Circulating monocytes engraft in the brain, differentiate into microglia and contribute to the pathology following meningitis in mice

Brain

Volumn 129, Issue 9, 2006, Pages 2394-2403

  Djukic, Marija ^a   Mildner, Alexander ^a   Schmidt, Hauke ^a   Czesnik, Dirk ^a   Brück, Wolfgang ^a   Priller, Josef ^b   Nau, Roland ^a   Prinz, Marco ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

GFP chimeras; Meningitis; Microglia turnover; S. pneumoniae

Indexed keywords

BETA ACTIN; CEFTRIAXONE; GREEN FLUORESCENT PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; HLA ANTIGEN CLASS 2; LUMINESCENT AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BACTERIAL MENINGITIS; BONE MARROW CELL; BRAIN GRAFT; CELL DIFFERENTIATION; CELL LABELING; CELL STRUCTURE; CHIMERA; CONTROLLED STUDY; GENETIC ENGINEERING; LYSOSOME; MACROPHAGE; MICROGLIA; MONOCYTE; MOUSE; NONHUMAN; PARENCHYMA; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; STREPTOCOCCUS PNEUMONIAE; TARGET CELL; TISSUE INJURY; TRANSGENIC MOUSE; UPREGULATION; ANIMAL; BONE MARROW TRANSPLANTATION; BRAIN; C57BL MOUSE; CEREBELLUM; HEMATOPOIETIC STEM CELL; HIPPOCAMPUS; METHODOLOGY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TEMPORAL LOBE;

ANIMALS; BONE MARROW TRANSPLANTATION; BRAIN; CELL DIFFERENTIATION; CEREBELLUM; GREEN FLUORESCENT PROTEINS; HEMATOPOIETIC STEM CELLS; HIPPOCAMPUS; HISTOCOMPATIBILITY ANTIGENS CLASS II; LUMINESCENT AGENTS; MACROPHAGES; MENINGITIS, PNEUMOCOCCAL; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; MONOCYTES; TEMPORAL LOBE; UP-REGULATION;

EID: 33749258893     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awl206     Document Type: Article

References (34)

