 1-12 (1991).
-
(1991)
Brain Res. Dev. Brain Res.
, vol.58
, pp. 1-12
-
-
Ashwell, K.1
-
29
-
-
0026552605
-
Turnover of resident microglia in the normal adult mouse brain
-
Lawson, L. J., Perry, V. H. & Gordon, S. Turnover of resident microglia in the normal adult mouse brain. Neuroscience 48, 405-415 (1992).
-
(1992)
Neuroscience
, vol.48
, pp. 405-415
-
-
Lawson, L.J.1
Perry, V.H.2
Gordon, S.3
-
30
-
-
0025335694
-
Localization of morphologically distinct microglial populations in the developing human fetal brain: Implications for ontogeny
-
Hutchins, K. D., Dickson, D. W., Rashbaum, W. K. & Lyman, W. D. Localization of morphologically distinct microglial populations in the developing human fetal brain: implications for ontogeny. Brain Res. Dev. Brain Res. 55, 95-102 (1990).
-
(1990)
Brain Res. Dev. Brain Res.
, vol.55
, pp. 95-102
-
-
Hutchins, K.D.1
Dickson, D.W.2
Rashbaum, W.K.3
Lyman, W.D.4
-
31
-
-
0033564675
-
Colonisation of the developing human brain and spinal cord by microglia: A review
-
Rezaie, P. & Male, D. Colonisation of the developing human brain and spinal cord by microglia: a review. Microsc. Res. Tech. 45, 359-382 (1999).
-
(1999)
Microsc. Res. Tech.
, vol.45
, pp. 359-382
-
-
Rezaie, P.1
Male, D.2
-
32
-
-
20544449468
-
Microglia in the cerebral wall of the human telencephalon at second trimester
-
Rezaie, P., Dean, A., Male, D. & Ulfig, N. Microglia in the cerebral wall of the human telencephalon at second trimester. Cereb. Cortex 15, 938-949 (2005).
-
(2005)
Cereb. Cortex
, vol.15
, pp. 938-949
-
-
Rezaie, P.1
Dean, A.2
Male, D.3
Ulfig, N.4
-
33
-
-
0026022020
-
Macrophages, microglial cells, and HLA-DR antigens in fetal and infant brain
-
Esiri, M. M., al Izzi, M. S. & Reading, M. C. Macrophages, microglial cells, and HLA-DR antigens in fetal and infant brain. J. Clin. Pathol. 44, 102-106 (1991).
-
(1991)
J. Clin. Pathol.
, vol.44
, pp. 102-106
-
-
Esiri, M.M.1
Al Izzi, M.S.2
Reading, M.C.3
-
34
-
-
77956461653
-
Early microglial colonization of the human forebrain and possible involvement in periventricular whitematter injury of preterm infants
-
Verney, C., Monier, A., Fallet-Bianco, C. & Gressens, P. Early microglial colonization of the human forebrain and possible involvement in periventricular whitematter injury of preterm infants. J. Anat. 217, 436-448 (2010).
-
(2010)
J. Anat.
, vol.217
, pp. 436-448
-
-
Verney, C.1
Monier, A.2
Fallet-Bianco, C.3
Gressens, P.4
-
35
-
-
84875940314
-
Factors regulating microglia activation
-
Kierdorf, K. & Prinz, M. Factors regulating microglia activation. Front. Cell Neurosci. 7, 44 (2013).
-
(2013)
Front. Cell Neurosci.
, vol.7
, pp. 44
-
-
Kierdorf, K.1
Prinz, M.2
-
36
-
-
0025179936
-
Microglia and cell death in the developing mouse cerebellum
-
Ashwell, K. Microglia and cell death in the developing mouse cerebellum. Brain Res. Dev. Brain Res. 55, 219-230 (1990).
-
(1990)
Brain Res. Dev. Brain Res.
, vol.55
, pp. 219-230
-
-
Ashwell, K.1
-
37
-
-
33846571886
-
The origin and cell lineage of microglia: New concepts
-
Chan, W. Y., Kohsaka, S. & Rezaie, P. The origin and cell lineage of microglia: new concepts. Brain Res. Rev. 53, 344-354 (2007).
-
(2007)
Brain Res. Rev.
, vol.53
, pp. 344-354
-
-
Chan, W.Y.1
Kohsaka, S.2
Rezaie, P.3
-
38
-
-
0034049748
-
Origins and functions of phagocytes in the embryo
-
Lichanska, A. M. & Hume, D. A. Origins and functions of phagocytes in the embryo. Exp. Hematol. 28, 601-611 (2000).
-
(2000)
Exp. Hematol.
, vol.28
, pp. 601-611
-
-
Lichanska, A.M.1
Hume, D.A.2
-
39
-
-
0036092801
-
Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects
-
Dai, X. M. et al. Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood 99, 111-120 (2002).
-
(2002)
Blood
, vol.99
, pp. 111-120
-
-
Dai, X.M.1
-
40
-
-
80055051144
-
Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits
-
Erblich, B., Zhu, L., Etgen, A. M., Dobrenis, K. & Pollard, J. W. Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits. PLoS ONE 6, e26317 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Erblich, B.1
Zhu, L.2
Etgen, A.M.3
Dobrenis, K.4
Pollard, J.W.5
-
41
-
-
0344734124
-
Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op/op mice
-
Wegiel, J. et al. Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op/op mice. Brain Res. 804, 135-139 (1998).
-
(1998)
Brain Res.
, vol.804
, pp. 135-139
-
-
Wegiel, J.1
-
42
-
-
0025332897
-
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
-
Yoshida, H. et al. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 345, 442-444 (1990).
-
(1990)
Nature
, vol.345
, pp. 442-444
-
-
Yoshida, H.1
-
43
-
-
7444254061
-
CSF-1 regulation of the wandering macrophage: Complexity in action
-
Pixley, F. J. & Stanley, E. R. CSF-1 regulation of the wandering macrophage: complexity in action. Trends Cell Biol. 14, 628-638 (2004).
-
(2004)
Trends Cell Biol.
, vol.14
, pp. 628-638
-
-
Pixley, F.J.1
Stanley, E.R.2
-
44
-
-
0022159492
-
The granulocyte-macrophage colony stimulating factors
-
Metcalf, D. The granulocyte-macrophage colony stimulating factors. Cell 43, 5-6 (1985).
