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Volumn 6, Issue 2, 2014, Pages 829-859

The multifaceted roles of STAT3 signaling in the progression of prostate cancer

Author keywords

Androgen receptor; Castrate resistance; CSC; Metastasis; Prostate cancer; STAT3

Indexed keywords

ANDROGEN RECEPTOR; STAT3 PROTEIN;

EID: 84898859312     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers6020829     Document Type: Review
Times cited : (118)

References (219)
  • 1
    • 84886496878 scopus 로고    scopus 로고
    • Role of STAT3 in cancer metastasis and translational advances
    • doi:10.1155/2013/421821
    • Kamran, M.Z.; Patil, P.; Gude, R.P. Role of STAT3 in cancer metastasis and translational advances. Biomed. Res. Int. 2013, 2013, doi:10.1155/2013/421821.
    • (2013) Biomed. Res. Int , vol.2013
    • Kamran, M.Z.1    Patil, P.2    Gude, R.P.3
  • 2
    • 0032168152 scopus 로고    scopus 로고
    • Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
    • Heinrich, P.C.; Behrmann, I.; Muller-Newen, G.; Schaper, F.; Graeve, L. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem. J. 1998, 334, 297-314.
    • (1998) Biochem. J , vol.334 , pp. 297-314
    • Heinrich, P.C.1    Behrmann, I.2    Muller-Newen, G.3    Schaper, F.4    Graeve, L.5
  • 3
    • 0037443661 scopus 로고    scopus 로고
    • Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3
    • Niemand, C.; Nimmesgern, A.; Haan, S.; Fischer, P.; Schaper, F.; Rossaint, R.; Heinrich, P.C.; Muller-Newen, G. Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3. J. Immunol. 2003, 170, 3263-3272.
    • (2003) J. Immunol , vol.170 , pp. 3263-3272
    • Niemand, C.1    Nimmesgern, A.2    Haan, S.3    Fischer, P.4    Schaper, F.5    Rossaint, R.6    Heinrich, P.C.7    Muller-Newen, G.8
  • 4
    • 0033968596 scopus 로고    scopus 로고
    • Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR
    • Yokogami, K.; Wakisaka, S.; Avruch, J.; Reeves, S.A. Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Curr. Biol. 2000, 10, 47-50.
    • (2000) Curr. Biol , vol.10 , pp. 47-50
    • Yokogami, K.1    Wakisaka, S.2    Avruch, J.3    Reeves, S.A.4
  • 5
    • 79953208248 scopus 로고    scopus 로고
    • STAT3 signaling: Anticancer strategies and challenges
    • Johnston, P.A.; Grandis, J.R. STAT3 signaling: Anticancer strategies and challenges. Mol. Interv. 2011, 11, 18-26.
    • (2011) Mol. Interv , vol.11 , pp. 18-26
    • Johnston, P.A.1    Grandis, J.R.2
  • 6
    • 7944233465 scopus 로고    scopus 로고
    • Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis
    • Silva, C.M. Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis. Oncogene 2004, 23, 8017-8023.
    • (2004) Oncogene , vol.23 , pp. 8017-8023
    • Silva, C.M.1
  • 7
    • 0035952638 scopus 로고    scopus 로고
    • G protein coupled receptor signaling through the Src and STAT3 pathway: Role in proliferation and transformation
    • Ram, P.T.; Iyengar, R. G protein coupled receptor signaling through the Src and STAT3 pathway: Role in proliferation and transformation. Oncogene 2001, 20, 1601-1606.
    • (2001) Oncogene , vol.20 , pp. 1601-1606
    • Ram, P.T.1    Iyengar, R.2
  • 8
    • 0032746702 scopus 로고    scopus 로고
    • Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein
    • Turkson, J.; Turkson, J.; Bowman, T.; Adnane, J.; Zhang, Y.; Djeu, J.Y.; Sekharam, M.; Frank, D.A.; Holzman, L.B.; Wu, J. et al. Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein. Mol. Cell. Biol. 1999, 19, 7519-7528.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 7519-7528
    • Turkson, J.1    Turkson, J.2    Bowman, T.3    Adnane, J.4    Zhang, Y.5    Djeu, J.Y.6    Sekharam, M.7    Frank, D.A.8    Holzman, L.B.9    Wu, J.10
  • 9
    • 0030772458 scopus 로고    scopus 로고
    • STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation
    • Chung, J.; Uchida, E.; Grammer, T.C.; Blenis, J. STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Mol. Cell. Biol. 1997, 17, 6508-6516.
    • (1997) Mol. Cell. Biol , vol.17 , pp. 6508-6516
    • Chung, J.1    Uchida, E.2    Grammer, T.C.3    Blenis, J.4
  • 10
    • 0006603039 scopus 로고    scopus 로고
    • Serine phosphorylation and negative regulation of STAT3 by JNK
    • Lim, C.P.; Cao, X. Serine phosphorylation and negative regulation of STAT3 by JNK. J. Biol. Chem. 1999, 274, 31055-31061.
    • (1999) J. Biol. Chem , vol.274 , pp. 31055-31061
    • Lim, C.P.1    Cao, X.2
  • 11
    • 0033588229 scopus 로고    scopus 로고
    • Protein kinase C delta associates with and phosphorylates STAT3 in an interleukin-6-dependent manner
    • Jain, N.; Zhang, T.; Kee, W.H.; Li, W.; Cao, X. Protein kinase C delta associates with and phosphorylates STAT3 in an interleukin-6-dependent manner. J. Biol. Chem. 1999, 274, 24392-24400.
    • (1999) J. Biol. Chem , vol.274 , pp. 24392-24400
    • Jain, N.1    Zhang, T.2    Kee, W.H.3    Li, W.4    Cao, X.5
  • 12
    • 33646365075 scopus 로고    scopus 로고
    • Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements
    • Ma, J.; Cao, X. Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements. Cell. Signal. 2006, 18, 1117-1126.
    • (2006) Cell. Signal , vol.18 , pp. 1117-1126
    • Ma, J.1    Cao, X.2
  • 13
    • 84868693885 scopus 로고    scopus 로고
    • Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma
    • Subramaniam, A.; Shanmugam, M.K.; Perumal, E.; Li, F.; Nachiyappan, A.; Dai, X.; Swamy, S.N.; Ahn, K.S.; Kumar, A.P.; Tan, B.K. et al. Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma. Biochim. Biophys. Acta 2013, 1835, 46-60.
    • (2013) Biochim. Biophys. Acta , vol.1835 , pp. 46-60
    • Subramaniam, A.1    Shanmugam, M.K.2    Perumal, E.3    Li, F.4    Nachiyappan, A.5    Dai, X.6    Swamy, S.N.7    Ahn, K.S.8    Kumar, A.P.9    Tan, B.K.10
  • 14
    • 18844444774 scopus 로고    scopus 로고
    • HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
    • Gray, M.J.; Zhang, J.; Ellis, L.M.; Semenza, G.L.; Evans, D.B.; Watowich, S.S.; Gallick, G.E. HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene 2005, 24, 3110-3120.
    • (2005) Oncogene , vol.24 , pp. 3110-3120
    • Gray, M.J.1    Zhang, J.2    Ellis, L.M.3    Semenza, G.L.4    Evans, D.B.5    Watowich, S.S.6    Gallick, G.E.7
  • 15
    • 0037040924 scopus 로고    scopus 로고
    • Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a
    • Giraud, S.; Bienvenu, F.; Avril, S.; Gascan, H.; Heery, D.M.; Coqueret, O. Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a. J. Biol. Chem. 2002, 277, 8004-8011.
    • (2002) J. Biol. Chem , vol.277 , pp. 8004-8011
    • Giraud, S.1    Bienvenu, F.2    Avril, S.3    Gascan, H.4    Heery, D.M.5    Coqueret, O.6
  • 16
    • 79955623599 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 (STAT3): A promising target for anticancer therapy
    • Masciocchi, D.; Gelain, A.; Villa, S.; Meneghetti, F.; Barlocco, D. Signal transducer and activator of transcription 3 (STAT3): A promising target for anticancer therapy. Future Med. Chem. 2011, 3, 567-597.
    • (2011) Future Med. Chem , vol.3 , pp. 567-597
    • Masciocchi, D.1    Gelain, A.2    Villa, S.3    Meneghetti, F.4    Barlocco, D.5
  • 18
    • 41849116690 scopus 로고    scopus 로고
    • Roles of unphosphorylated STATs in signaling
    • Yang, J.; Stark, G.R. Roles of unphosphorylated STATs in signaling. Cell. Res. 2008, 18, 443-451.
    • (2008) Cell. Res , vol.18 , pp. 443-451
    • Yang, J.1    Stark, G.R.2
  • 19
    • 0036797750 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB
    • Yu, Z.; Zhang, W.; Kone, B.C. Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB. Biochem. J. 2002, 367, 97-105.
    • (2002) Biochem. J , vol.367 , pp. 97-105
    • Yu, Z.1    Zhang, W.2    Kone, B.C.3
  • 20
    • 84879459053 scopus 로고    scopus 로고
    • Molecular pathogenesis and progression of prostate cancer
    • Schrecengost, R.; Knudsen, K.E. Molecular pathogenesis and progression of prostate cancer. Semin. Oncol. 2013, 40, 244-258.
    • (2013) Semin. Oncol , vol.40 , pp. 244-258
    • Schrecengost, R.1    Knudsen, K.E.2
  • 22
    • 0032883932 scopus 로고    scopus 로고
    • Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system
    • Culig, Z.; Hoffmann, J.; Erdel, M.; Eder, I.E.; Hobisch, A.; Hittmair, A.; Bartsch, G.; Utermann, G.; Schneider, M.R.; Parczyk, K. et al. Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system. Br. J. Cancer 1999, 81, 242-251.
    • (1999) Br. J. Cancer , vol.81 , pp. 242-251
    • Culig, Z.1    Hoffmann, J.2    Erdel, M.3    Eder, I.E.4    Hobisch, A.5    Hittmair, A.6    Bartsch, G.7    Utermann, G.8    Schneider, M.R.9    Parczyk, K.10
  • 23
    • 84891052481 scopus 로고    scopus 로고
    • Genomic rearrangements of in prostate cancer
    • Phin, S.; Moore, M.W.; Cotter, P.D. Genomic rearrangements of in prostate cancer. Front. Oncol. 2013, 3, e240.
    • (2013) Front. Oncol , vol.3
    • Phin, S.1    Moore, M.W.2    Cotter, P.D.3
  • 25
    • 79952393630 scopus 로고    scopus 로고
    • Cooperation between STAT3 and AKT signaling leads to prostate tumor development in transgenic mice
    • Blando, J.M.; Carbajal, S.; Abel, E.; Beltran, L.; Conti, C.; Fischer, S.; DiGiovanni, J. Cooperation between STAT3 and AKT signaling leads to prostate tumor development in transgenic mice. Neoplasia 2011, 13, 254-265.
    • (2011) Neoplasia , vol.13 , pp. 254-265
    • Blando, J.M.1    Carbajal, S.2    Abel, E.3    Beltran, L.4    Conti, C.5    Fischer, S.6    Digiovanni, J.7
  • 26
    • 84886389273 scopus 로고    scopus 로고
    • Interleukin-6 and oncostatin-M synergize with the PI3K/AKT pathway to promote aggressive prostate malignancy in mouse and human tissues
    • Smith, D.A.; Kiba, A.; Zong, Y.; Witte, O.N. Interleukin-6 and oncostatin-M synergize with the PI3K/AKT pathway to promote aggressive prostate malignancy in mouse and human tissues. Mol. Cancer Res. 2013, 11, 1159-1165.
    • (2013) Mol. Cancer Res , vol.11 , pp. 1159-1165
    • Smith, D.A.1    Kiba, A.2    Zong, Y.3    Witte, O.N.4
  • 27
    • 80052461278 scopus 로고    scopus 로고
    • Prostate epithelial Pten/TP53 loss leads to transformation of multipotential progenitors and epithelial to mesenchymal transition
    • Martin, P.; Liu, Y.N.; Pierce, R.; Abou-Kheir, W.; Casey, O.; Seng, V.; Camacho, D.; Simpson, R.M.; Kelly, K. Prostate epithelial Pten/TP53 loss leads to transformation of multipotential progenitors and epithelial to mesenchymal transition. Am. J. Pathol. 2011, 179, 422-435.
    • (2011) Am. J. Pathol , vol.179 , pp. 422-435
    • Martin, P.1    Liu, Y.N.2    Pierce, R.3    Abou-Kheir, W.4    Casey, O.5    Seng, V.6    Camacho, D.7    Simpson, R.M.8    Kelly, K.9
  • 28
    • 84873530895 scopus 로고    scopus 로고
    • Increased PrLZ-mediated androgen receptor transactivation promotes prostate cancer growth at castration-resistant stage
    • Li, L.; Xie, H.; Liang, L.; Gao, Y.; Zhang, D.; Fang, L.; Lee, S.O.; Luo, J.; Chen, X.; Wang, X. et al. Increased PrLZ-mediated androgen receptor transactivation promotes prostate cancer growth at castration-resistant stage. Carcinogenesis 2013, 34, 257-267.