1. Angstwurm K, Hanisch UK, Gassemi T, Bille MB, Prinz M, Dirnagl U, et al. Tyrosine kinase inhibition reduces inflammation in the acute stage of experimental pneumococcal meningitis. Infect Immun 2004; 72: 3294-8.
2. Bechmann I, Goldmann J, Kovac AD, Kwidzinski E, Simburger E, Naftolin F, et al. Circulating monocytic cells infiltrate layers of anterograde axonal degeneration where they transform into microglia. FASEB J 2005; 19: 647-9.
3. Benveniste EN. Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J Mol Med 1997; 75: 165-73.
4. Biffi A, De Palma M, Quattrini A, Del Carro U, Amadio S, Visigalli I, et al. Correction of metachromatic leukodystrophy in the mouse model by transplantation of genetically modified hematopoietic stem cells. J Clin Invest 2004; 113: 1118-29.
5. Bohr V, Paulson OB, Rasmussen N. Pneumococcal meningitis. Late neurologic sequelae and features of prognostic impact. Arch Neurol 1984; 41: 1045-9.
6. Combs CK, Karlo JC, Kao SC, Landreth GE. Beta-amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J Neurosci 2001; 21: 1179-88.
7. Guillemin GJ, Brew BJ. Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification. J Leukoc Biol 2004; 75: 388-97.
8. Hanisch UK. Microglia as a source and target of cytokines. Glia 2002; 40: 140-55.
9. Hickey WF. Leukocyte traffic in the central nervous system: the participants and their roles. Semin Immunol 1999; 11: 125-37.
10. Hickey WF, Vass K, Lassmann H. Bone marrow-derived elements in the central nervous system: an immunohistochemical and ultrastructural survey of rat chimeras. J Neuropathol Exp Neurol 1992; 51: 246-56.
11. Iliev AI, Stringaris AK, Nau R, Neumann H. Neuronal injury mediated via stimulation of microglial toll-like receptor-9 (TLR9). FASEB J 2004; 18: 412-4.
12. Kielian T. Microglia and chemokines in infectious diseases of the nervous system: views and reviews. Front Biosci 2004; 9: 732-50.
13. Kreutzberg GW. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 1996; 19: 312-8.
14. Krivit W, Sung JH, Shapiro EG, Lockman LA. Microglia: the effector cell for reconstitution of the central nervous system following bone marrow transplantation for lysosomal and peroxisomal storage diseases. Cell Transplant 1995; 4: 385-92.
15. Krivit W, Aubourg P, Shapiro E, Peters C. Bone marrow transplantation for globoid cell leukodystrophy, adrenoleukodystrophy, metachromatic leukodystrophy, and hurler syndrome. Curr Opin Hematol 1999; 6: 377-82.
16. Mezey E, Chandross KJ, Harta G, Maki RA, McKercher SR. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 2000; 290: 1779-82.
17. Nau R, Bruck W. Neuronal injury in bacterial meningitis: mechanisms and implications for therapy. Trends Neurosci 2002; 25: 38-45.
18. Nau R, Gerber J, Bunkowski S, Bruck W. Axonal injury, a neglected cause of CNS damage in bacterial meningitis. Neurology 2004; 62: 509-11.
19. Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005; 308: 1314-8.
20. Okabe M, Ikawa M, Kominami K, Nakanishi T, Nishimune Y. 'Green mice' as a source of ubiquitous green cells. FEBS Lett 1997; 407: 313-9.
21. Ostergaard C, Yieng-Kow RV, Larsen CG, Mukaida N, Matsushima K, Benfield T, et al. Treatment with a monocolonal antibody to IL-8 attenuates the pleocytosis in experimental pneumococcal meningitis in rabbits when given intravenously, but not intracisternally. Clin Exp Immunol 2000; 122: 207-11.
22. Perry VH. The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative disease. Brain Behav Immun 2004; 18: 407-13.
23. Peters C, Steward CG. National Marrow Donor Program, International Bone Marrow Transplant Registry, Working Party on Inborn Errors, European Bone Marrow Transplant Group. Hematopoietic cell transplantation for inherited metabolic diseases: an overview of outcomes and practice guidelines. Bone Marrow Transplant 2003; 31: 229-39.
24. Priller J, Flügel A, Wehner T, Boentert M, Haas CA, Prinz M, et al. Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment. Nat Med 2001a; 7: 1356-61.
25. Priller J, Persons DA, Klett FF, Kempermann G, Kreutzberg GW, Dirnagl U. Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo. J Cell Biol 2001b; 155: 733-8.
26. Prinz M, Hanisch UK. Murine microglial cells produce and respond to interleukin-18. J Neurochem 1999; 72: 2215-8.
27. Prinz M, Heikenwalder M, Junt T, Schwarz P, Glatzel M, Heppner FL, et al. Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion. Nature 2003; 425: 957-62.
28. Prinz M, Garbe F, Schmidt H, Mildner A, Gutcher I, Wolter K, et al. Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis. J Clin Invest 2006; 116: 456-64.
29. Schmidt H, Heimann B, Djukic M, Mazurek C, Fels C, Wallesch CW, et al. Neuropsychological sequelae of bacterial and viral meningitis. Brain 2006; 129: 333-45.
30. Stalder AK, Ermini F, Bondolfi L, Krenger W, Burbach GJ, Deller T, et al. Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice. J Neurosci 2005; 25: 11125-32.
31. Streit WJ, Mrak RE, Griffin WS. Microglia and neuroinflammation: a pathological perspective. J Neuroinflammation 2004; 1: 14.
32. Tang T, Frenette PS, Hynes RO, Wagner DD, Mayadas TN. Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins. J Clin Invest 1996; 97: 2485-90.
33. Wehner T, Bontert M, Eyupoglu I, Prass K, Prinz M, Klett FF, et al. Bone marrow-derived cells expressing green fluorescent protein under the control of the glial fibrillary acidic protein promoter do not differentiate into astrocytes in vitro and in vivo. J Neurosci 2003; 23: 5004-11.
34. Zwijnenburg PJ, van der PT, Florquin S, van Deventer SJ, Roord JJ, van Furth AM. Experimental pneumococcal meningitis in mice: a model of intranasal infection. J Infect Dis 2001; 183: 1143-6.