-
(1985)
Cell
, vol.43
, pp. 5-6
-
-
Metcalf, D.1
-
45
-
-
0031587848
-
Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice
-
Lagasse, E. & Weissman, I. L. Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice. Cell 89, 1021-1031 (1997).
-
(1997)
Cell
, vol.89
, pp. 1021-1031
-
-
Lagasse, E.1
Weissman, I.L.2
-
46
-
-
0020446611
-
A stochastic model of self-renewal and commitment to differentiation of the primitive hemopoietic stem cells in culture
-
Nakahata, T., Gross, A. J. & Ogawa, M. A stochastic model of self-renewal and commitment to differentiation of the primitive hemopoietic stem cells in culture. J. Cell. Physiol. 113, 455-458 (1982).
-
(1982)
J. Cell. Physiol.
, vol.113
, pp. 455-458
-
-
Nakahata, T.1
Gross, A.J.2
Ogawa, M.3
-
47
-
-
44049092407
-
Discovery of a cytokine and its receptor by functional screening of the extracellular proteome
-
Lin, H. et al. Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science 320, 807-811 (2008).
-
(2008)
Science
, vol.320
, pp. 807-811
-
-
Lin, H.1
-
48
-
-
77957115690
-
Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptormediated regulation of myeloid cells
-
Wei, S. et al. Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptormediated regulation of myeloid cells. J. Leukoc. Biol. 88, 495-505 (2010).
-
(2010)
J. Leukoc. Biol.
, vol.88
, pp. 495-505
-
-
Wei, S.1
-
49
-
-
84870907320
-
Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia
-
Greter, M. et al. Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia. Immunity 37, 1050-1060 (2012).
-
(2012)
Immunity
, vol.37
, pp. 1050-1060
-
-
Greter, M.1
-
50
-
-
84864152036
-
IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
-
Wang, Y. et al. IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nature Immunol. 13, 753-760 (2012).
-
(2012)
Nature Immunol.
, vol.13
, pp. 753-760
-
-
Wang, Y.1
-
51
-
-
0035887068
-
Zebrafish early macrophages colonize cephalic mesenchyme and developing brain, retina, and epidermis through a M-CSF receptor-dependent invasive process
-
Herbomel, P., Thisse, B. & Thisse, C. Zebrafish early macrophages colonize cephalic mesenchyme and developing brain, retina, and epidermis through a M-CSF receptor-dependent invasive process. Dev. Biol. 238, 274-288 (2001).
-
(2001)
Dev. Biol.
, vol.238
, pp. 274-288
-
-
Herbomel, P.1
Thisse, B.2
Thisse, C.3
-
52
-
-
67649205726
-
Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and β-catenin
-
Otero, K. et al. Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and β-catenin. Nature Immunol. 10, 734-743 (2009).
-
(2009)
Nature Immunol.
, vol.10
, pp. 734-743
-
-
Otero, K.1
-
53
-
-
33846622099
-
Transcription factors in myeloid development: Balancing differentiation with transformation
-
Rosenbauer, F. & Tenen, D. G. Transcription factors in myeloid development: balancing differentiation with transformation. Nature Rev. Immunol. 7, 105-117 (2007).
-
(2007)
Nature Rev. Immunol.
, vol.7
, pp. 105-117
-
-
Rosenbauer, F.1
Tenen, D.G.2
-
56
-
-
84865022665
-
Regulation of postnatal forebrain amoeboid microglial cell proliferation and development by the transcription factor Runx1
-
Zusso, M. et al. Regulation of postnatal forebrain amoeboid microglial cell proliferation and development by the transcription factor Runx1. J. Neurosci. 32, 11285-11298 (2012).
-
(2012)
J. Neurosci.
, vol.32
, pp. 11285-11298
-
-
Zusso, M.1
-
57
-
-
84861878908
-
Runx1 regulates embryonic myeloid fate choice in zebrafish through a negative feedback loop inhibiting Pu
-
Jin, H. et al. Runx1 regulates embryonic myeloid fate choice in zebrafish through a negative feedback loop inhibiting Pu.1 expression. Blood 119, 5239-5249 (2012).
-
(2012)
1 Expression. Blood
, vol.119
, pp. 5239-5249
-
-
Jin, H.1
-
58
-
-
16044369709
-
Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene
-
Holtschke, T. et al. Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell 87, 307-317 (1996).
-
(1996)
Cell
, vol.87
, pp. 307-317
-
-
Holtschke, T.1
-
59
-
-
84861123981
-
IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype
-
Masuda, T. et al. IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype. Cell Rep. 1, 334-340 (2012).
-
(2012)
Cell Rep.
, vol.1
, pp. 334-340
-
-
Masuda, T.1
-
60
-
-
84866673725
-
Interferon regulatory factor 8/ interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia
-
Horiuchi, M. et al. Interferon regulatory factor 8/ interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia. J. Neuroinflammation 9, 227 (2012).
-
(2012)
J. Neuroinflammation
, vol.9
, pp. 227
-
-
Horiuchi, M.1
-
61
-
-
84875950146
-
IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS
-
Minten, C., Terry, R., Deffrasnes, C., King, N. J. & Campbell, I. L. IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS. PLoS ONE 7, e49851 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Minten, C.1
Terry, R.2
Deffrasnes, C.3
King, N.J.4
Campbell, I.L.5
-
62
-
-
80053156515
-
Dendritic cell and macrophage heterogeneity in vivo
-
Hashimoto, D., Miller, J. & Merad, M. Dendritic cell and macrophage heterogeneity in vivo. Immunity 35, 323-335 (2011).
-
(2011)
Immunity
, vol.35
, pp. 323-335
-
-
Hashimoto, D.1
Miller, J.2
Merad, M.3
-
63
-
-
19744380563
-
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
-
Nimmerjahn, A., Kirchhoff, F. & Helmchen, F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308, 1314-1318 (2005).
-
(2005)
Science
, vol.308
, pp. 1314-1318
-
-
Nimmerjahn, A.1
Kirchhoff, F.2
Helmchen, F.3
-
64
-
-
22244464662
-
ATP mediates rapid microglial response to local brain injury in vivo
-
Davalos, D. et al. ATP mediates rapid microglial response to local brain injury in vivo. Nature Neurosci. 8, 752-758 (2005).