    • (2013) Carcinogenesis , vol.34 , pp. 257-267
    • Li, L.1    Xie, H.2    Liang, L.3    Gao, Y.4    Zhang, D.5    Fang, L.6    Lee, S.O.7    Luo, J.8    Chen, X.9    Wang, X.10
  • 29
    • 79952763967 scopus 로고    scopus 로고
    • PrLZ protects prostate cancer cells from apoptosis induced by androgen deprivation via the activation of Stat3/Bcl-2 pathway
    • Zhang, D.; He, D.; Xue, Y.; Wang, R.; Wu, K.; Xie, H.; Zeng, J.; Wang, X.; Zhau, H.E.; Chung, L.W. et al. PrLZ protects prostate cancer cells from apoptosis induced by androgen deprivation via the activation of Stat3/Bcl-2 pathway. Cancer Res. 2011, 71, 2193-2202.
    • (2011) Cancer Res , vol.71 , pp. 2193-2202
    • Zhang, D.1    He, D.2    Xue, Y.3    Wang, R.4    Wu, K.5    Xie, H.6    Zeng, J.7    Wang, X.8    Zhau, H.E.9    Chung, L.W.10
  • 30
    • 84884212418 scopus 로고    scopus 로고
    • Expression of Id proteins is regulated by the Bcl-3 proto-oncogene in prostate cancer
    • Ahlqvist, K.; Saamarthy, K.; Syed Khaja, A.S.; Bjartell, A.; Massoumi, R. Expression of Id proteins is regulated by the Bcl-3 proto-oncogene in prostate cancer. Oncogene 2013, 32, 1601-1608.
    • (2013) Oncogene , vol.32 , pp. 1601-1608
    • Ahlqvist, K.1    Saamarthy, K.2    Syed Khaja, A.S.3    Bjartell, A.4    Massoumi, R.5
  • 31
    • 55349110263 scopus 로고    scopus 로고
    • Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice
    • Lee, C.; Dhillon, J.; Wang, M.Y.; Gao, Y.; Hu, K.; Park, E.; Astanehe, A.; Hung, M.C.; Eirew, P.; Eaves, C.J. et al. Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice. Cancer Res. 2008, 68, 8661-8666.
    • (2008) Cancer Res , vol.68 , pp. 8661-8666
    • Lee, C.1    Dhillon, J.2    Wang, M.Y.3    Gao, Y.4    Hu, K.5    Park, E.6    Astanehe, A.7    Hung, M.C.8    Eirew, P.9    Eaves, C.J.10
  • 35
    • 0032830265 scopus 로고    scopus 로고
    • Elevated levels of circulating interleukin-6 and transforming growth factor-beta1 in patients with metastatic prostatic carcinoma
    • Adler, H.L.; McCurdy, M.A.; Kattan, M.W.; Timme, T.L.; Scardino, P.T.; Thompson, T.C. Elevated levels of circulating interleukin-6 and transforming growth factor-beta1 in patients with metastatic prostatic carcinoma. J. Urol. 1999, 161, 182-187.
    • (1999) J. Urol , vol.161 , pp. 182-187
    • Adler, H.L.1    McCurdy, M.A.2    Kattan, M.W.3    Timme, T.L.4    Scardino, P.T.5    Thompson, T.C.6
  • 37
    • 0036510548 scopus 로고    scopus 로고
    • Activation of the androgen receptor N-terminal domai by interleukin-6 via MAPK and STAT3 signal transduction pathways
    • Ueda, T.; Bruchovsky, N.; Sadar, M.D. Activation of the androgen receptor N-terminal domai by interleukin-6 via MAPK and STAT3 signal transduction pathways. J. Biol. Chem. 2002, 27 7076-7085.
    • (2002) J. Biol. Chem , vol.27 , pp. 7076-7085
    • Ueda, T.1    Bruchovsky, N.2    Sadar, M.D.3
  • 39
    • 0034651796 scopus 로고    scopus 로고
    • STAT3 mediates IL-6-induced neuroendocrine differentiation i prostate cancer cells
    • Spiotto, M.T.; Chung, T.D. STAT3 mediates IL-6-induced neuroendocrine differentiation i prostate cancer cells. Prostate 2000, 42, 186-195.
    • (2000) Prostate , vol.42 , pp. 186-195
    • Spiotto, M.T.1    Chung, T.D.2
  • 40
    • 21344441226 scopus 로고    scopus 로고
    • P300 Regulate androgen receptor-independent expression of prostate-specific antigen in prostate cancer cel treated chronically with interleukin-6
    • Debes, J.D.; Comuzzi, B.; Schmidt, L.J.; Dehm, S.M.; Culig, Z.; Tindall, D.J. P300 Regulate androgen receptor-independent expression of prostate-specific antigen in prostate cancer cel treated chronically with interleukin-6. Cancer Res. 2005, 65, 5965-5973.
    • (2005) Cancer Res , vol.65 , pp. 5965-5973
    • Debes, J.D.1    Comuzzi, B.2    Schmidt, L.J.3    Dehm, S.M.4    Culig, Z.5    Tindall, D.J.6
  • 41
    • 0034817053 scopus 로고    scopus 로고
    • Culig, Prostate cancer cells (LNCaP) generated after long-term interleukin 6 (IL-6) treatment expre IL-6 and acquire an IL-6 partially resistant phenotype
    • Hobisch, A.; Ramoner, R.; Fuchs, D.; Godoy-Tundidor, S.; Bartsch, G.; Klocker, H.; Culig, Prostate cancer cells (LNCaP) generated after long-term interleukin 6 (IL-6) treatment expre IL-6 and acquire an IL-6 partially resistant phenotype. Clin. Cancer Res. 2001, 7, 2941-2948.
    • (2001) Clin. Cancer Res , vol.7 , pp. 2941-2948
    • Hobisch, A.1    Ramoner, R.2    Fuchs, D.3    Godoy-Tundidor, S.4    Bartsch, G.5    Klocker, H.6
  • 42
    • 0034901655 scopus 로고    scopus 로고
    • Interleukin-6 induces androgen responsivene in prostate cancer cells through up-regulation of androgen receptor expression
    • Lin, D.L.; Whitney, M.C.; Yao, Z.; Keller, E.T. Interleukin-6 induces androgen responsivene in prostate cancer cells through up-regulation of androgen receptor expression. Clin. Cancer Re 2001, 7, 1773-1781.
    • (2001) Clin. Cancer Re , vol.7 , pp. 1773-1781
    • Lin, D.L.1    Whitney, M.C.2    Yao, Z.3    Keller, E.T.4
  • 43
    • 84864283846 scopus 로고    scopus 로고
    • LNCaP prostate cancer cells wit autocrine interleukin-6 expression are resistant to IL-6-induced neuroendocrine differentiatio due to increased expression of suppressors of cytokine signaling
    • Ge, D.; Gao, A.C.; Zhang, Q.; Liu, S.; Xue, Y.; You, Z. LNCaP prostate cancer cells wit autocrine interleukin-6 expression are resistant to IL-6-induced neuroendocrine differentiatio due to increased expression of suppressors of cytokine signaling. Prostate 2012, 72, 1306-1316
    • (2012) Prostate , vol.72 , pp. 1306-1316
    • Ge, D.1    Gao, A.C.2    Zhang, Q.3    Liu, S.4    Xue, Y.5    You, Z.6
  • 44
    • 77549083560 scopus 로고    scopus 로고
    • Dangerous liaisons: STAT3 and NF-κB collaboration and crosstal in cancer
    • Grivennikov, S.I.; Karin, M. Dangerous liaisons: STAT3 and NF-κB collaboration and crosstal in cancer. Cytokine Growth Factor Rev. 2010, 21, 11-19.
    • (2010) Cytokine Growth Factor Rev , vol.21 , pp. 11-19
    • Grivennikov, S.I.1    Karin, M.2
  • 46
    • 84891160894 scopus 로고    scopus 로고
    • Inhibition of constitutively activ Stat3 reverses enzalutamide resistance in LNCaP derivative prostate cancer cells
    • Liu, C.; Zhu, Y.; Lou, W.; Cui, Y.; Evans, C.P.; Gao, A.C. Inhibition of constitutively activ Stat3 reverses enzalutamide resistance in LNCaP derivative prostate cancer cells. Prostate 201 74, 201-209.
    • Prostate 201 , vol.74 , pp. 201-209
    • Liu, C.1    Zhu, Y.2    Lou, W.3    Cui, Y.4    Evans, C.P.5    Gao, A.C.6
  • 47
    • 84882274167 scopus 로고    scopus 로고
    • NF-kappaB2/p5 induces resistance to enzalutamide in prostate cancer: Role of androgen receptor and its variant
    • Nadiminty, N.; Tummala, R.; Liu, C.; Yang, J.; Lou, W.; Evans, C.P.; Gao, A.C. NF-kappaB2/p5 induces resistance to enzalutamide in prostate cancer: Role of androgen receptor and its variant Mol. Cancer Ther. 2013, 12, 1629-1637.
    • (2013) Mol. Cancer Ther , vol.12 , pp. 1629-1637
    • Nadiminty, N.1    Tummala, R.2    Liu, C.3    Yang, J.4    Lou, W.5    Evans, C.P.6    Gao, A.C.7
  • 48
    • 84861611628 scopus 로고    scopus 로고
    • NF-κB signaling in prosta cancer: A promising therapeutic target? World
    • Jain, G.; Cronauer, M.V.; Schrader, M.; Moller, P.; Marienfeld, R.B. NF-κB signaling in prosta cancer: A promising therapeutic target? World J. Urol. 2012, 30, 303-310.
    • (2012) J. Urol , vol.30 , pp. 303-310
    • Jain, G.1    Cronauer, M.V.2    Schrader, M.3    Moller, P.4    Marienfeld, R.B.5
  • 49
    • 84866324123 scopus 로고    scopus 로고
    • Cancer stem cells and epithelial-mesenchymal transition: Concep and molecular links
    • doi:10.1016/j.semcancer
    • Scheel, C.; Weinberg, R.A. Cancer stem cells and epithelial-mesenchymal transition: Concep and molecular links. Semin. Cancer Biol. 2012, doi:10.1016/j.semcancer.
    • (2012) Semin. Cancer Biol
    • Scheel, C.1    Weinberg, R.A.2
  • 51
    • 84855484465 scopus 로고    scopus 로고
    • Molecular classification of prostate cancer using curated expression signatures
    • Markert, E.K.; Mizuno, H.; Vazquez, A.; Levine, A.J. Molecular classification of prostate cancer using curated expression signatures. Proc. Natl. Acad. Sci. USA 2011, 108, 21276-21281.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 21276-21281
    • Markert, E.K.1    Mizuno, H.2    Vazquez, A.3    Levine, A.J.4
  • 52
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer
    • Singh, A.; Settleman, J. EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer. Oncogene 2010, 29, 4741-4751.
    • (2010) Oncogene , vol.29 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 53
    • 84874299107 scopus 로고    scopus 로고
    • New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells
    • Lee, S.O.; Ma, Z.; Yeh, C.R.; Luo, J.; Lin, T.H.; Lai, K.P.; Yamashita, S.; Liang, L.; Tian, J.; Li, L. et al. New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells. J. Mol. Cell. Biol. 2013, 5, 14-26.
    • (2013) J. Mol. Cell. Biol , vol.5 , pp. 14-26
    • Lee, S.O.1    Ma, Z.2    Yeh, C.R.3    Luo, J.4    Lin, T.H.5    Lai, K.P.6    Yamashita, S.7    Liang, L.8    Tian, J.9    Li, L.10
  • 54
    • 84865839326 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: Insights from development
    • Lim, J.; Thiery, J.P. Epithelial-mesenchymal transitions: Insights from development. Development 2012, 139, 3471-3486.
    • (2012) Development , vol.139 , pp. 3471-3486
    • Lim, J.1    Thiery, J.P.2
  • 55
    • 80051703400 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition in prostate cancer: Paradigm or puzzle
    • Nauseef, J.T.; Henry, M.D. Epithelial-to-mesenchymal transition in prostate cancer: Paradigm or puzzle? Nat. Rev. Urol. 2011, 8, 428-439.
    • (2011) Nat. Rev. Urol , vol.8 , pp. 428-439
    • Nauseef, J.T.1    Henry, M.D.2
  • 56
    • 77953576511 scopus 로고    scopus 로고
    • N-cadherin increases after androgen deprivation and is associated with metastasis in prostate cancer
    • Jennbacken, K.; Tesan, T.; Wang, W.; Gustavsson, H.; Damber, J.E.; Welen, K. N-cadherin increases after androgen deprivation and is associated with metastasis in prostate cancer. Endocr. Relat. Cancer 2010, 17, 469-479.
    • (2010) Endocr. Relat. Cancer , vol.17 , pp. 469-479
    • Jennbacken, K.1    Tesan, T.2    Wang, W.3    Gustavsson, H.4    Damber, J.E.5    Welen, K.6
  • 57
    • 84898923581 scopus 로고    scopus 로고
    • JAK-STAT3 and somatic cell reprogramming
    • Tang, Y.; Tian, X.C. JAK-STAT3 and somatic cell reprogramming. JAKSTAT 2013, 2, e24935.
