메뉴 건너뛰기




Volumn 7, Issue 2, 2007, Pages 105-117

Transcription factors in myeloid development: Balancing differentiation with transformation

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; CCAAT ENHANCER BINDING PROTEIN EPSILON; FLT3 INHIBITOR; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; PROTEIN INHIBITOR; RETINOIC ACID; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR GFI1; TRANSCRIPTION FACTOR PU 1; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR SCL; UNCLASSIFIED DRUG;

EID: 33846622099     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri2024     Document Type: Review
Times cited : (482)

References (142)
  • 1
    • 0030854907 scopus 로고    scopus 로고
    • Transcription factors, normal myeloid development, and leukemia
    • Tenen, D. G., Hromas, R., Licht, J. D. & Zhang, D. E. Transcription factors, normal myeloid development, and leukemia. Blood 90, 489-519 (1997).
    • (1997) Blood , vol.90 , pp. 489-519
    • Tenen, D.G.1    Hromas, R.2    Licht, J.D.3    Zhang, D.E.4
  • 2
    • 0034303586 scopus 로고    scopus 로고
    • Diversification of haematopoietic stem cells to specific lineages
    • Orkin, S. H. Diversification of haematopoietic stem cells to specific lineages. Nature Rev. Genet. 1, 57-64 (2000).
    • (2000) Nature Rev. Genet , vol.1 , pp. 57-64
    • Orkin, S.H.1
  • 3
    • 0037315894 scopus 로고    scopus 로고
    • Disruption of differentiation in human cancer: AML shows the way
    • Tenen, D. G. Disruption of differentiation in human cancer: AML shows the way. Nature Rev. Cancer 3, 89-101 (2003).
    • (2003) Nature Rev. Cancer , vol.3 , pp. 89-101
    • Tenen, D.G.1
  • 4
    • 0038406789 scopus 로고    scopus 로고
    • Biology of hematopoietic stem cells and progenitors: Implications for clinical application
    • Kondo, M. et al. Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu. Rev. Immunol. 21, 759-806 (2003).
    • (2003) Annu. Rev. Immunol , vol.21 , pp. 759-806
    • Kondo, M.1
  • 5
    • 0027325195 scopus 로고
    • Differentiation and proliferation of hematopoietic stem cells
    • Ogawa, M. Differentiation and proliferation of hematopoietic stem cells. Blood 81, 2844-2853 (1993).
    • (1993) Blood , vol.81 , pp. 2844-2853
    • Ogawa, M.1
  • 6
    • 0035182533 scopus 로고    scopus 로고
    • Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations
    • Weissman, I. L., Anderson, D. J. & Gage, F. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu. Rev. Cell Dev. Biol. 17, 387-403 (2001).
    • (2001) Annu. Rev. Cell Dev. Biol , vol.17 , pp. 387-403
    • Weissman, I.L.1    Anderson, D.J.2    Gage, F.3
  • 7
    • 0034749999 scopus 로고    scopus 로고
    • + stem cell compartment is accompanied by loss of self-renewal capacity
    • + stem cell compartment is accompanied by loss of self-renewal capacity. Immunity 15, 659-669 (2001).
    • (2001) Immunity , vol.15 , pp. 659-669
    • Adolfsson, J.1
  • 8
    • 0029796633 scopus 로고    scopus 로고
    • Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell
    • Osawa, M., Hanada, K., Hamada, H. & Nakauchi, H. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273, 242-245 (1996).
    • (1996) Science , vol.273 , pp. 242-245
    • Osawa, M.1    Hanada, K.2    Hamada, H.3    Nakauchi, H.4
  • 10
    • 0035807964 scopus 로고    scopus 로고
    • Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells
    • Christensen, J. L. & Weissman, I. L. Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc. Natl Acad. Sci. USA 98, 14541-14546 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 14541-14546
    • Christensen, J.L.1    Weissman, I.L.2
  • 11
    • 33746906644 scopus 로고    scopus 로고
    • Asymmetrical lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors
    • Lai, A. Y. & Kondo, M. Asymmetrical lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors. J. Exp. Med. 203, 1867-1873 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 1867-1873
    • Lai, A.Y.1    Kondo, M.2
  • 12
    • 0030831130 scopus 로고    scopus 로고
    • Identification of clonogenic common lymphoid progenitors in mouse bone marrow
    • Kondo, M., Weissman, I. L. & Akashi, K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91, 661-672 (1997).
    • (1997) Cell , vol.91 , pp. 661-672
    • Kondo, M.1    Weissman, I.L.2    Akashi, K.3
  • 13
    • 0034624828 scopus 로고    scopus 로고
    • Akashi, K., Traver, D., Miyamoto, T. & Weissman, I. L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404, 193-197 (2000). References 12 and 13 are the first reports of prospective isolation of the earliest clonogenic lymphoid- and myeloid-restricted progenitor populations, respectively. The methodologies described in these reports are now widely used.
    • Akashi, K., Traver, D., Miyamoto, T. & Weissman, I. L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404, 193-197 (2000). References 12 and 13 are the first reports of prospective isolation of the earliest clonogenic lymphoid- and myeloid-restricted progenitor populations, respectively. The methodologies described in these reports are now widely used.
  • 14
    • 0037320932 scopus 로고    scopus 로고
    • Thymopoiesis independent of common lymphoid progenitors
    • Allman, D. et al. Thymopoiesis independent of common lymphoid progenitors. Nature Immunol. 4, 168-174 (2003).
    • (2003) Nature Immunol , vol.4 , pp. 168-174
    • Allman, D.1
  • 15
    • 29144472957 scopus 로고    scopus 로고
    • Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis
    • Arinobu, Y. et al. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc. Natl Acad. Sci. USA 102, 18105-18110 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 18105-18110
    • Arinobu, Y.1
  • 16
    • 30344444770 scopus 로고    scopus 로고
    • A clonogenic bone marrow progenitor specific for macrophages and dendritic cells
    • Fogg, D. K. et al. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science 311, 83-87 (2006).
    • (2006) Science , vol.311 , pp. 83-87
    • Fogg, D.K.1
  • 18
    • 13244277736 scopus 로고    scopus 로고
    • Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors
    • Nutt, S. L., Metcalf, D., D'Amico, A., Polli, M. & Wu, L. Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors. J. Exp. Med. 201, 221-231 (2005).
    • (2005) J. Exp. Med , vol.201 , pp. 221-231
    • Nutt, S.L.1    Metcalf, D.2    D'Amico, A.3    Polli, M.4    Wu, L.5
  • 19
    • 15244347369 scopus 로고    scopus 로고
    • Visualizing PU.1 activity during hematopoiesis
    • Back, J., Allman, D., Chan, S. & Kastner, P. Visualizing PU.1 activity during hematopoiesis. Exp. Hematol. 33, 395-402 (2005).