-
(2005)
Nature Neurosci.
, vol.8
, pp. 752-758
-
-
Davalos, D.1
-
65
-
-
84862154879
-
Long-range Ca2+ waves transmit brain-damage signals to microglia
-
Sieger, D., Moritz, C., Ziegenhals, T., Prykhozhij, S. & Peri, F. Long-range Ca2+ waves transmit brain-damage signals to microglia. Dev. Cell 22, 1138-1148 (2012).
-
(2012)
Dev. Cell
, vol.22
, pp. 1138-1148
-
-
Sieger, D.1
Moritz, C.2
Ziegenhals, T.3
Prykhozhij, S.4
Peri, F.5
-
66
-
-
35548986304
-
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
-
Hanisch, U. K. & Kettenmann, H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nature Neurosci. 10, 1387-1394 (2007).
-
(2007)
Nature Neurosci.
, vol.10
, pp. 1387-1394
-
-
Hanisch, U.K.1
Kettenmann, H.2
-
67
-
-
77956976681
-
Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm
-
Biswas, S. K. & Mantovani, A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nature Immunol. 11, 889-896 (2010).
-
(2010)
Nature Immunol.
, vol.11
, pp. 889-896
-
-
Biswas, S.K.1
Mantovani, A.2
-
68
-
-
71749088821
-
CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization
-
Roca, H. et al. CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization. J. Biol. Chem. 284, 34342-34354 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 34342-34354
-
-
Roca, H.1
-
69
-
-
0035576207
-
Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: Granulomatous pathology is shaped by the pattern of L-arginine metabolism
-
Hesse, M. et al. Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism. J. Immunol. 167, 6533-6544 (2001).
-
(2001)
J. Immunol.
, vol.167
, pp. 6533-6544
-
-
Hesse, M.1
-
70
-
-
3543107212
-
Fibrotic disease and the TH1/TH2 paradigm
-
Wynn, T. A. Fibrotic disease and the TH1/TH2 paradigm. Nature Rev. Immunol. 4, 583-594 (2004).
-
(2004)
Nature Rev. Immunol.
, vol.4
, pp. 583-594
-
-
Wynn, T.A.1
-
71
-
-
79959379095
-
Repertoire of microglial and macrophage responses after spinal cord injury
-
David, S. & Kroner, A. Repertoire of microglial and macrophage responses after spinal cord injury. Nature Rev. Neurosci. 12, 388-399 (2011).
-
(2011)
Nature Rev. Neurosci.
, vol.12
, pp. 388-399
-
-
David, S.1
Kroner, A.2
-
72
-
-
2442698974
-
Type 2 monocyte and microglia differentiation mediated by glatiramer acetate therapy in patients with multiple sclerosis
-
Kim, H. J. et al. Type 2 monocyte and microglia differentiation mediated by glatiramer acetate therapy in patients with multiple sclerosis. J. Immunol. 172, 7144-7153 (2004).
-
(2004)
J. Immunol.
, vol.172
, pp. 7144-7153
-
-
Kim, H.J.1
-
73
-
-
84858072878
-
Comparison of polarization properties of human adult microglia and blood-derived macrophages
-
Durafourt, B. A. et al. Comparison of polarization properties of human adult microglia and blood-derived macrophages. Glia 60, 717-727 (2012).
-
(2012)
Glia
, vol.60
, pp. 717-727
-
-
Durafourt, B.A.1
-
74
-
-
70350558453
-
Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord
-
Kigerl, K. A. et al. Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J. Neurosci. 29, 13435-13444 (2009).
-
(2009)
J. Neurosci.
, vol.29
, pp. 13435-13444
-
-
Kigerl, K.A.1
-
75
-
-
84868209611
-
Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia
-
Hu, X. et al. Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia. Stroke 43, 3063-3070 (2012).
-
(2012)
Stroke
, vol.43
, pp. 3063-3070
-
-
Hu, X.1
-
76
-
-
84889084386
-
Microglia/macrophage polarization dynamics in white matter after traumatic brain injury
-
Wang, G. et al. Microglia/macrophage polarization dynamics in white matter after traumatic brain injury. J. Cereb. Blood Flow Metab. 33, 1864-1874 (2013).
-
(2013)
J. Cereb. Blood Flow Metab.
, vol.33
, pp. 1864-1874
-
-
Wang, G.1
-
77
-
-
84155164228
-
Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation
-
Choi, S. H., Aid, S., Kim, H. W., Jackson, S. H. & Bosetti, F. Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation. J. Neurochem. 120, 292-301 (2012).
-
(2012)
J. Neurochem.
, vol.120
, pp. 292-301
-
-
Choi, S.H.1
Aid, S.2
Kim, H.W.3
Jackson, S.H.4
Bosetti, F.5
-
78
-
-
50249144131
-
Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas
-
Komohara, Y., Ohnishi, K., Kuratsu, J. & Takeya, M. Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas. J. Pathol. 216, 15-24 (2008).
-
(2008)
J. Pathol.
, vol.216
, pp. 15-24
-
-
Komohara, Y.1
Ohnishi, K.2
Kuratsu, J.3
Takeya, M.4
-
79
-
-
84887481716
-
CSF-1R inhibition alters macrophage polarization and blocks glioma progression
-
Pyonteck, S. M. et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nature Med. 19, 1264-1272 (2013).
-
(2013)
Nature Med.
, vol.19
, pp. 1264-1272
-
-
Pyonteck, S.M.1
-
80
-
-
40449122005
-
Multiple sclerosis and Alzheimer's disease
-
Dal, B. A. et al. Multiple sclerosis and Alzheimer's disease. Ann. Neurol. 63, 174-183 (2008).
-
(2008)
Ann. Neurol.
, vol.63
, pp. 174-183
-
-
Dal, B.A.1
-
81
-
-
84874446407
-
Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status
-
Vogel, D. Y. et al. Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status. J. Neuroinflammation 10, 35 (2013).
-
(2013)
J. Neuroinflammation
, vol.10
, pp. 35
-
-
Vogel, D.Y.1
-
82
-
-
34247500821
-
TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis
-
Takahashi, K., Prinz, M., Stagi, M., Chechneva, O. & Neumann, H. TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis. PLoS Med. 4, e124 (2007).