    • (2013) JAKSTAT , vol.2
    • Tang, Y.1    Tian, X.C.2
  • 58
    • 84869204649 scopus 로고    scopus 로고
    • Targeting the unique methylation pattern of androgen receptor (AR) promoter in prostate stem/progenitor cells with 5-aza-2'-deoxycytidine (5-AZA) leads to suppressed prostate tumorigenesis
    • Tian, J.; Lee, S.O.; Liang, L.; Luo, J.; Huang, C.K.; Li, L.; Niu, Y.; Chang, C. Targeting the unique methylation pattern of androgen receptor (AR) promoter in prostate stem/progenitor cells with 5-aza-2'-deoxycytidine (5-AZA) leads to suppressed prostate tumorigenesis. J. Biol. Chem. 2012, 287, 39954-39966.
    • (2012) J. Biol. Chem , vol.287 , pp. 39954-39966
    • Tian, J.1    Lee, S.O.2    Liang, L.3    Luo, J.4    Huang, C.K.5    Li, L.6    Niu, Y.7    Chang, C.8
  • 59
    • 84860642507 scopus 로고    scopus 로고
    • The PSA(-/lo) prostate cancer cell population harbors self-renewing long-term tumor-propagating cells that resist castration
    • Qin, J.; Liu, X.; Laffin, B.; Chen, X.; Choy, G.; Jeter, C.R.; Calhoun-Davis, T.; Li, H.; Palapattu, G.S.; Pang, S. et al. The PSA(-/lo) prostate cancer cell population harbors self-renewing long-term tumor-propagating cells that resist castration. Cell Stem Cell 2012, 10, 556-569.
    • (2012) Cell Stem Cell , vol.10 , pp. 556-569
    • Qin, J.1    Liu, X.2    Laffin, B.3    Chen, X.4    Choy, G.5    Jeter, C.R.6    Calhoun-Davis, T.7    Li, H.8    Palapattu, G.S.9    Pang, S.10
  • 60
    • 84894284619 scopus 로고    scopus 로고
    • Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling
    • doi:10.1158/0008-5472.CAN-13-0594
    • Schroeder, A.; Herrmann, A.; Cherryholmes, G.; Kowolik, C.; Buettner, R.; Pal, S.; Yu, H.; Mueller-Newen, G.; Jove, R. Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling. Cancer Res. 2013, doi:10.1158/0008-5472.CAN-13-0594.
    • (2013) Cancer Res
    • Schroeder, A.1    Herrmann, A.2    Cherryholmes, G.3    Kowolik, C.4    Buettner, R.5    Pal, S.6    Yu, H.7    Mueller-Newen, G.8    Jove, R.9
  • 61
    • 39449098191 scopus 로고    scopus 로고
    • Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated STAT3
    • Hellsten, R.; Johansson, M.; Dahlman, A.; Dizeyi, N.; Sterner, O.; Bjartell, A. Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated STAT3. Prostate 2008, 68, 269-280.
    • (2008) Prostate , vol.68 , pp. 269-280
    • Hellsten, R.1    Johansson, M.2    Dahlman, A.3    Dizeyi, N.4    Sterner, O.5    Bjartell, A.6
  • 63
    • 65549140597 scopus 로고    scopus 로고
    • Effects of the sesquiterpene lactone parthenolide on prostate tumor-initiating cells: An integrated molecular profiling approach
    • Kawasaki, B.T.; Hurt, E.M.; Kalathur, M.; Duhagon, M.A.; Milner, J.A.; Kim, Y.S.; Farrar, W.L. Effects of the sesquiterpene lactone parthenolide on prostate tumor-initiating cells: An integrated molecular profiling approach. Prostate 2009, 69, 827-837.
    • (2009) Prostate , vol.69 , pp. 827-837
    • Kawasaki, B.T.1    Hurt, E.M.2    Kalathur, M.3    Duhagon, M.A.4    Milner, J.A.5    Kim, Y.S.6    Farrar, W.L.7
  • 64
    • 84864465226 scopus 로고    scopus 로고
    • Clinical implications of cancer stem cell biology in hepatocellular carcinoma
    • Ji, J.; Wang, X.W. Clinical implications of cancer stem cell biology in hepatocellular carcinoma. Semin. Oncol. 2012, 39, 461-472.
    • (2012) Semin. Oncol , vol.39 , pp. 461-472
    • Ji, J.1    Wang, X.W.2
  • 65
    • 84873537569 scopus 로고    scopus 로고
    • Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells
    • Kim, S.Y.; Kang, J.W.; Song, X.; Kim, B.K.; Yoo, Y.D.; Kwon, Y.T.; Lee, Y.J. Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells. Cell Signal. 2013, 25, 961-969.
    • (2013) Cell Signal , vol.25 , pp. 961-969
    • Kim, S.Y.1    Kang, J.W.2    Song, X.3    Kim, B.K.4    Yoo, Y.D.5    Kwon, Y.T.6    Lee, Y.J.7
  • 66
    • 84895756231 scopus 로고    scopus 로고
    • RhoC regulates cancer stem cells in head and neck squamous cell carcinoma by overexpressing IL-6 and phosphorylation of STAT3
    • Islam, M.; Sharma, S.; Teknos, T.N. RhoC regulates cancer stem cells in head and neck squamous cell carcinoma by overexpressing IL-6 and phosphorylation of STAT3. PLoS One 2014, 9, e88527.
    • (2014) PLoS One , vol.9
    • Islam, M.1    Sharma, S.2    Teknos, T.N.3
  • 69
    • 84890295938 scopus 로고    scopus 로고
    • Generation of prostate tumor-initiating cells is associated with elevation of reactive oxygen species and IL-6/STAT3 signaling
    • Qu, Y.; Oyan, A.M.; Liu, R.; Hua, Y.; Zhang, J.; Hovland, R.; Popa, M.; Liu, X.; Brokstad, K.A.; Simon, R. et al. Generation of prostate tumor-initiating cells is associated with elevation of reactive oxygen species and IL-6/STAT3 signaling. Cancer Res. 2013, 73, 7090-7100.
    • (2013) Cancer Res , vol.73 , pp. 7090-7100
    • Qu, Y.1    Oyan, A.M.2    Liu, R.3    Hua, Y.4    Zhang, J.5    Hovland, R.6    Popa, M.7    Liu, X.8    Brokstad, K.A.9    Simon, R.10
  • 71
    • 77957902732 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells
    • Kong, D.; Banerjee, S.; Ahmad, A.; Li, Y.; Wang, Z.; Sethi, S.; Sarkar, F.H. Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells. PLoS One 2010, 5, e12445.
    • (2010) PLoS One , vol.5
    • Kong, D.1    Banerjee, S.2    Ahmad, A.3    Li, Y.4    Wang, Z.5    Sethi, S.6    Sarkar, F.H.7
  • 73
    • 84883366629 scopus 로고    scopus 로고
    • Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2/CCR2-induced STAT3 activation
    • Izumi, K.; Fang, L.Y.; Mizokami, A.; Namiki, M.; Li, L.; Lin, W.J.; Chang, C. Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2/CCR2-induced STAT3 activation. EMBO Mol. Med. 2013, 5, 1383-1401.
    • (2013) EMBO Mol. Med , vol.5 , pp. 1383-1401
    • Izumi, K.1    Fang, L.Y.2    Mizokami, A.3    Namiki, M.4    Li, L.5    Lin, W.J.6    Chang, C.7
  • 74
    • 84894231936 scopus 로고    scopus 로고
    • A ROS/STAT3/HIF-1alpha signaling cascade mediates EGF-induced TWIST1 expression and prostate cancer cell invasion
    • doi:10.1002/pros.22776
    • Cho, K.H.; Choi, M.J.; Jeong, K.J.; Kim, J.J.; Hwang, M.H.; Shin, S.C.; Park, C.G.; Lee, H.Y. A ROS/STAT3/HIF-1alpha signaling cascade mediates EGF-induced TWIST1 expression and prostate cancer cell invasion. Prostate 2014, doi:10.1002/pros.22776.
    • (2014) Prostate
    • Cho, K.H.1    Choi, M.J.2    Jeong, K.J.3    Kim, J.J.4    Hwang, M.H.5    Shin, S.C.6    Park, C.G.7    Lee, H.Y.8
  • 75
    • 84878960353 scopus 로고    scopus 로고
    • STAT3 mediates TGF-β1-induced TWIST1 expression and prostate cancer invasion
    • Cho, K.H.; Jeong, K.J.; Shin, S.C.; Kang, J.; Park, C.G.; Lee, H.Y. STAT3 mediates TGF-β1-induced TWIST1 expression and prostate cancer invasion. Cancer Lett. 2013, 336, 167-173.
    • (2013) Cancer Lett , vol.336 , pp. 167-173
    • Cho, K.H.1    Jeong, K.J.2    Shin, S.C.3    Kang, J.4    Park, C.G.5    Lee, H.Y.6
  • 76
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D.; Weinberg, R.A. The hallmarks of cancer. Cell 2000, 100, 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 77
    • 0033119833 scopus 로고    scopus 로고
    • Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function
    • Grunstein, J.; Roberts, W.G.; Mathieu-Costello, O.; Hanahan, D.; Johnson, R.S. Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function. Cancer Res. 1999, 59, 1592-1598.
    • (1999) Cancer Res , vol.59 , pp. 1592-1598
    • Grunstein, J.1    Roberts, W.G.2    Mathieu-Costello, O.3    Hanahan, D.4    Johnson, R.S.5
  • 78
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
    • Plate, K.H.; Breier, G.; Weich, H.A.; Risau, W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 1992, 359, 845-848.
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3    Risau, W.4
  • 79
    • 39549102220 scopus 로고    scopus 로고
    • STAT3: A critical transcription activator in angiogenesis
    • Chen, Z.; Han, Z.C. STAT3: A critical transcription activator in angiogenesis. Med. Res. Rev. 2008, 28, 185-200.
    • (2008) Med. Res. Rev , vol.28 , pp. 185-200
    • Chen, Z.1    Han, Z.C.2
  • 80
    • 24644457736 scopus 로고    scopus 로고
    • Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways
    • Xu, Q.; Briggs, J.; Park, S.; Niu, G.; Kortylewski, M.; Zhang, S.; Gritsko, T.; Turkson, J.; Kay, H.; Semenza, G.L. et al. Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways. Oncogene 2005, 24, 5552-5560.
    • (2005) Oncogene , vol.24 , pp. 5552-5560
    • Xu, Q.1    Briggs, J.2    Park, S.3    Niu, G.4    Kortylewski, M.5    Zhang, S.6    Gritsko, T.7    Turkson, J.8    Kay, H.9    Semenza, G.L.10
  • 81
    • 0037461934 scopus 로고    scopus 로고
    • Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis
    • Wei, D.; Le, X.; Zheng, L.; Wang, L.; Frey, J.A.; Gao, A.C.; Peng, Z.; Huang, S.; Xiong, H.Q.; Abbruzzese, J.L. et al. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 2003, 22, 319-329.
    • (2003) Oncogene , vol.22 , pp. 319-329
    • Wei, D.1    Le, X.2    Zheng, L.3    Wang, L.4    Frey, J.A.5    Gao, A.C.6    Peng, Z.7    Huang, S.8    Xiong, H.Q.9    Abbruzzese, J.L.10
  • 83
    • 84873041658 scopus 로고    scopus 로고
    • Androgen up-regulates vascular endothelial growth factor expression in prostate cancer cells via an Sp1 binding site
    • Eisermann, K.; Broderick, C.J.; Bazarov, A.; Moazam, M.M.; Fraizer, G.C. Androgen up-regulates vascular endothelial growth factor expression in prostate cancer cells via an Sp1 binding site. Mol. Cancer 2013, 12, e7.
    • (2013) Mol. Cancer , vol.12
    • Eisermann, K.1    Broderick, C.J.2    Bazarov, A.3    Moazam, M.M.4    Fraizer, G.C.5
  • 84
    • 79960890780 scopus 로고    scopus 로고
    • JAK2/STAT3 signaling pathway activation mediates tumor angiogenesis by upregulation of VEGF and bFGF in non-small-cell lung cancer
    • Zhao, M.; Gao, F.H.; Wang, J.Y.; Liu, F.; Yuan, H.H.; Zhang, W.Y.; Jiang, B. JAK2/STAT3 signaling pathway activation mediates tumor angiogenesis by upregulation of VEGF and bFGF in non-small-cell lung cancer. Lung Cancer 2011, 73, 366-374.
    • (2011) Lung Cancer , vol.73 , pp. 366-374
    • Zhao, M.1    Gao, F.H.2    Wang, J.Y.3    Liu, F.4    Yuan, H.H.5    Zhang, W.Y.6    Jiang, B.7
  • 86
    • 84878339255 scopus 로고    scopus 로고
    • Delivery of the co-expression plasmid pEndo-Si-STAT3 by attenuated Salmonella serovar typhimurium for prostate cancer treatment
    • Li, X.; Li, Y.; Wang, B.; Ji, K.; Liang, Z.; Guo, B.; Hu, J.; Yin, D.; Du, Y.; Kopecko, D.J. et al. Delivery of the co-expression plasmid pEndo-Si-STAT3 by attenuated Salmonella serovar typhimurium for prostate cancer treatment. J. Cancer Res. Clin. Oncol. 2013, 139, 971-980.