    • (2005) Exp. Hematol , vol.33 , pp. 395-402
    • Back, J.1    Allman, D.2    Chan, S.3    Kastner, P.4
  • 20
    • 20244387299 scopus 로고    scopus 로고
    • + lymphomyeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment
    • + lymphomyeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell 121, 295-306 (2005).
    • (2005) Cell , vol.121 , pp. 295-306
    • Adolfsson, J.1
  • 21
    • 15944363056 scopus 로고    scopus 로고
    • - short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients
    • - short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients. Blood 105, 2717-2723 (2005).
    • (2005) Blood , vol.105 , pp. 2717-2723
    • Yang, L.1
  • 22
    • 33746208874 scopus 로고    scopus 로고
    • + multipotent hematopoietic progenitors. Cell 126, 415-426 (2006). References 20 and 22 are two landmark papers that fundamentally differ in their conclusion on the early precursor hierarchy by which the haematopoietic lineages diversify. They are excellent examples that highlight the fact that despite the great progress made, our understanding on these processes is still incomplete.
    • + multipotent hematopoietic progenitors. Cell 126, 415-426 (2006). References 20 and 22 are two landmark papers that fundamentally differ in their conclusion on the early precursor hierarchy by which the haematopoietic lineages diversify. They are excellent examples that highlight the fact that despite the great progress made, our understanding on these processes is still incomplete.
  • 23
    • 23944446085 scopus 로고    scopus 로고
    • Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation
    • Iwasaki, H. et al. Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation. Blood 106, 1590-1600 (2005).
    • (2005) Blood , vol.106 , pp. 1590-1600
    • Iwasaki, H.1
  • 24
    • 18644373047 scopus 로고    scopus 로고
    • PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis
    • Dakic, A. et al. PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J. Exp. Med. 201, 1487-1502 (2005).
    • (2005) J. Exp. Med , vol.201 , pp. 1487-1502
    • Dakic, A.1
  • 25
    • 0025246676 scopus 로고
    • The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene
    • Klemsz, M. J., McKercher, S. R., Celada, A., van, B. C. & Maki, R. A. The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell 61, 113-124 (1990).
    • (1990) Cell , vol.61 , pp. 113-124
    • Klemsz, M.J.1    McKercher, S.R.2    Celada, A.3    van, B.C.4    Maki, R.A.5
  • 26
    • 0031029557 scopus 로고    scopus 로고
    • Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice
    • Zhang, D. E. et al. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice. Proc. Natl Acad. Sci. USA 94, 569-574 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 569-574
    • Zhang, D.E.1
  • 27
    • 0028853334 scopus 로고
    • Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages
    • Tanaka, T. et al. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 80, 353-361 (1995).
    • (1995) Cell , vol.80 , pp. 353-361
    • Tanaka, T.1
  • 28
    • 0030659176 scopus 로고    scopus 로고
    • Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ε-deficient mice
    • Yamanaka, R. et al. Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ε-deficient mice. Proc. Natl Acad. Sci. USA 94, 13187-13192 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 13187-13192
    • Yamanaka, R.1
  • 29
    • 0037244284 scopus 로고    scopus 로고
    • Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation
    • Hock, H. et al. Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity 18, 109-120 (2003).
    • (2003) Immunity , vol.18 , pp. 109-120
    • Hock, H.1
  • 30
    • 16044369709 scopus 로고    scopus 로고
    • Holtschke, T. et al. Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell 87, 307-317 (1996). The first example of a knockout mouse of a lineage-specific transcription factor developing myeloid leukaemia.
    • Holtschke, T. et al. Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell 87, 307-317 (1996). The first example of a knockout mouse of a lineage-specific transcription factor developing myeloid leukaemia.
  • 31
    • 0030061554 scopus 로고    scopus 로고
    • AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
    • Okuda, T., van, D. J., Hiebert, S. W., Grosveld, G. & Downing, J. R. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84, 321-330 (1996).
    • (1996) Cell , vol.84 , pp. 321-330
    • Okuda, T.1    van, D.J.2    Hiebert, S.W.3    Grosveld, G.4    Downing, J.R.5
  • 32
    • 0028858855 scopus 로고
    • Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
    • Shivdasani, R. A., Mayer, E. L. & Orkin, S. H. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature 373, 432-434 (1995).
    • (1995) Nature , vol.373 , pp. 432-434
    • Shivdasani, R.A.1    Mayer, E.L.2    Orkin, S.H.3
  • 33
    • 0035846912 scopus 로고    scopus 로고
    • Chronic myeloid leukemia with increased granulocyte progenitors in mice lacking junB expression in the myeloid lineage
    • Passegue, E., Jochum, W., Schorpp-Kistner, M., Mohle-Steinlein, U. & Wagner, E. F. Chronic myeloid leukemia with increased granulocyte progenitors in mice lacking junB expression in the myeloid lineage. Cell 104, 21-32 (2001).
    • (2001) Cell , vol.104 , pp. 21-32
    • Passegue, E.1    Jochum, W.2    Schorpp-Kistner, M.3    Mohle-Steinlein, U.4    Wagner, E.F.5
  • 35
    • 0035005526 scopus 로고    scopus 로고
    • c-Myc is a critical target for c/EBPα in granulopoiesis
    • Johansen, L. M. et al. c-Myc is a critical target for c/EBPα in granulopoiesis. Mol. Cell. Biol. 21, 3789-3806 (2001).
    • (2001) Mol. Cell. Biol , vol.21 , pp. 3789-3806
    • Johansen, L.M.1
  • 36
    • 33644641356 scopus 로고    scopus 로고
    • Determinants of lymphoid-myeloid lineage diversification
    • Laiosa, C. V., Stadtfeld, M. & Graf, T. Determinants of lymphoid-myeloid lineage diversification. Annu. Rev. Immunol. 24, 705-738 (2006).
    • (2006) Annu. Rev. Immunol , vol.24 , pp. 705-738
    • Laiosa, C.V.1    Stadtfeld, M.2    Graf, T.3
  • 37
    • 2342451948 scopus 로고    scopus 로고
    • AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis
    • Ichikawa, M. et al. AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nature Med. 10, 299-304 (2004).
    • (2004) Nature Med , vol.10 , pp. 299-304
    • Ichikawa, M.1
  • 38
    • 22144447520 scopus 로고    scopus 로고
    • Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype
    • Growney, J. D. et al. Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Blood 106, 494-504 (2005).
    • (2005) Blood , vol.106 , pp. 494-504
    • Growney, J.D.1
  • 39
    • 0037472895 scopus 로고    scopus 로고
    • Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene
    • Mikkola, H. K. et al. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature 421, 547-551 (2003).
    • (2003) Nature , vol.421 , pp. 547-551
    • Mikkola, H.K.1
  • 40
    • 0028136726 scopus 로고
    • Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
    • Scott, E. W., Simon, M. C., Anastasi, J. & Singh, H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265, 1573-1577 (1994).