-
(2007)
PLoS Med.
, vol.4
-
-
Takahashi, K.1
Prinz, M.2
Stagi, M.3
Chechneva, O.4
Neumann, H.5
-
83
-
-
84872057940
-
TREM2 variants in Alzheimer's disease
-
Guerreiro, R. et al. TREM2 variants in Alzheimer's disease. N. Engl. J. Med. 368, 117-127 (2013).
-
(2013)
N. Engl. J. Med.
, vol.368
, pp. 117-127
-
-
Guerreiro, R.1
-
84
-
-
84873087532
-
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
-
Heneka, M. T. et al. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 493, 674-678 (2012).
-
(2012)
Nature
, vol.493
, pp. 674-678
-
-
Heneka, M.T.1
-
85
-
-
84890804750
-
MiR-155 as a multiple sclerosisrelevant regulator of myeloid cell polarization
-
Moore, C. S. et al. miR-155 as a multiple sclerosisrelevant regulator of myeloid cell polarization. Ann. Neurol. 74, 709-720 (2013).
-
(2013)
Ann. Neurol.
, vol.74
, pp. 709-720
-
-
Moore, C.S.1
-
86
-
-
84863119109
-
Transforming growth factor betaactivated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function
-
Wang, Y. et al. Transforming growth factor betaactivated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function. Proc. Natl Acad. Sci. USA 109, E343-E352 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
-
-
Wang, Y.1
-
87
-
-
84883454794
-
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
-
Miron, V. E. et al. M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination. Nature Neurosci. 16, 1211-1218 (2013).
-
(2013)
Nature Neurosci.
, vol.16
, pp. 1211-1218
-
-
Miron, V.E.1
-
88
-
-
78650996588
-
Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis
-
Mikita, J. et al. Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration. Mult. Scler. 17, 2-15 (2011).
-
(2011)
Amelioration of Clinical Status by M2 Activated Monocyte Administration. Mult. Scler.
, vol.17
, pp. 2-15
-
-
Mikita, J.1
-
89
-
-
84880802569
-
A neurodegeneration-specific geneexpression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model
-
Chiu, I. M. et al. A neurodegeneration-specific geneexpression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. Cell Rep. 4, 385-401 (2013).
-
(2013)
Cell Rep.
, vol.4
, pp. 385-401
-
-
Chiu, I.M.1
-
90
-
-
36448994709
-
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
-
Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W. & Rossi, F. M. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nature Neurosci. 10, 1538-1543 (2007).
-
(2007)
Nature Neurosci.
, vol.10
, pp. 1538-1543
-
-
Ajami, B.1
Bennett, J.L.2
Krieger, C.3
Tetzlaff, W.4
Rossi, F.M.5
-
91
-
-
80052246111
-
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
-
Ajami, B., Bennett, J. L., Krieger, C., McNagny, K. M. & Rossi, F. M. Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool. Nature Neurosci. 14, 1142-1149 (2011).
-
(2011)
Nature Neurosci.
, vol.14
, pp. 1142-1149
-
-
Ajami, B.1
Bennett, J.L.2
Krieger, C.3
McNagny, K.M.4
Rossi, F.M.5
-
92
-
-
84874355139
-
Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice
-
Giovanoli, S. et al. Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice. Science 339, 1095-1099 (2013).
-
(2013)
Science
, vol.339
, pp. 1095-1099
-
-
Giovanoli, S.1
-
93
-
-
84877791206
-
Comment on "stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice"
-
Lazic, S. E. Comment on "Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice". Science 340, 811 (2013).
-
(2013)
Science
, vol.340
, pp. 811
-
-
Lazic, S.E.1
-
94
-
-
10644224469
-
Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse
-
Roumier, A. et al. Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse. J. Neurosci. 24, 11421-11428 (2004).
-
(2004)
J. Neurosci.
, vol.24
, pp. 11421-11428
-
-
Roumier, A.1
-
95
-
-
65249157852
-
Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals
-
Wake, H., Moorhouse, A. J., Jinno, S., Kohsaka, S. & Nabekura, J. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J. Neurosci. 29, 3974-3980 (2009).
-
(2009)
J. Neurosci.
, vol.29
, pp. 3974-3980
-
-
Wake, H.1
Moorhouse, A.J.2
Jinno, S.3
Kohsaka, S.4
Nabekura, J.5
-
96
-
-
80052633284
-
Synaptic pruning by microglia is necessary for normal brain development
-
Paolicelli, R. C. et al. Synaptic pruning by microglia is necessary for normal brain development. Science 333, 1456-1458 (2011).
-
(2011)
Science
, vol.333
, pp. 1456-1458
-
-
Paolicelli, R.C.1
-
97
-
-
78649976052
-
Microglial interactions with synapses are modulated by visual experience
-
Tremblay, M. E., Lowery, R. L. & Majewska, A. K. Microglial interactions with synapses are modulated by visual experience. PLoS Biol. 8, e1000527 (2010).
-
(2010)
PLoS Biol.
, vol.8
-
-
Tremblay, M.E.1
Lowery, R.L.2
Majewska, A.K.3
-
98
-
-
84861427387
-
Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
-
Schafer, D. P. et al. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 74, 691-705 (2012).
-
(2012)
Neuron
, vol.74
, pp. 691-705
-
-
Schafer, D.P.1
-
99
-
-
84887404953
-
Phagocytic glial cells: Sculpting synaptic circuits in the developing nervous system
-
Schafer, D. P. & Stevens, B. Phagocytic glial cells: sculpting synaptic circuits in the developing nervous system. Curr. Opin. Neurobiol. 23, 1034-1040 (2013).
-
(2013)
Curr. Opin. Neurobiol.
, vol.23
, pp. 1034-1040
-
-
Schafer, D.P.1
Stevens, B.2
-
100
-
-
84888324248
-
The microglial sensome revealed by direct RNA sequencing
-
Hickman, S. E. et al. The microglial sensome revealed by direct RNA sequencing. Nature Neurosci.16, 1896-1905 (2013).
-
(2013)
Nature Neurosci.