    • (2013) J. Cancer Res. Clin. Oncol , vol.139 , pp. 971-980
    • Li, X.1    Li, Y.2    Wang, B.3    Ji, K.4    Liang, Z.5    Guo, B.6    Hu, J.7    Yin, D.8    Du, Y.9    Kopecko, D.J.10
  • 87
    • 55549090712 scopus 로고    scopus 로고
    • Hepatitis C virus core protein augments androgen receptor-mediated signaling
    • Kanda, T.; Steele, R.; Ray, R.; Ray, R.B. Hepatitis C virus core protein augments androgen receptor-mediated signaling. J. Virol. 2008, 82, 11066-11072.
    • (2008) J. Virol , vol.82 , pp. 11066-11072
    • Kanda, T.1    Steele, R.2    Ray, R.3    Ray, R.B.4
  • 88
    • 84878142242 scopus 로고    scopus 로고
    • Plumbagin, a medicinal plant (Plumbago zeylanica)-derived 1,4-naphthoquinone, inhibits growth and metastasis of human prostate cancer PC-3M-luciferase cells in an orthotopic xenograft mouse model
    • Hafeez, B.B.; Zhong, W.; Fischer, J.W.; Mustafa, A.; Shi, X.; Meske, L.; Hong, H.; Cai, W.; Havighurst, T.; Kim, K. et al. Plumbagin, a medicinal plant (Plumbago zeylanica)-derived 1,4-naphthoquinone, inhibits growth and metastasis of human prostate cancer PC-3M-luciferase cells in an orthotopic xenograft mouse model. Mol. Oncol. 2013, 7, 428-439.
    • (2013) Mol. Oncol , vol.7 , pp. 428-439
    • Hafeez, B.B.1    Zhong, W.2    Fischer, J.W.3    Mustafa, A.4    Shi, X.5    Meske, L.6    Hong, H.7    Cai, W.8    Havighurst, T.9    Kim, K.10
  • 89
    • 84870326497 scopus 로고    scopus 로고
    • Plumbagin inhibits prostate cancer development in TRAMP mice via targeting PKCepsilon, Stat3 and neuroendocrine markers
    • Hafeez, B.B.; Zhong, W.; Mustafa, A.; Fischer, J.W.; Witkowsky, O.; Verma, A.K. Plumbagin inhibits prostate cancer development in TRAMP mice via targeting PKCepsilon, Stat3 and neuroendocrine markers. Carcinogenesis 2012, 33, 2586-2592.
    • (2012) Carcinogenesis , vol.33 , pp. 2586-2592
    • Hafeez, B.B.1    Zhong, W.2    Mustafa, A.3    Fischer, J.W.4    Witkowsky, O.5    Verma, A.K.6
  • 90
    • 55349147671 scopus 로고    scopus 로고
    • Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer
    • Aziz, M.H.; Dreckschmidt, N.E.; Verma, A.K. Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Cancer Res. 2008, 68, 9024-9032.
    • (2008) Cancer Res , vol.68 , pp. 9024-9032
    • Aziz, M.H.1    Dreckschmidt, N.E.2    Verma, A.K.3
  • 91
    • 79959606207 scopus 로고    scopus 로고
    • Suppression of STAT3 and HIF-1 alpha mediates anti-angiogenic activity of betulinic acid in hypoxic PC-3 prostate cancer cells
    • Shin, J.; Lee, H.J.; Jung, D.B.; Jung, J.H.; Lee, E.O.; Lee, S.G.; Shim, B.S.; Choi, S.H.; Ko, S.G.; Ahn, K.S. et al. Suppression of STAT3 and HIF-1 alpha mediates anti-angiogenic activity of betulinic acid in hypoxic PC-3 prostate cancer cells. PLoS One 2011, 6, e21492.
    • (2011) PLoS One , vol.6
    • Shin, J.1    Lee, H.J.2    Jung, D.B.3    Jung, J.H.4    Lee, E.O.5    Lee, S.G.6    Shim, B.S.7    Choi, S.H.8    Ko, S.G.9    Ahn, K.S.10
  • 92
    • 80052962987 scopus 로고    scopus 로고
    • Indirubin inhibits tumor growth by antitumor angiogenesis via blocking VEGFR2-mediated JAK/STAT3 signaling in endothelial cell
    • Zhang, X.; Song, Y.; Wu, Y.; Dong, Y.; Lai, L.; Zhang, J.; Lu, B.; Dai, F.; He, L.; Liu, M. et al. Indirubin inhibits tumor growth by antitumor angiogenesis via blocking VEGFR2-mediated JAK/STAT3 signaling in endothelial cell. Int. J. Cancer 2011, 129, 2502-2511.
    • (2011) Int. J. Cancer , vol.129 , pp. 2502-2511
    • Zhang, X.1    Song, Y.2    Wu, Y.3    Dong, Y.4    Lai, L.5    Zhang, J.6    Lu, B.7    Dai, F.8    He, L.9    Liu, M.10
  • 93
    • 80054057846 scopus 로고    scopus 로고
    • Combined treatment targeting HIF-1α and STAT3 is a potent strategy for prostate cancer therapy
    • Reddy, K.R.; Guan, Y.; Qin, G.; Zhou, Z.; Jing, N. Combined treatment targeting HIF-1α and STAT3 is a potent strategy for prostate cancer therapy. Prostate 2011, 71, 1796-1809.
    • (2011) Prostate , vol.71 , pp. 1796-1809
    • Reddy, K.R.1    Guan, Y.2    Qin, G.3    Zhou, Z.4    Jing, N.5
  • 94
    • 84864389212 scopus 로고    scopus 로고
    • A novel regulation of VEGF expression by HIF-1α and STAT3 in HDM2 transfected prostate cancer cells
    • Rathinavelu, A.; Narasimhan, M.; Muthumani, P. A novel regulation of VEGF expression by HIF-1α and STAT3 in HDM2 transfected prostate cancer cells. J. Cell. Mol. Med. 2012, 16, 1750-1757.
    • (2012) J. Cell. Mol. Med , vol.16 , pp. 1750-1757
    • Rathinavelu, A.1    Narasimhan, M.2    Muthumani, P.3
  • 95
    • 84869223265 scopus 로고    scopus 로고
    • The reactive stroma microenvironment and prostate cancer progression
    • Barron, D.A.; Rowley, D.R. The reactive stroma microenvironment and prostate cancer progression. Endocr. Relat. Cancer 2012, 19, R187-R204.
    • (2012) Endocr. Relat. Cancer , vol.19
    • Barron, D.A.1    Rowley, D.R.2
  • 96
    • 84886383331 scopus 로고    scopus 로고
    • Mesenchymal stem cells as a vector for the inflammatory prostate microenvironment
    • Brennen, W.N.; Denmeade, S.R.; Isaacs, J.T. Mesenchymal stem cells as a vector for the inflammatory prostate microenvironment. Endocr. Relat. Cancer 2013, 20, R269-R290.
    • (2013) Endocr. Relat. Cancer , vol.20
    • Brennen, W.N.1    Denmeade, S.R.2    Isaacs, J.T.3
  • 99
    • 84895926497 scopus 로고    scopus 로고
    • Extracellular Hsp90 mediates an NF-κB dependent inflammatory stromal program: Implications for the prostate tumor microenvironment
    • Bohonowych, J.; Hance, M.; Nolan, K.; Defee, M.; Parsons, C.; Isaacs, J. Extracellular Hsp90 mediates an NF-κB dependent inflammatory stromal program: Implications for the prostate tumor microenvironment. Prostate 2014, 74, 395-407.
    • (2014) Prostate , vol.74 , pp. 395-407
    • Bohonowych, J.1    Hance, M.2    Nolan, K.3    Defee, M.4    Parsons, C.5    Isaacs, J.6
  • 100
    • 84861882582 scopus 로고    scopus 로고
    • CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells
    • Tsuyada, A.; Chow, A.; Wu, J.; Somlo, G.; Chu, P.; Loera, S.; Luu, T.; Li, A.X.; Wu, X.; Ye, W. et al. CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res. 2012, 72, 2768-2779.
    • (2012) Cancer Res , vol.72 , pp. 2768-2779
    • Tsuyada, A.1    Chow, A.2    Wu, J.3    Somlo, G.4    Chu, P.5    Loera, S.6    Luu, T.7    Li, A.X.8    Wu, X.9    Ye, W.10
  • 101
    • 84898912407 scopus 로고    scopus 로고
    • A CCL2/ROS autoregulation loop is critical for cancer associated fibroblasts-enhanced tumor growth of oral squamous cell carcinoma
    • doi: 10.1093/carcin/bgu046
    • Li, X.; Xu, Q.; Wu, Y.; Li, J.; Tang, D.; Han, L.; Fan, Q. A CCL2/ROS autoregulation loop is critical for cancer associated fibroblasts-enhanced tumor growth of oral squamous cell carcinoma. Carcinogenesis 2014, doi: 10.1093/carcin/bgu046.
    • (2014) Carcinogenesis
    • Li, X.1    Xu, Q.2    Wu, Y.3    Li, J.4    Tang, D.5    Han, L.6    Fan, Q.7
  • 102
    • 84885648162 scopus 로고    scopus 로고
    • Hypoxia preconditioning of mesenchymal stromal cells enhances PC3 cell lymphatic metastasis accompanied by VEGFR-3/CCR7 activation
    • Huang, X.; Su, K.; Zhou, L.; Shen, G.; Dong, Q.; Lou, Y.; Zheng, S. Hypoxia preconditioning of mesenchymal stromal cells enhances PC3 cell lymphatic metastasis accompanied by VEGFR-3/CCR7 activation. J. Cell. Biochem. 2013, 114, 2834-2841.
    • (2013) J. Cell. Biochem , vol.114 , pp. 2834-2841
    • Huang, X.1    Su, K.2    Zhou, L.3    Shen, G.4    Dong, Q.5    Lou, Y.6    Zheng, S.7
  • 103
    • 84897556892 scopus 로고    scopus 로고
    • TGF-beta in CAF-mediated tumor growth and metastasis
    • doi:10.1016/j.semcancer.2013.12.008
    • Calon, A.; Tauriello, D.V.; Batlle, E. TGF-beta in CAF-mediated tumor growth and metastasis. Semin. Cancer Biol. 2014, doi:10.1016/j.semcancer.2013.12.008.
    • (2014) Semin. Cancer Biol
    • Calon, A.1    Tauriello, D.V.2    Batlle, E.3
  • 104
    • 77949347731 scopus 로고    scopus 로고
    • Pathogenesis of osteoblastic bone metastases from prostate cancer
    • Ibrahim, T.; Flamini, E.; Mercatali, L.; Sacanna, E.; Serra, P.; Amadori, D. Pathogenesis of osteoblastic bone metastases from prostate cancer. Cancer 2010, 116, 1406-1418.
    • (2010) Cancer , vol.116 , pp. 1406-1418
    • Ibrahim, T.1    Flamini, E.2    Mercatali, L.3    Sacanna, E.4    Serra, P.5    Amadori, D.6
  • 105
    • 30944436527 scopus 로고    scopus 로고
    • Mechanisms of disease: Roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis
    • Blair, J.M.; Zhou, H.; Seibel, M.J.; Dunstan, C.R. Mechanisms of disease: Roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis. Nat. Clin. Pract. Oncol. 2006, 3, 41-49.
    • (2006) Nat. Clin. Pract. Oncol , vol.3 , pp. 41-49
    • Blair, J.M.1    Zhou, H.2    Seibel, M.J.3    Dunstan, C.R.4
  • 106
    • 51049121618 scopus 로고    scopus 로고
    • RANK ligand inhibition plus docetaxel improves survival and reduces tumor burden in a murine model of prostate cancer bone metastasis
    • Miller, R.E.; Roudier, M.; Jones, J.; Armstrong, A.; Canon, J.; Dougall, W.C. RANK ligand inhibition plus docetaxel improves survival and reduces tumor burden in a murine model of prostate cancer bone metastasis. Mol. Cancer Ther. 2008, 7, 2160-2169.
    • (2008) Mol. Cancer Ther , vol.7 , pp. 2160-2169
    • Miller, R.E.1    Roudier, M.2    Jones, J.3    Armstrong, A.4    Canon, J.5    Dougall, W.C.6
  • 107
    • 37449004858 scopus 로고    scopus 로고
    • RANKL acts directly on RANK-expressing prostate tumor cells and mediates migration and expression of tumor metastasis genes
    • Armstrong, A.P.; Miller, R.E.; Jones, J.C.; Zhang, J.; Keller, E.T.; Dougall, W.C. RANKL acts directly on RANK-expressing prostate tumor cells and mediates migration and expression of tumor metastasis genes. Prostate 2008, 68, 92-104.
    • (2008) Prostate , vol.68 , pp. 92-104
    • Armstrong, A.P.1    Miller, R.E.2    Jones, J.C.3    Zhang, J.4    Keller, E.T.5    Dougall, W.C.6
  • 108
    • 59149087622 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor-kappa B ligand (RANKL) stimulates bone-associated tumors through functional RANK expressed on bone-associated cancer cells?
    • Mori, K.; Ando, K.; Heymann, D.; Redini, F. Receptor activator of nuclear factor-kappa B ligand (RANKL) stimulates bone-associated tumors through functional RANK expressed on bone-associated cancer cells? Histol. Histopathol. 2009, 24, 235-242.