    • (1994) Science , vol.265 , pp. 1573-1577
    • Scott, E.W.1    Simon, M.C.2    Anastasi, J.3    Singh, H.4
  • 41
    • 0242549003 scopus 로고    scopus 로고
    • Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
    • McKercher, S. R. et al. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 15, 5647-5658 (1996).
    • (1996) EMBO J , vol.15 , pp. 5647-5658
    • McKercher, S.R.1
  • 42
    • 0030611964 scopus 로고    scopus 로고
    • PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors
    • Scott, E. W. et al. PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Immunity 6, 437-447 (1997).
    • (1997) Immunity , vol.6 , pp. 437-447
    • Scott, E.W.1
  • 43
    • 23944446085 scopus 로고    scopus 로고
    • Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation
    • Iwasaki, H. et al. Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation. Blood 106, 1590-1600 (2005).
    • (2005) Blood , vol.106 , pp. 1590-1600
    • Iwasaki, H.1
  • 44
    • 29444440721 scopus 로고    scopus 로고
    • Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1
    • Rosenbauer, F. et al. Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1. Nature Genet. 38, 27-37 (2006).
    • (2006) Nature Genet , vol.38 , pp. 27-37
    • Rosenbauer, F.1
  • 45
    • 0023839919 scopus 로고
    • Spi-1 is a putative oncogene in virally induced murine erythroleukaemias
    • Moreau-Gachelin, F., Tavitian, A. & Tambourin, P. Spi-1 is a putative oncogene in virally induced murine erythroleukaemias. Nature 331, 277-280 (1988).
    • (1988) Nature , vol.331 , pp. 277-280
    • Moreau-Gachelin, F.1    Tavitian, A.2    Tambourin, P.3
  • 46
    • 0036193609 scopus 로고    scopus 로고
    • Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage
    • Anderson, M. K., Weiss, A. H., Hernandez-Hoyos, G., Dionne, C. J. & Rothenberg, E. V. Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage. Immunity 16, 285-296 (2002).
    • (2002) Immunity , vol.16 , pp. 285-296
    • Anderson, M.K.1    Weiss, A.H.2    Hernandez-Hoyos, G.3    Dionne, C.J.4    Rothenberg, E.V.5
  • 47
    • 0034717335 scopus 로고    scopus 로고
    • Regulation of B lymphocyte and macrophage development by graded expression of PU.1
    • DeKoter, R. P. & Singh, H. Regulation of B lymphocyte and macrophage development by graded expression of PU.1. Science 288, 1439-1441 (2000).
    • (2000) Science , vol.288 , pp. 1439-1441
    • DeKoter, R.P.1    Singh, H.2
  • 48
    • 27944442060 scopus 로고    scopus 로고
    • Ye, M., Ermakova, O. & Graf, T. PU.1 is not strictly required for B cell development and its absence induces a B-2 to B-1 cell switch. J. Exp. Med. 202, 1411-1422 (2005).
    • Ye, M., Ermakova, O. & Graf, T. PU.1 is not strictly required for B cell development and its absence induces a B-2 to B-1 cell switch. J. Exp. Med. 202, 1411-1422 (2005).
  • 49
    • 0142124320 scopus 로고    scopus 로고
    • Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPα ratio and granulocyte colony-stimulating factor
    • Dahl, R. et al. Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPα ratio and granulocyte colony-stimulating factor. Nature Immunol. 4, 1029-1036 (2003).
    • (2003) Nature Immunol , vol.4 , pp. 1029-1036
    • Dahl, R.1
  • 50
    • 2642519463 scopus 로고    scopus 로고
    • Rosenbauer, F. et al. Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1. Nature Genet. 36, 624-630 (2004). The first report showing that AML can be induced by a decrease in the amount of PU.1.
    • Rosenbauer, F. et al. Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1. Nature Genet. 36, 624-630 (2004). The first report showing that AML can be induced by a decrease in the amount of PU.1.
  • 51
    • 0032479989 scopus 로고    scopus 로고
    • DeKoter, R. P., Walsh, J. C. & Singh, H. PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors. EMBO J. 17, 4456-4468 (1998).
    • DeKoter, R. P., Walsh, J. C. & Singh, H. PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors. EMBO J. 17, 4456-4468 (1998).
  • 52
    • 0032170972 scopus 로고    scopus 로고
    • Neutrophils deficient in PU.1 do not terminally differentiate or become functionally competent
    • Anderson, K. L., Smith, K. A., Pio, F., Torbett, B. E. & Maki, R. A. Neutrophils deficient in PU.1 do not terminally differentiate or become functionally competent. Blood 92, 1576-1585 (1998).
    • (1998) Blood , vol.92 , pp. 1576-1585
    • Anderson, K.L.1    Smith, K.A.2    Pio, F.3    Torbett, B.E.4    Maki, R.A.5
  • 53
    • 0031835661 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein α is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors
    • Radomska, H. S. et al. CCAAT/enhancer binding protein α is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol. Cell. Biol. 18, 4301-4314 (1998).
    • (1998) Mol. Cell. Biol , vol.18 , pp. 4301-4314
    • Radomska, H.S.1
  • 54
    • 10344230611 scopus 로고    scopus 로고
    • Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBPα
    • Zhang, P. et al. Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBPα. Immunity 21, 853-863 (2004).
    • (2004) Immunity , vol.21 , pp. 853-863
    • Zhang, P.1
  • 55
    • 21644462493 scopus 로고    scopus 로고
    • Molecular stop signs: Regulation of cell-cycle arrest by C/EBP transcription factors
    • Johnson, P. F. Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors. J. Cell Sci. 118, 2545-2555 (2005).
    • (2005) J. Cell Sci , vol.118 , pp. 2545-2555
    • Johnson, P.F.1
  • 56
    • 2342544921 scopus 로고    scopus 로고
    • Nerlov, C. C/EBPα mutations in acute myeloid leukaemias. Nature Rev. Cancer 4, 394-400 (2004).
    • Nerlov, C. C/EBPα mutations in acute myeloid leukaemias. Nature Rev. Cancer 4, 394-400 (2004).
  • 57
    • 0035913913 scopus 로고    scopus 로고
    • E2F repression by C/EBPα is required for adipogenesis and granulopoiesis in vivo
    • Porse, B. T. et al. E2F repression by C/EBPα is required for adipogenesis and granulopoiesis in vivo. Cell 107, 247-258 (2001).
    • (2001) Cell , vol.107 , pp. 247-258
    • Porse, B.T.1
  • 58
    • 31344466220 scopus 로고    scopus 로고
    • The proline-histidine-rich CDK2/ CDK4 interaction region of C/EBPα is dispensable for C/EBPα-mediated growth regulation in vivo
    • Porse, B. T. et al. The proline-histidine-rich CDK2/ CDK4 interaction region of C/EBPα is dispensable for C/EBPα-mediated growth regulation in vivo. Mol. Cell. Biol. 26, 1028-1037 (2006).