, vol.16
, pp. 1896-1905
-
-
Hickman, S.E.1
-
101
-
-
18544390923
-
Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype
-
Paloneva, J. et al. Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. Am. J. Hum. Genet. 71, 656-662 (2002).
-
(2002)
Am. J. Hum. Genet.
, vol.71
, pp. 656-662
-
-
Paloneva, J.1
-
102
-
-
84897954445
-
Microglial dysfunction in brain aging and Alzheimer's disease
-
Mosher, K. I. & Wyss-Coray, T. Microglial dysfunction in brain aging and Alzheimer's disease. Biochem. Pharmacol. http://dx.doi.org/10-1016/j. bcp.2014-01-008 (2014).
-
(2014)
Biochem. Pharmacol.
-
-
Mosher, K.I.1
Wyss-Coray, T.2
-
103
-
-
79955484414
-
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
-
Hollingworth, P. et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genet. 43, 429-435 (2011).
-
(2011)
Nature Genet.
, vol.43
, pp. 429-435
-
-
Hollingworth, P.1
-
104
-
-
79955464911
-
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with lateonset Alzheimer's disease
-
Naj, A. C. et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with lateonset Alzheimer's disease. Nature Genet. 43, 436-441 (2011).
-
(2011)
Nature Genet.
, vol.43
, pp. 436-441
-
-
Naj, A.C.1
-
105
-
-
84878433339
-
Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta
-
Griciuc, A. et al. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron 78, 631-643 (2013).
-
(2013)
Neuron
, vol.78
, pp. 631-643
-
-
Griciuc, A.1
-
106
-
-
84872586508
-
Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement
-
Guerreiro, R. J. et al. Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement. JAMA Neurol. 70, 78-84 (2013).
-
(2013)
JAMA Neurol.
, vol.70
, pp. 78-84
-
-
Guerreiro, R.J.1
-
107
-
-
84856273853
-
Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids
-
The first description of a primary 'microgliopathy' in humans
-
Rademakers, R. et al. Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids. Nature Genet. 44, 200-205 (2012). The first description of a primary 'microgliopathy' in humans.
-
(2012)
Nature Genet.
, vol.44
, pp. 200-205
-
-
Rademakers, R.1
-
108
-
-
67649876123
-
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
-
De Jager, P. L. et al. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nature Genet. 41, 776-782 (2009).
-
(2009)
Nature Genet.
, vol.41
, pp. 776-782
-
-
De Jager, P.L.1
-
109
-
-
79960334826
-
The genetic association of variants in CD6, TNFRSF1A and IRF8 to multiple sclerosis: A multicenter casecontrol study
-
International Multiple Sclerosis Genetics Consortium.
-
International Multiple Sclerosis Genetics Consortium. The genetic association of variants in CD6, TNFRSF1A and IRF8 to multiple sclerosis: a multicenter casecontrol study. PLoS ONE 6, e18813 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
-
110
-
-
0037963473
-
Blood monocytes consist of two principal subsets with distinct migratory properties
-
Geissmann, F., Jung, S. & Littman, D. R. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19, 71-82 (2003).
-
(2003)
Immunity
, vol.19
, pp. 71-82
-
-
Geissmann, F.1
Jung, S.2
Littman, D.R.3
-
111
-
-
84876207357
-
Nr4a1-dependent Ly6Clow monocytes monitor endothelial cells and orchestrate their disposal
-
Carlin, L. M. et al. Nr4a1-dependent Ly6Clow monocytes monitor endothelial cells and orchestrate their disposal. Cell 153, 362-375 (2013).
-
(2013)
Cell
, vol.153
, pp. 362-375
-
-
Carlin, L.M.1
-
112
-
-
84887611153
-
Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid β
-
Michaud, J. P., Bellavance, M. A., Prefontaine, P. & Rivest, S. Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid β. Cell Rep. 5, 646-653 (2013).
-
(2013)
Cell Rep.
, vol.5
, pp. 646-653
-
-
Michaud, J.P.1
Bellavance, M.A.2
Prefontaine, P.3
Rivest, S.4
-
113
-
-
79961234274
-
Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease
-
Mildner, A. et al. Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease. J. Neurosci. 31, 11159-11171 (2011).
-
(2011)
J. Neurosci.
, vol.31
, pp. 11159-11171
-
-
Mildner, A.1
-
114
-
-
59049104731
-
Selective targeting of perivascular macrophages for clearance of β-amyloid in cerebral amyloid angiopathy
-
Hawkes, C. A. & McLaurin, J. Selective targeting of perivascular macrophages for clearance of β-amyloid in cerebral amyloid angiopathy. Proc. Natl Acad. Sci. USA 106, 1261-1266 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 1261-1266
-
-
Hawkes, C.A.1
McLaurin, J.2
-
115
-
-
21444454120
-
Ineffective phagocytosis of amyloidbeta by macrophages of Alzheimer's disease patients
-
Fiala, M. et al. Ineffective phagocytosis of amyloidbeta by macrophages of Alzheimer's disease patients. J. Alzheimers. Dis. 7, 221-232 (2005).
-
(2005)
J. Alzheimers. Dis.
, vol.7
, pp. 221-232
-
-
Fiala, M.1
-
116
-
-
34547889114
-
Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin
-
Fiala, M. et al. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. Proc. Natl Acad. Sci. USA 104, 12849-12854 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 12849-12854
-
-
Fiala, M.1
-
117
-
-
0027327267
-
Association of apolipoprotein e allele e 4 with late-onset familial and sporadic Alzheimer's disease
-
Saunders, A. M. et al. Association of apolipoprotein E allele e 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43, 1467-1472 (1993).
-
(1993)
Neurology
, vol.43
, pp. 1467-1472
-
-
Saunders, A.M.1
-
118
-
-
44649197748
-
ApoE promotes the proteolytic degradation of Aβ
-
Jiang, Q. et al. ApoE promotes the proteolytic degradation of Aβ. Neuron 58, 681-693 (2008).
-
(2008)
Neuron
, vol.58
, pp. 681-693
-
-
Jiang, Q.1
-
119
-
-
84884185631
-
Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease
-
Lucin, K. M. et al. Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease. Neuron 79, 873-886 (2013).