    • (2009) Histol. Histopathol , vol.24 , pp. 235-242
    • Mori, K.1    Ando, K.2    Heymann, D.3    Redini, F.4
  • 109
    • 33847729474 scopus 로고    scopus 로고
    • DU145 human prostate cancer cells express functional receptor activator of NFkappaB: New insights in the prostate cancer bone metastasis process
    • Mori, K.; Le Goff, B.; Charrier, C.; Battaglia, S.; Heymann, D.; Redini, F. DU145 human prostate cancer cells express functional receptor activator of NFkappaB: New insights in the prostate cancer bone metastasis process. Bone 2007, 40, 981-990.
    • (2007) Bone , vol.40 , pp. 981-990
    • Mori, K.1    Le Goff, B.2    Charrier, C.3    Battaglia, S.4    Heymann, D.5    Redini, F.6
  • 110
    • 74249112769 scopus 로고    scopus 로고
    • Osteolytic prostate cancer cells induce the expression of specific cytokines in bone-forming osteoblasts through a Stat3/5-dependent mechanism
    • Schulze, J.; Albers, J.; Baranowsky, A.; Keller, J.; Spiro, A.; Streichert, T.; Zustin, J.; Amling, M.; Schinke, T. Osteolytic prostate cancer cells induce the expression of specific cytokines in bone-forming osteoblasts through a Stat3/5-dependent mechanism. Bone 2010, 46, 524-533.
    • (2010) Bone , vol.46 , pp. 524-533
    • Schulze, J.1    Albers, J.2    Baranowsky, A.3    Keller, J.4    Spiro, A.5    Streichert, T.6    Zustin, J.7    Amling, M.8    Schinke, T.9
  • 111
    • 48649094682 scopus 로고    scopus 로고
    • Histopathological assessment of prostate cancer bone osteoblastic metastases
    • Roudier, M.P.; Morrissey, C.; True, L.D.; Higano, C.S.; Vessella, R.L.; Ott, S.M. Histopathological assessment of prostate cancer bone osteoblastic metastases. J. Urol. 2008, 180, 1154-1160.
    • (2008) J. Urol , vol.180 , pp. 1154-1160
    • Roudier, M.P.1    Morrissey, C.2    True, L.D.3    Higano, C.S.4    Vessella, R.L.5    Ott, S.M.6
  • 113
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D.; Weinberg, R.A. Hallmarks of cancer: The next generation. Cell 2011, 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 114
    • 84891824280 scopus 로고    scopus 로고
    • STAT3 activation: A key factor in tumor immunoescape
    • Rebe, C.; Vegran, F.; Berger, H.; Ghiringhelli, F. STAT3 activation: A key factor in tumor immunoescape. JAKSTAT 2013, 2, e23010.
    • (2013) JAKSTAT , vol.2
    • Rebe, C.1    Vegran, F.2    Berger, H.3    Ghiringhelli, F.4
  • 115
    • 84874669956 scopus 로고    scopus 로고
    • HVEM: An unusual TNF receptor family member important for mucosal innate immune responses to microbes
    • Shui, J.W.; Kronenberg, M. HVEM: An unusual TNF receptor family member important for mucosal innate immune responses to microbes. Gut Microbes 2013, 4, 146-151.
    • (2013) Gut Microbes , vol.4 , pp. 146-151
    • Shui, J.W.1    Kronenberg, M.2
  • 116
    • 84862111685 scopus 로고    scopus 로고
    • IL-27 production and STAT3-dependent upregulation of B7-H1 mediate immune regulatory functions of liver plasmacytoid dendritic cells
    • Matta, B.M.; Raimondi, G.; Rosborough, B.R.; Sumpter, T.L.; Thomson, A.W. IL-27 production and STAT3-dependent upregulation of B7-H1 mediate immune regulatory functions of liver plasmacytoid dendritic cells. J. Immunol. 2012, 188, 5227-5237.
    • (2012) J. Immunol , vol.188 , pp. 5227-5237
    • Matta, B.M.1    Raimondi, G.2    Rosborough, B.R.3    Sumpter, T.L.4    Thomson, A.W.5
  • 118
    • 84873336707 scopus 로고    scopus 로고
    • The activation of MAPK in melanoma cells resistant to BRAF inhibition promotes PD-L1 expression that is reversible by MEK and PI3K inhibition
    • Jiang, X.; Zhou, J.; Giobbie-Hurder, A.; Wargo, J.; Hodi, F.S. The activation of MAPK in melanoma cells resistant to BRAF inhibition promotes PD-L1 expression that is reversible by MEK and PI3K inhibition. Clin. Cancer Res. 2013, 19, 598-609.
    • (2013) Clin. Cancer Res , vol.19 , pp. 598-609
    • Jiang, X.1    Zhou, J.2    Giobbie-Hurder, A.3    Wargo, J.4    Hodi, F.S.5
  • 119
    • 84856403025 scopus 로고    scopus 로고
    • Class I histone deacetylase inhibitor entinostat suppresses regulatory T cells and enhances immunotherapies in renal and prostate cancer models
    • Shen, L.; Ciesielski, M.; Ramakrishnan, S.; Miles, K.M.; Ellis, L.; Sotomayor, P.; Shrikant, P.; Fenstermaker, R.; Pili, R. Class I histone deacetylase inhibitor entinostat suppresses regulatory T cells and enhances immunotherapies in renal and prostate cancer models. PLoS One 2012, 7, e30815.
    • (2012) PLoS One , vol.7
    • Shen, L.1    Ciesielski, M.2    Ramakrishnan, S.3    Miles, K.M.4    Ellis, L.5    Sotomayor, P.6    Shrikant, P.7    Fenstermaker, R.8    Pili, R.9
  • 120
    • 84880697448 scopus 로고    scopus 로고
    • The role of IL-6 in the radiation response of prostate cancer
    • Wu, C.T.; Chen, M.F.; Chen, W.C.; Hsieh, C.C. The role of IL-6 in the radiation response of prostate cancer. Radiat. Oncol. 2013, 8, e159.
    • (2013) Radiat. Oncol , vol.8
    • Wu, C.T.1    Chen, M.F.2    Chen, W.C.3    Hsieh, C.C.4
  • 121
    • 84884752495 scopus 로고    scopus 로고
    • Infiltrating macrophages promote prostate tumorigenesis via modulating androgen receptor-mediated CCL4-STAT3 signaling
    • Fang, L.Y.; Izumi, K.; Lai, K.P.; Liang, L.; Li, L.; Miyamoto, H.; Lin, W.J.; Chang, C. Infiltrating macrophages promote prostate tumorigenesis via modulating androgen receptor-mediated CCL4-STAT3 signaling. Cancer Res. 2013, 73, 5633-5646.
    • (2013) Cancer Res , vol.73 , pp. 5633-5646
    • Fang, L.Y.1    Izumi, K.2    Lai, K.P.3    Liang, L.4    Li, L.5    Miyamoto, H.6    Lin, W.J.7    Chang, C.8
  • 122
    • 84882653809 scopus 로고    scopus 로고
    • Anti-androgen receptor ASC-J9 versus anti-androgens MDV3100 (Enzalutamide) or Casodex (Bicalutamide) leads to opposite effects on prostate cancer metastasis via differential modulation of macrophage infiltration and STAT3-CCL2 signaling
    • Lin, T.H.; Izumi, K.; Lee, S.O.; Lin, W.J.; Yeh, S.; Chang, C. Anti-androgen receptor ASC-J9 versus anti-androgens MDV3100 (Enzalutamide) or Casodex (Bicalutamide) leads to opposite effects on prostate cancer metastasis via differential modulation of macrophage infiltration and STAT3-CCL2 signaling. Cell. Death Dis. 2013, 4, e764.
    • (2013) Cell. Death Dis , vol.4
    • Lin, T.H.1    Izumi, K.2    Lee, S.O.3    Lin, W.J.4    Yeh, S.5    Chang, C.6
  • 123
    • 77949379050 scopus 로고    scopus 로고
    • B-cell-derived lymphotoxin promotes castration-resistant prostate cancer
    • Ammirante, M.; Luo, J.L.; Grivennikov, S.; Nedospasov, S.; Karin, M. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature 2010, 464, 302-305.
    • (2010) Nature , vol.464 , pp. 302-305
    • Ammirante, M.1    Luo, J.L.2    Grivennikov, S.3    Nedospasov, S.4    Karin, M.5
  • 124
    • 0035875931 scopus 로고    scopus 로고
    • Anti-interleukin-6 monoclonal antibody induces regression of human prostate cancer xenografts in nude mice
    • Smith, P.C.; Keller, E.T. Anti-interleukin-6 monoclonal antibody induces regression of human prostate cancer xenografts in nude mice. Prostate 2001, 48, 47-53.
    • (2001) Prostate , vol.48 , pp. 47-53
    • Smith, P.C.1    Keller, E.T.2
  • 125
    • 33645514605 scopus 로고    scopus 로고
    • Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice
    • Wallner, L.; Dai, J.; Escara-Wilke, J.; Zhang, J.; Yao, Z.; Lu, Y.; Trikha, M.; Nemeth, J.A.; Zaki, M.H.; Keller, E.T. Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice. Cancer Res. 2006, 66, 3087-3095.
    • (2006) Cancer Res , vol.66 , pp. 3087-3095
    • Wallner, L.1    Dai, J.2    Escara-Wilke, J.3    Zhang, J.4    Yao, Z.5    Lu, Y.6    Trikha, M.7    Nemeth, J.A.8    Zaki, M.H.9    Keller, E.T.10
  • 126
    • 84879099298 scopus 로고    scopus 로고
    • A phase 1 study of a chimeric monoclonal antibody against interleukin-6, siltuximab, combined with docetaxel in patients with metastatic castration-resistant prostate cancer
    • Hudes, G.; Tagawa, S.T.; Whang, Y.E.; Qi, M.; Qin, X.; Puchalski, T.A.; Reddy, M.; Cornfeld, M.; Eisenberger, M. A phase 1 study of a chimeric monoclonal antibody against interleukin-6, siltuximab, combined with docetaxel in patients with metastatic castration-resistant prostate cancer. Invest. New Drugs 2013, 31, 669-676.
    • (2013) Invest. New Drugs , vol.31 , pp. 669-676
    • Hudes, G.1    Tagawa, S.T.2    Whang, Y.E.3    Qi, M.4    Qin, X.5    Puchalski, T.A.6    Reddy, M.7    Cornfeld, M.8    Eisenberger, M.9
  • 127
    • 83255176682 scopus 로고    scopus 로고
    • Randomised phase II study of siltuximab (CNTO 328), an anti-IL-6 monoclonal antibody, in combination with mitoxantrone/prednisone versus mitoxantrone/prednisone alone in metastatic castration-resistant prostate cancer
    • Fizazi, K.; de Bono, J.S.; Flechon, A.; Heidenreich, A.; Voog, E.; Davis, N.B.; Qi, M.; Bandekar, R.; Vermeulen, J.T.; Cornfeld, M. et al. Randomised phase II study of siltuximab (CNTO 328), an anti-IL-6 monoclonal antibody, in combination with mitoxantrone/prednisone versus mitoxantrone/prednisone alone in metastatic castration-resistant prostate cancer. Eur. J. Cancer 2012, 48, 85-93.
    • (2012) Eur. J. Cancer , vol.48 , pp. 85-93
    • Fizazi, K.1    de Bono, J.S.2    Flechon, A.3    Heidenreich, A.4    Voog, E.5    Davis, N.B.6    Qi, M.7    Bandekar, R.8    Vermeulen, J.T.9    Cornfeld, M.10
  • 128
    • 41949104346 scopus 로고    scopus 로고
    • Design and End Points of Clinical Trials For Patients With Progressive Prostate Cancer and Castrate Levels of Testosterone: Recommendations of the Prostate Cancer Clinical Trials Working Group
    • Scher, H.I.; Halabi, S.; Tannock, I.; Morris, M.; Sternberg, C.N.; Carducci, M.A.; Eisenberger, M.A.; Higano, C.G.; Bubley, J.; Dreicer, R. et al. Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: Recommendations of the Prostate Cancer Clinical Trials Working Group. J. Clin. Oncol. 2008, 26, 1148-1159.
    • (2008) J. Clin. Oncol , vol.26 , pp. 1148-1159
    • Scher, H.I.1    Halabi, S.2    Tannock, I.3    Morris, M.4    Sternberg, C.N.5    Carducci, M.A.6    Eisenberger, M.A.7    Higano, C.G.8    Bubley, J.9    Dreicer, R.10
  • 129
    • 84876420606 scopus 로고    scopus 로고
    • The promise of heat shock protein inhibitors in the treatment of castration resistant prostate cancer
    • Ischia, J.; Saad, F.; Gleave, M. The promise of heat shock protein inhibitors in the treatment of castration resistant prostate cancer. Curr. Opin. Urol. 2013, 23, 194-200.