    • (2006) Mol. Cell. Biol , vol.26 , pp. 1028-1037
    • Porse, B.T.1
  • 59
    • 0025292308 scopus 로고
    • An interferon γ-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes
    • Driggers, P. H. et al. An interferon γ-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes. Proc. Natl Acad. Sci. USA 87, 3743-3747 (1990).
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 3743-3747
    • Driggers, P.H.1
  • 60
    • 0033680746 scopus 로고    scopus 로고
    • ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages
    • Tamura, T., Nagamura-Inoue, T., Shmeltzer, Z., Kuwata, T. & Ozato, K. ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages. Immunity 13, 155-165 (2000).
    • (2000) Immunity , vol.13 , pp. 155-165
    • Tamura, T.1    Nagamura-Inoue, T.2    Shmeltzer, Z.3    Kuwata, T.4    Ozato, K.5
  • 61
    • 0032762860 scopus 로고    scopus 로고
    • Interferon consensus sequence binding protein and interferon regulatory factor-4/Pip form a complex that represses the expression of the interferon-stimulated gene-15 in macrophages
    • Rosenbauer, F. et al. Interferon consensus sequence binding protein and interferon regulatory factor-4/Pip form a complex that represses the expression of the interferon-stimulated gene-15 in macrophages. Blood 94, 4274-4281 (1999).
    • (1999) Blood , vol.94 , pp. 4274-4281
    • Rosenbauer, F.1
  • 62
    • 0030664056 scopus 로고    scopus 로고
    • Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction
    • Scharton-Kersten, T., Contursi, C., Masumi, A., Sher, A. & Ozato, K. Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. J. Exp. Med. 186, 1523-1534 (1997).
    • (1997) J. Exp. Med , vol.186 , pp. 1523-1534
    • Scharton-Kersten, T.1    Contursi, C.2    Masumi, A.3    Sher, A.4    Ozato, K.5
  • 63
    • 0030670801 scopus 로고    scopus 로고
    • Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression
    • Giese, N. A. et al. Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression. J. Exp. Med. 186, 1535-1546 (1997).
    • (1997) J. Exp. Med , vol.186 , pp. 1535-1546
    • Giese, N.A.1
  • 64
    • 0033485888 scopus 로고    scopus 로고
    • Altered development and cytokine responses of myeloid progenitors in the absence of transcription factor, interferon consensus sequence binding protein
    • Scheller, M. et al. Altered development and cytokine responses of myeloid progenitors in the absence of transcription factor, interferon consensus sequence binding protein. Blood 94, 3764-3771 (1999).
    • (1999) Blood , vol.94 , pp. 3764-3771
    • Scheller, M.1
  • 65
    • 0036566543 scopus 로고    scopus 로고
    • Accumulation of c-Cbl and rapid termination of colony-stimulating factor 1 receptor signaling in interferon consensus sequence binding protein-deficient bone marrow-derived macrophages
    • Kallies, A., Rosenbauer, F., Scheller, M., Knobeloch, K. P. & Horak, I. Accumulation of c-Cbl and rapid termination of colony-stimulating factor 1 receptor signaling in interferon consensus sequence binding protein-deficient bone marrow-derived macrophages. Blood 99, 3213-3219 (2002).
    • (2002) Blood , vol.99 , pp. 3213-3219
    • Kallies, A.1    Rosenbauer, F.2    Scheller, M.3    Knobeloch, K.P.4    Horak, I.5
  • 66
    • 33747196725 scopus 로고    scopus 로고
    • Multilineage transcriptional priming and determination of alternate hematopoietic cell fates
    • Laslo, P. et al. Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell 126, 755-766 (2006).
    • (2006) Cell , vol.126 , pp. 755-766
    • Laslo, P.1
  • 67
    • 0029897536 scopus 로고    scopus 로고
    • Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor
    • Zweidler-McKay, P. A., Grimes, H. L., Flubacher, M. M. & Tsichlis, P. N. Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor. Mol. Cell. Biol. 16, 4024-4034 (1996).
    • (1996) Mol. Cell. Biol , vol.16 , pp. 4024-4034
    • Zweidler-McKay, P.A.1    Grimes, H.L.2    Flubacher, M.M.3    Tsichlis, P.N.4
  • 68
    • 85047697279 scopus 로고    scopus 로고
    • High levels of the onco-protein Gfi-1 accelerate T-cell proliferation and inhibit activation induced T-cell death in Jurkat T-cells
    • Karsunky, H., Mende, I., Schmidt, T. & Moroy, T. High levels of the onco-protein Gfi-1 accelerate T-cell proliferation and inhibit activation induced T-cell death in Jurkat T-cells. Oncogene 21, 1571-1579 (2002).
    • (2002) Oncogene , vol.21 , pp. 1571-1579
    • Karsunky, H.1    Mende, I.2    Schmidt, T.3    Moroy, T.4
  • 69
    • 33644843788 scopus 로고    scopus 로고
    • Zinc-finger transcription factor Gfi-1: Versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells
    • Hock, H. & Orkin, S. H. Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells. Curr. Opin. Hematol. 13, 1-6 (2006).
    • (2006) Curr. Opin. Hematol , vol.1 , Issue.3 , pp. 1-6
    • Hock, H.1    Orkin, S.H.2
  • 70
    • 0036510161 scopus 로고    scopus 로고
    • Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1
    • Karsunky, H. et al. Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1. Nature Genet. 30, 295-300 (2002).
    • (2002) Nature Genet , vol.30 , pp. 295-300
    • Karsunky, H.1
  • 71
    • 8144220648 scopus 로고    scopus 로고
    • Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells
    • Zeng, H., Yucel, R., Kosan, C., Klein-Hitpass, L. & Moroy, T. Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J. 23, 4116-4125 (2004).
    • (2004) EMBO J , vol.23 , pp. 4116-4125
    • Zeng, H.1    Yucel, R.2    Kosan, C.3    Klein-Hitpass, L.4    Moroy, T.5
  • 72
    • 7244231429 scopus 로고    scopus 로고
    • Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells
    • Hock, H. et al. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature 431, 1002-1007 (2004).
    • (2004) Nature , vol.431 , pp. 1002-1007
    • Hock, H.1
  • 73
    • 0029001407 scopus 로고
    • Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B
    • Chen, H. M. et al. Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B. Blood 85, 2918-2928 (1995).
    • (1995) Blood , vol.85 , pp. 2918-2928
    • Chen, H.M.1
  • 74
    • 0036566050 scopus 로고    scopus 로고
    • Spi-B can functionally replace PU.1 in myeloid but not lymphoid development
    • Dahl, R., Ramirez-Bergeron, D. L., Rao, S. & Simon, M. C. Spi-B can functionally replace PU.1 in myeloid but not lymphoid development. EMBO J. 21, 2220-2230 (2002).