-
(2013)
Neuron
, vol.79
, pp. 873-886
-
-
Lucin, K.M.1
-
120
-
-
84876006819
-
Functional impairment of microglia coincides with β-amyloid deposition in mice with Alzheimer-like pathology
-
Krabbe, G. et al. Functional impairment of microglia coincides with β-amyloid deposition in mice with Alzheimer-like pathology. PLoS ONE 8, e60921 (2013).
-
(2013)
PLoS ONE
, vol.8
-
-
Krabbe, G.1
-
121
-
-
0013615899
-
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
-
Yan, S. D. et al. RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease. Nature 382, 685-691 (1996).
-
(1996)
Nature
, vol.382
, pp. 685-691
-
-
Yan, S.D.1
-
122
-
-
0036584232
-
Peroxynitrite mediates neurotoxicity of amyloid β-peptide1-42- and lipopolysaccharideactivated microglia
-
Xie, Z. et al. Peroxynitrite mediates neurotoxicity of amyloid β-peptide1-42- and lipopolysaccharideactivated microglia. J. Neurosci. 22, 3484-3492 (2002).
-
(2002)
J. Neurosci.
, vol.22
, pp. 3484-3492
-
-
Xie, Z.1
-
123
-
-
74949127437
-
Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia
-
Grathwohl, S. A. et al. Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia. Nature Neurosci. 12, 1361-1363 (2009).
-
(2009)
Nature Neurosci.
, vol.12
, pp. 1361-1363
-
-
Grathwohl, S.A.1
-
124
-
-
84892748542
-
Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease
-
Doody, R. S. et al. Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease. N. Engl. J. Med. 370, 311-321 (2014).
-
(2014)
N. Engl. J. Med.
, vol.370
, pp. 311-321
-
-
Doody, R.S.1
-
125
-
-
84892695519
-
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease
-
Salloway, S. et al. Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. N. Engl. J. Med. 370, 322-333 (2014).
-
(2014)
N. Engl. J. Med.
, vol.370
, pp. 322-333
-
-
Salloway, S.1
-
126
-
-
47149112621
-
Long-term effects of Aβ42 immunisation in Alzheimer's disease: Follow-up of a randomised, placebo-controlled phase i trial
-
Holmes, C. et al. Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 372, 216-223 (2008).
-
(2008)
Lancet
, vol.372
, pp. 216-223
-
-
Holmes, C.1
-
127
-
-
68049143269
-
Infiltrating blood-derived macrophages are vital cells playing an antiinflammatory role in recovery from spinal cord injury in mice
-
Shechter, R. et al. Infiltrating blood-derived macrophages are vital cells playing an antiinflammatory role in recovery from spinal cord injury in mice. PLoS Med. 6, e1000113 (2009).
-
(2009)
PLoS Med.
, vol.6
-
-
Shechter, R.1
-
128
-
-
0032838089
-
Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury
-
Popovich, P. G. et al. Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury. Exp. Neurol. 158, 351-365 (1999).
-
(1999)
Exp. Neurol.
, vol.158
, pp. 351-365
-
-
Popovich, P.G.1
-
129
-
-
84875553508
-
Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus
-
Shechter, R. et al. Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus. Immunity 38, 555-569 (2013).
-
(2013)
Immunity
, vol.38
, pp. 555-569
-
-
Shechter, R.1
-
130
-
-
65149093082
-
Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease
-
King, I. L., Dickendesher, T. L. & Segal, B. M. Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease. Blood 113, 3190-3197 (2009).
-
(2009)
Blood
, vol.113
, pp. 3190-3197
-
-
King, I.L.1
Dickendesher, T.L.2
Segal, B.M.3
-
131
-
-
71549167047
-
CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system
-
Mildner, A. et al. CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system. Brain 132, 2487-2500 (2009).
-
(2009)
Brain
, vol.132
, pp. 2487-2500
-
-
Mildner, A.1
-
132
-
-
77956229704
-
Neuropathology after active Aβ42 immunotherapy: Implications for Alzheimer's disease pathogenesis
-
Boche, D., Denham, N., Holmes, C. & Nicoll, J. A. Neuropathology after active Aβ42 immunotherapy: implications for Alzheimer's disease pathogenesis. Acta Neuropathol. 120, 369-384 (2010).
-
(2010)
Acta Neuropathol.
, vol.120
, pp. 369-384
-
-
Boche, D.1
Denham, N.2
Holmes, C.3
Nicoll, J.A.4
-
133
-
-
0035658031
-
Targeting gene-modified hematopoietic cells to the central nervous system: Use of green fluorescent protein uncovers microglial engraftment
-
Priller, J. et al. Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment. Nature Med. 7, 1356-1361 (2001).
-
(2001)
Nature Med.
, vol.7
, pp. 1356-1361
-
-
Priller, J.1
-
134
-
-
33749258893
-
Circulating monocytes engraft in the brain, differentiate into microglia and contribute to the pathology following meningitis in mice
-
Djukic, M. et al. Circulating monocytes engraft in the brain, differentiate into microglia and contribute to the pathology following meningitis in mice. Brain 129, 2394-2403 (2006).
-
(2006)
Brain
, vol.129
, pp. 2394-2403
-
-
Djukic, M.1
-
135
-
-
33751098243
-
Early and rapid engraftment of bone marrow-derived microglia in scrapie
-
Priller, J. et al. Early and rapid engraftment of bone marrow-derived microglia in scrapie. J. Neurosci. 26, 11753-11762 (2006).
-
(2006)
J. Neurosci.
, vol.26
, pp. 11753-11762
-
-
Priller, J.1
-
136
-
-
6944234040
-
Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia
-
Simard, A. R. & Rivest, S. Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia. FASEB J. 18, 998-1000 (2004).
-
(2004)
FASEB J.
, vol.18
, pp. 998-1000
-
-
Simard, A.R.1
Rivest, S.2
-
137
-
-
0035958210
-
Differentiation of transplanted bone marrow cells in the adult mouse brain
-
Nakano, K., Migita, M., Mochizuki, H. & Shimada, T. Differentiation of transplanted bone marrow cells in the adult mouse brain. Transplantation 71, 1735-1740 (2001).
