MiR-155 as a multiple sclerosis-relevant regulator of myeloid cell polarization

Annals of Neurology

Volumn 74, Issue 5, 2013, Pages 709-720

  Moore, Craig S ^a   Rao, Vijayaraghava T S ^a   Durafourt, Bryce A ^a   Bedell, Barry J ^a   Ludwin, Samuel K ^b   Bar Or, Amit ^a   Antel, Jack P ^a  

^a MCGILL UNIVERSITY   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD68 ANTIGEN; MICRORNA; MICRORNA 124A; MICRORNA 132; MICRORNA 146A; MICRORNA 155; SUPPRESSOR OF CYTOKINE SIGNALING 1; UNCLASSIFIED DRUG;

ARTICLE; BONE MARROW CELL; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENETIC TRANSFECTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INNATE IMMUNITY; LASER CAPTURE MICRODISSECTION; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MICROGLIA; MONOCYTE; MULTIPLE SCLEROSIS; PHENOTYPE; POLARIZATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA ISOLATION;

EID: 84890804750     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.23967     Document Type: Article

References (48)

1. Durafourt BA, Moore CS, Zammit DA, et al. Comparison of polarization properties of human adult microglia and blood-derived macrophages. Glia 2012; 60: 717-727.
2. Jack CS, Arbour N, Manusow J, et al. TLR signaling tailors innate immune responses in human microglia and astrocytes. J Immunol 2005; 175: 4320-4330.
3. Jack CS, Arbour N, Blain M, et al. Th1 polarization of CD4+ T cells by Toll-like receptor 3-activated human microglia. J Neuropathol Exp Neurol 2007; 66: 848-859.
4. Lambert C, Ase AR, Seguela P, Antel JP,. Distinct migratory and cytokine responses of human microglia and macrophages to ATP. Brain Behav Immun 2010; 24: 1241-1248.
5. Rodriguez A, Griffiths-Jones S, Ashurst JL, Bradley A,. Identification of mammalian microRNA host genes and transcription units. Genome Res 2004; 14: 1902-1910.
6. Yeom KH, Lee Y, Han J, et al. Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing. Nucleic Acids Res 2006; 34: 4622-4629.
7. Ceribelli A, Nahid MA, Satoh M, Chan EK,. MicroRNAs in rheumatoid arthritis. FEBS Lett 2011; 585: 3667-3674.
8. Wang H, Peng W, Ouyang X, et al. Circulating microRNAs as candidate biomarkers in patients with systemic lupus erythematosus. Transl Res 2012; 160: 198-206.
9. Guerau-de-Arellano M, Alder H, Ozer HG, et al. miRNA profiling for biomarker discovery in multiple sclerosis: from microarray to deep sequencing. J Neuroimmunol 2012; 248: 32-39.
10. Guerau-de-Arellano M, Smith KM, Godlewski J, et al. Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity. Brain 2011; 134 (pt 12): 3578-3589.
11. Banerjee A, Schambach F, DeJong CS, et al. Micro-RNA-155 inhibits IFN-gamma signaling in CD4+ T cells. Eur J Immunol 2010; 40: 225-231.
12. Ponomarev ED, Veremeyko T, Weiner HL,. MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS. Glia 2013; 61: 91-103.
13. Lescher J, Paap F, Schultz V, et al. MicroRNA regulation in experimental autoimmune encephalomyelitis in mice and marmosets resembles regulation in human multiple sclerosis lesions. J Neuroimmunol 2012; 246: 27-33.
14. Junker A, Krumbholz M, Eisele S, et al. MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain 2009; 132 (pt 12): 3342-3352.
15. Noorbakhsh F, Ellestad KK, Maingat F, et al. Impaired neurosteroid synthesis in multiple sclerosis. Brain 2011; 134 (pt 9): 2703-2721.
16. Cox MB, Cairns MJ, Gandhi KS, et al. MicroRNAs miR-17 and miR-20a inhibit T cell activation genes and are under-expressed in MS whole blood. PLoS One 2010; 5: e12132.
17. Siegel SR, Mackenzie J, Chaplin G, et al. Circulating microRNAs involved in multiple sclerosis. Mol Biol Rep 2012; 39: 6219-6225.
18. Keller A, Leidinger P, Lange J, et al. Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controls. PLoS One 2009; 4: e7440.
19. Martinelli-Boneschi F, Fenoglio C, Brambilla P, et al. MicroRNA and mRNA expression profile screening in multiple sclerosis patients to unravel novel pathogenic steps and identify potential biomarkers. Neurosci Lett 2012; 508: 4-8.
20. Lindberg RL, Hoffmann F, Mehling M, et al. Altered expression of miR-17-5p in CD4+ lymphocytes of relapsing-remitting multiple sclerosis patients. Eur J Immunol 2010; 40: 888-898.
21. Sievers C, Meira M, Hoffmann F, et al. Altered microRNA expression in B lymphocytes in multiple sclerosis: towards a better understanding of treatment effects. Clin Immunol 2012; 144: 70-79.