    • (2002) EMBO J , vol.21 , pp. 2220-2230
    • Dahl, R.1    Ramirez-Bergeron, D.L.2    Rao, S.3    Simon, M.C.4
  • 75
    • 0037085568 scopus 로고    scopus 로고
    • Expression of C/EBPβ from the C/ebpα gene locus is sufficient for normal hematopoiesis in vivo
    • Jones, L. C. et al. Expression of C/EBPβ from the C/ebpα gene locus is sufficient for normal hematopoiesis in vivo. Blood 99, 2032-2036 (2002).
    • (2002) Blood , vol.99 , pp. 2032-2036
    • Jones, L.C.1
  • 76
    • 33745225494 scopus 로고    scopus 로고
    • C/EBPβ is required for ' emergency' granulopoiesis
    • Hirai, H. et al. C/EBPβ is required for ' emergency' granulopoiesis. Nature Immunol. 7, 732-739 (2006).
    • (2006) Nature Immunol , vol.7 , pp. 732-739
    • Hirai, H.1
  • 77
    • 0035892121 scopus 로고    scopus 로고
    • Regulation of the PU.1 gene by distal elements
    • Li, Y. et al. Regulation of the PU.1 gene by distal elements. Blood 98, 2958-2965 (2001).
    • (2001) Blood , vol.98 , pp. 2958-2965
    • Li, Y.1
  • 78
    • 20144368117 scopus 로고    scopus 로고
    • Potential autoregulation of transcription factor PU.1 by an upstream regulatory element
    • Okuno, Y. et al. Potential autoregulation of transcription factor PU.1 by an upstream regulatory element. Mol. Cell. Biol. 25, 2832-2845 (2005).
    • (2005) Mol. Cell. Biol , vol.25 , pp. 2832-2845
    • Okuno, Y.1
  • 79
    • 0036110293 scopus 로고    scopus 로고
    • Transcriptional regulation of the stem cell leukemia gene (SCL) - comparative analysis of five vertebrate SCL loci
    • Gottgens, B. et al. Transcriptional regulation of the stem cell leukemia gene (SCL) - comparative analysis of five vertebrate SCL loci. Genome Res. 12, 749-759 (2002).
    • (2002) Genome Res , vol.12 , pp. 749-759
    • Gottgens, B.1
  • 80
    • 0032789064 scopus 로고    scopus 로고
    • Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene
    • Vyas, P. et al. Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene. Development 126, 2799-2811 (1999).
    • (1999) Development , vol.126 , pp. 2799-2811
    • Vyas, P.1
  • 81
    • 2942526253 scopus 로고    scopus 로고
    • The scl + 18/19 stem cell enhancer is not required for hematopoiesis: Identification of a 5′ bifunctional hematopoieticendothelial enhancer bound by Fli-1 and Elf-1
    • Gottgens, B. et al. The scl + 18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5′ bifunctional hematopoieticendothelial enhancer bound by Fli-1 and Elf-1. Mol. Cell. Biol. 24, 1870-1883 (2004).
    • (2004) Mol. Cell. Biol , vol.24 , pp. 1870-1883
    • Gottgens, B.1
  • 82
    • 0036892346 scopus 로고    scopus 로고
    • Translational control of gene expression and disease
    • Calkhoven, C. F., Muller, C. & Leutz, A. Translational control of gene expression and disease. Trends Mol. Med. 8, 577-583 (2002).
    • (2002) Trends Mol. Med , vol.8 , pp. 577-583
    • Calkhoven, C.F.1    Muller, C.2    Leutz, A.3
  • 83
    • 0035093813 scopus 로고    scopus 로고
    • Pabst, T. et al. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia. Nature Genet. 27, 263-270 (2001). The first report of CEBPA mutations in patients with AML. It also describes a dominant-negative mechanism that could explain how the mutation of one allele could inhibit the differentiation function of the other (wild-type) allele.
    • Pabst, T. et al. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia. Nature Genet. 27, 263-270 (2001). The first report of CEBPA mutations in patients with AML. It also describes a dominant-negative mechanism that could explain how the mutation of one allele could inhibit the differentiation function of the other (wild-type) allele.
  • 84
    • 0033869876 scopus 로고    scopus 로고
    • Translational control of C/EBPα and C/EBPβ isoform expression
    • Calkhoven, C. F., Muller, C. & Leutz, A. Translational control of C/EBPα and C/EBPβ isoform expression. Genes Dev. 14, 1920-1932 (2000).
    • (2000) Genes Dev , vol.14 , pp. 1920-1932
    • Calkhoven, C.F.1    Muller, C.2    Leutz, A.3
  • 85
    • 0344080625 scopus 로고    scopus 로고
    • Calkhoven, C. F. et al. Translational control of SCL-isoform expression in hematopoietic lineage choice. Genes Dev. 17, 959-964 (2003). References 84 and 85 show another mechanism for transcription factor tuning; through varying protein isoform expression, as controlled by small sequence motifs in the untranslated upstream open-reading frames.
    • Calkhoven, C. F. et al. Translational control of SCL-isoform expression in hematopoietic lineage choice. Genes Dev. 17, 959-964 (2003). References 84 and 85 show another mechanism for transcription factor tuning; through varying protein isoform expression, as controlled by small sequence motifs in the untranslated upstream open-reading frames.
  • 86
    • 0347356374 scopus 로고    scopus 로고
    • Phosphorylation of C/EBPα inhibits granulopoiesis
    • Ross, S. E. et al. Phosphorylation of C/EBPα inhibits granulopoiesis. Mol. Cell. Biol. 24, 675-686 (2004).
    • (2004) Mol. Cell. Biol , vol.24 , pp. 675-686
    • Ross, S.E.1
  • 87
    • 16744363992 scopus 로고    scopus 로고
    • Ras signaling enhances the activity of C/EBPα to induce granulocytic differentiation by phosphorylation of serine 248
    • Behre, G. et al. Ras signaling enhances the activity of C/EBPα to induce granulocytic differentiation by phosphorylation of serine 248. J. Biol. Chem. 277, 26293-26299 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 26293-26299
    • Behre, G.1
  • 88
    • 0033151624 scopus 로고    scopus 로고
    • Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: Functional antagonism in erythroid cells
    • Rekhtman, N., Radparvar, F., Evans, T. & Skoultchi, A. I. Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. Genes Dev. 13, 1398-1411 (1999).
    • (1999) Genes Dev , vol.13 , pp. 1398-1411
    • Rekhtman, N.1    Radparvar, F.2    Evans, T.3    Skoultchi, A.I.4
  • 89
    • 0033587755 scopus 로고    scopus 로고
    • Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1
    • Zhang, P. et al. Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. Proc. Natl Acad. Sci. USA 96, 8705-8710 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 8705-8710
    • Zhang, P.1
  • 90
    • 27744587735 scopus 로고    scopus 로고
    • Stopka, T., Amanatullah, D. F., Papetti, M. & Skoultchi, A. I. PU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure. EMBO J. 24, 3712-3723 (2005).
    • Stopka, T., Amanatullah, D. F., Papetti, M. & Skoultchi, A. I. PU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure. EMBO J. 24, 3712-3723 (2005).