-
(2001)
Transplantation
, vol.71
, pp. 1735-1740
-
-
Nakano, K.1
Migita, M.2
Mochizuki, H.3
Shimada, T.4
-
138
-
-
0037114680
-
Neuroectodermal and microglial differentiation of bone marrow cells in the mouse spinal cord and sensory ganglia
-
Corti, S. et al. Neuroectodermal and microglial differentiation of bone marrow cells in the mouse spinal cord and sensory ganglia. J. Neurosci. Res. 70, 721-733 (2002).
-
(2002)
J. Neurosci. Res.
, vol.70
, pp. 721-733
-
-
Corti, S.1
-
139
-
-
0037775809
-
Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity
-
Vallieres, L. & Sawchenko, P. E. Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity. J. Neurosci. 23, 5197-5207 (2003).
-
(2003)
J. Neurosci.
, vol.23
, pp. 5197-5207
-
-
Vallieres, L.1
Sawchenko, P.E.2
-
140
-
-
0035476293
-
Transformation of donor-derived bone marrow precursors into host microglia during autoimmune CNS inflammation and during the retrograde response to axotomy
-
Flugel, A., Bradl, M., Kreutzberg, G. W. & Graeber, M. B. Transformation of donor-derived bone marrow precursors into host microglia during autoimmune CNS inflammation and during the retrograde response to axotomy. J. Neurosci. Res. 66, 74-82 (2001).
-
(2001)
J. Neurosci. Res.
, vol.66
, pp. 74-82
-
-
Flugel, A.1
Bradl, M.2
Kreutzberg, G.W.3
Graeber, M.B.4
-
141
-
-
2342524107
-
Bone marrow transdifferentiation in brain after transplantation: A retrospective study
-
Cogle, C. R. et al. Bone marrow transdifferentiation in brain after transplantation: a retrospective study. Lancet 363, 1432-1437 (2004).
-
(2004)
Lancet
, vol.363
, pp. 1432-1437
-
-
Cogle, C.R.1
-
142
-
-
0027275150
-
Male donor-derived cells in the brains of female sex-mismatched bone marrow transplant recipients: A Y-chromosome specific in situ hybridization study
-
Unger, E. R. et al. Male donor-derived cells in the brains of female sex-mismatched bone marrow transplant recipients: a Y-chromosome specific in situ hybridization study. J. Neuropathol. Exp. Neurol. 52, 460-470 (1993).
-
(1993)
J. Neuropathol. Exp. Neurol.
, vol.52
, pp. 460-470
-
-
Unger, E.R.1
-
143
-
-
0030787644
-
Kinetics of central nervous system microglial and macrophage engraftment: Analysis using a transgenic bone marrow transplantation model
-
Kennedy, D. W. & Abkowitz, J. L. Kinetics of central nervous system microglial and macrophage engraftment: analysis using a transgenic bone marrow transplantation model. Blood 90, 986-993 (1997).
-
(1997)
Blood
, vol.90
, pp. 986-993
-
-
Kennedy, D.W.1
Abkowitz, J.L.2
-
144
-
-
0027436887
-
Radiation bone marrow chimeras as a tool to study microglia turnover in normal brain and inflammation
-
Lassmann, H. & Hickey, W. F. Radiation bone marrow chimeras as a tool to study microglia turnover in normal brain and inflammation. Clin. Neuropathol. 12, 284-285 (1993).
-
(1993)
Clin. Neuropathol.
, vol.12
, pp. 284-285
-
-
Lassmann, H.1
Hickey, W.F.2
-
145
-
-
0028329894
-
Cells expressing human glucocerebrosidase from a retroviral vector repopulate macrophages and central nervous system microglia after murine bone marrow transplantation
-
Krall, W. J., Challita, P. M., Perlmutter, L. S., Skelton, D. C. & Kohn, D. B. Cells expressing human glucocerebrosidase from a retroviral vector repopulate macrophages and central nervous system microglia after murine bone marrow transplantation. Blood 83, 2737-2748 (1994).
-
(1994)
Blood
, vol.83
, pp. 2737-2748
-
-
Krall, W.J.1
Challita, P.M.2
Perlmutter, L.S.3
Skelton, D.C.4
Kohn, D.B.5
-
146
-
-
36448955070
-
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
-
Mildner, A. et al. Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions. Nature Neurosci. 10, 1544-1553 (2007).
-
(2007)
Nature Neurosci.
, vol.10
, pp. 1544-1553
-
-
Mildner, A.1
-
147
-
-
84866276426
-
Brain conditioning is instrumental for successful microglia reconstitution following hematopoietic stem cell transplantation
-
Capotondo, A. et al. Brain conditioning is instrumental for successful microglia reconstitution following hematopoietic stem cell transplantation. Proc. Natl Acad. Sci. USA 109, 15018-15023 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 15018-15023
-
-
Capotondo, A.1
-
148
-
-
84892389251
-
Targeting myeloid cells to the brain using non-myeloablative conditioning
-
Bottcher, C., Fernandez-Klett, F., Gladow, N., Rolfes, S. & Priller, J. Targeting myeloid cells to the brain using non-myeloablative conditioning. PLoS ONE 8, e80260 (2013).
-
(2013)
PLoS ONE
, vol.8
-
-
Bottcher, C.1
Fernandez-Klett, F.2
Gladow, N.3
Rolfes, S.4
Priller, J.5
-
149
-
-
84878584836
-
Busulfan conditioning enhances engraftment of hematopoietic donor-derived cells in the brain compared with irradiation
-
Wilkinson, F. L. et al. Busulfan conditioning enhances engraftment of hematopoietic donor-derived cells in the brain compared with irradiation. Mol. Ther. 21, 868-876 (2013).
-
(2013)
Mol. Ther.
, vol.21
, pp. 868-876
-
-
Wilkinson, F.L.1
-
150
-
-
84874782370
-
Bone marrow cell recruitment to the brain in the absence of irradiation or parabiosis bias
-
Kierdorf, K., Katzmarski, N., Haas, C. A. & Prinz, M. Bone marrow cell recruitment to the brain in the absence of irradiation or parabiosis bias. PLoS ONE 8, e58544 (2013).
-
(2013)
PLoS ONE
, vol.8
-
-
Kierdorf, K.1
Katzmarski, N.2
Haas, C.A.3
Prinz, M.4
-
151
-
-
70449427834
-
Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy
-
Cartier, N. et al. Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy. Science 326, 818-823 (2009).