    • (2013) Curr. Opin. Urol , vol.23 , pp. 194-200
    • Ischia, J.1    Saad, F.2    Gleave, M.3
  • 130
    • 28244456529 scopus 로고    scopus 로고
    • Increased Hsp27 after androgen ablation facilitates androgen-independent progression in prostate cancer via signal transducers and activators of transcription 3-mediated suppression of apoptosis
    • Rocchi, P.; Beraldi, E.; Ettinger, S.; Fazli, L.; Vessella, R.L.; Nelson, C.; Gleave, M. Increased Hsp27 after androgen ablation facilitates androgen-independent progression in prostate cancer via signal transducers and activators of transcription 3-mediated suppression of apoptosis. Cancer Res. 2005, 65, 11083-11093.
    • (2005) Cancer Res , vol.65 , pp. 11083-11093
    • Rocchi, P.1    Beraldi, E.2    Ettinger, S.3    Fazli, L.4    Vessella, R.L.5    Nelson, C.6    Gleave, M.7
  • 131
  • 132
    • 84880487998 scopus 로고    scopus 로고
    • Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha, c-Jun and androgen receptor
    • Guo, H.; Xu, Y.M.; Ye, Z.Q.; Yu, J.H.; Hu, X.Y. Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha, c-Jun and androgen receptor. Pharmazie 2013, 68, 431-434.
    • (2013) Pharmazie , vol.68 , pp. 431-434
    • Guo, H.1    Xu, Y.M.2    Ye, Z.Q.3    Yu, J.H.4    Hu, X.Y.5
  • 133
    • 84861476075 scopus 로고    scopus 로고
    • Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathway
    • Yang, C.L.; Liu, Y.Y.; Ma, Y.G.; Xue, Y.X.; Liu, D.G.; Ren, Y.; Liu, X.B.; Li, Y.; Li, Z. Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathway. PLoS One 2012, 7, e37960.
    • (2012) PLoS One , vol.7
    • Yang, C.L.1    Liu, Y.Y.2    Ma, Y.G.3    Xue, Y.X.4    Liu, D.G.5    Ren, Y.6    Liu, X.B.7    Li, Y.8    Li, Z.9
  • 134
    • 28044460494 scopus 로고    scopus 로고
    • Caspase-dependent apoptosis induction by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, in PC-3 human prostate cancer cells is mediated by Bax and Bak
    • Singh, S.V.; Zeng, Y.; Xiao, D.; Vogel, V.G.; Nelson, J.B.; Dhir, R.; Tripathi, Y.B. Caspase-dependent apoptosis induction by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, in PC-3 human prostate cancer cells is mediated by Bax and Bak. Mol. Cancer Ther. 2005, 4, 1747-1754.
    • (2005) Mol. Cancer Ther , vol.4 , pp. 1747-1754
    • Singh, S.V.1    Zeng, Y.2    Xiao, D.3    Vogel, V.G.4    Nelson, J.B.5    Dhir, R.6    Tripathi, Y.B.7
  • 137
    • 78149460936 scopus 로고    scopus 로고
    • Effect of capsaicin on prostate cancer cells
    • Diaz-Laviada, I. Effect of capsaicin on prostate cancer cells. Future Oncol. 2010, 6, 1545-1550.
    • (2010) Future Oncol , vol.6 , pp. 1545-1550
    • Diaz-Laviada, I.1
  • 138
    • 63349085786 scopus 로고    scopus 로고
    • Capsaicin inhibits the IL-6/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress
    • Lee, H.K.; Seo, I.A.; Shin, Y.K.; Park, J.W.; Suh, D.J.; Park, H.T. Capsaicin inhibits the IL-6/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress. Biochem. Biophys. Res. Commun. 2009, 382, 445-450.
    • (2009) Biochem. Biophys. Res. Commun , vol.382 , pp. 445-450
    • Lee, H.K.1    Seo, I.A.2    Shin, Y.K.3    Park, J.W.4    Suh, D.J.5    Park, H.T.6
  • 139
    • 84874610297 scopus 로고    scopus 로고
    • Celastrol suppresses tumor cell growth through targeting an AR-ERG-NF-κB pathway in TMPRSS2/ERG fusion gene expressing prostate cancer
    • Shao, L.; Zhou, Z.; Cai, Y.; Castro, P.; Dakhov, O.; Shi, P.; Bai, Y.; Ji, H.; Shen, W.; Wang, J. Celastrol suppresses tumor cell growth through targeting an AR-ERG-NF-κB pathway in TMPRSS2/ERG fusion gene expressing prostate cancer. PLoS One 2013, 8, e58391.
    • (2013) PLoS One , vol.8
    • Shao, L.1    Zhou, Z.2    Cai, Y.3    Castro, P.4    Dakhov, O.5    Shi, P.6    Bai, Y.7    Ji, H.8    Shen, W.9    Wang, J.10
  • 140
    • 84864835881 scopus 로고    scopus 로고
    • Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo
    • Rajendran, P.; Li, F.; Shanmugam, M.K.; Kannaiyan, R.; Goh, J.N.; Wong, K.F.; Wang, W.; Khin, E.; Tergaonkar, V.; Kumar, A.P. et al. Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo. Cancer Prev. Res. 2012, 5, 631-643.
    • (2012) Cancer Prev. Res , vol.5 , pp. 631-643
    • Rajendran, P.1    Li, F.2    Shanmugam, M.K.3    Kannaiyan, R.4    Goh, J.N.5    Wong, K.F.6    Wang, W.7    Khin, E.8    Tergaonkar, V.9    Kumar, A.P.10
  • 142
    • 84878530487 scopus 로고    scopus 로고
    • The anticancer mechanism of caffeic acid phenethyl ester (CAPE): Review of melanomas, lung and prostate cancers
    • Ozturk, G.; Ginis, Z.; Akyol, S.; Erden, G.; Gurel, A.; Akyol, O. The anticancer mechanism of caffeic acid phenethyl ester (CAPE): Review of melanomas, lung and prostate cancers. Eur. Rev. Med. Pharmacol. Sci. 2012, 16, 2064-2068.
    • (2012) Eur. Rev. Med. Pharmacol. Sci , vol.16 , pp. 2064-2068
    • Ozturk, G.1    Ginis, Z.2    Akyol, S.3    Erden, G.4    Gurel, A.5    Akyol, O.6
  • 143
    • 84861553261 scopus 로고    scopus 로고
    • Protective effect of caffeic acid on paclitaxel induced anti-proliferation and apoptosis of lung cancer cells involves NF-κB pathway
    • Lin, C.L.; Chen, R.F.; Chen, J.Y.; Chu, Y.C.; Wang, H.M.; Chou, H.L.; Chang, W.C.; Fong, Y.; Chang, W.T.; Wu, C.Y. et al. Protective effect of caffeic acid on paclitaxel induced anti-proliferation and apoptosis of lung cancer cells involves NF-κB pathway. Int. J. Mol. Sci. 2012, 13, 6236-6245.
    • (2012) Int. J. Mol. Sci , vol.13 , pp. 6236-6245
    • Lin, C.L.1    Chen, R.F.2    Chen, J.Y.3    Chu, Y.C.4    Wang, H.M.5    Chou, H.L.6    Chang, W.C.7    Fong, Y.8    Chang, W.T.9    Wu, C.Y.10
  • 144
    • 0030598398 scopus 로고    scopus 로고
    • Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells
    • Duncan, K.L.; Duncan, M.D.; Alley, M.C.; Sausville, E.A. Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells. Biochem. Pharmacol. 1996, 52, 1553-1560.
    • (1996) Biochem. Pharmacol , vol.52 , pp. 1553-1560
    • Duncan, K.L.1    Duncan, M.D.2    Alley, M.C.3    Sausville, E.A.4
  • 145
    • 77953807862 scopus 로고    scopus 로고
    • Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin
    • Liu, T.; Peng, H.; Zhang, M.; Deng, Y.; Wu, Z. Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin. Eur. J. Pharmacol. 2010, 641, 15-22.
    • (2010) Eur. J. Pharmacol , vol.641 , pp. 15-22
    • Liu, T.1    Peng, H.2    Zhang, M.3    Deng, Y.4    Wu, Z.5
  • 146
    • 84855350566 scopus 로고    scopus 로고
    • Cryptotanshinone suppresses androgen receptor-mediated growth in androgen dependent and castration resistant prostate cancer cells
    • Xu, D.; Lin, T.H.; Li, S.; Da, J.; Wen, X.Q.; Ding, J.; Chang, C.; Yeh, S. Cryptotanshinone suppresses androgen receptor-mediated growth in androgen dependent and castration resistant prostate cancer cells. Cancer Lett. 2012, 316, 11-22.
    • (2012) Cancer Lett , vol.316 , pp. 11-22
    • Xu, D.1    Lin, T.H.2    Li, S.3    Da, J.4    Wen, X.Q.5    Ding, J.6    Chang, C.7    Yeh, S.8
  • 147
    • 58249119435 scopus 로고    scopus 로고
    • Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells
    • Shin, D.S.; Kim, H.N.; Shin, K.D.; Yoon, Y.J.; Kim, S.J.; Han, D.C.; Kwon, B.M. Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res. 2009, 69, 193-202.
    • (2009) Cancer Res , vol.69 , pp. 193-202
    • Shin, D.S.1    Kim, H.N.2    Shin, K.D.3    Yoon, Y.J.4    Kim, S.J.5    Han, D.C.6    Kwon, B.M.7
  • 148
    • 77957372039 scopus 로고    scopus 로고
    • A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer
    • Heath, E.I.; Heilbrun, L.K.; Li, J.; Vaishampayan, U.; Harper, F.; Pemberton, P.; Sarkar, F.H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am. J. Transl. Res. 2010, 2, 402-411.
    • (2010) Am. J. Transl. Res , vol.2 , pp. 402-411
    • Heath, E.I.1    Heilbrun, L.K.2    Li, J.3    Vaishampayan, U.4    Harper, F.5    Pemberton, P.6    Sarkar, F.H.7
  • 149
    • 80051663254 scopus 로고    scopus 로고
    • Antiandrogenic and growth inhibitory effects of ring-substituted analogs of 3,3'-diindolylmethane (ring-DIMs) in hormone-responsive LNCaP human prostate cancer cells
    • Abdelbaqi, K.; Lack, N.; Guns, E.T.; Kotha, L.; Safe, S.; Sanderson, J.T. Antiandrogenic and growth inhibitory effects of ring-substituted analogs of 3,3'-diindolylmethane (ring-DIMs) in hormone-responsive LNCaP human prostate cancer cells. Prostate 2011, 71, 1401-1412.
    • (2011) Prostate , vol.71 , pp. 1401-1412
    • Abdelbaqi, K.1    Lack, N.2    Guns, E.T.3    Kotha, L.4    Safe, S.5    Sanderson, J.T.6
  • 150
    • 80052576657 scopus 로고    scopus 로고
    • Inactivation of AR/TMPRSS2-ERG/Wnt signaling networks attenuates the aggressive behavior of prostate cancer cells
    • Li, Y.; Kong, D.; Wang, Z.; Ahmad, A.; Bao, B.; Padhye, S.; Sarkar, F.H. Inactivation of AR/TMPRSS2-ERG/Wnt signaling networks attenuates the aggressive behavior of prostate cancer cells. Cancer Prev. Res. 2011, 4, 1495-1506.
    • (2011) Cancer Prev. Res , vol.4 , pp. 1495-1506
    • Li, Y.1    Kong, D.2    Wang, Z.3    Ahmad, A.4    Bao, B.5    Padhye, S.6    Sarkar, F.H.7
  • 151
    • 84898848365 scopus 로고    scopus 로고
    • Ring-substituted analogs of 3,3'-diindolylmethane (DIM) induce apoptosis and necrosis in androgen-dependent and -independent prostate cancer cells
    • Goldberg, A.A.; Titorenko, V.I.; Beach, A.; Abdelbaqi, K.; Safe, S.; Sanderson, J.T. Ring-substituted analogs of 3,3'-diindolylmethane (DIM) induce apoptosis and necrosis in androgen-dependent and -independent prostate cancer cells. Invest. New Drugs 2014, 32, 25-36.
    • (2014) Invest. New Drugs , vol.32 , pp. 25-36
    • Goldberg, A.A.1    Titorenko, V.I.2    Beach, A.3    Abdelbaqi, K.4    Safe, S.5    Sanderson, J.T.6
  • 152
    • 84898889926 scopus 로고    scopus 로고
    • Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells
    • Wong, C.P.; Hsu, A.; Buchanan, A.; Palomera-Sanchez, Z.; Beaver, L.M.; Houseman, E.A.; Williams, D.E.; Dashwood, R.H.; Ho, E. Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells. PLoS One 2014, 9, e86787.
    • (2014) PLoS One , vol.9
    • Wong, C.P.1    Hsu, A.2    Buchanan, A.3    Palomera-Sanchez, Z.4    Beaver, L.M.5    Houseman, E.A.6    Williams, D.E.7    Dashwood, R.H.8    Ho, E.9
  • 153
    • 85008726865 scopus 로고    scopus 로고
    • Regulation of Janus-activated kinase-2 (JAK2) by diindolylmethane in ovarian cancer in vitro and in vivo
    • Kandala, P.K.; Srivastava, S.K. Regulation of Janus-activated kinase-2 (JAK2) by diindolylmethane in ovarian cancer in vitro and in vivo. Drug Discov. Ther. 2012, 6, 94-101.