  • 91
    • 0031030682 scopus 로고    scopus 로고
    • Deregulated expression of the PU.1 transcription factor blocks murine erythroleukemia cell terminal differentiation
    • Rao, G., Rekhtman, N., Cheng, G., Krasikov, T. & Skoultchi, A. I. Deregulated expression of the PU.1 transcription factor blocks murine erythroleukemia cell terminal differentiation. Oncogene 14, 123-131 (1997).
    • (1997) Oncogene , vol.14 , pp. 123-131
    • Rao, G.1    Rekhtman, N.2    Cheng, G.3    Krasikov, T.4    Skoultchi, A.I.5
  • 92
    • 0030047739 scopus 로고    scopus 로고
    • Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: Regulation of multiple myeloid CSF receptor promoters
    • Zhang, D. E. et al. Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: regulation of multiple myeloid CSF receptor promoters. Curr. Top. Microbiol. Immunol. 211, 137-147 (1996).
    • (1996) Curr. Top. Microbiol. Immunol , vol.211 , pp. 137-147
    • Zhang, D.E.1
  • 93
    • 0141483064 scopus 로고    scopus 로고
    • Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
    • Passegue, E., Jamieson, C. H., Ailles, L. E. & Weissman, I. L. Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc. Natl Acad. Sci. USA 100 (Suppl. 1), 11842-11849 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , Issue.SUPPL. 1 , pp. 11842-11849
    • Passegue, E.1    Jamieson, C.H.2    Ailles, L.E.3    Weissman, I.L.4
  • 94
    • 0030658039 scopus 로고    scopus 로고
    • Oncogenic transcription factors in the human acute leukemias
    • Look, A. T. Oncogenic transcription factors in the human acute leukemias. Science 278, 1059-1064 (1997).
    • (1997) Science , vol.278 , pp. 1059-1064
    • Look, A.T.1
  • 95
    • 15044358998 scopus 로고    scopus 로고
    • CEBPA point mutations in hematological malignancies
    • Leroy, H. et al. CEBPA point mutations in hematological malignancies. Leukemia 19, 329-334 (2005).
    • (2005) Leukemia , vol.19 , pp. 329-334
    • Leroy, H.1
  • 96
    • 0036727413 scopus 로고    scopus 로고
    • Wechsler, J. et al. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome. Nature Genet. 32, 148-152 (2002). This paper shows for the first time that acute megakaryoblastic leukaemia associated with Down's syndrome is related to N-terminal mutations in GATA1 that lead to a dominant-negative allele, analogous to CEBPA mutations in the AML FAB system subtype 2.
    • Wechsler, J. et al. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome. Nature Genet. 32, 148-152 (2002). This paper shows for the first time that acute megakaryoblastic leukaemia associated with Down's syndrome is related to N-terminal mutations in GATA1 that lead to a dominant-negative allele, analogous to CEBPA mutations in the AML FAB system subtype 2.
  • 97
    • 10044294000 scopus 로고    scopus 로고
    • GATA1 mutations in Down syndrome: Implications for biology and diagnosis of children with transient myeloproliferative disorder and acute megakaryoblastic leukemia
    • Crispino, J. D. GATA1 mutations in Down syndrome: implications for biology and diagnosis of children with transient myeloproliferative disorder and acute megakaryoblastic leukemia. Pediatr. Blood Cancer 44, 40-44 (2005).
    • (2005) Pediatr. Blood Cancer , vol.44 , pp. 40-44
    • Crispino, J.D.1
  • 98
    • 0029558618 scopus 로고
    • Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor
    • Calligaris, R., Bottardi, S., Cogoi, S., Apezteguia, I. & Santoro, C. Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor. Proc. Natl Acad. Sci. USA 92, 11598-11602 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 11598-11602
    • Calligaris, R.1    Bottardi, S.2    Cogoi, S.3    Apezteguia, I.4    Santoro, C.5
  • 99
    • 0942287758 scopus 로고    scopus 로고
    • Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome
    • Gurbuxani, S., Vyas, P. & Crispino, J. D. Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome. Blood 103, 399-406 (2004).
    • (2004) Blood , vol.103 , pp. 399-406
    • Gurbuxani, S.1    Vyas, P.2    Crispino, J.D.3
  • 100
    • 20044381309 scopus 로고    scopus 로고
    • Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1
    • Li, Z. et al. Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nature Genet. 37, 613-619 (2005).
    • (2005) Nature Genet , vol.37 , pp. 613-619
    • Li, Z.1
  • 101
    • 0035047652 scopus 로고    scopus 로고
    • AML1-ETO downregulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia
    • Pabst, T. et al. AML1-ETO downregulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia. Nature Med. 7, 444-451 (2001).
    • (2001) Nature Med , vol.7 , pp. 444-451
    • Pabst, T.1
  • 102
    • 0037944120 scopus 로고    scopus 로고
    • Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations
    • Mizuki, M. et al. Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations. Blood 101, 3164-3173 (2003).
    • (2003) Blood , vol.101 , pp. 3164-3173
    • Mizuki, M.1
  • 103
    • 1442307974 scopus 로고    scopus 로고
    • Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPα expression
    • Zheng, R. et al. Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPα expression. Blood 103, 1883-1890 (2004).
    • (2004) Blood , vol.103 , pp. 1883-1890
    • Zheng, R.1
  • 104
    • 33344455424 scopus 로고    scopus 로고
    • Block of C/EBPα function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations
    • Radomska, H. S. et al. Block of C/EBPα function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations. J. Exp. Med. 203, 371-381 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 371-381
    • Radomska, H.S.1
  • 105
    • 0036340784 scopus 로고    scopus 로고
    • BCR-ABL suppresses C/EBPα expression through inhibitory action of hnRNP E2
    • Perrotti, D. et al. BCR-ABL suppresses C/EBPα expression through inhibitory action of hnRNP E2. Nature Genet. 30, 48-58 (2002).
    • (2002) Nature Genet , vol.30 , pp. 48-58
    • Perrotti, D.1
  • 106
    • 22344437854 scopus 로고    scopus 로고
    • Loss of C/EBPα cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage
    • Porse, B. T. et al. Loss of C/EBPα cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage. J. Exp. Med. 202, 85-96 (2005).
    • (2005) J. Exp. Med , vol.202 , pp. 85-96
    • Porse, B.T.1
  • 107
    • 33646589342 scopus 로고    scopus 로고
    • Absence of the transcription factor CCAAT enhancer binding protein α results in loss of myeloid identity in bcr/abl-induced malignancy
    • Wagner, K. et al. Absence of the transcription factor CCAAT enhancer binding protein α results in loss of myeloid identity in bcr/abl-induced malignancy. Proc. Natl Acad. Sci. USA 103, 6338-6343 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 6338-6343
    • Wagner, K.1
  • 108
    • 0033559746 scopus 로고    scopus 로고
    • Osato, M. et al. Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2αB gene associated with myeloblastic leukemias. Blood 93, 1817-1824 (1999). This study shows that RUNX1 could be involved in the pathogenesis of AML through a mechanism other than translocation, and that RUNX1 mutations were associated with a distinct differentiation subtype of AML.