-
(2009)
Science
, vol.326
, pp. 818-823
-
-
Cartier, N.1
-
152
-
-
84879873039
-
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy
-
Biffi, A. et al. Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy. Science 341, 1233158 (2013).
-
(2013)
Science
, vol.341
, pp. 1233158
-
-
Biffi, A.1
-
154
-
-
46749133930
-
Is microglial apoptosis an early pathogenic change in cerebral X-linked adrenoleukodystrophy?
-
Eichler, F. S. et al. Is microglial apoptosis an early pathogenic change in cerebral X-linked adrenoleukodystrophy? Ann. Neurol. 63, 729-742 (2008).
-
(2008)
Ann. Neurol.
, vol.63
, pp. 729-742
-
-
Eichler, F.S.1
-
155
-
-
33744798774
-
Onset and progression in inherited ALS determined by motor neurons and microglia
-
Boillee, S. et al. Onset and progression in inherited ALS determined by motor neurons and microglia. Science 312, 1389-1392 (2006).
-
(2006)
Science
, vol.312
, pp. 1389-1392
-
-
Boillee, S.1
-
156
-
-
32344440522
-
Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
-
Simard, A. R., Soulet, D., Gowing, G., Julien, J. P. & Rivest, S. Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 49, 489-502 (2006).
-
(2006)
Neuron
, vol.49
, pp. 489-502
-
-
Simard, A.R.1
Soulet, D.2
Gowing, G.3
Julien, J.P.4
Rivest, S.5
-
157
-
-
34147115541
-
Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease
-
El Khoury, J. et al. Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nature Med. 13, 432-438 (2007).
-
(2007)
Nature Med.
, vol.13
, pp. 432-438
-
-
El Khoury, J.1
-
158
-
-
77953282828
-
Hematopoietic origin of pathological grooming in Hoxb8 mutant mice
-
Chen, S. K. et al. Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Cell 141, 775-785 (2010).
-
(2010)
Cell
, vol.141
, pp. 775-785
-
-
Chen, S.K.1
-
159
-
-
84874936217
-
Mechanisms and therapeutic challenges in autism spectrum disorders: Insights from Rett syndrome
-
Castro, J., Mellios, N. & Sur, M. Mechanisms and therapeutic challenges in autism spectrum disorders: insights from Rett syndrome. Curr. Opin. Neurol. 26, 154-159 (2013).
-
(2013)
Curr. Opin. Neurol.
, vol.26
, pp. 154-159
-
-
Castro, J.1
Mellios, N.2
Sur, M.3
-
160
-
-
84859454582
-
Wild-type microglia arrest pathology in a mouse model of Rett syndrome
-
Together with reference 158, this report suggests that dysfunction of microglia may induce behavioural disturbances
-
Derecki, N. C. et al. Wild-type microglia arrest pathology in a mouse model of Rett syndrome. Nature 484, 105-109 (2012). Together with reference 158, this report suggests that dysfunction of microglia may induce behavioural disturbances.
-
(2012)
Nature
, vol.484
, pp. 105-109
-
-
Derecki, N.C.1
-
161
-
-
84864298329
-
Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages
-
Hoeffel, G. et al. Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages. J. Exp. Med. 209, 1167-1181 (2012).
-
(2012)
J. Exp. Med.
, vol.209
, pp. 1167-1181
-
-
Hoeffel, G.1
-
162
-
-
73949147392
-
Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network
-
Chorro, L. et al. Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network. J. Exp. Med. 206, 3089-3100 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 3089-3100
-
-
Chorro, L.1
-
163
-
-
84876775203
-
Tissue-resident macrophages selfmaintain locally throughout adult life with minimal contribution from circulating monocytes
-
Hashimoto, D. et al. Tissue-resident macrophages selfmaintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity 38, 792-804 (2013).
-
(2013)
Immunity
, vol.38
, pp. 792-804
-
-
Hashimoto, D.1
-
164
-
-
84885454468
-
Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF
-
Guilliams, M. et al. Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF. J. Exp. Med. 210, 1977-1992 (2013).
-
(2013)
J. Exp. Med.
, vol.210
, pp. 1977-1992
-
-
Guilliams, M.1
-
165
-
-
84887616366
-
Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin
-
Tamoutounour, S. et al. Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin. Immunity 39, 925-938 (2013).
-
(2013)
Immunity
, vol.39
, pp. 925-938
-
-
Tamoutounour, S.1
-
166
-
-
84880449489
-
GATA2 haploinsufficiency caused by mutations in a conserved intronic element leads to MonoMAC syndrome
-
Hsu, A. P. et al. GATA2 haploinsufficiency caused by mutations in a conserved intronic element leads to MonoMAC syndrome. Blood 121, 3830-3837 (2013).
-
(2013)
Blood
, vol.121
, pp. 3830-3837
-
-
Hsu, A.P.1
-
167
-
-
79960219807
-
IRF8 mutations and human dendritic-cell immunodeficiency
-
Hambleton, S. et al. IRF8 mutations and human dendritic-cell immunodeficiency. N. Engl. J. Med. 365, 127-138 (2011).
-
(2011)
N. Engl. J. Med.
, vol.365
, pp. 127-138
-
-
Hambleton, S.1
-
168
-
-
79961046334
-
Dendritic cell, monocyte, B and NK lymphoid deficiency defines the lost lineages of a new GATA-2 dependent myelodysplastic syndrome
-
Bigley, V. & Collin, M. Dendritic cell, monocyte, B and NK lymphoid deficiency defines the lost lineages of a new GATA-2 dependent myelodysplastic syndrome. Haematologica 96, 1081-1083 (2011).
-
(2011)
Haematologica
, vol.96
, pp. 1081-1083
-
-
Bigley, V.1
Collin, M.2
-
169
-
-
0028902162
-
Microglia in colonystimulating factor 1-deficient op/op mice
-
Blevins, G. & Fedoroff, S. Microglia in colonystimulating factor 1-deficient op/op mice. J. Neurosci. Res. 40, 535-544 (1995).
-
(1995)
J. Neurosci. Res.
, vol.40
, pp. 535-544
-
-
Blevins, G.1
Fedoroff, S.2
|