    • (2012) Drug Discov. Ther , vol.6 , pp. 94-101
    • Kandala, P.K.1    Srivastava, S.K.2
  • 155
    • 16844386205 scopus 로고    scopus 로고
    • Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth
    • Cha, T.L.; Qiu, L.; Chen, C.T.; Wen, Y.; Hung, M.C. Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth. Cancer Res. 2005, 65, 2287-2295.
    • (2005) Cancer Res , vol.65 , pp. 2287-2295
    • Cha, T.L.1    Qiu, L.2    Chen, C.T.3    Wen, Y.4    Hung, M.C.5
  • 157
    • 84860187078 scopus 로고    scopus 로고
    • Castration-resistant prostate cancer: Systemic therapy in 2012
    • Maluf, F.C.; Smaletz, O.; Herchenhorn, D. Castration-resistant prostate cancer: Systemic therapy in 2012. Clinics 2012, 67, 389-394.
    • (2012) Clinics , vol.67 , pp. 389-394
    • Maluf, F.C.1    Smaletz, O.2    Herchenhorn, D.3
  • 158
    • 77958126831 scopus 로고    scopus 로고
    • Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling
    • Walker, S.R.; Chaudhury, M.; Nelson, E.A.; Frank, D.A. Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling. Mol. Pharmacol. 2010, 78, 903-908.
    • (2010) Mol. Pharmacol , vol.78 , pp. 903-908
    • Walker, S.R.1    Chaudhury, M.2    Nelson, E.A.3    Frank, D.A.4
  • 159
    • 2942554803 scopus 로고    scopus 로고
    • Inhibitory effects of evodiamine on the growth of human prostate cancer cell line LNCaP
    • Kan, S.F.; Huang, W.J.; Lin, L.C.; Wang, P.S. Inhibitory effects of evodiamine on the growth of human prostate cancer cell line LNCaP. Int. J. Cancer 2004, 110, 641-651.
    • (2004) Int. J. Cancer , vol.110 , pp. 641-651
    • Kan, S.F.1    Huang, W.J.2    Lin, L.C.3    Wang, P.S.4
  • 160
    • 10344234253 scopus 로고    scopus 로고
    • Induction of mitotic arrest and apoptosis in human prostate cancer PC-3 cells by evodiamine
    • Huang, D.M.; Cai, X.; Lu, W.; Hu, C.; Xu, X.; Yu, Q.; Cao, P. Induction of mitotic arrest and apoptosis in human prostate cancer PC-3 cells by evodiamine. J. Urol. 2005, 173, 256-261.
    • (2005) J. Urol , vol.173 , pp. 256-261
    • Huang, D.M.1    Cai, X.2    Lu, W.3    Hu, C.4    Xu, X.5    Yu, Q.6    Cao, P.7
  • 161
    • 84870364791 scopus 로고    scopus 로고
    • Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells
    • Yang, J.; Renaud, M.; Sanderson, J.T. Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells. Cancer Lett. 2013, 328, 243-251.
    • (2013) Cancer Lett , vol.328 , pp. 243-251
    • Yang, J.1    Renaud, M.2    Sanderson, J.T.3
  • 163
    • 79551516170 scopus 로고    scopus 로고
    • Proliferative and androgenic effects of indirubin derivatives in LNCaP human prostate cancer cells at sub-apoptotic concentrations
    • Rivest, P.; Renaud, M.; Sanderson, J.T. Proliferative and androgenic effects of indirubin derivatives in LNCaP human prostate cancer cells at sub-apoptotic concentrations. Chem. Biol. Interact. 2011, 189, 177-185.
    • (2011) Chem. Biol. Interact , vol.189 , pp. 177-185
    • Rivest, P.1    Renaud, M.2    Sanderson, J.T.3
  • 164
    • 84875458307 scopus 로고    scopus 로고
    • A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation
    • Zhang, X.; Sun, Y.; Pireddu, R.; Yang, H.; Urlam, M.K.; Lawrence, H.R.; Guida, W.C.; Lawrence, N.J.; Sebti, S.M. A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation. Cancer Res. 2013, 73, 1922-1933.
    • (2013) Cancer Res , vol.73 , pp. 1922-1933
    • Zhang, X.1    Sun, Y.2    Pireddu, R.3    Yang, H.4    Urlam, M.K.5    Lawrence, H.R.6    Guida, W.C.7    Lawrence, N.J.8    Sebti, S.M.9
  • 165
    • 33750982120 scopus 로고    scopus 로고
    • Stattic: A small-molecule inhibitor of STAT3 activation and dimerization
    • Schust, J.; Sperl, B.; Hollis, A.; Mayer, T.U.; Berg, T. Stattic: A small-molecule inhibitor of STAT3 activation and dimerization. Chem. Biol. 2006, 13, 1235-1242.
    • (2006) Chem. Biol , vol.13 , pp. 1235-1242
    • Schust, J.1    Sperl, B.2    Hollis, A.3    Mayer, T.U.4    Berg, T.5
  • 167
    • 16344380754 scopus 로고    scopus 로고
    • A low-molecular-weight compound discovered through virtual database screening inhibits STAT3 function in breast cancer cells
    • Song, H.; Wang, R.; Wang, S.; Lin, J. A low-molecular-weight compound discovered through virtual database screening inhibits STAT3 function in breast cancer cells. Proc. Natl. Acad. Sci. USA 2005, 102, 4700-4705.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 4700-4705
    • Song, H.1    Wang, R.2    Wang, S.3    Lin, J.4
  • 170
    • 73949111590 scopus 로고    scopus 로고
    • A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells
    • Lin, L.; Hutzen, B.; Li, P.K.; Ball, S.; Zuo, M.; DeAngelis, S.; Foust, E.; Sobo, M.; Friedman, L.; Bhasin, D. et al. A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells. Neoplasia 2010, 12, 39-50.
    • (2010) Neoplasia , vol.12 , pp. 39-50
    • Lin, L.1    Hutzen, B.2    Li, P.K.3    Ball, S.4    Zuo, M.5    Deangelis, S.6    Foust, E.7    Sobo, M.8    Friedman, L.9    Bhasin, D.10
  • 171
    • 84898892592 scopus 로고    scopus 로고
    • The effect of selective JAK2 inhibitor SAR302503 on tumorigenic STAT3 signaling in human prostate cancer in vivo
    • San Fransisco, CA, USA, 30 January-1 February
    • Moreira, D. The effect of selective JAK2 inhibitor SAR302503 on tumorigenic STAT3 signaling in human prostate cancer in vivo. In Proceedings of the 2014 Genitourinary Cancers Symposium, San Fransisco, CA, USA, 30 January-1 February 2014.
    • (2014) Proceedings of the 2014 Genitourinary Cancers Symposium
    • Moreira, D.1
  • 172
    • 84895472517 scopus 로고    scopus 로고
    • Overcoming AC220 resistance of FLT3-ITD by SAR302503
    • Kesarwani, M.; Huber, E.; Azam, M. Overcoming AC220 resistance of FLT3-ITD by SAR302503. Blood Cancer J. 2013, 3, e138.
    • (2013) Blood Cancer J , vol.3
    • Kesarwani, M.1    Huber, E.2    Azam, M.3
  • 179
  • 182
    • 83555174315 scopus 로고    scopus 로고
    • The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells
    • Monaghan, K.A.; Khong, T.; Burns, C.J.; Spencer, A. The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells. Leukemia 2011, 25, 1891-1899.
    • (2011) Leukemia , vol.25 , pp. 1891-1899
    • Monaghan, K.A.1    Khong, T.2    Burns, C.J.3    Spencer, A.4
  • 184
    • 84862165045 scopus 로고    scopus 로고
    • New developments in castrate-resistant prostate cancer
    • Shore, N.; Mason, M.; de Reijke, T.M. New developments in castrate-resistant prostate cancer. BJU Int. 2012, 109, 22-32.
    • (2012) BJU Int , vol.109 , pp. 22-32
    • Shore, N.1    Mason, M.2    de Reijke, T.M.3
  • 185
    • 77950833182 scopus 로고    scopus 로고
    • Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3
    • Yang, F.; Brown, C.; Buettner, R.; Hedvat, M.; Starr, R.; Scuto, A.; Schroeder, A.; Jensen, M.; Jove, R. Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3. Mol. Cancer Ther. 2010, 9, 953-962.
    • (2010) Mol. Cancer Ther , vol.9 , pp. 953-962
    • Yang, F.1    Brown, C.2    Buettner, R.3    Hedvat, M.4    Starr, R.5    Scuto, A.6    Schroeder, A.7    Jensen, M.8    Jove, R.9
  • 187
    • 84886392415 scopus 로고    scopus 로고
    • Pharmacologic inhibition of JAK2-STAT5 signaling By JAK2 inhibitor AZD1480 potently suppresses growth of both primary and castrate-resistant prostate cancer
    • Gu, L.; Liao, Z.; Hoang, D.T.; Dagvadorj, A.; Gupta, S.; Blackmon, S.; Ellsworth, E.; Talati, P.; Leiby, B.; Zinda, M. et al. Pharmacologic inhibition of JAK2-STAT5 signaling By JAK2 inhibitor AZD1480 potently suppresses growth of both primary and castrate-resistant prostate cancer. Clin. Cancer Res. 2013, 19, 5658-5674.
    • (2013) Clin. Cancer Res , vol.19 , pp. 5658-5674
    • Gu, L.1    Liao, Z.2    Hoang, D.T.3    Dagvadorj, A.4    Gupta, S.5    Blackmon, S.6    Ellsworth, E.7    Talati, P.8    Leiby, B.9    Zinda, M.10
  • 188
    • 84874742657 scopus 로고    scopus 로고
    • Antiproliferative effect of gold(I) compound auranofin through inhibition of STAT3 and telomerase activity in MDA-MB 231 human breast cancer cells
    • Kim, N.H.; Park, H.J.; Oh, M.K.; Kim, I.S. Antiproliferative effect of gold(I) compound auranofin through inhibition of STAT3 and telomerase activity in MDA-MB 231 human breast cancer cells. BMB Rep. 2013, 46, 59-64.
    • (2013) BMB Rep , vol.46 , pp. 59-64
    • Kim, N.H.1    Park, H.J.2    Oh, M.K.3    Kim, I.S.4
  • 189
    • 35948995412 scopus 로고    scopus 로고
    • Auranofin blocks interleukin-6 signalling by inhibiting phosphorylation of JAK1 and STAT3
    • Kim, N.H.; Lee, M.Y.; Park, S.J.; Choi, J.S.; Oh, M.K.; Kim, I.S. Auranofin blocks interleukin-6 signalling by inhibiting phosphorylation of JAK1 and STAT3. Immunology 2007, 122, 607-614.
    • (2007) Immunology , vol.122 , pp. 607-614
    • Kim, N.H.1    Lee, M.Y.2    Park, S.J.3    Choi, J.S.4    Oh, M.K.5    Kim, I.S.6
  • 190
    • 4243156987 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines
    • Barton, B.E.; Karras, J.G.; Murphy, T.F.; Barton, A.; Huang, H.F. Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines. Mol. Cancer Ther. 2004, 3, 11-20.
    • (2004) Mol. Cancer Ther , vol.3 , pp. 11-20
    • Barton, B.E.1    Karras, J.G.2    Murphy, T.F.3    Barton, A.4    Huang, H.F.5
  • 191
    • 0030978808 scopus 로고    scopus 로고
    • Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: Tyrphostin AG490 inhibits STAT3 activation and growth of mycosis fungoides tumor cell lines
    • Nielsen, M.; Kaltoft, K.; Nordahl, M.; Ropke, C.; Geisler, C.; Mustelin, T.; Dobson, P.; Svejgaard, A.; Odum, N. Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: Tyrphostin AG490 inhibits STAT3 activation and growth of mycosis fungoides tumor cell lines. Proc. Natl. Acad. Sci. USA 1997, 94, 6764-6769.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 6764-6769
    • Nielsen, M.1    Kaltoft, K.2    Nordahl, M.3    Ropke, C.4    Geisler, C.5    Mustelin, T.6    Dobson, P.7    Svejgaard, A.8    Odum, N.9
  • 192
    • 84880692649 scopus 로고    scopus 로고
    • Interleukin-6-induced satellite cell proliferation is regulated by induction of the JAK2/STAT3 signalling pathway through cyclin D1 targeting
    • Kurosaka, M.; Machida, S. Interleukin-6-induced satellite cell proliferation is regulated by induction of the JAK2/STAT3 signalling pathway through cyclin D1 targeting. Cell Prolif. 2013, 46, 365-373.
    • (2013) Cell Prolif , vol.46 , pp. 365-373
    • Kurosaka, M.1    Machida, S.2
  • 193
    • 79959269602 scopus 로고    scopus 로고
    • Novel small molecule, XZH-5, inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells
    • Liu, A.; Liu, Y.; Xu, Z.; Yu, W.; Wang, H.; Li, C.; Lin, J. Novel small molecule, XZH-5, inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells. Cancer Sci. 2011, 102, 1381-1387.
    • (2011) Cancer Sci , vol.102 , pp. 1381-1387
    • Liu, A.1    Liu, Y.2    Xu, Z.3    Yu, W.4    Wang, H.5    Li, C.6    Lin, J.7
  • 194
    • 84867046550 scopus 로고    scopus 로고
    • XZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cells
    • Liu, A.; Liu, Y.; Jin, Z.; Hu, Q.; Lin, L.; Jou, D.; Yang, J.; Xu, Z.; Wang, H.; Li, C. et al. XZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cells. PLoS One 2012, 7, e46624.