    • Osato, M. et al. Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2αB gene associated with myeloblastic leukemias. Blood 93, 1817-1824 (1999). This study shows that RUNX1 could be involved in the pathogenesis of AML through a mechanism other than translocation, and that RUNX1 mutations were associated with a distinct differentiation subtype of AML.
  • 109
    • 0031964844 scopus 로고    scopus 로고
    • Lack of interferon consensus sequence binding protein (ICSBP) transcripts in human myeloid leukemias
    • Schmidt, M. et al. Lack of interferon consensus sequence binding protein (ICSBP) transcripts in human myeloid leukemias. Blood 91, 22-29 (1998).
    • (1998) Blood , vol.91 , pp. 22-29
    • Schmidt, M.1
  • 110
    • 0033956688 scopus 로고    scopus 로고
    • Expression of interferon consensus sequence binding protein (ICSBP) is downregulated in Bcr-Abl-induced murine chronic myelogenous leukemia-like disease, and forced coexpression of ICSBP inhibits Bcr-Abl-induced myeloproliferative disorder
    • Hao, S. X. & Ren, R. Expression of interferon consensus sequence binding protein (ICSBP) is downregulated in Bcr-Abl-induced murine chronic myelogenous leukemia-like disease, and forced coexpression of ICSBP inhibits Bcr-Abl-induced myeloproliferative disorder. Mol. Cell. Biol. 20, 1149-1161 (2000).
    • (2000) Mol. Cell. Biol , vol.20 , pp. 1149-1161
    • Hao, S.X.1    Ren, R.2
  • 111
    • 0037020837 scopus 로고    scopus 로고
    • AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency
    • Schwieger, M. et al. AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency. J. Exp. Med. 196, 1227-1240 (2002).
    • (2002) J. Exp. Med , vol.196 , pp. 1227-1240
    • Schwieger, M.1
  • 112
    • 17144424686 scopus 로고    scopus 로고
    • A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia-like syndrome in BXH-2 mice
    • Turcotte, K. et al. A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia-like syndrome in BXH-2 mice. J. Exp. Med. 201, 881-890 (2005).
    • (2005) J. Exp. Med , vol.201 , pp. 881-890
    • Turcotte, K.1
  • 113
    • 0036682473 scopus 로고    scopus 로고
    • Heterozygous PU.1 mutations are associated with acute myeloid leukemia
    • Mueller, B. U. et al. Heterozygous PU.1 mutations are associated with acute myeloid leukemia. Blood 100, 998-1007 (2002).
    • (2002) Blood , vol.100 , pp. 998-1007
    • Mueller, B.U.1
  • 114
    • 0242662157 scopus 로고    scopus 로고
    • Mutation analysis of the transcription factor PU.1 in younger adults (16 to 60 years) with acute myeloid leukemia: A study of the AML Study Group Ulm (AMLSG ULM)
    • Dohner, K. et al. Mutation analysis of the transcription factor PU.1 in younger adults (16 to 60 years) with acute myeloid leukemia: a study of the AML Study Group Ulm (AMLSG ULM). Blood 102, 3850-3851 (2003).
    • (2003) Blood , vol.102 , pp. 3850-3851
    • Dohner, K.1
  • 115
    • 0037114703 scopus 로고    scopus 로고
    • Are PU.1 mutations frequent genetic events in acute myeloid leukemia (AML)?
    • Lamandin, C. et al. Are PU.1 mutations frequent genetic events in acute myeloid leukemia (AML)? Blood 100, 4680-4681 (2002).
    • (2002) Blood , vol.100 , pp. 4680-4681
    • Lamandin, C.1
  • 116
    • 0037222293 scopus 로고    scopus 로고
    • The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia
    • Vangala, R. K. et al. The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia. Blood 101, 270-277 (2003).
    • (2003) Blood , vol.101 , pp. 270-277
    • Vangala, R.K.1
  • 117
    • 33645734361 scopus 로고    scopus 로고
    • ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression
    • Mueller, B. U. et al. ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression. Blood 107, 3330-3338 (2005).
    • (2005) Blood , vol.107 , pp. 3330-3338
    • Mueller, B.U.1
  • 118
    • 9444287619 scopus 로고    scopus 로고
    • PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain
    • Cook, W. D. et al. PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain. Blood 104, 3437-3444 (2004).
    • (2004) Blood , vol.104 , pp. 3437-3444
    • Cook, W.D.1
  • 119
    • 19944418810 scopus 로고    scopus 로고
    • Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukaemia
    • Suraweera, N. et al. Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukaemia. Oncogene 24, 3678-3683 (2005).
    • (2005) Oncogene , vol.24 , pp. 3678-3683
    • Suraweera, N.1
  • 120
    • 24644482422 scopus 로고    scopus 로고
    • Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARα
    • Walter, M. J. et al. Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARα. Proc. Natl Acad. Sci. USA 102, 12513-12518 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 12513-12518
    • Walter, M.J.1
  • 121
    • 23944471175 scopus 로고    scopus 로고
    • Effect of transcription-factor concentrations on leukemic stem cells
    • Rosenbauer, F., Koschmieder, S., Steidl, U. & Tenen, D. G. Effect of transcription-factor concentrations on leukemic stem cells. Blood 106, 1519-1524 (2005).
    • (2005) Blood , vol.106 , pp. 1519-1524
    • Rosenbauer, F.1    Koschmieder, S.2    Steidl, U.3    Tenen, D.G.4
  • 122
    • 31944450531 scopus 로고    scopus 로고
    • Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia
    • Metcalf, D. et al. Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia. Proc. Natl Acad. Sci. USA 103, 1486-1491 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 1486-1491
    • Metcalf, D.1
  • 123
    • 0025029192 scopus 로고
    • Homeobox gene expression plus autocrine growth factor production elicits myeloid leukemia
    • Perkins, A., Kongsuwan, K., Visvader, J., Adams, J. M. & Cory, S. Homeobox gene expression plus autocrine growth factor production elicits myeloid leukemia. Proc. Natl Acad. Sci. USA 87, 8398-8402 (1990).
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 8398-8402
    • Perkins, A.1    Kongsuwan, K.2    Visvader, J.3    Adams, J.M.4    Cory, S.5
  • 124
    • 33751196596 scopus 로고    scopus 로고
    • Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia
    • Chapiro, E. et al. Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia. Blood 108, 3560-3563 (2006).
    • (2006) Blood , vol.108 , pp. 3560-3563
    • Chapiro, E.1
  • 125
    • 6044269157 scopus 로고    scopus 로고
    • Self-renewal of teratocarcinoma and embryonic stem cells
    • Chambers, I. & Smith, A. Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene 23, 7150-7160 (2004).