22. De Santis G, Ferracin M, Biondani A, et al. Altered miRNA expression in T regulatory cells in course of multiple sclerosis. J Neuroimmunol 2010; 226: 165-171.
23. Otaegui D, Baranzini SE, Armananzas R, et al. Differential micro RNA expression in PBMC from multiple sclerosis patients. PLoS One 2009; 4: e6309.
24. Lambert C, Desbarats J, Arbour N, et al. Dendritic cell differentiation signals induce anti-inflammatory properties in human adult microglia. J Immunol 2008; 181: 8288-8297.
25. D'Souza S, Alinauskas K, McCrea E, et al. Differential susceptibility of human CNS-derived cell populations to TNF-dependent and independent immune-mediated injury. J Neurosci 1995; 15: 7293-7300.
26. Li J, Smyth P, Cahill S, et al. Improved RNA quality and TaqMan Pre-amplification method (PreAmp) to enhance expression analysis from formalin fixed paraffin embedded (FFPE) materials. BMC Biotechnol 2008; 8: 10.
27. Livak KJ, Schmittgen TD,. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25: 402-408.
28. Fenoglio C, Cantoni C, De Riz M, et al. Expression and genetic analysis of miRNAs involved in CD4+ cell activation in patients with multiple sclerosis. Neurosci Lett 2011; 504: 9-12.
29. Lorenzi JC, Brum DG, Zanette DL, et al. miR-15a and 16-1 are downregulated in CD4+ T cells of multiple sclerosis relapsing patients. Int J Neurosci 2012; 122: 466-471.
30. Graff JW, Dickson AM, Clay G, et al. Identifying functional microRNAs in macrophages with polarized phenotypes. J Biol Chem 2012; 287: 21816-21825.
31. Cardoso AL, Guedes JR, Pereira de Almeida L, Pedroso de Lima MC,. miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production. Immunology 2012; 135: 73-88.
32. Leng RX, Pan HF, Qin WZ, et al. Role of microRNA-155 in autoimmunity. Cytokine Growth Factor Rev 2011; 22: 141-147.
33. Tarassishin L, Loudig O, Bauman A, et al. Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155. Glia 2011; 59: 1911-1922.
34. Rodriguez A, Vigorito E, Clare S, et al. Requirement of bic/microRNA-155 for normal immune function. Science 2007; 316: 608-611.
35. Thai TH, Calado DP, Casola S, et al. Regulation of the germinal center response by microRNA-155. Science 2007; 316: 604-608.
36. Bluml S, Bonelli M, Niederreiter B, et al. Essential role of microRNA-155 in the pathogenesis of autoimmune arthritis in mice. Arthritis Rheum 2011; 63: 1281-1288.
37. Murugaiyan G, Beynon V, Mittal A, et al. Silencing microRNA-155 ameliorates experimental autoimmune encephalomyelitis. J Immunol 2011; 187: 2213-2221.
38. Louafi F, Martinez-Nunez RT, Sanchez-Elsner T,. MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-{beta}. J Biol Chem 2010; 285: 41328-41336.
39. Filion LG, Matusevicius D, Graziani-Bowering GM, et al. Monocyte-derived IL12, CD86 (B7-2) and CD40L expression in relapsing and progressive multiple sclerosis. Clin Immunol 2003; 106: 127-138.
40. Williams K, Ulvestad E, Antel JP,. B7/BB-1 antigen expression on adult human microglia studied in vitro and in situ. Eur J Immunol 1994; 24: 3031-3037.
41. Kouwenhoven M, Teleshova N, Ozenci V, et al. Monocytes in multiple sclerosis: phenotype and cytokine profile. J Neuroimmunol 2001; 112: 197-205.
42. Hou J, Wang P, Lin L, et al. MicroRNA-146a feedback inhibits RIG-I-dependent type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J Immunol 2009; 183: 2150-2158.
43. Waschbisch A, Atiya M, Linker RA, et al. Glatiramer acetate treatment normalizes deregulated microRNA expression in relapsing remitting multiple sclerosis. PLoS One 2011; 6: e24604.
44. Taganov KD, Boldin MP, Chang KJ, Baltimore D,. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A 2006; 103: 12481-12486.
45. van Boxel-Dezaire AH, Zula JA, Xu Y, et al. Major differences in the responses of primary human leukocyte subsets to IFN-beta. J Immunol 2010; 185: 5888-5899.
46. Cogswell JP, Ward J, Taylor IA, et al. Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis 2008; 14: 27-41.
47. Lusardi TA, Farr CD, Faulkner CL, et al. Ischemic preconditioning regulates expression of microRNAs and a predicted target, MeCP2, in mouse cortex. J Cereb Blood Flow Metab 2010; 30: 744-756.
48. Ponomarev ED, Veremeyko T, Barteneva N, et al. MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-alpha-PU.1 pathway. Nat Med 2011; 17: 64-70.