    • (2012) PLoS One , vol.7
    • Liu, A.1    Liu, Y.2    Jin, Z.3    Hu, Q.4    Lin, L.5    Jou, D.6    Yang, J.7    Xu, Z.8    Wang, H.9    Li, C.10
  • 195
    • 77950190311 scopus 로고    scopus 로고
    • Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells
    • Lin, L.; Hutzen, B.; Zuo, M.; Ball, S.; Deangelis, S.; Foust, E.; Pandit, B.; Ihnat, M.A.; Shenoy, S.S.; Kulp, S. et al. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res. 2010, 70, 2445-2454.
    • (2010) Cancer Res , vol.70 , pp. 2445-2454
    • Lin, L.1    Hutzen, B.2    Zuo, M.3    Ball, S.4    Deangelis, S.5    Foust, E.6    Pandit, B.7    Ihnat, M.A.8    Shenoy, S.S.9    Kulp, S.10
  • 197
    • 85064289101 scopus 로고    scopus 로고
    • Dysregulation of JAK-STAT pathway in hematological malignancies and JAK inhibitors for clinical application
    • Furqan, M.; Mukhi, N.; Lee, B.; Liu, D. Dysregulation of JAK-STAT pathway in hematological malignancies and JAK inhibitors for clinical application. Biomark Res. 2013, 1, e5.
    • (2013) Biomark Res , vol.1
    • Furqan, M.1    Mukhi, N.2    Lee, B.3    Liu, D.4
  • 199
  • 200
    • 84862287729 scopus 로고    scopus 로고
    • A selective, orally bioavailable 1,2,4-triazolo[1,5-a]pyridine-based inhibitor of Janus kinase 2 for use in anticancer therapy: Discovery of CEP-33779
    • Dugan, B.J.; Gingrich, D.E.; Mesaros, E.F.; Milkiewicz, K.L.; Curry, M.A.; Zulli, A.L.; Dobrzanski, P.; Serdikoff, C.; Jan, M.; Angeles, T.S. et al. A selective, orally bioavailable 1,2,4-triazolo[1,5-a]pyridine-based inhibitor of Janus kinase 2 for use in anticancer therapy: Discovery of CEP-33779. J. Med. Chem. 2012, 55, 5243-5254.
    • (2012) J. Med. Chem , vol.55 , pp. 5243-5254
    • Dugan, B.J.1    Gingrich, D.E.2    Mesaros, E.F.3    Milkiewicz, K.L.4    Curry, M.A.5    Zulli, A.L.6    Dobrzanski, P.7    Serdikoff, C.8    Jan, M.9    Angeles, T.S.10
  • 201
    • 84868250804 scopus 로고    scopus 로고
    • Dynamic changes in the secondary structure of ECE-1 and XCE account for their different substrate specificities
    • doi:10.1186/1471-2105-13-285
    • Ul-Haq, Z.; Iqbal, S.; Moin, S.T. Dynamic changes in the secondary structure of ECE-1 and XCE account for their different substrate specificities. BMC Bioinforma. 2012, 13, doi:10.1186/1471-2105-13-285.
    • (2012) BMC Bioinforma , pp. 13
    • Ul-Haq, Z.1    Iqbal, S.2    Moin, S.T.3
  • 202
    • 79959528659 scopus 로고    scopus 로고
    • R723, a selective JAK2 inhibitor, effectively treats JAK2V617F-induced murine myeloproliferative neoplasm
    • Shide, K.; Kameda, T.; Markovtsov, V.; Shimoda, H.K.; Tonkin, E.; Fang, S.; Liu, C.; Gelman, M.; Lang, W.; Romero, J. et al. R723, a selective JAK2 inhibitor, effectively treats JAK2V617F-induced murine myeloproliferative neoplasm. Blood 2011, 117, 6866-6875.
    • (2011) Blood , vol.117 , pp. 6866-6875
    • Shide, K.1    Kameda, T.2    Markovtsov, V.3    Shimoda, H.K.4    Tonkin, E.5    Fang, S.6    Liu, C.7    Gelman, M.8    Lang, W.9    Romero, J.10
  • 203
    • 0032922590 scopus 로고    scopus 로고
    • Blocking signaling through the Gp130 receptor chain by interleukin-6 and oncostatin M inhibits PC-3 cell growth and sensitizes the tumor cells to etoposide and cisplatin-mediated cytotoxicity
    • Borsellino, N.; Bonavida, B.; Ciliberto, G.; Toniatti, C.; Travali, S.; D'Alessandro, N. Blocking signaling through the Gp130 receptor chain by interleukin-6 and oncostatin M inhibits PC-3 cell growth and sensitizes the tumor cells to etoposide and cisplatin-mediated cytotoxicity. Cancer 1999, 85, 134-144.
    • (1999) Cancer , vol.85 , pp. 134-144
    • Borsellino, N.1    Bonavida, B.2    Ciliberto, G.3    Toniatti, C.4    Travali, S.5    D'Alessandro, N.6
  • 204
    • 0036839144 scopus 로고    scopus 로고
    • In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp130/STAT3 pathway
    • Chatterjee, M.; Honemann, D.; Lentzsch, S.; Bommert, K.; Sers, C.; Herrmann, P.; Mathas, S.; Dorken, B.; Bargou, R.C. In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp130/STAT3 pathway. Blood 2002, 100, 3311-3318.
    • (2002) Blood , vol.100 , pp. 3311-3318
    • Chatterjee, M.1    Honemann, D.2    Lentzsch, S.3    Bommert, K.4    Sers, C.5    Herrmann, P.6    Mathas, S.7    Dorken, B.8    Bargou, R.C.9
  • 205
    • 84876117522 scopus 로고    scopus 로고
    • Humanised antihuman IL-6R antibody with interferon inhibits renal cell carcinoma cell growth in vitro and in vivo through suppressed SOCS3 expression
    • Oguro, T.; Ishibashi, K.; Sugino, T.; Hashimoto, K.; Tomita, S.; Takahashi, N.; Yanagida, T.; Haga, N.; Aikawa, K.; Suzutani, T. et al. Humanised antihuman IL-6R antibody with interferon inhibits renal cell carcinoma cell growth in vitro and in vivo through suppressed SOCS3 expression. Eur. J. Cancer 2013, 49, 1715-1724.
    • (2013) Eur. J. Cancer , vol.49 , pp. 1715-1724
    • Oguro, T.1    Ishibashi, K.2    Sugino, T.3    Hashimoto, K.4    Tomita, S.5    Takahashi, N.6    Yanagida, T.7    Haga, N.8    Aikawa, K.9    Suzutani, T.10
  • 206
    • 79955780881 scopus 로고    scopus 로고
    • JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling
    • Song, L.; Rawal, B.; Nemeth, J.A.; Haura, E.B. JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling. Mol. Cancer Ther. 2011, 10, 481-494.
    • (2011) Mol. Cancer Ther , vol.10 , pp. 481-494
    • Song, L.1    Rawal, B.2    Nemeth, J.A.3    Haura, E.B.4
  • 207
    • 84875266301 scopus 로고    scopus 로고
    • New strategies against prostate cancer-Pt(II)-based chemotherapy
    • Matos, C.S.; de Carvalho, A.L.; Lopes, R.P.; Marques, M.P. New strategies against prostate cancer-Pt(II)-based chemotherapy. Curr. Med. Chem. 2012, 19, 4678-4687.
    • (2012) Curr. Med. Chem , vol.19 , pp. 4678-4687
    • Matos, C.S.1    de Carvalho, A.L.2    Lopes, R.P.3    Marques, M.P.4
  • 208
    • 80052197203 scopus 로고    scopus 로고
    • Small molecule inhibitors of STAT3 for cancer therapy
    • Zhao, M.; Jiang, B.; Gao, F.H. Small molecule inhibitors of STAT3 for cancer therapy. Curr. Med. Chem. 2011, 18, 4012-4018.
    • (2011) Curr. Med. Chem , vol.18 , pp. 4012-4018
    • Zhao, M.1    Jiang, B.2    Gao, F.H.3
  • 209
    • 12344328541 scopus 로고    scopus 로고
    • Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity
    • Turkson, J.; Zhang, S.; Palmer, J.; Kay, H.; Stanko, J.; Mora, L.B.; Sebti, S.; Yu, H.; Jove, R. Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity. Mol. Cancer Ther. 2004, 3, 1533-1542.
    • (2004) Mol. Cancer Ther , vol.3 , pp. 1533-1542
    • Turkson, J.1    Zhang, S.2    Palmer, J.3    Kay, H.4    Stanko, J.5    Mora, L.B.6    Sebti, S.7    Yu, H.8    Jove, R.9
  • 210
    • 84858230349 scopus 로고    scopus 로고
    • A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line
    • Souissi, I.; Ladam, P.; Cognet, J.A.; Le Coquil, S.; Varin-Blank, N.; Baran-Marszak, F.; Metelev, V.; Fagard, R. A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line. Mol. Cancer 2012, 11, e12.
    • (2012) Mol. Cancer , vol.11
    • Souissi, I.1    Ladam, P.2    Cognet, J.A.3    Le Coquil, S.4    Varin-Blank, N.5    Baran-Marszak, F.6    Metelev, V.7    Fagard, R.8
  • 211
  • 212
    • 4644325545 scopus 로고    scopus 로고
    • G-quartet oligonucleotides: A new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis
    • Jing, N.; Thomas, S.M.; Kim, S.; Yeh, J.I.; Ferris, R.L.; Johnson, J.T.; Duvvuri, U.; Lee, J.; Sahu, N.; Joyce, S. G-quartet oligonucleotides: A new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis. Cancer Res. 2004, 64, 6603-6609.
    • (2004) Cancer Res , vol.64 , pp. 6603-6609
    • Jing, N.1    Thomas, S.M.2    Kim, S.3    Yeh, J.I.4    Ferris, R.L.5    Johnson, J.T.6    Duvvuri, U.7    Lee, J.8    Sahu, N.9    Joyce, S.10
  • 213
    • 0344984245 scopus 로고    scopus 로고
    • Targeting Stat3 With G-quartet Oligodeoxynucleotides In Human Cancer Cells
    • Jing, N.; Li, Y.; Xu, X.; Sha, W.; Li, P.; Feng, L.; Tweardy, D.J. Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells. DNA Cell. Biol. 2003, 22, 685-696.
    • (2003) DNA Cell. Biol , vol.22 , pp. 685-696
    • Jing, N.1    Li, Y.2    Xu, X.3    Sha, W.4    Li, P.5    Feng, L.6    Tweardy, D.J.7
  • 214
    • 79955673922 scopus 로고    scopus 로고
    • Plasmid-based Stat3 siRNA delivered by hydroxyapatite nanoparticles suppresses mouse prostate tumour growth in vivo
    • Liang, Z.W.; Guo, B.F.; Li, Y.; Li, X.J.; Li, X.; Zhao, L.J.; Gao, L.F.; Yu, H.; Zhao, X.J.; Zhang, L. et al. Plasmid-based Stat3 siRNA delivered by hydroxyapatite nanoparticles suppresses mouse prostate tumour growth in vivo. Asian J. Androl. 2011, 13, 481-486.
    • (2011) Asian J. Androl , vol.13 , pp. 481-486
    • Liang, Z.W.1    Guo, B.F.2    Li, Y.3    Li, X.J.4    Li, X.5    Zhao, L.J.6    Gao, L.F.7    Yu, H.8    Zhao, X.J.9    Zhang, L.10
  • 215
    • 3943103442 scopus 로고    scopus 로고
    • RNA interference targeting STAT3 inhibits growth and induces apoptosis of human prostate cancer cells
    • Lee, S.O.; Lou, W.; Qureshi, K.M.; Mehraein-Ghomi, F.; Trump, D.L.; Gao, A.C. RNA interference targeting STAT3 inhibits growth and induces apoptosis of human prostate cancer cells. Prostate 2004, 60, 303-309.
    • (2004) Prostate , vol.60 , pp. 303-309
    • Lee, S.O.1    Lou, W.2    Qureshi, K.M.3    Mehraein-Ghomi, F.4    Trump, D.L.5    Gao, A.C.6
  • 216
    • 3042748279 scopus 로고    scopus 로고
    • Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells
    • Konnikova, L.; Kotecki, M.; Kruger, M.M.; Cochran, B.H. Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells. BMC Cancer 2003, 3, e23.
    • (2003) BMC Cancer , vol.3
    • Konnikova, L.1    Kotecki, M.2    Kruger, M.M.3    Cochran, B.H.4
  • 219
    • 84859877124 scopus 로고    scopus 로고
    • Combining immunological and androgen-directed approaches: An emerging concept in prostate cancer immunotherapy
    • Antonarakis, E.S.; Drake, C.G. Combining immunological and androgen-directed approaches: An emerging concept in prostate cancer immunotherapy. Curr. Opin. Oncol. 2012, 24, 258-265.
    • (2012) Curr. Opin. Oncol , vol.24 , pp. 258-265
    • Antonarakis, E.S.1    Drake, C.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.