    • (2004) Oncogene , vol.23 , pp. 7150-7160
    • Chambers, I.1    Smith, A.2
  • 126
    • 0037108111 scopus 로고    scopus 로고
    • Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: A study from the Acute Leukemia French Association (ALFA)
    • Preudhomme, C. et al. Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA). Blood 100, 2717-2723 (2002).
    • (2002) Blood , vol.100 , pp. 2717-2723
    • Preudhomme, C.1
  • 127
    • 0242389807 scopus 로고    scopus 로고
    • Duprez, E., Wagner, K., Koch, H. & Tenen, D. G. C/EBPβ: a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells. EMBO J. 22, 5806-5816 (2003).
    • Duprez, E., Wagner, K., Koch, H. & Tenen, D. G. C/EBPβ: a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells. EMBO J. 22, 5806-5816 (2003).
  • 128
    • 0037307675 scopus 로고    scopus 로고
    • CCAAT/enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia
    • Truong, B. T. et al. CCAAT/enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia. Blood 101, 1141-1148 (2003).
    • (2003) Blood , vol.101 , pp. 1141-1148
    • Truong, B.T.1
  • 129
    • 33749317297 scopus 로고    scopus 로고
    • CCAAT/enhancer binding proteins α and ε cooperate with all-trans retinoic acid in therapy but they differ in their anti-leukemic activities
    • Lee, Y. J. et al. CCAAT/enhancer binding proteins α and ε cooperate with all-trans retinoic acid in therapy but they differ in their anti-leukemic activities. Blood 108, 2416-2419 (2006).
    • (2006) Blood , vol.108 , pp. 2416-2419
    • Lee, Y.J.1
  • 130
    • 0037816153 scopus 로고    scopus 로고
    • Specific protein redirection as a transcriptional therapy approach for t(8;21) leukemia
    • Steffen, B. et al. Specific protein redirection as a transcriptional therapy approach for t(8;21) leukemia. Proc. Natl Acad. Sci. USA 100, 8448-8453 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 8448-8453
    • Steffen, B.1
  • 131
    • 0344413639 scopus 로고    scopus 로고
    • Krosl, J. et al. In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein. Nature Med. 9, 1428-1432 (2003). References 130 and 131 are two elegant studies showing possible ways to design and deliver drugs to modulate transcription factors in cells from cancer patients.
    • Krosl, J. et al. In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein. Nature Med. 9, 1428-1432 (2003). References 130 and 131 are two elegant studies showing possible ways to design and deliver drugs to modulate transcription factors in cells from cancer patients.
  • 132
    • 3943086381 scopus 로고    scopus 로고
    • Complementation of α-thalassaemia in α-globin knockout mice with a 191 kb transgene containing the human α-globin locus
    • Al-Hasani, K., Vadolas, J., Voullaire, L., Williamson, R. & Ioannou, P. A. Complementation of α-thalassaemia in α-globin knockout mice with a 191 kb transgene containing the human α-globin locus. Transgenic Res. 13, 235-243 (2004).
    • (2004) Transgenic Res , vol.13 , pp. 235-243
    • Al-Hasani, K.1    Vadolas, J.2    Voullaire, L.3    Williamson, R.4    Ioannou, P.A.5
  • 133
    • 0029121271 scopus 로고
    • Absence of yolk sac hematopoiesis from mice with a targeted disruption of the Scl gene
    • Robb, L. et al. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the Scl gene. Proc. Natl Acad. Sci. USA 92, 7075-7079 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 7075-7079
    • Robb, L.1
  • 134
    • 0037417892 scopus 로고    scopus 로고
    • The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12
    • Hall, M. A. et al. The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc. Natl Acad. Sci. USA 100, 992-997 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 992-997
    • Hall, M.A.1
  • 135
    • 1942425445 scopus 로고    scopus 로고
    • SCL is required for normal function of short-term repopulating hematopoietic stem cells
    • Curtis, D. J. et al. SCL is required for normal function of short-term repopulating hematopoietic stem cells. Blood 103, 3342-3348 (2004).
    • (2004) Blood , vol.103 , pp. 3342-3348
    • Curtis, D.J.1
  • 136
    • 0033231036 scopus 로고    scopus 로고
    • Myeloid transcription factor C/EBPε is involved in the positive regulation of lactoferrin gene expression in neutrophils
    • Verbeek, W. et al. Myeloid transcription factor C/EBPε is involved in the positive regulation of lactoferrin gene expression in neutrophils. Blood 94, 3141-3150 (1999).
    • (1999) Blood , vol.94 , pp. 3141-3150
    • Verbeek, W.1
  • 137
    • 0036636857 scopus 로고    scopus 로고
    • Core-binding factors in haematopoiesis and leukaemia
    • Speck, N. A. & Gilliland, D. G. Core-binding factors in haematopoiesis and leukaemia. Nature Rev. Cancer 2, 502-513 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 502-513
    • Speck, N.A.1    Gilliland, D.G.2
  • 138
    • 0033561797 scopus 로고    scopus 로고
    • Deconstructing a disease: RARα, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia
    • Melnick, A. & Licht, J. D. Deconstructing a disease: RARα, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood 93, 3167-3215 (1999).
    • (1999) Blood , vol.93 , pp. 3167-3215
    • Melnick, A.1    Licht, J.D.2
  • 139
    • 0035839952 scopus 로고    scopus 로고
    • Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins
    • Ayton, P. M. & Cleary, M. L. Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins. Oncogene 20, 5695-5707 (2001).
    • (2001) Oncogene , vol.20 , pp. 5695-5707
    • Ayton, P.M.1    Cleary, M.L.2
  • 140
    • 12344325677 scopus 로고    scopus 로고
    • Crispino, J. D. GATA1 in normal and malignant hematopoiesis. Semin. Cell Dev. Biol. 16, 137-147 (2005).
    • Crispino, J. D. GATA1 in normal and malignant hematopoiesis. Semin. Cell Dev. Biol. 16, 137-147 (2005).
  • 141
    • 0141593492 scopus 로고    scopus 로고
    • Down-modulation of the C/EBPα transcription factor in core binding factor acute myeloid leukemias
    • Cilloni, D. et al. Down-modulation of the C/EBPα transcription factor in core binding factor acute myeloid leukemias. Blood 102, 2705-2706 (2003).
    • (2003) Blood , vol.102 , pp. 2705-2706
    • Cilloni, D.1
  • 142
    • 33845355846 scopus 로고    scopus 로고
    • JAK-2 mutations and their relevance to myeloproliferative disease
    • Levine, R. L. & Gilliland, D. G. JAK-2 mutations and their relevance to myeloproliferative disease. Curr. Opin. Hematol. 14, 43-47 (2007).
    • (2007) Curr. Opin. Hematol , vol.14 , pp. 43-47
    • Levine, R.L.1    Gilliland, D.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.